Web Desc
Cell Biology of the Immune Response
joint with Dendritic Cells: Interfaces with Immunobiology and Medicine
Organizer(s): Ira Mellman, Richard Flavell and Ralph M. Steinman
Date: March 05 - 10, 2003
Location: Keystone Resort, Keystone, CO, USA
Supported by Keystone Symposia
Summary of Meeting:
The past 10-15 years have been marked by spectacular progress towards understanding the mechanisms of the immune response. At the same time, there have also been great strides made towards understanding the cell biological principles governing the behavior of all cells, including those of the immune system. Only recently, however, has attention been turned towards a systematic application of emerging principles in cell biology to considerations of the immune response. Such attention has already begun to provide important new concepts in areas as diverse as signal transduction, cell-cell interaction, lymphocyte development, antigen processing, and transcriptional regulation. The major goal of the proposed meeting is to further this emergent interface by bringing together investigators, postdoctoral fellows, and students from the broad range of the immunological community in a form with leading cell biologists representing a number of the most important and relevant areas of cell biology.
Discounted Abstract Deadline: November 5 2002
Discounted Registration Deadline: January 6 2003
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1 R13 AI053905-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, March 04 | 8:00AM - 11:00AM
Dendritic Cells and the Control of Immunity vs. Tolerance
This session is from Dendritic Cells
Room: Shavano/Torreys

Speaker 1 of 4
Yong-Jun Liu, Sanofi, USA
Human Epithelial Cells Trigger Dendritic Cell-Mediated Allergic Inflammation by Producing TSLP


Tuesday, March 04 | 8:00AM - 11:00AM
Dendritic Cells and the Control of Immunity vs. Tolerance
This session is from Dendritic Cells
Room: Shavano/Torreys

Speaker 2 of 4
Kayo Inaba, Kyoto University, Japan
Peripheral Tolerance via DCs in vivo


Tuesday, March 04 | 8:00AM - 11:00AM
Dendritic Cells and the Control of Immunity vs. Tolerance
This session is from Dendritic Cells
Room: Shavano/Torreys

Speaker 3 of 4
Maria Grazia Roncarolo, Stanford University School of Medicine, USA
Role of Regulatory T Cells in Immunological Tolerance


Tuesday, March 04 | 8:00AM - 11:00AM
Dendritic Cells and the Control of Immunity vs. Tolerance
This session is from Dendritic Cells
Room: Shavano/Torreys

Speaker 4 of 4
* Anne O'Garra, Francis Crick Institute, UK
Flexibility of Mouse Classical and Plasmacytoid-Derived Dendritic Cells in Directing Th1 and Th2 Cell Development: Dependency on Antigen Dose and Differential Toll-Like Receptor Ligation


Tuesday, March 04 | 2:00PM - 4:30PM
Workshop 1: Immunity and Tolerance to Tumors
This session is from Dendritic Cells
Room: Shavano/Torreys

Speaker 1 of 10
* Olivera J. Finn, University of Pittsburgh School of Medicine, USA


Tuesday, March 04 | 2:00PM - 4:30PM
Workshop 1: Immunity and Tolerance to Tumors
This session is from Dendritic Cells
Room: Shavano/Torreys

Speaker 2 of 10
Shu-Hsia Chen, Mount Sinai School of Medicine, USA
Regulation of Dendritic Cell Function by NK Cells: Mechanisms Underlying the Synergism between IL-12 and 4-1 BB Activation


Tuesday, March 04 | 2:00PM - 4:30PM
Workshop 1: Immunity and Tolerance to Tumors
This session is from Dendritic Cells
Room: Shavano/Torreys

Speaker 3 of 10
Michael D. Gunn, Duke University Medical Center, USA
Splenic Immature PDC Induce the Development of IL-10 Producing CD4+ T Regulatory Cells


Tuesday, March 04 | 2:00PM - 4:30PM
Workshop 1: Immunity and Tolerance to Tumors
This session is from Dendritic Cells
Room: Shavano/Torreys

Speaker 4 of 10
Michael R. Shurin, University of Pittsburgh, USA
Small Rho GTPases Regulate Dendropoiesis in Cancer


Tuesday, March 04 | 2:00PM - 4:30PM
Workshop 1: Immunity and Tolerance to Tumors
This session is from Dendritic Cells
Room: Shavano/Torreys

Speaker 5 of 10
Sally Ann Litherland, Florida Hospital Cancer Institute, USA
STAT5 Dysfunction in Autoimmune Myeloid Antigen Presenting Cell Activation and Differentiation


Tuesday, March 04 | 2:00PM - 4:30PM
Workshop 1: Immunity and Tolerance to Tumors
This session is from Dendritic Cells
Room: Shavano/Torreys

Speaker 6 of 10
Mariolina Salio, Weatherall Institute of Molecular Medicine, UK
Efficacy of Murine Myeloid and Plasmacytoid Dendritic Cells in Eliciting Adaptive Immune Responses


Tuesday, March 04 | 2:00PM - 4:30PM
Workshop 1: Immunity and Tolerance to Tumors
This session is from Dendritic Cells
Room: Shavano/Torreys

Speaker 7 of 10
Heather Zwickey, National College of Naturopathic Medicine, USA
DCs Presenting Self Antigens: Tolerance or Activation?


