Web Desc
Regulatory and Effector Functions of Macrophages
joint with Linking Innate with Adaptive Immune Responses
Organizer(s): David M. Mosser, Christopher L. Karp and Siamon Gordon
Date: January 30 - February 04, 2003
Location: Taos Convention Center (meeting only), Taos, New Mexico, USA
Supported by Keystone Symposia
For important information on the coronavirus, please click here
Summary of Meeting:
Macrophages occupy a unique niche in the immune system, in that they not only can initiate immune responses but they can also be effector cells which contribute to the resolution of these responses. The immunologic activation of macrophages can cause dramatic differences in their physiology. It is now well-appreciated that there is no single activation phenotype, and that macrophages can be induced to differentiate into cells that either exacerbate or inhibit inflammation. Similarly, these cells can promote, deviate, or suppress adaptive immune responses. The various states of macrophage activation and the mechanism of their induction will be examined. These discussions should lead to a better understanding of how specific alterations in macrophage physiology can contribute to or ameliorate inflammation, immune deviation, and the elimination of microbial pathogens.
Discounted Abstract Deadline: September 30 2002
Discounted Registration Deadline: December 2 2002
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1 R13 AI053716-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Thursday, January 30 | 3:00PM - 7:00PM
Registration
Room: Rio Grande Hall D


Thursday, January 30 | 6:15PM - 7:15PM
Welcome
Room: Rio Grande Hall A-C


Thursday, January 30 | 7:15PM - 7:30PM
Orientation
Room: Bataan


Thursday, January 30 | 7:30PM - 8:30PM
Keynote Address (Joint)
Room: Bataan

Speaker 1 of 1
Jules A. Hoffmann, Institute of Cellular and Molecular Biology, France
Drosophila Host Defense: Innate Immunity in Drosophila

Friday, January 31 | 7:00AM - 8:00AM
Breakfast
Room: Rio Grande Hall B-D


Friday, January 31 | 8:00AM - 11:00AM
Receptors of Innate Immunity: Toll-Like Receptors (Joint)
Room: Bataan

Speaker 1 of 4
Ruslan Medzhitov, HHMI/Yale University School of Medicine, USA
Pattern Recognition Receptors of Innate Immunity

Friday, January 31 | 8:00AM - 11:00AM
Receptors of Innate Immunity: Toll-Like Receptors (Joint)
Room: Bataan

Speaker 2 of 4
Alan Aderem, Center for Infectious Disease Research, USA
The Role of Toll-Like Receptors in Orchestrating the Innate Immune Response

Friday, January 31 | 8:00AM - 11:00AM
Receptors of Innate Immunity: Toll-Like Receptors (Joint)
Room: Bataan

Speaker 3 of 4
* Alan Ezekowitz, Abide Therapeutics, USA
Pattern Recognition Receptors in Flies and Man

Friday, January 31 | 8:00AM - 11:00AM
Receptors of Innate Immunity: Toll-Like Receptors (Joint)
Room: Bataan

Speaker 4 of 4
Ann Marshak-Rothstein, University of Massachusetts Medical School, USA
Chromatin, Toll-Like Receptor 9, and Systemic Autoimmune Disease

Friday, January 31 | 9:20AM - 9:40AM
Coffee Break
Room: Rio Grande Hall B-D


Friday, January 31 | 2:00PM - 3:00PM
Poster Setup
Room: Bataan


Friday, January 31 | 2:30PM - 4:30PM
Workshop 1: Signaling in Macrophages and Dendritic Cells
Room: Rio Grande Hall C-D

Speaker 1 of 5
* Pamela A. Hankey, Pennsylvania State University, USA
The STK Receptor Tyrosine Kinase Regulates the Response of Macrophages to Cytokine/LPS Stimulation and the Balance between Classical vs. Alternative Activation

Friday, January 31 | 2:30PM - 4:30PM
Workshop 1: Signaling in Macrophages and Dendritic Cells
Room: Rio Grande Hall C-D

Speaker 2 of 5
Katherine C. Brittingham, US Army Medical Research Institute of Infectious Diseases, USA
Regulation of Macrophage Function by the Adipocyte Fatty Acid Binding Protein, aP2

Friday, January 31 | 2:30PM - 4:30PM
Workshop 1: Signaling in Macrophages and Dendritic Cells
Room: Rio Grande Hall C-D

Speaker 3 of 5
Satoshi Uematsu, Research Institute for Microbial Diseases, Japan
Gene Regulation and in vivo Role of Membrane Bound PGE2 Synthase

Friday, January 31 | 2:30PM - 4:30PM
Workshop 1: Signaling in Macrophages and Dendritic Cells
Room: Rio Grande Hall C-D

