Web Desc
Transposition and Other Genome Rearrangements
Organizer(s): Tania A. Baker, Ronald Plasterk, Daniel F. Voytas
Date: February 08 - 14, 2003
Location: Hilton Santa Fe Historic Plaza Hotel, Santa Fe, NM, USA
Sponsored in part by The Director's Sponsor Fund
Summary of Meeting:
Transposons are a powerful creative force. The recent sequence of the human genome reveals that 45% of the DNA and about 50 genes appear to be transposon-derived. Transposition and related recombination reactions are responsible for generating antibody diversity, altering antigen expression, integration of retroviruses, and the horizontal transmission of virulence factors. Current research is aimed at understanding: (1) recombination mechanisms, using biochemical and structural approaches; (2) their regulation by the environment and during development; and (3) how these events affect cellular function and organism evolution. In this post-genomic era, transposition and site-specific recombination have also been embraced as tools for genome analysis and manipulation. This meeting will bring together researchers interested in all aspects of specialized recombination, from the biological to the structural and mechanistic. Research probing recombination in diverse organisms--including microbes, plants, and animals--will be presented to facilitate exchange of information and ideas, and encourage participants to reach out in new directions.
Discounted Abstract Deadline: October 8 2002
Discounted Registration Deadline: December 9 2002
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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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Program

Saturday, February 08 | 3:00PM - 7:00PM
Registration
Room: Promenade


Saturday, February 08 | 6:15PM - 7:15PM
Welcome
Room: Promenade


Saturday, February 08 | 7:15PM - 7:30PM
Orientation
Room: Mesa A-B


Saturday, February 08 | 7:30PM - 8:30PM
Keynote Address
Room: Mesa A-B

Speaker 1 of 1
Jef D. Boeke, New York University Langone Medical Center, USA
The Host-Retrotransposon Interface

Sunday, February 09 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa


Sunday, February 09 | 8:00AM - 11:15AM
Classical Transposons: Mechanism and Control
Room: Mesa A-B

Speaker 1 of 6
Patrick A. Pribil, University of Maryland, USA
Target DNA Modifications that Enhance Target Capture and Strand Transfer in Tn10 Transposition

Sunday, February 09 | 8:00AM - 11:15AM
Classical Transposons: Mechanism and Control
Room: Mesa A-B

Speaker 2 of 6
Kiyoshi Mizuuchi, NIDDK, National Institutes of Health, USA
Mu Transposition Complex Assembly Dynamics and Target Site Selection

Sunday, February 09 | 8:00AM - 11:15AM
Classical Transposons: Mechanism and Control
Room: Mesa A-B

Speaker 3 of 6
Tai Kong Au, University of Texas at Austin, USA
Short Talk: Disintegration of Mu Strand Transfer Complexes: Implications for Target Site Conformation

Sunday, February 09 | 8:00AM - 11:15AM
Classical Transposons: Mechanism and Control
Room: Mesa A-B

Speaker 4 of 6
Tania A. Baker, Massachusetts Institute of Technology, USA
Alternative Pathways of Mu Transposition

Sunday, February 09 | 8:00AM - 11:15AM
Classical Transposons: Mechanism and Control
Room: Mesa A-B

Speaker 5 of 6
* Nancy L. Craig, Johns Hopkins University School of Medicine, USA
Tn7

Sunday, February 09 | 8:00AM - 11:15AM
Classical Transposons: Mechanism and Control
Room: Mesa A-B

Speaker 6 of 6
Donald R. Ronning, University of Nebraska Medical Center, USA
Short Talk: TnsA/TnsC C-Terminal Tail Structure: The Glue that Binds Tn7

Sunday, February 09 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Sunday, February 09 | 11:00AM - 1:00PM
Poster Setup
Room: Mesa C


Sunday, February 09 | 1:00PM - 10:00PM
Poster Viewing
Room: Mesa C


Sunday, February 09 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Promenade