Tuesday, March 04 | 2:00PM - 4:30PM
Workshop 1: Immunity and Tolerance to Tumors
This session is from Dendritic Cells
Room: Shavano/Torreys

Speaker 8 of 10
Mohamad Mohty, INSERM U892 CHU de Nantes, France
Interferon-Alpha Skews Monocyte Differentiation into Toll-like Receptor 7 Expressing Dendritic Cells with Potent Functional Activities


Tuesday, March 04 | 2:00PM - 4:30PM
Workshop 1: Immunity and Tolerance to Tumors
This session is from Dendritic Cells
Room: Shavano/Torreys

Speaker 9 of 10
Hubert Eng, Virexx Inc., Canada
Complexation with Murine MAb-B43.13 Alters the Endocytic Trafficking of the Mucinous Tumor Antigen CA125 after Uptake by Human Dendritic Cells


Tuesday, March 04 | 2:00PM - 4:30PM
Workshop 1: Immunity and Tolerance to Tumors
This session is from Dendritic Cells
Room: Shavano/Torreys

Speaker 10 of 10
Alexandra M. Livingstone, University of Rochester Medical Center, USA
Helper-Dependent CD8+ T Cell Memory Requires CD40 Expression on the Immunizing Dendritic Cell, but Not on CD4+ or CD8+ T Cells.


Tuesday, March 04 | 5:00PM - 7:00PM
Dendritic Cell Maturation in vivo
This session is from Dendritic Cells
Room: Shavano/Torreys

Speaker 1 of 4
* Anne O'Garra, Francis Crick Institute, UK


Tuesday, March 04 | 5:00PM - 7:00PM
Dendritic Cell Maturation in vivo
This session is from Dendritic Cells
Room: Shavano/Torreys

Speaker 2 of 4
David F. Tough, Edward Jenner Institute for Vaccine Research, UK
Regulation of Immune Responses by Type I Interferon


Tuesday, March 04 | 5:00PM - 7:00PM
Dendritic Cell Maturation in vivo
This session is from Dendritic Cells
Room: Shavano/Torreys

Speaker 3 of 4
A. Karolina Palucka, The Jackson Laboratory for Genomic Medicine, USA
Dendritic Cells as Melanoma Vaccines


Tuesday, March 04 | 5:00PM - 7:00PM
Dendritic Cell Maturation in vivo
This session is from Dendritic Cells
Room: Shavano/Torreys

Speaker 4 of 4
Masaru Taniguchi, RIKEN RCAI, Japan
Regulatory Interaction between Valpha14 NKT Cells and Dendritic Cells


Wednesday, March 05 | 8:00AM - 11:00AM
Antigen Capture by DC in situ
This session is from Dendritic Cells
Room: Shavano/Torreys

Speaker 1 of 5
* Jacques F. Banchereau, The Jackson Laboratory for Genomic Medicine, USA


Wednesday, March 05 | 8:00AM - 11:00AM
Antigen Capture by DC in situ
This session is from Dendritic Cells
Room: Shavano/Torreys

Speaker 2 of 5
Michel C. Nussenzweig, HHMI/Rockefeller University, USA
Targeting Antigens to Lymphoid Tissue DCs


Wednesday, March 05 | 8:00AM - 11:00AM
Antigen Capture by DC in situ
This session is from Dendritic Cells
Room: Shavano/Torreys

Speaker 3 of 5
Marc K. Jenkins, University of Minnesota Medical School, USA
In Vivo Analysis of Antigen-Presentation to CD4 T Cells


Wednesday, March 05 | 8:00AM - 11:00AM
Antigen Capture by DC in situ
This session is from Dendritic Cells
Room: Shavano/Torreys

Speaker 4 of 5
Giorgio Trinchieri, NCI, National Institutes of Health, USA
Physiology of Mouse Interferon Producing Cells


Wednesday, March 05 | 8:00AM - 11:00AM
Antigen Capture by DC in situ
This session is from Dendritic Cells
Room: Shavano/Torreys

Speaker 5 of 5
Akiko Iwasaki, HHMI/Yale University School of Medicine, USA
Short Talk: Primary Role of Vaginal Dendritic Cells in Th1 Induction during Genital Herpes Simplex Virus-2 Infection


Wednesday, March 05 | 2:00PM - 4:30PM
Workshop 2: DC Capture of Antigens and Pathogens
This session is from Dendritic Cells
Room: Shavano/Torreys

Speaker 1 of 12
* Alan Sher, NIAID, National Institutes of Health, USA


Wednesday, March 05 | 2:00PM - 4:30PM
Workshop 2: DC Capture of Antigens and Pathogens
This session is from Dendritic Cells
Room: Shavano/Torreys

Speaker 2 of 12
* Paola Ricciardi-Castagnoli, Toscana Life Science Foundation, Italy


Wednesday, March 05 | 2:00PM - 4:30PM
Workshop 2: DC Capture of Antigens and Pathogens
This session is from Dendritic Cells
Room: Shavano/Torreys

Speaker 3 of 12
Li-Yun Coty Huang, U.S. Food and Drug Administration, USA
Brucella abortus Activates Dendritic Cells and Splenocytes to Secrete IL-12p40 and TNFalpha via Different Toll-Like Receptors


Wednesday, March 05 | 2:00PM - 4:30PM
Workshop 2: DC Capture of Antigens and Pathogens
This session is from Dendritic Cells
Room: Shavano/Torreys

Speaker 4 of 12
Marina N. Fleeton, National Institutes of Health, USA
CD11blo/CD8alpha- Peyer’s Patch Dendritic Cells Process Epithelial Cell-Associated Viral Antigens following Infection with Reovirus, Type 1 Lang


Wednesday, March 05 | 2:00PM - 4:30PM
Workshop 2: DC Capture of Antigens and Pathogens
This session is from Dendritic Cells
Room: Shavano/Torreys

