Web Desc
B Cells and Antibodies: Laboratory to Clinic
Organizer(s): Michel C. Nussenzweig, Frederick W. Alt and Louis M. Staudt
Date: January 14 - 19, 2003
Location: Keystone Resort, Keystone, CO, USA
Sponsored in part by The Director's Sponsor Fund
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Summary of Meeting:
B lymphocytes produce antibodies which are important mediators of humoral immune responses. Key advances have been made in understanding the generation of the diverse antibodies required to ?see? the antigenic world. Mechanistic insights have been gained in the areas of V(D)J recombination and it?s regulation during B cell development. In addition there has been a great deal of progress in the understanding of somatic hypermutation and switch recombination, two other somatic DNA modification reactions that contribute to antibody gene diversification. Antigen receptor assembly in developing B cells triggers a group of signaling pathways that are being defined, and many of the same pathways appear to regulate induction of tolerance and B cell responses to antigen in the periphery. New approaches to the mechanisms that establish B cell tolerance are being exploited to understand the balance between immunity and autoimmunity. Progress has also been made in using antibodies in therapeutic approaches in a number
Discounted Abstract Deadline: September 16 2002
Discounted Registration Deadline: November 14 2002
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