Web Desc
Mechanisms of Immunologic Tolerance and its Breakdown
Organizer(s): David W. Scott, Rachel R. Caspi, Anne Cooke and Terry L. Delovitch
Date: January 07 - 13, 2003
Location: Snowbird Resort, Snowbird, UT, USA
Sponsored in part by The Director's Sponsor Fund
For important information on the coronavirus, please click here
Summary of Meeting:
An understanding of the pathways of immunologic tolerance and the mechanisms of its breakdown in autoimmunity are critical to developing future therapies for a variety of autoimmune disorders, such as diabetes and multiple sclerosis. Novel approaches need to be developed for the treatment of the autoimmune disorders that lead to immune target cell destruction. This Keystone meeting is centered at understanding tolerance and its breakdown and bridging the gap between basic, pre-clinical and clinical studies (the co-chairs have devoted their entire careers to understanding immune tolerance and autoimmunity, including novel therapies). Thus, several speakers (and workshop chairs) will be strongly oriented towards basic studies, while others will focus on diabetes, multiple sclerosis, inflammatory bowel disease, uveitis, and lupus. A major theme will be the underlying tolerance pathways, as well as how they are subverted. Finally, sessions will be devoted to new models and therapies, and a special clinical trials session will be added. A novel feature is the presentation of Lifetime Achievement Awards at the banquet. Sessions to be covered include development of the tolerance and lymphoid homeostasis, genetics of autoimmunity, immune suppression, model systems and new therapies for autoimmune diseases, with an emphasis on proof of principle and biotechnology, and clinical trial results. The goals of the meeting are: ¨ To provide an understanding of the mechanisms of immune tolerance and its breakdown ¨ To update the audience on autoimmune models and clinical trials. ¨ To stimulate interactions between basic and clinical scientists, as well as R & D scientists in industry, from around the globe to collaborate to respond to the challenges in this area.
Discounted Abstract Deadline: September 16 2002
Discounted Registration Deadline: November 7 2002
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1 R13 AI0853209-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, January 07 | 3:00PM - 7:00PM
Registration
Room: Ballroom Lobby


Tuesday, January 07 | 6:15PM - 7:15PM
Welcome
Room: Ballroom Mezzanine


Tuesday, January 07 | 7:15PM - 7:30PM
Orientation
Room: Ballroom 2-3


Tuesday, January 07 | 7:30PM - 8:30PM
Keynote Address
Room: Ballroom 2-3

Speaker 1 of 1
James P. Allison, University of Texas MD Anderson Cancer Center, USA
Regulation of Immune Responses by CTLA-4

Wednesday, January 08 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff, Superior, Superior Lobby


Wednesday, January 08 | 8:00AM - 12:00PM
Development of the Repertoire, Homeostasis and Tolerance
Room: Ballroom 2-3

Speaker 1 of 6
* Mark J. Shlomchik, University of Pittsburgh School of Medicine, USA
Regulation and Activation of Autoreactive B Cells in Autoimmunity

Wednesday, January 08 | 8:00AM - 12:00PM
Development of the Repertoire, Homeostasis and Tolerance
Room: Ballroom 2-3

Speaker 2 of 6
Pamela J. Fink, University of Washington, USA
Induction of Peripheral T Cell Tolerance Through Antigen Receptor Revision

Wednesday, January 08 | 8:00AM - 12:00PM
Development of the Repertoire, Homeostasis and Tolerance
Room: Ballroom 2-3

Speaker 3 of 6
Josef M. Penninger, Institute of Molecular Biotechnology GmbH, Austria
Cbl and Friends: Controlling Autoimmunity and T Cell Activation

Wednesday, January 08 | 8:00AM - 12:00PM
Development of the Repertoire, Homeostasis and Tolerance
Room: Ballroom 2-3

Speaker 4 of 6
C. Garrison Fathman, Stanford University, USA
GRAIL: A Novel E3 Ligase Related to Anergy in CD4+ Lymphocytes

Wednesday, January 08 | 8:00AM - 12:00PM
Development of the Repertoire, Homeostasis and Tolerance
Room: Ballroom 2-3