Speaker 4 of 5
Jeffrey L. Curtis, University of Michigan, USA
Phospholipase C gamma2 (PLC gamma2) Occupies a Central Signaling Role during Phagocytosis of Apoptotic Cells by Mouse Macrophages

Friday, January 31 | 2:30PM - 4:30PM
Workshop 1: Signaling in Macrophages and Dendritic Cells
Room: Rio Grande Hall C-D

Speaker 5 of 5
Michael J. Rauh, BC Cancer Research Centre, Canada
SHIP-Deficiency Leads to Anti-Inflammatory Macrophage Programming

Friday, January 31 | 2:30PM - 4:30PM
Workshop 1: Innate Receptors, Signaling and Cell Death
This session is from Adaptive Immune Responses
Room: Rio Grande Hall A-B

Speaker 1 of 10
* Glenn K. Matsushima, University of North Carolina at Chapel Hill, USA
Novel Receptors in the Clearance of Apoptotic Cells


Friday, January 31 | 2:30PM - 4:30PM
Workshop 1: Innate Receptors, Signaling and Cell Death
This session is from Adaptive Immune Responses
Room: Rio Grande Hall A-B

Speaker 2 of 10
* Julie Djeu, Moffitt Cancer Center, USA


Friday, January 31 | 2:30PM - 4:30PM
Workshop 1: Innate Receptors, Signaling and Cell Death
This session is from Adaptive Immune Responses
Room: Rio Grande Hall A-B

Speaker 3 of 10
Michael R. Daws, University of California, San Francisco, USA
Pattern Recognition by TREM-2: Binding of Anionic Ligands


Friday, January 31 | 2:30PM - 4:30PM
Workshop 1: Innate Receptors, Signaling and Cell Death
This session is from Adaptive Immune Responses
Room: Rio Grande Hall A-B

Speaker 4 of 10
Hong Zhang, University of California, San Francisco, USA
Regulation of Leukocyte Chemokine Signaling by Src-Family Kinase and the Inhibitory Receptor PIR-B


Friday, January 31 | 2:30PM - 4:30PM
Workshop 1: Innate Receptors, Signaling and Cell Death
This session is from Adaptive Immune Responses
Room: Rio Grande Hall A-B

Speaker 5 of 10
Ross M. Kedl, University of Colorado Denver, USA
A TLR7 Agonist Selectively Induces IL-12 and TNFalpha Production in CD8-CD11b+CD11c+ Dendritic Cells


Friday, January 31 | 2:30PM - 4:30PM
Workshop 1: Innate Receptors, Signaling and Cell Death
This session is from Adaptive Immune Responses
Room: Rio Grande Hall A-B

Speaker 6 of 10
Arya Biragyn, NIA, National Institutes of Health, USA
Many Faces of Beta-Defensin: Activation of DC Maturation via TLR-4


Friday, January 31 | 2:30PM - 4:30PM
Workshop 1: Innate Receptors, Signaling and Cell Death
This session is from Adaptive Immune Responses
Room: Rio Grande Hall A-B

Speaker 7 of 10
Koichi Kobayashi, Yale University School of Medicine, USA
Negative Regulation of the Toll-Like Receptor System


Friday, January 31 | 2:30PM - 4:30PM
Workshop 1: Innate Receptors, Signaling and Cell Death
This session is from Adaptive Immune Responses
Room: Rio Grande Hall A-B

Speaker 8 of 10
Hidenori Ichijo, University of Tokyo, Japan
Roles of ASK1-p38 MAPK Cascade in Mammalian Innate Immunity


Friday, January 31 | 2:30PM - 4:30PM
Workshop 1: Innate Receptors, Signaling and Cell Death
This session is from Adaptive Immune Responses
Room: Rio Grande Hall A-B

Speaker 9 of 10
Heather M. Seitz, Pfizer Inc., USA
Relationship of Novel Receptor Tyrosine Kinases in Phagocytosis of Apoptotic Cells


Friday, January 31 | 2:30PM - 4:30PM
Workshop 1: Innate Receptors, Signaling and Cell Death
This session is from Adaptive Immune Responses
Room: Rio Grande Hall A-B

Speaker 10 of 10
Fabio Martinon, Harvard School of Public Health, USA
The Inflammasome: A Molecular Platform Triggering Activation of the Inflammatory Caspases and Processing of proIL-1beta


Friday, January 31 | 3:00PM - 10:00PM
Poster Viewing
Room: Bataan


Friday, January 31 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Bataan


Friday, January 31 | 5:00PM - 7:00PM
The Regulation of Cytokine Production in Leukocytes
Room: Rio Grande Hall C-D

Speaker 1 of 3
* Stephen T. Smale, University of California, Los Angeles, USA
Selective Activation of Cytokine Genes in Macrophages: Roles of Rel Proteins and Nucleosome Remodeling Complexes

