Web Desc
PPARs: Transcriptional Regulators of Metabolism and Metabolic Disease
Organizer(s): Ronald M. Evans, Bruce M. Spiegelman and Christopher K. Glass
Date: February 04 - 09, 2003
Location: Keystone Resort, Keystone, CO, USA
Sponsored by Pfizer Global Research and Development
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Summary of Meeting:
· To review recent findings that focus attention on PPARs as key targets in the pathogenicity of obesity, diabetes, atherosclerosis and cancer. Also, genetic alterations in PPARs in humans with diabetes/lipodystrophy syndrome and cancer. · To describe insights from new animal models and clinical studies that relate to an emerging biology of lipid metabolism and inflammation and disease. · To identify the transcriptional basis of these phenomena by the identification of PPAR target genes. · To dissect the mechanism(s) by which PPAR active drugs modulate cancer, affect heart disease, and function as anti-diabetic compounds. · To explore the recent links between the action of the PPARs with other nuclear receptors such as LXR and implications for cholesterol metabolism. · To foster new insights that will lead to novel and effective insights to the origin and treatment of PPAR related disease. · To develop new collaborations among the scientists in attendance.
Discounted Abstract Deadline: October 3 2002
Discounted Registration Deadline: December 4 2002
We gratefully acknowledge additional support for this conference from:

Affinity BioReagents, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 1 R13 DK063898-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, February 04 | 3:00PM - 7:00PM
Registration
Room: Longs Peak Foyer


Tuesday, February 04 | 6:15PM - 7:15PM
Welcome
Room: Longs Peak Foyer


Tuesday, February 04 | 7:15PM - 7:30PM
Orientation
Room: Grays Peak 1-2


Tuesday, February 04 | 7:30PM - 8:30PM
Keynote Address
Room: Grays Peak 1-2

Speaker 1 of 1
Jeffrey M. Friedman, Rockefeller University, USA

Wednesday, February 05 | 7:00AM - 8:00AM
Breakfast
Room: Longs Peak


Wednesday, February 05 | 8:00AM - 11:00AM
Molecular Mechanisms
Room: Grays Peak 1-2

Speaker 1 of 4
Christopher K. Glass, University of California, San Diego, USA
Roles of PPARgamma in Macrophage Biology and Atherosclerosis

Wednesday, February 05 | 8:00AM - 11:00AM
Molecular Mechanisms
Room: Grays Peak 1-2

Speaker 2 of 4
Johan Auwerx, École Polytechnique Fédérale de Lausanne, Switzerland
PPARgamma and its Coregulators in the Control of Metabolism

Wednesday, February 05 | 8:00AM - 11:00AM
Molecular Mechanisms
Room: Grays Peak 1-2

Speaker 3 of 4
Stephen R. Farmer, Boston University School of Medicine, USA
Regulation of PPARgamma Expression and Function in the Adipocyte

Wednesday, February 05 | 8:00AM - 11:00AM
Molecular Mechanisms
Room: Grays Peak 1-2

Speaker 4 of 4
Robert G. Roeder, Rockefeller University, USA
Function of Distinct Transcriptional Coactivators in PPARgamma-Stimulated Adipogenesis

Wednesday, February 05 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Wednesday, February 05 | 11:00AM - 1:00PM
Poster Setup
Room: Longs Peak


Wednesday, February 05 | 1:00PM - 10:00PM
Poster Viewing
Room: Longs Peak


Wednesday, February 05 | 3:00PM - 4:30PM
Workshop 1: Hot Topics
Room: Grays Peak 1-2

Speaker 1 of 5
* Alan R. Tall, Columbia University, USA
A PEST Sequence in ABCA1 Regulates Degradation by Calpain Protease and Stabilization of ABCA1 by apoA-I

Wednesday, February 05 | 3:00PM - 4:30PM
Workshop 1: Hot Topics
Room: Grays Peak 1-2

