Web Desc
Membrane Proteins: Structure and Mechanism
joint with Frontiers of NMR in Molecular Biology VIII
Organizer(s): Joseph J. Falke and Douglas C. Rees
Date: February 04 - 10, 2003
Location: Taos Convention Center (meeting only), Taos, NM, USA
Sponsored in part by The Director's Sponsor Fund
Summary of Meeting:
The conference will feature presentations by established investigators and rising young stars in the rapidly expanding field of membrane proteins. Up to 30% of the human genome may encode transmembrane proteins and these proteins are the targets of most pharmaceuticals, yet progress toward a molecular understanding of membrane proteins has been slow until recent years. Now, however, sophisticated physical, chemical and biochemical methods are beginning to yield a structural and mechanistic view of the major functional subclasses, including transmembrane channels, receptors, transporters, and peripheral membrane proteins. The meeting is unique, since no other conference of this size brings together leading researchers focusing on all the major classes of membrane proteins to compare their latest findings and disseminate their newest experimental approaches.
Discounted Abstract Deadline: October 3 2002
Discounted Registration Deadline: December 4 2002
We gratefully acknowledge additional support for this conference from:

Cambridge Isotope Laboratories
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of General Medical Sciences (NIGMS)
Grant No. 1 R13 GM67188-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, February 04 | 3:00PM - 7:00PM
Registration
Room: Rio Grande Hall D


Tuesday, February 04 | 6:15PM - 7:15PM
Welcome
Room: Rio Grande Hall A-C


Tuesday, February 04 | 7:15PM - 7:30PM
Orientation
Room: Bataan


Tuesday, February 04 | 7:30PM - 8:30PM
Keynote Address (Joint)
Room: Bataan

Speaker 1 of 1
Kurt Wüthrich, ETH Zürich, Switzerland
NMR Techniques for Large Structures in Solution Applied to Membrane Proteins

Wednesday, February 05 | 7:00AM - 8:00AM
Breakfast
Room: Rio Grande Hall A-C


Wednesday, February 05 | 8:00AM - 11:15AM
NMR Studies of Membrane Proteins (Joint)
Room: Bataan

Speaker 6 of 6
Josep Rizo, University of Texas Southwestern Medical Center, USA
Short Talk: Differential Mechanisms of Action of Presynaptic C2-Domains

Wednesday, February 05 | 8:00AM - 11:15AM
NMR Studies of Membrane Proteins (Joint)
Room: Bataan

Speaker 5 of 6
Jun Qin, Lerner Research Institute, USA
Short Talk: Structural Basis of Integrin-Mediated Signaling in Cell Adhesion

Wednesday, February 05 | 8:00AM - 11:15AM
NMR Studies of Membrane Proteins (Joint)
Room: Bataan

Speaker 4 of 6
John H. Bushweller, University of Virginia, USA
Solution NMR Approaches to the Structure and Dynamics of Integral Membrane Proteins

Wednesday, February 05 | 8:00AM - 11:15AM
NMR Studies of Membrane Proteins (Joint)
Room: Bataan

Speaker 3 of 6
* Charles R. Sanders, Vanderbilt University School of Medicine, USA
A Structural Biophysics Approach to Membrane Protein Misfolding

Wednesday, February 05 | 8:00AM - 11:15AM
NMR Studies of Membrane Proteins (Joint)
Room: Bataan

Speaker 2 of 6
Timothy A. Cross, Florida State University, USA
Structural Features and Function of the M2 Proton Channel from Influenza A

Wednesday, February 05 | 8:00AM - 11:15AM
NMR Studies of Membrane Proteins (Joint)
Room: Bataan

Speaker 1 of 6
Lynmarie K. Thompson, University of Massachusetts, USA
Site-Directed Solid-State NMR Studies of Transmembrane Signaling

Wednesday, February 05 | 9:20AM - 9:40AM
Coffee Break
Room: Rio Grande Hall A-C


Wednesday, February 05 | 2:00PM - 3:00PM
Poster Setup
Room: Bataan


Wednesday, February 05 | 3:00PM - 10:00PM
Poster Viewing
Room: Bataan


Wednesday, February 05 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Bataan


Wednesday, February 05 | 5:00PM - 7:00PM
Computational/NMR Interface in Protein Structure Determinati
on
This session is from Frontiers of NMR

Room: Rio Grande Hall A-B

Speaker 4 of 5
Michael Nilges, Institut Pasteur, France
Inferential Structure Determination


Wednesday, February 05 | 5:00PM - 7:00PM
Computational/NMR Interface in Protein Structure Determinati
on
This session is from Frontiers of NMR

Room: Rio Grande Hall A-B

Speaker 3 of 5
Jeffrey Skolnick, Georgia Institute of Technology, USA
Prediction of Protein Structure and Function on a Genomic Scale


Wednesday, February 05 | 5:00PM - 7:00PM
Computational/NMR Interface in Protein Structure Determinati
on
This session is from Frontiers of NMR

Room: Rio Grande Hall A-B

Speaker 2 of 5
David A. Case, Rutgers University, USA
What Can We Learn About Hydrogen Bonding from Biomolecular NMR?


