The Enzymology of Chromatin and Transcription

Organizer(s): Shelley L. Berger and Jerry L. Workman

Supported by Keystone Symposia

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Summary of Meeting:

Enzymes have a direct role in transcriptional regulation. Enzymes that affect chromatin structure and function alter the template and so regulate transcription. In addition, the transcriptional machinery itself contains enzymes that carry out and regulate RNA synthesis. It is critical to determine how these different levels of regulation work together to alter gene expression. One major issue in transcription is the function of two major enzyme classes that affect chromatin: the histone modifiers and the ATP-dependent remodelers. The overarching question is how these two classes of chromatin enzymes work together to influence the basal transcriptional machinery to ultimately regulate genes. The meeting goals are to discuss functions of chromatin modification and remodeling enzymes, mechanisms involved in transcriptional initiation/elongation, and finally, how alteration of chromatin translates into regulation of basal transcription. The program will bring together experts in chromatin and transcriptional regulation to focus on the intersection between these areas.

Discounted Abstract Deadline: November 11 2002

Discounted Registration Deadline: January 10 2003

We gratefully acknowledge additional support for this conference from:

We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1 R13 CA099198-01

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