Speaker 5 of 12
Amy C. Herring, University of Michigan, USA
The Role of Pulmonary Dendritic Cells in the Developing T1 Response to Cryptococcus neoformans Infection


Wednesday, March 05 | 2:00PM - 4:30PM
Workshop 2: DC Capture of Antigens and Pathogens
This session is from Dendritic Cells
Room: Shavano/Torreys

Speaker 6 of 12
W. L. William Chang, University of California, Davis, USA
Alteration of Dendritic Cell Maturation and Functions by Cytomegalovirus-Encoded Interleukin-10


Wednesday, March 05 | 2:00PM - 4:30PM
Workshop 2: DC Capture of Antigens and Pathogens
This session is from Dendritic Cells
Room: Shavano/Torreys

Speaker 7 of 12
Christopher M. Smith, Walter and Eliza Hall Institute of Medical Research, Australia
Conventional CD8a+ Dendritic Cells Prime CTL Immunity to Cutaneous Herpes Simplex Virus-1 Infection


Wednesday, March 05 | 2:00PM - 4:30PM
Workshop 2: DC Capture of Antigens and Pathogens
This session is from Dendritic Cells
Room: Shavano/Torreys

Speaker 8 of 12
Gabriele Pollara, University College London, UK
Dendritic Cell Innate Responses to HSV Infection


Wednesday, March 05 | 2:00PM - 4:30PM
Workshop 2: DC Capture of Antigens and Pathogens
This session is from Dendritic Cells
Room: Shavano/Torreys

Speaker 9 of 12
Kevin L. Legge, University of Iowa Carver College of Medicine, USA
Respiratory Dendritic Cell Trafficking to the Regional Lymph Nodes is Limited to the Early Stage of Experimental Influenza Infection


Wednesday, March 05 | 2:00PM - 4:30PM
Workshop 2: DC Capture of Antigens and Pathogens
This session is from Dendritic Cells
Room: Shavano/Torreys

Speaker 10 of 12
Maria Rescigno, Humanitas University, Italy
Bacteria Impede the Migratory Clearance and the Differentiation of Monocytes into Dendritic Cells to Lymph Nodes and Thereby Limit the Development of Adaptive Immune Responses


Wednesday, March 05 | 2:00PM - 4:30PM
Workshop 2: DC Capture of Antigens and Pathogens
This session is from Dendritic Cells
Room: Shavano/Torreys

Speaker 11 of 12
Leopoldo Flores-Romo, El Centro de Investigación y de Estudios Avanzados del IPN, Mexico
Cutaneous Langerhans Dendritic Cells in a Murine Model of Leprosy: in vivo Analysis


Wednesday, March 05 | 2:00PM - 4:30PM
Workshop 2: DC Capture of Antigens and Pathogens
This session is from Dendritic Cells
Room: Shavano/Torreys

Speaker 12 of 12
Anne Hosmalin, INSERM U1016 Institut Cochin, Université Paris Descartes, France
Processing of an HIV-1 Immunodominant Restricted Epitope by the Cytosolic Protease TPPII


Wednesday, March 05 | 3:00PM - 7:00PM
Registration
Room: Shavano Peak Office


Wednesday, March 05 | 5:00PM - 7:00PM
Exogenous Pathway and Cross-Presentation
This session is from Dendritic Cells
Room: Shavano/Torreys

Speaker 1 of 9
* Jacques F. Banchereau, The Jackson Laboratory for Genomic Medicine, USA


Wednesday, March 05 | 5:00PM - 7:00PM
Exogenous Pathway and Cross-Presentation
This session is from Dendritic Cells
Room: Shavano/Torreys

Speaker 2 of 9
Michael J. Bevan, HHMI/University of Washington, USA
Maintaining memory


Wednesday, March 05 | 5:00PM - 7:00PM
Exogenous Pathway and Cross-Presentation
This session is from Dendritic Cells
Room: Shavano/Torreys

Speaker 3 of 9
Sebastian Amigorena, Institut Curie, France
Exogenous Pathway via Fc Receptors


Wednesday, March 05 | 5:00PM - 7:00PM
Exogenous Pathway and Cross-Presentation
This session is from Dendritic Cells
Room: Shavano/Torreys

Speaker 4 of 9
Philippe D. Pierre, Centre d'Immunologie Marseille-Luminy, CIML, France
Aggregation in Maturing DCs, A Mean to Segregate Self Antigens from the Proteasome


Wednesday, March 05 | 5:00PM - 7:00PM
Exogenous Pathway and Cross-Presentation
This session is from Dendritic Cells
Room: Shavano/Torreys

Speaker 5 of 9
Carl G. Figdor, Radboud University Medical Center, Netherlands
Short Talk: The C-Type Lectin DC-SIGN (CD209) is an Antigen Uptake Receptor for Candida albicans on Dendritic Cells


Wednesday, March 05 | 5:00PM - 7:00PM
Exogenous Pathway and Cross-Presentation
This session is from Dendritic Cells
Room: Shavano/Torreys

Speaker 6 of 9
Stefan Freigang, University Hospital Zurich, Switzerland
Short Talk: Endogenous Neosynthesis Versus Cross-Presentation of Polioviral Antigen for CTL Priming


Wednesday, March 05 | 5:00PM - 7:00PM
Exogenous Pathway and Cross-Presentation
This session is from Dendritic Cells
Room: Shavano/Torreys

Speaker 7 of 9
Maria Carmen Ramirez Mazcunyan, Fox Chase Cancer Center, USA
Short Talk: Macrophages and Dendritic Cells Use the Cytosolic Pathway to Rapidly Cross-Present Antigen from Live, Vaccinia-Infected Cells


