Web Desc
Optical Imaging: Applications to Biology and Medicine
Organizer(s): Dorothea Becker, Scott E. Fraser and Daniel L. Farkas
Date: February 11 - 16, 2003
Location: Taos Convention Center (meeting only), Taos, New Mexico, USA
Sponsored in part by The Director's Sponsor Fund
For important information on the coronavirus, please click here
Summary of Meeting:
Recent advances in optical imaging have opened new avenues for dynamically visualizing, recording, and quantitating in living systems, genetic, developmental, and physiologic changes that cannot be captured by conventional light microscopy or traditional medical imaging methods. In cellular and developmental biology, neuroscience, malignant and non-malignant human diseases, and tissue engineering, it has become increasingly clear that new approaches have to be pursued to gain insights into complex patterns of gene expression, regulation, and interaction to better understand mechanisms. Given its features (spatial, temporal and intensity range, wavelength, polarization, and coherence), light is well suited to study in vivo and in real time, complex or systemic processes that cannot be addressed in vitro. By combining molecular specificity, gene targeting, and advanced optical imaging, it has become possible to study development, gene functions, and disease processes in living animal models. In addition to real-time, tomographic 3-D fluorescence and diffuse optical imaging, techniques such as confocal and multi-photon scanning fluorescence microscopy, bioluminescence, spectral imaging and optical coherence tomography are beginning to find their way into the clinic as noninvasive diagnostic tools for early detection and improved monitoring of disease. The overall objective of the symposium is to demonstrate how newly developed modalities in optical imaging can be used to address central biological questions with high specificity and spatio-temporal resolution. Rather than focusing merely on technological issues, the symposium will present the science that motivated and benefited from a given technical advance. This tight coupling will allow the participants to fully appreciate both the costs and benefits of each approach. In addition, the symposium will bring together acknowledged leaders in the field of optical imaging with scientists and clinicians with relevant research problems in order to foster collaborations that will lead to novel interdisciplinary approaches to biological and medical questions. By reviewing exciting new developments in advanced optical imaging, the symposium will serve as a forum to demonstrate its present and future applications to important areas of science and medicine, and define future directions in these areas.
Discounted Abstract Deadline: October 10 2002
Discounted Registration Deadline: December 11 2002
We gratefully acknowledge additional support for this conference from:
Carl Zeiss MicroImaging, Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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Program

Tuesday, February 11 | 3:00PM - 7:00PM
Registration
Room: Rio Grande Hall D


Tuesday, February 11 | 6:15PM - 7:15PM
Welcome
Room: Bataan Hall


Tuesday, February 11 | 7:15PM - 7:30PM
Orientation
Room: Rio Grande Hall A-B


Tuesday, February 11 | 7:30PM - 8:30PM
Keynote Address
Room: Rio Grande Hall A-B

Speaker 1 of 1
Roger Y. Tsien, HHMI/University of California, San Diego, USA
Imaging Signal Transduction and Protein Sociology

Wednesday, February 12 | 7:00AM - 8:00AM
Breakfast
Room: Bataan


Wednesday, February 12 | 8:00AM - 11:00AM
Optical Imaging in Biology: Concepts, Goals and Approaches
Room: Rio Grande Hall C-D

Speaker 1 of 5
Toshio Yanagida, Osaka University Graduate School of Frontier Biosciences, Japan
Towards Nano-Bioscience: Optical Imaging of Molecular Machines

Wednesday, February 12 | 8:00AM - 11:00AM
Optical Imaging in Biology: Concepts, Goals and Approaches
Room: Rio Grande Hall C-D

Speaker 2 of 5
Robert H. Singer, Albert Einstein College of Medicine, USA
Single Cell Gene Expression Profiling

Wednesday, February 12 | 8:00AM - 11:00AM
Optical Imaging in Biology: Concepts, Goals and Approaches
Room: Rio Grande Hall C-D

Speaker 3 of 5
David R. Walt, Tufts University, USA
High-Density Optical Fiber Arrays for Cell-Based Sensing and Cell Selection

Wednesday, February 12 | 8:00AM - 11:00AM
Optical Imaging in Biology: Concepts, Goals and Approaches
Room: Rio Grande Hall C-D

