Web Desc
Tuberculosis: Integrating Host and Pathogen Biology
Organizer(s): Gilla Kaplan, Clifton E. Barry III and Stewart Cole
Date: January 25 - 30, 2003
Location: Sagebrush Inn & Suites, Taos, NM, USA
Supported by Keystone Symposia
Summary of Meeting:
With the completion of the genome sequence for both Mycobacterium tuberculosis and Homo sapiens the complexities of pathogen host interaction are now accessible for study. The aims of this meeting are: to review the latest insights obtained from analysis of the genome sequence of M. tuberculosis; to dissect the cell biology of the interaction between M. tuberculosis and host cells; to understand the physiology of the pathogen and identify novel targets for drug development; to discuss the molecular basis of M. tuberculosis strain differences and the implications for transmission and immunity; to explore mechanisms of pathogenesis; to learn how the host develops protective immunity against the pathogen; and to develop strategies for manipulation of the host response to tuberculosis through vaccine development. The stimulating discussion among epidemiologists, cell biologists, immunologists, microbial geneticists, and biotechnologists will define the direction of research and accelerate the development of new therapies, diagnostics, and vaccines and promote the forging of new collaborative efforts.
We gratefully acknowledge additional support for this conference from:
AstraZeneca R&D
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1 R13 AI053720-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Saturday, January 25 | 3:00PM - 7:00PM
Registration
Room: Chamisa Lobby


Saturday, January 25 | 6:15PM - 7:15PM
Welcome
Room: Chamisa Lobby


Saturday, January 25 | 7:15PM - 7:30PM
Orientation
Room: Chamisa 1


Saturday, January 25 | 7:30PM - 8:30PM
Opening Remarks
Room: Chamisa 1

Speaker 1 of 1
Clifton E. Barry III, NIAID, National Institutes of Health, USA
Opening Remarks

Sunday, January 26 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Sunday, January 26 | 8:00AM - 11:00AM
Exploratory Genomics - Prokaryotic (Genomes, Proteomes, Stru
ctural Genomics)

Room: Chamisa 1

Speaker 1 of 4
* Stewart T. Cole, Institut Pasteur, France
Evolutionary and Comparative Genomics of the M. tuberculosis Complex

Sunday, January 26 | 8:00AM - 11:00AM
Exploratory Genomics - Prokaryotic (Genomes, Proteomes, Stru
ctural Genomics)

Room: Chamisa 1

Speaker 2 of 4
William R. Jacobs, Jr., HHMI/Albert Einstein College of Medicine, USA
Unmasking the Intracellular Lifestyles of Mycobacterium tuberculosis

Sunday, January 26 | 8:00AM - 11:00AM
Exploratory Genomics - Prokaryotic (Genomes, Proteomes, Stru
ctural Genomics)

Room: Chamisa 1

Speaker 3 of 4
John T. Belisle, Colorado State University, USA
Proteomics for the Study of Tuberculosis

Sunday, January 26 | 8:00AM - 11:00AM
Exploratory Genomics - Prokaryotic (Genomes, Proteomes, Stru
ctural Genomics)

Room: Chamisa 1

Speaker 4 of 4
Peter M. Small, Bill & Melinda Gates Foundation, USA
Comparing Genomes within the Species M. tuberculosis

Sunday, January 26 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa 2


Sunday, January 26 | 11:00AM - 1:00PM
Poster Setup
Room: Chamisa 2


Sunday, January 26 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa 2


Sunday, January 26 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Chamisa 2


Sunday, January 26 | 5:00PM - 7:00PM
Mycobacterial Lipids and Lipid Metabolism in TB Pathogenesis
Room: Chamisa 1

Speaker 1 of 3
* Clifton E. Barry III, NIAID, National Institutes of Health, USA
The Role of Polyketides in MTB Virulence

Sunday, January 26 | 5:00PM - 7:00PM
Mycobacterial Lipids and Lipid Metabolism in TB Pathogenesis
Room: Chamisa 1

Speaker 2 of 3
Helen Billman-Jacobe, University of Melbourne, Australia
Glycopeptidolipid Biosynthesis in Mycobacteria

Sunday, January 26 | 5:00PM - 7:00PM
Mycobacterial Lipids and Lipid Metabolism in TB Pathogenesis
Room: Chamisa 1

Speaker 3 of 3
Gilla Kaplan, University of Cape Town, South Africa
The Role of MTB Lipids in Immunity and Virulence of Clinical Isolates

Sunday, January 26 | 7:00PM - 8:00PM
Social Hour
Room: Los Vaqueros


Sunday, January 26 | 8:00PM - 10:00PM
Poster Session 1: Bacterial Physiology and Genomics
Room: Chamisa 2


Monday, January 27 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Monday, January 27 | 8:00AM - 11:00AM
Regulation and Genetics. Session Sponsored by The Ellison M
edical Foundation.

