Web Desc
Signaling via Cell-Cell Interactions
Organizer(s): Rudy L. Juliano and Keith W.T. Burridge
Date: March 18 - 23, 2003
Location: Keystone Resort, Keystone, CO, USA
Supported by Keystone Symposia
For important information on the coronavirus, please click here
Summary of Meeting:
Over the last decade it has become clear that many key signal transduction processes are strongly influenced by transmembrane cell adhesion molecules and by their associated cytoskeletal partners. In particular there has been a great deal of progress in understanding how integrin-mediated adhesion to the extracellular matrix leads to the organization of supramolecular complexes of structural and signaling proteins, and how these complexes then regulate the efficiency of signaling pathways. More recently, evidence is beginning to emerge that cell-cell adhesion molecules, including cadherins and immunoglobulin-superfamily proteins, also have strong impacts on signal transduction. Cell-cell adhesion molecule (CAM) mediated signaling seems to be particularly important in the context of the nervous system, and in the context of the organization of polarized epithelia. Thus this proposed Keystone Symposia intends to address several key aspects of the emerging research theme of CAMs and their role in signaling pathways affecting mitogenesis, cell survival, and cell differentiation.
Discounted Abstract Deadline: November 18 2002
Discounted Registration Deadline: January 21 2003
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1 R13 CA099389-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, March 18 | 3:00PM - 7:00PM
Registration
Room: Shavano Peak Foyer


Tuesday, March 18 | 6:15PM - 7:15PM
Welcome
Room: Shavano Peak Foyer


Tuesday, March 18 | 7:15PM - 7:30PM
Orientation
Room: Shavano Peak


Wednesday, March 19 | 8:30AM - 9:30AM
Breakfast
Room: Red Cloud


Wednesday, March 19 | 11:00AM - 1:00PM
Poster Setup
Room: Torreys Peak


Wednesday, March 19 | 1:00PM - 10:00PM
Poster Viewing
Room: Torreys Peak


Wednesday, March 19 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Shavano Peak Foyer


Wednesday, March 19 | 5:00PM - 6:45PM
Epithelial Cell Junctions, Rho GTPases and Signaling I
Room: Shavano Peak

Speaker 1 of 3
* Yoshimi Takai, Osaka University Graduate School of Medicine, Japan
Roles and Modes of Action of Nectin and Afadin in Formation of Intercellular Junctions

Wednesday, March 19 | 5:00PM - 6:45PM
Epithelial Cell Junctions, Rho GTPases and Signaling I
Room: Shavano Peak

Speaker 2 of 3
Vania M.M. Braga, Imperial College, Faculty of Medicine, UK
Rho Proteins and Cadherin Receptors

Wednesday, March 19 | 5:00PM - 6:45PM
Epithelial Cell Junctions, Rho GTPases and Signaling I
Room: Shavano Peak

Speaker 3 of 3
Celeste M. Nelson, Princeton University, USA
Short Talk: VE-Cadherin, Focal Adhesions and Mechanotransduction

Wednesday, March 19 | 6:45PM - 7:00PM
Integrins and Signal Transduction
Room: Shavano Peak

Speaker 1 of 1
Valerie G. Brunton, CR-UK Beatson Institute for Cancer Research, UK
Short Talk: Src Tyrosine Kinase-Dependent Adhesion Changes in A Model of Colon Cancer Metastasis

Wednesday, March 19 | 7:00PM - 8:00PM
Social Hour
Room: Torreys Peak


Wednesday, March 19 | 8:00PM - 10:00PM
Poster Session
Room: Torreys Peak


Thursday, March 20 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud


Thursday, March 20 | 8:00AM - 8:40AM
Epithelial Cell Junctions, Rho GTPases and Signaling II
Room: Shavano Peak

Speaker 1 of 2
Shoichiro Tsukita, Kyoto University, Japan
Cancelled Due to Weather

Thursday, March 20 | 8:00AM - 8:40AM
Epithelial Cell Junctions, Rho GTPases and Signaling II
Room: Shavano Peak

