Past Meeting | Keystone Symposia

This meeting took place in the past. Here is a list of meetings that are related:
Dendritic Cells and the Initiation of Adaptive Immunity (2011J7)
Dendritic Cells (2009Z2)
Intracellular and Intercellular Signaling in Dendritic Cell Function (2007J8)
Dendritic Cells at the Center of Innate and Adaptive Immunity: Eradication of Pathogens and Cancer and Control of Immunopathology (2005B2)

Web Desc
Dendritic Cells: Interfaces with Immunobiology and Medicine joint with Cell Biology of the Immune Response Organizer(s): Ralph M. Steinman, Anne O’Garra and Jacques Banchereau Date: March 03 - 08, 2003 Location: Keystone Resort, Keystone, CO, USA Supported by Keystone Symposia For important information on the coronavirus, please click here Summary of Meeting: Dendritic cells control the immune system from different vantage points. Dendritic cells control the responses of several types of lymphocytes; the transition between innate and adaptive immunity; the quality of the T cell response including Th1 polarization, memory, and even tolerance; and immunology in many clinical settings. This multidisciplinary meeting will develop the following areas: 1) vaccination and immune therapy, including the manipulation of dendritic cell function in vivo; 2) interactions of dendritic cells with microbial pathogens including the many innate functions of dendritic cells; 3) the early response of different types of lymphocytes to dendritic cells, and the organization of this response in vivo; 4) the role of dendritic cells in different forms of peripheral tolerance and the regulation of autoimmunity; 5) the specialized properties of dendritic cells in antigen handling, processing and presentation. As has been the case in prior Keystone symposia on dendritic cells, there will be an equal number of presentations invited speakers and speakers selected from the abstracts. Discounted Abstract Deadline: November 5 2002 Discounted Registration Deadline: January 6 2003 We gratefully acknowledge the generous grant for this conference provided by: National Institute of Allergy and Infectious Diseases (NIAID) Grant No. 1 R13 AI053904-01 We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

Dendritic Cells: Interfaces with Immunobiology and Medicine

joint with Cell Biology of the Immune Response

Organizer(s): Ralph M. Steinman, Anne O’Garra and Jacques Banchereau

Date: March 03 - 08, 2003
Location: Keystone Resort, Keystone, CO, USA

Supported by Keystone Symposia

For important information on the coronavirus, please click here

Summary of Meeting:

Dendritic cells control the immune system from different vantage points. Dendritic cells control the responses of several types of lymphocytes; the transition between innate and adaptive immunity; the quality of the T cell response including Th1 polarization, memory, and even tolerance; and immunology in many clinical settings. This multidisciplinary meeting will develop the following areas: 1) vaccination and immune therapy, including the manipulation of dendritic cell function in vivo; 2) interactions of dendritic cells with microbial pathogens including the many innate functions of dendritic cells; 3) the early response of different types of lymphocytes to dendritic cells, and the organization of this response in vivo; 4) the role of dendritic cells in different forms of peripheral tolerance and the regulation of autoimmunity; 5) the specialized properties of dendritic cells in antigen handling, processing and presentation. As has been the case in prior Keystone symposia on dendritic cells, there will be an equal number of presentations invited speakers and speakers selected from the abstracts.

Discounted Abstract Deadline: November 5 2002

Discounted Registration Deadline: January 6 2003

We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1 R13 AI053904-01

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Monday, March 03 \| 3:00PM - 7:00PM Registration Room: Shavano Peak Foyer
Monday, March 03 \| 6:15PM - 7:15PM Welcome Room: Shavano Peak Foyer
Monday, March 03 \| 7:15PM - 7:30PM Orientation Room: Shavano/Torreys
Tuesday, March 04 \| 7:00AM - 8:00AM Breakfast Room: Crestone/Red Cloud
Tuesday, March 04 \| 8:00AM - 11:00AM Dendritic Cells and the Control of Immunity vs. Tolerance Room: Shavano/Torreys Speaker 1 of 4 Yong-Jun Liu, Sanofi, USA Human Epithelial Cells Trigger Dendritic Cell-Mediated Allergic Inflammation by Producing TSLP
Tuesday, March 04 \| 8:00AM - 11:00AM Dendritic Cells and the Control of Immunity vs. Tolerance Room: Shavano/Torreys Speaker 2 of 4 Kayo Inaba, Kyoto University, Japan Peripheral Tolerance via DCs in vivo
Tuesday, March 04 \| 8:00AM - 11:00AM Dendritic Cells and the Control of Immunity vs. Tolerance Room: Shavano/Torreys Speaker 3 of 4 Maria Grazia Roncarolo, Stanford University School of Medicine, USA Role of Regulatory T Cells in Immunological Tolerance