Wednesday, March 05 | 5:00PM - 7:00PM
Exogenous Pathway and Cross-Presentation
This session is from Dendritic Cells
Room: Shavano/Torreys

Speaker 8 of 9
Nicolas Glaichenhaus, Centre National de la Recherche Scientifique, France
Short Talk: CD11b+ Dendritic Cells are Responsible for the Activation of CD4+ T Cells in Mice Infected with the Intracellular Parasite Leishmania Major


Wednesday, March 05 | 5:00PM - 7:00PM
Exogenous Pathway and Cross-Presentation
This session is from Dendritic Cells
Room: Shavano/Torreys

Speaker 9 of 9
Lélia Delamarre, Genentech, Inc., USA
Short Talk: Presentation of Exogenous Antigens on MHC I and MHC II is Differentially Regulated during Dendritic Cell Maturation


Wednesday, March 05 | 6:45PM - 7:45PM
Welcome
Room: Shavano Peak Foyer


Wednesday, March 05 | 7:45PM - 8:00PM
Orientation
Room: Shavano/Torreys


Thursday, March 06 | 7:00AM - 8:00AM
Breakfast
Room: Crestone/Red Cloud


Thursday, March 06 | 8:00AM - 11:00AM
Transmission of Signals to the Nucleus: General Principles
(Joint)

Room: Shavano/Torreys

Speaker 1 of 6
Joseph Schlessinger, Yale University School of Medicine, USA
Tyrosine Kinases

Thursday, March 06 | 8:00AM - 11:00AM
Transmission of Signals to the Nucleus: General Principles
(Joint)

Room: Shavano/Torreys

Speaker 2 of 6
Amer A. Beg, Moffitt Cancer Center, USA
NF-kappaB Signaling in Dendritic Cells

Thursday, March 06 | 8:00AM - 11:00AM
Transmission of Signals to the Nucleus: General Principles
(Joint)

Room: Shavano/Torreys

Speaker 3 of 6
* Richard A. Flavell, HHMI/Yale University School of Medicine, USA
Signal-Mediated Control of Transcription

Thursday, March 06 | 8:00AM - 11:00AM
Transmission of Signals to the Nucleus: General Principles
(Joint)

Room: Shavano/Torreys

Speaker 4 of 6
Gioacchino Natoli, Humanitas University, Italy
Close-Ups of NF-kappa B Recruitment to Target Genes in DCs

Thursday, March 06 | 8:00AM - 11:00AM
Transmission of Signals to the Nucleus: General Principles
(Joint)

Room: Shavano/Torreys

Speaker 5 of 6
Takashi Kobayashi, University of Pennsylvania, USA
Short Talk: TRAF6 Regulates Dendritic Cell Development and Function

Thursday, March 06 | 8:00AM - 11:00AM
Transmission of Signals to the Nucleus: General Principles
(Joint)

Room: Shavano/Torreys

Speaker 6 of 6
Salome Landmann, Centre Medical Universitaire, Switzerland
Short Talk: The Role of the Class II Transactivator (CIITA) in Dendritic Cells

Thursday, March 06 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Thursday, March 06 | 11:00AM - 1:00PM
Poster Setup
Room: Longs Peak/Grays Peak


Thursday, March 06 | 1:00PM - 10:00PM
Poster Viewing
Room: Longs Peak/Grays Peak


Thursday, March 06 | 2:00PM - 4:30PM
Workshop 3: Rafts: Fact or Fiction? (Joint)
Room: Shavano/Torreys

Speaker 1 of 8
* † Derek Toomre, Yale University School of Medicine, USA

Thursday, March 06 | 2:00PM - 4:30PM
Workshop 3: Rafts: Fact or Fiction? (Joint)
Room: Shavano/Torreys

Speaker 2 of 8
† Christian O. Meyer zum Buschenfelde, Yale University, USA
Recruitment of CD28 and CD86 to Lipid Rafts during DC-T Cell Interaction Results in Efficient T Cell Priming

Thursday, March 06 | 2:00PM - 4:30PM
Workshop 3: Rafts: Fact or Fiction? (Joint)
Room: Shavano/Torreys

Speaker 3 of 8
Jeoung-Sook Shin, University of California, San Francisco, USA
Mast Cell Endo/Exocytosis of Particulate Allergens

Thursday, March 06 | 2:00PM - 4:30PM
Workshop 3: Rafts: Fact or Fiction? (Joint)
Room: Shavano/Torreys

Speaker 4 of 8
Neil Poloso, Allergan Inc., USA
Kinetics of MHC Class II Complex Association with Lipid Rafts

Thursday, March 06 | 2:00PM - 4:30PM
Workshop 3: Rafts: Fact or Fiction? (Joint)
Room: Shavano/Torreys

Speaker 5 of 8
Lee Leserman, Centre d'Immunologie de Marseille-Luminy, France
MHC Class II/Peptide Complexes in Lipid Microdomains at The Dendritic Cell Surface Initiate the TH1 CD4 T Cell Phenotype

Thursday, March 06 | 2:00PM - 4:30PM
Workshop 3: Rafts: Fact or Fiction? (Joint)
Room: Shavano/Torreys

Speaker 6 of 8
Richard M. Siegel, NIAMS, National Institutes of Health, USA
Lipid Microdomains and Receptor Clustering in Fas/CD95 Signaling

Thursday, March 06 | 2:00PM - 4:30PM
Workshop 3: Rafts: Fact or Fiction? (Joint)
Room: Shavano/Torreys

Speaker 7 of 8
Alessandra Cambi, Max Planck Institute for Biophysical Chemistry, Germany
Distribution of LFA-1 and DC-SIGN in Microdomains on DC by High Resolution Microscopy: Consequences for Cell-Adhesion and Ligand Binding