Speaker 2 of 5
* V. Krishna K. Chatterjee, University of Cambridge, UK

Wednesday, February 05 | 3:00PM - 4:30PM
Workshop 1: Hot Topics
Room: Grays Peak 1-2

Speaker 3 of 5
Jae In Lee, Amgen Inc., USA
A Novel Transcriptional Coactivator Complex ASCOM and its Role in Lipid Metabolism

Wednesday, February 05 | 3:00PM - 4:30PM
Workshop 1: Hot Topics
Room: Grays Peak 1-2

Speaker 4 of 5
Bethany D. Freedman, Northwestern University Medical School, USA
Creation and Analysis of a Dominant Negative PPARgamma Knock-In Mouse

Wednesday, February 05 | 3:00PM - 4:30PM
Workshop 1: Hot Topics
Room: Grays Peak 1-2


Short Talk(s) Chosen from Abstracts

Wednesday, February 05 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Longs Peak Foyer


Wednesday, February 05 | 5:00PM - 7:00PM
Adipogenesis and Obesity
Room: Grays Peak 1-2

Speaker 1 of 3
Bruce M. Spiegelman, Harvard Medical School, USA
Control of Energy Metabolism and Cell Lineage Determination by PPARgamma and its Coactivators

Wednesday, February 05 | 5:00PM - 7:00PM
Adipogenesis and Obesity
Room: Grays Peak 1-2

Speaker 2 of 3
Barbara C. Hansen, University of South Florida, Tampa, USA
Differentiating the Functions of the PPARs

Wednesday, February 05 | 5:00PM - 7:00PM
Adipogenesis and Obesity
Room: Grays Peak 1-2

Speaker 3 of 3
V. Krishna K. Chatterjee, University of Cambridge, UK
PPARgamma: Lessons from Human Genetics

Wednesday, February 05 | 7:00PM - 8:00PM
Social Hour
Room: Longs Peak


Wednesday, February 05 | 8:00PM - 10:00PM
Poster Session 1: Molecular Mechanisms
Room: Longs Peak


Thursday, February 06 | 7:00AM - 8:00AM
Breakfast
Room: Longs Peak


Thursday, February 06 | 8:00AM - 11:00AM
Fatty Acid Metabolism
Room: Grays Peak 1-2

Speaker 1 of 4
Ronald M. Evans, HHMI/The Salk Institute, USA
PPARgamma and delta in Obesity, Diabetes and Heart Disease

Thursday, February 06 | 8:00AM - 11:00AM
Fatty Acid Metabolism
Room: Grays Peak 1-2

Speaker 2 of 4
Daniel P. Kelly, University of Pennsylvania, USA
Control of Mitochondrial Function by the PPARalpha/PGC-1 Axis in the Developing and Diseased Heart

Thursday, February 06 | 8:00AM - 11:00AM
Fatty Acid Metabolism
Room: Grays Peak 1-2

Speaker 3 of 4
Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA
PPARgamma, Adipogenesis and Insulin Sensitivity

Thursday, February 06 | 8:00AM - 11:00AM
Fatty Acid Metabolism
Room: Grays Peak 1-2

Speaker 4 of 4
George D. Yancopoulos, Regeneron Pharmaceuticals, Inc., USA
Axokine in Ongoing Obesity Trials, and Velocigene for What’s Next

Thursday, February 06 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Thursday, February 06 | 11:00AM - 1:00PM
Poster Setup
Room: Longs Peak


Thursday, February 06 | 1:00PM - 10:00PM
Poster Viewing
Room: Longs Peak


Thursday, February 06 | 3:00PM - 4:30PM
Workshop 2: Hot Topics
Room: Grays Peak 1-2

Speaker 1 of 5
* Barry Marc Forman, City of Hope, USA
Orphan Nuclear Receptors in Lipid Metabolism

Thursday, February 06 | 3:00PM - 4:30PM
Workshop 2: Hot Topics
Room: Grays Peak 1-2

Speaker 2 of 5
* Geoffrey D. Girnun, Stony Brook University, USA
APC-Dependent Suppression of Colon Carcinongenesis by PPARgamma

