Web Desc
Frontiers of NMR in Molecular Biology VIII
joint with Membrane Proteins: Structure and Mechanism
Organizer(s): James H. Prestegard, Angela M. Gronenborn and Brian D. Sykes
Date: February 04 - 10, 2003
Location: Taos Convention Center (meeting only), Taos, New Mexico, USA
Sponsored in part by The Director's Sponsor Fund
For important information on the coronavirus, please click here
Summary of Meeting:
Nuclear Magnetic Resonance (NMR) has a long history of evolving to meet new challenges of molecular biology; this evolution will be even more rapid in a genomic and post-genomic era. Already the challenge of providing structures of proteins on a genomic scale has produced new NMR approaches to efficient structure determination. The prospect of having more targets for the pharmaceutical industry has spawned new NMR based means of screening for molecular interactions. The realization that biological function often involves the interplay of groups of macromolecules in a dynamic setting has led to new methods for monitoring macromolecular interaction and motion. With new approaches and new realizations come additional challenges. Large volumes of data and new types of data demand innovative approaches to analysis, assemblies of interacting macromolecules means working with ever larger structures, and new sources of data on protein dynamics require new connections to mechanistic models. New technological advances needed to work with larger systems often come from a combination of the solids NMR and solution NMR fields, and computational biology is well poised to organize diverse types of data, generate molecular models, and turn them into predictive tools. The ultimate challenge for the meeting will be to stimulate discussion among scientists representing these diverse fields. The meeting will be largely organized around new approaches to the challenges defined above and provide a forum for discussion among molecular biologists, NMR spectroscopists, computational biologists, and drug design specialists. The program will be organized around problem areas and integrate talks by scientists having different perspectives on their solution. Scheduled breaks between formal presentation sessions are ideal for simulating discussion among participants. Discussion of more practical aspects will be promoted by the addition of afternoon workshops having a tutorial structure.
Discounted Abstract Deadline: October 3 2002
Discounted Registration Deadline: December 4 2002
We gratefully acknowledge additional support for this conference from:

Bruker BioSpin Corp.

Cambridge Isotope Laboratories
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of General Medical Sciences (NIGMS)
Grant No. 1 R13 GM067179-01

National Science Foundation (NSF)
Grant No. MCB-0228138
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, February 04 | 3:00PM - 7:00PM
Registration
Room: Rio Grande Hall D


Tuesday, February 04 | 6:15PM - 7:15PM
Welcome
Room: Rio Grande Hall A-C


Tuesday, February 04 | 7:15PM - 7:30PM
Orientation
Room: Bataan


Tuesday, February 04 | 7:30PM - 8:30PM
Keynote Address (Joint)
Room: Bataan

Speaker 1 of 1
Kurt Wüthrich, ETH Zürich, Switzerland
NMR Techniques for Large Structures in Solution Applied to Membrane Proteins

Wednesday, February 05 | 7:00AM - 8:00AM
Breakfast
Room: Rio Grande Hall A-C


Wednesday, February 05 | 8:00AM - 11:15AM
NMR Studies of Membrane Proteins (Joint)
Room: Bataan

Speaker 1 of 6
Lynmarie K. Thompson, University of Massachusetts, USA
Site-Directed Solid-State NMR Studies of Transmembrane Signaling

Wednesday, February 05 | 8:00AM - 11:15AM
NMR Studies of Membrane Proteins (Joint)
Room: Bataan

Speaker 2 of 6
Timothy A. Cross, Florida State University, USA
Structural Features and Function of the M2 Proton Channel from Influenza A

Wednesday, February 05 | 8:00AM - 11:15AM
NMR Studies of Membrane Proteins (Joint)
Room: Bataan

Speaker 3 of 6
* Charles R. Sanders, Vanderbilt University School of Medicine, USA
A Structural Biophysics Approach to Membrane Protein Misfolding

Wednesday, February 05 | 8:00AM - 11:15AM
NMR Studies of Membrane Proteins (Joint)
Room: Bataan

Speaker 4 of 6
John H. Bushweller, University of Virginia, USA
Solution NMR Approach to the Structures of Integral Membrane Proteins: Outer Membrane Protein A (OmpA) as a Paradigm

Wednesday, February 05 | 8:00AM - 11:15AM
NMR Studies of Membrane Proteins (Joint)
Room: Bataan

Speaker 5 of 6
Jun Qin, Lerner Research Institute, USA
Short Talk: Structural Basis of Integrin-Mediated Signaling in Cell Adhesion

Wednesday, February 05 | 8:00AM - 11:15AM
NMR Studies of Membrane Proteins (Joint)
Room: Bataan

Speaker 6 of 6
Josep Rizo, University of Texas Southwestern Medical Center, USA
Short Talk: Differential Mechanisms of Action of Presynaptic C2-Domains

Wednesday, February 05 | 9:20AM - 9:40AM
Coffee Break
Room: Rio Grande Hall A-C


Wednesday, February 05 | 2:00PM - 3:00PM
Poster Setup
Room: Bataan


Wednesday, February 05 | 3:00PM - 10:00PM
Poster Viewing
Room: Bataan


Wednesday, February 05 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Bataan


Wednesday, February 05 | 5:00PM - 7:00PM
Computational/NMR Interface in Protein Structure Determinati
on

Room: Rio Grande Hall A-B

Speaker 1 of 5
* Carol B. Post, Purdue University, USA

Wednesday, February 05 | 5:00PM - 7:00PM
Computational/NMR Interface in Protein Structure Determinati
on

Room: Rio Grande Hall A-B

Speaker 2 of 5
David A. Case, Rutgers University, USA
What Can We Learn About Hydrogen Bonding from Biomolecular NMR?

