Past Meeting | Keystone Symposia

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Precision Genome Engineering and Synthetic Biology: Designing Genomes and Pathways (2013C5)

Web Desc
Transposition and Other Genome Rearrangements Organizer(s): Tania A. Baker, Ronald Plasterk, Daniel F. Voytas Date: February 08 - 14, 2003 Location: Hilton Santa Fe Historic Plaza Hotel, Santa Fe, NM, USA Sponsored in part by The Director's Sponsor Fund Summary of Meeting: Transposons are a powerful creative force. The recent sequence of the human genome reveals that 45% of the DNA and about 50 genes appear to be transposon-derived. Transposition and related recombination reactions are responsible for generating antibody diversity, altering antigen expression, integration of retroviruses, and the horizontal transmission of virulence factors. Current research is aimed at understanding: (1) recombination mechanisms, using biochemical and structural approaches; (2) their regulation by the environment and during development; and (3) how these events affect cellular function and organism evolution. In this post-genomic era, transposition and site-specific recombination have also been embraced as tools for genome analysis and manipulation. This meeting will bring together researchers interested in all aspects of specialized recombination, from the biological to the structural and mechanistic. Research probing recombination in diverse organisms--including microbes, plants, and animals--will be presented to facilitate exchange of information and ideas, and encourage participants to reach out in new directions. Discounted Abstract Deadline: October 8 2002 Discounted Registration Deadline: December 9 2002 We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

Transposition and Other Genome Rearrangements

Organizer(s): Tania A. Baker, Ronald Plasterk, Daniel F. Voytas

Date: February 08 - 14, 2003
Location: Hilton Santa Fe Historic Plaza Hotel, Santa Fe, NM, USA

Sponsored in part by The Director's Sponsor Fund

Summary of Meeting:

Transposons are a powerful creative force. The recent sequence of the human genome reveals that 45% of the DNA and about 50 genes appear to be transposon-derived. Transposition and related recombination reactions are responsible for generating antibody diversity, altering antigen expression, integration of retroviruses, and the horizontal transmission of virulence factors. Current research is aimed at understanding: (1) recombination mechanisms, using biochemical and structural approaches; (2) their regulation by the environment and during development; and (3) how these events affect cellular function and organism evolution. In this post-genomic era, transposition and site-specific recombination have also been embraced as tools for genome analysis and manipulation. This meeting will bring together researchers interested in all aspects of specialized recombination, from the biological to the structural and mechanistic. Research probing recombination in diverse organisms--including microbes, plants, and animals--will be presented to facilitate exchange of information and ideas, and encourage participants to reach out in new directions.