Wednesday, February 05 | 5:00PM - 7:00PM
Computational/NMR Interface in Protein Structure Determinati
on
This session is from Frontiers of NMR

Room: Rio Grande Hall A-B

Speaker 1 of 5
* Carol B. Post, Purdue University, USA


Wednesday, February 05 | 5:00PM - 7:15PM
Membrane Protein Translocation, Folding and Assembly
Room: Rio Grande Hall D

Speaker 5 of 5
Christine A. Hrycyna, Purdue University, USA
Short Talk: Molecular Mechanisms of Ras Isoprenylcysteine Carboxyl Methyltransferase (ICMT)

Wednesday, February 05 | 5:00PM - 7:15PM
Membrane Protein Translocation, Folding and Assembly
Room: Rio Grande Hall D

Speaker 4 of 5
Diane M. Papazian, University of California, Los Angeles, USA
Conformational States of Voltage Gated Channels

Wednesday, February 05 | 5:00PM - 7:15PM
Membrane Protein Translocation, Folding and Assembly
Room: Rio Grande Hall D

Speaker 3 of 5
Avram M. Slovic, Columbia University, USA
Short Talk: Computational Methods for the Design of Water-Soluble Membrane Proteins

Wednesday, February 05 | 5:00PM - 7:15PM
Membrane Protein Translocation, Folding and Assembly
Room: Rio Grande Hall D

Speaker 2 of 5
Linda L. Randall, University of Missouri, USA
Interaction between Protein Chaperones during Export in E. coli

Wednesday, February 05 | 5:00PM - 7:15PM
Membrane Protein Translocation, Folding and Assembly
Room: Rio Grande Hall D

Speaker 1 of 5
* Donald M. Engelman, Yale University, USA
Stability and Specificity in Membrane Protein Folding

Wednesday, February 05 | 5:00PM - 7:00PM
Computational/NMR Interface in Protein Structure Determinati
on
This session is from Frontiers of NMR

Room: Rio Grande Hall A-B

Speaker 5 of 5
Alexandre M.J.J. Bonvin, Utrecht University, Netherlands
Short Talk: HADDOCK: A Protein-Protein Docking Approach Based on Biochemical or Biophysical Information


Wednesday, February 05 | 7:00PM - 8:00PM
Social Hour
Room: Bataan


Wednesday, February 05 | 8:00PM - 10:00PM
Poster Session 1: Channels
Room: Bataan


Thursday, February 06 | 7:00AM - 8:00AM
Breakfast
Room: Bataan


Thursday, February 06 | 8:00AM - 11:00AM
Ion Channels I
Room: Rio Grande Hall D

Speaker 1 of 6
* Douglas C. Rees, California Institute of Technology, USA

Thursday, February 06 | 8:00AM - 11:00AM
Ion Channels I
Room: Rio Grande Hall D

Speaker 2 of 6
Randal B. Bass, California Institute of Technology, USA
Crystal Structure of MscS, a Voltage- and Mechano-Gated Channel

Thursday, February 06 | 8:00AM - 11:00AM
Ion Channels I
Room: Rio Grande Hall D

Speaker 3 of 6
Sergei I. Sukharev, University of Maryland, USA
Mechanistic Studies of the MscL Mechanosensitive Channel

Thursday, February 06 | 8:00AM - 11:00AM
Ion Channels I
Room: Rio Grande Hall D

Speaker 4 of 6
Eduardo A. Perozo, University of Chicago, USA
Large-Scale Rearrangements in Mechanosensitive Channel Gating

Thursday, February 06 | 8:00AM - 11:00AM
Ion Channels I
Room: Rio Grande Hall D

Speaker 5 of 6
Merritt Maduke, Stanford University, USA
Probing the Mechanisms of 'ClC' Chloride Channels

Thursday, February 06 | 8:00AM - 11:00AM
Ion Channels I
Room: Rio Grande Hall D

Speaker 6 of 6
Kenneth H. Lundstrom, BioXtal, Inc., Switzerland
Short Talk: MePNet: Structural Genomics Initiative on Membrane Proteins

Thursday, February 06 | 8:00AM - 11:15AM
Large Proteins and Large Protein Assemblies
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 1 of 8
* Angela M. Gronenborn, University of Pittsburgh, USA


Thursday, February 06 | 8:00AM - 11:15AM
Large Proteins and Large Protein Assemblies
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 2 of 8
Gerhard Wagner, Harvard Medical School, USA
Structures and Interactions of Proteins in Eukaryotic Translation Initiation


