Web Desc
Dendritic Cells: Interfaces with Immunobiology and Medicine
joint with Cell Biology of the Immune Response
Organizer(s): Ralph M. Steinman, Anne O’Garra and Jacques Banchereau
Date: March 03 - 08, 2003
Location: Keystone Resort, Keystone, CO, USA
Supported by Keystone Symposia
For important information on the coronavirus, please click here
Summary of Meeting:
Dendritic cells control the immune system from different vantage points. Dendritic cells control the responses of several types of lymphocytes; the transition between innate and adaptive immunity; the quality of the T cell response including Th1 polarization, memory, and even tolerance; and immunology in many clinical settings. This multidisciplinary meeting will develop the following areas: 1) vaccination and immune therapy, including the manipulation of dendritic cell function in vivo; 2) interactions of dendritic cells with microbial pathogens including the many innate functions of dendritic cells; 3) the early response of different types of lymphocytes to dendritic cells, and the organization of this response in vivo; 4) the role of dendritic cells in different forms of peripheral tolerance and the regulation of autoimmunity; 5) the specialized properties of dendritic cells in antigen handling, processing and presentation. As has been the case in prior Keystone symposia on dendritic cells, there will be an equal number of presentations invited speakers and speakers selected from the abstracts.
Discounted Abstract Deadline: November 5 2002
Discounted Registration Deadline: January 6 2003
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1 R13 AI053904-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Monday, March 03 | 3:00PM - 7:00PM
Registration
Room: Shavano Peak Foyer


Monday, March 03 | 6:15PM - 7:15PM
Welcome
Room: Shavano Peak Foyer


Monday, March 03 | 7:15PM - 7:30PM
Orientation
Room: Shavano/Torreys


Tuesday, March 04 | 7:00AM - 8:00AM
Breakfast
Room: Crestone/Red Cloud


Tuesday, March 04 | 8:00AM - 11:00AM
Dendritic Cells and the Control of Immunity vs. Tolerance
Room: Shavano/Torreys

Speaker 1 of 4
Yong-Jun Liu, Sanofi, USA
Human Epithelial Cells Trigger Dendritic Cell-Mediated Allergic Inflammation by Producing TSLP

Tuesday, March 04 | 8:00AM - 11:00AM
Dendritic Cells and the Control of Immunity vs. Tolerance
Room: Shavano/Torreys

Speaker 2 of 4
Kayo Inaba, Kyoto University, Japan
Peripheral Tolerance via DCs in vivo

Tuesday, March 04 | 8:00AM - 11:00AM
Dendritic Cells and the Control of Immunity vs. Tolerance
Room: Shavano/Torreys

Speaker 3 of 4
Maria Grazia Roncarolo, Stanford University School of Medicine, USA
Role of Regulatory T Cells in Immunological Tolerance

Tuesday, March 04 | 8:00AM - 11:00AM
Dendritic Cells and the Control of Immunity vs. Tolerance
Room: Shavano/Torreys

Speaker 4 of 4
* Anne O'Garra, Francis Crick Institute, UK
Flexibility of Mouse Classical and Plasmacytoid-Derived Dendritic Cells in Directing Th1 and Th2 Cell Development: Dependency on Antigen Dose and Differential Toll-Like Receptor Ligation

Tuesday, March 04 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Tuesday, March 04 | 11:00AM - 1:00PM
Poster Setup
Room: Longs Peak/Grays Peak


Tuesday, March 04 | 1:00PM - 10:00PM
Poster Viewing
Room: Longs Peak/Grays Peak


Tuesday, March 04 | 2:00PM - 4:30PM
Workshop 1: Immunity and Tolerance to Tumors
Room: Shavano/Torreys

Speaker 1 of 10
* Olivera J. Finn, University of Pittsburgh School of Medicine, USA

Tuesday, March 04 | 2:00PM - 4:30PM
Workshop 1: Immunity and Tolerance to Tumors
Room: Shavano/Torreys

Speaker 2 of 10
Shu-Hsia Chen, Mount Sinai School of Medicine, USA
Regulation of Dendritic Cell Function by NK Cells: Mechanisms Underlying the Synergism between IL-12 and 4-1 BB Activation

Tuesday, March 04 | 2:00PM - 4:30PM
Workshop 1: Immunity and Tolerance to Tumors
Room: Shavano/Torreys

Speaker 3 of 10
Michael D. Gunn, Duke University Medical Center, USA
Splenic Immature PDC Induce the Development of IL-10 Producing CD4+ T Regulatory Cells

Tuesday, March 04 | 2:00PM - 4:30PM
Workshop 1: Immunity and Tolerance to Tumors
Room: Shavano/Torreys

Speaker 4 of 10
Michael R. Shurin, University of Pittsburgh, USA
Small Rho GTPases Regulate Dendropoiesis in Cancer

Tuesday, March 04 | 2:00PM - 4:30PM
Workshop 1: Immunity and Tolerance to Tumors
Room: Shavano/Torreys

Speaker 5 of 10
Sally Ann Litherland, Florida Hospital Cancer Institute, USA
STAT5 Dysfunction in Autoimmune Myeloid Antigen Presenting Cell Activation and Differentiation

Tuesday, March 04 | 2:00PM - 4:30PM
Workshop 1: Immunity and Tolerance to Tumors
Room: Shavano/Torreys

Speaker 6 of 10
Mariolina Salio, Weatherall Institute of Molecular Medicine, UK
Efficacy of Murine Myeloid and Plasmacytoid Dendritic Cells in Eliciting Adaptive Immune Responses

Tuesday, March 04 | 2:00PM - 4:30PM
Workshop 1: Immunity and Tolerance to Tumors
Room: Shavano/Torreys

Speaker 7 of 10
Heather Zwickey, National College of Naturopathic Medicine, USA
DCs Presenting Self Antigens: Tolerance or Activation?