Discounted Abstract Deadline: October 8 2002

Discounted Registration Deadline: December 9 2002

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Saturday, February 08 \| 3:00PM - 7:00PM Registration Room: Promenade
Saturday, February 08 \| 6:15PM - 7:15PM Welcome Room: Promenade
Saturday, February 08 \| 7:15PM - 7:30PM Orientation Room: Mesa A-B
Saturday, February 08 \| 7:30PM - 8:30PM Keynote Address Room: Mesa A-B Speaker 1 of 1 Jef D. Boeke, New York University Langone Medical Center, USA The Host-Retrotransposon Interface
Sunday, February 09 \| 7:00AM - 8:00AM Breakfast Room: Chamisa
Sunday, February 09 \| 8:00AM - 11:15AM Classical Transposons: Mechanism and Control Room: Mesa A-B Speaker 1 of 6 Patrick A. Pribil, University of Maryland, USA Target DNA Modifications that Enhance Target Capture and Strand Transfer in Tn10 Transposition
Sunday, February 09 \| 8:00AM - 11:15AM Classical Transposons: Mechanism and Control Room: Mesa A-B Speaker 2 of 6 Kiyoshi Mizuuchi, NIDDK, National Institutes of Health, USA Mu Transposition Complex Assembly Dynamics and Target Site Selection
Sunday, February 09 \| 8:00AM - 11:15AM Classical Transposons: Mechanism and Control Room: Mesa A-B Speaker 3 of 6 Tai Kong Au, University of Texas at Austin, USA Short Talk: Disintegration of Mu Strand Transfer Complexes: Implications for Target Site Conformation
Sunday, February 09 \| 8:00AM - 11:15AM Classical Transposons: Mechanism and Control Room: Mesa A-B Speaker 4 of 6 Tania A. Baker, Massachusetts Institute of Technology, USA Alternative Pathways of Mu Transposition
Sunday, February 09 \| 8:00AM - 11:15AM Classical Transposons: Mechanism and Control Room: Mesa A-B Speaker 5 of 6 * Nancy L. Craig, Johns Hopkins University School of Medicine, USA Tn7
Sunday, February 09 \| 8:00AM - 11:15AM Classical Transposons: Mechanism and Control Room: Mesa A-B Speaker 6 of 6 Donald R. Ronning, University of Nebraska Medical Center, USA Short Talk: TnsA/TnsC C-Terminal Tail Structure: The Glue that Binds Tn7
Sunday, February 09 \| 9:20AM - 9:40AM Coffee Break Room: Promenade
Sunday, February 09 \| 11:00AM - 1:00PM Poster Setup Room: Mesa C
Sunday, February 09 \| 1:00PM - 10:00PM Poster Viewing Room: Mesa C
Sunday, February 09 \| 4:30PM - 5:00PM Coffee & Snacks Available Room: Promenade
Sunday, February 09 \| 5:00PM - 7:00PM Conservative Site Specific Recombination Room: Mesa A-B Speaker 1 of 4 * Reid C. Johnson, University of California, Los Angeles, USA Inversion by the Hin-Fis Protein Complex
Sunday, February 09 \| 5:00PM - 7:00PM Conservative Site Specific Recombination Room: Mesa A-B Speaker 2 of 4 Nigel D. F. Grindley, Yale University, USA Site-Specific Recombination by Gamma-Delta Resolvase: Assessing the 'Filament' Model for the Synaptic Complex
Sunday, February 09 \| 5:00PM - 7:00PM Conservative Site Specific Recombination Room: Mesa A-B Speaker 3 of 4 David J. Sherratt, University of Oxford, UK Chromosome Dimer Resolution by FtsK-Dependent XerCD Recombination at dif
Sunday, February 09 \| 5:00PM - 7:00PM Conservative Site Specific Recombination Room: Mesa A-B Speaker 4 of 4 Kerren Swinger, University of Chicago, USA Short Talk: Flexible DNA Bending in HU-DNA Cocrystal Structures
Sunday, February 09 \| 7:00PM - 8:00PM Social Hour Room: Mesa C
Sunday, February 09 \| 8:00PM - 10:00PM Poster Session 1: Classical Elements, Recombinase Mechanism and Structure Room: Mesa C
Monday, February 10 \| 7:00AM - 8:00AM Breakfast Room: Chamisa
Monday, February 10 \| 8:00AM - 11:15AM Retrotransposition Room: Mesa A-B Speaker 1 of 6 * Thomas H. Eickbush, University of Rochester, USA Retrotransposons that Propagate in the Nucleolus
Monday, February 10 \| 8:00AM - 11:15AM Retrotransposition Room: Mesa A-B Speaker 2 of 6 Suzanne B. Sandmeyer, University of California, Irvine, USA Host Genes Supporting Ty3 Retrotransposition