Sunday, February 09 | 5:00PM - 7:00PM
Conservative Site Specific Recombination
Room: Mesa A-B

Speaker 1 of 4
* Reid C. Johnson, University of California, Los Angeles, USA
Inversion by the Hin-Fis Protein Complex

Sunday, February 09 | 5:00PM - 7:00PM
Conservative Site Specific Recombination
Room: Mesa A-B

Speaker 2 of 4
Nigel D. F. Grindley, Yale University, USA
Site-Specific Recombination by Gamma-Delta Resolvase: Assessing the 'Filament' Model for the Synaptic Complex

Sunday, February 09 | 5:00PM - 7:00PM
Conservative Site Specific Recombination
Room: Mesa A-B

Speaker 3 of 4
David J. Sherratt, University of Oxford, UK
Chromosome Dimer Resolution by FtsK-Dependent XerCD Recombination at dif

Sunday, February 09 | 5:00PM - 7:00PM
Conservative Site Specific Recombination
Room: Mesa A-B

Speaker 4 of 4
Kerren Swinger, University of Chicago, USA
Short Talk: Flexible DNA Bending in HU-DNA Cocrystal Structures

Sunday, February 09 | 7:00PM - 8:00PM
Social Hour
Room: Mesa C


Sunday, February 09 | 8:00PM - 10:00PM
Poster Session 1: Classical Elements, Recombinase Mechanism
and Structure
Room: Mesa C


Monday, February 10 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa


Monday, February 10 | 8:00AM - 11:15AM
Retrotransposition
Room: Mesa A-B

Speaker 1 of 6
* Thomas H. Eickbush, University of Rochester, USA
Retrotransposons that Propagate in the Nucleolus

Monday, February 10 | 8:00AM - 11:15AM
Retrotransposition
Room: Mesa A-B

Speaker 2 of 6
Suzanne B. Sandmeyer, University of California, Irvine, USA
Host Genes Supporting Ty3 Retrotransposition

Monday, February 10 | 8:00AM - 11:15AM
Retrotransposition
Room: Mesa A-B

Speaker 3 of 6
Henry L. Levin, NIH, USA
The Retrotransposon Tf1 of Schizosaccharomyces pombe as a Model for the Study of Particle Formation, Reverse Transcription and Integration

Monday, February 10 | 8:00AM - 11:15AM
Retrotransposition
Room: Mesa A-B

Speaker 4 of 6
John V. Moran, University of Michigan Medical School, USA
Studies of a Human Retrotransposon

Monday, February 10 | 8:00AM - 11:15AM
Retrotransposition
Room: Mesa A-B

Speaker 5 of 6
Abram Gabriel, Rutgers University, USA
Short Talk: Biochemical Analysis of a Ty1 RT Active Site Mutant that Retains Polymerase Activity

Monday, February 10 | 8:00AM - 11:15AM
Retrotransposition
Room: Mesa A-B

Speaker 6 of 6
Sandra L. Martin, University of Colorado Denver, Anschutz Medical Campus, USA
Short Talk: Structural and Functional Analyses of the ORF1 Protein from Mouse LINE-1: Implications for Retrotransposition

Monday, February 10 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Monday, February 10 | 11:00AM - 1:00PM
Poster Setup
Room: Mesa C


Monday, February 10 | 1:00PM - 10:00PM
Poster Viewing
Room: Mesa C


Monday, February 10 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Promenade


Monday, February 10 | 5:00PM - 7:00PM
Recombinase Structure and Function
Room: Mesa A-B

Speaker 1 of 4
* Gregory D. Van Duyne, University of Pennsylvania School of Medicine, USA
Cre-loxP Recombination: Synapsis of loxP Sites

Monday, February 10 | 5:00PM - 7:00PM
Recombinase Structure and Function
Room: Mesa A-B

Speaker 2 of 4
William S. Reznikoff, Marine Biological Laboratory, USA
Relating Structure to Mechanism for Tn5 Transposition