Tuesday, March 04 \| 8:00AM - 11:00AM Dendritic Cells and the Control of Immunity vs. Tolerance Room: Shavano/Torreys Speaker 4 of 4 * Anne O'Garra, Francis Crick Institute, UK Flexibility of Mouse Classical and Plasmacytoid-Derived Dendritic Cells in Directing Th1 and Th2 Cell Development: Dependency on Antigen Dose and Differential Toll-Like Receptor Ligation
Tuesday, March 04 \| 9:20AM - 9:40AM Coffee Break Room: Longs Peak Foyer
Tuesday, March 04 \| 11:00AM - 1:00PM Poster Setup Room: Longs Peak/Grays Peak
Tuesday, March 04 \| 1:00PM - 10:00PM Poster Viewing Room: Longs Peak/Grays Peak
Tuesday, March 04 \| 2:00PM - 4:30PM Workshop 1: Immunity and Tolerance to Tumors Room: Shavano/Torreys Speaker 1 of 10 * Olivera J. Finn, University of Pittsburgh School of Medicine, USA
Tuesday, March 04 \| 2:00PM - 4:30PM Workshop 1: Immunity and Tolerance to Tumors Room: Shavano/Torreys Speaker 2 of 10 Shu-Hsia Chen, Mount Sinai School of Medicine, USA Regulation of Dendritic Cell Function by NK Cells: Mechanisms Underlying the Synergism between IL-12 and 4-1 BB Activation
Tuesday, March 04 \| 2:00PM - 4:30PM Workshop 1: Immunity and Tolerance to Tumors Room: Shavano/Torreys Speaker 3 of 10 Michael D. Gunn, Duke University Medical Center, USA Splenic Immature PDC Induce the Development of IL-10 Producing CD4+ T Regulatory Cells
Tuesday, March 04 \| 2:00PM - 4:30PM Workshop 1: Immunity and Tolerance to Tumors Room: Shavano/Torreys Speaker 4 of 10 Michael R. Shurin, University of Pittsburgh, USA Small Rho GTPases Regulate Dendropoiesis in Cancer
Tuesday, March 04 \| 2:00PM - 4:30PM Workshop 1: Immunity and Tolerance to Tumors Room: Shavano/Torreys Speaker 5 of 10 Sally Ann Litherland, Florida Hospital Cancer Institute, USA STAT5 Dysfunction in Autoimmune Myeloid Antigen Presenting Cell Activation and Differentiation
Tuesday, March 04 \| 2:00PM - 4:30PM Workshop 1: Immunity and Tolerance to Tumors Room: Shavano/Torreys Speaker 6 of 10 Mariolina Salio, Weatherall Institute of Molecular Medicine, UK Efficacy of Murine Myeloid and Plasmacytoid Dendritic Cells in Eliciting Adaptive Immune Responses
Tuesday, March 04 \| 2:00PM - 4:30PM Workshop 1: Immunity and Tolerance to Tumors Room: Shavano/Torreys Speaker 7 of 10 Heather Zwickey, National College of Naturopathic Medicine, USA DCs Presenting Self Antigens: Tolerance or Activation?
Tuesday, March 04 \| 2:00PM - 4:30PM Workshop 1: Immunity and Tolerance to Tumors Room: Shavano/Torreys Speaker 8 of 10 Mohamad Mohty, CHU de Nantes/INSERM U892, France Interferon-Alpha Skews Monocyte Differentiation into Toll-like Receptor 7 Expressing Dendritic Cells with Potent Functional Activities
Tuesday, March 04 \| 2:00PM - 4:30PM Workshop 1: Immunity and Tolerance to Tumors Room: Shavano/Torreys Speaker 9 of 10 Hubert Eng, Virexx Inc., Canada Complexation with Murine MAb-B43.13 Alters the Endocytic Trafficking of the Mucinous Tumor Antigen CA125 after Uptake by Human Dendritic Cells
Tuesday, March 04 \| 2:00PM - 4:30PM Workshop 1: Immunity and Tolerance to Tumors Room: Shavano/Torreys Speaker 10 of 10 Alexandra M. Livingstone, University of Rochester Medical Center, USA Helper-Dependent CD8+ T Cell Memory Requires CD40 Expression on the Immunizing Dendritic Cell, but Not on CD4+ or CD8+ T Cells.
Tuesday, March 04 \| 4:30PM - 5:00PM Coffee & Snacks Available Room: Longs Peak Foyer
Tuesday, March 04 \| 5:00PM - 7:00PM Dendritic Cell Maturation in vivo Room: Shavano/Torreys Speaker 1 of 4 * Anne O'Garra, Francis Crick Institute, UK
Tuesday, March 04 \| 5:00PM - 7:00PM Dendritic Cell Maturation in vivo Room: Shavano/Torreys Speaker 2 of 4 David F. Tough, Edward Jenner Institute for Vaccine Research, UK Regulation of Immune Responses by Type I Interferon
Tuesday, March 04 \| 5:00PM - 7:00PM Dendritic Cell Maturation in vivo Room: Shavano/Torreys Speaker 3 of 4 A. Karolina Palucka, The Jackson Laboratory for Genomic Medicine, USA Dendritic Cells as Melanoma Vaccines
Tuesday, March 04 \| 5:00PM - 7:00PM Dendritic Cell Maturation in vivo Room: Shavano/Torreys Speaker 4 of 4 Masaru Taniguchi, RIKEN RCAI, Japan Regulatory Interaction between Valpha14 NKT Cells and Dendritic Cells
Tuesday, March 04 \| 7:00PM - 8:00PM Social Hour Room: Longs Peak/Grays Peak
Tuesday, March 04 \| 8:00PM - 10:00PM Poster Session 1: DCs in Immunity and Tolerance Room: Longs Peak/Grays Peak
Wednesday, March 05 \| 7:00AM - 8:00AM Breakfast Room: Crestone/Red Cloud
Wednesday, March 05 \| 8:00AM - 11:00AM Antigen Capture by DC in situ Room: Shavano/Torreys Speaker 1 of 5 * Jacques F. Banchereau, The Jackson Laboratory for Genomic Medicine, USA
Wednesday, March 05 \| 8:00AM - 11:00AM Antigen Capture by DC in situ Room: Shavano/Torreys Speaker 2 of 5 Michel C. Nussenzweig, HHMI/Rockefeller University, USA Targeting Antigens to Lymphoid Tissue DCs
