Web Desc
Chromatin: Organizing the Genome for Patterns of Gene Expression in Health and Disease
Organizer(s): Stephen B. Baylin, Susan M. Gasser and Tony Kouzarides
Date: January 10 - 15, 2003
Location: Big Sky Resort, Big Sky, MT, USA
Sponsored in part by The Director's Sponsor Fund
Summary of Meeting:
Exciting recent advances in biology stem from our growing appreciation of how chromatin dynamically modulates the genome to program the repertoire of gene expression. To accomplish this process, which is fundamental to embryonic development and mature cell renewal and differentiation, chromatin assembly must be intimately coordinated with cell cycle control, timing of DNA replication, positioning of genes within nuclear domains, and signal transduction events guiding essential post-translational modifications of the proteins involved. Failure of any step can contribute to diseases ranging from inherited disorders to cancer. Despite the importance of the above arena, we are just beginning to understand the molecular players and their co-ordination during cell fate decisions. This meeting will bring together a diverse range of experts in developmental biology, gene transcription, chromatin modeling complexes, nuclear structure, cell cycle regulation and DNA replication, and study of these processes in disease states, to discuss the current and future status of this key cell biology arena
Discounted Abstract Deadline: September 16 2002
Discounted Registration Deadline: November 11 2002
We gratefully acknowledge additional support for this conference from:
Abcam plc
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Friday, January 10 | 3:00PM - 7:00PM
Registration
Room: Lower Atrium


Friday, January 10 | 6:15PM - 7:15PM
Welcome
Room: Upper Atrium


Friday, January 10 | 7:15PM - 7:30PM
Orientation
Room: Jefferson


Friday, January 10 | 7:30PM - 8:30PM
Keynote Address
Room: Jefferson

Speaker 1 of 1
Gary Felsenfeld, NIDDK, National Institutes of Health, USA
Chromatin Boundaries and the Regulation of Gene Expression

Saturday, January 11 | 7:00AM - 8:00AM
Breakfast
Room: Gallatin/Lake-Canyon


Saturday, January 11 | 8:00AM - 11:00AM
Histone Modification. Session Sponsored in part by Abcam, L
td.

Room: Jefferson

Speaker 5 of 5
Neil Brockdorff, University of Oxford, UK
Short Talk: Polycomb Proteins in X Chromosome Inactivation

Saturday, January 11 | 8:00AM - 11:00AM
Histone Modification. Session Sponsored in part by Abcam, L
td.

Room: Jefferson

Speaker 4 of 5
Paolo Sassone-Corsi, University of California, Irvine, USA
Signaling to Chromatin - Coupled Histone Modifications

Saturday, January 11 | 8:00AM - 11:00AM
Histone Modification. Session Sponsored in part by Abcam, L
td.

Room: Jefferson

Speaker 3 of 5
Tony Kouzarides, University of Cambridge, UK
Histone Modification in Transcriptional Control

Saturday, January 11 | 8:00AM - 11:00AM
Histone Modification. Session Sponsored in part by Abcam, L
td.

Room: Jefferson

Speaker 2 of 5
Yi Zhang, HHMI/Harvard Medical School, Children's Hospital Boston, USA
Histone Methylation and Polycomb Group Gene Silencing

Saturday, January 11 | 8:00AM - 11:00AM
Histone Modification. Session Sponsored in part by Abcam, L
td.

Room: Jefferson

Speaker 1 of 5
* Shelley L. Berger, University of Pennsylvania, USA
Covalent Modifications of Histones in Gene Activation

Saturday, January 11 | 9:20AM - 9:40AM
Coffee Break
Room: Lower Atrium


Saturday, January 11 | 11:00AM - 1:00PM
Poster Setup
Room: Gallatin


Saturday, January 11 | 1:00PM - 10:00PM
Poster Viewing
Room: Gallatin


Saturday, January 11 | 2:30PM - 4:30PM
Workshop 1: Modifying and Remodeling Enzymes
Room: Jefferson

Speaker 8 of 8
Gregory David, New York University School of Medicine, USA
Mammalian SDS3 is an Essential Component of the mSIN3/HDAC Corepressor Complex

