Web Desc
Eicosanoid Lipid Mediators: From Molecular Discovery to Clinical Application
Organizer(s): Jilly F. Evans, Colin D. Funk and Takao Shimizu
Date: March 11 - 16, 2003
Location: Granlibakken Tahoe, Tahoe City, CA, USA
Sponsored by Aventis Pharmaceuticals, Inc.
Summary of Meeting:
Recent advances in the cloning and molecular characterization of eicosanoid pathway enzymes and receptors have provided both new structural, functional and genetic information and novel therapeutic targets. Eicosanoid pathway inhibitors (notably COX-2 inhibitors) and antagonists (notably CysLT1 receptor antagonists) have already found important places in the therapies of arthritis, pain and asthma. Novel applications for eicosanoid pathway modulators include other inflammatory and allergic diseases and cancer. The goal of the Keystone meeting in 2003 will be to combine state-of-the-art basic biology, including biochemistry, pharmacology and structural and genetic biology, with application of this knowledge to human therapeutics. This meeting will encourage scientific networking amongst different academic disciplines and industrial speakers in an informal and friendly atmosphere conducive to sharing latest data and building further collaborations. The key organizer is a woman and there will be a strong representation of women and minority speakers and interactive talks, eicosanoid trivia quizzes, poster prizes and special social events to encourage maximum scientific and social interactions. Specific topics will include cyclooxygenase structure and function and clinical benefit of cyclooxygenase-2 inhibitors, prostaglandin receptor expression, function and disease targets, lipoxygenases and leukotriene receptor cell biology and genetics, and clinical applications of eicosanoid pathway modulators.
Discounted Abstract Deadline: November 11 2002
Discounted Registration Deadline: January 13 2003
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1 R13 AI053151-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, March 11 | 3:00PM - 7:00PM
Registration
Room: Pre-Function


Tuesday, March 11 | 7:15PM - 7:30PM
Orientation
Room: Mountain/Lake Rooms


Tuesday, March 11 | 7:30PM - 8:30PM
Keynote Address
Room: Mountain/Lake Rooms

Speaker 1 of 1
Peter C. Isakson, Abbott Bioresearch Center, USA
Pharmacology and Clinical Utility of Cyclooxygenase-2 Inhibitors

Wednesday, March 12 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Wednesday, March 12 | 8:00AM - 11:00AM
Cyclooxygenase Biochemistry and Cell Biology
Room: Mountain/Lake Rooms

Speaker 1 of 5
* Lawrence J. Marnett, Vanderbilt University School of Medicine, USA

Wednesday, March 12 | 8:00AM - 11:00AM
Cyclooxygenase Biochemistry and Cell Biology
Room: Mountain/Lake Rooms

Speaker 2 of 5
William L. Smith, University of Michigan, USA
Cyclooxygenase and Peroxidase Catalysis by Prostaglandin Endoperoxide H Synthases

Wednesday, March 12 | 8:00AM - 11:00AM
Cyclooxygenase Biochemistry and Cell Biology
Room: Mountain/Lake Rooms

Speaker 3 of 5
Paola Patrignani, G. D'Annunzio University, Italy
Cyclooxygenase Inhibition and Cardiovascular Disease

Wednesday, March 12 | 8:00AM - 11:00AM
Cyclooxygenase Biochemistry and Cell Biology
Room: Mountain/Lake Rooms

Speaker 4 of 5
Marc Pouliot, Université Laval, Canada
Cell Biology of COX-2 in Human Neutrophils:
Impact of Adenosine


Wednesday, March 12 | 8:00AM - 11:00AM
Cyclooxygenase Biochemistry and Cell Biology
Room: Mountain/Lake Rooms

Speaker 5 of 5
Raymond N. DuBois, Arizona State University, USA
COX-2 I and Cancer: Is There a Connection?