Thursday, February 06 | 8:00AM - 11:15AM
Large Proteins and Large Protein Assemblies
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 3 of 8
Jacob Schaefer, Washington University, USA
Cell-Wall Complexes of Vancomycins in Whole Cells of S. aureus


Thursday, February 06 | 8:00AM - 11:15AM
Large Proteins and Large Protein Assemblies
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 4 of 8
Brian D. Sykes, University of Alberta, Canada
Calcium Regulatory Proteins: From Solution to Intact Muscle Fibers


Thursday, February 06 | 8:00AM - 11:15AM
Large Proteins and Large Protein Assemblies
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 5 of 8
Lewis E. Kay, University of Toronto, Canada
Domain Orientations in Large Proteins


Thursday, February 06 | 8:00AM - 11:15AM
Large Proteins and Large Protein Assemblies
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 6 of 8
Richard W. Kriwacki, St. Jude Children's Research Hospital, USA
Solution NMR Studies of Cell Cycle Regulatory Complexes


Thursday, February 06 | 8:00AM - 11:15AM
Large Proteins and Large Protein Assemblies
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 7 of 8
Tomas Åkerud, AstraZeneca, Sweden
Short Talk: Oligomerisation and Intramolecular Dynamics of Low Molecular Weight Protein Tyrosine Phosphatase Studied by NMR and Hydrodynamic Calculations


Thursday, February 06 | 8:00AM - 11:15AM
Large Proteins and Large Protein Assemblies
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 8 of 8
Paul B. Card, University of Texas Southwestern Medical Center, USA
Short Talk: PAS Domain Mediated Signaling in the Hypoxia Response


Thursday, February 06 | 9:20AM - 9:40AM
Coffee Break
Room: Bataan


Thursday, February 06 | 11:00AM - 1:00PM
Poster Setup
Room: Bataan


Thursday, February 06 | 1:00PM - 10:00PM
Poster Viewing
Room: Bataan


Thursday, February 06 | 2:30PM - 4:30PM
Workshop in Honor of Sunney Chan (Joint)
Room: Rio Grande Hall A-C

Speaker 1 of 6
* Joseph J. Falke, University of Colorado, USA

Thursday, February 06 | 2:30PM - 4:30PM
Workshop in Honor of Sunney Chan (Joint)
Room: Rio Grande Hall A-C

Speaker 2 of 6
* James H. Prestegard, University of Georgia, USA

Thursday, February 06 | 2:30PM - 4:30PM
Workshop in Honor of Sunney Chan (Joint)
Room: Rio Grande Hall A-C

Speaker 3 of 6
Lynmarie K. Thompson, University of Massachusetts, USA
Introduction

Thursday, February 06 | 2:30PM - 4:30PM
Workshop in Honor of Sunney Chan (Joint)
Room: Rio Grande Hall A-C

Speaker 4 of 6
Gary Brudvig, Yale University, USA
Magnetic Resonance Studies of Transmembrane Electron Transfer

Thursday, February 06 | 2:30PM - 4:30PM
Workshop in Honor of Sunney Chan (Joint)
Room: Rio Grande Hall A-C

Speaker 5 of 6
David F. Blair, University of Utah, USA
Membrane Protein Structures in the Bacterial Rotary Motor

Thursday, February 06 | 2:30PM - 4:30PM
Workshop in Honor of Sunney Chan (Joint)
Room: Rio Grande Hall A-C

Speaker 6 of 6
Hiep-Hoa T. Nguyen, TransMembrane Biosciences, USA
Methods for Overexpression of Membrane Proteins

Thursday, February 06 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Bataan


Thursday, February 06 | 5:00PM - 7:15PM
Receptors I
Room: Rio Grande Hall D

Speaker 1 of 5
Joseph J. Falke, University of Colorado, USA
Receptor Transmembrane Signaling and Kinase Regulation

Thursday, February 06 | 5:00PM - 7:15PM
Receptors I
Room: Rio Grande Hall D

Speaker 2 of 5
* James A. Wells, University of California, San Francisco, USA
Site-Directed Drug Discovery at Signaling Interfaces

Thursday, February 06 | 5:00PM - 7:15PM
Receptors I
Room: Rio Grande Hall D

Speaker 3 of 5
K. Christopher Garcia, Stanford University School of Medicine, USA
New Structural Paradigms in Receptor/Ligand Interactions

Thursday, February 06 | 5:00PM - 7:15PM
Receptors I
Room: Rio Grande Hall D

Speaker 4 of 5
Nagarajan Vaidehi, City of Hope National Medical Center, USA
Short Talk: Structure and Function for G Protein-Coupled Receptors

Thursday, February 06 | 5:00PM - 7:15PM
Receptors I
Room: Rio Grande Hall D

Speaker 5 of 5
Reinhard Grisshammer, NIH/NINDS, USA
Short Talk: Expression and Purification of G-Protein-Coupled Receptors for Structure Determination