Friday, January 31 | 5:00PM - 7:00PM
The Regulation of Cytokine Production in Leukocytes
Room: Rio Grande Hall C-D

Speaker 2 of 3
Giorgio Trinchieri, NCI, National Institutes of Health, USA
The Regulation of IL-12 Production

Friday, January 31 | 5:00PM - 7:00PM
The Regulation of Cytokine Production in Leukocytes
Room: Rio Grande Hall C-D

Speaker 3 of 3
Alberto Mantovani, Humanitas University, Italy
The Long Pentraxin PTX3: Non-Redundant Role in Innate Immunity and More

Friday, January 31 | 5:00PM - 7:00PM
Apoptosis and Innate Immunity
This session is from Adaptive Immune Responses
Room: Rio Grande Hall A-B

Speaker 1 of 3
Glenn K. Matsushima, University of North Carolina at Chapel Hill, USA
Novel Receptors in the Clearance of Apoptotic Cells


Friday, January 31 | 5:00PM - 7:00PM
Apoptosis and Innate Immunity
This session is from Adaptive Immune Responses
Room: Rio Grande Hall A-B

Speaker 2 of 3
* Averil I. Ma, University of California, San Francisco, USA
A20 and Innate Immune Responses


Friday, January 31 | 5:00PM - 7:00PM
Apoptosis and Innate Immunity
This session is from Adaptive Immune Responses
Room: Rio Grande Hall A-B

Speaker 3 of 3
Jeffrey C. Rathmell, Vanderbilt University, USA
Glucose Metabolism and Apoptosis


Friday, January 31 | 7:00PM - 8:00PM
Social Hour
Room: Bataan


Friday, January 31 | 8:00PM - 10:00PM
Poster Session 1: Macrophage Effector Mechanisms
Room: Bataan


Saturday, February 01 | 7:00AM - 8:00AM
Breakfast
Room: Bataan


Saturday, February 01 | 8:00AM - 11:00AM
Modulation of Immune Responses by Antigen Presenting Cells
Room: Rio Grande Hall C-D

Speaker 1 of 4
Anne O'Garra, Francis Crick Institute, UK
Flexibility of Mouse Classical and Plasmacytoid-Derived Dendritic Cells in Directing Th1 and Th2 Cell Development: Dependency on Antigen Dose and Differential Toll-Like Receptor Ligation

Saturday, February 01 | 8:00AM - 11:00AM
Modulation of Immune Responses by Antigen Presenting Cells
Room: Rio Grande Hall C-D

Speaker 2 of 4
* David M. Mosser, University of Maryland, USA
Biasing T Cell Responses by Modulating APC Cytokines

Saturday, February 01 | 8:00AM - 11:00AM
Modulation of Immune Responses by Antigen Presenting Cells
Room: Rio Grande Hall C-D

Speaker 3 of 4
Judith E. Allen, University of Manchester, UK
Th2 Cytokines and Macrophage Function in vivo

Saturday, February 01 | 8:00AM - 11:00AM
Modulation of Immune Responses by Antigen Presenting Cells
Room: Rio Grande Hall C-D

Speaker 4 of 4
Peter M. Henson, National Jewish Health Center and University of Colorado Denver, USA
Why Eating Dying Cells Does a Body Good: Anti-Inflammatory Responses to Apoptotic Cells

Saturday, February 01 | 8:00AM - 11:00AM
Model Systems of Innate Immunity
This session is from Adaptive Immune Responses
Room: Rio Grande Hall A-B

Speaker 1 of 4
Jeffery L. Dangl, University of North Carolina at Chapel Hill, USA
The Plant Immune System—Ancient Immunity While Standing Still


Saturday, February 01 | 8:00AM - 11:00AM
Model Systems of Innate Immunity
This session is from Adaptive Immune Responses
Room: Rio Grande Hall A-B

Speaker 2 of 4
Elena A. Levashina, Max Planck Institute for Infection Biology, Germany
Thioester-Containing Proteins in Immune Defense of Mosquitoes


Saturday, February 01 | 8:00AM - 11:00AM
Model Systems of Innate Immunity
This session is from Adaptive Immune Responses
Room: Rio Grande Hall A-B

Speaker 3 of 4
Frederick M. Ausubel, Massachusetts General Hospital, USA
The C. elegans Immune Defense Response


Saturday, February 01 | 8:00AM - 11:00AM
Model Systems of Innate Immunity
This session is from Adaptive Immune Responses
Room: Rio Grande Hall A-B

Speaker 4 of 4
* Alan Sher, NIAID, National Institutes of Health, USA
Innate Recognition of Toxoplasma gondii by Dendritic Cells


