Eicosanoid Lipid Mediators: From Molecular Discovery to Clinical Application

Organizer(s): Jilly F. Evans, Colin D. Funk and Takao Shimizu

Sponsored by Aventis Pharmaceuticals, Inc.

Summary of Meeting:

Recent advances in the cloning and molecular characterization of eicosanoid pathway enzymes and receptors have provided both new structural, functional and genetic information and novel therapeutic targets. Eicosanoid pathway inhibitors (notably COX-2 inhibitors) and antagonists (notably CysLT1 receptor antagonists) have already found important places in the therapies of arthritis, pain and asthma. Novel applications for eicosanoid pathway modulators include other inflammatory and allergic diseases and cancer. The goal of the Keystone meeting in 2003 will be to combine state-of-the-art basic biology, including biochemistry, pharmacology and structural and genetic biology, with application of this knowledge to human therapeutics. This meeting will encourage scientific networking amongst different academic disciplines and industrial speakers in an informal and friendly atmosphere conducive to sharing latest data and building further collaborations. The key organizer is a woman and there will be a strong representation of women and minority speakers and interactive talks, eicosanoid trivia quizzes, poster prizes and special social events to encourage maximum scientific and social interactions. Specific topics will include cyclooxygenase structure and function and clinical benefit of cyclooxygenase-2 inhibitors, prostaglandin receptor expression, function and disease targets, lipoxygenases and leukotriene receptor cell biology and genetics, and clinical applications of eicosanoid pathway modulators.

Discounted Abstract Deadline: November 11 2002

Discounted Registration Deadline: January 13 2003

We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1 R13 AI053151-01

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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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