Speaker 2 of 2
* Keith W.T. Burridge, University of North Carolina at Chapel Hill, USA
Signaling from Cadherins to RhoA

Thursday, March 20 | 8:40AM - 9:20AM
CAMs and Nucleocytoplasmic Trafficking
Room: Shavano Peak

Speaker 1 of 1
Charles Streuli, University of Manchester, UK
Adhesion Signals for Differentiation and Survival in Mammary Epithelium

Thursday, March 20 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Thursday, March 20 | 9:40AM - 10:45AM
Epithelial Cell Junctions, Rho GTPases and Signaling II
Room: Shavano Peak

Speaker 1 of 3
Yasuyuki Fujita, Hokkaido University, Japan
Short Talk

Thursday, March 20 | 9:40AM - 10:45AM
Epithelial Cell Junctions, Rho GTPases and Signaling II
Room: Shavano Peak

Speaker 2 of 3
Alec E. Vaezi, Rockefeller University, USA
Short Talk: Actin Cable Dynamics and Rho/Rock Orchestrate a Polarized Cytoskeletal Architecture in Early Steps of Assembling a Stratified Epithelium

Thursday, March 20 | 9:40AM - 10:45AM
Epithelial Cell Junctions, Rho GTPases and Signaling II
Room: Shavano Peak

Speaker 3 of 3
Estelle Sontag, University of Texas Southwestern Medical Center, USA
Short Talk: PP2A Critically Regulates the Actin Cytoskeleton and Assembly of Epithelial Tight Junctions

Thursday, March 20 | 10:45AM - 11:00AM
Integrins and Signal Transduction
Room: Shavano Peak

Speaker 1 of 1
Kerstin Danker, Charite - Universitaetsmedizin Berlin, Germany
Short Talk: Alpha1Beta1 Integrin-Mediated Post-Ligand Events Require the Cytoplasmic Sequence of the Alpha1 Integrin Subunit

Thursday, March 20 | 11:00AM - 1:00PM
Poster Setup
Room: Torreys Peak


Thursday, March 20 | 1:00PM - 10:00PM
Poster Viewing
Room: Torreys Peak


Thursday, March 20 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Shavano Peak Foyer


Thursday, March 20 | 5:00PM - 5:45PM
Keynote Address
Room: Shavano Peak

Speaker 1 of 1
W. James Nelson, Stanford University, USA
How Simple Epithelial Cells Form Cell-Cell Adhesions

Thursday, March 20 | 5:45PM - 7:00PM
PAR Genes and Epithelial Polarity
Room: Shavano Peak

Speaker 1 of 2
Daniel St. St Johnston, University of Cambridge, UK
The Roles of Drosophila PAR-1, LKB1 and 14-3-3 in Anterior-Posterior Axis Formation and Epithelial Polarity

Thursday, March 20 | 5:45PM - 7:00PM
PAR Genes and Epithelial Polarity
Room: Shavano Peak

Speaker 2 of 2
* Dietmar Vestweber, Max Planck Institute for Molecular Biomedicine, Germany
Regulation of Endothelial Cell Contacts

Thursday, March 20 | 7:00PM - 8:00PM
Social Hour
Room: Torreys Peak


Thursday, March 20 | 8:00PM - 10:00PM
Poster Session
Room: Torreys Peak


Friday, March 21 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud


Friday, March 21 | 8:00AM - 8:40AM
Leukocyte Interactions
Room: Shavano Peak

Speaker 1 of 1
Elisabetta Dejana, Uppsala University, Sweden
Signaling through Endothelial Junctions

Friday, March 21 | 8:40AM - 9:20AM
Integrins and Signal Transduction
Room: Shavano Peak

Speaker 1 of 1
* Joan S. Brugge, Harvard Medical School, USA
VAV - A Critical Regulator of Rho GTPases

Friday, March 21 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Friday, March 21 | 9:40AM - 11:00AM
Epithelial Cell Junctions, Rho GTPases and Signaling
Room: Shavano Peak

Speaker 1 of 3
Andrea I. McClatchey, Massachusetts General Hospital, USA
Short Talk: NF2-Deficiency Promotes Tumorigenesis and Metastasis by Destabilizing Adherens Junctions