Monday, February 10 | 5:00PM - 7:00PM
Recombinase Structure and Function
Room: Mesa A-B

Speaker 3 of 4
Alison Burgess Hickman, National Institutes of Health, USA
The Nuclease Domain of AAV Rep: A Role in Site-Specific Integration

Monday, February 10 | 5:00PM - 7:00PM
Recombinase Structure and Function
Room: Mesa A-B

Speaker 4 of 4
Isaac Wong, Oregon State University, USA
Short Talk: Functional Oligomeric State of ASV Integrase

Monday, February 10 | 7:00PM - 8:00PM
Social Hour
Room: Mesa C


Monday, February 10 | 8:00PM - 10:00PM
Poster Session 2: Retrotransposition
Room: Mesa C


Tuesday, February 11 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa


Tuesday, February 11 | 8:00AM - 11:00AM
Transposition Silencing and RNAi
Room: Mesa A-B

Speaker 1 of 6
* Ronald H. Plasterk, Ministry of Education, Culture and Science, Netherlands
Transposon Silencing and RNAi in C. elegans

Tuesday, February 11 | 8:00AM - 11:00AM
Transposition Silencing and RNAi
Room: Mesa A-B

Speaker 2 of 6
Robert A. Martienssen, Cold Spring Harbor Laboratory, USA
Transposons and Related Repeats Mediate Heterochromatin Formation via RNA Interference

Tuesday, February 11 | 8:00AM - 11:00AM
Transposition Silencing and RNAi
Room: Mesa A-B

Speaker 3 of 6
Heriberto D. Cerutti, University of Nebraska, USA
Epigenetic Silencing of Transposable Elements in Chlamydomonas

Tuesday, February 11 | 8:00AM - 11:00AM
Transposition Silencing and RNAi
Room: Mesa A-B

Speaker 4 of 6
David J. Garfinkel, National Cancer Institute, National Institutes of Health, USA
Short Talk: Copy Number Control of Ty1 Retrotransposition

Tuesday, February 11 | 8:00AM - 11:00AM
Transposition Silencing and RNAi
Room: Mesa A-B

Speaker 5 of 6
Jean-Marc Deragon, Universite Blaise Pascal, France
Short Talk: Expression of a SINE Founder Locus Results in the Accumulation of Stable PolyA-Ending RNAs

Tuesday, February 11 | 8:00AM - 11:00AM
Transposition Silencing and RNAi
Room: Mesa A-B

Speaker 6 of 6
Damon R. Lisch, University of California, Berkeley, USA
Short Talk: Epigenetic Silencing and Reactivation of the Maize Transposon MuDR

Tuesday, February 11 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Tuesday, February 11 | 11:00AM - 1:00PM
Poster Setup
Room: Mesa C


Tuesday, February 11 | 1:00PM - 10:00PM
Poster Viewing
Room: Mesa C


Tuesday, February 11 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Promenade


Tuesday, February 11 | 5:00PM - 7:00PM
Unusual Elements and Reactions
Room: Mesa A-B

Speaker 1 of 4
* George Chaconas, University of Calgary, Canada
Telomere Resolution in the Lyme Disease Spirochete: Mechanistic Similarities to Site-Specific Recombination and DNA Transposition

Tuesday, February 11 | 5:00PM - 7:00PM
Unusual Elements and Reactions
Room: Mesa A-B

Speaker 2 of 4
Alan M. Lambowitz, University of Texas at Austin, USA
Group II Intron Mobility by Reverse Splicing into DNA and its Applications in Targeted Gene Disruption and Site-Specific DNA Insertion

Tuesday, February 11 | 5:00PM - 7:00PM
Unusual Elements and Reactions
Room: Mesa A-B

Speaker 3 of 4
Marlene Belfort, University of Albany, SUNY, USA
Mobile Introns: Function and Evolution