Thursday, February 06 | 5:00PM - 7:00PM
Structural Genomics - New Experimental Approaches. Session
Sponsored in part by Bruker BioSpin Corporation.
This session is from Frontiers of NMR

Room: Rio Grande Hall A-B

Speaker 1 of 5
* Gerhard Wagner, Harvard Medical School, USA


Thursday, February 06 | 5:00PM - 7:00PM
Structural Genomics - New Experimental Approaches. Session
Sponsored in part by Bruker BioSpin Corporation.
This session is from Frontiers of NMR

Room: Rio Grande Hall A-B

Speaker 2 of 5
Gaetano Thomas Montelione, Rutgers University, USA
Protein Sample Production Technologies for Large-Scale Structural Genomics


Thursday, February 06 | 5:00PM - 7:00PM
Structural Genomics - New Experimental Approaches. Session
Sponsored in part by Bruker BioSpin Corporation.
This session is from Frontiers of NMR

Room: Rio Grande Hall A-B

Speaker 3 of 5
Cheryl Arrowsmith, University of Toronto, Canada
Structural Proteomics: A Tool for Annotation of the Genome


Thursday, February 06 | 5:00PM - 7:00PM
Structural Genomics - New Experimental Approaches. Session
Sponsored in part by Bruker BioSpin Corporation.
This session is from Frontiers of NMR

Room: Rio Grande Hall A-B

Speaker 4 of 5
James H. Prestegard, University of Georgia, USA
Residual Dipolar Couplings: A Basis for Structure Determination and Classification


Thursday, February 06 | 5:00PM - 7:00PM
Structural Genomics - New Experimental Approaches. Session
Sponsored in part by Bruker BioSpin Corporation.
This session is from Frontiers of NMR

Room: Rio Grande Hall A-B

Speaker 5 of 5
Wolfgang Peti, University of Arizona, USA
Short Talk: NMR for Structural Genomics: The Thermotoga maritima Proteome


Thursday, February 06 | 7:00PM - 8:00PM
Social Hour
Room: Bataan


Thursday, February 06 | 8:00PM - 10:00PM
Poster Session 2: Receptors
Room: Bataan


Friday, February 07 | 7:00AM - 8:00AM
Breakfast
Room: Bataan


Friday, February 07 | 8:00AM - 11:00AM
Transporters I
Room: Rio Grande Hall D

Speaker 1 of 5
* H. Ronald Kaback, University of California, Los Angeles, USA
Structure and Mechanism of Lac Permease

Friday, February 07 | 8:00AM - 11:00AM
Transporters I
Room: Rio Grande Hall D

Speaker 2 of 5
Geoffrey Chang, The Scripps Research Institute, USA
Structural Analysis of MDR-ABC Transporter

Friday, February 07 | 8:00AM - 11:00AM
Transporters I
Room: Rio Grande Hall D

Speaker 3 of 5
Nancy Carrasco, Albert Einstein College of Medicine, USA
The Sodium/Iodide Symporter (NIS): Characterization, Regulation and Medical Significance

Friday, February 07 | 8:00AM - 11:00AM
Transporters I
Room: Rio Grande Hall D

Speaker 4 of 5
Sunney Ignatius Chan, California Institute of Technology, USA
Structure and Mechanism of Membrane-Bound Electron Transport and Energy Transducing Enzymes: Old Tricks and New Strategies

Friday, February 07 | 8:00AM - 11:00AM
Transporters I
Room: Rio Grande Hall D

Speaker 5 of 5
Kaspar P. Locher, ETH - Zürich, Switzerland
Short Talk: Crystal Structure of a Bacterial ABC Transporter

Friday, February 07 | 8:00AM - 11:15AM
New Methods in NMR
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 1 of 7
* Brian D. Sykes, University of Alberta, Canada


Friday, February 07 | 8:00AM - 11:15AM
New Methods in NMR
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 2 of 7
Stanley J. Opella, University of California, San Diego, USA
New NMR Methods for Membrane Proteins


Friday, February 07 | 8:00AM - 11:15AM
New Methods in NMR
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 3 of 7
Robert G. Griffin, Massachusetts Institute of Technology, USA
Amyloid and Membrane Protein Structure Determination with Dynamic Nuclear Polarization and MAS Dipolar Recoupling


Friday, February 07 | 8:00AM - 11:15AM
New Methods in NMR
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 4 of 7
Teresa Carlomagno, Universität Hannover, Germany
Cross-Correlated Relaxation Rates: Measuring Torsion Angles in Carbon Chains of Proteins and Protein-Ligand Complexes


Friday, February 07 | 8:00AM - 11:15AM
New Methods in NMR
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 5 of 7
Ad Bax, NIDDK, National Institutes of Health, USA
Shortcuts in NMR Structure Determination


Friday, February 07 | 8:00AM - 11:15AM
New Methods in NMR
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 6 of 7
Alfred Redfield, Brandeis University, USA
Short Talk: Field-Cycling Studies of Diverse Biopolymers by Field Cycling in a Shared Instrument: Screening of Binding?