Friday, March 21 | 9:40AM - 11:00AM
Epithelial Cell Junctions, Rho GTPases and Signaling
Room: Shavano Peak

Speaker 2 of 3
Pierre D. McCrea, University of Texas MD Anderson Cancer Center, USA
Short Talk: Vertebrate Development Requires Interplay of p120- and ARVCF-Catenins with Rho-Family GTPases

Friday, March 21 | 9:40AM - 11:00AM
Epithelial Cell Junctions, Rho GTPases and Signaling
Room: Shavano Peak

Speaker 3 of 3
Cara J. Gottardi, Northwestern University, USA
Short Talk: Distinct Biochemical Pools of b-Catenin Exhibit Differential Binding to Cadherin and TCF: Implications for wnt Signaling and Adhesion

Friday, March 21 | 1:00PM - 10:00PM
Poster Viewing
Room: Torreys Peak


Friday, March 21 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Shavano Peak Foyer


Friday, March 21 | 5:00PM - 7:00PM
CAMs, Signaling and Neuronal Guidance
Room: Shavano Peak

Speaker 1 of 3
* Louis F. Reichardt, University of California, San Francisco, USA
Adhesive Signaling in Neural Development

Friday, March 21 | 5:00PM - 7:00PM
CAMs, Signaling and Neuronal Guidance
Room: Shavano Peak

Speaker 2 of 3
Morgan H. Sheng, Broad Institute, USA
The Dynamic Organization of Synaptic Junctions

Friday, March 21 | 5:00PM - 7:00PM
CAMs, Signaling and Neuronal Guidance
Room: Shavano Peak

Speaker 3 of 3
Spyros Artavanis-Tsakonas, Harvard Medical School and Biogen Idec, USA
Notch Signaling

Friday, March 21 | 7:00PM - 7:30PM
Scaffolds, the Cytoskeleton and Signaling
Room: Shavano Peak

Speaker 1 of 1
Mark L. Dell'Acqua, University of Colorado, USA
Short Talk: AKAP79 Binding to Cadherins: Polarized Targeting of a Kinase-Phosphatase Signaling Scaffold to Cell-Cell Contacts in Neurons and Epithelial Cells

Friday, March 21 | 7:30PM - 8:30PM
Social Hour
Room: Torreys Peak


Friday, March 21 | 8:00PM - 10:00PM
Poster Session
Room: Torreys Peak


Saturday, March 22 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud


Saturday, March 22 | 8:00AM - 9:20AM
Scaffolds, the Cytoskeleton and Signaling
Room: Shavano Peak

Speaker 1 of 2
* Rudy L. Juliano, University of North Carolina at Chapel Hill, USA
Regulation of Signal Transduction by Integrins and the Cytoskeleton

Saturday, March 22 | 8:00AM - 9:20AM
Scaffolds, the Cytoskeleton and Signaling
Room: Shavano Peak

Speaker 2 of 2
Filippo G. Giancotti, Memorial Sloan-Kettering Cancer Center, USA
Genetic Analysis of Integrin Alpha-6 Beta-4 Signaling


Saturday, March 22 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Saturday, March 22 | 9:20AM - 10:15AM
CAMs and Nucleocytoplasmic Trafficking
Room: Shavano Peak

Speaker 1 of 3
Ruggero Pardi, San Raffaele University School of Medicine, Italy
Cancelled Due to Weather

Saturday, March 22 | 9:20AM - 10:15AM
CAMs and Nucleocytoplasmic Trafficking
Room: Shavano Peak

Speaker 2 of 3
* Mary C. Beckerle, Huntsman Cancer Institute, USA
LIM Proteins that Modulate Integrin Function

Saturday, March 22 | 9:20AM - 10:15AM
CAMs and Nucleocytoplasmic Trafficking
Room: Shavano Peak

Speaker 3 of 3
Donald M. Black, Beatson Institute, UK
Short Talk: TES is a Focal Adhesion LIM Domain Protein that Interacts with ZYXIN, MENA and TALIN

