Web Desc
Drug Target Validation: Gene Suppression
Organizer(s): Peter B. Dervan, Stephen W. Fesik and Michael Briggs
Date: January 17 - 22, 2003
Location: Granlibakken Tahoe, Tahoe City, CA, USA
Sponsored by Abbott Laboratories
For important information on the coronavirus, please click here
Summary of Meeting:
There is an enormous interest in the application of diverse chemical and biological tools to control the expression of specific genes or compromise the activities of specific mRNAs and proteins. The biotechnology industry develops these tools for plant and animal engineering, the pharmaceutical industry makes use of these tools to validate drug targets, and the medical community investigates a subset of these reagents as therapeutics in their own right. The purpose of this Keystone Symposium is to review the utility of chemical and biological approaches to selectively turning gene activity off at the transcriptional, post-transcriptional and protein level- especially with reference to functional genomics. The aim is to provide a broad overview of established and emerging methodologies, the basic science behind these approaches and their utility from an industrial and medical perspective. The availability of the human genome and widespread use of micro array strategies for assessing specificity should make the meeting especially timely and provide a unifying focus by 2003. The latest advances on RNA interference, protein engineering to repress transcription, chemical approaches to gene control, antisense, ribozymes and knockout strategies will be discussed.
Discounted Abstract Deadline: September 17 2002
Discounted Registration Deadline: November 18 2002
We gratefully acknowledge additional support for this conference from:

Abbott Laboratories
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of General Medical Sciences (NIGMS)
Grant No. 1 R13 GM067309-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Friday, January 17 | 3:00PM - 7:00PM
Registration
Room: Pre-Function


Friday, January 17 | 7:15PM - 7:30PM
Orientation
Room: Mountain/Lake Rooms


Friday, January 17 | 7:30PM - 8:30PM
Keynote Address
Room: Mountain/Lake Rooms

Speaker 1 of 1
Robert G. Roeder, Rockefeller University, USA
Regulation of Eukaryotic Transcription through Diverse and Complex Transcription Machineries

Saturday, January 18 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Saturday, January 18 | 8:00AM - 11:00AM
RNA Interference
Room: Mountain/Lake Rooms

Speaker 1 of 4
* Thomas Tuschl, HHMI/Rockefeller University, USA
Analysis of Mammalian Gene Function Using Small Interfering RNAs

Saturday, January 18 | 8:00AM - 11:00AM
RNA Interference
Room: Mountain/Lake Rooms

Speaker 2 of 4
Christophe J. Echeverri, Cenix BioScience GmbH, Germany
Exploring the Full Potential of RNAi: From Integrated Target Discovery and Validation to a New Class of Therapeutics

Saturday, January 18 | 8:00AM - 11:00AM
RNA Interference
Room: Mountain/Lake Rooms

Speaker 3 of 4
Helmuth H. van Es, ModiQuest B.V., Netherlands
Target Discovery and Validation Using Arrayed Knock-in and Knock-down Adenoviral Libraries

Saturday, January 18 | 8:00AM - 11:00AM
RNA Interference
Room: Mountain/Lake Rooms

Speaker 4 of 4
René Bernards, Netherlands Cancer Institute, Netherlands
Genome-Wide Loss-of-Function Phenotypic Screens in Mammalian Cells

Saturday, January 18 | 9:20AM - 9:40AM
Coffee Break
Room: Pre-Function


Saturday, January 18 | 11:00AM - 1:00PM
Poster Setup
Room: Bay Room


Saturday, January 18 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay Room


Saturday, January 18 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Pre-Function


Saturday, January 18 | 5:00PM - 7:00PM
Protein Engineering to Repress Transcription
Room: Mountain/Lake Rooms

Speaker 1 of 3
* Carl O. Pabo, Sangamo Therapeutics, Inc., USA
Regulation of Endogenous Gene Expression with Engineered C2H2 Zinc Finger Transcription Factors

Saturday, January 18 | 5:00PM - 7:00PM
Protein Engineering to Repress Transcription
Room: Mountain/Lake Rooms

Speaker 2 of 3
J. Keith Joung, Massachusetts General Hospital, USA
Engineered Zinc Finger Proteins for Transcription Regulation

