Web Desc
Molecular Aspects of Transmissible Spongiform Encephalopathies (Prion Diseases)
Organizer(s): Byron Caughey, Charles Weissmann, Suzette Priola and Bruce Chesebro
Date: April 02 - 06, 2003
Location: Beaver Run Resort, Breckenridge, CO, USA
Sponsored by Roche Diagnostics
Summary of Meeting:
The epidemic of bovine spongiform encephalopathy and its spread into humans has led to a marked expansion of research on the molecular bases of transmissible spongiform encephalopathies (TSE) or prion diseases. Studies with transgenic and prion protein (PrP)-knockout mice have established that PrP is critical in TSE transmission and pathogenesis. Much has been learned about the normal structure and folding options of recombinant PrP molecules and the interactions and interconversions between normal and TSE-associated PrP isoforms. Functional studies have suggested possible normal and disease associated roles for PrP. However, the essential nature of the infectious agent, the structure of TSE-associated PrP isoforms, and the mechanism(s) by which they cause disease are not yet clear. Furthermore, practical therapies and ante-mortem diagnostic tests are sorely lacking. This symposium will attempt to summarize the state of the field and to consider solutions to the problems posed by these enigmatic diseases.
Discounted Abstract Deadline: December 3 2002
Discounted Registration Deadline: February 3 2003
We gratefully acknowledge additional support for this conference from:
Roche Diagnostics GmbH
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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Program

Wednesday, April 02 | 3:00PM - 7:00PM
Registration
Room: Third Floor Foyer


Wednesday, April 02 | 6:15PM - 7:15PM
Welcome
Room: Third Floor Foyer


Wednesday, April 02 | 7:15PM - 7:30PM
Orientation
Room: Peaks 4-5


Wednesday, April 02 | 7:30PM - 8:30PM
Keynote Address
Room: Peaks 4-5

Speaker 1 of 1
Stanley B. Prusiner, University of California, San Francisco, USA
Prion Diagnostics and Therapeutics

Thursday, April 03 | 7:00AM - 8:00AM
Breakfast
Room: Peaks 6-12


Thursday, April 03 | 8:00AM - 11:00AM
TSE Agents and Pathogenesis
Room: Peaks 4-5

Speaker 1 of 7
* Byron Caughey, Rocky Mountain Laboratories, NIAID, National Institutes of Health, USA

Thursday, April 03 | 8:00AM - 11:00AM
TSE Agents and Pathogenesis
Room: Peaks 4-5

Speaker 2 of 7
Adriano M. Aguzzi, University Hospital of Zürich, Switzerland
Immunobiology of Prion Diseases

Thursday, April 03 | 8:00AM - 11:00AM
TSE Agents and Pathogenesis
Room: Peaks 4-5

Speaker 3 of 7
Bruce W. Chesebro, Rocky Mountain Laboratories, NIAID, National Institutes of Health, USA
Changes in PrP-res Conformation Associated with Scrapie Strains and Cross-Species Scrapie Infection

Thursday, April 03 | 8:00AM - 11:00AM
TSE Agents and Pathogenesis
Room: Peaks 4-5

Speaker 4 of 7
John Collinge, University College London, UK
Prion Strains and Interspecies Transmission

Thursday, April 03 | 8:00AM - 11:00AM
TSE Agents and Pathogenesis
Room: Peaks 4-5

Speaker 5 of 7
Pierluigi Gambetti, Case Western Reserve University, USA
PrPsc Species in Human Prion Diseases

Thursday, April 03 | 8:00AM - 11:00AM
TSE Agents and Pathogenesis
Room: Peaks 4-5

Speaker 6 of 7
Richard A. Bessen, Montana State University, USA
Short Talk: Rapid Prion Neuroinvasion Following Extraneural Inoculation of the Tongue is Independent of Agent Replication in the Lymphoreticular System

Thursday, April 03 | 8:00AM - 11:00AM
TSE Agents and Pathogenesis
Room: Peaks 4-5

Speaker 7 of 7
Glenn L. Millhauser, University of California, Santa Cruz, USA
Short Talk: The “Holo” Story of the Prion Protein – A First Look at PrP With All of its Copper Sites

