Web Desc
Molecular Mechanisms of Apoptosis
Organizer(s): Stephen W. Fesik, Xiaodong Wang, Craig B. Thompson
Date: February 08 - 13, 2003
Location: Fairmont Banff Springs, Banff, AB, Canada
Sponsored by Novartis Pharmaceuticals Corporation and The Director's Sponsor Fund
For important information on the coronavirus, please click here
Summary of Meeting:
Apoptosis is an important process for the removal of damaged or unwanted cells and when dysregulated can lead to several diseases. Recently, much has been learned about the biochemical pathways involved in programmed cell death as well as the three-dimensional structures of the proteins in these signaling pathways. In addition, data are emerging on how apoptosis is triggered and how late stage events in apoptosis are carried out. However, it will be important to learn how to utilize this information to better understand the role of apoptosis in disease and how to develop therapeutic agents to treat diseases caused by abberent cell death. In this Keystone Symposium, new biochemical pathways, three-dimensional structures, and information on early and late stage events in apoptosis will be discussed. The contribution of programmed cell death to disease and therapeutic approaches for treating these disorders will also be covered.
Discounted Abstract Deadline: October 8 2002
Discounted Registration Deadline: December 9 2002
We gratefully acknowledge additional support for this conference from:

Cell Signaling Technology, Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Saturday, February 08 | 3:00PM - 7:00PM
Registration
Room: Van Horne Foyer


Saturday, February 08 | 6:15PM - 7:15PM
Welcome
Room: Van Horne Foyer


Saturday, February 08 | 7:15PM - 7:30PM
Orientation
Room: Van Horne Ballroom AB


Saturday, February 08 | 7:30PM - 8:30PM
Keynote Address
Room: Van Horne Ballroom AB

Speaker 1 of 1
Shigekazu Nagata, IFReC, Osaka University, Japan
Breakdown of Chromosomal DNA during Apoptosis

Sunday, February 09 | 7:00AM - 8:00AM
Breakfast
Room: Riverview/Cascade/Conservatory


Sunday, February 09 | 8:00AM - 11:00AM
Identification of New Apoptotic Genes
Room: Van Horne Ballroom AB

Speaker 1 of 4
Karen H. Vousden, Francis Crick Institute, UK
Regulation of Cell Growth and Death by p53

Sunday, February 09 | 8:00AM - 11:00AM
Identification of New Apoptotic Genes
Room: Van Horne Ballroom AB

Speaker 2 of 4
Ding Xue, University of Colorado, USA
The Regulation and Execution of Apoptosis in C. elegans

Sunday, February 09 | 8:00AM - 11:00AM
Identification of New Apoptotic Genes
Room: Van Horne Ballroom AB

Speaker 3 of 4
John M. Abrams, University of Texas Southwestern Medical Center, USA
Molecular Genetics of Programmed and Unprogrammed Cell Death in Drosophila

Sunday, February 09 | 8:00AM - 11:00AM
Identification of New Apoptotic Genes
Room: Van Horne Ballroom AB

Speaker 4 of 4
* John C. Reed, Sanofi, France
Mechanisms and Modulators of Iap-Family Apoptosis Suppressors

Sunday, February 09 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Foyer


Sunday, February 09 | 11:00AM - 1:00PM
Poster Setup
Room: Alberta/New Brunswick


Sunday, February 09 | 1:00PM - 10:00PM
Poster Viewing
Room: Alberta/New Brunswick


Sunday, February 09 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Van Horne Foyer


Sunday, February 09 | 5:00PM - 7:00PM
Biochemical Pathways
Room: Van Horne Ballroom AB

Speaker 1 of 3
* Xiaodong Wang, BeiGene, China
Biochemical Studies of Apoptosis

Sunday, February 09 | 5:00PM - 7:00PM
Biochemical Pathways
Room: Van Horne Ballroom AB

Speaker 2 of 3
Richard J. Youle, NINDS, National Institutes of Health, USA
The Mechanism and Consequences of Bax Translocation to Mitochondria

Sunday, February 09 | 5:00PM - 7:00PM
Biochemical Pathways
Room: Van Horne Ballroom AB

Speaker 3 of 3
Marcus E. Peter, University of Chicago, USA
CD95 Type I and Type II Cells