Tuesday, March 04 | 2:00PM - 4:30PM
Workshop 1: Immunity and Tolerance to Tumors
Room: Shavano/Torreys

Speaker 8 of 10
Mohamad Mohty, CHU de Nantes/INSERM U892, France
Interferon-Alpha Skews Monocyte Differentiation into Toll-like Receptor 7 Expressing Dendritic Cells with Potent Functional Activities

Tuesday, March 04 | 2:00PM - 4:30PM
Workshop 1: Immunity and Tolerance to Tumors
Room: Shavano/Torreys

Speaker 9 of 10
Hubert Eng, Virexx Inc., Canada
Complexation with Murine MAb-B43.13 Alters the Endocytic Trafficking of the Mucinous Tumor Antigen CA125 after Uptake by Human Dendritic Cells

Tuesday, March 04 | 2:00PM - 4:30PM
Workshop 1: Immunity and Tolerance to Tumors
Room: Shavano/Torreys

Speaker 10 of 10
Alexandra M. Livingstone, University of Rochester Medical Center, USA
Helper-Dependent CD8+ T Cell Memory Requires CD40 Expression on the Immunizing Dendritic Cell, but Not on CD4+ or CD8+ T Cells.

Tuesday, March 04 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Longs Peak Foyer


Tuesday, March 04 | 5:00PM - 7:00PM
Dendritic Cell Maturation in vivo
Room: Shavano/Torreys

Speaker 1 of 4
* Anne O'Garra, Francis Crick Institute, UK

Tuesday, March 04 | 5:00PM - 7:00PM
Dendritic Cell Maturation in vivo
Room: Shavano/Torreys

Speaker 2 of 4
David F. Tough, Edward Jenner Institute for Vaccine Research, UK
Regulation of Immune Responses by Type I Interferon

Tuesday, March 04 | 5:00PM - 7:00PM
Dendritic Cell Maturation in vivo
Room: Shavano/Torreys

Speaker 3 of 4
A. Karolina Palucka, The Jackson Laboratory for Genomic Medicine, USA
Dendritic Cells as Melanoma Vaccines

Tuesday, March 04 | 5:00PM - 7:00PM
Dendritic Cell Maturation in vivo
Room: Shavano/Torreys

Speaker 4 of 4
Masaru Taniguchi, RIKEN RCAI, Japan
Regulatory Interaction between Valpha14 NKT Cells and Dendritic Cells

Tuesday, March 04 | 7:00PM - 8:00PM
Social Hour
Room: Longs Peak/Grays Peak


Tuesday, March 04 | 8:00PM - 10:00PM
Poster Session 1: DCs in Immunity and Tolerance
Room: Longs Peak/Grays Peak


Wednesday, March 05 | 7:00AM - 8:00AM
Breakfast
Room: Crestone/Red Cloud


Wednesday, March 05 | 8:00AM - 11:00AM
Antigen Capture by DC in situ
Room: Shavano/Torreys

Speaker 1 of 5
* Jacques F. Banchereau, The Jackson Laboratory for Genomic Medicine, USA

Wednesday, March 05 | 8:00AM - 11:00AM
Antigen Capture by DC in situ
Room: Shavano/Torreys

Speaker 2 of 5
Michel C. Nussenzweig, HHMI/Rockefeller University, USA
Targeting Antigens to Lymphoid Tissue DCs

Wednesday, March 05 | 8:00AM - 11:00AM
Antigen Capture by DC in situ
Room: Shavano/Torreys

Speaker 3 of 5
Marc K. Jenkins, University of Minnesota Medical School, USA
In Vivo Analysis of Antigen-Presentation to CD4 T Cells

Wednesday, March 05 | 8:00AM - 11:00AM
Antigen Capture by DC in situ
Room: Shavano/Torreys

Speaker 4 of 5
Giorgio Trinchieri, NCI, National Institutes of Health, USA
Physiology of Mouse Interferon Producing Cells

Wednesday, March 05 | 8:00AM - 11:00AM
Antigen Capture by DC in situ
Room: Shavano/Torreys

Speaker 5 of 5
Akiko Iwasaki, HHMI/Yale University School of Medicine, USA
Short Talk: Primary Role of Vaginal Dendritic Cells in Th1 Induction during Genital Herpes Simplex Virus-2 Infection

Wednesday, March 05 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Wednesday, March 05 | 11:00AM - 1:00PM
Poster Setup
Room: Longs Peak/Grays Peak


Wednesday, March 05 | 1:00PM - 10:00PM
Poster Viewing
Room: Longs Peak/Grays Peak


Wednesday, March 05 | 2:00PM - 4:30PM
Workshop 2: DC Capture of Antigens and Pathogens
Room: Shavano/Torreys

Speaker 1 of 12
* Alan Sher, NIAID, National Institutes of Health, USA

Wednesday, March 05 | 2:00PM - 4:30PM
Workshop 2: DC Capture of Antigens and Pathogens
Room: Shavano/Torreys

Speaker 2 of 12
* Paola Ricciardi-Castagnoli, Toscana Life Science Foundation, Italy

Wednesday, March 05 | 2:00PM - 4:30PM
Workshop 2: DC Capture of Antigens and Pathogens
Room: Shavano/Torreys

Speaker 3 of 12
Li-Yun Coty Huang, U.S. Food and Drug Administration, USA
Brucella abortus Activates Dendritic Cells and Splenocytes to Secrete IL-12p40 and TNFalpha via Different Toll-Like Receptors