Thursday, March 06 | 2:00PM - 4:30PM
Workshop 3: Rafts: Fact or Fiction? (Joint)
Room: Shavano/Torreys

Speaker 8 of 8
Juli J. Unternaehrer, Children's Hospital Boston, USA
Surface MHC-II I-E Associates with I-A in Dendritic Cells but Not in B Cells

Thursday, March 06 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Longs Peak Foyer


Thursday, March 06 | 5:00PM - 7:00PM
Signal Transduction and Antigen Presentation (Joint)
Room: Shavano/Torreys

Speaker 1 of 5
* Richard A. Flavell, HHMI/Yale University School of Medicine, USA

Thursday, March 06 | 5:00PM - 7:00PM
Signal Transduction and Antigen Presentation (Joint)
Room: Shavano/Torreys

Speaker 2 of 5
Tsuneyasu Kaisho, RIKEN Research Center for Allergy and Immunology, Japan
Pleiotropic Function of Toll-Like Receptors on Dendritic Cells

Thursday, March 06 | 5:00PM - 7:00PM
Signal Transduction and Antigen Presentation (Joint)
Room: Shavano/Torreys

Speaker 3 of 5
Alan Aderem, Center for Infectious Disease Research, USA
Macrophage Phagocytosis: from Genes to Function

Thursday, March 06 | 5:00PM - 7:00PM
Signal Transduction and Antigen Presentation (Joint)
Room: Shavano/Torreys

Speaker 4 of 5
Ruslan Medzhitov, HHMI/Yale University School of Medicine, USA
Toll Pathway of Host Defense

Thursday, March 06 | 5:00PM - 7:00PM
Signal Transduction and Antigen Presentation (Joint)
Room: Shavano/Torreys

Speaker 5 of 5
Caetano Reis e Sousa, Francis Crick Institute, UK
Short Talk: Non-Plasmacytoid Dendritic Cells Act as Interferon-Producing Cells in Response to Cytosolic Double-Stranded RNA

Thursday, March 06 | 7:00PM - 8:00PM
Social Hour
Room: Longs Peak/Grays Peak


Thursday, March 06 | 8:00PM - 10:00PM
Poster Session 3: Signal Transduction
Room: Longs Peak/Grays Peak


Friday, March 07 | 7:00AM - 8:00AM
Breakfast
Room: Crestone/Red Cloud


Friday, March 07 | 8:00AM - 11:00AM
Endocytosis and Lysosomal Transport (Joint)
Room: Shavano/Torreys

Speaker 1 of 7
* Ira Mellman, Genentech, Inc., USA

Friday, March 07 | 8:00AM - 11:00AM
Endocytosis and Lysosomal Transport (Joint)
Room: Shavano/Torreys

Speaker 2 of 7
Scott D. Emr, Cornell University, USA
Receptor Down-Regulation and Protein Sorting at the Multivesicular Body

Friday, March 07 | 8:00AM - 11:00AM
Endocytosis and Lysosomal Transport (Joint)
Room: Shavano/Torreys

Speaker 3 of 7
Margaret S. Robinson, University of Cambridge, UK
Coat proteins and sorting

Friday, March 07 | 8:00AM - 11:00AM
Endocytosis and Lysosomal Transport (Joint)
Room: Shavano/Torreys

Speaker 4 of 7
Suzanne R. Pfeffer, Stanford University, USA
Rab GTPases in Receptor Trafficking

Friday, March 07 | 8:00AM - 11:00AM
Endocytosis and Lysosomal Transport (Joint)
Room: Shavano/Torreys

Speaker 5 of 7
Giorgio Scita, IFOM Foundation at Campus IFOM-IEO, Italy
Integration of Signals Leading to Actin Remodeling and Endocytosis

Friday, March 07 | 8:00AM - 11:00AM
Endocytosis and Lysosomal Transport (Joint)
Room: Shavano/Torreys

Speaker 6 of 7
Angela Stoddart, University of California, San Francisco, USA
Short Talk: Deciphering the Roles of Lipid Rafts and Clathrin in BCR Internalization

Friday, March 07 | 8:00AM - 11:00AM
Endocytosis and Lysosomal Transport (Joint)
Room: Shavano/Torreys

Speaker 7 of 7
Haoran Zhao, Genentech, USA
Short Talk: TRAC-1, A Novel Lymphocyte-Specific E3 Ubiquitin Ligase, Regulates T Cell Activation Downstream of TCR Engagement

Friday, March 07 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Friday, March 07 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Longs Peak Foyer


Friday, March 07 | 5:00PM - 7:00PM
Mechanisms of Proteolysis in the Cytosol (Joint)
Room: Shavano/Torreys

Speaker 1 of 4
* Ira Mellman, Genentech, Inc., USA

Friday, March 07 | 5:00PM - 7:00PM
Mechanisms of Proteolysis in the Cytosol (Joint)
Room: Shavano/Torreys

Speaker 2 of 4
Wolfgang P. Baumeister, Max Planck Institute of Biochemistry, Germany
Electron Tomography: Visualizing Macromolecular Complexes in Intact Cells

Friday, March 07 | 5:00PM - 7:00PM
Mechanisms of Proteolysis in the Cytosol (Joint)
Room: Shavano/Torreys

Speaker 3 of 4
Jack R. Bennink, NIAID, National Institutes of Health, USA
The Origin of Antigenic Peptides and Proteasomal Degradation of Newly Synthesized Proteins

Friday, March 07 | 5:00PM - 7:00PM
Mechanisms of Proteolysis in the Cytosol (Joint)
Room: Shavano/Torreys