Tuesday, February 11 | 5:00PM - 7:00PM
Unusual Elements and Reactions
Room: Mesa A-B

Speaker 4 of 4
Russell T.M. Poulter, University of Otago, New Zealand
Short Talk: A Mini-Intein in Cryptococcus

Tuesday, February 11 | 7:00PM - 8:00PM
Social Hour
Room: Mesa C


Tuesday, February 11 | 8:00PM - 10:00PM
Poster Session 3: Recombination in Development, Homing and U
nusual Reactions
Room: Mesa C


Wednesday, February 12 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa


Wednesday, February 12 | 8:00AM - 11:00AM
Developmentally Programmed Rearrangements
Room: Mesa A-B

Speaker 1 of 5
* Martin Gellert, NIDDK, National Institutes of Health, USA
Multiple Roles of the Rag Proteins in Recombination and Transposition

Wednesday, February 12 | 8:00AM - 11:00AM
Developmentally Programmed Rearrangements
Room: Mesa A-B

Speaker 2 of 5
Meng-Chao Yao, Fred Hutchinson Cancer Research Center, USA
Programmed Genome Rearrangements in Tetrahymena: An RNA-Guided System of Genome Defense

Wednesday, February 12 | 8:00AM - 11:00AM
Developmentally Programmed Rearrangements
Room: Mesa A-B

Speaker 3 of 5
Zsuzsanna Izsvak, Max-Delbrück Center, Germany
Short Talk: NHEJ Factors and ATM are both Required for Healing the Wounds Inflicted by Sleeping Beauty Transposition in Mammalian Cells

Wednesday, February 12 | 8:00AM - 11:00AM
Developmentally Programmed Rearrangements
Room: Mesa A-B

Speaker 4 of 5
Koichi Kawakami, National Institute of Genetics, Japan
Short Talk: Transposition of the Tol2 Element of the Japanese Medaka Fish Oryzias latipes in Vertebrates

Wednesday, February 12 | 8:00AM - 11:00AM
Developmentally Programmed Rearrangements
Room: Mesa A-B

Speaker 5 of 5
Lindsay Grey Cowell, Duke University Medical Center, USA
Short Talk: Phylogenetic Conservation of Recombination Signals Flanking Rag-1 and Rag-2

Wednesday, February 12 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Wednesday, February 12 | 11:00AM - 1:00PM
Poster Setup
Room: Mesa C


Wednesday, February 12 | 1:00PM - 10:00PM
Poster Viewing
Room: Mesa C


Wednesday, February 12 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Promenade


Wednesday, February 12 | 5:00PM - 7:00PM
Transposon Functions and Consequences
Room: Mesa A-B

Speaker 1 of 4
* William R. Engels, University of Wisconsin-Madison, USA
Double-Strand Break Repair in Drosophila

Wednesday, February 12 | 5:00PM - 7:00PM
Transposon Functions and Consequences
Room: Mesa A-B

Speaker 2 of 4
Mary-Lou Pardue, Massachusetts Institute of Technology, USA
Fitting into the Establishment: The Two Drosophila Telomeric Retrotransposons



Wednesday, February 12 | 5:00PM - 7:00PM
Transposon Functions and Consequences
Room: Mesa A-B

Speaker 3 of 4
Zoltan Ivics, Paul Ehrlich Institute, Germany
Sleeping Beauty: Evolution, Regulation and Genetic Applications in Vertebrates

Wednesday, February 12 | 5:00PM - 7:00PM
Transposon Functions and Consequences
Room: Mesa A-B

Speaker 4 of 4
Thomas Peterson, Iowa State University, USA
Short Talk: Transposition of Reversed Ac Element Ends Shuffles Exons and Rearranges Chromosomes in Maize

Wednesday, February 12 | 7:00PM - 8:00PM
Social Hour
Room: Mesa C


Wednesday, February 12 | 8:00PM - 10:00PM
Poster Session 4: Genomes and Evolution
Room: Mesa C