Saturday, January 18 | 5:00PM - 7:00PM
Protein Engineering to Repress Transcription
Room: Mountain/Lake Rooms

Speaker 3 of 3
Carlos F. Barbas III, The Scripps Research Institute, USA
Endogenous Gene Regulation with Polydactyl Zinc Finger Transcription Factors

Saturday, January 18 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Saturday, January 18 | 8:00PM - 10:00PM
Poster Session 1
Room: Bay Room


Saturday, January 18 | 8:00PM - 9:00PM
Social Hour
Room: Bay Room


Sunday, January 19 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Sunday, January 19 | 8:00AM - 11:00AM
Chemical Approaches to Transcriptional Control
Room: Mountain/Lake Rooms

Speaker 1 of 4
* Joel M. Gottesfeld, The Scripps Research Institute, USA
Regulation of Gene Expression by Polyamides

Sunday, January 19 | 8:00AM - 11:00AM
Chemical Approaches to Transcriptional Control
Room: Mountain/Lake Rooms

Speaker 2 of 4
Karolin Luger, University of Colorado Boulder, USA
Small DNA Binding Ligands to Study Structure and Dynamics of Chromatin

Sunday, January 19 | 8:00AM - 11:00AM
Chemical Approaches to Transcriptional Control
Room: Mountain/Lake Rooms

Speaker 3 of 4
Aseem Z. Ansari, University of Wisconsin-Madison, USA
Modular Design of Artificial Transcription Factors

Sunday, January 19 | 8:00AM - 11:00AM
Chemical Approaches to Transcriptional Control
Room: Mountain/Lake Rooms

Speaker 4 of 4
David M. Margolis, University of North Carolina at Chapel Hill, USA
Polyamides induce Derepression of HIV within Primary Resting T Cells

Sunday, January 19 | 9:20AM - 9:40AM
Coffee Break
Room: Pre-Function


Sunday, January 19 | 11:00AM - 1:00PM
Poster Setup
Room: Bay Room


Sunday, January 19 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay Room


Sunday, January 19 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Pre-Function


Sunday, January 19 | 5:00PM - 7:00PM
Antigene
Room: Mountain/Lake Rooms

Speaker 1 of 3
* Carine Giovannangeli, Muséum National d'Histoire Naturelle, France
Sequence-Specific Control of Gene Transcription by Antigene Oligonucleotides

Sunday, January 19 | 5:00PM - 7:00PM
Antigene
Room: Mountain/Lake Rooms

Speaker 2 of 3
Peter E. Nielsen, University of Copenhagen, Denmark
Targeting Duplex DNA by Peptide Nucleic Acids

Sunday, January 19 | 5:00PM - 7:00PM
Antigene
Room: Mountain/Lake Rooms

Speaker 3 of 3
David R. Corey, University of Texas Southwestern Medical Center, USA
Strand Invasion by Peptide Nucleic Acids

Sunday, January 19 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Sunday, January 19 | 8:00PM - 10:00PM
Poster Session 2
Room: Bay Room


Sunday, January 19 | 8:00PM - 9:00PM
Social Hour
Room: Bay Room


Monday, January 20 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Monday, January 20 | 8:00AM - 11:00AM
siRNA/Antisense
Room: Mountain/Lake Rooms

Speaker 1 of 5
Michael R. Briggs, Vertex Pharmaceuticals Incorporated, USA

Monday, January 20 | 8:00AM - 11:00AM
siRNA/Antisense
Room: Mountain/Lake Rooms

Speaker 2 of 5
Stephen W. Fesik, Vanderbilt University School of Medicine, USA
Target Identification/Validation using siRNA

Monday, January 20 | 8:00AM - 11:00AM
siRNA/Antisense
Room: Mountain/Lake Rooms

Speaker 3 of 5
Jonathan W. Nyce, Epigenesis Pharmaceuticals, Inc., USA
Respirable Antisense Oligonucleotides (RANs) as Therapeutics and Tools for Respiratory Target Evaluation

Monday, January 20 | 8:00AM - 11:00AM
siRNA/Antisense
Room: Mountain/Lake Rooms

Speaker 4 of 5
Nicholas M. Dean, Providence Therapeutics, Canada
Functional Genomics Applications of Antisense