Saturday, February 01 | 9:20AM - 9:40AM
Coffee Break
Room: Bataan


Saturday, February 01 | 11:00AM - 1:00PM
Poster Setup
Room: Bataan


Saturday, February 01 | 1:00PM - 10:00PM
Poster Viewing
Room: Bataan


Saturday, February 01 | 2:30PM - 4:30PM
Workshop 2: Host Defense to Microbial Pathogens
Room: Rio Grande Hall C-D

Speaker 1 of 5
* Christian M. Bogdan, FAU Erlangen-Nürnberg, University Hospital Erlangen, Germany
The Role of NOS, NADPH oxidase and Type I Interferons in the Defense against Microbial Pathogens

Saturday, February 01 | 2:30PM - 4:30PM
Workshop 2: Host Defense to Microbial Pathogens
Room: Rio Grande Hall C-D

Speaker 2 of 5
Teunis B.H. Geijtenbeek, University of Amsterdam, Netherlands
Pathogens Target DC-Sign to Affect Immune Responses: Immune Escape Mechanisms

Saturday, February 01 | 2:30PM - 4:30PM
Workshop 2: Host Defense to Microbial Pathogens
Room: Rio Grande Hall C-D

Speaker 3 of 5
Carrie M. Rosenberger, Genentech, Inc., USA
Macrophage Signal Transduction Culminates in Elastase-Mediated Impairment of Intracellular Salmonella Typhimurium Replication

Saturday, February 01 | 2:30PM - 4:30PM
Workshop 2: Host Defense to Microbial Pathogens
Room: Rio Grande Hall C-D

Speaker 4 of 5
DeLisa Fairweather, Mayo Clinic, USA
IL-12Rbeta1 and TLR4 Signaling Increase IL-1beta and IL-18-Associated Myocarditis and Coxsackievirus Replication

Saturday, February 01 | 2:30PM - 4:30PM
Workshop 2: Host Defense to Microbial Pathogens
Room: Rio Grande Hall C-D

Speaker 5 of 5
Shuangping Shi, Cornell University Weill Medical College, USA
Genomic Approaches to Understand How the Macrophage Responds to Mycobacterium tuberculosis

Saturday, February 01 | 2:30PM - 4:30PM
Workshop 2: Innate Control of Infections
This session is from Adaptive Immune Responses
Room: Rio Grande Hall A-B

Speaker 1 of 10
* Christine A. Biron, Brown University, USA


Saturday, February 01 | 2:30PM - 4:30PM
Workshop 2: Innate Control of Infections
This session is from Adaptive Immune Responses
Room: Rio Grande Hall A-B

Speaker 2 of 10
* Alan Sher, NIAID, National Institutes of Health, USA


Saturday, February 01 | 2:30PM - 4:30PM
Workshop 2: Innate Control of Infections
This session is from Adaptive Immune Responses
Room: Rio Grande Hall A-B

Speaker 3 of 10
Stephanie Blandin, European Molecular Biology Laboratory, Germany
Functional Analysis of Immune Genes in the Mosquito, Anopheles gambiae


Saturday, February 01 | 2:30PM - 4:30PM
Workshop 2: Innate Control of Infections
This session is from Adaptive Immune Responses
Room: Rio Grande Hall A-B

Speaker 4 of 10
Sara R. Cherry, University of Pennsylvania, USA
Susceptibility to Infection is Sensitive to Modulation of the Endocytic Machinery in a Drosophila Model for Viral Pathogenesis


Saturday, February 01 | 2:30PM - 4:30PM
Workshop 2: Innate Control of Infections
This session is from Adaptive Immune Responses
Room: Rio Grande Hall A-B

Speaker 5 of 10
Thomas R. Hawn, University of Washington, USA
A Polymorphism in Human Toll-Like Receptor 5 Encodes a Variant that Abolishes Flagellin Signaling


Saturday, February 01 | 2:30PM - 4:30PM
Workshop 2: Innate Control of Infections
This session is from Adaptive Immune Responses
Room: Rio Grande Hall A-B

Speaker 6 of 10
Lena Alexopoulou, Center of Immunology Marseille-Luminy, France
Hyporesponsiveness to Vaccination with Borrelia burgdorferi Outer Surface Protein A (OspA) in Humans and TLR1-Deficient Mice


Saturday, February 01 | 2:30PM - 4:30PM
Workshop 2: Innate Control of Infections
This session is from Adaptive Immune Responses
Room: Rio Grande Hall A-B

Speaker 7 of 10
Daniela I. Verthelyi, U.S. Food and Drug Administration, USA
CpG ODN Act as Vaccine Adjuvants and Immunoprotective Agents in Healthy and Immunocompromised Primates


Saturday, February 01 | 2:30PM - 4:30PM
Workshop 2: Innate Control of Infections
This session is from Adaptive Immune Responses
Room: Rio Grande Hall A-B