Speaker 5 of 6
Joan Goverman, University of Washington, USA
Immune Tolerance to Myelin Basic Protein

Wednesday, January 08 | 8:00AM - 12:00PM
Development of the Repertoire, Homeostasis and Tolerance
Room: Ballroom 2-3

Speaker 6 of 6
Mark S. Anderson, University of California, San Francisco, USA
Short Talk: Immune Tolerance Defects in Aire-Deficient Mice

Wednesday, January 08 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Mezzanine


Wednesday, January 08 | 12:00PM - 1:00PM
Poster Setup
Room: Wasatch, Maybird, Superior, Superior Lobby


Wednesday, January 08 | 1:00PM - 10:30PM
Poster Viewing
Room: Wasatch, Maybird, Superior, Superior Lobby


Wednesday, January 08 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Ballroom Mezzanine


Wednesday, January 08 | 5:00PM - 6:00PM
Plenary Speaker Day 1
Room: Ballroom 2-3

Speaker 1 of 1
Marc K. Jenkins, University of Minnesota Medical School, USA
Mechanisms of CD4 T Cell Tolerance Induced by Antigen-Presentation without Inflammation

Wednesday, January 08 | 6:00PM - 7:00PM
Social Hour
Room: Maybird, Superior, Superior Lobby


Wednesday, January 08 | 7:00PM - 8:30PM
Poster Session 1
Room: Wasatch, Maybird, Superior, Superior Lobby


Wednesday, January 08 | 8:30PM - 10:30PM
Workshop 1: Repertoire Development and Central Tolerance
Room: Ballroom 2

Speaker 1 of 7
Melanie S. Vacchio, National Institutes of Health, USA

Wednesday, January 08 | 8:30PM - 10:30PM
Workshop 1: Repertoire Development and Central Tolerance
Room: Ballroom 2

Speaker 2 of 7
M. Carrie Miceli, University of California, Los Angeles, USA

Wednesday, January 08 | 8:30PM - 10:30PM
Workshop 1: Repertoire Development and Central Tolerance
Room: Ballroom 2

Speaker 3 of 7
Brian W. Busser, University of Pennsylvania, USA

Wednesday, January 08 | 8:30PM - 10:30PM
Workshop 1: Repertoire Development and Central Tolerance
Room: Ballroom 2

Speaker 4 of 7
Janson Leung, University of Oxford, UK

Wednesday, January 08 | 8:30PM - 10:30PM
Workshop 1: Repertoire Development and Central Tolerance
Room: Ballroom 2

Speaker 5 of 7
Jerold G. Woodward, University of Kentucky Medical Center, USA

Wednesday, January 08 | 8:30PM - 10:30PM
Workshop 1: Repertoire Development and Central Tolerance
Room: Ballroom 2

Speaker 6 of 7
Eli E. Sercarz, Torrey Pines Institute for Molecular Studies, USA

Wednesday, January 08 | 8:30PM - 10:30PM
Workshop 1: Repertoire Development and Central Tolerance
Room: Ballroom 2

Speaker 7 of 7
* Joan Goverman, University of Washington, USA

Wednesday, January 08 | 8:30PM - 10:30PM
Workshop 2: Apoptosis and Homeostasis in the Immune System
Room: Ballroom 3

Speaker 1 of 9
* Charles D. Surh, La Jolla Institute for Allergy and Immunology, USA

Wednesday, January 08 | 8:30PM - 10:30PM
Workshop 2: Apoptosis and Homeostasis in the Immune System
Room: Ballroom 3

Speaker 2 of 9
Booki Min, Lerner Research Institute, Cleveland Clinic Foundation, USA

Wednesday, January 08 | 8:30PM - 10:30PM
Workshop 2: Apoptosis and Homeostasis in the Immune System
Room: Ballroom 3

Speaker 3 of 9
Dario A. A. Vignali, University of Pittsburgh School of Medicine, USA

Wednesday, January 08 | 8:30PM - 10:30PM
Workshop 2: Apoptosis and Homeostasis in the Immune System
Room: Ballroom 3

Speaker 4 of 9
Michelle L. Hermiston, University of California, San Francisco, USA