Thursday, April 03 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Thursday, April 03 | 11:00AM - 1:00PM
Poster Setup
Room: Peaks 1-3


Thursday, April 03 | 1:00PM - 10:00PM
Poster Viewing
Room: Peaks 1-3


Thursday, April 03 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Foyer


Thursday, April 03 | 5:00PM - 7:00PM
Structures and Propagation of Prion Proteins
Room: Peaks 4-5

Speaker 1 of 5
* Witold K. Surewicz, Case Western Reserve University, USA

Thursday, April 03 | 5:00PM - 7:00PM
Structures and Propagation of Prion Proteins
Room: Peaks 4-5

Speaker 2 of 5
Kurt Wüthrich, ETH Zürich, Switzerland
Species Variation of the 3D Structure of the Cellular Prion Protein

Thursday, April 03 | 5:00PM - 7:00PM
Structures and Propagation of Prion Proteins
Room: Peaks 4-5

Speaker 3 of 5
Reed B. Wickner, National Institutes of Health, USA
[URE3] Prion is a Self-Propagating Amyloid of Ure2p: Mechanisms

Thursday, April 03 | 5:00PM - 7:00PM
Structures and Propagation of Prion Proteins
Room: Peaks 4-5

Speaker 4 of 5
Susan Lindquist, HHMI/Whitehead Institute for Biomedical Research, USA
Yeast to Mice: Model Systems in Neurodegenerative Disease

Thursday, April 03 | 5:00PM - 7:00PM
Structures and Propagation of Prion Proteins
Room: Peaks 4-5

Speaker 5 of 5
Susan W. Liebman, University of Illinois, USA
Short Talk: Prions Destabilize Other Prions: Unstable [PSI+] Variants

Thursday, April 03 | 7:00PM - 8:00PM
Social Hour
Room: Peaks 1-3


Thursday, April 03 | 8:00PM - 10:00PM
Poster Session 1
Room: Peaks 1-3


Friday, April 04 | 7:00AM - 8:00AM
Breakfast
Room: Peaks 6-12


Friday, April 04 | 8:00AM - 11:00AM
Prion Protein and Pathogenesis
Room: Peaks 4-5

Speaker 1 of 7
* Pierluigi Gambetti, Case Western Reserve University, USA

Friday, April 04 | 8:00AM - 11:00AM
Prion Protein and Pathogenesis
Room: Peaks 4-5

Speaker 2 of 7
Charles Weissmann, Scripps Institute, USA
Propagation of Prions


Friday, April 04 | 8:00AM - 11:00AM
Prion Protein and Pathogenesis
Room: Peaks 4-5

Speaker 3 of 7
Jean C. Manson, Institute for Animal Health, Edinburgh, UK
Targeting the Murine Prnp Gene

Friday, April 04 | 8:00AM - 11:00AM
Prion Protein and Pathogenesis
Room: Peaks 4-5

Speaker 4 of 7
Suehiro Sakaguchi, Nagasaki University Graduate School of Medicine, Japan
Roles of PrP and PrP-Like Protein (Doppel) in Neurodegeneration

Friday, April 04 | 8:00AM - 11:00AM
Prion Protein and Pathogenesis
Room: Peaks 4-5

Speaker 5 of 7
Martin Jeffrey, Lasswade Veterinary Laboratory, UK
Pathogenetic Significance of Disease-Specific PrP Accumulation Phenotypes

Friday, April 04 | 8:00AM - 11:00AM
Prion Protein and Pathogenesis
Room: Peaks 4-5

Speaker 6 of 7
Gerald S. Baron, Rocky Mountain Laboratories, NIAID, National Institutes of Health, USA
Short Talk: Effect of GPI-Anchor-Dependent and –Independent Prion Protein Association with Raft Membranes on Conversion to the Protease-Resistant Isoform

Friday, April 04 | 8:00AM - 11:00AM
Prion Protein and Pathogenesis
Room: Peaks 4-5

Speaker 7 of 7
Vilma R. Martins, Ludwig Institute for Cancer Research, Brazil
Short Talk: Is PrPc Loss-of-Function Associated to Human Epilepsies?