Speaker 8 of 10
Rachelle Salomon, St. Jude Children's Research Hospital, USA
Characterization of the Biochemical Pathways Used by Type I Interferon to Signal for Immunoregulation


Saturday, February 01 | 2:30PM - 4:30PM
Workshop 2: Innate Control of Infections
This session is from Adaptive Immune Responses
Room: Rio Grande Hall A-B

Speaker 9 of 10
Brigitte G. Dorner, Washington University School of Medicine, USA
Coordinate Expression of Type 1 Cytokines by Natural Killer Cells during Murine Cytomegalovirus Infection


Saturday, February 01 | 2:30PM - 4:30PM
Workshop 2: Innate Control of Infections
This session is from Adaptive Immune Responses
Room: Rio Grande Hall A-B

Speaker 10 of 10
Mark T. Orr, Infectious Disease Research Institute, USA
Altered Immune Responses and Pathogenesis of Recombinant Herpes Simplex Virus with the Restored Ability to Down-Regulate MHC Class I in Mice


Saturday, February 01 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Bataan


Saturday, February 01 | 5:00PM - 7:00PM
Macrophage-Mediated Pathogenesis - Infectious Etiologies
Room: Rio Grande Hall C-D

Speaker 1 of 4
* Christopher L. Karp, Bill & Melinda Gates Foundation, USA

Saturday, February 01 | 5:00PM - 7:00PM
Macrophage-Mediated Pathogenesis - Infectious Etiologies
Room: Rio Grande Hall C-D

Speaker 2 of 4
Daniel J. Cua, Janssen Pharmaceutical Companies of Johnson & Johnson, USA
Differential Roles of IL-23 and IL-12 in Host Defense and Autoimmune
Inflammation


Saturday, February 01 | 5:00PM - 7:00PM
Macrophage-Mediated Pathogenesis - Infectious Etiologies
Room: Rio Grande Hall C-D

Speaker 3 of 4
Steven L. Kunkel, University of Michigan Medical School, USA
The Central Role of Chemokines in Linking Innate and Adaptive Immunity

Saturday, February 01 | 5:00PM - 7:00PM
Macrophage-Mediated Pathogenesis - Infectious Etiologies
Room: Rio Grande Hall C-D

Speaker 4 of 4
Frank Brombacher, International Center for Genetic Engineering and Biotechnology, South Africa
The Role of Alternatively Activated Macrophages in Infectious Diseases: Studies in Macrophage-Specific IL-4 Receptor-alpha Deficient Mice

Saturday, February 01 | 5:00PM - 7:00PM
NK Cells in Innate Immunity
This session is from Adaptive Immune Responses
Room: Rio Grande Hall A-B

Speaker 1 of 4
Christine A. Biron, Brown University, USA
Cytokine Interactions in Innate Responses to Viral Infections


Saturday, February 01 | 5:00PM - 7:00PM
NK Cells in Innate Immunity
This session is from Adaptive Immune Responses
Room: Rio Grande Hall A-B

Speaker 2 of 4
* Wayne M. Yokoyama, Washington University School of Medicine, USA
Specific Natural Killer Cell Responses to Viral Infection


Saturday, February 01 | 5:00PM - 7:00PM
NK Cells in Innate Immunity
This session is from Adaptive Immune Responses
Room: Rio Grande Hall A-B

Speaker 3 of 4
Julie Djeu, Moffitt Cancer Center, USA
Signal Transduction Controlling Lytic Function in Natural Killer Cells


Saturday, February 01 | 5:00PM - 7:00PM
NK Cells in Innate Immunity
This session is from Adaptive Immune Responses
Room: Rio Grande Hall A-B

Speaker 4 of 4
Eric O. Long, NIAID, National Institutes of Health, USA
Short Talk: The Vav1 - Rac1 Pathway is Central to Activation and Inhibition of NK Cell Cytotoxicity


Saturday, February 01 | 7:00PM - 8:00PM
Social Hour
Room: Bataan


Saturday, February 01 | 8:00PM - 10:00PM
Poster Session 2: Signal Transduction in Leukocytes
Room: Bataan


Sunday, February 02 | 7:00AM - 8:00AM
Breakfast
Room: Rio Grande Hall B-D


Sunday, February 02 | 8:00AM - 11:00AM
Innate Control of Intracellular Infections (Joint)
Room: Bataan

Speaker 1 of 4
Michel Desjardins, University of Montreal, Canada
Phagocytosis in the Post-Genomic Era

Sunday, February 02 | 8:00AM - 11:00AM
Innate Control of Intracellular Infections (Joint)
Room: Bataan

Speaker 2 of 4
* Emil R. Unanue, Washington University School of Medicine, USA
Stages in the Control of Listeria Infection

Sunday, February 02 | 8:00AM - 11:00AM
Innate Control of Intracellular Infections (Joint)
Room: Bataan

Speaker 3 of 4
Daniel A. Portnoy, University of California, Berkeley, USA
Why Listeria Monocytogenes is an Intracellular Pathogen

Sunday, February 02 | 8:00AM - 11:00AM
Innate Control of Intracellular Infections (Joint)
Room: Bataan

Speaker 4 of 4
David L. Sacks, NIAID, National Institutes of Health, USA
How Do Dendritic Cells Process Leishmania Antigens for Cross-Presentation to CD8+ T Cells?