Wednesday, March 12 | 9:20AM - 9:40AM
Coffee Break
Room: Pre-Function


Wednesday, March 12 | 11:00AM - 1:00PM
Poster Setup
Room: Bay Room


Wednesday, March 12 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay Room


Wednesday, March 12 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Pre-Function


Wednesday, March 12 | 5:00PM - 7:00PM
Prostaglandin Receptors
Room: Mountain/Lake Rooms

Speaker 1 of 4
* Paola Patrignani, G. D'Annunzio University, Italy

Wednesday, March 12 | 5:00PM - 7:00PM
Prostaglandin Receptors
Room: Mountain/Lake Rooms

Speaker 2 of 4
Shuh Narumiya, Kyoto University, Japan
Prostanoid-Mediated Body Defense Mechanisms and Outcome of their Breakdown

Wednesday, March 12 | 5:00PM - 7:00PM
Prostaglandin Receptors
Room: Mountain/Lake Rooms

Speaker 3 of 4
Kathleen M. Metters, Merck Frosst Centre for Therapeutic Research, Canada
The Prostanoid DP Receptor as a Target for Respiratory Diseases

Wednesday, March 12 | 5:00PM - 7:00PM
Prostaglandin Receptors
Room: Mountain/Lake Rooms

Speaker 4 of 4
Hiroyuki Hirai, BioMedical Laboratories, Japan
CRTH2, a Novel Prostaglandin D2 Receptor

Wednesday, March 12 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Wednesday, March 12 | 8:00PM - 9:00PM
Social Hour
Room: Bay Room


Wednesday, March 12 | 8:00PM - 10:00PM
Poster Session 1
Room: Bay Room


Thursday, March 13 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Thursday, March 13 | 8:00AM - 11:00AM
Lipoxygenases and Leukotrienes
Room: Mountain/Lake Rooms

Speaker 1 of 5
* Jilly F. Evans, PharmAkea Therapeutics, USA

Thursday, March 13 | 8:00AM - 11:00AM
Lipoxygenases and Leukotrienes
Room: Mountain/Lake Rooms

Speaker 2 of 5
Olof Radmark, Karolinska Institute, Sweden
5-Lipoxygenase: Ca2+, Phosphorylation and Interacting Proteins

Thursday, March 13 | 8:00AM - 11:00AM
Lipoxygenases and Leukotrienes
Room: Mountain/Lake Rooms

Speaker 3 of 5
Roy J. Soberman, Harvard Medical School, USA
Assembly of the Macromolecular Leukotriene Biosynthetic Complex

Thursday, March 13 | 8:00AM - 11:00AM
Lipoxygenases and Leukotrienes
Room: Mountain/Lake Rooms

Speaker 4 of 5
Wonhwa Cho, University of Illinois at Chicago, USA
Interactions of Secretory PLA2, Cytosolic PLA2 and 5-Lipoxygenase in Leukotriene Biosynthesis

Thursday, March 13 | 8:00AM - 11:00AM
Lipoxygenases and Leukotrienes
Room: Mountain/Lake Rooms

Speaker 5 of 5
Alan R. Brash, Vanderbilt University Medical Center, USA
Short Talk: Epithelial Lipoxygenases and their Functioning

Thursday, March 13 | 9:20AM - 9:40AM
Coffee Break
Room: Pre-Function


Thursday, March 13 | 11:00AM - 1:00PM
Poster Setup
Room: Bay Room


Thursday, March 13 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay Room


Thursday, March 13 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Pre-Function


Thursday, March 13 | 5:00PM - 7:15PM
Prostaglandin and Leukotriene Synthases
Room: Mountain/Lake Rooms

Speaker 1 of 5
* Robert C. Murphy, University of Colorado Denver, USA

Thursday, March 13 | 5:00PM - 7:15PM
Prostaglandin and Leukotriene Synthases
Room: Mountain/Lake Rooms

Speaker 2 of 5
Per-Johan Jakobsson, Karolinska Institutet, Sweden
Microsomal Prostaglandin E synthase 1

Thursday, March 13 | 5:00PM - 7:15PM
Prostaglandin and Leukotriene Synthases
Room: Mountain/Lake Rooms

Speaker 3 of 5
Laurent Audoly, Pieris AG, Germany
PGE Synthase

Thursday, March 13 | 5:00PM - 7:15PM
Prostaglandin and Leukotriene Synthases
Room: Mountain/Lake Rooms

Speaker 4 of 5
Yoshihiro Urade, Osaka Bioscience Institute, Japan
Prostaglandin D Synthase: From X-Ray Crystallography to Gene Manipulation

Thursday, March 13 | 5:00PM - 7:15PM
Prostaglandin and Leukotriene Synthases
Room: Mountain/Lake Rooms

Speaker 5 of 5
K. Frank Austen, Harvard Medical School, USA
Leukotriene C4 Synthase

Thursday, March 13 | 7:15PM - 8:15PM
Theme Dinner
Room: Granhall
The Thursday night dinner will have a dress theme for those that wish to come as someone/something starting with the letter M, e.g. Mickey Mouse, Madonna, Michael Jackson, etc. There will be prizes for most original, most easy to identify and most colorful. The organizers hope you will wear your M theme clothing for a fun dinner.

