Web Desc
New Advances in Drug Discovery
Organizer(s): James A. Wells and Robert F.G. Booth
Date: January 07 - 12, 2003
Location: Yarrow Resort Hotel, Park City, UT, USA
Sponsored by ICOS Corporation
Summary of Meeting:
The Keystone Meeting on New Advances in Drug Discovery is held every other year and is intended to capture the most exciting developments in Industry and Academia related to Drug Discovery. The meeting has traditionally been one of the most dynamic Keystone conferences because of the cross-section of scientists that are assembled to discuss key advances in biopharmaceutical sciences. There are now many opportunities to enhance drug discovery through the utilization of data from the Human Genome Project and through new tools designed to exploit the information. In addition, a variety of novel technologies are emerging which promise to enhance the productivity of drug discovery. All of this is fueled by the need to improve the efficiency of drug discovery. It is the objective of this meeting to focus on the most exciting new technologies, trends and potential success stories in novel areas of drug discovery. Rather than providing broad reviews of general fields or company overviews, the meeting is intended to provide new scientific achievements in the area of biomedical and pharmaceutical research. The meeting will include new breakthroughs in the following areas: New approaches to the discovery of small molecules The impact of genomics and proteomics to drug discovery Emerging target classes New drug candidates In the first part of the meeting the focus will be on the ways in which structural, computational and combinatorial approaches have improved our ability to design small molecules, both in terms of speed and quality. The session on genomics will provide information on the latest advances in these fields and their impact on our understanding of the biology emerging from the human genome project. The ability of these technologies to aid in the identification of attractive new drug targets will be assessed. The majority of small molecule drugs reaching the market have focused on a very limited set of target classes (GPCRs, proteases etc). The third session will focus on newly emerging target classes and the progress that is being made to bring molecules from these classes through to the clinic. The final session will assess the progress that is being made on some of the most exciting targets being focused on within drug discovery. The lessons which can be learned from the hard won experience of this work will be reviewed. In summary, the most exciting current research in emerging fields of drug discovery will be covered during the course of the meeting.
Discounted Abstract Deadline: September 16 2002
Discounted Registration Deadline: November 7 2002
We gratefully acknowledge additional support for this conference from:

Cell Signaling Technology, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1 R13 CA098965-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, January 07 | 3:00PM - 7:00PM
Registration
Room: Lobby


Tuesday, January 07 | 6:15PM - 7:15PM
Welcome Reception
Room: Summit C


Tuesday, January 07 | 7:15PM - 7:30PM
Orientation
Room: Summit A-B


Tuesday, January 07 | 7:30PM - 8:30PM
Keynote Address
Room: Summit A-B

Speaker 1 of 2
* James A. Wells, University of California, San Francisco, USA

Tuesday, January 07 | 7:30PM - 8:30PM
Keynote Address
Room: Summit A-B

Speaker 2 of 2
Edward M. Skolnick, USA
Basic Science to Outcomes for Patients

Wednesday, January 08 | 7:00AM - 8:00AM
Breakfast
Room: Ivers/Hearst/Kearns & Mountain View


Wednesday, January 08 | 8:00AM - 11:00AM
New Approaches to Small Molecule Drug Discovery I
Room: Summit A-B

Speaker 1 of 5
* James A. Wells, University of California, San Francisco, USA

Wednesday, January 08 | 8:00AM - 11:00AM
New Approaches to Small Molecule Drug Discovery I
Room: Summit A-B

Speaker 2 of 5
Wayne A. Hendrickson, Columbia University, USA
Role of Structural Genomics in Drug Discovery

Wednesday, January 08 | 8:00AM - 11:00AM
New Approaches to Small Molecule Drug Discovery I
Room: Summit A-B

Speaker 3 of 5
Ruben Abagyan, University of California, San Diego, USA
Docking and Virtual Screening in Lead Drug Discovery

Wednesday, January 08 | 8:00AM - 11:00AM
New Approaches to Small Molecule Drug Discovery I
Room: Summit A-B

Speaker 4 of 5
Steven A. Hofstadler, Ibis Therapeutics, USA
Drug Discovery for Structured RNA Targets

Wednesday, January 08 | 8:00AM - 11:00AM
New Approaches to Small Molecule Drug Discovery I
Room: Summit A-B