Wednesday, March 05 \| 8:00AM - 11:00AM Antigen Capture by DC in situ Room: Shavano/Torreys Speaker 3 of 5 Marc K. Jenkins, University of Minnesota Medical School, USA In Vivo Analysis of Antigen-Presentation to CD4 T Cells
Wednesday, March 05 \| 8:00AM - 11:00AM Antigen Capture by DC in situ Room: Shavano/Torreys Speaker 4 of 5 Giorgio Trinchieri, NCI, National Institutes of Health, USA Physiology of Mouse Interferon Producing Cells
Wednesday, March 05 \| 8:00AM - 11:00AM Antigen Capture by DC in situ Room: Shavano/Torreys Speaker 5 of 5 Akiko Iwasaki, HHMI/Yale University School of Medicine, USA Short Talk: Primary Role of Vaginal Dendritic Cells in Th1 Induction during Genital Herpes Simplex Virus-2 Infection
Wednesday, March 05 \| 9:20AM - 9:40AM Coffee Break Room: Longs Peak Foyer
Wednesday, March 05 \| 11:00AM - 1:00PM Poster Setup Room: Longs Peak/Grays Peak
Wednesday, March 05 \| 1:00PM - 10:00PM Poster Viewing Room: Longs Peak/Grays Peak
Wednesday, March 05 \| 2:00PM - 4:30PM Workshop 2: DC Capture of Antigens and Pathogens Room: Shavano/Torreys Speaker 1 of 12 * Alan Sher, NIAID, National Institutes of Health, USA
Wednesday, March 05 \| 2:00PM - 4:30PM Workshop 2: DC Capture of Antigens and Pathogens Room: Shavano/Torreys Speaker 2 of 12 * Paola Ricciardi-Castagnoli, Toscana Life Science Foundation, Italy
Wednesday, March 05 \| 2:00PM - 4:30PM Workshop 2: DC Capture of Antigens and Pathogens Room: Shavano/Torreys Speaker 3 of 12 Li-Yun Coty Huang, U.S. Food and Drug Administration, USA Brucella abortus Activates Dendritic Cells and Splenocytes to Secrete IL-12p40 and TNFalpha via Different Toll-Like Receptors
Wednesday, March 05 \| 2:00PM - 4:30PM Workshop 2: DC Capture of Antigens and Pathogens Room: Shavano/Torreys Speaker 4 of 12 Marina N. Fleeton, National Institutes of Health, USA CD11blo/CD8alpha- Peyer’s Patch Dendritic Cells Process Epithelial Cell-Associated Viral Antigens following Infection with Reovirus, Type 1 Lang
Wednesday, March 05 \| 2:00PM - 4:30PM Workshop 2: DC Capture of Antigens and Pathogens Room: Shavano/Torreys Speaker 5 of 12 Amy C. Herring, University of Michigan, USA The Role of Pulmonary Dendritic Cells in the Developing T1 Response to Cryptococcus neoformans Infection
Wednesday, March 05 \| 2:00PM - 4:30PM Workshop 2: DC Capture of Antigens and Pathogens Room: Shavano/Torreys Speaker 6 of 12 W. L. William Chang, University of California, Davis, USA Alteration of Dendritic Cell Maturation and Functions by Cytomegalovirus-Encoded Interleukin-10
Wednesday, March 05 \| 2:00PM - 4:30PM Workshop 2: DC Capture of Antigens and Pathogens Room: Shavano/Torreys Speaker 7 of 12 Christopher M. Smith, Walter and Eliza Hall Institute of Medical Research, Australia Conventional CD8a+ Dendritic Cells Prime CTL Immunity to Cutaneous Herpes Simplex Virus-1 Infection
Wednesday, March 05 \| 2:00PM - 4:30PM Workshop 2: DC Capture of Antigens and Pathogens Room: Shavano/Torreys Speaker 8 of 12 Gabriele Pollara, University College London, UK Dendritic Cell Innate Responses to HSV Infection
Wednesday, March 05 \| 2:00PM - 4:30PM Workshop 2: DC Capture of Antigens and Pathogens Room: Shavano/Torreys Speaker 9 of 12 Kevin L. Legge, University of Iowa Carver College of Medicine, USA Respiratory Dendritic Cell Trafficking to the Regional Lymph Nodes is Limited to the Early Stage of Experimental Influenza Infection
Wednesday, March 05 \| 2:00PM - 4:30PM Workshop 2: DC Capture of Antigens and Pathogens Room: Shavano/Torreys Speaker 10 of 12 Maria Rescigno, Humanitas University, Italy Bacteria Impede the Migratory Clearance and the Differentiation of Monocytes into Dendritic Cells to Lymph Nodes and Thereby Limit the Development of Adaptive Immune Responses
Wednesday, March 05 \| 2:00PM - 4:30PM Workshop 2: DC Capture of Antigens and Pathogens Room: Shavano/Torreys Speaker 11 of 12 Leopoldo Flores-Romo, El Centro de Investigación y de Estudios Avanzados del IPN, Mexico Cutaneous Langerhans Dendritic Cells in a Murine Model of Leprosy: in vivo Analysis
Wednesday, March 05 \| 2:00PM - 4:30PM Workshop 2: DC Capture of Antigens and Pathogens Room: Shavano/Torreys Speaker 12 of 12 Anne Hosmalin, Institut Cochin, Inserm U1016, Université Paris Descartes, France Processing of an HIV-1 Immunodominant Restricted Epitope by the Cytosolic Protease TPPII
Wednesday, March 05 \| 4:30PM - 5:00PM Coffee & Snacks Available Room: Longs Peak Foyer
Wednesday, March 05 \| 5:00PM - 7:00PM Exogenous Pathway and Cross-Presentation Room: Shavano/Torreys Speaker 1 of 9 * Jacques F. Banchereau, The Jackson Laboratory for Genomic Medicine, USA
Wednesday, March 05 \| 5:00PM - 7:00PM Exogenous Pathway and Cross-Presentation Room: Shavano/Torreys Speaker 2 of 9 Michael J. Bevan, HHMI/University of Washington, USA Maintaining memory