Friday, February 07 | 8:00AM - 11:15AM
New Methods in NMR
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 7 of 7
John L. Markley, University of Wisconsin-Madison, USA
Short Talk: Cell-Free Preparation of Proteins for NMR Spectroscopy


Friday, February 07 | 9:20AM - 9:40AM
Coffee Break
Room: Bataan


Friday, February 07 | 11:00AM - 1:00PM
Poster Setup
Room: Bataan


Friday, February 07 | 1:00PM - 10:00PM
Poster Viewing
Room: Bataan


Friday, February 07 | 2:30PM - 4:30PM
Workshop on Partially Aligned Molecules
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 1 of 9
* Ad Bax, NIDDK, National Institutes of Health, USA


Friday, February 07 | 2:30PM - 4:30PM
Workshop on Partially Aligned Molecules
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 2 of 9
Gianluigi Veglia, University of Minnesota, USA
Residual Dipolar Couplings for Use in NMR Structure Determination of Membrane Proteins


Friday, February 07 | 2:30PM - 4:30PM
Workshop on Partially Aligned Molecules
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 3 of 9
Ronaldo M. Mohana-Borges, Federal University of Rio de Janeiro (UFRJ), Brazil
Mapping the Topology of Unfolded and Partially Folded Proteins by Residual Dipolar Couplings


Friday, February 07 | 2:30PM - 4:30PM
Workshop on Partially Aligned Molecules
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 4 of 9
Markus Zweckstetter, Max-Planck Institute for Biophysical Chemistry / DZNE, Germany
Rapid Characterization of Protein Assemblies using NMR Derived Molecular Alignment


Friday, February 07 | 2:30PM - 4:30PM
Workshop on Partially Aligned Molecules
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 5 of 9
Yufeng Wei, Seton Hall University, USA
Structure of the Anti-Apoptotic Protein PEA-15 Using Residual Dipolar Coupling Measurements


Friday, February 07 | 2:30PM - 4:30PM
Workshop on Partially Aligned Molecules
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 6 of 9
Frédéric H.T. Allain, ETH Zurich, Switzerland
Solution Structures of Two RNA Substrates for Editing


Friday, February 07 | 2:30PM - 4:30PM
Workshop on Partially Aligned Molecules
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 7 of 9
Justin Wu, Ohio State University, USA
Solution Structure of gS-crystallin from Residual Dipolar Couplings


Friday, February 07 | 2:30PM - 4:30PM
Workshop on Partially Aligned Molecules
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 8 of 9
Tobias Sebastian Ulmer, NIDDK, National Institutes of Health, USA
Refinement of the Backbone Geometry of GB3 Using Dipolar Couplings. Insight into the Proton Positions


Friday, February 07 | 2:30PM - 4:30PM
Workshop on Partially Aligned Molecules
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 9 of 9
Mirko Hennig, The Scripps Research Institute, USA
Labeling Methodology and 19F NMR of Fluoropyrimidine Substituted RNA


Friday, February 07 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Bataan


Friday, February 07 | 5:00PM - 7:15PM
Ion Channels II
Room: Rio Grande Hall D

Speaker 1 of 4
* Richard W. Aldrich, Stanford University, USA
Conformational Changes and Allosteric Interactions in Potassium Channels Gated by Voltage and Calcium

Friday, February 07 | 5:00PM - 7:15PM
Ion Channels II
Room: Rio Grande Hall D

Speaker 2 of 4
Youxing Jiang, University of Texas Southwestern Medical Center, USA
Structure and Mechanism of a Calcium-Gated Potassium Channel

Friday, February 07 | 5:00PM - 7:15PM
Ion Channels II
Room: Rio Grande Hall D

Speaker 3 of 4
Francisco Bezanilla, University of Chicago, USA
Stuctural Rearrangement during Voltage Gating

Friday, February 07 | 5:00PM - 7:15PM
Ion Channels II
Room: Rio Grande Hall D

Speaker 4 of 4
Michael C. Wiener, University of Virginia, USA
Short Talk: Substrate-Induced Transmembrane Signaling in the Outer-Membrane Cobalamin Transporter BtuB

Friday, February 07 | 5:00PM - 7:00PM
Protein Modifications and Interactions
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 1 of 4
* Erik R. P. Zuiderweg, University of Michigan, USA


Friday, February 07 | 5:00PM - 7:00PM
Protein Modifications and Interactions
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 2 of 4
David E. Wemmer, University of California, Berkeley, USA
Phosphoaspartate Signaling and Enzymology


