Web Desc
The Regulation of Mucosal Inflammation
joint with Hygiene, Allergy and Asthma
Organizer(s): Warren Strober and Fiona Powrie
Date: April 01 - 06, 2003
Location: Keystone Resort, Keystone, CO, USA
Supported by Keystone Symposia
For important information on the coronavirus, please click here
Summary of Meeting:
This Keystone Symposia will focus on the regulation of mucosal inflammation and will consider mechanisms of inflammation relative to all mucosal surfaces. It will be held in conjunction with a second symposium entitled Hygiene, Allergy and Asthma since this latter symposium addresses many of the same issues, albeit in the context of mucosal inflammation in the pulmonary tract. The first day of the symposium will initially focus on the factors that control the overall development of the mucosal immune system and then turn to the mechanism of tolerance induction in the mucosal immune system. These topics provide the theoretical basis for the understanding of mucosal inflammation. The second day will begin with a plenary session held jointly with the “sister” symposium and will focus on dendritic cell function in the gastrointestinal and pulmonary tracts. It will then conclude with examination of effector and regulatory mechanisms underlying mucosal inflammation. The third day will open with a second joint plenary session in this case considering regulatory (suppressor) mechanism in the gastrointestinal and pulmonary tracts. It will then conclude with an examination of new murine models of mucosal inflammation. The fourth and last day of the symposium will first consider epithelial cell function and mucosal homeostasis, a subject that meshes well with the consideration of environmental factors in pulmonary inflammation being considered in the “sister” symposium. It will then consider the homing of cells to the mucosal mediated by the chemokine system. With this agenda, this Keystone Symposium will provide a keen examination of the major outstanding questions in the area of mucosal inflammation. As such, it will provide major insights into the mechanisms underlying mucosal inflammatory diseases such as inflammatory bowel disease and asthma.
Discounted Abstract Deadline: December 3 2002
Discounted Registration Deadline: February 3 2003
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1 R13 AI053891-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, April 01 | 3:00PM - 7:00PM
Registration
Room: Shavano Peak Foyer


Tuesday, April 01 | 6:15PM - 7:15PM
Welcome
Room: Shavano Peak Foyer


Tuesday, April 01 | 7:15PM - 7:30PM
Orientation
Room: Crestone


Tuesday, April 01 | 7:30PM - 9:30PM
Keynote Addresses
Room: Crestone

Speaker 1 of 2
Patrick G. Holt, University of Western Australia, Australia
Atopy, Asthma and the Hygiene Hypothesis

Tuesday, April 01 | 7:30PM - 9:30PM
Keynote Addresses
Room: Crestone

Speaker 2 of 2
Gabriel Nuñez, University of Michigan, USA
NOD2 Function and its Role in Inflammatory Bowel Disease

Wednesday, April 02 | 7:00AM - 8:00AM
Breakfast
Room: Grays


Wednesday, April 02 | 8:00AM - 11:00AM
The Organization and Development of the Mucosal Immune Syste
m

Room: Crestone Peak

Speaker 1 of 3
David D. Chaplin, University of Alabama at Birmingham, USA
Lymphotoxin Regulation of Lymphoid Organ Structure and Function

Wednesday, April 02 | 8:00AM - 11:00AM
The Organization and Development of the Mucosal Immune Syste
m

Room: Crestone Peak

Speaker 2 of 3
* Hiromichi Ishikawa, Keio University School of Medicine, Japan
Identification of Cryptopatches and Isolated Lymphoid Follicles in the Mouse Small Intestine

Wednesday, April 02 | 8:00AM - 11:00AM
The Organization and Development of the Mucosal Immune Syste
m

Room: Crestone Peak

Speaker 3 of 3
Andrew J.S. Macpherson, University of Bern, Switzerland
Nature of IgA Responses in the Mucosal Immune System

Wednesday, April 02 | 8:00AM - 11:00AM
Epidemiology of Allergic Responses
This session is from Hygiene, Allergy, and Asthma
Room: Red Cloud Peak

Speaker 1 of 5
Erika von Mutius, University Children's Hospital, Munich, Germany
Environmental Factors and the Development of Atopy


Wednesday, April 02 | 8:00AM - 11:00AM
Epidemiology of Allergic Responses
This session is from Hygiene, Allergy, and Asthma
Room: Red Cloud Peak

Speaker 2 of 5
Donata Vercelli, University of Arizona, USA
Regulation of Th2-Dependent Antibody Responses and Allergic Inflammation: Role of Environmental Stimuli