Saturday, March 22 | 10:15AM - 11:30AM
Potential Therapeutic Targets Based on Cell Interactions
Room: Shavano Peak

Speaker 1 of 3
* David R. Phillips, Portola Pharmaceuticals Inc., USA
Therapeutic Regulation of alphaIIbbeta3: Surprising Effect on CD40L and
Inflammation


Saturday, March 22 | 10:15AM - 11:30AM
Potential Therapeutic Targets Based on Cell Interactions
Room: Shavano Peak

Speaker 2 of 3
Diane Baronas-Lowell, Florida Atlantic University, USA
Short Talk: Endothelial Cell Activation Induced by ECM 'Mini-Proteins'

Saturday, March 22 | 10:15AM - 11:30AM
Potential Therapeutic Targets Based on Cell Interactions
Room: Shavano Peak

Speaker 3 of 3
Mario M. Müller, Institute of Molecular Biology and Biochemistry, Germany
Short Talk: CEACAM1 (CD66a) A Potent Regulator of Endothelial Differentiation

Saturday, March 22 | 11:00AM - 10:00PM
Poster Viewing
Room: Torreys Peak


Saturday, March 22 | 4:00PM - 4:30PM
Coffee & Snacks Available
Room: Shavano Peak Foyer


Saturday, March 22 | 4:45PM - 5:30PM
Leukocyte Interactions
Room: Shavano Peak

Speaker 1 of 3
John D. Scott, University of Washington, USA
Cancelled Due to Weather

Saturday, March 22 | 4:45PM - 5:30PM
Leukocyte Interactions
Room: Shavano Peak

Speaker 2 of 3
* Peter J. Newman, Blood Center of Wisconsin, USA
Novel Roles for PECAM-1 in the Biology of Blood and Vascular Cells

Saturday, March 22 | 4:45PM - 5:30PM
Leukocyte Interactions
Room: Shavano Peak

Speaker 3 of 3
Michael L. Dustin, University of Oxford, UK
The Immunological Synapse: A Signaling Paradox Resolved

Saturday, March 22 | 5:30PM - 6:30PM
PAR Genes and Epithelial Polarity
Room: Shavano Peak

Speaker 1 of 2
Shigeo Ohno, Yokohama City University School of Medicine, Japan
Cancelled Due to Weather

Saturday, March 22 | 5:30PM - 6:30PM
PAR Genes and Epithelial Polarity
Room: Shavano Peak

Speaker 2 of 2
Christopher E. Rudd, University of Montreal, Canada
Short Talk: Adaptors ADAP and SKAP-55 Regulate Integrin Adhesion and T Cell/APC Conjugate Formation

Saturday, March 22 | 6:30PM - 7:30PM
Potential Therapeutic Targets Based on Cell Interactions
Room: Shavano Peak

Speaker 1 of 3
Frank Struyf, Northwestern University, USA
Short Talk: Constitutive Upregulation of an Interferon Response Pathway in Fibroblasts Lacking Full-Length Nectin-1

Saturday, March 22 | 6:30PM - 7:30PM
Potential Therapeutic Targets Based on Cell Interactions
Room: Shavano Peak

Speaker 2 of 3
Carlos Rosales, Instituto de Investigaciones Biomedicas - UNAM, Mexico
Short Talk: Beta1 and Beta2 Integrins Activate Different Signaling Pathways in Monocytes

Saturday, March 22 | 6:30PM - 7:30PM
Potential Therapeutic Targets Based on Cell Interactions
Room: Shavano Peak

Speaker 3 of 3
John P. O'Bryan, Medical University of South Carolina, USA
Short Talk: Intersectin Activates Ras and c-Jun N-Terminal Kinase and is Negatively Regulated by Src and p38 MAPK

Saturday, March 22 | 7:30PM - 8:30PM
Social Hour
Room: Torreys Peak


Saturday, March 22 | 8:30PM - 11:30PM
Cash Bar
Room: Torreys Peak


Saturday, March 22 | 8:30PM - 11:30PM
Entertainment
Room: Torreys Peak


Sunday, March 23 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.