Wednesday, January 08 | 8:30PM - 10:30PM
Workshop 2: Apoptosis and Homeostasis in the Immune System
Room: Ballroom 3

Speaker 5 of 9
Yonglian Sun, University of Chicago, USA

Wednesday, January 08 | 8:30PM - 10:30PM
Workshop 2: Apoptosis and Homeostasis in the Immune System
Room: Ballroom 3

Speaker 6 of 9
Christopher M. Snyder, Thomas Jefferson University, USA

Wednesday, January 08 | 8:30PM - 10:30PM
Workshop 2: Apoptosis and Homeostasis in the Immune System
Room: Ballroom 3

Speaker 7 of 9
Elliot T. Stevens, University of Nebraska Medical Center, USA

Wednesday, January 08 | 8:30PM - 10:30PM
Workshop 2: Apoptosis and Homeostasis in the Immune System
Room: Ballroom 3

Speaker 8 of 9
Kiley R. Prilliman, La Jolla Institute for Allergy and Immunology, USA

Wednesday, January 08 | 8:30PM - 10:30PM
Workshop 2: Apoptosis and Homeostasis in the Immune System
Room: Ballroom 3

Speaker 9 of 9
Sarah Cabbage, University of Washington, USA



Thursday, January 09 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff, Superior, Superior Lobby


Thursday, January 09 | 8:00AM - 12:00PM
Genetics, Genomics and Autoimmune Disease
Room: Ballroom 2-3

Speaker 1 of 6
* Edward K. Wakeland, University of Texas Southwestern Medical Center, USA
Genetics of Lupus

Thursday, January 09 | 8:00AM - 12:00PM
Genetics, Genomics and Autoimmune Disease
Room: Ballroom 2-3

Speaker 2 of 6
Chella S. David, Mayo Clinic, USA
Role of HLA-DQ and -DR Genes in Human Autoimmune Diseases. Studies with Transgenic/Knock-Out Mice


Thursday, January 09 | 8:00AM - 12:00PM
Genetics, Genomics and Autoimmune Disease
Room: Ballroom 2-3

Speaker 3 of 6
Vijay K. Kuchroo, Brigham and Women's Hospital, Harvard Medical School, USA
Role of Th1 Specific Cell Surface Molecule TIM-3 in Regulating Autoimmunity, Asthma and Allergies

Thursday, January 09 | 8:00AM - 12:00PM
Genetics, Genomics and Autoimmune Disease
Room: Ballroom 2-3

Speaker 4 of 6
Pere Santamaria, University of Calgary, Canada
Recruitment of Dominant Autoreactive CD8+ T Cells in Type 1 Diabetes: A Love-Hate Affair with Dendritic Cells, Regulatory T Cells and T Helper

Thursday, January 09 | 8:00AM - 12:00PM
Genetics, Genomics and Autoimmune Disease
Room: Ballroom 2-3

Speaker 5 of 6
* Linda S. Wicker, University of Cambridge, UK
Defining Idd Genes in the NOD Model of Type 1 Diabetes

Thursday, January 09 | 8:00AM - 12:00PM
Genetics, Genomics and Autoimmune Disease
Room: Ballroom 2-3

Speaker 6 of 6
Andrew L. Mellor, Georgia Regents University, USA
Short Talk: Potential Regulatory Dendritic Cells Expressing IDO

Thursday, January 09 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Mezzanine


Thursday, January 09 | 10:00AM - 10:00AM
Therapeutic Agents for Limiting Autoimmune Responses

Speaker 1 of 3
Martin Drage, University of Cambridge, UK

Thursday, January 09 | 10:00AM - 10:00AM
Therapeutic Agents for Limiting Autoimmune Responses

Speaker 2 of 3
Jeffrey L. Browning, Boston University School of Medicine, USA

Thursday, January 09 | 10:00AM - 10:00AM
Therapeutic Agents for Limiting Autoimmune Responses

Speaker 3 of 3
Ann Herman, Genentech, USA

Thursday, January 09 | 10:00AM - 10:00AM
Cell Bases Approaches to Blunt Autoimmune Responses

Speaker 1 of 3
Mandy L. Ford, Emory University, USA

Thursday, January 09 | 10:00AM - 10:00AM
Cell Bases Approaches to Blunt Autoimmune Responses

Speaker 2 of 3
Amy E. Juedes, La Jolla Institute for Allergy & Immunology, USA

Thursday, January 09 | 10:00AM - 10:00AM
Cell Bases Approaches to Blunt Autoimmune Responses

Speaker 3 of 3
Tracey A. Stephens, University of Western Ontario, Canada

Thursday, January 09 | 10:00AM - 10:00AM
Mechanistic Studies: Are We Doing What We Think We Are Doing
?