Wednesday, April 02 | 8:00AM - 11:00AM
Epidemiology of Allergic Responses
This session is from Hygiene, Allergy, and Asthma
Room: Red Cloud Peak

Speaker 3 of 5
* Bengt Bjorksten, Karolinska Institute, Sweden
Intestinal Microflora in Allergies


Wednesday, April 02 | 8:00AM - 11:00AM
Epidemiology of Allergic Responses
This session is from Hygiene, Allergy, and Asthma
Room: Red Cloud Peak

Speaker 4 of 5
Maria Yazdanbakhsh, Leiden University Medical Center, Netherlands
Chronic Helminth Infections and Protection from Atopic Disorders: Immunoregulation


Wednesday, April 02 | 8:00AM - 11:00AM
Epidemiology of Allergic Responses
This session is from Hygiene, Allergy, and Asthma
Room: Red Cloud Peak

Speaker 5 of 5
Philip J. Cooper, St George's, University of London, UK
Short Talk: Geohelminth Infections do not Explain the Disassociation between Atopy and Allergic Symptoms among Children Living in a Rural Area of the Tropics


Wednesday, April 02 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Wednesday, April 02 | 11:00AM - 1:00PM
Poster Setup
Room: Shavano/Torreys


Wednesday, April 02 | 1:00PM - 10:00PM
Poster Viewing
Room: Shavano/Torreys


Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 1: Mucosal Responsiveness and Non-Responsiveness
Room: Crestone Peak

Speaker 1 of 10
* Caroline C. Whitacre, Ohio State University, USA

Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 1: Mucosal Responsiveness and Non-Responsiveness
Room: Crestone Peak

Speaker 2 of 10
* Marika C. Kullberg, Centre for Immunology and Infection, University of York, UK

Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 1: Mucosal Responsiveness and Non-Responsiveness
Room: Crestone Peak

Speaker 3 of 10
Monika Gad, Bioneer, Denmark
CD4+ T Cells React with Enterobacterial Antigens in the Absence of CD4+CD25+ T-Cells and Are Regulated by Naive Progenitor CD4+CD25+ T Regulatory Cells

Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 1: Mucosal Responsiveness and Non-Responsiveness
Room: Crestone Peak

Speaker 4 of 10
Marika C. Kullberg, Centre for Immunology and Infection, University of York, UK
Effector and Regulatory CD4+ T Cells in Bacteria-Induced Colitis

Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 1: Mucosal Responsiveness and Non-Responsiveness
Room: Crestone Peak

Speaker 5 of 10
Janneke N. Samsom, Vrije University Medical Center, Netherlands
Signaling via FcgammaRIIB is Eessential for Regulatory T-Cell Induction During Mucosal Tolerance

Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 1: Mucosal Responsiveness and Non-Responsiveness
Room: Crestone Peak

Speaker 6 of 10
Atsushi Mizoguchi, Massachusetts General Hospital, USA
B cells and IL-4 Suppress the Development of Granulomatous Colitis by Regulating Mucosal Dendritic Cells

Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 1: Mucosal Responsiveness and Non-Responsiveness
Room: Crestone Peak

Speaker 7 of 10
Xin-Yuan Fu, National University of Singapore, Singapore
STAT3 Deletion During Hematopoiesis Causes Crohn’s Disease-Like Pathogenesis and Lethality, Revealing a Role of STAT3 in Regulation of Innate Immunity

Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 1: Mucosal Responsiveness and Non-Responsiveness
Room: Crestone Peak

Speaker 8 of 10
LuAnn Thompson-Snipes, Baylor Institute of Immunology Research, USA
Functional Differences in Dendritic Cells in Galphai2 Deficient Mice that Develop IBD

Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 1: Mucosal Responsiveness and Non-Responsiveness
Room: Crestone Peak

Speaker 9 of 10
Kiyoshi Takeda, Osaka University, Japan
Identification of an IL-10-Inducible Gene that Inhibits LPS Responses in Macrophages

Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 1: Mucosal Responsiveness and Non-Responsiveness
Room: Crestone Peak

Speaker 10 of 10
Michal Tomczak, Brigham and Women's Hospital, USA
NF-kappaB is Required Within the Innate Immune System to Inhibit Helicobacter Hepaticus-Induced Colitis and Expression of IL-12 p40

Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 1: Infections and Asthma
This session is from Hygiene, Allergy, and Asthma
Room: Red Cloud Peak

Speaker 1 of 8
* Peter D. Sly, TVWT Telethon Institute for Child Health, Australia
Viral Respiration Infections in the First Year of Life


Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 1: Infections and Asthma
This session is from Hygiene, Allergy, and Asthma
Room: Red Cloud Peak

Speaker 2 of 8
Murali Ramaswamy, University of Iowa, USA
Modulation of Antiviral Gene Expression in Airway Epithelial Cells by Respiratory Syncytial Virus


Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 1: Infections and Asthma
This session is from Hygiene, Allergy, and Asthma
Room: Red Cloud Peak

Speaker 3 of 8
David Voehringer, University Hospital of Erlangen, Germany
Recruitment and Gene Expression Profiles of IL-4 Expressing Cells during Helminth Infection


Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 1: Infections and Asthma
This session is from Hygiene, Allergy, and Asthma
Room: Red Cloud Peak

Speaker 4 of 8
Michelle V. Fanucchi, University of Alabama at Birmingham, USA
Airways Remodeling in Young Adult Rhesus Monkeys is Inhibited by Immunostimulatory DNA Sequences (ISS)


Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 1: Infections and Asthma
This session is from Hygiene, Allergy, and Asthma
Room: Red Cloud Peak

Speaker 5 of 8
Thomas Tao Su, University of California, Los Angeles, USA
A Role for Endogenous Gut Flora and Toll-Like Receptor Signaling in Innate B cell Development


Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 1: Infections and Asthma
This session is from Hygiene, Allergy, and Asthma
Room: Red Cloud Peak

Speaker 6 of 8
Stephanie C. Eisenbarth, Yale University, USA
The Role of LPS Dose in Aeroallergen Sensitization in an Asthma Model


Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 1: Infections and Asthma
This session is from Hygiene, Allergy, and Asthma
Room: Red Cloud Peak

Speaker 7 of 8
Ingegerd Adlerberth, Göteborg University, Sweden
The Intestinal Lactobacillus Flora in Swedish Infants


Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 1: Infections and Asthma
This session is from Hygiene, Allergy, and Asthma
Room: Red Cloud Peak

Speaker 8 of 8
* Gary W. Hunninghake, University of Iowa College of Medicine, USA
RSV Sensitizes Airway Epithelium to Environmental Stimuli


Wednesday, April 02 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Shavano Peak Foyer


Wednesday, April 02 | 5:00PM - 7:00PM
Mechanisms of Tolerance Induction in the Mucosal System
Room: Crestone Peak

Speaker 1 of 3
* Arlene H. Sharpe, Harvard Medical School, USA
The B7:CD28 Superfamily and the Induction of Unresponsiveness

Wednesday, April 02 | 5:00PM - 7:00PM
Mechanisms of Tolerance Induction in the Mucosal System
Room: Crestone Peak

Speaker 2 of 3
Brian R. Champion, PsiOxus Therapeutics Ltd, UK
Notch Signaling and Peripheral T-Cell Immunity

Wednesday, April 02 | 5:00PM - 7:00PM
Mechanisms of Tolerance Induction in the Mucosal System
Room: Crestone Peak

Speaker 3 of 3
Caroline C. Whitacre, Ohio State University, USA
Mucosal Tolerance Targetting Dendritic Cells and T Cells in Experimental Autoimmune Encephalomyelitis (EAE)

Wednesday, April 02 | 5:00PM - 7:00PM
The Natural History of Atopic Diseases
This session is from Hygiene, Allergy, and Asthma
Room: Red Cloud Peak

Speaker 1 of 4
* Thomas A.E. Platts-Mills, University of Virginia, USA
Allergen Exposure, Sensitization and the Development of Asthma


Wednesday, April 02 | 5:00PM - 7:00PM
The Natural History of Atopic Diseases
This session is from Hygiene, Allergy, and Asthma
Room: Red Cloud Peak

Speaker 2 of 4
Charles G. Plopper, University of California, Davis, USA
Experimental Models of Developmental Abnormalities and Asthma Susceptibility from Air Pollutants


Wednesday, April 02 | 5:00PM - 7:00PM
The Natural History of Atopic Diseases
This session is from Hygiene, Allergy, and Asthma
Room: Red Cloud Peak

Speaker 3 of 4
James E. Gern, University of Wisconsin, USA
Cytokine Secretion Patterns, Wheezing and Atopy in Infancy


Wednesday, April 02 | 5:00PM - 7:00PM
The Natural History of Atopic Diseases
This session is from Hygiene, Allergy, and Asthma
Room: Red Cloud Peak

