Web Desc
Molecular Pathology of Cardiac Arrhythmias
Organizer(s): Dan M. Roden and Andrew R. Marks
Date: January 14 - 19, 2003
Location: Hilton Santa Fe Historic Plaza Hotel, Santa Fe, NM, USA
Sponsored in part by The Director's Sponsor Fund
For important information on the coronavirus, please click here
Summary of Meeting:
Cardiac arrhythmias kill approximately 300,000 Americans each year, and a much greater number suffer disability ranging from minor symptoms to stroke. Implanted defibrillators and ablative techniques have provided benefit in some patients, but available antiarrhythmic drugs are incompletely effective and impose serious toxicity. Advances in clinical medicine and animal models that define specific arrhythmia syndromes and an increasingly sophisticated view of the molecular and genetic mechanisms that underlie them generate a realistic expectation of developing new drug strategies to impact this problem. Current drugs impair normal ion channel function; new advances identify new targets, such as channels activated in disease or signaling pathways whose activation is arrhythmogenic. The goal of this meeting will be to bring together scientists with diverse expertise in the perturbed biology that underlies arrhythmias, to develop new interdisciplinary dialogue and collaborations that will be necessary to exploit the opportunities offered by new information on arrhythmia mechanisms.
Discounted Abstract Deadline: October 30 2002
Discounted Registration Deadline: November 14 2002
We gratefully acknowledge additional support for this conference from:
American Heart Association
We gratefully acknowledge the generous grant for this conference provided by:

National Heart, Lung, and Blood Institute (NHLBI)
Grant No. 1 R13 HL071668-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, January 14 | 3:00PM - 7:00PM
Registration
Room: Promenade


Tuesday, January 14 | 6:15PM - 7:15PM
Welcome
Room: Promenade


Tuesday, January 14 | 7:15PM - 7:30PM
Orientation
Room: Mesa A


Tuesday, January 14 | 7:30PM - 8:30PM
Keynote Address
Room: Mesa A

Speaker 1 of 2
* Dan M. Roden, Vanderbilt University Medical Center, USA

Tuesday, January 14 | 7:30PM - 8:30PM
Keynote Address
Room: Mesa A

Speaker 2 of 2
David E. Clapham, Janelia Research Campus/HHMI, USA
New Classes of Calcium-Permeant Ion Channels

Wednesday, January 15 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa


Wednesday, January 15 | 8:00AM - 11:00AM
Ion Channel Structure-Function and Regulation I
Room: Mesa A

Speaker 1 of 5
* Paul B. Bennett, Merck & Co., Inc., USA

Wednesday, January 15 | 8:00AM - 11:00AM
Ion Channel Structure-Function and Regulation I
Room: Mesa A

Speaker 2 of 5
Lily Yeh Jan, University of California, San Francisco, USA
Potassium Channels

Wednesday, January 15 | 8:00AM - 11:00AM
Ion Channel Structure-Function and Regulation I
Room: Mesa A

Speaker 3 of 5
William A. Catterall, University of Washington, USA
Regulation of L-Type Voltage-Gated Calcium Channels by a Signaling Complex

Wednesday, January 15 | 8:00AM - 11:00AM
Ion Channel Structure-Function and Regulation I
Room: Mesa A

Speaker 4 of 5
Eduardo Marban, Cedars-Sinai Medical Center, USA
Gene Therapy for Cardiac Arrhythmias

Wednesday, January 15 | 8:00AM - 11:00AM
Ion Channel Structure-Function and Regulation I
Room: Mesa A

Speaker 5 of 5
Sebastian K.G. Maier, University of Wuerzburg, Germany
Short Talk: Unexpected Roles of Brain-Type Sodium Channels in Ventricular Contraction and Sino-Atrial Pacemaking

Wednesday, January 15 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Wednesday, January 15 | 11:00AM - 1:00PM
Poster Setup
Room: Mesa B


Wednesday, January 15 | 1:00PM - 10:00PM
Poster Viewing
Room: Mesa B


Wednesday, January 15 | 2:30PM - 4:30PM
Workshop: Animal Models of Cardiac Arrhythmias
Room: Mesa A

Speaker 1 of 3
Jeanne M. Nerbonne, Washington University School of Medicine, USA
Animal Models of Cardiac Arrhythmias - Is Bigger Better or Do Good Things Really Come in Small Packages?