Speaker 1 of 3
Clara M. Pelfrey, Cleveland Clinic Foundation, Lerner Research Institute, USA

Thursday, January 09 | 10:00AM - 10:00AM
Mechanistic Studies: Are We Doing What We Think We Are Doing
?

Speaker 2 of 3
Liliana Graciela Petrich de Marquesini, University of Bristol, UK

Thursday, January 09 | 10:00AM - 10:00AM
Mechanistic Studies: Are We Doing What We Think We Are Doing
?

Speaker 3 of 3
Jack A. Ragheb, FDA, USA

Thursday, January 09 | 12:00PM - 1:00PM
Poster Setup
Room: Wasatch, Maybird, Superior, Superior Lobby


Thursday, January 09 | 1:00PM - 10:30PM
Poster Viewing
Room: Wasatch, Maybird, Superior, Superior Lobby


Thursday, January 09 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Ballroom Mezzanine


Thursday, January 09 | 5:00PM - 6:00PM
Plenary Speaker Day 2
Room: Ballroom 2-3

Speaker 1 of 1
Christopher C. Goodnow, Garvan Institute of Medical Research, Australia
Tolerogenic versus Immunogenic Signaling

Thursday, January 09 | 6:00PM - 7:00PM
Social Hour
Room: Maybird, Superior, Superior Lobby


Thursday, January 09 | 7:00PM - 8:30PM
Poster Session 2
Room: Wasatch, Maybird, Superior, Superior Lobby


Thursday, January 09 | 8:30PM - 10:30PM
Workshop 3: Genomics and Autoimmunity
Room: Ballroom 2

Speaker 1 of 8
* Linda S. Wicker, University of Cambridge, UK

Thursday, January 09 | 8:30PM - 10:30PM
Workshop 3: Genomics and Autoimmunity
Room: Ballroom 2

Speaker 2 of 8
Maria Halonen, National Public Health Institute, Finland

Thursday, January 09 | 8:30PM - 10:30PM
Workshop 3: Genomics and Autoimmunity
Room: Ballroom 2

Speaker 3 of 8
Raffaele Badolato, Universita di Brescia, Italy

Thursday, January 09 | 8:30PM - 10:30PM
Workshop 3: Genomics and Autoimmunity
Room: Ballroom 2

Speaker 4 of 8
Tanja Ilmarinen, National Public Health Institute, Finland

Thursday, January 09 | 8:30PM - 10:30PM
Workshop 3: Genomics and Autoimmunity
Room: Ballroom 2

Speaker 5 of 8
Paula Y. Arnold, St. Jude Children's Research Hospital, USA

Thursday, January 09 | 8:30PM - 10:30PM
Workshop 3: Genomics and Autoimmunity
Room: Ballroom 2

Speaker 6 of 8
Lynda Bennett, Baylor Institute for Immunology Research, USA

Thursday, January 09 | 8:30PM - 10:30PM
Workshop 3: Genomics and Autoimmunity
Room: Ballroom 2

Speaker 7 of 8
Jennifer H. Anolik, University of Rochester, USA

Thursday, January 09 | 8:30PM - 10:30PM
Workshop 3: Genomics and Autoimmunity
Room: Ballroom 2

Speaker 8 of 8
Philip L. Kong, Kennedy Institute of Rheumatology, UK

Thursday, January 09 | 8:30PM - 10:30PM
Workshop 4: Immunotherapy: Animal Models to Clinical Trials
Room: Ballroom 3

Speaker 1 of 2
* David M. Harlan, National Institutes of Health, NIDDK, USA

Thursday, January 09 | 8:30PM - 10:30PM
Workshop 4: Immunotherapy: Animal Models to Clinical Trials
Room: Ballroom 3