Wednesday, February 05 | 5:00PM - 7:00PM
Computational/NMR Interface in Protein Structure Determinati
on

Room: Rio Grande Hall A-B

Speaker 3 of 5
Jeffrey Skolnick, Georgia Institute of Technology, USA
Prediction of Protein Structure and Function on a Genomic Scale

Wednesday, February 05 | 5:00PM - 7:00PM
Computational/NMR Interface in Protein Structure Determinati
on

Room: Rio Grande Hall A-B

Speaker 4 of 5
Michael Nilges, Institut Pasteur, France
Inferential Structure Determination

Wednesday, February 05 | 5:00PM - 7:00PM
Computational/NMR Interface in Protein Structure Determinati
on

Room: Rio Grande Hall A-B

Speaker 5 of 5
Alexandre M.J.J. Bonvin, Utrecht University, Netherlands
Short Talk: HADDOCK: A Protein-Protein Docking Approach Based on Biochemical or Biophysical Information

Wednesday, February 05 | 5:00PM - 7:15PM
Membrane Protein Translocation, Folding and Assembly
This session is from Membrane Proteins
Room: Rio Grande Hall D

Speaker 1 of 5
* Donald M. Engelman, Yale University, USA
Stability and Specificity in Membrane Protein Folding


Wednesday, February 05 | 5:00PM - 7:15PM
Membrane Protein Translocation, Folding and Assembly
This session is from Membrane Proteins
Room: Rio Grande Hall D

Speaker 2 of 5
Linda L. Randall, University of Missouri, USA
Interaction between Protein Chaperones during Export in E. coli


Wednesday, February 05 | 5:00PM - 7:15PM
Membrane Protein Translocation, Folding and Assembly
This session is from Membrane Proteins
Room: Rio Grande Hall D

Speaker 3 of 5
Avram M. Slovic, Columbia University, USA
Short Talk: Computational Methods for the Design of Water-Soluble Membrane Proteins


Wednesday, February 05 | 5:00PM - 7:15PM
Membrane Protein Translocation, Folding and Assembly
This session is from Membrane Proteins
Room: Rio Grande Hall D

Speaker 4 of 5
Diane M. Papazian, University of California, Los Angeles, USA
Conformational States of Voltage Gated Channels


Wednesday, February 05 | 5:00PM - 7:15PM
Membrane Protein Translocation, Folding and Assembly
This session is from Membrane Proteins
Room: Rio Grande Hall D

Speaker 5 of 5
Christine A. Hrycyna, Purdue University, USA
Short Talk: Molecular Mechanisms of Ras Isoprenylcysteine Carboxyl Methyltransferase (ICMT)


Wednesday, February 05 | 7:00PM - 8:00PM
Social Hour
Room: Bataan


Wednesday, February 05 | 8:00PM - 10:00PM
Poster Session 1: Targets and Approaches for Drug Discovery
Room: Bataan


Thursday, February 06 | 7:00AM - 8:00AM
Breakfast
Room: Bataan


Thursday, February 06 | 8:00AM - 11:15AM
Large Proteins and Large Protein Assemblies
Room: Rio Grande Hall A-B

Speaker 1 of 8
* Angela M. Gronenborn, University of Pittsburgh, USA

Thursday, February 06 | 8:00AM - 11:15AM
Large Proteins and Large Protein Assemblies
Room: Rio Grande Hall A-B

Speaker 2 of 8
Gerhard Wagner, Harvard Medical School, USA
Structures and Interactions of Proteins in Eukaryotic Translation Initiation

Thursday, February 06 | 8:00AM - 11:15AM
Large Proteins and Large Protein Assemblies
Room: Rio Grande Hall A-B

Speaker 3 of 8
Jacob Schaefer, Washington University, USA
Cell-Wall Complexes of Vancomycins in Whole Cells of S. aureus

Thursday, February 06 | 8:00AM - 11:15AM
Large Proteins and Large Protein Assemblies
Room: Rio Grande Hall A-B

Speaker 4 of 8
Brian D. Sykes, University of Alberta, Canada
Calcium Regulatory Proteins: From Solution to Intact Muscle Fibers

Thursday, February 06 | 8:00AM - 11:15AM
Large Proteins and Large Protein Assemblies
Room: Rio Grande Hall A-B

Speaker 5 of 8
Lewis E. Kay, University of Toronto, Canada
Domain Orientations in Large Proteins

Thursday, February 06 | 8:00AM - 11:15AM
Large Proteins and Large Protein Assemblies
Room: Rio Grande Hall A-B

Speaker 6 of 8
Richard W. Kriwacki, St. Jude Children's Research Hospital, USA
Solution NMR Studies of Cell Cycle Regulatory Complexes

Thursday, February 06 | 8:00AM - 11:15AM
Large Proteins and Large Protein Assemblies
Room: Rio Grande Hall A-B

Speaker 7 of 8
Tomas Åkerud, AstraZeneca, Sweden
Short Talk: Oligomerisation and Intramolecular Dynamics of Low Molecular Weight Protein Tyrosine Phosphatase Studied by NMR and Hydrodynamic Calculations