Speaker 4 of 4
Agnes E. Wold, Göteborg University, Sweden
Short Talk: Staphylococci have Replaced Enterobacteria as Dominant in the Neonatal Intestinal Microflora


Wednesday, April 02 | 7:00PM - 8:00PM
Social Hour
Room: Shavano/Torreys


Wednesday, April 02 | 8:00PM - 10:00PM
Poster Session 1
Room: Shavano/Torreys


Thursday, April 03 | 7:00AM - 8:00AM
Breakfast
Room: Grays


Thursday, April 03 | 8:00AM - 11:00AM
Dendritic Cell Function in the GI and Pulmonary Tracts (Join
t)

Room: Crestone/Red Cloud

Speaker 1 of 5
Yong-Jun Liu, Sanofi, USA
Epithelial Cells Trigger Dendritic Cell-Mediated Allergic Inflammation by Producing TSLP

Thursday, April 03 | 8:00AM - 11:00AM
Dendritic Cell Function in the GI and Pulmonary Tracts (Join
t)

Room: Crestone/Red Cloud

Speaker 2 of 5
* Brian L. Kelsall, NIAID, National Institutes of Health, USA
Peyer's Patch Dendritic Cells

Thursday, April 03 | 8:00AM - 11:00AM
Dendritic Cell Function in the GI and Pulmonary Tracts (Join
t)

Room: Crestone/Red Cloud

Speaker 3 of 5
Bart N. Lambrecht, VIB, Ghent University, Belgium
Dendritic Cell Function in Eosinophilic Airway Inflammation

Thursday, April 03 | 8:00AM - 11:00AM
Dendritic Cell Function in the GI and Pulmonary Tracts (Join
t)

Room: Crestone/Red Cloud

Speaker 4 of 5
Kingston H.G. Mills, Trinity College Dublin, Ireland
Induction of Antigen-Specific Regulatory T Cells in the Mucosal Tissues of the Respiratory Tract

Thursday, April 03 | 8:00AM - 11:00AM
Dendritic Cell Function in the GI and Pulmonary Tracts (Join
t)

Room: Crestone/Red Cloud

Speaker 5 of 5
Dale T. Umetsu, Genentech, Inc., USA
Short Talk: Regulation of Pulmonary Inflammation by Dendritic Cells, Regulatory Cells and NKT Cells

Thursday, April 03 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Thursday, April 03 | 11:00AM - 1:00PM
Poster Setup
Room: Shavano/Torreys


Thursday, April 03 | 1:00PM - 10:00PM
Poster Viewing
Room: Shavano/Torreys


Thursday, April 03 | 2:30PM - 4:30PM
Workshop 2: Advances in Mucosal Immunity
Room: Crestone Peak

Speaker 1 of 8
* Brian L. Kelsall, NIAID, National Institutes of Health, USA

Thursday, April 03 | 2:30PM - 4:30PM
Workshop 2: Advances in Mucosal Immunity
Room: Crestone Peak

Speaker 2 of 8
Marianne Quiding-Järbrink, Göteborg University, Sweden
Differential Chemokine Receptor Expression on Human IgA+ and IgG+ B Cells

Thursday, April 03 | 2:30PM - 4:30PM
Workshop 2: Advances in Mucosal Immunity
Room: Crestone Peak

Speaker 3 of 8
Paul M. Arnaboldi, Mount Sinai School of Medicine, USA
IgA Increases the Severity of Inflammation in a Murine Model of Allergic Lung Inflammation

Thursday, April 03 | 2:30PM - 4:30PM
Workshop 2: Advances in Mucosal Immunity
Room: Crestone Peak

Speaker 4 of 8
Steven M. Singer, Georgetown University, USA
Distinct Mechanisms Control Acute and Chronic Infections with Giardia lamblia

Thursday, April 03 | 2:30PM - 4:30PM
Workshop 2: Advances in Mucosal Immunity
Room: Crestone Peak

Speaker 5 of 8
Susan Gilfillan, Washington University School of Medicine, USA
The MHC Class I–Related Molecule MR1 is the Ligand for Evolutionarily Conserved Mucosal-Associated Invariant T (MAIT) Lymphocytes

Thursday, April 03 | 2:30PM - 4:30PM
Workshop 2: Advances in Mucosal Immunity
Room: Crestone Peak

Speaker 6 of 8
Jorge Rodrigo Mora, Takeda Pharmaceuticals, USA
Peyer’s Patch Dendritic Cells Generate Gut-Homing CD8 Effector T Cells

Thursday, April 03 | 2:30PM - 4:30PM
Workshop 2: Advances in Mucosal Immunity
Room: Crestone Peak

Speaker 7 of 8
Jjoern Karhausen, Duke University Medical Center, USA
Epithelial Barrier Function and Intestinal Inflammation; Significance of the Hypoxia Inducible Factor-1 (HIF-1) Pathway.