Thursday, February 06 | 3:00PM - 4:30PM
Workshop 2: Hot Topics
Room: Grays Peak 1-2

Speaker 3 of 5
George E.O. Muscat, University of Queensland, Australia
Regulation of Metabolism in Skeletal Muscle by PPARs

Thursday, February 06 | 3:00PM - 4:30PM
Workshop 2: Hot Topics
Room: Grays Peak 1-2

Speaker 4 of 5
Yau-Sheng Tsai, National Cheng Kung University, Taiwan
Hypertension but Not Overt Insulin Resistance in Mice with the P467L Mutation in PPARgamma

Thursday, February 06 | 3:00PM - 4:30PM
Workshop 2: Hot Topics
Room: Grays Peak 1-2


Short Talk(s) Chosen from Abstracts

Thursday, February 06 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Longs Peak Foyer


Thursday, February 06 | 5:00PM - 7:00PM
Glucose Homeostasis and Diabetes
Room: Grays Peak 1-2

Speaker 1 of 4
Willa A. Hsueh, Methodist Hospital Research Institute, USA
PPARgamma and Angiotensin II in the Vascular Disease in Diabetes

Thursday, February 06 | 5:00PM - 7:00PM
Glucose Homeostasis and Diabetes
Room: Grays Peak 1-2

Speaker 2 of 4
Jerrold M. Olefsky, University of California, San Diego, USA
Role of the PPARgamma Receptor in Muscle and Adipose Tissue Metabolism: Studies of Tissue Specific KO Mice

Thursday, February 06 | 5:00PM - 7:00PM
Glucose Homeostasis and Diabetes
Room: Grays Peak 1-2

Speaker 3 of 4
Takashi Kadowaki, University of Tokyo, Japan
The Role of PPARs in the Regulation of Insulin Sensitivity and Atherosclerosis

Thursday, February 06 | 5:00PM - 7:00PM
Glucose Homeostasis and Diabetes
Room: Grays Peak 1-2

Speaker 4 of 4
Ronald N. Margolis, NIDDK, National Institutes of Health, USA
Short Talk: An Orphan Nuclear Receptor Atlas

Thursday, February 06 | 7:00PM - 8:00PM
Social Hour
Room: Longs Peak


Thursday, February 06 | 8:00PM - 10:00PM
Poster Session 2: Metabolism
Room: Longs Peak


Friday, February 07 | 7:00AM - 8:00AM
Breakfast
Room: Longs Peak


Friday, February 07 | 8:00AM - 11:00AM
Cholesterol Homeostasis and Atherosclerosis
Room: Grays Peak 1-2

Speaker 1 of 5
Richard A. Heyman, ORIC Pharmaceuticals, USA
Orphan Nuclear Receptors as Drug Discovery Target for Metabolic Disease

Friday, February 07 | 8:00AM - 11:00AM
Cholesterol Homeostasis and Atherosclerosis
Room: Grays Peak 1-2

Speaker 2 of 5
Linda K. Curtiss, The Scripps Research Institute, USA
Plasma Phospholipid Transfer Protein (PLTP) is Expressed in Macrophages and Present in Atherosclerotic Lesions

Friday, February 07 | 8:00AM - 11:00AM
Cholesterol Homeostasis and Atherosclerosis
Room: Grays Peak 1-2

Speaker 3 of 5
David D. Moore, Baylor College of Medicine, USA
Orphan Receptors in the Enterohepatic Axis

Friday, February 07 | 8:00AM - 11:00AM
Cholesterol Homeostasis and Atherosclerosis
Room: Grays Peak 1-2

Speaker 4 of 5
Michael P. Czubryt, University of Manitoba, Canada
Short Talk: MEF2/HDAC5 Regulation of PGC-1alpha Expression and Mitochondrial Maintenance

Friday, February 07 | 8:00AM - 11:00AM
Cholesterol Homeostasis and Atherosclerosis
Room: Grays Peak 1-2