Thursday, February 06 | 8:00AM - 11:15AM
Large Proteins and Large Protein Assemblies
Room: Rio Grande Hall A-B

Speaker 8 of 8
Paul B. Card, University of Texas Southwestern Medical Center, USA
Short Talk: PAS Domain Mediated Signaling in the Hypoxia Response

Thursday, February 06 | 8:00AM - 11:00AM
Ion Channels I
This session is from Membrane Proteins
Room: Rio Grande Hall D

Speaker 1 of 6
* Douglas C. Rees, California Institute of Technology, USA


Thursday, February 06 | 8:00AM - 11:00AM
Ion Channels I
This session is from Membrane Proteins
Room: Rio Grande Hall D

Speaker 2 of 6
Randal B. Bass, California Institute of Technology, USA
Crystal Structure of MscS, a Voltage- and Mechano-Gated Channel


Thursday, February 06 | 8:00AM - 11:00AM
Ion Channels I
This session is from Membrane Proteins
Room: Rio Grande Hall D

Speaker 3 of 6
Sergei I. Sukharev, University of Maryland, USA
Mechanistic Studies of the MscL Mechanosensitive Channel


Thursday, February 06 | 8:00AM - 11:00AM
Ion Channels I
This session is from Membrane Proteins
Room: Rio Grande Hall D

Speaker 4 of 6
Eduardo A. Perozo, University of Chicago, USA
Large-Scale Rearrangements in Mechanosensitive Channel Gating


Thursday, February 06 | 8:00AM - 11:00AM
Ion Channels I
This session is from Membrane Proteins
Room: Rio Grande Hall D

Speaker 5 of 6
Merritt Maduke, Stanford University, USA
Probing the Mechanisms of 'ClC' Chloride Channels


Thursday, February 06 | 8:00AM - 11:00AM
Ion Channels I
This session is from Membrane Proteins
Room: Rio Grande Hall D

Speaker 6 of 6
Kenneth H. Lundstrom, BioXtal, Inc., Switzerland
Short Talk: MePNet: Structural Genomics Initiative on Membrane Proteins


Thursday, February 06 | 9:20AM - 9:40AM
Coffee Break
Room: Bataan


Thursday, February 06 | 11:00AM - 1:00PM
Poster Setup
Room: Bataan


Thursday, February 06 | 1:00PM - 10:00PM
Poster Viewing
Room: Bataan


Thursday, February 06 | 2:30PM - 4:30PM
Workshop in Honor of Sunney Chan (Joint)
Room: Rio Grande Hall A-C

Speaker 1 of 6
* Joseph J. Falke, University of Colorado, USA

Thursday, February 06 | 2:30PM - 4:30PM
Workshop in Honor of Sunney Chan (Joint)
Room: Rio Grande Hall A-C

Speaker 2 of 6
* James H. Prestegard, University of Georgia, USA

Thursday, February 06 | 2:30PM - 4:30PM
Workshop in Honor of Sunney Chan (Joint)
Room: Rio Grande Hall A-C

Speaker 3 of 6
Lynmarie K. Thompson, University of Massachusetts, USA

Thursday, February 06 | 2:30PM - 4:30PM
Workshop in Honor of Sunney Chan (Joint)
Room: Rio Grande Hall A-C

Speaker 4 of 6
Gary Brudvig, Yale University, USA
Magnetic Resonance Studies of Transmembrane Electron Transfer

Thursday, February 06 | 2:30PM - 4:30PM
Workshop in Honor of Sunney Chan (Joint)
Room: Rio Grande Hall A-C

Speaker 5 of 6
David F. Blair, University of Utah, USA
Membrane Protein Structures in the Bacterial Rotary Motor

Thursday, February 06 | 2:30PM - 4:30PM
Workshop in Honor of Sunney Chan (Joint)
Room: Rio Grande Hall A-C

Speaker 6 of 6
Hiep-Hoa T. Nguyen, TransMembrane Biosciences, USA
Methods for Overexpression of Membrane Proteins

Thursday, February 06 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Bataan


Thursday, February 06 | 5:00PM - 7:00PM
Structural Genomics - New Experimental Approaches. Session
Sponsored in part by Bruker BioSpin Corporation.

Room: Rio Grande Hall A-B

Speaker 1 of 5
* Gerhard Wagner, Harvard Medical School, USA

Thursday, February 06 | 5:00PM - 7:00PM
Structural Genomics - New Experimental Approaches. Session
Sponsored in part by Bruker BioSpin Corporation.

Room: Rio Grande Hall A-B

Speaker 2 of 5
Gaetano Thomas Montelione, Rutgers University, USA
Protein Sample Production Technologies for Large-Scale Structural Genomics

Thursday, February 06 | 5:00PM - 7:00PM
Structural Genomics - New Experimental Approaches. Session
Sponsored in part by Bruker BioSpin Corporation.

Room: Rio Grande Hall A-B

Speaker 3 of 5
Cheryl Arrowsmith, University of Toronto, Canada
Structural Proteomics: A Tool for Annotation of the Genome

Thursday, February 06 | 5:00PM - 7:00PM
Structural Genomics - New Experimental Approaches. Session
Sponsored in part by Bruker BioSpin Corporation.

Room: Rio Grande Hall A-B

Speaker 4 of 5
James H. Prestegard, University of Georgia, USA
Residual Dipolar Couplings: A Basis for Structure Determination and Classification

Thursday, February 06 | 5:00PM - 7:00PM
Structural Genomics - New Experimental Approaches. Session
Sponsored in part by Bruker BioSpin Corporation.