Wednesday, March 05 | 2:00PM - 4:30PM
Workshop 2: DC Capture of Antigens and Pathogens
Room: Shavano/Torreys

Speaker 4 of 12
Marina N. Fleeton, National Institutes of Health, USA
CD11blo/CD8alpha- Peyer’s Patch Dendritic Cells Process Epithelial Cell-Associated Viral Antigens following Infection with Reovirus, Type 1 Lang

Wednesday, March 05 | 2:00PM - 4:30PM
Workshop 2: DC Capture of Antigens and Pathogens
Room: Shavano/Torreys

Speaker 5 of 12
Amy C. Herring, University of Michigan, USA
The Role of Pulmonary Dendritic Cells in the Developing T1 Response to Cryptococcus neoformans Infection

Wednesday, March 05 | 2:00PM - 4:30PM
Workshop 2: DC Capture of Antigens and Pathogens
Room: Shavano/Torreys

Speaker 6 of 12
W. L. William Chang, University of California, Davis, USA
Alteration of Dendritic Cell Maturation and Functions by Cytomegalovirus-Encoded Interleukin-10

Wednesday, March 05 | 2:00PM - 4:30PM
Workshop 2: DC Capture of Antigens and Pathogens
Room: Shavano/Torreys

Speaker 7 of 12
Christopher M. Smith, Walter and Eliza Hall Institute of Medical Research, Australia
Conventional CD8a+ Dendritic Cells Prime CTL Immunity to Cutaneous Herpes Simplex Virus-1 Infection

Wednesday, March 05 | 2:00PM - 4:30PM
Workshop 2: DC Capture of Antigens and Pathogens
Room: Shavano/Torreys

Speaker 8 of 12
Gabriele Pollara, University College London, UK
Dendritic Cell Innate Responses to HSV Infection

Wednesday, March 05 | 2:00PM - 4:30PM
Workshop 2: DC Capture of Antigens and Pathogens
Room: Shavano/Torreys

Speaker 9 of 12
Kevin L. Legge, University of Iowa Carver College of Medicine, USA
Respiratory Dendritic Cell Trafficking to the Regional Lymph Nodes is Limited to the Early Stage of Experimental Influenza Infection

Wednesday, March 05 | 2:00PM - 4:30PM
Workshop 2: DC Capture of Antigens and Pathogens
Room: Shavano/Torreys

Speaker 10 of 12
Maria Rescigno, Humanitas University, Italy
Bacteria Impede the Migratory Clearance and the Differentiation of Monocytes into Dendritic Cells to Lymph Nodes and Thereby Limit the Development of Adaptive Immune Responses

Wednesday, March 05 | 2:00PM - 4:30PM
Workshop 2: DC Capture of Antigens and Pathogens
Room: Shavano/Torreys

Speaker 11 of 12
Leopoldo Flores-Romo, El Centro de Investigación y de Estudios Avanzados del IPN, Mexico
Cutaneous Langerhans Dendritic Cells in a Murine Model of Leprosy: in vivo Analysis

Wednesday, March 05 | 2:00PM - 4:30PM
Workshop 2: DC Capture of Antigens and Pathogens
Room: Shavano/Torreys

Speaker 12 of 12
Anne Hosmalin, Institut Cochin, Inserm U1016, Université Paris Descartes, France
Processing of an HIV-1 Immunodominant Restricted Epitope by the Cytosolic Protease TPPII

Wednesday, March 05 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Longs Peak Foyer


Wednesday, March 05 | 5:00PM - 7:00PM
Exogenous Pathway and Cross-Presentation
Room: Shavano/Torreys

Speaker 1 of 9
* Jacques F. Banchereau, The Jackson Laboratory for Genomic Medicine, USA

Wednesday, March 05 | 5:00PM - 7:00PM
Exogenous Pathway and Cross-Presentation
Room: Shavano/Torreys

Speaker 2 of 9
Michael J. Bevan, HHMI/University of Washington, USA
Maintaining memory

Wednesday, March 05 | 5:00PM - 7:00PM
Exogenous Pathway and Cross-Presentation
Room: Shavano/Torreys

Speaker 3 of 9
Sebastian Amigorena, Institut Curie, France
Exogenous Pathway via Fc Receptors

Wednesday, March 05 | 5:00PM - 7:00PM
Exogenous Pathway and Cross-Presentation
Room: Shavano/Torreys

Speaker 4 of 9
Philippe D. Pierre, Centre d'Immunologie Marseille-Luminy, CIML, France
Aggregation in Maturing DCs, A Mean to Segregate Self Antigens from the Proteasome

Wednesday, March 05 | 5:00PM - 7:00PM
Exogenous Pathway and Cross-Presentation
Room: Shavano/Torreys

Speaker 5 of 9
Carl G. Figdor, Radboud University Medical Center, Netherlands
Short Talk: The C-Type Lectin DC-SIGN (CD209) is an Antigen Uptake Receptor for Candida albicans on Dendritic Cells

Wednesday, March 05 | 5:00PM - 7:00PM
Exogenous Pathway and Cross-Presentation
Room: Shavano/Torreys

Speaker 6 of 9
Stefan Freigang, University Hospital Zurich, Switzerland
Short Talk: Endogenous Neosynthesis Versus Cross-Presentation of Polioviral Antigen for CTL Priming

Wednesday, March 05 | 5:00PM - 7:00PM
Exogenous Pathway and Cross-Presentation
Room: Shavano/Torreys

Speaker 7 of 9
Maria Carmen Ramirez Mazcunyan, Fox Chase Cancer Center, USA
Short Talk: Macrophages and Dendritic Cells Use the Cytosolic Pathway to Rapidly Cross-Present Antigen from Live, Vaccinia-Infected Cells