Room: Chamisa 1

Speaker 1 of 4
James C. Sacchettini, Texas A & M University, USA
The Structural Genomics Consortium

Monday, January 27 | 8:00AM - 11:00AM
Regulation and Genetics. Session Sponsored by The Ellison M
edical Foundation.

Room: Chamisa 1

Speaker 2 of 4
Harvey Rubin, University of Pennsylvania School of Medicine, USA
Regulatory Enzymes in MTB

Monday, January 27 | 8:00AM - 11:00AM
Regulation and Genetics. Session Sponsored by The Ellison M
edical Foundation.

Room: Chamisa 1

Speaker 3 of 4
* William R. Bishai, Johns Hopkins School of Medicine and K-RITH, USA
Sigma Factors and Regulation of Gene Expression in M. tuberculosis

Monday, January 27 | 8:00AM - 11:00AM
Regulation and Genetics. Session Sponsored by The Ellison M
edical Foundation.

Room: Chamisa 1

Speaker 4 of 4
Neil G. Stoker, Royal Veterinary College, UK
Two-Component Systems

Monday, January 27 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa 2


Monday, January 27 | 11:00AM - 1:00PM
Poster Setup
Room: Chamisa 2


Monday, January 27 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa 2


Monday, January 27 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Chamisa 2


Monday, January 27 | 5:00PM - 7:00PM
Adaptation of the Host and Pathogen to Coexistance
Room: Chamisa 1

Speaker 1 of 3
Maria Laura Gennaro, Public Health Research Institute (PHRI), USA
Antigen Specificity of the Host Immune Response and Pathogen Biology

Monday, January 27 | 5:00PM - 7:00PM
Adaptation of the Host and Pathogen to Coexistance
Room: Chamisa 1

Speaker 2 of 3
John D. McKinney, Swiss Federal Institute of Technology (EPFL), Switzerland
MTB Persistence

Monday, January 27 | 5:00PM - 7:00PM
Adaptation of the Host and Pathogen to Coexistance
Room: Chamisa 1

Speaker 3 of 3
* Douglas B. Young, Imperial College London, UK
Pathogen Adaptations to the Host Immune Response

Monday, January 27 | 7:00PM - 8:00PM
Social Hour
Room: Los Vaqueros


Monday, January 27 | 8:00PM - 10:00PM
Poster Session 2: Pathogenesis and Virulence
Room: Chamisa 2


Tuesday, January 28 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Tuesday, January 28 | 8:00AM - 11:00AM
Macrophage MTB Interaction
Room: Chamisa 1

Speaker 1 of 4
* David G. Russell, Cornell University, USA
Mycobacterium tuberculosis: The Indigestible Microbe

Tuesday, January 28 | 8:00AM - 11:00AM
Macrophage MTB Interaction
Room: Chamisa 1

Speaker 2 of 4
Jean Pieters, University of Basel, Switzerland
Evasion of Host Cell Defense Mechanisms by Pathogenic Mycobacteria

Tuesday, January 28 | 8:00AM - 11:00AM
Macrophage MTB Interaction
Room: Chamisa 1

Speaker 3 of 4
Carl F. Nathan, Weill Cornell Medical College, USA
Targeting Defenses of M. tuberculosis Against Reactive Nitrogen Intermediates (RNI)

Tuesday, January 28 | 8:00AM - 11:00AM
Macrophage MTB Interaction
Room: Chamisa 1

Speaker 4 of 4
Alan Aderem, Center for Infectious Disease Research, USA
The Role of Toll-Like Receptors in Orchestrating the Innate Immune Response

Tuesday, January 28 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa 2


Tuesday, January 28 | 11:00AM - 1:00PM
Poster Setup
Room: Chamisa 2


Tuesday, January 28 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa 2


Tuesday, January 28 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Chamisa 2