Friday, April 04 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Friday, April 04 | 11:00AM - 1:00PM
Poster Setup
Room: Peaks 1-3


Friday, April 04 | 1:00PM - 10:00PM
Poster Viewing
Room: Peaks 1-3


Friday, April 04 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Foyer


Friday, April 04 | 5:00PM - 7:00PM
Formation and Misfolding of PrP
Room: Peaks 4-5

Speaker 1 of 5
* Jean C. Manson, Institute for Animal Health, Edinburgh, UK

Friday, April 04 | 5:00PM - 7:00PM
Formation and Misfolding of PrP
Room: Peaks 4-5

Speaker 2 of 5
Suzette A. Priola, Rocky Mountain Laboratories, NIAID, National Institutes of Health, USA
PrP-res and Strain Glycoform Variation

Friday, April 04 | 5:00PM - 7:00PM
Formation and Misfolding of PrP
Room: Peaks 4-5

Speaker 3 of 5
David A. Harris, Washington University School of Medicine, USA
Biosynthesis and Metabolism of Wild-Type, Mutant, and Transmembrane PrP

Friday, April 04 | 5:00PM - 7:00PM
Formation and Misfolding of PrP
Room: Peaks 4-5

Speaker 4 of 5
Witold K. Surewicz, Case Western Reserve University, USA
Folding, Misfolding and Fibrillization of the Recombinant Prion Protein

Friday, April 04 | 5:00PM - 7:00PM
Formation and Misfolding of PrP
Room: Peaks 4-5

Speaker 5 of 5
Jerson Lima da Silva, Federal University of Rio de Janeiro, Brazil
Short Talk: Catalytic Action of Nucleic Acids on the Conversion of Prion Protein into the Beta-Sheet Conformation

Friday, April 04 | 7:00PM - 8:00PM
Social Hour
Room: Peaks 1-3


Friday, April 04 | 8:00PM - 10:00PM
Poster Session 2
Room: Peaks 1-3


Saturday, April 05 | 7:00AM - 8:00AM
Breakfast
Room: Peaks 6-12


Saturday, April 05 | 8:00AM - 11:00AM
Biochemical Aspects of Neuropathogenesis
Room: Peaks 4-5

Speaker 1 of 7
* David A. Harris, Washington University School of Medicine, USA

Saturday, April 05 | 8:00AM - 11:00AM
Biochemical Aspects of Neuropathogenesis
Room: Peaks 4-5

Speaker 2 of 7
Fabrizio Tagliavini, Carlo Besta National Neurological Institute, Italy
Neurotoxicity of Abnormal Forms and Fragments of PrP

Saturday, April 05 | 8:00AM - 11:00AM
Biochemical Aspects of Neuropathogenesis
Room: Peaks 4-5

Speaker 3 of 7
Sylvain Lehmann, Centre National de la Recherche Scientifique, France
Cellular Responses to Prion Infection

Saturday, April 05 | 8:00AM - 11:00AM
Biochemical Aspects of Neuropathogenesis
Room: Peaks 4-5

Speaker 4 of 7
David R. Brown, University of Bath, UK
Copper Binding and Antioxidant Activity of PrP

Saturday, April 05 | 8:00AM - 11:00AM
Biochemical Aspects of Neuropathogenesis
Room: Peaks 4-5

Speaker 5 of 7
James Hope, UK
Detection of Proteinase-K Resistant PrP in Sheep Blood by Immuno-Capillary Electrophoresis (ICE) and its Association with Scrapie : An Interim Report

Saturday, April 05 | 8:00AM - 11:00AM
Biochemical Aspects of Neuropathogenesis
Room: Peaks 4-5

Speaker 6 of 7
Rafael Linden, Instituto de Biofísica, Universidade Federal do Rio de Janeiro, Brazil
Short Talk: The Cellular Prion Protein Modulates Phagocytosis and Inflammatory Response

Saturday, April 05 | 8:00AM - 11:00AM
Biochemical Aspects of Neuropathogenesis
Room: Peaks 4-5

Speaker 7 of 7
Teresa J.T. Pinheiro, University of Warwick, UK
Short Talk: Aggregation and Fibrillization of Prion Proteins in Lipid Membranes