Sunday, February 02 | 9:20AM - 9:40AM
Coffee Break
Room: Rio Grande Hall B-D


Sunday, February 02 | 2:00PM - 3:00PM
Poster Setup
Room: Bataan


Sunday, February 02 | 2:30PM - 4:30PM
Workshop 3: Innate and Adaptive Immune Responses
Room: Rio Grande Hall C-D

Speaker 1 of 5
* Evelyn A. Kurt-Jones, University of Massachusetts Medical School, USA
Role of Toll-Like Receptor 2 (TLR2) and CD14 in the Innate Immune Response to Bacteria and Viruses

Sunday, February 02 | 2:30PM - 4:30PM
Workshop 3: Innate and Adaptive Immune Responses
Room: Rio Grande Hall C-D

Speaker 2 of 5
Maria C. Jenmalm, DNAX Research Inc., USA
Regulation of Myeloid Cell Function through the CD200 Receptor

Sunday, February 02 | 2:30PM - 4:30PM
Workshop 3: Innate and Adaptive Immune Responses
Room: Rio Grande Hall C-D

Speaker 3 of 5
Matthias Hesse, Cornell University College of Veterinary Medicine, USA
Macrophage-Derived IL-10 Fails to Protect in Murine Schistosomiasis

Sunday, February 02 | 2:30PM - 4:30PM
Workshop 3: Innate and Adaptive Immune Responses
Room: Rio Grande Hall C-D

Speaker 4 of 5
Thomas J. Murphy, Ireland
Enhanced TLR Reactivity After Injury is Associated with Increased Mortality to a TLR4 Agonist

Sunday, February 02 | 2:30PM - 4:30PM
Workshop 3: Innate and Adaptive Immune Responses
Room: Rio Grande Hall C-D

Speaker 5 of 5
Dermot P. B. McGovern, Cedars Sinai Medical Center, USA
Innate Immunogenetics and Inflammatory Bowel Disease (IBD)

Sunday, February 02 | 2:30PM - 4:30PM
Workshop 3: Modulation of Adaptive Immunity by the Innate Im
mune System
This session is from Adaptive Immune Responses
Room: Rio Grande Hall A-B

Speaker 1 of 10
* Albert S. Bendelac, University of Chicago, USA


Sunday, February 02 | 2:30PM - 4:30PM
Workshop 3: Modulation of Adaptive Immunity by the Innate Im
mune System
This session is from Adaptive Immune Responses
Room: Rio Grande Hall A-B

Speaker 2 of 10
* Veronika Groh-Spies, Fred Hutchinson Cancer Research Center, USA


Sunday, February 02 | 2:30PM - 4:30PM
Workshop 3: Modulation of Adaptive Immunity by the Innate Im
mune System
This session is from Adaptive Immune Responses
Room: Rio Grande Hall A-B

Speaker 3 of 10
Bali Pulendran, Stanford University School of Medicine, USA
Different TLR Agonists Condition Dendritic Cells to Induce Distinct Classes of Immune Responses in vitro and in vivo


Sunday, February 02 | 2:30PM - 4:30PM
Workshop 3: Modulation of Adaptive Immunity by the Innate Im
mune System
This session is from Adaptive Immune Responses
Room: Rio Grande Hall A-B

Speaker 4 of 10
Laure Perrin-Cocon, Institut National de la Santé et de la Recherche Médicale, France
Lysophosphatidylcholine: An Endogenous Signal of Danger Promoting Mature Dendritic Cell Generation


Sunday, February 02 | 2:30PM - 4:30PM
Workshop 3: Modulation of Adaptive Immunity by the Innate Im
mune System
This session is from Adaptive Immune Responses
Room: Rio Grande Hall A-B

Speaker 5 of 10
Annie L. Neild, Yale University, USA
Legionella Reveal Novel Dendritic Cell Functions that Facilitate Selection of Antigens for MHC Class II Presentation


Sunday, February 02 | 2:30PM - 4:30PM
Workshop 3: Modulation of Adaptive Immunity by the Innate Im
mune System
This session is from Adaptive Immune Responses
Room: Rio Grande Hall A-B

Speaker 6 of 10
Rima Koka, University of Chicago, USA
Role of IL15Ralpha in the Peripheral Maintenance of NK Cells