Wednesday, January 15 | 2:30PM - 4:30PM
Workshop: Animal Models of Cardiac Arrhythmias
Room: Mesa A

Speaker 2 of 3
Penelope A. Boyden, Columbia University, USA
Models of Arrhythmias: A Discussion

Wednesday, January 15 | 2:30PM - 4:30PM
Workshop: Animal Models of Cardiac Arrhythmias
Room: Mesa A

Speaker 3 of 3
Joseph A. Hill, University of Texas Southwestern Medical Center, USA
Electrophysiological Remodeling in Cardiac Hypertrophy:
Differential Mechanisms in Compensated versus Decompensated Phenotypes


Wednesday, January 15 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Promenade


Wednesday, January 15 | 5:00PM - 7:00PM
Ion Channel Structure-Function and Regulation II
Room: Mesa A

Speaker 1 of 4
* Penelope A. Boyden, Columbia University, USA

Wednesday, January 15 | 5:00PM - 7:00PM
Ion Channel Structure-Function and Regulation II
Room: Mesa A

Speaker 2 of 4
Robert S. Kass, Columbia University, USA
Ion Channel Mutations and Inherited Arrhythmias: Inherited Mutations Uncouple IKs Channels from Regulation by the Sympathetic Nervous System (SNS)

Wednesday, January 15 | 5:00PM - 7:00PM
Ion Channel Structure-Function and Regulation II
Room: Mesa A

Speaker 3 of 4
Barbara E. Ehrlich, Yale University, USA
Modulation of the Inositol-1,4,5-Triphosphate Receptor (InsP3R)

Wednesday, January 15 | 5:00PM - 7:00PM
Ion Channel Structure-Function and Regulation II
Room: Mesa A

Speaker 4 of 4
Christian Ramakers, Cardiovascular Research Institute Maastricht, Netherlands
Short Talk: Downregulation of KCNQ1 and KCNE1 Contributes to Reduction of IKs in Canine Hypertrophied Hearts

Wednesday, January 15 | 7:00PM - 8:00PM
Social Hour
Room: Mesa B


Wednesday, January 15 | 8:00PM - 10:00PM
Poster Session 1: Arrhythmia Models
Room: Mesa B


Thursday, January 16 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa


Thursday, January 16 | 8:00AM - 11:00AM
Genetics of Cardiac Arrhythmias I
Room: Mesa A

Speaker 1 of 5
* Andrew R. Marks, Columbia University College of Physicians and Surgeons, USA

Thursday, January 16 | 8:00AM - 11:00AM
Genetics of Cardiac Arrhythmias I
Room: Mesa A

Speaker 2 of 5
Christine E. Seidman, Harvard Medical School, USA
PRKAG2 Mutations: Molecular Insights into Cardiac Hypertrophy, Ventricular Preexcitation and Conduction System Disease

Thursday, January 16 | 8:00AM - 11:00AM
Genetics of Cardiac Arrhythmias I
Room: Mesa A

Speaker 3 of 5
Mark T. Keating, Novartis Institutes for BioMedical Research, USA
Variant of SCN5A Sodium Channel Implicated in Risk of Cardiac Arrhythmia


Thursday, January 16 | 8:00AM - 11:00AM
Genetics of Cardiac Arrhythmias I
Room: Mesa A

Speaker 4 of 5
Jeffrey R. Balser, Vanderbilt University School of Medicine, USA
Inherited Disease of the Sodium Channel: Insights into Calcium Signaling and Function

Thursday, January 16 | 8:00AM - 11:00AM
Genetics of Cardiac Arrhythmias I
Room: Mesa A

Speaker 5 of 5
Denis Escande, University of Nantes, France
Short Talk: Ankyrin-B Mutation Causes Type 4 Long QT Syndrome