Saturday, January 11 | 2:30PM - 4:30PM
Workshop 1: Modifying and Remodeling Enzymes
Room: Jefferson

Speaker 7 of 8
Matthew C. Lorincz, University of British Columbia, Canada
DNA Methylation Density Defines the Stability of an Epigenetic Mark and Dnmt3a/b Independent de novo Methylation

Saturday, January 11 | 2:30PM - 4:30PM
Workshop 1: Modifying and Remodeling Enzymes
Room: Jefferson

Speaker 6 of 8
François Fuks, Université Libre de Bruxelles, Belgium
Dnmt3a Associates with the Myc Oncoprotein

Saturday, January 11 | 2:30PM - 4:30PM
Workshop 1: Modifying and Remodeling Enzymes
Room: Jefferson

Speaker 5 of 8
David G. Skalnik, Indiana University, USA
Defects in Cytosine Methylation and Histone Modification in Embryonic Stem Cells Lacking CpG Binding Protein

Saturday, January 11 | 2:30PM - 4:30PM
Workshop 1: Modifying and Remodeling Enzymes
Room: Jefferson

Speaker 4 of 8
Jill A. Fahrner, Johns Hopkins School of Medicine, USA
Inhibition of DNA Methyltransferases but not Histone Deacetylases Reverses the Distinct Histone Code that Marks a Hypermethylated hMLH1 Promoter in Cancer

Saturday, January 11 | 2:30PM - 4:30PM
Workshop 1: Modifying and Remodeling Enzymes
Room: Jefferson

Speaker 3 of 8
Vincent Géli, Centre National de la Recherche Scientifique, France
The Many Faces of Set1p

Saturday, January 11 | 2:30PM - 4:30PM
Workshop 1: Modifying and Remodeling Enzymes
Room: Jefferson

Speaker 2 of 8
Orr G. Barak, Wistar Institute, USA
Identification and Characterization of a Novel Human SNF2L Containing Chromatin Remodeling Complex

Saturday, January 11 | 2:30PM - 4:30PM
Workshop 1: Modifying and Remodeling Enzymes
Room: Jefferson

Speaker 1 of 8
* Tony Kouzarides, University of Cambridge, UK

Saturday, January 11 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Lower Atrium


Saturday, January 11 | 5:00PM - 7:00PM
Chromatin Remodeling
Room: Jefferson

Speaker 2 of 4
Steven Henikoff, Fred Hutchinson Cancer Research Center, USA
Chromatin States Distinguished by Variant H3 Histones

Saturday, January 11 | 5:00PM - 7:00PM
Chromatin Remodeling
Room: Jefferson

Speaker 1 of 4
* Jerry L. Workman, Stowers Institute for Medical Research, USA
Recruitment and Interactions of Chromatin Modifying Complexes

Saturday, January 11 | 5:00PM - 7:00PM
Chromatin Remodeling
Room: Jefferson

Speaker 3 of 4
Peter B. Becker, University of Munich, Germany
Regulation of Nucleosome Mobility

Saturday, January 11 | 5:00PM - 7:00PM
Chromatin Remodeling
Room: Jefferson

Speaker 4 of 4
Jane Mellor, University of Oxford, UK
Short Talk: The Isw1p Chromatin Remodeling ATPase Configures a Promoter Proximal Nucleosome and Regulates Elongating RNA Polymesase II

Saturday, January 11 | 7:00PM - 8:00PM
Social Hour
Room: Lower Atrium/Gallatin


Saturday, January 11 | 8:00PM - 10:00PM
Poster Session 1
Room: Gallatin


Sunday, January 12 | 7:00AM - 8:00AM
Breakfast
Room: Gallatin/Lake-Canyon


Sunday, January 12 | 8:00AM - 11:00AM
Heterochromatin
Room: Jefferson

Speaker 1 of 5
* Thomas Jenuwein, Max Planck Institute of Immunobiology and Epigenetics, Germany
Epigenetic Control by Histone Methylation

Sunday, January 12 | 8:00AM - 11:00AM
Heterochromatin
Room: Jefferson

Speaker 2 of 5
Sarah C.R. Elgin, Washington University, USA
HP1, HP2 and the Organization of Heterochromatin