Speaker 5 of 5
Thomas P. Burris, Washington University School of Medicine, USA
Short Talk: Ligand and Coactivator Identity Determines the Requirement of the “Charge Clamp” of PPARgamma for Coactivation

Friday, February 07 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Friday, February 07 | 11:00AM - 1:00PM
Poster Setup
Room: Longs Peak


Friday, February 07 | 1:00PM - 10:00PM
Poster Viewing
Room: Longs Peak


Friday, February 07 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Longs Peak Foyer


Friday, February 07 | 5:00PM - 7:00PM
Glucose Homeostasis and Diabetes II
Room: Grays Peak 1-2

Speaker 1 of 3
C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA
Role of PPARgamma in Insulin Action and Gene Regulation in Skeletal Muscle

Friday, February 07 | 5:00PM - 7:00PM
Glucose Homeostasis and Diabetes II
Room: Grays Peak 1-2

Speaker 2 of 3
Peter Tontonoz, University of California, Los Angeles, USA
Role of PPARs and LXRs in Macrophage Lipid Metabolism

Friday, February 07 | 5:00PM - 7:00PM
Glucose Homeostasis and Diabetes II
Room: Grays Peak 1-2

Speaker 3 of 3
Timothy M. Willson, GlaxoSmithKline, USA
Structural Insights into the Regulation of Orphan Nuclear Receptors

Friday, February 07 | 7:00PM - 8:00PM
Social Hour
Room: Longs Peak


Friday, February 07 | 8:00PM - 10:00PM
Poster Session 3: Inflammation
Room: Longs Peak


Saturday, February 08 | 7:00AM - 8:00AM
Breakfast
Room: Longs Peak


Saturday, February 08 | 8:00AM - 11:00AM
Inflammation
Room: Grays Peak 1-2

Speaker 1 of 4
Bart Staels, Institut Pasteur de Lille, Université Lille, France
PPARs at the Crossroads of Lipid Metabolism and Inflammation Control

Saturday, February 08 | 8:00AM - 11:00AM
Inflammation
Room: Grays Peak 1-2

Speaker 2 of 4
Jorge Plutzky, Brigham and Women's Hospital, USA
PPARs as Modulators of the Inflammatory Response in the Vasculature

Saturday, February 08 | 8:00AM - 11:00AM
Inflammation
Room: Grays Peak 1-2

Speaker 3 of 4
Peter A. Edwards, UCLA, USA
Nuclear Receptors and Lipid Transport

Saturday, February 08 | 8:00AM - 11:00AM
Inflammation
Room: Grays Peak 1-2

Speaker 4 of 4
Laszlo Nagy, Sanford-Burnham Medical Research Institute at Lake Nona, USA
Short Talk: Activation of PPARgamma in Dendritic Cells Alters Their Differentiation and T-Cell Activating Specificity

Saturday, February 08 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Saturday, February 08 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Longs Peak Foyer


Saturday, February 08 | 5:00PM - 7:00PM
Differentiation and Cancer
Room: Grays Peak 1-2

Speaker 1 of 3
Walter Wahli, Nanyang Technological University, Singapore
Role of PPARs in Epidermal Differentiation

Saturday, February 08 | 5:00PM - 7:00PM
Differentiation and Cancer
Room: Grays Peak 1-2

Speaker 2 of 3
Philip W. Kantoff, Dana Farber Cancer Institute, USA
Is PPARgamma a Therapeutic Target in Prostate Cancer?

Saturday, February 08 | 5:00PM - 7:00PM
Differentiation and Cancer
Room: Grays Peak 1-2

Speaker 3 of 3
Frank J. Gonzalez, National Institutes of Health, USA
PPAR Null Mouse Update

Saturday, February 08 | 7:00PM - 8:00PM
Social Hour
Room: Longs Peak


Saturday, February 08 | 8:00PM - 11:00PM
Cash Bar
Room: Longs Peak


Saturday, February 08 | 8:00PM - 11:00PM
Entertainment
Room: Longs Peak


Sunday, February 09 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.