Speaker 4 of 5
* Thomas M. Jovin, Max-Planck Institute for Biophysical Chemistry, Germany
New FRET Modalities for Studying Protein-Protein Association and Dynamics in Cellular Signal Transduction: Homotransfer (Energy Migration) FRET (emFRET) and Photochromic FRET (pcFRET)

Wednesday, February 12 | 8:00AM - 11:00AM
Optical Imaging in Biology: Concepts, Goals and Approaches
Room: Rio Grande Hall C-D

Speaker 5 of 5
Sanford M. Simon, Rockefeller University, USA
Visualizing Dynamics at the Cell Surface

Wednesday, February 12 | 9:20AM - 9:40AM
Coffee Break
Room: Bataan


Wednesday, February 12 | 11:00AM - 1:00PM
Poster Setup
Room: Rio Grande Hall A-B


Wednesday, February 12 | 1:00PM - 10:00PM
Poster Viewing
Room: Rio Grande Hall A-B


Wednesday, February 12 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Bataan


Wednesday, February 12 | 5:00PM - 7:00PM
In vivo Optical Imaging for Tumor Detection and Monitoring
Room: Rio Grande Hall C-D

Speaker 1 of 3
* Bruce Tromberg, University of California, Irvine, USA
Laser and Photon Propagation-Based Methods for Cancer Detection

Wednesday, February 12 | 5:00PM - 7:00PM
In vivo Optical Imaging for Tumor Detection and Monitoring
Room: Rio Grande Hall C-D

Speaker 2 of 3
Edward B. Brown, Massachusetts General Hospital, USA
Short Talk: Dynamic Imaging of Collagen in Tumors in vivo using Second Harmonic Generation

Wednesday, February 12 | 5:00PM - 7:00PM
In vivo Optical Imaging for Tumor Detection and Monitoring
Room: Rio Grande Hall C-D

Speaker 3 of 3
Tony Wyss-Coray, Stanford University School of Medicine, USA
Short Talk: Glutamate Receptor Agonist Causes Rapid Activation of a TGF-beta Reporter Gene in Brains of Transgenic Mice

Wednesday, February 12 | 7:00PM - 8:00PM
Social Hour
Room: Rio Grande Hall A-B


Wednesday, February 12 | 8:00PM - 10:00PM
Poster Session 1: Optical Imaging and Studies of Neoplasia
Room: Rio Grande Hall A-B


Thursday, February 13 | 7:00AM - 8:00AM
Breakfast
Room: Bataan


Thursday, February 13 | 8:00AM - 11:00AM
Optical Imaging in Stem Cell Research and Tissue Engineering
Room: Rio Grande Hall C-D

Speaker 1 of 4
* David J. Mooney, Harvard University, USA
Materials to Regulate Tissue Regeneration

Thursday, February 13 | 8:00AM - 11:00AM
Optical Imaging in Stem Cell Research and Tissue Engineering
Room: Rio Grande Hall C-D

Speaker 2 of 4
Johnny Huard, University of Pittsburgh, USA
Gene Therapy and Tissue Engineering Based on Muscle Derived Stem Cells: Potential for Musculoskeletal Tissue Regeneration & Repair



Thursday, February 13 | 8:00AM - 11:00AM
Optical Imaging in Stem Cell Research and Tissue Engineering
Room: Rio Grande Hall C-D

Speaker 3 of 4
Michael D. Cahalan, University of California, Irvine, USA
Two-Photon Imaging of Lymphocytes in vivo

Thursday, February 13 | 8:00AM - 11:00AM
Optical Imaging in Stem Cell Research and Tissue Engineering
Room: Rio Grande Hall C-D

Speaker 4 of 4
Kat Hadjantonakis, Sloan Kettering Institute, USA
Short Talk: Imaging Active Chromatin in Mouse Embryonic Stem Cells and Early Embryos

Thursday, February 13 | 9:20AM - 9:40AM
Coffee Break
Room: Bataan


Thursday, February 13 | 11:00AM - 1:00PM
Poster Setup
Room: Rio Grande Hall A-B


Thursday, February 13 | 1:00PM - 10:00PM
Poster Viewing
Room: Rio Grande Hall A-B


Thursday, February 13 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Bataan


Thursday, February 13 | 5:00PM - 7:00PM
Optical Imaging in Gene Therapy and Regenerative Medicine
Room: Rio Grande Hall C-D