Sunday, February 09 | 7:00PM - 8:00PM
Social Hour
Room: Alberta/New Brunswick


Sunday, February 09 | 8:00PM - 10:00PM
Poster Session 1
Room: Alberta/New Brunswick


Monday, February 10 | 7:00AM - 8:00AM
Breakfast
Room: Riverview/Cascade/Conservatory


Monday, February 10 | 8:00AM - 11:00AM
Initiation of Apoptosis
Room: Van Horne Ballroom AB

Speaker 1 of 4
Andreas E. Strasser, Walter and Eliza Hall Institute of Medical Research, Australia
BH3 Only Pro-Apoptotic Bcl-2 Family Members and More

Monday, February 10 | 8:00AM - 11:00AM
Initiation of Apoptosis
Room: Van Horne Ballroom AB

Speaker 2 of 4
* Junying Yuan, Harvard Medical School, USA
Pivotal Role of Oligomerization in Expanded Polyglutamine Neurodegeneration Disorders

Monday, February 10 | 8:00AM - 11:00AM
Initiation of Apoptosis
Room: Van Horne Ballroom AB

Speaker 3 of 4
Valter D. Longo, University of Southern California, USA
Regulation of Longevity and Stress Resistance in S. cerevisiae. Is Death Programmed?

Monday, February 10 | 8:00AM - 11:00AM
Initiation of Apoptosis
Room: Van Horne Ballroom AB

Speaker 4 of 4
John L. Cleveland, The Scripps Research Institute, USA
Pathways Regulating Apoptosis in Hematopoiesis and Cancer

Monday, February 10 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Foyer


Monday, February 10 | 11:00AM - 1:00PM
Poster Setup
Room: Alberta/New Brunswick


Monday, February 10 | 1:00PM - 10:00PM
Poster Viewing
Room: Alberta/New Brunswick


Monday, February 10 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Van Horne Foyer


Monday, February 10 | 5:00PM - 7:00PM
Clearance Mechanisms
Room: Van Horne Ballroom AB

Speaker 1 of 3
Kodi S. Ravichandran, University of Virginia, USA
Signaling to Engulfment - The Beginnings of a Good Meal

Monday, February 10 | 5:00PM - 7:00PM
Clearance Mechanisms
Room: Van Horne Ballroom AB

Speaker 2 of 3
Zheng Zhou, Baylor College of Medicine, USA
The Genetics of Hiding the Corpse

Monday, February 10 | 5:00PM - 7:00PM
Clearance Mechanisms
Room: Van Horne Ballroom AB

Speaker 3 of 3
* Philippe Chavrier, Laboratoire de la Dynamique du Cytosquelette, France
Function of the Small GTP-Binding Protein ARF6 in Membrane Dynamics during Phagocytosis

Monday, February 10 | 7:00PM - 8:00PM
Social Hour
Room: Alberta/New Brunswick


Monday, February 10 | 8:00PM - 10:00PM
Poster Session 2
Room: Alberta/New Brunswick


Tuesday, February 11 | 7:00AM - 8:00AM
Breakfast
Room: Rview/Oval/Cas/Cons


Tuesday, February 11 | 8:00AM - 11:00AM
Apoptosis in Disease
Room: Van Honre Ballroom AB

Speaker 1 of 4
Jennifer M. Puck, National Institutes of Health, USA
Autoimmune Lymphoproliferative Syndrome: What Underlies the Variations in Phenotype

Tuesday, February 11 | 8:00AM - 11:00AM
Apoptosis in Disease
Room: Van Honre Ballroom AB

Speaker 2 of 4
Richard N. Kitsis, Albert Einstein College of Medicine, USA
Manipulating Apoptosis in Heart Disease

Tuesday, February 11 | 8:00AM - 11:00AM
Apoptosis in Disease
Room: Van Honre Ballroom AB

Speaker 3 of 4
* Stanley J. Korsmeyer, Harvard University, USA
Dysregulation of Apoptotic Signaling Pathways Leading to Tumorigenesis


Tuesday, February 11 | 8:00AM - 11:00AM
Apoptosis in Disease
Room: Van Honre Ballroom AB

Speaker 4 of 4
Martin C. Raff, University College London, UK
Self-Destruct Programs in Neurons