Wednesday, March 05 | 5:00PM - 7:00PM
Exogenous Pathway and Cross-Presentation
Room: Shavano/Torreys

Speaker 8 of 9
Nicolas Glaichenhaus, Centre National de la Recherche Scientifique, France
Short Talk: CD11b+ Dendritic Cells are Responsible for the Activation of CD4+ T Cells in Mice Infected with the Intracellular Parasite Leishmania Major

Wednesday, March 05 | 5:00PM - 7:00PM
Exogenous Pathway and Cross-Presentation
Room: Shavano/Torreys

Speaker 9 of 9
Lélia Delamarre, Genentech, Inc., USA
Short Talk: Presentation of Exogenous Antigens on MHC I and MHC II is Differentially Regulated during Dendritic Cell Maturation

Wednesday, March 05 | 7:00PM - 8:00PM
Social Hour
Room: Longs Peak/Grays Peak


Wednesday, March 05 | 8:00PM - 10:00PM
Poster Session 2: DC Subsets, Maturation and Immune Response
s in vivo
Room: Longs Peak/Grays Peak


Thursday, March 06 | 7:00AM - 8:00AM
Breakfast
Room: Crestone/Red Cloud


Thursday, March 06 | 8:00AM - 11:00AM
Transmission of Signals to the Nucleus: General Principles (
Joint)

Room: Shavano/Torreys

Speaker 1 of 6
Joseph Schlessinger, Yale University School of Medicine, USA
Tyrosine Kinases

Thursday, March 06 | 8:00AM - 11:00AM
Transmission of Signals to the Nucleus: General Principles (
Joint)

Room: Shavano/Torreys

Speaker 2 of 6
Amer A. Beg, Moffitt Cancer Center, USA
NF-kappaB Signaling in Dendritic Cells

Thursday, March 06 | 8:00AM - 11:00AM
Transmission of Signals to the Nucleus: General Principles (
Joint)

Room: Shavano/Torreys

Speaker 3 of 6
* Richard A. Flavell, HHMI/Yale University School of Medicine, USA
Signal-Mediated Control of Transcription

Thursday, March 06 | 8:00AM - 11:00AM
Transmission of Signals to the Nucleus: General Principles (
Joint)

Room: Shavano/Torreys

Speaker 4 of 6
Gioacchino Natoli, Humanitas University, Italy
Close-Ups of NF-kappaB Recruitment to Target Genes in DCs

Thursday, March 06 | 8:00AM - 11:00AM
Transmission of Signals to the Nucleus: General Principles (
Joint)

Room: Shavano/Torreys

Speaker 5 of 6
Takashi Kobayashi, University of Pennsylvania, USA
Short Talk: TRAF6 Regulates Dendritic Cell Development and Function

Thursday, March 06 | 8:00AM - 11:00AM
Transmission of Signals to the Nucleus: General Principles (
Joint)

Room: Shavano/Torreys

Speaker 6 of 6
Salome Landmann, Centre Medical Universitaire, Switzerland
Short Talk: The Role of the Class II Transactivator (CIITA) in Dendritic Cells

Thursday, March 06 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Thursday, March 06 | 11:00AM - 1:00PM
Poster Setup
Room: Longs Peak/Grays Peak


Thursday, March 06 | 1:00PM - 10:00PM
Poster Viewing
Room: Longs Peak/Grays Peak


Thursday, March 06 | 2:00PM - 4:30PM
Workshop 3: Rafts: Fact or Fiction? (Joint)
Room: Shavano/Torreys

Speaker 1 of 8
* † Derek Toomre, Yale University School of Medicine, USA

Thursday, March 06 | 2:00PM - 4:30PM
Workshop 3: Rafts: Fact or Fiction? (Joint)
Room: Shavano/Torreys

Speaker 2 of 8
Christian O. Meyer zum Buschenfelde, Yale University, USA
Recruitment of CD28 and CD86 to Lipid Rafts during DC-T Cell Interaction Results in Efficient T Cell Priming

Thursday, March 06 | 2:00PM - 4:30PM
Workshop 3: Rafts: Fact or Fiction? (Joint)
Room: Shavano/Torreys

Speaker 3 of 8
Jeoung-Sook Shin, University of California, San Francisco, USA
Mast Cell Endo/Exocytosis Of Particulate Allergens

Thursday, March 06 | 2:00PM - 4:30PM
Workshop 3: Rafts: Fact or Fiction? (Joint)
Room: Shavano/Torreys

Speaker 4 of 8
Neil Poloso, Allergan Inc., USA
Kinetics of MHC Class II Complex Association with Lipid Rafts

Thursday, March 06 | 2:00PM - 4:30PM
Workshop 3: Rafts: Fact or Fiction? (Joint)
Room: Shavano/Torreys

Speaker 5 of 8
Lee Leserman, Centre d'Immunologie de Marseille-Luminy, France
MHC Class II/Peptide Complexes in Lipid Microdomains at the Dendritic Cell Surface Initiate the TH1 CD4 T Cell Phenotype

Thursday, March 06 | 2:00PM - 4:30PM
Workshop 3: Rafts: Fact or Fiction? (Joint)
Room: Shavano/Torreys

Speaker 6 of 8
Richard M. Siegel, NIAMS, National Institutes of Health, USA
Life and Death Decisions in TLR and TNF Family Receptor Signaling

Thursday, March 06 | 2:00PM - 4:30PM
Workshop 3: Rafts: Fact or Fiction? (Joint)
Room: Shavano/Torreys

Speaker 7 of 8
Alessandra Cambi, Max Planck Institute for Biophysical Chemistry, Germany
Distribution of LFA-1 and DC-SIGN in Microdomains on DC by High Resolution Microscopy: Consequences for Cell-Adhesion and Ligand Binding