Room: Rio Grande Hall A-B

Speaker 5 of 5
Wolfgang Peti, University of Arizona, USA
Short Talk: NMR for Structural Genomics: The Thermotoga maritima Proteome

Thursday, February 06 | 5:00PM - 7:15PM
Receptors I
This session is from Membrane Proteins
Room: Rio Grande Hall D

Speaker 1 of 5
Joseph J. Falke, University of Colorado, USA
Receptor Transmembrane Signaling and Kinase Regulation


Thursday, February 06 | 5:00PM - 7:15PM
Receptors I
This session is from Membrane Proteins
Room: Rio Grande Hall D

Speaker 2 of 5
* James A. Wells, University of California, San Francisco, USA
Site-Directed Drug Discovery at Signaling Interfaces


Thursday, February 06 | 5:00PM - 7:15PM
Receptors I
This session is from Membrane Proteins
Room: Rio Grande Hall D

Speaker 3 of 5
K. Christopher Garcia, Stanford University School of Medicine, USA
New Structural Paradigms in Receptor/Ligand Interactions


Thursday, February 06 | 5:00PM - 7:15PM
Receptors I
This session is from Membrane Proteins
Room: Rio Grande Hall D

Speaker 4 of 5
Nagarajan Vaidehi, City of Hope National Medical Center, USA
Short Talk: Structure and Function for G Protein-Coupled Receptors


Thursday, February 06 | 5:00PM - 7:15PM
Receptors I
This session is from Membrane Proteins
Room: Rio Grande Hall D

Speaker 5 of 5
Reinhard Grisshammer, NIH/NINDS, USA
Short Talk: Expression and Purification of G-Protein-Coupled Receptors for Structure Determination


Thursday, February 06 | 7:00PM - 8:00PM
Social Hour
Room: Bataan


Thursday, February 06 | 8:00PM - 10:00PM
Poster Session 2: Nucleic Acids and Their Complexes
Room: Bataan


Friday, February 07 | 7:00AM - 8:00AM
Breakfast
Room: Bataan


Friday, February 07 | 8:00AM - 11:15AM
New Methods in NMR
Room: Rio Grande Hall A-B

Speaker 1 of 7
* Brian D. Sykes, University of Alberta, Canada

Friday, February 07 | 8:00AM - 11:15AM
New Methods in NMR
Room: Rio Grande Hall A-B

Speaker 2 of 7
Stanley J. Opella, University of California, San Diego, USA
New NMR Methods for Membrane Proteins

Friday, February 07 | 8:00AM - 11:15AM
New Methods in NMR
Room: Rio Grande Hall A-B

Speaker 3 of 7
Robert G. Griffin, Massachusetts Institute of Technology, USA
Amyloid and Membrane Protein Structure Determination with Dynamic Nuclear Polarization and MAS Dipolar Recoupling

Friday, February 07 | 8:00AM - 11:15AM
New Methods in NMR
Room: Rio Grande Hall A-B

Speaker 4 of 7
Teresa Carlomagno, Universität Hannover, Germany
Cross-Correlated Relaxation Rates: Measuring Torsion Angles in Carbon Chains of Proteins and Protein-Ligand Complexes

Friday, February 07 | 8:00AM - 11:15AM
New Methods in NMR
Room: Rio Grande Hall A-B

Speaker 5 of 7
Ad Bax, NIDDK, National Institutes of Health, USA
Shortcuts in NMR Structure Determination

Friday, February 07 | 8:00AM - 11:15AM
New Methods in NMR
Room: Rio Grande Hall A-B

Speaker 6 of 7
Alfred Redfield, Brandeis University, USA
Short Talk: Field-Cycling Studies of Diverse Biopolymers by Field Cycling in a Shared Instrument: Screening of Binding?

Friday, February 07 | 8:00AM - 11:15AM
New Methods in NMR
Room: Rio Grande Hall A-B

Speaker 7 of 7
John L. Markley, University of Wisconsin-Madison, USA
Short Talk: Cell-Free Preparation of Proteins for NMR Spectroscopy

Friday, February 07 | 8:00AM - 11:00AM
Transporters I
This session is from Membrane Proteins
Room: Rio Grande Hall D

Speaker 1 of 5
* H. Ronald Kaback, University of California, Los Angeles, USA
Structure and Mechanism of Lac Permease


Friday, February 07 | 8:00AM - 11:00AM
Transporters I
This session is from Membrane Proteins
Room: Rio Grande Hall D

Speaker 2 of 5
Geoffrey Chang, The Scripps Research Institute, USA
Structural Analysis of MDR-ABC Transporter


Friday, February 07 | 8:00AM - 11:00AM
Transporters I
This session is from Membrane Proteins
Room: Rio Grande Hall D

Speaker 3 of 5
Nancy Carrasco, Albert Einstein College of Medicine, USA
The Sodium/Iodide Symporter (NIS): Characterization, Regulation and Medical Significance


Friday, February 07 | 8:00AM - 11:00AM
Transporters I
This session is from Membrane Proteins
Room: Rio Grande Hall D

Speaker 4 of 5
Sunney Ignatius Chan, California Institute of Technology, USA
Structure and Mechanism of Membrane-Bound Electron Transport and Energy Transducing Enzymes: Old Tricks and New Strategies