Thursday, January 16 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Thursday, January 16 | 11:00AM - 1:00PM
Poster Setup
Room: Mesa B


Thursday, January 16 | 1:00PM - 10:00PM
Poster Viewing
Room: Mesa B


Thursday, January 16 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Promenade


Thursday, January 16 | 5:00PM - 7:00PM
From Molecule to Whole Heart
Room: Mesa A

Speaker 1 of 4
Dan M. Roden, Vanderbilt University Medical Center, USA
Human Genomics and its Impact on Arrhythmia Presentation and Therapy

Thursday, January 16 | 5:00PM - 7:00PM
From Molecule to Whole Heart
Room: Mesa A

Speaker 2 of 4
Michael C. Sanguinetti, University of Utah, USA
Molecular Mechanisms of Drug-Induced Long QT Syndrome

Thursday, January 16 | 5:00PM - 7:00PM
From Molecule to Whole Heart
Room: Mesa A

Speaker 3 of 4
James N. Weiss, University of California, Los Angeles, USA
A Novel Approach to Identifying Antiarrhythmic Drug Targets

Thursday, January 16 | 5:00PM - 7:00PM
From Molecule to Whole Heart
Room: Mesa A

Speaker 4 of 4
Dou Zhang, Baylor College of Medicine, USA
Short Talk: Conditional Inhibition of TAK1 (MAP3K7) Provokes Wolff Parkinson-White Syndrome and Early-Onset Heart Failure in Mice

Thursday, January 16 | 7:00PM - 8:00PM
Social Hour
Room: Mesa B


Thursday, January 16 | 8:00PM - 10:00PM
Poster Session 2: Molecular Genetics of Arrhythmias
Room: Mesa B


Friday, January 17 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa


Friday, January 17 | 8:00AM - 11:00AM
Calcium and Cardiac Arrhythmogenesis
Room: Mesa A

Speaker 1 of 6
* Mark E. Anderson, Johns Hopkins University School of Medicine, USA

Friday, January 17 | 8:00AM - 11:00AM
Calcium and Cardiac Arrhythmogenesis
Room: Mesa A

Speaker 2 of 6
Martin D. Bootman, Babraham Institute, UK
Inositol 1,4,5-Trisphosphate Receptors in Cardiac Myocytes - Where are They and What Do They Do?

Friday, January 17 | 8:00AM - 11:00AM
Calcium and Cardiac Arrhythmogenesis
Room: Mesa A

Speaker 3 of 6
Andrew R. Marks, Columbia University College of Physicians and Surgeons, USA
Macromolecular Complexes: Regulation of Ryanodine Receptors by Phosphorylation

Friday, January 17 | 8:00AM - 11:00AM
Calcium and Cardiac Arrhythmogenesis
Room: Mesa A

Speaker 4 of 6
W. Jonathan Lederer, University of Maryland Baltimore, USA
Local Calcium Signaling in Heart

Friday, January 17 | 8:00AM - 11:00AM
Calcium and Cardiac Arrhythmogenesis
Room: Mesa A

Speaker 5 of 6
Susan L. Hamilton, Baylor College of Medicine, USA
Regulation of RyR1 and RyR2 by Calmodulin and FKBP12

Friday, January 17 | 8:00AM - 11:00AM
Calcium and Cardiac Arrhythmogenesis
Room: Mesa A

Speaker 6 of 6
† Samuel C. Dudley, University of Minnesota, USA
Short Talk: Disordered Sarcoplasmic Reticulum Ca2+ Release May Contribute to Arrhythmic Risk in Heart Failure

Friday, January 17 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Friday, January 17 | 11:00AM - 1:00PM
Poster Setup
Room: Mesa B


Friday, January 17 | 1:00PM - 10:00PM
Poster Viewing
Room: Mesa B


Friday, January 17 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Promenade


Friday, January 17 | 5:00PM - 7:00PM
Physiological Triggers for Cardiac Arrhythmias
Room: Mesa A

Speaker 1 of 4
* Susan L. Hamilton, Baylor College of Medicine, USA

Friday, January 17 | 5:00PM - 7:00PM
Physiological Triggers for Cardiac Arrhythmias
Room: Mesa A