Wednesday, March 05 \| 5:00PM - 7:00PM Exogenous Pathway and Cross-Presentation Room: Shavano/Torreys Speaker 3 of 9 Sebastian Amigorena, Institut Curie, France Exogenous Pathway via Fc Receptors
Wednesday, March 05 \| 5:00PM - 7:00PM Exogenous Pathway and Cross-Presentation Room: Shavano/Torreys Speaker 4 of 9 Philippe D. Pierre, Centre d'Immunologie Marseille-Luminy, CIML, France Aggregation in Maturing DCs, A Mean to Segregate Self Antigens from the Proteasome
Wednesday, March 05 \| 5:00PM - 7:00PM Exogenous Pathway and Cross-Presentation Room: Shavano/Torreys Speaker 5 of 9 Carl G. Figdor, Radboud University Medical Center, Netherlands Short Talk: The C-Type Lectin DC-SIGN (CD209) is an Antigen Uptake Receptor for Candida albicans on Dendritic Cells
Wednesday, March 05 \| 5:00PM - 7:00PM Exogenous Pathway and Cross-Presentation Room: Shavano/Torreys Speaker 6 of 9 Stefan Freigang, University Hospital Zurich, Switzerland Short Talk: Endogenous Neosynthesis Versus Cross-Presentation of Polioviral Antigen for CTL Priming
Wednesday, March 05 \| 5:00PM - 7:00PM Exogenous Pathway and Cross-Presentation Room: Shavano/Torreys Speaker 7 of 9 Maria Carmen Ramirez Mazcunyan, Fox Chase Cancer Center, USA Short Talk: Macrophages and Dendritic Cells Use the Cytosolic Pathway to Rapidly Cross-Present Antigen from Live, Vaccinia-Infected Cells
Wednesday, March 05 \| 5:00PM - 7:00PM Exogenous Pathway and Cross-Presentation Room: Shavano/Torreys Speaker 8 of 9 Nicolas Glaichenhaus, Centre National de la Recherche Scientifique, France Short Talk: CD11b+ Dendritic Cells are Responsible for the Activation of CD4+ T Cells in Mice Infected with the Intracellular Parasite Leishmania Major
Wednesday, March 05 \| 5:00PM - 7:00PM Exogenous Pathway and Cross-Presentation Room: Shavano/Torreys Speaker 9 of 9 Lélia Delamarre, Genentech, Inc., USA Short Talk: Presentation of Exogenous Antigens on MHC I and MHC II is Differentially Regulated during Dendritic Cell Maturation
Wednesday, March 05 \| 7:00PM - 8:00PM Social Hour Room: Longs Peak/Grays Peak
Wednesday, March 05 \| 8:00PM - 10:00PM Poster Session 2: DC Subsets, Maturation and Immune Response s in vivo Room: Longs Peak/Grays Peak
Thursday, March 06 \| 7:00AM - 8:00AM Breakfast Room: Crestone/Red Cloud
Thursday, March 06 \| 8:00AM - 11:00AM Transmission of Signals to the Nucleus: General Principles ( Joint) Room: Shavano/Torreys Speaker 1 of 6 Joseph Schlessinger, Yale University School of Medicine, USA Tyrosine Kinases
Thursday, March 06 \| 8:00AM - 11:00AM Transmission of Signals to the Nucleus: General Principles ( Joint) Room: Shavano/Torreys Speaker 2 of 6 Amer A. Beg, Moffitt Cancer Center, USA NF-kappaB Signaling in Dendritic Cells
Thursday, March 06 \| 8:00AM - 11:00AM Transmission of Signals to the Nucleus: General Principles ( Joint) Room: Shavano/Torreys Speaker 3 of 6 * Richard A. Flavell, HHMI/Yale University School of Medicine, USA Signal-Mediated Control of Transcription
Thursday, March 06 \| 8:00AM - 11:00AM Transmission of Signals to the Nucleus: General Principles ( Joint) Room: Shavano/Torreys Speaker 4 of 6 Gioacchino Natoli, Humanitas University, Italy Close-Ups of NF-kappaB Recruitment to Target Genes in DCs
Thursday, March 06 \| 8:00AM - 11:00AM Transmission of Signals to the Nucleus: General Principles ( Joint) Room: Shavano/Torreys Speaker 5 of 6 Takashi Kobayashi, University of Pennsylvania, USA Short Talk: TRAF6 Regulates Dendritic Cell Development and Function
Thursday, March 06 \| 8:00AM - 11:00AM Transmission of Signals to the Nucleus: General Principles ( Joint) Room: Shavano/Torreys Speaker 6 of 6 Salome Landmann, Centre Medical Universitaire, Switzerland Short Talk: The Role of the Class II Transactivator (CIITA) in Dendritic Cells
Thursday, March 06 \| 9:20AM - 9:40AM Coffee Break Room: Longs Peak Foyer
Thursday, March 06 \| 11:00AM - 1:00PM Poster Setup Room: Longs Peak/Grays Peak
Thursday, March 06 \| 1:00PM - 10:00PM Poster Viewing Room: Longs Peak/Grays Peak
Thursday, March 06 \| 2:00PM - 4:30PM Workshop 3: Rafts: Fact or Fiction? (Joint) Room: Shavano/Torreys Speaker 1 of 8 * † Derek Toomre, Yale University School of Medicine, USA
Thursday, March 06 \| 2:00PM - 4:30PM Workshop 3: Rafts: Fact or Fiction? (Joint) Room: Shavano/Torreys Speaker 2 of 8 Christian O. Meyer zum Buschenfelde, Yale University, USA Recruitment of CD28 and CD86 to Lipid Rafts during DC-T Cell Interaction Results in Efficient T Cell Priming
Thursday, March 06 \| 2:00PM - 4:30PM Workshop 3: Rafts: Fact or Fiction? (Joint) Room: Shavano/Torreys Speaker 3 of 8 Jeoung-Sook Shin, University of California, San Francisco, USA Mast Cell Endo/Exocytosis Of Particulate Allergens
Thursday, March 06 \| 2:00PM - 4:30PM Workshop 3: Rafts: Fact or Fiction? (Joint) Room: Shavano/Torreys Speaker 4 of 8 Neil Poloso, Allergan Inc., USA Kinetics of MHC Class II Complex Association with Lipid Rafts