Friday, February 07 | 8:00AM - 11:00AM
Transporters I
This session is from Membrane Proteins
Room: Rio Grande Hall D

Speaker 5 of 5
Kaspar P. Locher, ETH - Zürich, Switzerland
Short Talk: Crystal Structure of a Bacterial ABC Transporter


Friday, February 07 | 9:20AM - 9:40AM
Coffee Break
Room: Bataan


Friday, February 07 | 11:00AM - 1:00PM
Poster Setup
Room: Bataan


Friday, February 07 | 1:00PM - 10:00PM
Poster Viewing
Room: Bataan


Friday, February 07 | 2:30PM - 4:30PM
Workshop on Partially Aligned Molecules
Room: Rio Grande Hall A-B

Speaker 1 of 9
* Ad Bax, NIDDK, National Institutes of Health, USA

Friday, February 07 | 2:30PM - 4:30PM
Workshop on Partially Aligned Molecules
Room: Rio Grande Hall A-B

Speaker 2 of 9
Gianluigi Veglia, University of Minnesota, USA
Residual Dipolar Couplings for Use in NMR Structure Determination of Membrane Proteins

Friday, February 07 | 2:30PM - 4:30PM
Workshop on Partially Aligned Molecules
Room: Rio Grande Hall A-B

Speaker 3 of 9
Ronaldo M. Mohana-Borges, Federal University of Rio de Janeiro (UFRJ), Brazil
Mapping the Topology of Unfolded and Partially Folded Proteins by Residual Dipolar Couplings

Friday, February 07 | 2:30PM - 4:30PM
Workshop on Partially Aligned Molecules
Room: Rio Grande Hall A-B

Speaker 4 of 9
Markus Zweckstetter, Max-Planck Institute for Biophysical Chemistry / DZNE, Germany
Rapid Characterization of Protein Assemblies using NMR Derived Molecular Alignment

Friday, February 07 | 2:30PM - 4:30PM
Workshop on Partially Aligned Molecules
Room: Rio Grande Hall A-B

Speaker 5 of 9
Yufeng Wei, Seton Hall University, USA
Structure of the Anti-Apoptotic Protein PEA-15 Using Residual Dipolar Coupling Measurements

Friday, February 07 | 2:30PM - 4:30PM
Workshop on Partially Aligned Molecules
Room: Rio Grande Hall A-B

Speaker 6 of 9
Frédéric H.T. Allain, ETH Zurich, Switzerland
Solution Structures of Two RNA Substrates for Editing

Friday, February 07 | 2:30PM - 4:30PM
Workshop on Partially Aligned Molecules
Room: Rio Grande Hall A-B

Speaker 7 of 9
Justin Wu, Ohio State University, USA
Solution Structure of gS-crystallin from Residual Dipolar Couplings

Friday, February 07 | 2:30PM - 4:30PM
Workshop on Partially Aligned Molecules
Room: Rio Grande Hall A-B

Speaker 8 of 9
Tobias Sebastian Ulmer, NIDDK, National Institutes of Health, USA
Refinement of the Backbone Geometry of GB3 Using Dipolar Couplings. Insight into the Proton Positions

Friday, February 07 | 2:30PM - 4:30PM
Workshop on Partially Aligned Molecules
Room: Rio Grande Hall A-B

Speaker 9 of 9
Mirko Hennig, The Scripps Research Institute, USA
Labeling Methodology and 19F NMR of Fluoropyrimidine Substituted RNA

Friday, February 07 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Bataan


Friday, February 07 | 5:00PM - 7:00PM
Protein Modifications and Interactions
Room: Rio Grande Hall A-B

Speaker 1 of 4
* Erik R. P. Zuiderweg, University of Michigan, USA

Friday, February 07 | 5:00PM - 7:00PM
Protein Modifications and Interactions
Room: Rio Grande Hall A-B

Speaker 2 of 4
David E. Wemmer, University of California, Berkeley, USA
Phosphoaspartate Signaling and Enzymology

Friday, February 07 | 5:00PM - 7:00PM
Protein Modifications and Interactions
Room: Rio Grande Hall A-B

Speaker 3 of 4
Angela M. Gronenborn, University of Pittsburgh, USA
A Protein Contortionist: Core Mutations Switch Monomeric Protein GB1 into Different Multimers

Friday, February 07 | 5:00PM - 7:00PM
Protein Modifications and Interactions
Room: Rio Grande Hall A-B

Speaker 4 of 4
David H. Live, University of Georgia, USA
Short Talk: Structure and Dynamics of Mucin Motifs

Friday, February 07 | 5:00PM - 7:15PM
Ion Channels II
This session is from Membrane Proteins
Room: Rio Grande Hall D

Speaker 1 of 4
* Richard W. Aldrich, Stanford University, USA
Conformational Changes and Allosteric Interactions in Potassium Channels Gated by Voltage and Calcium


Friday, February 07 | 5:00PM - 7:15PM
Ion Channels II
This session is from Membrane Proteins
Room: Rio Grande Hall D

Speaker 2 of 4
Youxing Jiang, University of Texas Southwestern Medical Center, USA
Structure and Mechanism of a Calcium-Gated Potassium Channel


Friday, February 07 | 5:00PM - 7:15PM
Ion Channels II
This session is from Membrane Proteins
Room: Rio Grande Hall D