Friday, February 07 | 5:00PM - 7:00PM
Protein Modifications and Interactions
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 3 of 4
Angela M. Gronenborn, University of Pittsburgh, USA
A Protein Contortionist: Core Mutations Switch Monomeric Protein GB1 into Different Multimers


Friday, February 07 | 5:00PM - 7:00PM
Protein Modifications and Interactions
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 4 of 4
David H. Live, University of Georgia, USA
Short Talk: Structure and Dynamics of Mucin Motifs


Friday, February 07 | 7:00PM - 8:00PM
Social Hour
Room: Bataan


Friday, February 07 | 8:00PM - 10:00PM
Poster Session 3: Interfacial Membrane Proteins and Transpor
ters
Room: Bataan


Saturday, February 08 | 7:00AM - 8:00AM
Breakfast
Room: Bataan


Saturday, February 08 | 8:00AM - 11:00AM
Receptors II
Room: Rio Grande Hall D

Speaker 1 of 5
* Wayne L. Hubbell, University of California, Los Angeles, USA
Mechanism of Rhodopsin Signaling

Saturday, February 08 | 8:00AM - 11:00AM
Receptors II
Room: Rio Grande Hall D

Speaker 2 of 5
Brian K. Kobilka, Stanford University School of Medicine, USA
Ligand-Induced Conformational Changes in the Beta2 Adrenoceptor

Saturday, February 08 | 8:00AM - 11:00AM
Receptors II
Room: Rio Grande Hall D

Speaker 3 of 5
Jonathan A. Javitch, Columbia University, USA
Mapping the Surface of the Binding-Site Crevice of the Dopamine D2 Receptor: Clues to the Structural Bases of Pharmacological Specificity and to the Identification of a Symmetrical Homodimer Interface

Saturday, February 08 | 8:00AM - 11:00AM
Receptors II
Room: Rio Grande Hall D

Speaker 4 of 5
Mark Yeager, University of Virginia School of Medicine, USA
3D Structure of Membrane Proteins

Saturday, February 08 | 8:00AM - 11:00AM
Receptors II
Room: Rio Grande Hall D

Speaker 5 of 5
Eric J. Hustedt, Vanderbilt University, USA
Short Talk: New Models and Methods for the Analysis of Dipolar Coupling Between Spin Labels

Saturday, February 08 | 8:00AM - 11:15AM
Small Molecule-Macromolecule Interactions and Drug Design
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 1 of 7
* David E. Wemmer, University of California, Berkeley, USA


Saturday, February 08 | 8:00AM - 11:15AM
Small Molecule-Macromolecule Interactions and Drug Design
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 2 of 7
Jonathan M. Moore, Vertex Pharmaceuticals Incorporated, USA
NMR-Based Strategies in Drug Discovery


Saturday, February 08 | 8:00AM - 11:15AM
Small Molecule-Macromolecule Interactions and Drug Design
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 3 of 7
Bernd Meyer, University of Hamburg, Germany
STD-NMR to Screen Libraries and to Characterize Ligand Binding to Receptors


Saturday, February 08 | 8:00AM - 11:15AM
Small Molecule-Macromolecule Interactions and Drug Design
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 4 of 7
Wolfgang Jahnke, Novartis Institutes for BioMedical Research, Switzerland
New Methods and Applications of NMR in Drug Discovery


Saturday, February 08 | 8:00AM - 11:15AM
Small Molecule-Macromolecule Interactions and Drug Design
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 5 of 7
Philip J. Hajduk, Abbott Laboratories, USA
NMR in Drug Discovery and Design


Saturday, February 08 | 8:00AM - 11:15AM
Small Molecule-Macromolecule Interactions and Drug Design
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 6 of 7
Andrew J. Benie, Novo Nordisk A/S, Denmark
Short Talk: NMR Studies of the Binding of Ligands to a Native Rhinovirus


Saturday, February 08 | 8:00AM - 11:15AM
Small Molecule-Macromolecule Interactions and Drug Design
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 7 of 7
John P. Marino, National Institute of Standards and Technology, USA
Short Talk: Using 19F NMR to Screen Small Molecules that Target
a Soluble Mimic of the Light-Activated GPCR Rhodopsin




Saturday, February 08 | 9:20AM - 9:40AM
Coffee Break
Room: Bataan


Saturday, February 08 | 11:00AM - 1:00PM
Poster Setup
Room: Bataan


Saturday, February 08 | 1:00PM - 10:00PM
Poster Viewing
Room: Bataan


Saturday, February 08 | 2:30PM - 4:30PM
Workshop on Automation of Data Analysis
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 1 of 8
* Michael Nilges, Institut Pasteur, France