Speaker 4 of 4
Alfred L. Goldberg, Harvard Medical School, USA
Peptidases that Function after the Proteasome and Regulate Antigen Presentation

Friday, March 07 | 7:00PM - 8:00PM
Social Hour
Room: Grays Peak


Friday, March 07 | 8:00PM - 11:00PM
Entertainment
Room: Torrey's Peak


Saturday, March 08 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud


Saturday, March 08 | 8:00AM - 11:00AM
Functional Specializations of the Endocytic Pathway
Room: Shavano

Speaker 1 of 7
* Ralph M. Steinman, Rockefeller University, USA

Saturday, March 08 | 8:00AM - 11:00AM
Functional Specializations of the Endocytic Pathway
Room: Shavano

Speaker 2 of 7
Christopher V. Nicchitta, Duke University School of Medicine, USA
Heat Shock Proteins and Antigen Presentation

Saturday, March 08 | 8:00AM - 11:00AM
Functional Specializations of the Endocytic Pathway
Room: Shavano

Speaker 3 of 7
Sergio Grinstein, Hospital for Sick Children, Canada
Role of Phosphoinositides in Phagosome Formation and in Bacterial Invasion

Saturday, March 08 | 8:00AM - 11:00AM
Functional Specializations of the Endocytic Pathway
Room: Shavano

Speaker 4 of 7
Dorothee Schmid, Rockefeller University, USA
Short Talk: A Novel Pathway for Endogenous MHC Class II Presentation of a Nuclear Viral Antigen that Involves Autophagy

Saturday, March 08 | 8:00AM - 11:00AM
Functional Specializations of the Endocytic Pathway
Room: Shavano

Speaker 5 of 7
Dan R. Littman, HHMI/New York University School of Medicine, USA
DC-SIGN and Transmission of HIV-1 Following Endocytosis

Saturday, March 08 | 8:00AM - 11:00AM
Functional Specializations of the Endocytic Pathway
Room: Shavano

Speaker 6 of 7
Eduardo Sergio Trombetta, Yale University, USA
Regulation of Lysosomal Function in Dendritic Cells

Saturday, March 08 | 8:00AM - 11:00AM
Functional Specializations of the Endocytic Pathway
Room: Shavano

Speaker 7 of 7
Thomas J. Hope, Northwestern University, USA
Short Talk: Enhancement of HIV Infection by Dendritic Cells: Transfer of HIV to Target Cells Through an Infectious Synapse

Saturday, March 08 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Saturday, March 08 | 11:00AM - 1:00PM
Poster Setup
Room: Torreys Peak


Saturday, March 08 | 1:00PM - 10:00PM
Poster Viewing
Room: Torreys Peak


Saturday, March 08 | 2:00PM - 4:30PM
Workshop 4: Mechanisms of Antigen Processing and Presentatio
n
Room: Shavano

Speaker 1 of 12
* Hans-Georg Rammensee, University of Tübingen, Germany

Saturday, March 08 | 2:00PM - 4:30PM
Workshop 4: Mechanisms of Antigen Processing and Presentatio
n
Room: Shavano

Speaker 2 of 12
* Ira Mellman, Genentech, Inc., USA

Saturday, March 08 | 2:00PM - 4:30PM
Workshop 4: Mechanisms of Antigen Processing and Presentatio
n
Room: Shavano

Speaker 3 of 12
Deborah Palliser, Takeda, USA
Delineation of the Pathway Taken by a Heat Shock Fusion Protein to Gain Access to the MHC Class I Processing Pathway in Dendritic Cells

Saturday, March 08 | 2:00PM - 4:30PM
Workshop 4: Mechanisms of Antigen Processing and Presentatio
n
Room: Shavano

Speaker 4 of 12
Dorian B. McGavern, NINDS, National Institutes of Health, USA
Visualizing Antigen-Specific T Cells Involved in Immunopathogenesis

Saturday, March 08 | 2:00PM - 4:30PM
Workshop 4: Mechanisms of Antigen Processing and Presentatio
n
Room: Shavano

Speaker 5 of 12
Scott A. Wetzel, University of Montana, USA
Peptide Specific Transfer of MHC From APC to T cells Through the Immunological Synapse

Saturday, March 08 | 2:00PM - 4:30PM
Workshop 4: Mechanisms of Antigen Processing and Presentatio
n
Room: Shavano

Speaker 6 of 12
Heiichiro Udono, Nagasaki University, Japan
Two Distinct Pathways Mediated by PA28 and hsp90 in Antigen Processing that is Linked with MHC I Polymorphism

Saturday, March 08 | 2:00PM - 4:30PM
Workshop 4: Mechanisms of Antigen Processing and Presentatio
n
Room: Shavano

Speaker 7 of 12
Michael F. Princiotta, Advaxis, Inc, USA
Quantitating Viral Protein Synthesis, Degradation and Endogenous Antigen Processing

Saturday, March 08 | 2:00PM - 4:30PM
Workshop 4: Mechanisms of Antigen Processing and Presentatio
n
Room: Shavano

Speaker 8 of 12
Ona E. Bloom, Yale University School of Medicine, USA
Spinophilin, a Neuronal Protein at the Immunological Synapse

Saturday, March 08 | 2:00PM - 4:30PM
Workshop 4: Mechanisms of Antigen Processing and Presentatio
n
Room: Shavano

Speaker 9 of 12
Julie Magarian Blander, Weill Cornell Medicine, Cornell University, USA
Signals from Toll-Like Receptors Control Phagolysosomal Fusion