Monday, February 10 \| 8:00AM - 11:15AM Retrotransposition Room: Mesa A-B Speaker 3 of 6 Henry L. Levin, NIH, USA The Retrotransposon Tf1 of Schizosaccharomyces pombe as a Model for the Study of Particle Formation, Reverse Transcription and Integration
Monday, February 10 \| 8:00AM - 11:15AM Retrotransposition Room: Mesa A-B Speaker 4 of 6 John V. Moran, University of Michigan Medical School, USA Studies of a Human Retrotransposon
Monday, February 10 \| 8:00AM - 11:15AM Retrotransposition Room: Mesa A-B Speaker 5 of 6 Abram Gabriel, Rutgers University, USA Short Talk: Biochemical Analysis of a Ty1 RT Active Site Mutant that Retains Polymerase Activity
Monday, February 10 \| 8:00AM - 11:15AM Retrotransposition Room: Mesa A-B Speaker 6 of 6 Sandra L. Martin, University of Colorado Denver, Anschutz Medical Campus, USA Short Talk: Structural and Functional Analyses of the ORF1 Protein from Mouse LINE-1: Implications for Retrotransposition
Monday, February 10 \| 9:20AM - 9:40AM Coffee Break Room: Promenade
Monday, February 10 \| 11:00AM - 1:00PM Poster Setup Room: Mesa C
Monday, February 10 \| 1:00PM - 10:00PM Poster Viewing Room: Mesa C
Monday, February 10 \| 4:30PM - 5:00PM Coffee & Snacks Available Room: Promenade
Monday, February 10 \| 5:00PM - 7:00PM Recombinase Structure and Function Room: Mesa A-B Speaker 1 of 4 * Gregory D. Van Duyne, University of Pennsylvania School of Medicine, USA Cre-loxP Recombination: Synapsis of loxP Sites
Monday, February 10 \| 5:00PM - 7:00PM Recombinase Structure and Function Room: Mesa A-B Speaker 2 of 4 William S. Reznikoff, Marine Biological Laboratory, USA Relating Structure to Mechanism for Tn5 Transposition
Monday, February 10 \| 5:00PM - 7:00PM Recombinase Structure and Function Room: Mesa A-B Speaker 3 of 4 Alison Burgess Hickman, National Institutes of Health, USA The Nuclease Domain of AAV Rep: A Role in Site-Specific Integration
Monday, February 10 \| 5:00PM - 7:00PM Recombinase Structure and Function Room: Mesa A-B Speaker 4 of 4 Isaac Wong, Oregon State University, USA Short Talk: Functional Oligomeric State of ASV Integrase
Monday, February 10 \| 7:00PM - 8:00PM Social Hour Room: Mesa C
Monday, February 10 \| 8:00PM - 10:00PM Poster Session 2: Retrotransposition Room: Mesa C
Tuesday, February 11 \| 7:00AM - 8:00AM Breakfast Room: Chamisa
Tuesday, February 11 \| 8:00AM - 11:00AM Transposition Silencing and RNAi Room: Mesa A-B Speaker 1 of 6 * Ronald H. Plasterk, Ministry of Education, Culture and Science, Netherlands Transposon Silencing and RNAi in C. elegans
Tuesday, February 11 \| 8:00AM - 11:00AM Transposition Silencing and RNAi Room: Mesa A-B Speaker 2 of 6 Robert A. Martienssen, Cold Spring Harbor Laboratory, USA Transposons and Related Repeats Mediate Heterochromatin Formation via RNA Interference
Tuesday, February 11 \| 8:00AM - 11:00AM Transposition Silencing and RNAi Room: Mesa A-B Speaker 3 of 6 Heriberto D. Cerutti, University of Nebraska, USA Epigenetic Silencing of Transposable Elements in Chlamydomonas
Tuesday, February 11 \| 8:00AM - 11:00AM Transposition Silencing and RNAi Room: Mesa A-B Speaker 4 of 6 David J. Garfinkel, National Cancer Institute, National Institutes of Health, USA Short Talk: Copy Number Control of Ty1 Retrotransposition
Tuesday, February 11 \| 8:00AM - 11:00AM Transposition Silencing and RNAi Room: Mesa A-B Speaker 5 of 6 Jean-Marc Deragon, Universite Blaise Pascal, France Short Talk: Expression of a SINE Founder Locus Results in the Accumulation of Stable PolyA-Ending RNAs
Tuesday, February 11 \| 8:00AM - 11:00AM Transposition Silencing and RNAi Room: Mesa A-B Speaker 6 of 6 Damon R. Lisch, University of California, Berkeley, USA Short Talk: Epigenetic Silencing and Reactivation of the Maize Transposon MuDR