Thursday, March 06 \| 2:00PM - 4:30PM Workshop 3: Rafts: Fact or Fiction? (Joint) Room: Shavano/Torreys Speaker 5 of 8 Lee Leserman, Centre d'Immunologie de Marseille-Luminy, France MHC Class II/Peptide Complexes in Lipid Microdomains at the Dendritic Cell Surface Initiate the TH1 CD4 T Cell Phenotype
Thursday, March 06 \| 2:00PM - 4:30PM Workshop 3: Rafts: Fact or Fiction? (Joint) Room: Shavano/Torreys Speaker 6 of 8 Richard M. Siegel, NIAMS, National Institutes of Health, USA Life and Death Decisions in TLR and TNF Family Receptor Signaling
Thursday, March 06 \| 2:00PM - 4:30PM Workshop 3: Rafts: Fact or Fiction? (Joint) Room: Shavano/Torreys Speaker 7 of 8 Alessandra Cambi, Max Planck Institute for Biophysical Chemistry, Germany Distribution of LFA-1 and DC-SIGN in Microdomains on DC by High Resolution Microscopy: Consequences for Cell-Adhesion and Ligand Binding
Thursday, March 06 \| 2:00PM - 4:30PM Workshop 3: Rafts: Fact or Fiction? (Joint) Room: Shavano/Torreys Speaker 8 of 8 Juli J. Unternaehrer, Children's Hospital Boston, USA Surface MHC-II I-E Associates with I-A in Dendritic Cells but Not in B Cells
Thursday, March 06 \| 4:30PM - 5:00PM Coffee & Snacks Available Room: Longs Peak Foyer
Thursday, March 06 \| 5:00PM - 7:00PM Signal Transduction and Antigen Presentation (Joint) Room: Shavano/Torreys Speaker 1 of 5 * Richard A. Flavell, HHMI/Yale University School of Medicine, USA
Thursday, March 06 \| 5:00PM - 7:00PM Signal Transduction and Antigen Presentation (Joint) Room: Shavano/Torreys Speaker 2 of 5 Tsuneyasu Kaisho, RIKEN Research Center for Allergy and Immunology, Japan Pleiotropic Function of Toll-Like Receptors on Dendritic Cells
Thursday, March 06 \| 5:00PM - 7:00PM Signal Transduction and Antigen Presentation (Joint) Room: Shavano/Torreys Speaker 3 of 5 Alan Aderem, Center for Infectious Disease Research, USA Macrophage Phagocytosis: from Genes to Function
Thursday, March 06 \| 5:00PM - 7:00PM Signal Transduction and Antigen Presentation (Joint) Room: Shavano/Torreys Speaker 4 of 5 Ruslan Medzhitov, HHMI/Yale University School of Medicine, USA Toll Pathway of Host Defense
Thursday, March 06 \| 5:00PM - 7:00PM Signal Transduction and Antigen Presentation (Joint) Room: Shavano/Torreys Speaker 5 of 5 Caetano Reis e Sousa, Francis Crick Institute, UK Short Talk: Non-Plasmacytoid Dendritic Cells Act as Interferon-Producing Cells in Response to Cytosolic Double-Stranded RNA
Thursday, March 06 \| 7:00PM - 8:00PM Social Hour Room: Longs Peak/Grays Peak
Thursday, March 06 \| 8:00PM - 10:00PM Poster Session 3: Signal Transduction Room: Longs Peak/Grays Peak
Friday, March 07 \| 7:00AM - 8:00AM Breakfast Room: Crestone/Red Cloud
Friday, March 07 \| 8:00AM - 11:00AM Endocytosis and Lysosomal Transport (Joint) Room: Shavano/Torreys Speaker 1 of 7 * Ira Mellman, Genentech, Inc., USA
Friday, March 07 \| 8:00AM - 11:00AM Endocytosis and Lysosomal Transport (Joint) Room: Shavano/Torreys Speaker 2 of 7 Scott D. Emr, Cornell University, USA Receptor Down-Regulation and Protein Sorting at the Multivesicular Body
Friday, March 07 \| 8:00AM - 11:00AM Endocytosis and Lysosomal Transport (Joint) Room: Shavano/Torreys Speaker 3 of 7 Margaret S. Robinson, University of Cambridge, UK Coat Proteins and Sorting
Friday, March 07 \| 8:00AM - 11:00AM Endocytosis and Lysosomal Transport (Joint) Room: Shavano/Torreys Speaker 4 of 7 Suzanne R. Pfeffer, Stanford University, USA Rab GTPases in Receptor Trafficking
Friday, March 07 \| 8:00AM - 11:00AM Endocytosis and Lysosomal Transport (Joint) Room: Shavano/Torreys Speaker 5 of 7 Giorgio Scita, IFOM Foundation at Campus IFOM-IEO, Italy Integration of Signals Leading to Actin Remodeling and Endocytosis
Friday, March 07 \| 8:00AM - 11:00AM Endocytosis and Lysosomal Transport (Joint) Room: Shavano/Torreys Speaker 6 of 7 Angela Stoddart, University of California, San Francisco, USA Short Talk: Deciphering the Roles of Lipid Rafts and Clathrin in BCR Internalization
Friday, March 07 \| 8:00AM - 11:00AM Endocytosis and Lysosomal Transport (Joint) Room: Shavano/Torreys Speaker 7 of 7 Haoran Zhao, Genentech, USA Short Talk: TRAC-1, A Novel Lymphocyte-Specific E3 Ubiquitin Ligase, Regulates T Cell Activation Downstream of TCR Engagement
Friday, March 07 \| 9:20AM - 9:40AM Coffee Break Room: Longs Peak Foyer
Friday, March 07 \| 4:30PM - 5:00PM Coffee & Snacks Available Room: Longs Peak Foyer
Friday, March 07 \| 5:00PM - 7:00PM Mechanisms of Proteolysis in the Cytosol (Joint) Room: Shavano/Torreys Speaker 1 of 4 * Ira Mellman, Genentech, Inc., USA
Friday, March 07 \| 5:00PM - 7:00PM Mechanisms of Proteolysis in the Cytosol (Joint) Room: Shavano/Torreys Speaker 2 of 4 Wolfgang P. Baumeister, Max Planck Institute of Biochemistry, Germany Electron Tomography: Visualizing Macromolecular Complexes in Intact Cells