Saturday, April 05 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Saturday, April 05 | 2:30PM - 4:50PM
Workshop: Short Talks on Hot Topics

Speaker 1 of 8
* Suzette A. Priola, Rocky Mountain Laboratories, NIAID, National Institutes of Health, USA

Saturday, April 05 | 2:30PM - 4:50PM
Workshop: Short Talks on Hot Topics

Speaker 2 of 8
E. Fiona Houston, Institute for Animal Health, UK
Transmission of BSE to Sheep Thought to be Genetically Resistant to Infection

Saturday, April 05 | 2:30PM - 4:50PM
Workshop: Short Talks on Hot Topics

Speaker 3 of 8
Anna A. Bencsik, AFSSA, Agence Française de Sécurité Sanitaire des Aliments, France
A Neural Graft Approach in the Understanding of Florid Plaques Occurrence in Ovine BSE Infected Tg(OvPrP4) Mice

Saturday, April 05 | 2:30PM - 4:50PM
Workshop: Short Talks on Hot Topics

Speaker 4 of 8
Joëlle Chabry, Institut de Pharmacologie Moléculaire et Cellulaire, France
in vivo and in vitro Neurotoxicity of the Human Prion Protein
Fragment P118-135 Independently to PrP Expression


Saturday, April 05 | 2:30PM - 4:50PM
Workshop: Short Talks on Hot Topics

Speaker 5 of 8
Angela Y. Jen, King's College London, UK
PrPc Moves Out of Lipid Rafts to be Internalised

Saturday, April 05 | 2:30PM - 4:50PM
Workshop: Short Talks on Hot Topics

Speaker 6 of 8
Heike Eberl, Institut for Molecular Biology and Biophysics, Switzerland
Structure and Stability of Membrane-Attached, Recombinant Prion Protein

Saturday, April 05 | 2:30PM - 4:50PM
Workshop: Short Talks on Hot Topics

Speaker 7 of 8
Kerstin Elfrink, Heinrich-Heine-Universität, Germany
Conformational Transition of PrPC in vitro

Saturday, April 05 | 2:30PM - 4:50PM
Workshop: Short Talks on Hot Topics

Speaker 8 of 8
Ilia V. Baskakov, University of Maryland School of Medicine, USA
Pathway Complexity of the Prion Protein Assembly

Saturday, April 05 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Foyer


Saturday, April 05 | 5:00PM - 7:00PM
Diagnostics and Therapeutics
Room: Peaks 4-5

Speaker 1 of 5
* James Hope, UK

Saturday, April 05 | 5:00PM - 7:00PM
Diagnostics and Therapeutics
Room: Peaks 4-5

Speaker 2 of 5
Dominique Dormont, Commissariat a l'Energie Atomique, France
Therapeutic Strategies for Transmissible Spongiform Encephalopathies

Saturday, April 05 | 5:00PM - 7:00PM
Diagnostics and Therapeutics
Room: Peaks 4-5

Speaker 3 of 5
Hans Kretzschmar, Ludwig Maximilians University, Germany
Post-Exposure Prophylaxis against Prion Disease using a Stimulator of Innate Immunity

Saturday, April 05 | 5:00PM - 7:00PM
Diagnostics and Therapeutics
Room: Peaks 4-5

Speaker 4 of 5
Jiri G. Safar, University of California, San Francisco, USA
Detection and Strain-Dependent Differences in the Disease-Causing Prion Protein (PrPSc)

Saturday, April 05 | 5:00PM - 7:00PM
Diagnostics and Therapeutics
Room: Peaks 4-5

Speaker 5 of 5
Robert B. Peterson, Case Western Reserve University, USA
Short Talk: Diagnostics and TSEs: A Case for Simplicity

Saturday, April 05 | 7:00PM - 8:00PM
Social Hour
Room: Peaks 1-3


Saturday, April 05 | 8:00PM - 11:00PM
Entertainment
Room: Peaks 1-3


Saturday, April 05 | 8:00PM - 11:00PM
Cash Bar
Room: Peaks 1-3


Sunday, April 06 | 10:26AM - 10:26AM
Departure


*Session Chair.