Tuesday, February 11 \| 9:20AM - 9:40AM Coffee Break Room: Promenade
Tuesday, February 11 \| 11:00AM - 1:00PM Poster Setup Room: Mesa C
Tuesday, February 11 \| 1:00PM - 10:00PM Poster Viewing Room: Mesa C
Tuesday, February 11 \| 4:30PM - 5:00PM Coffee & Snacks Available Room: Promenade
Tuesday, February 11 \| 5:00PM - 7:00PM Unusual Elements and Reactions Room: Mesa A-B Speaker 1 of 4 * George Chaconas, University of Calgary, Canada Telomere Resolution in the Lyme Disease Spirochete: Mechanistic Similarities to Site-Specific Recombination and DNA Transposition
Tuesday, February 11 \| 5:00PM - 7:00PM Unusual Elements and Reactions Room: Mesa A-B Speaker 2 of 4 Alan M. Lambowitz, University of Texas at Austin, USA Group II Intron Mobility by Reverse Splicing into DNA and its Applications in Targeted Gene Disruption and Site-Specific DNA Insertion
Tuesday, February 11 \| 5:00PM - 7:00PM Unusual Elements and Reactions Room: Mesa A-B Speaker 3 of 4 Marlene Belfort, University of Albany, SUNY, USA Mobile Introns: Function and Evolution
Tuesday, February 11 \| 5:00PM - 7:00PM Unusual Elements and Reactions Room: Mesa A-B Speaker 4 of 4 Russell T.M. Poulter, University of Otago, New Zealand Short Talk: A Mini-Intein in Cryptococcus
Tuesday, February 11 \| 7:00PM - 8:00PM Social Hour Room: Mesa C
Tuesday, February 11 \| 8:00PM - 10:00PM Poster Session 3: Recombination in Development, Homing and U nusual Reactions Room: Mesa C
Wednesday, February 12 \| 7:00AM - 8:00AM Breakfast Room: Chamisa
Wednesday, February 12 \| 8:00AM - 11:00AM Developmentally Programmed Rearrangements Room: Mesa A-B Speaker 1 of 5 * Martin Gellert, NIDDK, National Institutes of Health, USA Multiple Roles of the Rag Proteins in Recombination and Transposition
Wednesday, February 12 \| 8:00AM - 11:00AM Developmentally Programmed Rearrangements Room: Mesa A-B Speaker 2 of 5 Meng-Chao Yao, Fred Hutchinson Cancer Research Center, USA Programmed Genome Rearrangements in Tetrahymena: An RNA-Guided System of Genome Defense
Wednesday, February 12 \| 8:00AM - 11:00AM Developmentally Programmed Rearrangements Room: Mesa A-B Speaker 3 of 5 Zsuzsanna Izsvak, Max-Delbrück Center, Germany Short Talk: NHEJ Factors and ATM are both Required for Healing the Wounds Inflicted by Sleeping Beauty Transposition in Mammalian Cells
Wednesday, February 12 \| 8:00AM - 11:00AM Developmentally Programmed Rearrangements Room: Mesa A-B Speaker 4 of 5 Koichi Kawakami, National Institute of Genetics, Japan Short Talk: Transposition of the Tol2 Element of the Japanese Medaka Fish Oryzias latipes in Vertebrates
Wednesday, February 12 \| 8:00AM - 11:00AM Developmentally Programmed Rearrangements Room: Mesa A-B Speaker 5 of 5 Lindsay Grey Cowell, Duke University Medical Center, USA Short Talk: Phylogenetic Conservation of Recombination Signals Flanking Rag-1 and Rag-2
Wednesday, February 12 \| 9:20AM - 9:40AM Coffee Break Room: Promenade
Wednesday, February 12 \| 11:00AM - 1:00PM Poster Setup Room: Mesa C
Wednesday, February 12 \| 1:00PM - 10:00PM Poster Viewing Room: Mesa C
Wednesday, February 12 \| 4:30PM - 5:00PM Coffee & Snacks Available Room: Promenade
Wednesday, February 12 \| 5:00PM - 7:00PM Transposon Functions and Consequences Room: Mesa A-B Speaker 1 of 4 * William R. Engels, University of Wisconsin-Madison, USA Double-Strand Break Repair in Drosophila
Wednesday, February 12 \| 5:00PM - 7:00PM Transposon Functions and Consequences Room: Mesa A-B Speaker 2 of 4 Mary-Lou Pardue, Massachusetts Institute of Technology, USA Fitting into the Establishment: The Two Drosophila Telomeric Retrotransposons
Wednesday, February 12 \| 5:00PM - 7:00PM Transposon Functions and Consequences Room: Mesa A-B Speaker 3 of 4 Zoltan Ivics, Paul Ehrlich Institute, Germany Sleeping Beauty: Evolution, Regulation and Genetic Applications in Vertebrates
