Angiogenesis in Cancer and Other Diseases: From Genes to Function to Therapy

joint with Biological Response to the Extracellular Matrix

Organizer(s): Rakesh K. Jain, Peter M. Carmeliet and James M. Pluda

Sponsored by Novartis Pharmaceuticals Corporation

Summary of Meeting:

Pathological angiogenesis is a hallmark of cancer and various ischemic and inflammatory diseases. Concerted efforts in this area of research are leading to the discovery of a growing number of pro- and anti-angiogenic molecules, some of which are already in clinical trials. The complex interactions among these molecules and their effect on vascular structure and function in different environments are beginning to be elucidated. This integrated understanding is leading to the development of a number of exciting and bold approaches to treat cancer and other diseases. However, there are several outstanding questions that must be addressed for successful translation of discoveries from the bench to the bedside. With advances in molecular genetics and the availability of molecular probes, imaging technologies, and therapeutic opportunities, we are now beginning to answer these questions. In this meeting, we discuss how normal and abnormal blood vessels form, how they function, what molecules (genes) are involved, how they are used for therapy, why caution is warranted and what key questions remain unanswered. We will first discuss tumor angiogenesis since it is most widely studied, and then, the emerging role of angiogenesis and vascular remodeling in non-neoplastic disorders resulting from ischemia, inflammation, obesity and vascular malformations.

Discounted Abstract Deadline: October 8 2001

Discounted Registration Deadline: December 7 2001

We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1 R13 CA94244-01

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