Thursday, March 06 | 2:00PM - 4:30PM
Workshop 3: Rafts: Fact or Fiction? (Joint)
Room: Shavano/Torreys

Speaker 8 of 8
Juli J. Unternaehrer, Children's Hospital Boston, USA
Surface MHC-II I-E Associates with I-A in Dendritic Cells but Not in B Cells

Thursday, March 06 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Longs Peak Foyer


Thursday, March 06 | 5:00PM - 7:00PM
Signal Transduction and Antigen Presentation (Joint)
Room: Shavano/Torreys

Speaker 1 of 5
* Richard A. Flavell, HHMI/Yale University School of Medicine, USA

Thursday, March 06 | 5:00PM - 7:00PM
Signal Transduction and Antigen Presentation (Joint)
Room: Shavano/Torreys

Speaker 2 of 5
Tsuneyasu Kaisho, RIKEN Research Center for Allergy and Immunology, Japan
Pleiotropic Function of Toll-Like Receptors on Dendritic Cells

Thursday, March 06 | 5:00PM - 7:00PM
Signal Transduction and Antigen Presentation (Joint)
Room: Shavano/Torreys

Speaker 3 of 5
Alan Aderem, Center for Infectious Disease Research, USA
Macrophage Phagocytosis: from Genes to Function

Thursday, March 06 | 5:00PM - 7:00PM
Signal Transduction and Antigen Presentation (Joint)
Room: Shavano/Torreys

Speaker 4 of 5
Ruslan Medzhitov, HHMI/Yale University School of Medicine, USA
Toll Pathway of Host Defense

Thursday, March 06 | 5:00PM - 7:00PM
Signal Transduction and Antigen Presentation (Joint)
Room: Shavano/Torreys

Speaker 5 of 5
Caetano Reis e Sousa, Francis Crick Institute, UK
Short Talk: Non-Plasmacytoid Dendritic Cells Act as Interferon-Producing Cells in Response to Cytosolic Double-Stranded RNA

Thursday, March 06 | 7:00PM - 8:00PM
Social Hour
Room: Longs Peak/Grays Peak


Thursday, March 06 | 8:00PM - 10:00PM
Poster Session 3: Signal Transduction
Room: Longs Peak/Grays Peak


Friday, March 07 | 7:00AM - 8:00AM
Breakfast
Room: Crestone/Red Cloud


Friday, March 07 | 8:00AM - 11:00AM
Endocytosis and Lysosomal Transport (Joint)
Room: Shavano/Torreys

Speaker 1 of 7
* Ira Mellman, Genentech, Inc., USA

Friday, March 07 | 8:00AM - 11:00AM
Endocytosis and Lysosomal Transport (Joint)
Room: Shavano/Torreys

Speaker 2 of 7
Scott D. Emr, Cornell University, USA
Receptor Down-Regulation and Protein Sorting at the Multivesicular Body

Friday, March 07 | 8:00AM - 11:00AM
Endocytosis and Lysosomal Transport (Joint)
Room: Shavano/Torreys

Speaker 3 of 7
Margaret S. Robinson, University of Cambridge, UK
Coat Proteins and Sorting

Friday, March 07 | 8:00AM - 11:00AM
Endocytosis and Lysosomal Transport (Joint)
Room: Shavano/Torreys

Speaker 4 of 7
Suzanne R. Pfeffer, Stanford University, USA
Rab GTPases in Receptor Trafficking

Friday, March 07 | 8:00AM - 11:00AM
Endocytosis and Lysosomal Transport (Joint)
Room: Shavano/Torreys

Speaker 5 of 7
Giorgio Scita, IFOM Foundation at Campus IFOM-IEO, Italy
Integration of Signals Leading to Actin Remodeling and Endocytosis

Friday, March 07 | 8:00AM - 11:00AM
Endocytosis and Lysosomal Transport (Joint)
Room: Shavano/Torreys

Speaker 6 of 7
Angela Stoddart, University of California, San Francisco, USA
Short Talk: Deciphering the Roles of Lipid Rafts and Clathrin in BCR Internalization

Friday, March 07 | 8:00AM - 11:00AM
Endocytosis and Lysosomal Transport (Joint)
Room: Shavano/Torreys

Speaker 7 of 7
Haoran Zhao, Genentech, USA
Short Talk: TRAC-1, A Novel Lymphocyte-Specific E3 Ubiquitin Ligase, Regulates T Cell Activation Downstream of TCR Engagement

Friday, March 07 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Friday, March 07 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Longs Peak Foyer


Friday, March 07 | 5:00PM - 7:00PM
Mechanisms of Proteolysis in the Cytosol (Joint)
Room: Shavano/Torreys

Speaker 1 of 4
* Ira Mellman, Genentech, Inc., USA

Friday, March 07 | 5:00PM - 7:00PM
Mechanisms of Proteolysis in the Cytosol (Joint)
Room: Shavano/Torreys

Speaker 2 of 4
Wolfgang P. Baumeister, Max Planck Institute of Biochemistry, Germany
Electron Tomography: Visualizing Macromolecular Complexes in Intact Cells

Friday, March 07 | 5:00PM - 7:00PM
Mechanisms of Proteolysis in the Cytosol (Joint)
Room: Shavano/Torreys

Speaker 3 of 4
Jack R. Bennink, NIAID, National Institutes of Health, USA
The Origin of Antigenic Peptides and Proteasomal Degradation of Newly Synthesized Proteins

Friday, March 07 | 5:00PM - 7:00PM
Mechanisms of Proteolysis in the Cytosol (Joint)
Room: Shavano/Torreys