Thursday, March 13 | 8:00PM - 9:00PM
Social Hour
Room: Bay Room


Thursday, March 13 | 8:00PM - 10:00PM
Poster Session 2
Room: Bay Room


Friday, March 14 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Friday, March 14 | 8:00AM - 11:00AM
Phospholipases
Room: Mountain/Lake Rooms

Speaker 1 of 5
* Colin D. Funk, Queen's University, Canada

Friday, March 14 | 8:00AM - 11:00AM
Phospholipases
Room: Mountain/Lake Rooms

Speaker 2 of 5
Gérard Lambeau, Centre National de la Recherche Scientifique, France
Molecular Diversity and Functional Properties of Secreted Phospholipases A2

Friday, March 14 | 8:00AM - 11:00AM
Phospholipases
Room: Mountain/Lake Rooms

Speaker 3 of 5
Christina C. Leslie, National Jewish Health, USA
The Cytosolic Phospholipase A2 Catalytic Domain Modulates Association and Residence Time at Golgi Membranes

Friday, March 14 | 8:00AM - 11:00AM
Phospholipases
Room: Mountain/Lake Rooms

Speaker 4 of 5
Michael H. Gelb, University of Washington, USA
Structure, Function and Cellular Behavior of Mammalian Phospholipases A2

Friday, March 14 | 8:00AM - 11:00AM
Phospholipases
Room: Mountain/Lake Rooms

Speaker 5 of 5
Takao Shimizu, University of Tokyo, Japan
Roles of Cytosolic Phospholipase A2 and Related Molecules in vivo

Friday, March 14 | 9:20AM - 9:40AM
Coffee Break
Room: Pre-Function


Friday, March 14 | 11:30AM - 1:00PM
BBQ Lunch
Room: Granhall


Friday, March 14 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Pre-Function


Friday, March 14 | 5:00PM - 7:00PM
Novel Eicosanoids
Room: Mountain/Lake Rooms

Speaker 1 of 4
* Roy J. Soberman, Harvard Medical School, USA

Friday, March 14 | 5:00PM - 7:00PM
Novel Eicosanoids
Room: Mountain/Lake Rooms

Speaker 2 of 4
Lawrence J. Marnett, Vanderbilt University School of Medicine, USA
Endocannabinoid PG's and HETE's

Friday, March 14 | 5:00PM - 7:00PM
Novel Eicosanoids
Room: Mountain/Lake Rooms

Speaker 3 of 4
Robert C. Murphy, University of Colorado Denver, USA
Covalent Binding of Leukotriene A4 to DNA and RNA

Friday, March 14 | 5:00PM - 7:00PM
Novel Eicosanoids
Room: Mountain/Lake Rooms

Speaker 4 of 4
Giancarlo Folco, University of Milano, Italy
Transcellular Synthesis of Leukotrienes: The Dangerous Liaisons between Neutrophils and Endothelial Cells in Cardiac and Cerebral Vasculature


Friday, March 14 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Friday, March 14 | 8:00PM - 10:00PM
Workshop
Room: Mountain/Lake Rooms

Speaker 1 of 7
* Leslie J. Crofford, University of Kentucky, USA

Friday, March 14 | 8:00PM - 10:00PM
Workshop
Room: Mountain/Lake Rooms

Speaker 2 of 7
Christine D. Harman, Michigan State University, USA
Crystal Structure of Aracidonic Acid Bound to a Mutant of Prostaglandin Endoperoxide Synthase-1 That Forms 11-HPETE instead of PGG2

Friday, March 14 | 8:00PM - 10:00PM
Workshop
Room: Mountain/Lake Rooms

Speaker 3 of 7
Betty P. Stamatiou, Merck Frosst, Canada
5-Oxo-ETE is an Angiogenic Factor for Human Endothelial Cells

Friday, March 14 | 8:00PM - 10:00PM
Workshop
Room: Mountain/Lake Rooms

Speaker 4 of 7
Sung-Hoon Cho, Korea University, South Korea
IgE-Dependent Leukotriene Synthesis via Rac-PKC-Delta-Linked Cascade in RBL-2H3 Mast Cells

Friday, March 14 | 8:00PM - 10:00PM
Workshop
Room: Mountain/Lake Rooms

Speaker 5 of 7
Irving C. Allen, Virginia Tech, USA
The Thromboxane A2 Receptor Agonist U46619 Induces Airway Hyperresponsiveness by the Activation of Neural Pathways in Mice