Speaker 2 of 2
* Vijay K. Kuchroo, Brigham and Women's Hospital, Harvard Medical School, USA

Friday, January 10 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff, Superior, Superior Lobby


Friday, January 10 | 8:00AM - 12:00PM
Suppression and Regulation of the Immune System
Room: Ballroom 2-3

Speaker 1 of 6
Jean François Bach, American Autoimmune Related Diseases Association, Inc., USA
Immunotherapy of Diabetes by Stimulation of Regulatory T Cells

Friday, January 10 | 8:00AM - 12:00PM
Suppression and Regulation of the Immune System
Room: Ballroom 2-3

Speaker 2 of 6
* Terry L. Delovitch, John P. Robarts Research Institute and University of Western Ontario, Canada
Protection Against Type 1 Diabetes by Regulation of NKT Cell, IL-16 and CCL4 Activity

Friday, January 10 | 8:00AM - 12:00PM
Suppression and Regulation of the Immune System
Room: Ballroom 2-3

Speaker 3 of 6
Ethan M. Shevach, NIAID, National Institutes of Health, USA
The Pleiotropic Effects of CD4+CD25+ Suppressor T Cells on Immune Responses

Friday, January 10 | 8:00AM - 12:00PM
Suppression and Regulation of the Immune System
Room: Ballroom 2-3

Speaker 4 of 6
Joost J. Oppenheim, National Institutes of Health, USA
Intolerance to Autoantigens Based on Interactions with Dendritic Cell Receptors

Friday, January 10 | 8:00AM - 12:00PM
Suppression and Regulation of the Immune System
Room: Ballroom 2-3

Speaker 5 of 6
Fiona M. Powrie, University of Oxford, UK
Control of Immune Pathology by CD4+CD25+ TR Cells

Friday, January 10 | 8:00AM - 12:00PM
Suppression and Regulation of the Immune System
Room: Ballroom 2-3

Speaker 6 of 6
* Douglas R. Green, St. Jude Children's Research Hospital, USA
Regulation of Tolerance by Suppression and Apoptosis

Friday, January 10 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Mezzanine


Friday, January 10 | 12:00PM - 1:00PM
Poster Setup
Room: Wasatch, Maybird, Superior, Superior Lobby


Friday, January 10 | 1:00PM - 10:30PM
Poster Viewing
Room: Wasatch, Maybird, Superior, Superior Lobby


Friday, January 10 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Ballroom Mezzanine


Friday, January 10 | 5:00PM - 6:00PM
Plenary Speaker Day 3
Room: Ballroom 2-3

Speaker 1 of 1
Anne O'Garra, Francis Crick Institute, UK
Development and Function of IL-10-Producing Regulatory CD4+ T Cells

Friday, January 10 | 6:00PM - 7:00PM
Social Hour
Room: Maybird, Superior, Superior Lobby


Friday, January 10 | 7:00PM - 8:30PM
Poster Session 3
Room: Wasatch, Maybird, Superior, Superior Lobby


Friday, January 10 | 8:30PM - 10:30PM
Workshop 5: Role of the APC in Tolerance
Room: Ballroom 2

Speaker 1 of 8
* Stephen D. Miller, Northwestern University Medical School, USA

Friday, January 10 | 8:30PM - 10:30PM
Workshop 5: Role of the APC in Tolerance
Room: Ballroom 2

Speaker 2 of 8
Lucy S. K. Walker, University College London, UK

Friday, January 10 | 8:30PM - 10:30PM
Workshop 5: Role of the APC in Tolerance
Room: Ballroom 2

Speaker 3 of 8
Kenneth S. Tung, University of Virginia, USA

Friday, January 10 | 8:30PM - 10:30PM
Workshop 5: Role of the APC in Tolerance
Room: Ballroom 2

Speaker 4 of 8
Susmit Suvas, Oakland University, USA

Friday, January 10 | 8:30PM - 10:30PM
Workshop 5: Role of the APC in Tolerance
Room: Ballroom 2