Speaker 3 of 4
Francisco Bezanilla, University of Chicago, USA
Stuctural Rearrangement during Voltage Gating


Friday, February 07 | 5:00PM - 7:15PM
Ion Channels II
This session is from Membrane Proteins
Room: Rio Grande Hall D

Speaker 4 of 4
Michael C. Wiener, University of Virginia, USA
Short Talk: Substrate-Induced Transmembrane Signaling in the Outer-Membrane Cobalamin Transporter BtuB


Friday, February 07 | 7:00PM - 8:00PM
Social Hour
Room: Bataan


Friday, February 07 | 8:00PM - 10:00PM
Poster Session 3: New Protein and Macromolecular Structures
Room: Bataan


Saturday, February 08 | 7:00AM - 8:00AM
Breakfast
Room: Bataan


Saturday, February 08 | 8:00AM - 11:15AM
Small Molecule-Macromolecule Interactions and Drug Design
Room: Rio Grande Hall A-B

Speaker 1 of 7
* David E. Wemmer, University of California, Berkeley, USA

Saturday, February 08 | 8:00AM - 11:15AM
Small Molecule-Macromolecule Interactions and Drug Design
Room: Rio Grande Hall A-B

Speaker 2 of 7
Jonathan M. Moore, Vertex Pharmaceuticals Incorporated, USA
NMR-Based Strategies in Drug Discovery

Saturday, February 08 | 8:00AM - 11:15AM
Small Molecule-Macromolecule Interactions and Drug Design
Room: Rio Grande Hall A-B

Speaker 3 of 7
Bernd Meyer, University of Hamburg, Germany
STD-NMR to Screen Libraries and to Characterize Ligand Binding to Receptors

Saturday, February 08 | 8:00AM - 11:15AM
Small Molecule-Macromolecule Interactions and Drug Design
Room: Rio Grande Hall A-B

Speaker 4 of 7
Wolfgang Jahnke, Novartis Institutes for BioMedical Research, Switzerland
New Methods and Applications of NMR in Drug Discovery

Saturday, February 08 | 8:00AM - 11:15AM
Small Molecule-Macromolecule Interactions and Drug Design
Room: Rio Grande Hall A-B

Speaker 5 of 7
Philip J. Hajduk, Abbott Laboratories, USA
NMR in Drug Discovery and Design

Saturday, February 08 | 8:00AM - 11:15AM
Small Molecule-Macromolecule Interactions and Drug Design
Room: Rio Grande Hall A-B

Speaker 6 of 7
Andrew J. Benie, Novo Nordisk A/S, Denmark
Short Talk: NMR Studies of the Binding of Ligands to a Native Rhinovirus

Saturday, February 08 | 8:00AM - 11:15AM
Small Molecule-Macromolecule Interactions and Drug Design
Room: Rio Grande Hall A-B

Speaker 7 of 7
John P. Marino, National Institute of Standards and Technology, USA
Short Talk: Using 19F NMR to Screen Small Molecules that Target
a Soluble Mimic of the Light-Activated GPCR Rhodopsin




Saturday, February 08 | 8:00AM - 11:00AM
Receptors II
This session is from Membrane Proteins
Room: Rio Grande Hall D

Speaker 1 of 5
* Wayne L. Hubbell, University of California, Los Angeles, USA
Mechanism of Rhodopsin Signaling


Saturday, February 08 | 8:00AM - 11:00AM
Receptors II
This session is from Membrane Proteins
Room: Rio Grande Hall D

Speaker 2 of 5
Brian K. Kobilka, Stanford University School of Medicine, USA
Ligand-Induced Conformational Changes in the Beta2 Adrenoceptor


Saturday, February 08 | 8:00AM - 11:00AM
Receptors II
This session is from Membrane Proteins
Room: Rio Grande Hall D

Speaker 3 of 5
Jonathan A. Javitch, Columbia University, USA
Mapping the Surface of the Binding-Site Crevice of the Dopamine D2 Receptor: Clues to the Structural Bases of Pharmacological Specificity and to the Identification of a Symmetrical Homodimer Interface


Saturday, February 08 | 8:00AM - 11:00AM
Receptors II
This session is from Membrane Proteins
Room: Rio Grande Hall D

Speaker 4 of 5
Mark Yeager, University of Virginia School of Medicine, USA
3D Structure of Membrane Proteins


Saturday, February 08 | 8:00AM - 11:00AM
Receptors II
This session is from Membrane Proteins
Room: Rio Grande Hall D

Speaker 5 of 5
Eric J. Hustedt, Vanderbilt University, USA
Short Talk: New Models and Methods for the Analysis of Dipolar Coupling Between Spin Labels


Saturday, February 08 | 9:20AM - 9:40AM
Coffee Break
Room: Bataan


Saturday, February 08 | 11:00AM - 1:00PM
Poster Setup
Room: Bataan


Saturday, February 08 | 1:00PM - 10:00PM
Poster Viewing
Room: Bataan


Saturday, February 08 | 2:30PM - 4:30PM
Workshop on Automation of Data Analysis
Room: Rio Grande Hall A-B

Speaker 1 of 8
* Michael Nilges, Institut Pasteur, France

Saturday, February 08 | 2:30PM - 4:30PM
Workshop on Automation of Data Analysis
Room: Rio Grande Hall A-B

Speaker 2 of 8
Xiaolian Gao, University of Houston, USA
Chemical Shift Correlated Protein Data Base (CSC-PDB) for Automated Protein Structure Determination