Sunday, February 02 | 2:30PM - 4:30PM
Workshop 3: Modulation of Adaptive Immunity by the Innate Im
mune System
This session is from Adaptive Immune Responses
Room: Rio Grande Hall A-B

Speaker 7 of 10
Sigrid P. Dubois, NCI, National Institutes of Health, USA
Recycling and Trans-Presentation of IL-15 by IL-15Ralpha


Sunday, February 02 | 2:30PM - 4:30PM
Workshop 3: Modulation of Adaptive Immunity by the Innate Im
mune System
This session is from Adaptive Immune Responses
Room: Rio Grande Hall A-B

Speaker 8 of 10
Arin Betchen, University of California, San Francisco, USA
Immunologic Regulation of Airway Remodeling in Response to Chronic Infection with Mycoplasma pulmonis


Sunday, February 02 | 2:30PM - 4:30PM
Workshop 3: Modulation of Adaptive Immunity by the Innate Im
mune System
This session is from Adaptive Immune Responses
Room: Rio Grande Hall A-B

Speaker 9 of 10
Joseph D. Miller, Emory University, USA
CD/94/NKG2 Expression Does Not Inhibit Cytotoxic Function of Lymphocytic Choriomeningitis Virus-Specific CD8+ T Cells


Sunday, February 02 | 2:30PM - 4:30PM
Workshop 3: Modulation of Adaptive Immunity by the Innate Im
mune System
This session is from Adaptive Immune Responses
Room: Rio Grande Hall A-B

Speaker 10 of 10
Jin Seon S. Im, MD Anderson Cancer Center, USA
CD1d Dependent Activation of NK T Cells by Schwann Cells: Implications for Leprosy and Peripheral Neuropathy


Sunday, February 02 | 3:00PM - 10:00PM
Poster Viewing
Room: Bataan


Sunday, February 02 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Bataan


Sunday, February 02 | 5:00PM - 7:00PM
Pathogen Regulation of Macrophage Functions
Room: Rio Grande Hall C-D

Speaker 1 of 3
* Joel D. Ernst, University of California, San Francisco, USA
M. tuberculosis and Innate Inhibition of Adaptive Effector Responses

Sunday, February 02 | 5:00PM - 7:00PM
Pathogen Regulation of Macrophage Functions
Room: Rio Grande Hall C-D

Speaker 2 of 3
Christopher A. Hunter, University of Pennsylvania, USA
NF-kappaB: Master of danger?

Sunday, February 02 | 5:00PM - 7:00PM
Pathogen Regulation of Macrophage Functions
Room: Rio Grande Hall C-D

Speaker 3 of 3
Hidde L. Ploegh, Boston Children's Hospital, USA
Viral Inhibition of Antigen Presentation

Sunday, February 02 | 5:00PM - 7:00PM
The Interplay Between Innate and Adaptive Immunity I
This session is from Adaptive Immune Responses
Room: Rio Grande Hall A-B

Speaker 1 of 4
Polly Matzinger, NIAID, National Institutes of Health, USA
Conversations for Class Control


Sunday, February 02 | 5:00PM - 7:00PM
The Interplay Between Innate and Adaptive Immunity I
This session is from Adaptive Immune Responses
Room: Rio Grande Hall A-B

Speaker 2 of 4
* Albert S. Bendelac, University of Chicago, USA
Developmental Pathways of Innate-Like NKT Lymphocytes


Sunday, February 02 | 5:00PM - 7:00PM
The Interplay Between Innate and Adaptive Immunity I
This session is from Adaptive Immune Responses
Room: Rio Grande Hall A-B

Speaker 3 of 4
Marco Colonna, Washington University School of Medicine, USA
A Role for TREM Receptors in Myeloid Cell Development


Sunday, February 02 | 5:00PM - 7:00PM
The Interplay Between Innate and Adaptive Immunity I
This session is from Adaptive Immune Responses
Room: Rio Grande Hall A-B

Speaker 4 of 4
Bali Pulendran, Stanford University School of Medicine, USA
Short Talk: Impairment of Dendritic Cells and Adaptive Immunity by Anthrax Toxin, Lethal Factor


Sunday, February 02 | 7:00PM - 8:00PM
Social Hour
Room: Bataan


Sunday, February 02 | 8:00PM - 10:00PM
Poster Session 3: Macrophages as Regulatory Cells
Room: Bataan


Monday, February 03 | 7:00AM - 8:00AM
Breakfast
Room: Bataan


Monday, February 03 | 8:00AM - 11:00AM
Macrophage Development and Differentiation
Room: Rio Grande Hall C-D

Speaker 1 of 4
Harinder Singh, Cincinnati Children's Hospital Medical Center, USA
PU.1 and the Transcriptional Regulation of Macrophage Differentiation

