Molecular and Cellular Basis of Septic Shock

Organizer(s): Richard Bucala, Seamas Donnelly and Barbara Sherry

Supported by Keystone Symposia

Summary of Meeting:

Despite important advances in our ability to diagnose and treat infectious diseases, the mortality attributed to septic shock - the most severe complication of infection - remains a significant medical problem. The last several years have witnessed important advances in our understanding of host-pathogen interactions, particularly in the areas of inflammatory cell interaction with gram-positive and gram-negative bacteria, endotoxin recognition and signaling, and genetic differences in susceptibility to septic complications. Important new mediators of sepsis, and novel mechanisms of host cell toxicity such as apoptosis also have been identified. This information, together with data from recently completed clinical trials targeting pathways considered central to sepsis pathogenesis, provide an important foundation for defining the molecular and cellular basis of sepsis and formulating new strategies for intervention. The goal of this Keystone symposium will be to integrate this new information into an interdisciplinary approach toward understanding sepsis pathogenesis.

Discounted Abstract Deadline: November 7 2002

Discounted Registration Deadline: January 7 2003

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