Speaker 1 of 4
William F. Pralong, Swiss Federal Institute of Technology Lausanne (EPFL), Switzerland
Imaging CNS Gene Therapy

Thursday, February 13 | 5:00PM - 7:00PM
Optical Imaging in Gene Therapy and Regenerative Medicine
Room: Rio Grande Hall C-D

Speaker 2 of 4
Christopher H. Contag, Institute for Quantitative Health Sciences and Engineering, USA
Optical Imaging for Visualizing Gene Expression in Living Animals

Thursday, February 13 | 5:00PM - 7:00PM
Optical Imaging in Gene Therapy and Regenerative Medicine
Room: Rio Grande Hall C-D

Speaker 3 of 4
* Daniel L. Farkas, Cedars-Sinai Medical Center, USA
Optical Bioimaging for Regenerative Medicine

Thursday, February 13 | 5:00PM - 7:00PM
Optical Imaging in Gene Therapy and Regenerative Medicine
Room: Rio Grande Hall C-D

Speaker 4 of 4
Yusuke Ohba, Research Institute for Microbial Diseases, Osaka University, Japan
Short Talk: Mechanism of the Spatio-Temporal Regulation of Ras and Rap1

Thursday, February 13 | 7:00PM - 8:00PM
Social Hour
Room: Rio Grande Hall A-B


Thursday, February 13 | 8:00PM - 10:00PM
Poster Session 2: Optical Imaging in Stem Cell Research and
Tissue Engineering
Room: Rio Grande Hall A-B


Friday, February 14 | 7:00AM - 8:00AM
Breakfast
Room: Bataan


Friday, February 14 | 8:00AM - 11:00AM
Optical Imaging of Neurons: From Molecules to Circuits
Room: Rio Grande Hall C-D

Speaker 1 of 5
Ehud Isacoff, University of California, Berkeley, USA
Genetically-Encoded Sensors for Optical Imaging of Electrical Activity

Friday, February 14 | 8:00AM - 11:00AM
Optical Imaging of Neurons: From Molecules to Circuits
Room: Rio Grande Hall C-D

Speaker 2 of 5
Timothy A. Ryan, Weill Medical College of Cornell University, USA
Dissecting Synaptic Function with Optical Methods

Friday, February 14 | 8:00AM - 11:00AM
Optical Imaging of Neurons: From Molecules to Circuits
Room: Rio Grande Hall C-D

Speaker 3 of 5
* Lawrence Katz, Duke University Medical Center, USA
Imaging Functional Architecture in the Mammalian Olfactory Bulb

Friday, February 14 | 8:00AM - 11:00AM
Optical Imaging of Neurons: From Molecules to Circuits
Room: Rio Grande Hall C-D

Speaker 4 of 5
Jeff W. Lichtman, Harvard University, USA
Monitoring Synapses in Living Animals

Friday, February 14 | 8:00AM - 11:00AM
Optical Imaging of Neurons: From Molecules to Circuits
Room: Rio Grande Hall C-D

Speaker 5 of 5
Romesh A. Draviam, University of Pittsburgh School of Medicine, USA
Short Talk: Analysis of Dystrophin Associated Proteins in Whole Adult Mouse Muscle Using Single Photon and Multiphoton Confocal Microscopy

Friday, February 14 | 9:20AM - 9:40AM
Coffee Break
Room: Bataan


Friday, February 14 | 11:00AM - 1:00PM
Poster Setup
Room: Rio Grande Hall A-B


Friday, February 14 | 1:00PM - 10:00PM
Poster Viewing
Room: Rio Grande Hall A-B


Friday, February 14 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Bataan


Friday, February 14 | 5:00PM - 7:00PM
Multimodal Imaging of Neural Development
Room: Rio Grande Hall C-D

Speaker 1 of 4
Amiram Grinvald, Optical Imaging Ltd., Israel
Visualization of Cortical Dynamics

Friday, February 14 | 5:00PM - 7:00PM
Multimodal Imaging of Neural Development
Room: Rio Grande Hall C-D

Speaker 2 of 4
* Scott E. Fraser, University of Southern California, USA
Multi-Photon, Multispectral-Spectral Imaging of Neural Development

Friday, February 14 | 5:00PM - 7:00PM
Multimodal Imaging of Neural Development
Room: Rio Grande Hall C-D