Wednesday, February 12 \| 5:00PM - 7:00PM Transposon Functions and Consequences Room: Mesa A-B Speaker 4 of 4 Thomas Peterson, Iowa State University, USA Short Talk: Transposition of Reversed Ac Element Ends Shuffles Exons and Rearranges Chromosomes in Maize
Wednesday, February 12 \| 7:00PM - 8:00PM Social Hour Room: Mesa C
Wednesday, February 12 \| 8:00PM - 10:00PM Poster Session 4: Genomes and Evolution Room: Mesa C
Thursday, February 13 \| 7:00AM - 8:00AM Breakfast Room: Chamisa
Thursday, February 13 \| 8:00AM - 11:15AM Host-Transposon Communication and Regulation Room: Mesa A-B Speaker 1 of 6 * Daniel F. Voytas, University of Minnesota, USA Retrotransposition and Heterochromatin in Baker’s Yeast
Thursday, February 13 \| 8:00AM - 11:15AM Host-Transposon Communication and Regulation Room: Mesa A-B Speaker 2 of 6 Reinhard Kunze, University of Cologne, Germany The Maize Ac/Ds Transposable Elements: Regulation and Manipulation of Transposition Activity
Thursday, February 13 \| 8:00AM - 11:15AM Host-Transposon Communication and Regulation Room: Mesa A-B Speaker 3 of 6 Donald Rio, University of California, Berkeley, USA Mechanism and Regulation of Drosophila P Element Transposition
Thursday, February 13 \| 8:00AM - 11:15AM Host-Transposon Communication and Regulation Room: Mesa A-B Speaker 4 of 6 M. Joan Curcio, Wadsworth Center, USA Activation of LTR-Retrotransposons in Telomerase-Negative Yeast Mutants
Thursday, February 13 \| 8:00AM - 11:15AM Host-Transposon Communication and Regulation Room: Mesa A-B Speaker 5 of 6 Scott E. Devine, Emory University School of Medicine, USA Short Talk: Functional Genomics Reveals Relationships between the Retrovirus-Like Ty1 Element and its Host
Thursday, February 13 \| 8:00AM - 11:15AM Host-Transposon Communication and Regulation Room: Mesa A-B Speaker 6 of 6 Ping Zhang, University of Connecticut, USA Short Talk: Timing and Targeting of P-Element Local Transposition in the Male Germ Line Cells of Drosophila melanogaster
Thursday, February 13 \| 9:20AM - 9:40AM Coffee Break Room: Promenade
Thursday, February 13 \| 4:30PM - 5:00PM Coffee & Snacks Available Room: Promenade
Thursday, February 13 \| 5:00PM - 7:00PM Transposons and Genome Organization Room: Mesa A-B Speaker 1 of 5 * Haig H. Kazazian, Johns Hopkins University School of Medicine, USA Further Estimates of the Frequency of Retrotransposition Events in Humans
Thursday, February 13 \| 5:00PM - 7:00PM Transposons and Genome Organization Room: Mesa A-B Speaker 2 of 5 Susan R. Wessler, University of California, Riverside, USA Rice as a Model System to Understand the Origin and Spread of MITEs
Thursday, February 13 \| 5:00PM - 7:00PM Transposons and Genome Organization Room: Mesa A-B Speaker 3 of 5 Dixie L. Mager, British Columbia Cancer Agency, Canada Short Talk: ETn Retrotransposons and Related Type D Endogenous Retroviral Elements in the Mouse
Thursday, February 13 \| 5:00PM - 7:00PM Transposons and Genome Organization Room: Mesa A-B Speaker 4 of 5 Hugh M. Robertson, University of Illinois at Urbana-Champaign, USA Short Talk: Molecular Evolution of Eeyore/TIGD1 and Nine Other Human Genes Derived from Tigger/pogo DNA Transposons
Thursday, February 13 \| 5:00PM - 7:00PM Transposons and Genome Organization Room: Mesa A-B Speaker 5 of 5 Zhijian (Jake) Tu, Virginia Polytechnic Institute and State University, USA Short Talk: Mosquito Transposable Elements: A Genomic and Evolutionary Perspective
Thursday, February 13 \| 7:00PM - 8:00PM Social Hour Room: Mesa C
Thursday, February 13 \| 8:00PM - 11:00PM Entertainment Room: Mesa C
Thursday, February 13 \| 8:00PM - 11:00PM Cash Bar Room: Mesa C
Friday, February 14 \| 10:26AM - 10:26AM Departure *Session Chair.