Friday, March 14 | 8:00PM - 10:00PM
Workshop
Room: Mountain/Lake Rooms

Speaker 6 of 7
Santosh K. Ramamurthy, University of Illinois at Chicago, USA
Role of the TXA2 Receptor in Oligodendrocyte Differentiation

Friday, March 14 | 8:00PM - 10:00PM
Workshop
Room: Mountain/Lake Rooms

Speaker 7 of 7
Stacia Kargman, Merck Frosst Canada & Company, Canada
Rofecoxib Attenuates Tumors and Metastases and Increases Survival in a Mouse Model of Colorectal Cancer

Saturday, March 15 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Saturday, March 15 | 8:00AM - 11:15AM
Leukotriene Receptors
Room: Mountain/Lake Rooms

Speaker 1 of 6
* Takao Shimizu, University of Tokyo, Japan

Saturday, March 15 | 8:00AM - 11:15AM
Leukotriene Receptors
Room: Mountain/Lake Rooms

Speaker 2 of 6
Takashi Izumi, Gunma University School of Medicine, Japan
Molecular Cloning and Regulation of Two Leukotriene B4 Receptors

Saturday, March 15 | 8:00AM - 11:15AM
Leukotriene Receptors
Room: Mountain/Lake Rooms

Speaker 3 of 6
Jilly F. Evans, PharmAkea Therapeutics, USA
Cysteinyl Leukotriene Receptors

Saturday, March 15 | 8:00AM - 11:15AM
Leukotriene Receptors
Room: Mountain/Lake Rooms

Speaker 4 of 6
Joseph Parello, Centre National de la Recherche Scientifique, France
Structure-Based Analysis of GPCR Function: The Leukotriene Receptors Expressed in Escherichia coli

Saturday, March 15 | 8:00AM - 11:15AM
Leukotriene Receptors
Room: Mountain/Lake Rooms

Speaker 5 of 6
Colin D. Funk, Queen's University, Canada
Transgenic Cysteinyl Leukotriene Receptor Mice

Saturday, March 15 | 8:00AM - 11:15AM
Leukotriene Receptors
Room: Mountain/Lake Rooms

Speaker 6 of 6
Jana Stankova, Université de Sherbrooke, Canada
Modulation of Expression and Function of Leukotriene Receptors

Saturday, March 15 | 9:00AM - 12:00PM
Entertainment
Room: Mountain/Lake Rooms


Saturday, March 15 | 9:00AM - 12:00PM
Cash Bar
Room: Mountain/Lake Rooms


Saturday, March 15 | 9:20AM - 9:40AM
Coffee Break
Room: Pre-Function


Saturday, March 15 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Pre-Function


Saturday, March 15 | 5:00PM - 7:30PM
Eicosanoids and Disease
Room: Mountain/Lake Rooms

Speaker 1 of 5
* K. Frank Austen, Harvard Medical School, USA

Saturday, March 15 | 5:00PM - 7:30PM
Eicosanoids and Disease
Room: Mountain/Lake Rooms

Speaker 2 of 5
Sally Wenzel-Morganroth, University of Pittsburgh, USA
The Role of Lipoxygenase Products in Asthma

Saturday, March 15 | 5:00PM - 7:30PM
Eicosanoids and Disease
Room: Mountain/Lake Rooms

Speaker 3 of 5
Leslie J. Crofford, University of Kentucky, USA
Prostaglandins in Arthritis: Implications for Treatment

Saturday, March 15 | 5:00PM - 7:30PM
Eicosanoids and Disease
Room: Mountain/Lake Rooms

Speaker 4 of 5
Andreas J. R. Habenicht, Institute for Prophylaxis of Cardiovascular Diseases, Germany
The 5-Lipoxygenase (5-LO) Pathway Constitutes Inflammatory Circuits in Diseased Arteries during Human Atherogenesis

Saturday, March 15 | 5:00PM - 7:30PM
Eicosanoids and Disease
Room: Mountain/Lake Rooms

Speaker 5 of 5
Colin D. Funk, Queen's University, Canada

Saturday, March 15 | 7:00PM - 8:00PM
Social Hour
Room: Granhall


Saturday, March 15 | 8:00PM - 9:00PM
Dinner
Room: Mountain/Lake Rooms


Sunday, March 16 | 10:26AM - 10:26AM
Departure


*Session Chair.