Speaker 4 of 4
Alfred L. Goldberg, Harvard Medical School, USA
Peptidases that Function after the Proteasome and Regulate Antigen Presentation

Friday, March 07 | 7:00PM - 8:00PM
Social Hour
Room: Longs Peak/Grays Peak


Friday, March 07 | 8:00PM - 11:00PM
Entertainment
Room: Longs Peak/Grays Peak


Saturday, March 08 | 8:00AM - 11:00AM
Functional Specializations of the Endocytic Pathway
This session is from Immune Response
Room: Shavano

Speaker 1 of 7
* Ralph M. Steinman, Rockefeller University, USA


Saturday, March 08 | 8:00AM - 11:00AM
Functional Specializations of the Endocytic Pathway
This session is from Immune Response
Room: Shavano

Speaker 2 of 7
Christopher V. Nicchitta, Duke University School of Medicine, USA
Heat Shock Proteins and Antigen Presentation


Saturday, March 08 | 8:00AM - 11:00AM
Functional Specializations of the Endocytic Pathway
This session is from Immune Response
Room: Shavano

Speaker 3 of 7
Sergio Grinstein, Hospital for Sick Children, Canada
Role of Phosphoinositides in Phagosome Formation and in Bacterial Invasion


Saturday, March 08 | 8:00AM - 11:00AM
Functional Specializations of the Endocytic Pathway
This session is from Immune Response
Room: Shavano

Speaker 4 of 7
Dorothee Schmid, Rockefeller University, USA
Short Talk: A Novel Pathway for Endogenous MHC Class II Presentation of a Nuclear Viral Antigen that Involves Autophagy


Saturday, March 08 | 8:00AM - 11:00AM
Functional Specializations of the Endocytic Pathway
This session is from Immune Response
Room: Shavano

Speaker 5 of 7
Dan R. Littman, HHMI/New York University School of Medicine, USA
DC-SIGN and Transmission of HIV-1 Following Endocytosis


Saturday, March 08 | 8:00AM - 11:00AM
Functional Specializations of the Endocytic Pathway
This session is from Immune Response
Room: Shavano

Speaker 6 of 7
Eduardo Sergio Trombetta, Yale University, USA
Regulation of Lysosomal Function in Dendritic Cells


Saturday, March 08 | 8:00AM - 11:00AM
Functional Specializations of the Endocytic Pathway
This session is from Immune Response
Room: Shavano

Speaker 7 of 7
Thomas J. Hope, Northwestern University, USA
Short Talk: Enhancement of HIV Infection by Dendritic Cells: Transfer of HIV to Target Cells Through an Infectious Synapse


Saturday, March 08 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.

Saturday, March 08 | 2:00PM - 4:30PM
Workshop 4: Mechanisms of Antigen Processing and Presentatio
n
This session is from Immune Response
Room: Shavano

Speaker 1 of 12
* Hans-Georg Rammensee, University of Tübingen, Germany


Saturday, March 08 | 2:00PM - 4:30PM
Workshop 4: Mechanisms of Antigen Processing and Presentatio
n
This session is from Immune Response
Room: Shavano

Speaker 2 of 12
* Ira Mellman, Genentech, Inc., USA


Saturday, March 08 | 2:00PM - 4:30PM
Workshop 4: Mechanisms of Antigen Processing and Presentatio
n
This session is from Immune Response
Room: Shavano

Speaker 3 of 12
Deborah Palliser, Takeda, USA
Delineation of the Pathway Taken by a Heat Shock Fusion Protein to Gain Access to the MHC Class I Processing Pathway in Dendritic Cells


Saturday, March 08 | 2:00PM - 4:30PM
Workshop 4: Mechanisms of Antigen Processing and Presentatio
n
This session is from Immune Response
Room: Shavano

Speaker 4 of 12
Dorian B. McGavern, NINDS, National Institutes of Health, USA
Visualizing Antigen-Specific T Cells Involved in Immunopathogenesis


Saturday, March 08 | 2:00PM - 4:30PM
Workshop 4: Mechanisms of Antigen Processing and Presentatio
n
This session is from Immune Response
Room: Shavano

Speaker 5 of 12
Scott A. Wetzel, University of Montana, USA
Peptide Specific Transfer of MHC From APC to T cells Through the Immunological Synapse


Saturday, March 08 | 2:00PM - 4:30PM
Workshop 4: Mechanisms of Antigen Processing and Presentatio
n
This session is from Immune Response
Room: Shavano

Speaker 6 of 12
Heiichiro Udono, Nagasaki University, Japan
Two Distinct Pathways Mediated by PA28 and hsp90 in Antigen Processing that is Linked with MHC I Polymorphism


Saturday, March 08 | 2:00PM - 4:30PM
Workshop 4: Mechanisms of Antigen Processing and Presentatio
n
This session is from Immune Response
Room: Shavano

Speaker 7 of 12
Michael F. Princiotta, Advaxis, Inc, USA
Quantitating Viral Protein Synthesis, Degradation and Endogenous Antigen Processing


Saturday, March 08 | 2:00PM - 4:30PM
Workshop 4: Mechanisms of Antigen Processing and Presentatio
n
This session is from Immune Response
Room: Shavano

Speaker 8 of 12
Ona E. Bloom, Yale University School of Medicine, USA
Spinophilin, a Neuronal Protein at the Immunological Synapse


Saturday, March 08 | 2:00PM - 4:30PM
Workshop 4: Mechanisms of Antigen Processing and Presentatio
n
This session is from Immune Response
Room: Shavano

Speaker 9 of 12
Julie Magarian Blander, Weill Cornell Medicine, Cornell University, USA
Signals from Toll-Like Receptors Control Phagolysosomal Fusion