Saturday, February 08 | 2:30PM - 4:30PM
Workshop on Automation of Data Analysis
Room: Rio Grande Hall A-B

Speaker 3 of 8
Thomas Szyperski, SUNY at Buffalo, USA
GFT NMR: New Methodology to Rapidly Obtain Precise High-Dimensional Spectral Information


Saturday, February 08 | 2:30PM - 4:30PM
Workshop on Automation of Data Analysis
Room: Rio Grande Hall A-B

Speaker 4 of 8
Pei Zhou, Duke University Medical Center, USA
A Novel Exhaustive Search Algorithm for the Computer-Assisted Backbone Resonance Assignment from NMR Data

Saturday, February 08 | 2:30PM - 4:30PM
Workshop on Automation of Data Analysis
Room: Rio Grande Hall A-B

Speaker 5 of 8
Sven G. Hyberts, Harvard Medical School, USA
IBIS, a User-Interactive Tool for Automated Sequential Assignment of Protein Spectra from Triple-Resonance Experiments

Saturday, February 08 | 2:30PM - 4:30PM
Workshop on Automation of Data Analysis
Room: Rio Grande Hall A-B

Speaker 6 of 8
Torsten Herrmann, ETH - Zurich, Switzerland
Automated NOESY Peak Picking and NOE Assignment with the New Software RADAR

Saturday, February 08 | 2:30PM - 4:30PM
Workshop on Automation of Data Analysis
Room: Rio Grande Hall A-B

Speaker 7 of 8
Jeffrey C. Hoch, Rowland Institute, USA
Bayesian Restraint Potentials for Consistent Inference of Biomolecular Structure from NMR Data

Saturday, February 08 | 2:30PM - 4:30PM
Workshop on Automation of Data Analysis
Room: Rio Grande Hall A-B

Speaker 8 of 8
Eldon L. Ulrich, University of Wisconsin-Madison, USA
BioMagResBank (BMRB)

Saturday, February 08 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Bataan


Saturday, February 08 | 5:00PM - 7:00PM
Nucleic Acids and Protein-Nucleic Acid Complexes
Room: Rio Grande Hall A-B

Speaker 1 of 5
* Harald Schwalbe, University of Frankfurt, Germany

Saturday, February 08 | 5:00PM - 7:00PM
Nucleic Acids and Protein-Nucleic Acid Complexes
Room: Rio Grande Hall A-B

Speaker 2 of 5
Joseph D. Puglisi, Stanford University, USA
NMR Investigations of Large RNAs

Saturday, February 08 | 5:00PM - 7:00PM
Nucleic Acids and Protein-Nucleic Acid Complexes
Room: Rio Grande Hall A-B

Speaker 3 of 5
Arthur Pardi, University of Colorado, Boulder, USA
Structure, Dynamics and Stability of tRNAs in Solution

Saturday, February 08 | 5:00PM - 7:00PM
Nucleic Acids and Protein-Nucleic Acid Complexes
Room: Rio Grande Hall A-B

Speaker 4 of 5
Juli Feigon, University of California, Los Angeles, USA
Biophysical Studies of Telomerase RNA Structure and Mutations Linked to Disease

Saturday, February 08 | 5:00PM - 7:00PM
Nucleic Acids and Protein-Nucleic Acid Complexes
Room: Rio Grande Hall A-B

Speaker 5 of 5
Robert T. Clubb, University of California, Los Angeles, USA
Short Talk: Reading the Major Groove Through Loop Immobilization: Structure and Dynamics of the ARID-DNA Complex

Saturday, February 08 | 5:00PM - 7:00PM
Transporters II and Interfacial Proteins I
This session is from Membrane Proteins
Room: Rio Grande Hall D

Speaker 1 of 5
David S. Cafiso, University of Virginia, USA
Molecular Mechanism of Outer-Membrane Transport Studied using Site-Directed Spin Labeling


Saturday, February 08 | 5:00PM - 7:00PM
Transporters II and Interfacial Proteins I
This session is from Membrane Proteins
Room: Rio Grande Hall D

Speaker 2 of 5
* Barry Honig, Columbia University / HHMI, USA
Computational Studies of the Interaction of Proteins and Peptides with Membrane Interfaces


Saturday, February 08 | 5:00PM - 7:00PM
Transporters II and Interfacial Proteins I
This session is from Membrane Proteins
Room: Rio Grande Hall D

Speaker 3 of 5
William A. Cramer, Purdue University, USA
Import of Colicin E3 across the Outer Membrane: On the Role of the Coiled-Coil and a Two Receptor Mechanism


Saturday, February 08 | 5:00PM - 7:00PM
Transporters II and Interfacial Proteins I
This session is from Membrane Proteins
Room: Rio Grande Hall D

Speaker 4 of 5
Nathan J. Malmberg, University of Colorado Boulder, USA
and


Saturday, February 08 | 5:00PM - 7:00PM
Transporters II and Interfacial Proteins I
This session is from Membrane Proteins
Room: Rio Grande Hall D

Speaker 5 of 5
Susy C. Kohout, University of Colorado, Boulder, USA
Short Talk: EPR Analysis of Calcium-Activated C2 Domains Defines Membrane Docking and Penetration


Saturday, February 08 | 7:00PM - 8:00PM
Social Hour
Room: Bataan


Saturday, February 08 | 8:00PM - 10:00PM
Poster Session 4: Dynamics Applications / Novel Methods in N
MR and Computation
Room: Bataan