Sunday, January 12 | 8:00AM - 11:00AM
Heterochromatin
Room: Jefferson

Speaker 3 of 5
Jef D. Boeke, New York University Langone Medical Center, USA
Chromatin Modification in Yeast and Beyond

Sunday, January 12 | 8:00AM - 11:00AM
Heterochromatin
Room: Jefferson

Speaker 4 of 5
David C. Schultz, Case Western Reserve University, USA
Short Talk: Purification and Characterization of a Core HP1-CAF1 Complex: Implications for Maintenance of Heterochromatin Domains

Sunday, January 12 | 8:00AM - 11:00AM
Heterochromatin
Room: Jefferson

Speaker 5 of 5
Huawei Xin, Baylor College of Medicine, USA
Short Talk: Involvements of DMAP1 and p33ING1 in Heterochromatin Duplication

Sunday, January 12 | 9:20AM - 9:40AM
Coffee Break
Room: Lower Atrium


Sunday, January 12 | 11:00AM - 1:00PM
Poster Setup
Room: Gallatin


Sunday, January 12 | 1:00PM - 10:00PM
Poster Viewing
Room: Gallatin


Sunday, January 12 | 2:30PM - 4:30PM
Workshop 2: Heterochromatin, Nuclear Organization, Replicati
on and DNA Repair
Room: Jefferson

Speaker 1 of 9
* Susan M. Gasser, Friedrich Miescher Institute for Biomedical Research, Switzerland

Sunday, January 12 | 2:30PM - 4:30PM
Workshop 2: Heterochromatin, Nuclear Organization, Replicati
on and DNA Repair
Room: Jefferson

Speaker 2 of 9
Brian Burke, University of Florida, USA
A-Type Lamins and Nuclear Organization

Sunday, January 12 | 2:30PM - 4:30PM
Workshop 2: Heterochromatin, Nuclear Organization, Replicati
on and DNA Repair
Room: Jefferson

Speaker 3 of 9
Philippe Louis Clerc, Pasteur Institut, France
Functional Analysis of the Mouse X Inactivation Center through Targeted Deletions and Site Specific Transgenesis

Sunday, January 12 | 2:30PM - 4:30PM
Workshop 2: Heterochromatin, Nuclear Organization, Replicati
on and DNA Repair
Room: Jefferson

Speaker 4 of 9
Emmanuel Käs, Centre National de la Recherche Scientifique, France
A Model for the Initiation of Heterochromatin Assembly by the D1 Multi-A•T Hook Protein of Drosophila melanogaster

Sunday, January 12 | 2:30PM - 4:30PM
Workshop 2: Heterochromatin, Nuclear Organization, Replicati
on and DNA Repair
Room: Jefferson

Speaker 5 of 9
Bas van Steensel, Netherlands Cancer Institute, Netherlands
Heterochromatin Genomics in Drosophila

Sunday, January 12 | 2:30PM - 4:30PM
Workshop 2: Heterochromatin, Nuclear Organization, Replicati
on and DNA Repair
Room: Jefferson

Speaker 6 of 9
Colin L. Stewart, Institute of Medical Biology, Singapore
The Nuclear Envelope in Development and Disease

Sunday, January 12 | 2:30PM - 4:30PM
Workshop 2: Heterochromatin, Nuclear Organization, Replicati
on and DNA Repair
Room: Jefferson

Speaker 7 of 9
Hiten D. Madhani, University of California, San Francisco, USA
Inhibition of Heterochromatin Formation by an Intrinsic Component of Euchromatin

Sunday, January 12 | 2:30PM - 4:30PM
Workshop 2: Heterochromatin, Nuclear Organization, Replicati
on and DNA Repair
Room: Jefferson

Speaker 8 of 9
Amy K. Csink, Carnegie Mellon University, USA
Using Interspecific Introgression to Demonstrate the Sequence Independence of Heterochromatic Self-Association

Sunday, January 12 | 2:30PM - 4:30PM
Workshop 2: Heterochromatin, Nuclear Organization, Replicati
on and DNA Repair
Room: Jefferson