Speaker 5 of 8
Michele M. Kosiewicz, University of Louisville, USA

Friday, January 10 | 8:30PM - 10:30PM
Workshop 5: Role of the APC in Tolerance
Room: Ballroom 2

Speaker 6 of 8
Janet Liversidge, University of Aberdeen, UK

Friday, January 10 | 8:30PM - 10:30PM
Workshop 5: Role of the APC in Tolerance
Room: Ballroom 2

Speaker 7 of 8
Birgit Knoechel, Dana-Farber Cancer Institute, USA

Friday, January 10 | 8:30PM - 10:30PM
Workshop 5: Role of the APC in Tolerance
Room: Ballroom 2

Speaker 8 of 8
Leon L. Su, Stanford University, USA

Friday, January 10 | 8:30PM - 10:30PM
Workshop 6: Critical Factors in the Activation of Autoreacti
ve T and B Cells
Room: Ballroom 3

Speaker 1 of 8
* Mark J. Shlomchik, University of Pittsburgh School of Medicine, USA

Friday, January 10 | 8:30PM - 10:30PM
Workshop 6: Critical Factors in the Activation of Autoreacti
ve T and B Cells
Room: Ballroom 3

Speaker 2 of 8
Todd N. Eagar, University of California, San Francisco, USA

Friday, January 10 | 8:30PM - 10:30PM
Workshop 6: Critical Factors in the Activation of Autoreacti
ve T and B Cells
Room: Ballroom 3

Speaker 3 of 8
Lesley Young, UK

Friday, January 10 | 8:30PM - 10:30PM
Workshop 6: Critical Factors in the Activation of Autoreacti
ve T and B Cells
Room: Ballroom 3

Speaker 4 of 8
Stephen M. Anderton, University of Edinburgh, UK

Friday, January 10 | 8:30PM - 10:30PM
Workshop 6: Critical Factors in the Activation of Autoreacti
ve T and B Cells
Room: Ballroom 3

Speaker 5 of 8
Haoli Jin, University of Miami School of Medicine, USA

Friday, January 10 | 8:30PM - 10:30PM
Workshop 6: Critical Factors in the Activation of Autoreacti
ve T and B Cells
Room: Ballroom 3

Speaker 6 of 8
Francoise Lepault, INSERM, France

Friday, January 10 | 8:30PM - 10:30PM
Workshop 6: Critical Factors in the Activation of Autoreacti
ve T and B Cells
Room: Ballroom 3

Speaker 7 of 8
Thomas A. Ferguson, Washington University School of Medicine, USA

Friday, January 10 | 8:30PM - 10:30PM
Workshop 6: Critical Factors in the Activation of Autoreacti
ve T and B Cells
Room: Ballroom 3

Speaker 8 of 8
Jinyoung Choi, Yale University, USA

Saturday, January 11 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff, Superior, Superior Lobby


Saturday, January 11 | 8:00AM - 12:00PM
Immune Modulation of Inflammation and Autoimmunity
Room: Ballroom 2-3

Speaker 1 of 6
* David W. Scott, Uniformed Services University of Health Sciences, USA
Gene Therapy for Tolerance and Vice Versa

Saturday, January 11 | 8:00AM - 12:00PM
Immune Modulation of Inflammation and Autoimmunity
Room: Ballroom 2-3

Speaker 2 of 6
Anne Cooke, University of Cambridge, UK
The Relationship between Infection and Type 1 Diabetes


Saturday, January 11 | 8:00AM - 12:00PM
Immune Modulation of Inflammation and Autoimmunity
Room: Ballroom 2-3

Speaker 3 of 6
* Rachel R. Caspi, NEI, National Institutes of Health, USA
Central and Peripheral Mechanisms in Tolerance to Immunologically Privileged Retinal Antigens

Saturday, January 11 | 8:00AM - 12:00PM
Immune Modulation of Inflammation and Autoimmunity
Room: Ballroom 2-3

Speaker 4 of 6
David C. Wraith, University of Bristol, UK
Designing Peptides for Therapy of Autoimmune Diseases

Saturday, January 11 | 8:00AM - 12:00PM
Immune Modulation of Inflammation and Autoimmunity
Room: Ballroom 2-3