Sunday, February 09 | 7:00AM - 8:00AM
Breakfast
Room: Bataan


Sunday, February 09 | 8:00AM - 11:15AM
Motions in Proteins and Nucleic Acids
Room: Rio Grande Hall A-B

Speaker 1 of 7
* James H. Prestegard, University of Georgia, USA

Sunday, February 09 | 8:00AM - 11:15AM
Motions in Proteins and Nucleic Acids
Room: Rio Grande Hall A-B

Speaker 2 of 7
Erik R. P. Zuiderweg, University of Michigan, USA
A Role of Dynamics in Allosteric Proteins

Sunday, February 09 | 8:00AM - 11:15AM
Motions in Proteins and Nucleic Acids
Room: Rio Grande Hall A-B

Speaker 3 of 7
A. Joshua Wand, University of Pennsylvania, USA
Protein Dynamics and Thermodynamics: A View Emerging from NMR Relaxation

Sunday, February 09 | 8:00AM - 11:15AM
Motions in Proteins and Nucleic Acids
Room: Rio Grande Hall A-B

Speaker 4 of 7
David P. Cistola, Washington University School of Medicine, USA
Functionally Relevant Slow Motions in Proteins

Sunday, February 09 | 8:00AM - 11:15AM
Motions in Proteins and Nucleic Acids
Room: Rio Grande Hall A-B

Speaker 5 of 7
Harald Schwalbe, University of Frankfurt, Germany
Nucleic Acids in Motion

Sunday, February 09 | 8:00AM - 11:15AM
Motions in Proteins and Nucleic Acids
Room: Rio Grande Hall A-B

Speaker 6 of 7
Dorothee Kern, Brandeis University, HHMI, USA
Short Talk: Enzymes in Action in the NMR Tube- Protein Dynamics and Reaction Trajectories in Enzyme Catalysis

Sunday, February 09 | 8:00AM - 11:15AM
Motions in Proteins and Nucleic Acids
Room: Rio Grande Hall A-B

Speaker 7 of 7
Ernesto J. Fuentes, University of Iowa, USA
Short Talk: Dynamic Response of a PDZ Domain Protein to Peptide Binding

Sunday, February 09 | 8:00AM - 11:00AM
Interfacial Proteins II
This session is from Membrane Proteins
Room: Rio Grande Hall D

Speaker 1 of 5
Lawrence S. Shapiro, Columbia University, USA
Cadherins and Cell-Cell Adhesion: Structure-Function Analysis


Sunday, February 09 | 8:00AM - 11:00AM
Interfacial Proteins II
This session is from Membrane Proteins
Room: Rio Grande Hall D

Speaker 2 of 5
* Deborah E. Leckband, University of Illinois at Urbana-Champaign, USA
Novel Mechanisms of Cell Adhesion


Sunday, February 09 | 8:00AM - 11:00AM
Interfacial Proteins II
This session is from Membrane Proteins
Room: Rio Grande Hall D

Speaker 3 of 5
Michael S. Wolfe, Brigham and Women's Hospital, Harvard Medical School, USA
Gamma-Secretase: Portrait of an Intramembrane Protease Complex


Sunday, February 09 | 8:00AM - 11:00AM
Interfacial Proteins II
This session is from Membrane Proteins
Room: Rio Grande Hall D

Speaker 4 of 5
Michael J. Overduin, University of Alberta, Canada
Depth of FYVE Domain Membrane Insertione and DIX Domain's Actin and Vesicular Locallization


Sunday, February 09 | 8:00AM - 11:00AM
Interfacial Proteins II
This session is from Membrane Proteins
Room: Rio Grande Hall D

Speaker 5 of 5
Christian F.W. Becker, Gryphon Therapeutics, USA
Short Talk: Solubilization of Tb_MscL by Covalent Detergent Modification


Sunday, February 09 | 9:00AM - 9:20AM
Coffee Break
Room: Bataan


Sunday, February 09 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Bataan


Sunday, February 09 | 5:00PM - 7:00PM
Computational Analysis of Motions in Proteins
Room: Rio Grande Hall A-B

Speaker 1 of 4
* A. Joshua Wand, University of Pennsylvania, USA

Sunday, February 09 | 5:00PM - 7:00PM
Computational Analysis of Motions in Proteins
Room: Rio Grande Hall A-B

Speaker 2 of 4
Carol B. Post, Purdue University, USA
Dengne Virus Capsid Protein

Sunday, February 09 | 5:00PM - 7:00PM
Computational Analysis of Motions in Proteins
Room: Rio Grande Hall A-B

Speaker 3 of 4
Ronald Levy, Stanford University, USA
Recent Studies of Protein Structure and Motions

Sunday, February 09 | 5:00PM - 7:00PM
Computational Analysis of Motions in Proteins
Room: Rio Grande Hall A-B

Speaker 4 of 4
Lennart Nilsson, Karolinska Institute, Sweden
Short Talk: Protein Dynamics, Correlations and Stability

Sunday, February 09 | 7:00PM - 8:00PM
Social Hour
Room: Bataan


Sunday, February 09 | 8:00PM - 11:00PM
Entertainment
Room: Bataan


Sunday, February 09 | 8:00PM - 11:00PM
Cash Bar
Room: Bataan


Monday, February 10 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.