Speaker 5 of 5
Robert McDowell, MyoKardia Inc, USA
Discovering Drugs from Fragments

Wednesday, January 08 | 9:20AM - 9:40AM
Coffee Break
Room: Summit Hallway


Wednesday, January 08 | 11:00AM - 1:00PM
Poster Setup
Room: Summit C


Wednesday, January 08 | 1:00PM - 7:30PM
Poster Session 1 Open Viewing
Room: Summit C


Wednesday, January 08 | 4:15PM - 4:30PM
Coffee & Snacks Available
Room: Summit Hallway


Wednesday, January 08 | 4:30PM - 6:30PM
New Approaches to Small Molecule Drug Discovery II
Room: Summit A-B

Speaker 1 of 5
* Michelle F. Browner, Johnson & Johnson Innovation, USA

Wednesday, January 08 | 4:30PM - 6:30PM
New Approaches to Small Molecule Drug Discovery II
Room: Summit A-B

Speaker 2 of 5
Steven V. Ley, University of Cambridge, UK
Parallel Skiing: An Essential Component of Good Parallel Synthesis

Wednesday, January 08 | 4:30PM - 6:30PM
New Approaches to Small Molecule Drug Discovery II
Room: Summit A-B

Speaker 3 of 5
Lutz Weber, Morphochem AG, Germany
The Evolution of Combinatorial Libraries

Wednesday, January 08 | 4:30PM - 6:30PM
New Approaches to Small Molecule Drug Discovery II
Room: Summit A-B

Speaker 4 of 5
Stephen G. Sligar, University of Illinois at Urbana-Champaign, USA
Short Talk: Self-Assembly of Integral Membrane Proteins into Soluble, Homogeneous Nanometer Scale Phospholipid Bilayer Disk

Wednesday, January 08 | 4:30PM - 6:30PM
New Approaches to Small Molecule Drug Discovery II
Room: Summit A-B

Speaker 5 of 5
Michael W. Pantoliano, Millennium Pharmaceuticals, Inc., USA
Short Talk: Drug Discovery Applications of Microfluidics Technology for Kinases

Wednesday, January 08 | 6:30PM - 7:30PM
Social Hour
Room: Summit C


Wednesday, January 08 | 6:30PM - 7:30PM
Poster Session 1: New Approaches to Small Molecule Drug Disc
overy
Room: Summit C


Thursday, January 09 | 7:00AM - 8:00AM
Breakfast
Room: Ivers/Hearst/Kearns & Mountain View


Thursday, January 09 | 8:00AM - 11:00AM
Impact of Proteomics and Genomics on Drug Discovery I
Room: Summit A-B

Speaker 1 of 5
* N. Leigh Anderson, SISCAPA Assay Technologies, Inc., USA

Thursday, January 09 | 8:00AM - 11:00AM
Impact of Proteomics and Genomics on Drug Discovery I
Room: Summit A-B

Speaker 2 of 5
John W. Kozarich, ActivX Biosciences, Inc., USA
Activity-Based Proteomics: Enzyme Chemistry Redux

Thursday, January 09 | 8:00AM - 11:00AM
Impact of Proteomics and Genomics on Drug Discovery I
Room: Summit A-B

Speaker 3 of 5
Stephen P.A. Fodor, Cellular Research, Inc., USA
Accessing the Genome

Thursday, January 09 | 8:00AM - 11:00AM
Impact of Proteomics and Genomics on Drug Discovery I
Room: Summit A-B

Speaker 4 of 5
Michael V. Milburn, Metabolon, USA
Scaffold-Based Drug Discovery

Thursday, January 09 | 8:00AM - 11:00AM
Impact of Proteomics and Genomics on Drug Discovery I
Room: Summit A-B

Speaker 5 of 5
Ian McCaffery, Celera Genomics, USA
Target Discovery: The Cell Surface

Thursday, January 09 | 9:20AM - 9:40AM
Coffee Break
Room: Summit Hallway


Thursday, January 09 | 11:00AM - 1:00PM
Poster Setup
Room: Summit C


Thursday, January 09 | 1:00PM - 7:30PM
Poster Session 2 Open Viewing
Room: Summit C