Saturday, February 08 | 2:30PM - 4:30PM
Workshop on Automation of Data Analysis
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 2 of 8
Xiaolian Gao, University of Houston, USA
Chemical Shift Correlated Protein Data Base (CSC-PDB) for Automated Protein Structure Determination


Saturday, February 08 | 2:30PM - 4:30PM
Workshop on Automation of Data Analysis
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 3 of 8
Thomas Szyperski, SUNY at Buffalo, USA
GFT NMR: New Methodology to Rapidly Obtain Precise High-Dimensional Spectral Information


Saturday, February 08 | 2:30PM - 4:30PM
Workshop on Automation of Data Analysis
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 4 of 8
Pei Zhou, Duke University Medical Center, USA
A Novel Exhaustive Search Algorithm for the Computer-Assisted Backbone Resonance Assignment from NMR Data


Saturday, February 08 | 2:30PM - 4:30PM
Workshop on Automation of Data Analysis
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 5 of 8
Sven G. Hyberts, Harvard Medical School, USA
IBIS, a User-Interactive Tool for Automated Sequential Assignment of Protein Spectra from Triple-Resonance Experiments


Saturday, February 08 | 2:30PM - 4:30PM
Workshop on Automation of Data Analysis
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 6 of 8
Torsten Herrmann, ETH - Zurich, Switzerland
Automated NOESY Peak Picking and NOE Assignment with the New Software RADAR


Saturday, February 08 | 2:30PM - 4:30PM
Workshop on Automation of Data Analysis
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 7 of 8
Jeffrey C. Hoch, Rowland Institute, USA
Bayesian Restraint Potentials for Consistent Inference of Biomolecular Structure from NMR Data


Saturday, February 08 | 2:30PM - 4:30PM
Workshop on Automation of Data Analysis
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 8 of 8
Eldon L. Ulrich, University of Wisconsin-Madison, USA
BioMagResBank (BMRB)


Saturday, February 08 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Bataan


Saturday, February 08 | 5:00PM - 7:00PM
Transporters II and Interfacial Proteins I
Room: Rio Grande Hall D

Speaker 1 of 5
David S. Cafiso, University of Virginia, USA
Molecular Mechanism of Outer-Membrane Transport Studied using Site-Directed Spin Labeling

Saturday, February 08 | 5:00PM - 7:00PM
Transporters II and Interfacial Proteins I
Room: Rio Grande Hall D

Speaker 2 of 5
* Barry Honig, Columbia University / HHMI, USA
Computational Studies of the Interaction of Proteins and Peptides with Membrane Interfaces

Saturday, February 08 | 5:00PM - 7:00PM
Transporters II and Interfacial Proteins I
Room: Rio Grande Hall D

Speaker 3 of 5
William A. Cramer, Purdue University, USA
Import of Colicin E3 across the Outer Membrane: On the Role of the Coiled-Coil and a Two Receptor Mechanism

Saturday, February 08 | 5:00PM - 7:00PM
Transporters II and Interfacial Proteins I
Room: Rio Grande Hall D

Speaker 4 of 5
Nathan J. Malmberg, University of Colorado Boulder, USA
and

Saturday, February 08 | 5:00PM - 7:00PM
Transporters II and Interfacial Proteins I
Room: Rio Grande Hall D

Speaker 5 of 5
Susy C. Kohout, University of Colorado, Boulder, USA
Short Talk: EPR Analysis of Calcium-Activated C2 Domains Defines Membrane Docking and Penetration

Saturday, February 08 | 5:00PM - 7:00PM
Nucleic Acids and Protein-Nucleic Acid Complexes
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 1 of 5
* Harald Schwalbe, University of Frankfurt, Germany


Saturday, February 08 | 5:00PM - 7:00PM
Nucleic Acids and Protein-Nucleic Acid Complexes
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 2 of 5
Joseph D. Puglisi, Stanford University, USA
NMR Investigations of Large RNAs


Saturday, February 08 | 5:00PM - 7:00PM
Nucleic Acids and Protein-Nucleic Acid Complexes
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 3 of 5
Arthur Pardi, University of Colorado, Boulder, USA
Structure, Dynamics and Stability of tRNAs in Solution


Saturday, February 08 | 5:00PM - 7:00PM
Nucleic Acids and Protein-Nucleic Acid Complexes
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 4 of 5
Juli Feigon, University of California, Los Angeles, USA
Biophysical Studies of Telomerase RNA Structure and Mutations Linked to Disease


Saturday, February 08 | 5:00PM - 7:00PM
Nucleic Acids and Protein-Nucleic Acid Complexes
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 5 of 5
Robert T. Clubb, University of California, Los Angeles, USA
Short Talk: Reading the Major Groove Through Loop Immobilization: Structure and Dynamics of the ARID-DNA Complex