Friday, March 07 \| 5:00PM - 7:00PM Mechanisms of Proteolysis in the Cytosol (Joint) Room: Shavano/Torreys Speaker 3 of 4 Jack R. Bennink, NIAID, National Institutes of Health, USA The Origin of Antigenic Peptides and Proteasomal Degradation of Newly Synthesized Proteins
Friday, March 07 \| 5:00PM - 7:00PM Mechanisms of Proteolysis in the Cytosol (Joint) Room: Shavano/Torreys Speaker 4 of 4 Alfred L. Goldberg, Harvard Medical School, USA Peptidases that Function after the Proteasome and Regulate Antigen Presentation
Friday, March 07 \| 7:00PM - 8:00PM Social Hour Room: Longs Peak/Grays Peak
Friday, March 07 \| 8:00PM - 11:00PM Entertainment Room: Longs Peak/Grays Peak
Saturday, March 08 \| 8:00AM - 11:00AM Functional Specializations of the Endocytic Pathway This session is from Immune Response Room: Shavano Speaker 1 of 7 * Ralph M. Steinman, Rockefeller University, USA
Saturday, March 08 \| 8:00AM - 11:00AM Functional Specializations of the Endocytic Pathway This session is from Immune Response Room: Shavano Speaker 2 of 7 Christopher V. Nicchitta, Duke University School of Medicine, USA Heat Shock Proteins and Antigen Presentation
Saturday, March 08 \| 8:00AM - 11:00AM Functional Specializations of the Endocytic Pathway This session is from Immune Response Room: Shavano Speaker 3 of 7 Sergio Grinstein, Hospital for Sick Children, Canada Role of Phosphoinositides in Phagosome Formation and in Bacterial Invasion
Saturday, March 08 \| 8:00AM - 11:00AM Functional Specializations of the Endocytic Pathway This session is from Immune Response Room: Shavano Speaker 4 of 7 Dorothee Schmid, Rockefeller University, USA Short Talk: A Novel Pathway for Endogenous MHC Class II Presentation of a Nuclear Viral Antigen that Involves Autophagy
Saturday, March 08 \| 8:00AM - 11:00AM Functional Specializations of the Endocytic Pathway This session is from Immune Response Room: Shavano Speaker 5 of 7 Dan R. Littman, HHMI/New York University School of Medicine, USA DC-SIGN and Transmission of HIV-1 Following Endocytosis
Saturday, March 08 \| 8:00AM - 11:00AM Functional Specializations of the Endocytic Pathway This session is from Immune Response Room: Shavano Speaker 6 of 7 Eduardo Sergio Trombetta, Yale University, USA Regulation of Lysosomal Function in Dendritic Cells
Saturday, March 08 \| 8:00AM - 11:00AM Functional Specializations of the Endocytic Pathway This session is from Immune Response Room: Shavano Speaker 7 of 7 Thomas J. Hope, Northwestern University, USA Short Talk: Enhancement of HIV Infection by Dendritic Cells: Transfer of HIV to Target Cells Through an Infectious Synapse
Saturday, March 08 \| 10:21AM - 10:21AM Departure *Session Chair †Invited, not yet responded.
Saturday, March 08 \| 2:00PM - 4:30PM Workshop 4: Mechanisms of Antigen Processing and Presentatio n This session is from Immune Response Room: Shavano Speaker 1 of 12 * Hans-Georg Rammensee, University of Tübingen, Germany
Saturday, March 08 \| 2:00PM - 4:30PM Workshop 4: Mechanisms of Antigen Processing and Presentatio n This session is from Immune Response Room: Shavano Speaker 2 of 12 * Ira Mellman, Genentech, Inc., USA
Saturday, March 08 \| 2:00PM - 4:30PM Workshop 4: Mechanisms of Antigen Processing and Presentatio n This session is from Immune Response Room: Shavano Speaker 3 of 12 Deborah Palliser, Takeda, USA Delineation of the Pathway Taken by a Heat Shock Fusion Protein to Gain Access to the MHC Class I Processing Pathway in Dendritic Cells
Saturday, March 08 \| 2:00PM - 4:30PM Workshop 4: Mechanisms of Antigen Processing and Presentatio n This session is from Immune Response Room: Shavano Speaker 4 of 12 Dorian B. McGavern, NINDS, National Institutes of Health, USA Visualizing Antigen-Specific T Cells Involved in Immunopathogenesis
Saturday, March 08 \| 2:00PM - 4:30PM Workshop 4: Mechanisms of Antigen Processing and Presentatio n This session is from Immune Response Room: Shavano Speaker 5 of 12 Scott A. Wetzel, University of Montana, USA Peptide Specific Transfer of MHC From APC to T cells Through the Immunological Synapse
Saturday, March 08 \| 2:00PM - 4:30PM Workshop 4: Mechanisms of Antigen Processing and Presentatio n This session is from Immune Response Room: Shavano Speaker 6 of 12 Heiichiro Udono, Nagasaki University, Japan Two Distinct Pathways Mediated by PA28 and hsp90 in Antigen Processing that is Linked with MHC I Polymorphism
Saturday, March 08 \| 2:00PM - 4:30PM Workshop 4: Mechanisms of Antigen Processing and Presentatio n This session is from Immune Response Room: Shavano Speaker 7 of 12 Michael F. Princiotta, Advaxis, Inc, USA Quantitating Viral Protein Synthesis, Degradation and Endogenous Antigen Processing
Saturday, March 08 \| 2:00PM - 4:30PM Workshop 4: Mechanisms of Antigen Processing and Presentatio n This session is from Immune Response Room: Shavano Speaker 8 of 12 Ona E. Bloom, Yale University School of Medicine, USA Spinophilin, a Neuronal Protein at the Immunological Synapse
