Web Desc
Molecular and Cellular Basis of Septic Shock
Organizer(s): Richard Bucala, Seamas Donnelly and Barbara Sherry
Date: March 07 - 11, 2003
Location: Granlibakken Tahoe, Tahoe City, CA, USA
Supported by Keystone Symposia
Summary of Meeting:
Despite important advances in our ability to diagnose and treat infectious diseases, the mortality attributed to septic shock - the most severe complication of infection - remains a significant medical problem. The last several years have witnessed important advances in our understanding of host-pathogen interactions, particularly in the areas of inflammatory cell interaction with gram-positive and gram-negative bacteria, endotoxin recognition and signaling, and genetic differences in susceptibility to septic complications. Important new mediators of sepsis, and novel mechanisms of host cell toxicity such as apoptosis also have been identified. This information, together with data from recently completed clinical trials targeting pathways considered central to sepsis pathogenesis, provide an important foundation for defining the molecular and cellular basis of sepsis and formulating new strategies for intervention. The goal of this Keystone symposium will be to integrate this new information into an interdisciplinary approach toward understanding sepsis pathogenesis.
Discounted Abstract Deadline: November 7 2002
Discounted Registration Deadline: January 7 2003
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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Program

Friday, March 07 | 3:00PM - 7:00PM
Registration
Room: Pre-Function


Friday, March 07 | 7:15PM - 7:30PM
Orientation
Room: Mountain/Lake Rooms


Friday, March 07 | 7:30PM - 8:30PM
Keynote Address
Room: Mountain/Lake Rooms

Speaker 2 of 2
Edward Abraham, University of Alabama at Birmingham, USA
Sepsis: Definitions, Epidemiology and Therapeutic Approaches

Friday, March 07 | 7:30PM - 8:30PM
Keynote Address
Room: Mountain/Lake Rooms

Speaker 1 of 2
* Richard J. Bucala, Yale University School of Medicine, USA

Saturday, March 08 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Saturday, March 08 | 8:00AM - 11:00AM
Overview of Sepsis and Multi-Organ Failure
Room: Mountain/Lake Rooms

Speaker 6 of 6
† Mark M. Wurfel, University of Washington, USA
Short Talk: Patterns of Inter-Individual Variation in Inflammatory Responses to Lipopolysaccharide Revealed by Gene Expression Arrays

Saturday, March 08 | 8:00AM - 11:00AM
Overview of Sepsis and Multi-Organ Failure
Room: Mountain/Lake Rooms

Speaker 5 of 6
Claudia Farias Benjamim, Biomedical of Science, Brazil
Short Talk: Septic Mice Fail to Mount an Appropriate Innate Immune Response during Secondary Infection by Aspergillus fumigatus

Saturday, March 08 | 8:00AM - 11:00AM
Overview of Sepsis and Multi-Organ Failure
Room: Mountain/Lake Rooms

Speaker 4 of 6
Thomas J. Murphy, Ireland
Short Talk: A Central Role for CD4+ T-Cells in Regulating the Pro-Inflammatory Response to TLR Agonists after Injury

Saturday, March 08 | 8:00AM - 11:00AM
Overview of Sepsis and Multi-Organ Failure
Room: Mountain/Lake Rooms

Speaker 3 of 6
Thierry F. Calandra, Centre Hospitalier Universitaire Vaudois, Switzerland
Macrophage Migration Inhibitory Factor (MIF) Regulation of Innate Immunity

Saturday, March 08 | 8:00AM - 11:00AM
Overview of Sepsis and Multi-Organ Failure
Room: Mountain/Lake Rooms

Speaker 2 of 6
Jonathan Cohen, University of Brighton, UK
Sepsis in the Immuno-Compromised Host

Saturday, March 08 | 8:00AM - 11:00AM
Overview of Sepsis and Multi-Organ Failure
Room: Mountain/Lake Rooms

Speaker 1 of 6
* Seamas C. Donnelly, University College Dublin, Ireland
Acute Respiratory Distress Syndrome (ARDS) and Multiple Organ Failure Syndrome (MOFS)

Saturday, March 08 | 9:20AM - 9:40AM
Coffee Break
Room: Pre-Function


Saturday, March 08 | 11:00AM - 1:00PM
Poster Setup
Room: Bay Room


Saturday, March 08 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay Room


Saturday, March 08 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Pre-Function


Saturday, March 08 | 5:00PM - 7:00PM
Biology of the Innate Immune Response
Room: Mountain/Lake Rooms

Speaker 3 of 3
Donald N. Cook, NIEHS, National Institutes of Health, USA
A Genetic Analysis of the Innate Immune Response to Endotoxin

Saturday, March 08 | 5:00PM - 7:00PM
Biology of the Innate Immune Response
Room: Mountain/Lake Rooms

Speaker 2 of 3
Daniel G. Remick, University of Michigan Medical School, USA
Heterogeneity of the Septic Inflammatory Response

Saturday, March 08 | 5:00PM - 7:00PM
Biology of the Innate Immune Response
Room: Mountain/Lake Rooms

Speaker 1 of 3
* Jules A. Hoffmann, Institute of Cellular and Molecular Biology, France
Drosophila Immunity

Saturday, March 08 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Saturday, March 08 | 8:00PM - 10:00PM
Poster Session 1
Room: Bay Room


Saturday, March 08 | 8:00PM - 9:00PM
Social Hour
Room: Bay Room


Sunday, March 09 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Sunday, March 09 | 8:00AM - 11:00AM
Microbial and Molecular Pathogenesis of Sepsis
Room: Mountain/Lake Rooms