Saturday, March 08 | 2:00PM - 4:30PM
Workshop 4: Mechanisms of Antigen Processing and Presentatio
n
This session is from Immune Response
Room: Shavano

Speaker 10 of 12
Babak Javid, Tsinghua University School of Medicine, China
Efficient Cross-Presentation of Mycobacterial Heat Shock Protein / Antigen Complexes by Human Dendritic Cells


Saturday, March 08 | 2:00PM - 4:30PM
Workshop 4: Mechanisms of Antigen Processing and Presentatio
n
This session is from Immune Response
Room: Shavano

Speaker 11 of 12
Wilfred A. Jefferies, University of British Columbia, Canada
The Cytoplasmic Domain of MHC Class I Proteins Controls Intracellular Trafficking and Cross-Presentation


Saturday, March 08 | 2:00PM - 4:30PM
Workshop 4: Mechanisms of Antigen Processing and Presentatio
n
This session is from Immune Response
Room: Shavano

Speaker 12 of 12
Marco A. Purbhoo, Howard Hughes Medical Institute, USA
Differential Dynamics of CD8, TCR, and MHC at the Immunological Synapse


Saturday, March 08 | 5:00PM - 7:00PM
Cell Migration
This session is from Immune Response
Room: Shavano

Speaker 1 of 5
* Ralph M. Steinman, Rockefeller University, USA


Saturday, March 08 | 5:00PM - 7:00PM
Cell Migration
This session is from Immune Response
Room: Shavano

Speaker 2 of 5
Ulrich H. Von Andrian, Harvard Medical School, USA
T Cell Traffic and Interactions With DC in Lymphoid Tissues


Saturday, March 08 | 5:00PM - 7:00PM
Cell Migration
This session is from Immune Response
Room: Shavano

Speaker 3 of 5
Gwendalyn J. Randolph, Washington University, USA
Dendritic Cell Migration from the Periphery to Lymph Nodes and Spleen: Insights from Analysis during Atherosclerotic Disease


Saturday, March 08 | 5:00PM - 7:00PM
Cell Migration
This session is from Immune Response
Room: Shavano

Speaker 4 of 5
Tatyana Svitkina, University of Pennsylvania, USA
Actin Machinery at the Leading Edge of Migrating Cells


Saturday, March 08 | 5:00PM - 7:00PM
Cell Migration
This session is from Immune Response
Room: Shavano

Speaker 5 of 5
Smita Nair, Duke University School of Medicine, USA
Short Talk: Injection of Immature Dendritic Cells into Adjuvant Treated Skin Obviates the Need for ex vivo Maturation.


Sunday, March 09 | 8:00AM - 11:00AM
Consequences of Cell Adhesion
This session is from Immune Response
Room: Shavano

Speaker 1 of 6
* Ralph M. Steinman, Rockefeller University, USA


Sunday, March 09 | 8:00AM - 11:00AM
Consequences of Cell Adhesion
This session is from Immune Response
Room: Shavano

Speaker 2 of 6
Gillian Griffiths, Cambridge Institute for Medical Research, UK
The Genetics of Cytotoxic T Cell Polarization and Secretion


Sunday, March 09 | 8:00AM - 11:00AM
Consequences of Cell Adhesion
This session is from Immune Response
Room: Shavano

Speaker 3 of 6
Michael O. Hengartner, University of Zürich, Switzerland
C. elegans CED Proteins and Engulfment of Apoptotic Cells


Sunday, March 09 | 8:00AM - 11:00AM
Consequences of Cell Adhesion
This session is from Immune Response
Room: Shavano

Speaker 4 of 6
Josef M. Penninger, Institute of Molecular Biotechnology GmbH, Austria
Dendritic Cells, Autoimmunity and Infectious Stimuli


Sunday, March 09 | 8:00AM - 11:00AM
Consequences of Cell Adhesion
This session is from Immune Response
Room: Shavano

Speaker 5 of 6
Thomas M. Moran, Mount Sinai School of Medicine, USA
Short Talk: Influenza Virus Induced Dendritic Cell Maturation In Vivo Correlates with Induction of Immune Responses to Co-Administered Antigen


Sunday, March 09 | 8:00AM - 11:00AM
Consequences of Cell Adhesion
This session is from Immune Response
Room: Shavano

Speaker 6 of 6
Matthew F. Krummel, University of California, San Francisco, USA
Short Talk: Functional Motor Proteins in T Cell Synapse Formation


Sunday, March 09 | 2:00PM - 4:30PM
Workshop 5: Harnessing Cell Biology During Vaccination and I
mmunotherapy
This session is from Immune Response
Room: Shavano

Speaker 1 of 14
* Jacques F. Banchereau, The Jackson Laboratory for Genomic Medicine, USA


Sunday, March 09 | 2:00PM - 4:30PM
Workshop 5: Harnessing Cell Biology During Vaccination and I
mmunotherapy
This session is from Immune Response
Room: Shavano

Speaker 2 of 14
* Ralph M. Steinman, Rockefeller University, USA


Sunday, March 09 | 2:00PM - 4:30PM
Workshop 5: Harnessing Cell Biology During Vaccination and I
mmunotherapy
This session is from Immune Response
Room: Shavano

Speaker 3 of 14
Wei Chen, University of Minnesota, USA
CpG ODN Activates Human Natural Killer Cells Predominantly via an Indirect Mechanism Through Plasmacytoid Dendritic Cells


Sunday, March 09 | 2:00PM - 4:30PM
Workshop 5: Harnessing Cell Biology During Vaccination and I
mmunotherapy
This session is from Immune Response
Room: Shavano