Saturday, March 08 | 2:00PM - 4:30PM
Workshop 4: Mechanisms of Antigen Processing and Presentatio
n
Room: Shavano

Speaker 10 of 12
Babak Javid, University of California San Francisco, USA
Efficient Cross-Presentation of Mycobacterial Heat Shock Protein / Antigen Complexes by Human Dendritic Cells

Saturday, March 08 | 2:00PM - 4:30PM
Workshop 4: Mechanisms of Antigen Processing and Presentatio
n
Room: Shavano

Speaker 11 of 12
Wilfred A. Jefferies, University of British Columbia, Canada
The Cytoplasmic Domain of MHC Class I Proteins Controls Intracellular Trafficking and Cross-Presentation

Saturday, March 08 | 2:00PM - 4:30PM
Workshop 4: Mechanisms of Antigen Processing and Presentatio
n
Room: Shavano

Speaker 12 of 12
Marco A. Purbhoo, Howard Hughes Medical Institute, USA
Differential Dynamics of CD8, TCR, and MHC at the Immunological Synapse

Saturday, March 08 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Shavano Peak Foyer


Saturday, March 08 | 5:00PM - 7:00PM
Cell Migration
Room: Shavano

Speaker 1 of 5
* Ralph M. Steinman, Rockefeller University, USA

Saturday, March 08 | 5:00PM - 7:00PM
Cell Migration
Room: Shavano

Speaker 2 of 5
Ulrich H. Von Andrian, Harvard Medical School, USA
T Cell Traffic and Interactions With DC in Lymphoid Tissues

Saturday, March 08 | 5:00PM - 7:00PM
Cell Migration
Room: Shavano

Speaker 3 of 5
Gwendalyn J. Randolph, Washington University, USA
Dendritic Cell Migration from the Periphery to Lymph Nodes and Spleen: Insights from Analysis during Atherosclerotic Disease

Saturday, March 08 | 5:00PM - 7:00PM
Cell Migration
Room: Shavano

Speaker 4 of 5
Tatyana Svitkina, University of Pennsylvania, USA
Actin Machinery at the Leading Edge of Migrating Cells

Saturday, March 08 | 5:00PM - 7:00PM
Cell Migration
Room: Shavano

Speaker 5 of 5
Smita Nair, Duke University School of Medicine, USA
Short Talk: Injection of Immature Dendritic Cells into Adjuvant Treated Skin Obviates the Need for ex vivo Maturation.

Saturday, March 08 | 7:00PM - 8:00PM
Social Hour
Room: Torreys Peak


Saturday, March 08 | 8:00PM - 10:00PM
Poster Session 4: Antigen Presentation and Dendritic Cell Mi
gration
Room: Torreys Peak


Sunday, March 09 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud


Sunday, March 09 | 8:00AM - 11:00AM
Consequences of Cell Adhesion
Room: Shavano

Speaker 1 of 6
* Ralph M. Steinman, Rockefeller University, USA

Sunday, March 09 | 8:00AM - 11:00AM
Consequences of Cell Adhesion
Room: Shavano

Speaker 2 of 6
Gillian Griffiths, Cambridge Institute for Medical Research, UK
The Genetics of Cytotoxic T Cell Polarization and Secretion

Sunday, March 09 | 8:00AM - 11:00AM
Consequences of Cell Adhesion
Room: Shavano

Speaker 3 of 6
Michael O. Hengartner, University of Zürich, Switzerland
C. elegans CED Proteins and Engulfment of Apoptotic Cells

Sunday, March 09 | 8:00AM - 11:00AM
Consequences of Cell Adhesion
Room: Shavano

Speaker 4 of 6
Josef M. Penninger, Institute of Molecular Biotechnology GmbH, Austria
Dendritic Cells, Autoimmunity and Infectious Stimuli

Sunday, March 09 | 8:00AM - 11:00AM
Consequences of Cell Adhesion
Room: Shavano

Speaker 5 of 6
Thomas M. Moran, Mount Sinai School of Medicine, USA
Short Talk: Influenza Virus Induced Dendritic Cell Maturation In Vivo Correlates with Induction of Immune Responses to Co-Administered Antigen

Sunday, March 09 | 8:00AM - 11:00AM
Consequences of Cell Adhesion
Room: Shavano

Speaker 6 of 6
Matthew F. Krummel, University of California, San Francisco, USA
Short Talk: Functional Motor Proteins in T Cell Synapse Formation

Sunday, March 09 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Sunday, March 09 | 2:00PM - 4:30PM
Workshop 5: Harnessing Cell Biology During Vaccination and I
mmunotherapy
Room: Shavano

Speaker 1 of 14
* Jacques F. Banchereau, The Jackson Laboratory for Genomic Medicine, USA

Sunday, March 09 | 2:00PM - 4:30PM
Workshop 5: Harnessing Cell Biology During Vaccination and I
mmunotherapy
Room: Shavano

Speaker 2 of 14
* Ralph M. Steinman, Rockefeller University, USA

Sunday, March 09 | 2:00PM - 4:30PM
Workshop 5: Harnessing Cell Biology During Vaccination and I
mmunotherapy
Room: Shavano

Speaker 3 of 14
Wei Chen, University of Minnesota, USA
CpG ODN Activates Human Natural Killer Cells Predominantly via an Indirect Mechanism Through Plasmacytoid Dendritic Cells

Sunday, March 09 | 2:00PM - 4:30PM
Workshop 5: Harnessing Cell Biology During Vaccination and I
mmunotherapy
Room: Shavano