Thursday, January 09 | 4:15PM - 4:30PM
Coffee & Snacks Available
Room: Summit Hallway


Thursday, January 09 | 4:30PM - 6:30PM
Impact of Proteomics and Genomics on Drug Discovery II
Room: Summit A-B

Speaker 1 of 4
* Christine M. Debouck, Ardennes Biosciences LLC, USA

Thursday, January 09 | 4:30PM - 6:30PM
Impact of Proteomics and Genomics on Drug Discovery II
Room: Summit A-B

Speaker 2 of 4
David Eisenberg, University of California, Los Angeles, USA
Defining Interacting Partners

Thursday, January 09 | 4:30PM - 6:30PM
Impact of Proteomics and Genomics on Drug Discovery II
Room: Summit A-B

Speaker 3 of 4
Michael P. Snyder, Stanford University School of Medicine, USA
Global Analysis of Protein Activities Using Protein Chips

Thursday, January 09 | 4:30PM - 6:30PM
Impact of Proteomics and Genomics on Drug Discovery II
Room: Summit A-B

Speaker 4 of 4
Mark W. Moore, Deltagen, Inc., USA
From the Genome to Drug Targets via High Throughput Gene Knockouts and Systematic Phenotyping

Thursday, January 09 | 6:30PM - 7:30PM
Social Hour
Room: Summit C


Thursday, January 09 | 6:30PM - 7:30PM
Poster Session 2: Impact of Proteomics on Drug Discovery
Room: Summit C


Thursday, January 09 | 9:00PM - 10:00PM
Panel Discussion: Bottlenecks in Drug Discovery
Room: Summit A-B

Speaker 1 of 1
* Brian W. Metcalf, Global Blood Therapeutics, USA

Friday, January 10 | 7:00AM - 8:00AM
Breakfast
Room: Ivers/Hearst/Kearns & Mountain View


Friday, January 10 | 8:00AM - 11:00AM
Emerging Target Classes I . Session Sponsored in part by Ce
ll Signaling Technology.

Room: Summit A-B

Speaker 1 of 5
* Brian W. Metcalf, Global Blood Therapeutics, USA

Friday, January 10 | 8:00AM - 11:00AM
Emerging Target Classes I . Session Sponsored in part by Ce
ll Signaling Technology.

Room: Summit A-B

Speaker 2 of 5
Joshua Boger, Vertex Pharmaceuticals Incorporated, USA
Human Protein Kinases: A Chemogenomics Approach

Friday, January 10 | 8:00AM - 11:00AM
Emerging Target Classes I . Session Sponsored in part by Ce
ll Signaling Technology.

Room: Summit A-B

Speaker 3 of 5
Kenneth W. Wood, Cytokinetics Inc., USA
Mitotic Kinesin-Targeted Anti-Tumor Agents

Friday, January 10 | 8:00AM - 11:00AM
Emerging Target Classes I . Session Sponsored in part by Ce
ll Signaling Technology.

Room: Summit A-B

Speaker 4 of 5
Timothy M. Willson, GlaxoSmithKline, USA
Chemical and Structural Genomics of Orphan Nuclear Receptors

Friday, January 10 | 8:00AM - 11:00AM
Emerging Target Classes I . Session Sponsored in part by Ce
ll Signaling Technology.

Room: Summit A-B

Speaker 5 of 5
Nicholas K. Tonks, Cold Spring Harbor Laboratory, USA
The Protein Tyrosine Biosphases as a Platform for Development of Novel Therapeutics

Friday, January 10 | 9:20AM - 9:40AM
Coffee Break
Room: Summit Hallway


Friday, January 10 | 11:00AM - 1:00PM
Poster Setup
Room: Summit C


Friday, January 10 | 1:00PM - 7:30PM
Poster Session 3 Open Viewing
Room: Summit C


Friday, January 10 | 4:15PM - 4:30PM
Coffee & Snacks Available
Room: Summit Hallway


Friday, January 10 | 4:30PM - 6:30PM
Emerging Target Classes II
Room: Summit Hallway

Speaker 1 of 5
* Leslie J. Browne, Senesco Technologies, Inc., USA

Friday, January 10 | 4:30PM - 6:30PM
Emerging Target Classes II
Room: Summit Hallway