Speaker 2 of 4
* Richard A. Flavell, HHMI/Yale University School of Medicine, USA
Cell Signaling Pathways in Innate Immunity

Sunday, March 09 | 8:00AM - 11:00AM
Microbial and Molecular Pathogenesis of Sepsis
Room: Mountain/Lake Rooms

Speaker 1 of 4
Adrian V. S. Hill, Jenner Institute, University of Oxford, UK
Immunogenetics and Susceptibility to Infectious Diseases

Sunday, March 09 | 8:00AM - 11:00AM
Microbial and Molecular Pathogenesis of Sepsis
Room: Mountain/Lake Rooms

Speaker 3 of 4
Alice Prince, Columbia University, USA
Bacterial Interactions with Pulmonary Epithelium

Sunday, March 09 | 8:00AM - 11:00AM
Microbial and Molecular Pathogenesis of Sepsis
Room: Mountain/Lake Rooms

Speaker 4 of 4
Paul W. Noble, Yale University School of Medicine, USA
Role of CD44 in the Resolution of Lung Inflammation

Sunday, March 09 | 9:20AM - 9:40AM
Coffee Break
Room: Pre-Function


Sunday, March 09 | 11:00AM - 1:00PM
Poster Setup
Room: Bay Room


Sunday, March 09 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay Room


Sunday, March 09 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Pre-Function


Sunday, March 09 | 5:00PM - 7:00PM
Downstream Effects of Microbial Invasion
Room: Mountain/Lake Rooms

Speaker 1 of 3
* Peter A. Ward, University of Michigan Medical School, USA
Role of C5a and C5aR in Sepsis

Sunday, March 09 | 5:00PM - 7:00PM
Downstream Effects of Microbial Invasion
Room: Mountain/Lake Rooms

Speaker 2 of 3
Adriano Giorgio Rossi, University of Edinburgh, UK
Apoptosis and the Resolution of Inflammation

Sunday, March 09 | 5:00PM - 7:00PM
Downstream Effects of Microbial Invasion
Room: Mountain/Lake Rooms

Speaker 3 of 3
Barbara Sherry, North Carolina State University, USA
Cell Trafficking Abnormalities in Sepsis

Sunday, March 09 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Sunday, March 09 | 8:00PM - 9:00PM
Social Hour
Room: Bay Room


Sunday, March 09 | 8:00PM - 10:00PM
Poster Session 2
Room: Bay Room


Monday, March 10 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Monday, March 10 | 8:00AM - 11:00AM
Regulatory Pathways of the Systemic Inflammatory Response
Room: Mountain/Lake Rooms

Speaker 1 of 4
* Richard J. Bucala, Yale University School of Medicine, USA

Monday, March 10 | 8:00AM - 11:00AM
Regulatory Pathways of the Systemic Inflammatory Response
Room: Mountain/Lake Rooms

Speaker 2 of 4
Joost J. Oppenheim, National Institutes of Health, USA
Many Chemokines and Defensins Exhibit Antimicrobial as well as Immunoadjuvant Activities

Monday, March 10 | 8:00AM - 11:00AM
Regulatory Pathways of the Systemic Inflammatory Response
Room: Mountain/Lake Rooms

Speaker 3 of 4
Akihiko Yoshimura, Keio University, Japan
Suppression of TLR Signaling and Inflammation by SOCS Family Proteins

Monday, March 10 | 8:00AM - 11:00AM
Regulatory Pathways of the Systemic Inflammatory Response
Room: Mountain/Lake Rooms

Speaker 4 of 4
Kevin J. Tracey, Feinstein Institute for Medical Research, USA
Systemic Inflammation and Nerve Stimulators: From TNF to HMGB-1

Monday, March 10 | 9:00AM - 12:00PM
Entertainment
Room: Granhall


Monday, March 10 | 9:00AM - 12:00PM
Cash Bar
Room: Granhall


Monday, March 10 | 9:20AM - 9:40AM
Coffee Break
Room: Pre-Function


Monday, March 10 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Pre-Function


Monday, March 10 | 5:00PM - 7:00PM
Therapeutic Intervention in Septic Shock
Room: Mountain/Lake Rooms

Speaker 1 of 4
* Barbara Sherry, North Carolina State University, USA

Monday, March 10 | 5:00PM - 7:00PM
Therapeutic Intervention in Septic Shock
Room: Mountain/Lake Rooms

Speaker 2 of 4
Richard J. Bucala, Yale University School of Medicine, USA
Mif Alleles and the Genetic Basis for Macrophage Responsiveness

Monday, March 10 | 5:00PM - 7:00PM
Therapeutic Intervention in Septic Shock
Room: Mountain/Lake Rooms

Speaker 3 of 4
Charles T. Esmon, Oklahoma Medical Research Foundation, USA
Protein C Pathways Critical for Septic Shock

Monday, March 10 | 5:00PM - 7:00PM
Therapeutic Intervention in Septic Shock
Room: Mountain/Lake Rooms

Speaker 4 of 4
Fletcher B. Taylor Jr., Oklahoma Medical Research Foundation, USA
Some New Observations on the Pathophysiology of Primate E. coli Sepsis

Monday, March 10 | 7:00PM - 8:00PM
Social Hour
Room: Granhall


Monday, March 10 | 8:00PM - 9:00PM
Dinner
Room: Granhall


Tuesday, March 11 | 10:26AM - 10:26AM
Departure


*Session Chair.