Saturday, March 08 \| 2:00PM - 4:30PM Workshop 4: Mechanisms of Antigen Processing and Presentatio n This session is from Immune Response Room: Shavano Speaker 9 of 12 Julie Magarian Blander, Weill Cornell Medicine, Cornell University, USA Signals from Toll-Like Receptors Control Phagolysosomal Fusion
Saturday, March 08 \| 2:00PM - 4:30PM Workshop 4: Mechanisms of Antigen Processing and Presentatio n This session is from Immune Response Room: Shavano Speaker 10 of 12 Babak Javid, Tsinghua University School of Medicine, China Efficient Cross-Presentation of Mycobacterial Heat Shock Protein / Antigen Complexes by Human Dendritic Cells
Saturday, March 08 \| 2:00PM - 4:30PM Workshop 4: Mechanisms of Antigen Processing and Presentatio n This session is from Immune Response Room: Shavano Speaker 11 of 12 Wilfred A. Jefferies, University of British Columbia, Canada The Cytoplasmic Domain of MHC Class I Proteins Controls Intracellular Trafficking and Cross-Presentation
Saturday, March 08 \| 2:00PM - 4:30PM Workshop 4: Mechanisms of Antigen Processing and Presentatio n This session is from Immune Response Room: Shavano Speaker 12 of 12 Marco A. Purbhoo, Howard Hughes Medical Institute, USA Differential Dynamics of CD8, TCR, and MHC at the Immunological Synapse
Saturday, March 08 \| 5:00PM - 7:00PM Cell Migration This session is from Immune Response Room: Shavano Speaker 1 of 5 * Ralph M. Steinman, Rockefeller University, USA
Saturday, March 08 \| 5:00PM - 7:00PM Cell Migration This session is from Immune Response Room: Shavano Speaker 2 of 5 Ulrich H. Von Andrian, Harvard Medical School, USA T Cell Traffic and Interactions With DC in Lymphoid Tissues
Saturday, March 08 \| 5:00PM - 7:00PM Cell Migration This session is from Immune Response Room: Shavano Speaker 3 of 5 Gwendalyn J. Randolph, Washington University, USA Dendritic Cell Migration from the Periphery to Lymph Nodes and Spleen: Insights from Analysis during Atherosclerotic Disease
Saturday, March 08 \| 5:00PM - 7:00PM Cell Migration This session is from Immune Response Room: Shavano Speaker 4 of 5 Tatyana Svitkina, University of Pennsylvania, USA Actin Machinery at the Leading Edge of Migrating Cells
Saturday, March 08 \| 5:00PM - 7:00PM Cell Migration This session is from Immune Response Room: Shavano Speaker 5 of 5 Smita Nair, Duke University School of Medicine, USA Short Talk: Injection of Immature Dendritic Cells into Adjuvant Treated Skin Obviates the Need for ex vivo Maturation.
Sunday, March 09 \| 8:00AM - 11:00AM Consequences of Cell Adhesion This session is from Immune Response Room: Shavano Speaker 1 of 6 * Ralph M. Steinman, Rockefeller University, USA
Sunday, March 09 \| 8:00AM - 11:00AM Consequences of Cell Adhesion This session is from Immune Response Room: Shavano Speaker 2 of 6 Gillian Griffiths, Cambridge Institute for Medical Research, UK The Genetics of Cytotoxic T Cell Polarization and Secretion
Sunday, March 09 \| 8:00AM - 11:00AM Consequences of Cell Adhesion This session is from Immune Response Room: Shavano Speaker 3 of 6 Michael O. Hengartner, University of Zürich, Switzerland C. elegans CED Proteins and Engulfment of Apoptotic Cells
Sunday, March 09 \| 8:00AM - 11:00AM Consequences of Cell Adhesion This session is from Immune Response Room: Shavano Speaker 4 of 6 Josef M. Penninger, Institute of Molecular Biotechnology GmbH, Austria Dendritic Cells, Autoimmunity and Infectious Stimuli
Sunday, March 09 \| 8:00AM - 11:00AM Consequences of Cell Adhesion This session is from Immune Response Room: Shavano Speaker 5 of 6 Thomas M. Moran, Mount Sinai School of Medicine, USA Short Talk: Influenza Virus Induced Dendritic Cell Maturation In Vivo Correlates with Induction of Immune Responses to Co-Administered Antigen
Sunday, March 09 \| 8:00AM - 11:00AM Consequences of Cell Adhesion This session is from Immune Response Room: Shavano Speaker 6 of 6 Matthew F. Krummel, University of California, San Francisco, USA Short Talk: Functional Motor Proteins in T Cell Synapse Formation
Sunday, March 09 \| 2:00PM - 4:30PM Workshop 5: Harnessing Cell Biology During Vaccination and I mmunotherapy This session is from Immune Response Room: Shavano Speaker 1 of 14 * Jacques F. Banchereau, The Jackson Laboratory for Genomic Medicine, USA
Sunday, March 09 \| 2:00PM - 4:30PM Workshop 5: Harnessing Cell Biology During Vaccination and I mmunotherapy This session is from Immune Response Room: Shavano Speaker 2 of 14 * Ralph M. Steinman, Rockefeller University, USA
Sunday, March 09 \| 2:00PM - 4:30PM Workshop 5: Harnessing Cell Biology During Vaccination and I mmunotherapy This session is from Immune Response Room: Shavano Speaker 3 of 14 Wei Chen, University of Minnesota, USA CpG ODN Activates Human Natural Killer Cells Predominantly via an Indirect Mechanism Through Plasmacytoid Dendritic Cells