Monday, January 20 | 8:00AM - 11:00AM
siRNA/Antisense
Room: Mountain/Lake Rooms

Speaker 5 of 5
David L. Lewis, Arrowhead Research Corporation, USA
Short Talk

Monday, January 20 | 9:20AM - 9:40AM
Coffee Break
Room: Pre-Function


Monday, January 20 | 11:00AM - 1:00PM
Poster Setup
Room: Bay Room


Monday, January 20 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay Room


Monday, January 20 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Pre-Function


Monday, January 20 | 5:00PM - 7:00PM
Chemical Approaches to Gene Control
Room: Mountain/Lake Rooms

Speaker 1 of 3
* Laurence H. Hurley, Arizona Cancer Center, USA
Transcription Control by Ligand-Mediated G-Quadruplex Stabilization

Monday, January 20 | 5:00PM - 7:00PM
Chemical Approaches to Gene Control
Room: Mountain/Lake Rooms

Speaker 2 of 3
James E. Summerton, Gene Tools, LLC, USA
Morpholino Antisense Oligos: Efficient and Reliable Tools for Validating Drug Targets

Monday, January 20 | 5:00PM - 7:00PM
Chemical Approaches to Gene Control
Room: Mountain/Lake Rooms

Speaker 3 of 3
Vikram Arora, AVI BioPharma, Inc., USA
Inhibition of Gene Expression in the Liver Following Oral Administration of Morpholino Oligomers

Monday, January 20 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Monday, January 20 | 8:00PM - 10:00PM
Poster Session 3
Room: Bay Room


Monday, January 20 | 8:00PM - 9:00PM
Social Hour
Room: Bay Room


Tuesday, January 21 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Tuesday, January 21 | 8:00AM - 11:00AM
Knockout
Room: Mountain/Lake Rooms

Speaker 1 of 4
* Bill Matthews, Deltagen, USA
Creating a Research Infrastructure for Systems Biology Using High Throughput Gene Knockouts

Tuesday, January 21 | 8:00AM - 11:00AM
Knockout
Room: Mountain/Lake Rooms

Speaker 2 of 4
Pengbo Zhou, Weill Cornell Medical College, USA
Targeted Protein Degradation

Tuesday, January 21 | 8:00AM - 11:00AM
Knockout
Room: Mountain/Lake Rooms

Speaker 3 of 4
Brian Zambrowicz, Regeneron, USA
The Value of Mouse Genetics for Drug Discovery

Tuesday, January 21 | 8:00AM - 11:00AM
Knockout
Room: Mountain/Lake Rooms

Speaker 4 of 4
Andras Nagy, Mount Sinai Hospital, University of Toronto, Canada
Mutagenesis in ES Cells and Mice

Tuesday, January 21 | 9:00AM - 12:00PM
Entertainment
Room: Mountain/Lake Rooms


Tuesday, January 21 | 9:00AM - 12:00PM
Cash Bar
Room: Mountain/Lake Rooms


Tuesday, January 21 | 9:20AM - 9:40AM
Coffee Break
Room: Pre-Function


Tuesday, January 21 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Pre-Function


Tuesday, January 21 | 5:00PM - 7:00PM
Ribozymes
Room: Mountain/Lake Rooms

Speaker 1 of 3
* Flossie Wong-Staal, ItherX Pharmaceuticals Inc., USA
Ribozymes and Inverse Genomics for Functional Gene Dicovery

Tuesday, January 21 | 5:00PM - 7:00PM
Ribozymes
Room: Mountain/Lake Rooms

Speaker 2 of 3
David V. Morrissey, Triplet Therapeutics, Inc., USA
Ribozyme and siRNA Therapies for Viral Hepatitis

Tuesday, January 21 | 5:00PM - 7:00PM
Ribozymes
Room: Mountain/Lake Rooms

Speaker 3 of 3
John J. Rossi, Beckman Research Institute of the City of Hope, USA
Combinatorial Ribozyme, Decoy and siRNA Therapies for HIV-1

Tuesday, January 21 | 7:00PM - 8:00PM
Social Hour
Room: Granhall


Tuesday, January 21 | 8:00PM - 9:00PM
Dinner
Room: Mountain/Lake Rooms


Wednesday, January 22 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.