Saturday, February 08 | 7:00PM - 8:00PM
Social Hour
Room: Bataan


Saturday, February 08 | 8:00PM - 10:00PM
Poster Session 4: Transporters
Room: Bataan


Sunday, February 09 | 7:00AM - 8:00AM
Breakfast
Room: Bataan


Sunday, February 09 | 8:00AM - 11:00AM
Interfacial Proteins II
Room: Rio Grande Hall D

Speaker 1 of 5
Lawrence S. Shapiro, Columbia University, USA
Cadherins and Cell-Cell Adhesion: Structure-Function Analysis

Sunday, February 09 | 8:00AM - 11:00AM
Interfacial Proteins II
Room: Rio Grande Hall D

Speaker 2 of 5
* Deborah E. Leckband, University of Illinois at Urbana-Champaign, USA
Novel Mechanisms of Cell Adhesion

Sunday, February 09 | 8:00AM - 11:00AM
Interfacial Proteins II
Room: Rio Grande Hall D

Speaker 3 of 5
Michael S. Wolfe, Brigham and Women's Hospital, Harvard Medical School, USA
Gamma-Secretase: Portrait of an Intramembrane Protease Complex

Sunday, February 09 | 8:00AM - 11:00AM
Interfacial Proteins II
Room: Rio Grande Hall D

Speaker 4 of 5
Michael J. Overduin, University of Alberta, Canada
Depth of FYVE Domain Membrane Insertione and DIX Domain's Actin and Vesicular Locallization

Sunday, February 09 | 8:00AM - 11:00AM
Interfacial Proteins II
Room: Rio Grande Hall D

Speaker 5 of 5
Christian F.W. Becker, Gryphon Therapeutics, USA
Short Talk: Solubilization of Tb_MscL by Covalent Detergent Modification

Sunday, February 09 | 8:00AM - 11:15AM
Motions in Proteins and Nucleic Acids
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 1 of 7
* James H. Prestegard, University of Georgia, USA


Sunday, February 09 | 8:00AM - 11:15AM
Motions in Proteins and Nucleic Acids
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 2 of 7
Erik R. P. Zuiderweg, University of Michigan, USA
A Role of Dynamics in Allosteric Proteins


Sunday, February 09 | 8:00AM - 11:15AM
Motions in Proteins and Nucleic Acids
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 3 of 7
A. Joshua Wand, University of Pennsylvania, USA
Protein Dynamics and Thermodynamics: A View Emerging from NMR Relaxation


Sunday, February 09 | 8:00AM - 11:15AM
Motions in Proteins and Nucleic Acids
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 4 of 7
David P. Cistola, Washington University School of Medicine, USA
Functionally Relevant Slow Motions in Proteins


Sunday, February 09 | 8:00AM - 11:15AM
Motions in Proteins and Nucleic Acids
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 5 of 7
Harald Schwalbe, University of Frankfurt, Germany
Nucleic Acids in Motion


Sunday, February 09 | 8:00AM - 11:15AM
Motions in Proteins and Nucleic Acids
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 6 of 7
Dorothee Kern, Brandeis University, HHMI, USA
Short Talk: Enzymes in Action in the NMR Tube- Protein Dynamics and Reaction Trajectories in Enzyme Catalysis


Sunday, February 09 | 8:00AM - 11:15AM
Motions in Proteins and Nucleic Acids
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 7 of 7
Ernesto J. Fuentes, University of Iowa, USA
Short Talk: Dynamic Response of a PDZ Domain Protein to Peptide Binding


Sunday, February 09 | 9:00AM - 9:20AM
Coffee Break
Room: Bataan


Sunday, February 09 | 5:00PM - 7:00PM
Computational Analysis of Motions in Proteins
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 1 of 4
* A. Joshua Wand, University of Pennsylvania, USA


Sunday, February 09 | 5:00PM - 7:00PM
Computational Analysis of Motions in Proteins
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 2 of 4
Carol B. Post, Purdue University, USA
Dengne Virus Capsid Protein


Sunday, February 09 | 5:00PM - 7:00PM
Computational Analysis of Motions in Proteins
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 3 of 4
Ronald Levy, Stanford University, USA
Recent Studies of Protein Structure and Motions


Sunday, February 09 | 5:00PM - 7:00PM
Computational Analysis of Motions in Proteins
This session is from Frontiers of NMR
Room: Rio Grande Hall A-B

Speaker 4 of 4
Lennart Nilsson, Karolinska Institute, Sweden
Short Talk: Protein Dynamics, Correlations and Stability


Sunday, February 09 | 7:00PM - 8:00PM
Social Hour
Room: Bataan


Sunday, February 09 | 8:00PM - 11:00PM
Entertainment
Room: Bataan


Sunday, February 09 | 8:00PM - 11:00PM
Cash Bar
Room: Bataan


Monday, February 10 | 10:26AM - 10:26AM
Departure


*Session Chair.