Proteomics: Technologies and Applications

Organizer(s): Ruedi Aebersold and Stanley Fields

Supported by Keystone Symposia

Summary of Meeting:

The completion of the genomic sequences of a number of prokaryotic and eukaryotic species has catalyzed new research approaches to study the structure, function, and control of biological processes. They are characterized by the systematic and, in many cases, quantitative analysis of all the molecules of a particular type expressed by a cell or tissue. The systematic analysis of proteins has been termed 'proteomics.' In an initial phase, most of the proteomics efforts were focused on large-scale protein identification. More recently, the objectives and technologies of proteomics have diversified and expanded. Current proteomics research attempts to systematically and, where applicable, quantitatively determine the many properties of proteins that determine their biological function. These include protein abundance, state of modification, specific activity, interaction with other biomolecules, half-life, subcellular location, structure, and more. Significant current challenges include the development of suitable technologies to determine these properties on a proteome-wide scale, the interpretation of the large amounts of data obtained, the development of computational approaches to infer biological function, and the integration of different types of data into a coherent model describing a biological process. The goal of the meeting is to bring together leading experts from the different areas of proteomics research to discuss emerging technologies and their applications to biological and clinical research.

Discounted Abstract Deadline: November 25 2002

Discounted Registration Deadline: January 27 2003

We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Environmental Health Sciences (NIEHS)
Grant No. 1 R13 ES012094-01

National Nuclear Security Administration (DOE/NNSA)
Grant No. DE-FO03-03ER63517

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