Tuesday, February 11 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Foyer


Tuesday, February 11 | 11:00AM - 1:00PM
Poster Setup
Room: Alberta/New Brunswick


Tuesday, February 11 | 1:00PM - 10:00PM
Poster Viewing
Room: Alberta/New Brunswick


Tuesday, February 11 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Van Horne Foyer


Tuesday, February 11 | 5:00PM - 7:00PM
Therapeutic Applications
Room: Van Horne Ballroom AB

Speaker 1 of 3
* Donald W. Nicholson, Nimbus Discovery, Inc., USA
Caspase Modulation

Tuesday, February 11 | 5:00PM - 7:00PM
Therapeutic Applications
Room: Van Horne Ballroom AB

Speaker 2 of 3
Saul H. Rosenberg, Abbott Laboratories, USA
Small Molecular Inhibitors of Bcl-2 Family Proteins for the Treatment of Cancer

Tuesday, February 11 | 5:00PM - 7:00PM
Therapeutic Applications
Room: Van Horne Ballroom AB

Speaker 3 of 3
Vishva M. Dixit, Genentech, Inc., USA
New Players in an Old Field - Novel TNF Family Members

Tuesday, February 11 | 7:00PM - 8:00PM
Social Hour
Room: Alberta/New Brunswick


Tuesday, February 11 | 8:00PM - 10:00PM
Poster Session 3
Room: Alberta/New Brunswick


Wednesday, February 12 | 7:00AM - 8:00AM
Breakfast
Room: Riverview/Cascade/Conservatory


Wednesday, February 12 | 8:00AM - 11:00AM
Structural Biology
Room: Van Horne Ballroom AB

Speaker 1 of 4
Martin Renatus, Novartis Pharma AG, Switzerland
Structure Basis for Caspase Activation and Regulation

Wednesday, February 12 | 8:00AM - 11:00AM
Structural Biology
Room: Van Horne Ballroom AB

Speaker 2 of 4
* Yigong Shi, Tsinghua University School of Medicine, China
A Conserved Mechanism of Caspase Activation

Wednesday, February 12 | 8:00AM - 11:00AM
Structural Biology
Room: Van Horne Ballroom AB

Speaker 3 of 4
Gerhard Wagner, Harvard Medical School, USA
Structures of Proteins Involved in Signaling of Apoptosis

Wednesday, February 12 | 8:00AM - 11:00AM
Structural Biology
Room: Van Horne Ballroom AB

Speaker 4 of 4
Nico Tjandra, National Institutes of Health, USA
NMR Study of Bax

Wednesday, February 12 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Foyer


Wednesday, February 12 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Van Horne Foyer


Wednesday, February 12 | 5:00PM - 7:00PM
Late Breaking Developments
Room: Van Horne Ballroom AB

Speaker 1 of 4
* Jürg Tschopp, University of Lausanne, Switzerland
Activation of Pro-Inflammatory Caspases by NALP Family Members

Wednesday, February 12 | 5:00PM - 7:00PM
Late Breaking Developments
Room: Van Horne Ballroom AB

Speaker 2 of 4
Jennifer A. Straub, University of Rochester, USA
Short Talk: A Role for Prolyl Hydroxylation in Trophic Factor Deprivation-Induced Neuronal Cell Death

Wednesday, February 12 | 5:00PM - 7:00PM
Late Breaking Developments
Room: Van Horne Ballroom AB

Speaker 3 of 4
Kejie Yin, Washington University School of Medicine, USA
Short Talk: ABeta-Induced Cell Death Involves smac Release and Endonuclease G Translocation from Mitochondria via Inhibition of Akt Activity in Cerebrovascular Endothelial Cells

Wednesday, February 12 | 5:00PM - 7:00PM
Late Breaking Developments
Room: Van Horne Ballroom AB

Speaker 4 of 4
Yihru Fannjiang, Johns Hopkins University, USA
Short Talk: The Role of Yar-1 in Saccharomyces cerevisiae Programmed Cell Death

Wednesday, February 12 | 7:15PM - 8:15PM
Social Hour
Room: Alberta/New Brunswick


Wednesday, February 12 | 8:15PM - 11:15PM
Entertainment
Room: Alberta/New Brunswick


Wednesday, February 12 | 8:15PM - 11:15PM
Cash Bar
Room: Alberta/New Brunswick


Thursday, February 13 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.