Speaker 4 of 14
Venky Ramakrishna, Medarex, Inc., USA
Targeting Antigens via CD206 Expressed on Human DCs Enables Cross-Presentation to CD8+ and CD4+ Effector T Cells

Sunday, March 09 | 2:00PM - 4:30PM
Workshop 5: Harnessing Cell Biology During Vaccination and I
mmunotherapy
Room: Shavano

Speaker 5 of 14
Clotilde Théry, Institut Curie, France
Role of MFG-E8/lactadherin in T cell Activation by Dendritic Cell-Derived Exosomes

Sunday, March 09 | 2:00PM - 4:30PM
Workshop 5: Harnessing Cell Biology During Vaccination and I
mmunotherapy
Room: Shavano

Speaker 6 of 14
Raphael Clynes, Xencor, Inc., USA
Role of FcgammaRII on Dendritic Cells in the Retention of Immune Complexes: A Possible Antigen-Recycling Pathway

Sunday, March 09 | 2:00PM - 4:30PM
Workshop 5: Harnessing Cell Biology During Vaccination and I
mmunotherapy
Room: Shavano

Speaker 7 of 14
Kate C. Agopsowicz, AltaRex Corporation, Canada
Opsonization with Specific Antibodies Enhances Dendritic cell Presentation of Apoptotic Tumor Cells and Induction of CTL

Sunday, March 09 | 2:00PM - 4:30PM
Workshop 5: Harnessing Cell Biology During Vaccination and I
mmunotherapy
Room: Shavano

Speaker 8 of 14
Holger Kanzler, Bill & Melinda Gates Foundation, USA
ISS-Antigen Conjugates Enhance MHC Class I Antigen Presentation

Sunday, March 09 | 2:00PM - 4:30PM
Workshop 5: Harnessing Cell Biology During Vaccination and I
mmunotherapy
Room: Shavano

Speaker 9 of 14
Hua E. Yu, Beckman Research Institute, City of Hope, USA
STAT3 Activity in Tumor Cells Negatively Regulates Dendritic Cell Activation and Maturation

Sunday, March 09 | 2:00PM - 4:30PM
Workshop 5: Harnessing Cell Biology During Vaccination and I
mmunotherapy
Room: Shavano

Speaker 10 of 14
† Shin-Ichiro Fujii, RIKEN IMS, Japan
Activation of Natural Killer Cells by alpha Galactosyl Ceramide Rapidly Induces the Full Maturation of Dendritic Cells in Mice and Thereby Acts as an Adjuvant for CD4 and CD8 T Cell Immunity to a Co-Administered Protein

Sunday, March 09 | 2:00PM - 4:30PM
Workshop 5: Harnessing Cell Biology During Vaccination and I
mmunotherapy
Room: Shavano

Speaker 11 of 14
Jan C. Dudda, Twincore, Germany
Targeting of CD8+ T Cells to Inflamed Skin by DC Immunization

Sunday, March 09 | 2:00PM - 4:30PM
Workshop 5: Harnessing Cell Biology During Vaccination and I
mmunotherapy
Room: Shavano

Speaker 12 of 14
John P. Vasilakos, Biothera, USA
Differential Activation of Human Innate Immune Cells using Small Molecule TLR Agonists

Sunday, March 09 | 2:00PM - 4:30PM
Workshop 5: Harnessing Cell Biology During Vaccination and I
mmunotherapy
Room: Shavano

Speaker 13 of 14
Gaetan Jego, Baylor Institute for Immunology Research, USA
Plasmacytoid Dendritic Cells Induce B and T Cell Memory Responses

Sunday, March 09 | 2:00PM - 4:30PM
Workshop 5: Harnessing Cell Biology During Vaccination and I
mmunotherapy
Room: Shavano

Speaker 14 of 14
† Beatrice Laupeze, Baylor Institute for Immunology Research, USA
Different Dendritic Cells can Induce Different Types of T Cell Responses

Sunday, March 09 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Shavano Peak Foyer


Sunday, March 09 | 5:00PM - 7:00PM
Cellular Mechanisms of Immune Evasion
Room: Shavano

Speaker 1 of 5
* Ralph M. Steinman, Rockefeller University, USA

Sunday, March 09 | 5:00PM - 7:00PM
Cellular Mechanisms of Immune Evasion
Room: Shavano

Speaker 2 of 5
Robert D. Schreiber, Washington University School of Medicine, USA
The Three E’s of Cancer Immunoediting

Sunday, March 09 | 5:00PM - 7:00PM
Cellular Mechanisms of Immune Evasion
Room: Shavano

Speaker 3 of 5
Tak W. Mak, Campbell Family Institute for Breast Cancer, Canada
Genetic Dissection of Lymphocyte Activation

Sunday, March 09 | 5:00PM - 7:00PM
Cellular Mechanisms of Immune Evasion
Room: Shavano

Speaker 4 of 5
Benoît J. Van den Eynde, University of Louvain, Belgium
A Novel Tumor Immune Escape Mechanism based on tryptophan Degradation by Indoleamine 2,3 Dioxygenase

Sunday, March 09 | 5:00PM - 7:00PM
Cellular Mechanisms of Immune Evasion
Room: Shavano

Speaker 5 of 5
Eric C. Bartee, Oregon Health & Science University, USA
Short Talk: Downregulation of Cell Surface Receptors by a Family of Human Ubiquitin Ligases Homologous to Viral Immune Evasion Proteins

Sunday, March 09 | 7:00PM - 8:00PM
Social Hour
Room: Torreys Peak


Sunday, March 09 | 8:00PM - 11:00PM
Cash Bar
Room: Torreys Peak


Monday, March 10 | 10:26AM - 10:26AM
Departure


*Session Chair.