Thursday, February 13 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa


Thursday, February 13 | 8:00AM - 11:15AM
Host-Transposon Communication and Regulation
Room: Mesa A-B

Speaker 1 of 6
* Daniel F. Voytas, University of Minnesota, USA
Retrotransposition and Heterochromatin in Baker’s Yeast

Thursday, February 13 | 8:00AM - 11:15AM
Host-Transposon Communication and Regulation
Room: Mesa A-B

Speaker 2 of 6
Reinhard Kunze, University of Cologne, Germany
The Maize Ac/Ds Transposable Elements: Regulation and Manipulation of Transposition Activity

Thursday, February 13 | 8:00AM - 11:15AM
Host-Transposon Communication and Regulation
Room: Mesa A-B

Speaker 3 of 6
Donald Rio, University of California, Berkeley, USA
Mechanism and Regulation of Drosophila P Element Transposition

Thursday, February 13 | 8:00AM - 11:15AM
Host-Transposon Communication and Regulation
Room: Mesa A-B

Speaker 4 of 6
M. Joan Curcio, Wadsworth Center, USA
Activation of LTR-Retrotransposons in Telomerase-Negative Yeast Mutants

Thursday, February 13 | 8:00AM - 11:15AM
Host-Transposon Communication and Regulation
Room: Mesa A-B

Speaker 5 of 6
Scott E. Devine, Emory University School of Medicine, USA
Short Talk: Functional Genomics Reveals Relationships between the Retrovirus-Like Ty1 Element and its Host

Thursday, February 13 | 8:00AM - 11:15AM
Host-Transposon Communication and Regulation
Room: Mesa A-B

Speaker 6 of 6
Ping Zhang, University of Connecticut, USA
Short Talk: Timing and Targeting of P-Element Local Transposition in the Male Germ Line Cells of Drosophila melanogaster

Thursday, February 13 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Thursday, February 13 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Promenade


Thursday, February 13 | 5:00PM - 7:00PM
Transposons and Genome Organization
Room: Mesa A-B

Speaker 1 of 5
* Haig H. Kazazian, Johns Hopkins University School of Medicine, USA
Further Estimates of the Frequency of Retrotransposition Events in Humans

Thursday, February 13 | 5:00PM - 7:00PM
Transposons and Genome Organization
Room: Mesa A-B

Speaker 2 of 5
Susan R. Wessler, University of California, Riverside, USA
Rice as a Model System to Understand the Origin and Spread of MITEs

Thursday, February 13 | 5:00PM - 7:00PM
Transposons and Genome Organization
Room: Mesa A-B

Speaker 3 of 5
Dixie L. Mager, British Columbia Cancer Agency, Canada
Short Talk: ETn Retrotransposons and Related Type D Endogenous Retroviral Elements in the Mouse

Thursday, February 13 | 5:00PM - 7:00PM
Transposons and Genome Organization
Room: Mesa A-B

Speaker 4 of 5
Hugh M. Robertson, University of Illinois at Urbana-Champaign, USA
Short Talk: Molecular Evolution of Eeyore/TIGD1 and Nine Other Human Genes Derived from Tigger/pogo DNA Transposons

Thursday, February 13 | 5:00PM - 7:00PM
Transposons and Genome Organization
Room: Mesa A-B

Speaker 5 of 5
Zhijian (Jake) Tu, Virginia Polytechnic Institute and State University, USA
Short Talk: Mosquito Transposable Elements: A Genomic and Evolutionary Perspective

Thursday, February 13 | 7:00PM - 8:00PM
Social Hour
Room: Mesa C


Thursday, February 13 | 8:00PM - 11:00PM
Entertainment
Room: Mesa C


Thursday, February 13 | 8:00PM - 11:00PM
Cash Bar
Room: Mesa C


Friday, February 14 | 10:26AM - 10:26AM
Departure


*Session Chair.