Speaker 4 of 14
Venky Ramakrishna, Medarex, Inc., USA
Targeting Antigens via CD206 Expressed on Human DCs Enables Cross-Presentation to CD8+ and CD4+ Effector T Cells


Sunday, March 09 | 2:00PM - 4:30PM
Workshop 5: Harnessing Cell Biology During Vaccination and I
mmunotherapy
This session is from Immune Response
Room: Shavano

Speaker 5 of 14
Clotilde Théry, Institut Curie, France
Role of MFG-E8/lactadherin in T cell Activation by Dendritic Cell-Derived Exosomes


Sunday, March 09 | 2:00PM - 4:30PM
Workshop 5: Harnessing Cell Biology During Vaccination and I
mmunotherapy
This session is from Immune Response
Room: Shavano

Speaker 6 of 14
Raphael Clynes, Xencor, Inc., USA
Role of FcgammaRII on Dendritic Cells in the Retention of Immune Complexes: A Possible Antigen-Recycling Pathway


Sunday, March 09 | 2:00PM - 4:30PM
Workshop 5: Harnessing Cell Biology During Vaccination and I
mmunotherapy
This session is from Immune Response
Room: Shavano

Speaker 7 of 14
Kate C. Agopsowicz, AltaRex Corporation, Canada
Opsonization with Specific Antibodies Enhances Dendritic cell Presentation of Apoptotic Tumor Cells and Induction of CTL


Sunday, March 09 | 2:00PM - 4:30PM
Workshop 5: Harnessing Cell Biology During Vaccination and I
mmunotherapy
This session is from Immune Response
Room: Shavano

Speaker 8 of 14
Holger Kanzler, Bill & Melinda Gates Foundation, USA
ISS-Antigen Conjugates Enhance MHC Class I Antigen Presentation


Sunday, March 09 | 2:00PM - 4:30PM
Workshop 5: Harnessing Cell Biology During Vaccination and I
mmunotherapy
This session is from Immune Response
Room: Shavano

Speaker 9 of 14
Hua E. Yu, Beckman Research Institute, City of Hope, USA
STAT3 Activity in Tumor Cells Negatively Regulates Dendritic Cell Activation and Maturation


Sunday, March 09 | 2:00PM - 4:30PM
Workshop 5: Harnessing Cell Biology During Vaccination and I
mmunotherapy
This session is from Immune Response
Room: Shavano

Speaker 10 of 14
† Shin-Ichiro Fujii, RIKEN IMS, Japan
Activation of Natural Killer Cells by alpha Galactosyl Ceramide Rapidly Induces the Full Maturation of Dendritic Cells in Mice and Thereby Acts as an Adjuvant for CD4 and CD8 T Cell Immunity to a Co-Administered Protein


Sunday, March 09 | 2:00PM - 4:30PM
Workshop 5: Harnessing Cell Biology During Vaccination and I
mmunotherapy
This session is from Immune Response
Room: Shavano

Speaker 11 of 14
Jan C. Dudda, Twincore, Germany
Targeting of CD8+ T Cells to Inflamed Skin by DC Immunization


Sunday, March 09 | 2:00PM - 4:30PM
Workshop 5: Harnessing Cell Biology During Vaccination and I
mmunotherapy
This session is from Immune Response
Room: Shavano

Speaker 12 of 14
John P. Vasilakos, Biothera, USA
Differential Activation of Human Innate Immune Cells using Small Molecule TLR Agonists


Sunday, March 09 | 2:00PM - 4:30PM
Workshop 5: Harnessing Cell Biology During Vaccination and I
mmunotherapy
This session is from Immune Response
Room: Shavano

Speaker 13 of 14
Gaetan Jego, Baylor Institute for Immunology Research, USA
Plasmacytoid Dendritic Cells Induce B and T Cell Memory Responses


Sunday, March 09 | 2:00PM - 4:30PM
Workshop 5: Harnessing Cell Biology During Vaccination and I
mmunotherapy
This session is from Immune Response
Room: Shavano

Speaker 14 of 14
† Beatrice Laupeze, Baylor Institute for Immunology Research, USA
Different Dendritic Cells can Induce Different Types of T Cell Responses


Sunday, March 09 | 5:00PM - 7:00PM
Cellular Mechanisms of Immune Evasion
This session is from Immune Response
Room: Shavano

Speaker 1 of 5
* Ralph M. Steinman, Rockefeller University, USA


Sunday, March 09 | 5:00PM - 7:00PM
Cellular Mechanisms of Immune Evasion
This session is from Immune Response
Room: Shavano

Speaker 2 of 5
Robert D. Schreiber, Washington University School of Medicine, USA
The Three E’s of Cancer Immunoediting


Sunday, March 09 | 5:00PM - 7:00PM
Cellular Mechanisms of Immune Evasion
This session is from Immune Response
Room: Shavano

Speaker 3 of 5
Tak W. Mak, Campbell Family Institute for Breast Cancer, Canada
Genetic Dissection of Lymphocyte Activation


Sunday, March 09 | 5:00PM - 7:00PM
Cellular Mechanisms of Immune Evasion
This session is from Immune Response
Room: Shavano

Speaker 4 of 5
Benoît J. Van den Eynde, University of Louvain, Belgium
A Novel Tumor Immune Escape Mechanism based on tryptophan Degradation by Indoleamine 2,3 Dioxygenase


Sunday, March 09 | 5:00PM - 7:00PM
Cellular Mechanisms of Immune Evasion
This session is from Immune Response
Room: Shavano

Speaker 5 of 5
Eric C. Bartee, Oregon Health & Science University, USA
Short Talk: Downregulation of Cell Surface Receptors by a Family of Human Ubiquitin Ligases Homologous to Viral Immune Evasion Proteins