Speaker 2 of 5
Thomas A. Steitz, Howard Hughes Medical Institute, Yale University, USA
The Structures of Complexes Between the H. Marismortui Large Ribosomal Subunit and Nine Antibiotics

Friday, January 10 | 4:30PM - 6:30PM
Emerging Target Classes II
Room: Summit Hallway

Speaker 3 of 5
Paul G. Polakis, Genentech, Inc., USA
Development of Antibodies for Cancer Therapy

Friday, January 10 | 4:30PM - 6:30PM
Emerging Target Classes II
Room: Summit Hallway

Speaker 4 of 5
Susan M. Molineaux, Calithera Biosciences, USA
Short Talk: Targeting Mast Cells and Allergic Diseases with Novel Small Molecular Inhibitors

Friday, January 10 | 4:30PM - 6:30PM
Emerging Target Classes II
Room: Summit Hallway

Speaker 5 of 5
Kurt Jarnagin, Anacor Pharmaceuticals, Inc., USA
Short Talk: Chemogenomics

Friday, January 10 | 6:30PM - 7:30PM
Social Hour
Room: Summit C


Friday, January 10 | 6:30PM - 7:30PM
Poster Session 3: Emerging Target Families
Room: Summit C


Saturday, January 11 | 7:00AM - 8:00AM
Breakfast
Room: Ivers/Hearst/Kearns & Mountain View


Saturday, January 11 | 8:00AM - 11:00AM
New Drug Candidates I
Room: Summit A-B

Speaker 1 of 5
* Paul A. Bartlett, University of California, Berkeley, USA

Saturday, January 11 | 8:00AM - 11:00AM
New Drug Candidates I
Room: Summit A-B

Speaker 2 of 5
Nigel Walker, Amgen Inc., USA
IKK Inhibitors

Saturday, January 11 | 8:00AM - 11:00AM
New Drug Candidates I
Room: Summit A-B

Speaker 3 of 5
David M. Goldstein, USA
Structure Guided Design as an Approach to the Discovery of Novel p38 Inhibitors

Saturday, January 11 | 8:00AM - 11:00AM
New Drug Candidates I
Room: Summit A-B

Speaker 4 of 5
Peter Traxler, Novartis Pharma AG, Switzerland
Tyrosine Kinase Inhibitors: From Research to Clinics

Saturday, January 11 | 8:00AM - 11:00AM
New Drug Candidates I
Room: Summit A-B

Speaker 5 of 5
Michael K. Trower, GlaxoSmithKline, UK
Targeting Cathepsin K as a Means to Inhibit Osteoclast Mediated Bone Resorption

Saturday, January 11 | 9:20AM - 9:40AM
Coffee Break
Room: Summit Hallway


Saturday, January 11 | 4:15PM - 4:30PM
Coffee & Snacks Available
Room: Summit Hallway


Saturday, January 11 | 4:30PM - 5:45PM
New Drug Candidates II
Room: Summit A-B

Speaker 1 of 3
* Robert F.G. Booth, Celera, USA

Saturday, January 11 | 4:30PM - 5:45PM
New Drug Candidates II
Room: Summit A-B

Speaker 2 of 3
Steven D. Young, Merck Research Laboratories, USA
HIV Integrase Inhibitors

Saturday, January 11 | 4:30PM - 5:45PM
New Drug Candidates II
Room: Summit A-B

Speaker 3 of 3
Lee E. Babiss, PPD, Inc., USA
Impact of Toxicogenomics on Drug Discovery and Development

Saturday, January 11 | 5:45PM - 6:45PM
Concluding Address
Room: Summit A-B

Speaker 1 of 2
* Robert F.G. Booth, Celera, USA

Saturday, January 11 | 5:45PM - 6:45PM
Concluding Address
Room: Summit A-B

Speaker 2 of 2
George M. Whitesides, Harvard University, USA

Saturday, January 11 | 6:45PM - 7:45PM
Social Hour
Room: Summit C


Saturday, January 11 | 7:45PM - 11:00PM
Entertainment
Room: Summit C


Saturday, January 11 | 7:45PM - 11:00PM
Cash Bar
Room: Summit C


Sunday, January 12 | 10:26AM - 10:26AM
Departure


*Session Chair.