Tuesday, January 28 | 5:00PM - 7:00PM
Immune Responses and Vaccine Development
Room: Chamisa 1

Speaker 1 of 3
Robert A. Seder, NIAID, National Institutes of Health, USA
Vaccine Strategies to Induce Sustained Cellular Immune Responses in vivo Against Intracellular Infections

Tuesday, January 28 | 5:00PM - 7:00PM
Immune Responses and Vaccine Development
Room: Chamisa 1

Speaker 2 of 3
* Peter L. Andersen, Statens Serum Institut, Denmark
Tuberculosis Subunit Vaccines – Recent Progress Based on Proteomics, Genomics and Studies in Animal Models

Tuesday, January 28 | 5:00PM - 7:00PM
Immune Responses and Vaccine Development
Room: Chamisa 1

Speaker 3 of 3
M. Joseph Colston, Medical Research Council, UK
Dendritic Cells and Their Role in Priming Immune Responses to Mycobacteria

Tuesday, January 28 | 7:00PM - 8:00PM
Social Hour
Room: Los Vaqueros


Tuesday, January 28 | 8:00PM - 10:00PM
Poster Session 3: Immunology and Vaccines
Room: Chamisa 2


Wednesday, January 29 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Wednesday, January 29 | 8:00AM - 11:00AM
Host Immune Responses to MTB Infection
Room: Chamisa 1

Speaker 1 of 4
Jan A.M. Langermans, Biomedical Primate Research Centre, Netherlands
The Immune Response to Tuberculosis: Non-Human Primate Models

Wednesday, January 29 | 8:00AM - 11:00AM
Host Immune Responses to MTB Infection
Room: Chamisa 1

Speaker 2 of 4
Warwick J. Britton, Centenary Institute, Australia
Regulation of the Granulomatous Response to Mycobacterium tuberculosis

Wednesday, January 29 | 8:00AM - 11:00AM
Host Immune Responses to MTB Infection
Room: Chamisa 1

Speaker 3 of 4
Anne E. Goldfeld, Children's Hospital Boston, Harvard Medical School, USA
Variations in Host Immune Response to TB Infection

Wednesday, January 29 | 8:00AM - 11:00AM
Host Immune Responses to MTB Infection
Room: Chamisa 1

Speaker 4 of 4
* Stefan H. E. Kaufmann, Max Planck Institute for Infection Biology, Berlin, Germany
The T Cell Response to Mycobacterium tuberculosis

Wednesday, January 29 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa 2


Wednesday, January 29 | 11:00AM - 11:30AM
Poster Setup


Wednesday, January 29 | 11:30AM - 12:30PM
Lunch
Room: Los Vaqueros


Wednesday, January 29 | 12:30PM - 2:30PM
Poster Session 4: Diagnostics, Therapeutics and Vaccines


Wednesday, January 29 | 3:30PM - 4:00PM
Coffee & Snacks Available
Room: Chamisa 2


Wednesday, January 29 | 4:00PM - 6:00PM
Exploratory Genomics - Eukaryotic (The Host Genomics, Proteo
mics, Genetics)

Room: Chamisa 1

Speaker 1 of 3
* Alan Sher, NIAID, National Institutes of Health, USA
A Novel Gene Family which Controls Acute Host Resistance to Mycobacteria and Other Intracellular Pathogens

Wednesday, January 29 | 4:00PM - 6:00PM
Exploratory Genomics - Eukaryotic (The Host Genomics, Proteo
mics, Genetics)

Room: Chamisa 1

Speaker 2 of 3
Jean-Laurent Casanova, Rockefeller University, USA
Genetic Dissection of Immunity to Mycobacteria: The Human Model

Wednesday, January 29 | 4:00PM - 6:00PM
Exploratory Genomics - Eukaryotic (The Host Genomics, Proteo
mics, Genetics)

Room: Chamisa 1

Speaker 3 of 3
Richard A. Young, Whitehead Institute for Biomedical Research, USA
Exploring the Host Response to Pathogens Using Microarray Technologies

Wednesday, January 29 | 7:00PM - 8:00PM
Social Hour
Room: Chamisa 2


Wednesday, January 29 | 8:00PM - 11:00PM
Entertainment
Room: Chamisa 2


Wednesday, January 29 | 8:00PM - 11:00PM
Cash Bar
Room: Chamisa 2


Thursday, January 30 | 10:26AM - 10:26AM
Departure


*Session Chair.