Speaker 2 of 4
Jeffrey E. Saffitz, Beth Israel Deaconess Medical Center, USA
Molecular Defects in Intercellular Junctions in Cardiac Arrhythmogenesis

Friday, January 17 | 5:00PM - 7:00PM
Physiological Triggers for Cardiac Arrhythmias
Room: Mesa A

Speaker 3 of 4
Donald M. Bers, University of California, Davis, USA
Cellular Basis of Triggered Arrhythmias in Heart Failure

Friday, January 17 | 5:00PM - 7:00PM
Physiological Triggers for Cardiac Arrhythmias
Room: Mesa A

Speaker 4 of 4
Heather S. Duffy, Beth Israel Deaconess Medical Center, USA
Short Talk: Biochemical and Structural Analysis of the pH-Dependent Closure of Connexin43

Friday, January 17 | 7:00PM - 8:00PM
Social Hour
Room: Mesa B


Friday, January 17 | 8:00PM - 10:00PM
Poster Session 3: Ion Channel Function
Room: Mesa B


Saturday, January 18 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa


Saturday, January 18 | 8:00AM - 11:00AM
Ion Channel Assembly and Modulation
Room: Mesa A

Speaker 1 of 6
* William A. Catterall, University of Washington, USA

Saturday, January 18 | 8:00AM - 11:00AM
Ion Channel Assembly and Modulation
Room: Mesa A

Speaker 2 of 6
Franz Hofmann, Technische Universität München, Germany
Pacemaker Channels and Sinus Node Arrhythmia

Saturday, January 18 | 8:00AM - 11:00AM
Ion Channel Assembly and Modulation
Room: Mesa A

Speaker 3 of 6
Michael M. Tamkun, Colorado State University, USA
Ion Channel Targeting to Lipid Raft Domains

Saturday, January 18 | 8:00AM - 11:00AM
Ion Channel Assembly and Modulation
Room: Mesa A

Speaker 4 of 6
Mark E. Anderson, Johns Hopkins University School of Medicine, USA
CaM Kinase and L-Type Ca2+ Channels: A Recipe for Arrhythmias?

Saturday, January 18 | 8:00AM - 11:00AM
Ion Channel Assembly and Modulation
Room: Mesa A

Speaker 5 of 6
Diomedes E. Logothetis, Mount Sinai School of Medicine, USA
Gating of a Potassium Channel by the betagamma Subunits of G Proteins

Saturday, January 18 | 8:00AM - 11:00AM
Ion Channel Assembly and Modulation
Room: Mesa A

Speaker 6 of 6
David R. Van Wagoner, Cleveland Clinic Foundation, USA
Short Talk: Inflammation and Pacing Promote Atrial Fibrillation via Distinct Mechanisms

Saturday, January 18 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Saturday, January 18 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Promenade


Saturday, January 18 | 5:00PM - 7:00PM
High Throughput Screening and Identification of Novel Therap
eutic Targets

Room: Mesa A

Speaker 1 of 3
* Robert S. Kass, Columbia University, USA

Saturday, January 18 | 5:00PM - 7:00PM
High Throughput Screening and Identification of Novel Therap
eutic Targets

Room: Mesa A

Speaker 2 of 3
Paul B. Bennett, Merck & Co., Inc., USA
Critical Issues in the Development of Ion Channels as Drug Targets

Saturday, January 18 | 5:00PM - 7:00PM
High Throughput Screening and Identification of Novel Therap
eutic Targets

Room: Mesa A

Speaker 3 of 3
Morten Grunnet, University of Copenhagen, Denmark
Short Talk: KCNQ1 Channels: Sensors of Cell Volume Changes

Saturday, January 18 | 7:00PM - 8:00PM
Social Hour
Room: Mesa B


Saturday, January 18 | 8:00PM - 11:00PM
Entertainment
Room: Mesa B


Saturday, January 18 | 8:00PM - 11:00PM
Cash Bar
Room: Mesa B


Sunday, January 19 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.