Speaker 3 of 4
Arthur W. Toga, University of California, Los Angeles, USA
Multidimensional Brain Image Database

Friday, February 14 | 5:00PM - 7:00PM
Multimodal Imaging of Neural Development
Room: Rio Grande Hall C-D

Speaker 4 of 4
Yukihiro Hirose, Kyoto University, Japan
Short Talk: Single Cell Fate Analysis in Early Neural Development of Medaka and its Presentation using 3-D Computer Graphics

Friday, February 14 | 7:00PM - 8:00PM
Social Hour
Room: Rio Grande Hall A-B


Friday, February 14 | 8:00PM - 10:00PM
Poster Session 3: Optical Imaging in Neurobiology
Room: Rio Grande Hall A-B


Saturday, February 15 | 7:00AM - 8:00AM
Breakfast
Room: Bataan


Saturday, February 15 | 8:00AM - 11:00AM
Optical Imaging of Angiogenesis and Microcirculation
Room: Rio Grande Hall C-D

Speaker 1 of 5
* Dorothea Becker, University of Pittsburgh, USA
Spectral and Fluorescence Imaging of Melanoma and Angiogenesis

Saturday, February 15 | 8:00AM - 11:00AM
Optical Imaging of Angiogenesis and Microcirculation
Room: Rio Grande Hall C-D

Speaker 2 of 5
Rox Anderson, Massachusetts General Hospital, USA
Confocal and Vital Microscopy of Skin

Saturday, February 15 | 8:00AM - 11:00AM
Optical Imaging of Angiogenesis and Microcirculation
Room: Rio Grande Hall C-D

Speaker 3 of 5
Elizabeth A.V. Jones, McGill University, Canada
Short Talk: In vivo Imaging and Quantification of Microvascular Blood Flow during Mammalian Development

Saturday, February 15 | 8:00AM - 11:00AM
Optical Imaging of Angiogenesis and Microcirculation
Room: Rio Grande Hall C-D

Speaker 4 of 5
Thomas M. Jovin, Max-Planck Institute for Biophysical Chemistry, Germany
and

Saturday, February 15 | 8:00AM - 11:00AM
Optical Imaging of Angiogenesis and Microcirculation
Room: Rio Grande Hall C-D

Speaker 5 of 5
Sanford M. Simon, Rockefeller University, USA
Short Talk: Quantum Dots

Saturday, February 15 | 9:20AM - 9:40AM
Coffee Break
Room: Bataan


Saturday, February 15 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Bataan


Saturday, February 15 | 5:00PM - 7:00PM
Emerging Methodologies of Optical Bioimaging and Interventio
n

Room: Rio Grande Hall C-D

Speaker 1 of 4
* Martin Lee Chalfie, Columbia University, USA
GFP: Shedding Light on Biological Processes

Saturday, February 15 | 5:00PM - 7:00PM
Emerging Methodologies of Optical Bioimaging and Interventio
n

Room: Rio Grande Hall C-D

Speaker 2 of 4
Warren S. Grundfest, University of California, Los Angeles, USA
Time-Resolved Fluorescence Spectroscopy for the Detection of Unstable Atherosclerotic Lesions

Saturday, February 15 | 5:00PM - 7:00PM
Emerging Methodologies of Optical Bioimaging and Interventio
n

Room: Rio Grande Hall C-D

Speaker 3 of 4
James G. Fujimoto, Massachusetts Institute of Technology, USA
Optical Coherence Tomography Imaging for in vivo Imaging

Saturday, February 15 | 5:00PM - 7:00PM
Emerging Methodologies of Optical Bioimaging and Interventio
n

Room: Rio Grande Hall C-D

Speaker 4 of 4
Stefanie J. Mandl, BN-Immunotherapeutics, USA
Short Talk: Non-Invasive Assessment of the Degree of Apoptosis and Tumor Cell Loss Observed by 99mTc-Annexin V Micro Single Photon Emission Computed Tomography (mSPECT) and in vivo Bioluminescent Imaging (BLI) Following a Single Dose of Chemotherapy

Saturday, February 15 | 7:00PM - 8:00PM
Social Hour
Room: Bataan


Saturday, February 15 | 8:00PM - 11:00PM
Entertainment
Room: Bataan


Saturday, February 15 | 8:00PM - 11:00PM
Cash Bar
Room: Bataan


Sunday, February 16 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.