Speaker 5 of 6
George C. Tsokos, Beth Israel Deaconess Medical Center, USA
Short Talk: T Cell Receptor Rewiring in Autoimmmune Disease: The Story of Two Chains

Saturday, January 11 | 8:00AM - 12:00PM
Immune Modulation of Inflammation and Autoimmunity
Room: Ballroom 2-3

Speaker 6 of 6
Matthias G. von Herrath, Novo Nordisk and La Jolla Institute for Allergy and Immunology, USA
Short Talk: Immunizing with APCs against Autoimmunity

Saturday, January 11 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Mezzanine


Saturday, January 11 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Ballroom Mezzanine


Saturday, January 11 | 5:00PM - 6:00PM
Plenary Speaker Day 4
Room: Ballroom 2-3

Speaker 1 of 1
Michael J. Lenardo, NIAID, National Institutes of Health, USA
The Dual Role of Caspases in Cell Death and Proliferation

Saturday, January 11 | 6:00PM - 7:00PM
Social Hour
Room: Maybird, Superior, Superior Lobby


Sunday, January 12 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff, Superior, Superior Lobby


Sunday, January 12 | 8:00AM - 12:00PM
Clinical Trials for Autoimmune Diseases. Session Sponsored
by the Juvenile Diabetes Research Foundation International.

Room: Ballroom 2-3

Speaker 1 of 6
* David M. Harlan, National Institutes of Health, NIDDK, USA
Immunotherapeutic Diabetes Trials at the NIH

Sunday, January 12 | 8:00AM - 12:00PM
Clinical Trials for Autoimmune Diseases. Session Sponsored
by the Juvenile Diabetes Research Foundation International.

Room: Ballroom 2-3

Speaker 2 of 6
Breay W. Paty, University of Alberta, Canada
Islet Transplantation: The Edmonton Experience

Sunday, January 12 | 8:00AM - 12:00PM
Clinical Trials for Autoimmune Diseases. Session Sponsored
by the Juvenile Diabetes Research Foundation International.

Room: Ballroom 2-3

Speaker 3 of 6
Gerald T. Nepom, Benaroya Research Institute, USA
Tracking Autoantigen-Specific Responses

Sunday, January 12 | 8:00AM - 12:00PM
Clinical Trials for Autoimmune Diseases. Session Sponsored
by the Juvenile Diabetes Research Foundation International.

Room: Ballroom 2-3

Speaker 4 of 6
Richard K. Burt, Northwestern University, USA
Clinical Trials Using Stem Cells to Induce Tolerance

Sunday, January 12 | 8:00AM - 12:00PM
Clinical Trials for Autoimmune Diseases. Session Sponsored
by the Juvenile Diabetes Research Foundation International.

Room: Ballroom 2-3

Speaker 5 of 6
David A. Hafler, Yale University School of Medicine, USA
Higher Strength of Signals Delivered to Responder T Cells Prevents Suppression by Regulatory CD4+CD25+ T Cells


Sunday, January 12 | 8:00AM - 12:00PM
Clinical Trials for Autoimmune Diseases. Session Sponsored
by the Juvenile Diabetes Research Foundation International.

Room: Ballroom 2-3

Speaker 6 of 6
* Jeffrey A. Bluestone, University of California, San Francisco, USA
Clinical Trials with Anti-CD3 in Type 1 Diabetes

Sunday, January 12 | 9:00AM - 12:00PM
Entertainment
Room: Ballroom 2-3


Sunday, January 12 | 9:00AM - 12:00PM
Cash Bar
Room: Ballroom 2-3


Sunday, January 12 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Mezzanine


Sunday, January 12 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Ballroom Mezzanine


Sunday, January 12 | 5:00PM - 6:00PM
Special Lifetime Achievement Awards
Room: Ballroom 2-3

Speaker 1 of 1
Ray D. Owen, California Institute of Technology, USA
Twin Calves, Tolerance and Beyond

Sunday, January 12 | 7:00PM - 8:00PM
Social Hour
Room: Ballroom Mezzanine


Sunday, January 12 | 8:00PM - 10:00PM
Banquet
Room: Ballroom 2-3


Monday, January 13 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.