Speaker 9 of 9
Catherine A. Fox, University of Wisconsin-Madison, USA
Specifying Function of the Origin Recognition Complex in Heterochromatin by Differential DNA Affinity

Sunday, January 12 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Lower Atrium


Sunday, January 12 | 5:00PM - 7:00PM
Chromatin in Replication and Repair
Room: Jefferson

Speaker 1 of 5
* Stephen B. Baylin, Johns Hopkins University School of Medicine, USA

Sunday, January 12 | 5:00PM - 7:00PM
Chromatin in Replication and Repair
Room: Jefferson

Speaker 2 of 5
David M. Gilbert, Florida State University, USA
Early G1-Phase Establishment of Late-Replication

Sunday, January 12 | 5:00PM - 7:00PM
Chromatin in Replication and Repair
Room: Jefferson

Speaker 3 of 5
Xuetong Shen, University of Texas MD Anderson Cancer Center, USA
Involvement of INO80 ATP-Dependent Chromatin Remodeling Complex in Nuclear Functions

Sunday, January 12 | 5:00PM - 7:00PM
Chromatin in Replication and Repair
Room: Jefferson

Speaker 4 of 5
Christopher J. Ramey, University of Colorado Health Sciences Center, USA
Short Talk: Alterations to Chromatin Structure are Sufficient to Activate the DNA Damage Checkpoint

Sunday, January 12 | 5:00PM - 7:00PM
Chromatin in Replication and Repair
Room: Jefferson

Speaker 5 of 5
Leon H.F. Mullenders, Leiden University Medical Center, Netherlands
Short Talk: CHIP Analysis of Transcription Coupled Repair Complexes in UV-Irradiated Normal and NER Deficient Human Cells

Sunday, January 12 | 7:00PM - 8:00PM
Social Hour
Room: Lower Atrium/Gallatin


Sunday, January 12 | 8:00PM - 10:00PM
Poster Session 2
Room: Gallatin


Monday, January 13 | 7:00AM - 8:00AM
Breakfast
Room: Gallatin/Lake-Canyon


Monday, January 13 | 8:00AM - 11:00AM
Chromatin and Chromosomes
Room: Jefferson

Speaker 1 of 4
Jeffrey C. Hansen, Colorado State University, USA
Architectural Proteins that Convert Chromatin Fibers into Supramolecular Secondary and Tertiary Chromatin Structures

Monday, January 13 | 8:00AM - 11:00AM
Chromatin and Chromosomes
Room: Jefferson

Speaker 2 of 4
Dirk Schübeler, Friedrich Miescher Institute for Biomedical Research, Switzerland
A Genome-Wide Map of Chromatin Structure and Replication Timing Links Transcriptional Activity, DNA Replication and Histone Modifications

Monday, January 13 | 8:00AM - 11:00AM
Chromatin and Chromosomes
Room: Jefferson

Speaker 3 of 4
Susan M. Gasser, Friedrich Miescher Institute for Biomedical Research, Switzerland
Tethering and Dynamics of Chromosomes in the Nucleus

Monday, January 13 | 8:00AM - 11:00AM
Chromatin and Chromosomes
Room: Jefferson

Speaker 4 of 4
* Katherine L. Wilson, Johns Hopkins School of Medicine, USA
Chromatin Attachment to the Nuclear Envelope and emerin-Lamin Complexes

Monday, January 13 | 9:20AM - 9:40AM
Coffee Break
Room: Lower Atrium


Monday, January 13 | 11:00AM - 1:00PM
Poster Setup
Room: Gallatin


Monday, January 13 | 1:00PM - 10:00PM
Poster Viewing
Room: Gallatin


Monday, January 13 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Lower Atrium


Monday, January 13 | 5:00PM - 7:00PM
Heritable Silenced States
Room: Jefferson

Speaker 1 of 4
Andrew P. Feinberg, Johns Hopkins University School of Medicine, USA
Epigenetic Alterations in Human Cancer

Monday, January 13 | 5:00PM - 7:00PM
Heritable Silenced States
Room: Jefferson

Speaker 2 of 4
Amanda G. Fisher, Imperial College London, UK
Replication Timing as an Indicator of Lineage Restriction in Development