Monday, February 03 | 8:00AM - 11:00AM
Macrophage Development and Differentiation
Room: Rio Grande Hall C-D

Speaker 2 of 4
* Siamon Gordon, Chang Gung University / University of Oxford, UK
Macrophage Receptors for Adhesion and Phagocytosis

Monday, February 03 | 8:00AM - 11:00AM
Macrophage Development and Differentiation
Room: Rio Grande Hall C-D

Speaker 3 of 4
Peter J. Murray, Max-Planck-Institut für Biochemie, Germany
Regulation of Macrophage Function by IL-10

Monday, February 03 | 8:00AM - 11:00AM
Macrophage Development and Differentiation
Room: Rio Grande Hall C-D

Speaker 4 of 4
Sabine Ehrt, Weill Cornell Medical College, USA
Transcriptional Responses of Mycobacterium tuberculosis Infected Macrophages: Roles of IFNgamma, iNOS, phox and MyD88

Monday, February 03 | 8:00AM - 11:00AM
The Interplay Between Innate and Adaptive Immunity II
This session is from Adaptive Immune Responses
Room: Rio Grande Hall A-B

Speaker 1 of 4
Veronika Groh-Spies, Fred Hutchinson Cancer Research Center, USA
Significance of the NKG2D Receptor and its Tumor-Associated Ligands


Monday, February 03 | 8:00AM - 11:00AM
The Interplay Between Innate and Adaptive Immunity II
This session is from Adaptive Immune Responses
Room: Rio Grande Hall A-B

Speaker 2 of 4
David H. Raulet, University of California, Berkeley, USA
Innate and Adaptive Immunity to Tumor Cells


Monday, February 03 | 8:00AM - 11:00AM
The Interplay Between Innate and Adaptive Immunity II
This session is from Adaptive Immune Responses
Room: Rio Grande Hall A-B

Speaker 3 of 4
* Philippa C. Marrack, HHMI/National Jewish Health, USA
Innate Immune Maintenance of T Helper Cells


Monday, February 03 | 8:00AM - 11:00AM
The Interplay Between Innate and Adaptive Immunity II
This session is from Adaptive Immune Responses
Room: Rio Grande Hall A-B

Speaker 4 of 4
Charles D. Surh, La Jolla Institute for Allergy and Immunology, USA
Homeostasis of Memory CD8+ T Cells Influenced by the Innate Immune System


Monday, February 03 | 9:20AM - 9:40AM
Coffee Break
Room: Bataan


Monday, February 03 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Bataan


Monday, February 03 | 5:00PM - 7:00PM
Macrophage Pathologies, Non-Infectious Etiologies
Room: Rio Grande Hall C-D

Speaker 1 of 3
Gregory A. Grabowski, Synageva BioPharma, USA
Lysosomal Storage Diseases and Macrophage Malfunction

Monday, February 03 | 5:00PM - 7:00PM
Macrophage Pathologies, Non-Infectious Etiologies
Room: Rio Grande Hall C-D

Speaker 2 of 3
Ajay Chawla, Merck and University of California, San Francisco, USA
PPARs, Macrophage Functions and Atherosclerosis

Monday, February 03 | 5:00PM - 7:00PM
Macrophage Pathologies, Non-Infectious Etiologies
Room: Rio Grande Hall C-D

Speaker 3 of 3
Ira Tabas, Columbia University, USA
The Pathobiology of the Cholesterol-Loaded Macrophage: How Induction of Apoptosis and ER Stress Pathways Become a Matter of Life and Death

Monday, February 03 | 5:00PM - 7:00PM
Innate Immunity in Human Disease Pathogenesis
This session is from Adaptive Immune Responses
Room: Rio Grande Hall A-B

Speaker 1 of 3
* Jean-Laurent Casanova, Rockefeller University, USA
Genetic Dissection of Immunity to Infection: The Human Model


Monday, February 03 | 5:00PM - 7:00PM
Innate Immunity in Human Disease Pathogenesis
This session is from Adaptive Immune Responses
Room: Rio Grande Hall A-B

Speaker 2 of 3
Foo Y. Liew, University of Glasgow, UK
The Role of Innate Cytokines in Inflammatory Arthritis


Monday, February 03 | 5:00PM - 7:00PM
Innate Immunity in Human Disease Pathogenesis
This session is from Adaptive Immune Responses
Room: Rio Grande Hall A-B

Speaker 3 of 3
Gabriel Nuñez, University of Michigan, USA
NOD2 and Crohn's Disease


Monday, February 03 | 7:00PM - 8:00PM
Social Hour
Room: Bataan


Monday, February 03 | 8:00PM - 11:00PM
Entertainment
Room: Bataan


Monday, February 03 | 8:00PM - 11:00PM
Cash Bar
Room: Bataan


Tuesday, February 04 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.