Sunday, March 09 \| 2:00PM - 4:30PM Workshop 5: Harnessing Cell Biology During Vaccination and I mmunotherapy This session is from Immune Response Room: Shavano Speaker 4 of 14 Venky Ramakrishna, Medarex, Inc., USA Targeting Antigens via CD206 Expressed on Human DCs Enables Cross-Presentation to CD8+ and CD4+ Effector T Cells
Sunday, March 09 \| 2:00PM - 4:30PM Workshop 5: Harnessing Cell Biology During Vaccination and I mmunotherapy This session is from Immune Response Room: Shavano Speaker 5 of 14 Clotilde Théry, Institut Curie, France Role of MFG-E8/lactadherin in T cell Activation by Dendritic Cell-Derived Exosomes
Sunday, March 09 \| 2:00PM - 4:30PM Workshop 5: Harnessing Cell Biology During Vaccination and I mmunotherapy This session is from Immune Response Room: Shavano Speaker 6 of 14 Raphael Clynes, Xencor, Inc., USA Role of FcgammaRII on Dendritic Cells in the Retention of Immune Complexes: A Possible Antigen-Recycling Pathway
Sunday, March 09 \| 2:00PM - 4:30PM Workshop 5: Harnessing Cell Biology During Vaccination and I mmunotherapy This session is from Immune Response Room: Shavano Speaker 7 of 14 Kate C. Agopsowicz, AltaRex Corporation, Canada Opsonization with Specific Antibodies Enhances Dendritic cell Presentation of Apoptotic Tumor Cells and Induction of CTL
Sunday, March 09 \| 2:00PM - 4:30PM Workshop 5: Harnessing Cell Biology During Vaccination and I mmunotherapy This session is from Immune Response Room: Shavano Speaker 8 of 14 Holger Kanzler, Bill & Melinda Gates Foundation, USA ISS-Antigen Conjugates Enhance MHC Class I Antigen Presentation
Sunday, March 09 \| 2:00PM - 4:30PM Workshop 5: Harnessing Cell Biology During Vaccination and I mmunotherapy This session is from Immune Response Room: Shavano Speaker 9 of 14 Hua E. Yu, Beckman Research Institute, City of Hope, USA STAT3 Activity in Tumor Cells Negatively Regulates Dendritic Cell Activation and Maturation
Sunday, March 09 \| 2:00PM - 4:30PM Workshop 5: Harnessing Cell Biology During Vaccination and I mmunotherapy This session is from Immune Response Room: Shavano Speaker 10 of 14 † Shin-Ichiro Fujii, RIKEN IMS, Japan Activation of Natural Killer Cells by alpha Galactosyl Ceramide Rapidly Induces the Full Maturation of Dendritic Cells in Mice and Thereby Acts as an Adjuvant for CD4 and CD8 T Cell Immunity to a Co-Administered Protein
Sunday, March 09 \| 2:00PM - 4:30PM Workshop 5: Harnessing Cell Biology During Vaccination and I mmunotherapy This session is from Immune Response Room: Shavano Speaker 11 of 14 Jan C. Dudda, Twincore, Germany Targeting of CD8+ T Cells to Inflamed Skin by DC Immunization
Sunday, March 09 \| 2:00PM - 4:30PM Workshop 5: Harnessing Cell Biology During Vaccination and I mmunotherapy This session is from Immune Response Room: Shavano Speaker 12 of 14 John P. Vasilakos, Biothera, USA Differential Activation of Human Innate Immune Cells using Small Molecule TLR Agonists
Sunday, March 09 \| 2:00PM - 4:30PM Workshop 5: Harnessing Cell Biology During Vaccination and I mmunotherapy This session is from Immune Response Room: Shavano Speaker 13 of 14 Gaetan Jego, Baylor Institute for Immunology Research, USA Plasmacytoid Dendritic Cells Induce B and T Cell Memory Responses
Sunday, March 09 \| 2:00PM - 4:30PM Workshop 5: Harnessing Cell Biology During Vaccination and I mmunotherapy This session is from Immune Response Room: Shavano Speaker 14 of 14 † Beatrice Laupeze, Baylor Institute for Immunology Research, USA Different Dendritic Cells can Induce Different Types of T Cell Responses
Sunday, March 09 \| 5:00PM - 7:00PM Cellular Mechanisms of Immune Evasion This session is from Immune Response Room: Shavano Speaker 1 of 5 * Ralph M. Steinman, Rockefeller University, USA
Sunday, March 09 \| 5:00PM - 7:00PM Cellular Mechanisms of Immune Evasion This session is from Immune Response Room: Shavano Speaker 2 of 5 Robert D. Schreiber, Washington University School of Medicine, USA The Three E’s of Cancer Immunoediting
Sunday, March 09 \| 5:00PM - 7:00PM Cellular Mechanisms of Immune Evasion This session is from Immune Response Room: Shavano Speaker 3 of 5 Tak W. Mak, Campbell Family Institute for Breast Cancer, Canada Genetic Dissection of Lymphocyte Activation
Sunday, March 09 \| 5:00PM - 7:00PM Cellular Mechanisms of Immune Evasion This session is from Immune Response Room: Shavano Speaker 4 of 5 Benoît J. Van den Eynde, University of Louvain, Belgium A Novel Tumor Immune Escape Mechanism based on tryptophan Degradation by Indoleamine 2,3 Dioxygenase
Sunday, March 09 \| 5:00PM - 7:00PM Cellular Mechanisms of Immune Evasion This session is from Immune Response Room: Shavano Speaker 5 of 5 Eric C. Bartee, Oregon Health & Science University, USA Short Talk: Downregulation of Cell Surface Receptors by a Family of Human Ubiquitin Ligases Homologous to Viral Immune Evasion Proteins