Monday, January 13 | 5:00PM - 7:00PM
Heritable Silenced States
Room: Jefferson

Speaker 3 of 4
* En Li, China Novartis Institutes for BioMedical Research, China
DNA Methylation in Mammalian Development and Diseases

Monday, January 13 | 5:00PM - 7:00PM
Heritable Silenced States
Room: Jefferson

Speaker 4 of 4
Zhenghan Xin, University of Virginia, USA
Short Talk: Role of G9a Histone H3 Lys9/Lys27 Methyltransferase in CpG Methylation of Imprinting Centers

Monday, January 13 | 7:00PM - 8:00PM
Social Hour
Room: Lower Atrium/Gallatin


Monday, January 13 | 8:00PM - 10:00PM
Poster Session 3
Room: Gallatin


Tuesday, January 14 | 7:00AM - 8:00AM
Breakfast
Room: Gallatin/Lake-Canyon


Tuesday, January 14 | 8:00AM - 11:00AM
Transcriptional Control During Cell Fate Decisions
Room: Jefferson

Speaker 1 of 5
Vincenzo Pirrotta, Rutgers University, USA
Polycomb Silencing Mechanisms

Tuesday, January 14 | 8:00AM - 11:00AM
Transcriptional Control During Cell Fate Decisions
Room: Jefferson

Speaker 2 of 5
Philip A. Beachy, HHMI/Stanford University, USA
Downstream Events in the Control of Cell Patterning by the Sonic Hedgehog Pathway

Tuesday, January 14 | 8:00AM - 11:00AM
Transcriptional Control During Cell Fate Decisions
Room: Jefferson

Speaker 3 of 5
* Victor G. Corces, Emory University School of Medicine, USA
Chromatin Insulators and Nuclear Organization

Tuesday, January 14 | 8:00AM - 11:00AM
Transcriptional Control During Cell Fate Decisions
Room: Jefferson

Speaker 4 of 5
Richard A. Young, Whitehead Institute for Biomedical Research, USA
Chromatin and Eukaryotic Transcriptional Regulatory Circuitry

Tuesday, January 14 | 8:00AM - 11:00AM
Transcriptional Control During Cell Fate Decisions
Room: Jefferson

Speaker 5 of 5
Victoria Lunyak, University of California, San Diego, USA
Short Talk: Corepressor-Dependent Silencing of the Chromosomal Regions Encoding Neuronal Genes

Tuesday, January 14 | 9:00AM - 12:00PM
Entertainment
Room: Jefferson/Madison


Tuesday, January 14 | 9:00AM - 12:00PM
Cash Bar
Room: Jefferson/Madison


Tuesday, January 14 | 9:20AM - 9:40AM
Coffee Break
Room: Lower Atrium


Tuesday, January 14 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Lower Atrium


Tuesday, January 14 | 5:00PM - 7:00PM
Chromatin Dysfunction and Disease
Room: Jefferson

Speaker 1 of 4
Jennifer Berger, University of Edinburgh, The King's Buildings, UK
Role of MBD2 in Gene Regulation and Tumourigenesis

Tuesday, January 14 | 5:00PM - 7:00PM
Chromatin Dysfunction and Disease
Room: Jefferson

Speaker 2 of 4
Stephen B. Baylin, Johns Hopkins University School of Medicine, USA
Gene Silencing in Cancer – Viewing the Process as a Consequence of Altered Chromatin Organization

Tuesday, January 14 | 5:00PM - 7:00PM
Chromatin Dysfunction and Disease
Room: Jefferson

Speaker 3 of 4
* Peter A. Jones, Van Andel Research Institute, USA
Reversing DNA Methylation Changes in Human Cancers

Tuesday, January 14 | 5:00PM - 7:00PM
Chromatin Dysfunction and Disease
Room: Jefferson

Speaker 4 of 4
Pier Giuseppe Pelicci, European Institute of Oncology, Italy
Epigenetic Changes Induced by Leukemia- Associated Fusion Proteins

Tuesday, January 14 | 8:00PM - 9:00PM
Social Hour
Room: Lower Atrium


Wednesday, January 15 | 10:26AM - 10:26AM
Departure


*Session Chair.