Thursday, April 03 | 2:30PM - 4:30PM
Workshop 2: Advances in Mucosal Immunity
Room: Crestone Peak

Speaker 8 of 8
Mehri Zareie, Hospital for Sick Children, University of Toronto, Canada
The Prototype Translocating Escherichia coli, Strain C25, Adheres to and Alters Barrier Function of A Model Intestinal Epithelium

Thursday, April 03 | 2:30PM - 4:30PM
Workshop 2: Genetic and Environmental Influences on Allergic
Diseases
This session is from Hygiene, Allergy, and Asthma
Room: Red Cloud Peak

Speaker 1 of 8
* † Donata Vercelli, University of Arizona, USA


Thursday, April 03 | 2:30PM - 4:30PM
Workshop 2: Genetic and Environmental Influences on Allergic
Diseases
This session is from Hygiene, Allergy, and Asthma
Room: Red Cloud Peak

Speaker 2 of 8
* Thomas A. Wynn, Pfizer, USA
Regulation and Function of the Interleukin-13 Receptor Alpha 2: A Key Player in the Hygiene Hypothesis?


Thursday, April 03 | 2:30PM - 4:30PM
Workshop 2: Genetic and Environmental Influences on Allergic
Diseases
This session is from Hygiene, Allergy, and Asthma
Room: Red Cloud Peak

Speaker 3 of 8
Dawn Selander, University of Connecticut Health Center, USA
Perinatal Antigen and Development of Allergic Airway Disease


Thursday, April 03 | 2:30PM - 4:30PM
Workshop 2: Genetic and Environmental Influences on Allergic
Diseases
This session is from Hygiene, Allergy, and Asthma
Room: Red Cloud Peak

Speaker 4 of 8
Claire J. Boog, Netherlands Vaccine Institutes, Netherlands
Predominance of Il-13 Production by Human Neonatal CD8 T Cells


Thursday, April 03 | 2:30PM - 4:30PM
Workshop 2: Genetic and Environmental Influences on Allergic
Diseases
This session is from Hygiene, Allergy, and Asthma
Room: Red Cloud Peak

Speaker 5 of 8
Rebecca A. Shilling, Indiana University School of Medicine, USA
A Novel Polymorphism in the Promoter Region of the ICOS Gene Correlates with Expression on T Lymphocytes and is Associated with Allergic Sensitization.


Thursday, April 03 | 2:30PM - 4:30PM
Workshop 2: Genetic and Environmental Influences on Allergic
Diseases
This session is from Hygiene, Allergy, and Asthma
Room: Red Cloud Peak

Speaker 6 of 8
Malin F. Böttcher, Linkoping University Hospital, Sweden
TLR4 Polymorphism is Associated with Reduced LPS Induced IL-12(p70) and IL-10 Responses and Development of Asthma in Swedish Children


Thursday, April 03 | 2:30PM - 4:30PM
Workshop 2: Genetic and Environmental Influences on Allergic
Diseases
This session is from Hygiene, Allergy, and Asthma
Room: Red Cloud Peak

Speaker 7 of 8
Lisa Cameron, University of Arizona, USA
A Single Nucleotide Polymorphism (SNP) in the 5' Regulatory Region of IL-13 Exhibits Differential Protein Binding that Affects Gene Transcription


Thursday, April 03 | 2:30PM - 4:30PM
Workshop 2: Genetic and Environmental Influences on Allergic
Diseases
This session is from Hygiene, Allergy, and Asthma
Room: Red Cloud Peak

Speaker 8 of 8
Jannine M. Strempel, University of Arizona, USA
CNS-1 is a Potent Enhancer of Human IL-13 Gene Transcription


Thursday, April 03 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Shavano Peak Foyer


Thursday, April 03 | 5:00PM - 7:00PM
Effector and Regulatory Mechanisms of Mucosal Inflammation
Room: Crestone Peak

Speaker 1 of 3
* Bruce H. Horwitz, Brigham and Women's Hospital, USA
Inhibition of Microflora-Induced Colitis by NF-kappaB

Thursday, April 03 | 5:00PM - 7:00PM
Effector and Regulatory Mechanisms of Mucosal Inflammation
Room: Crestone Peak

Speaker 2 of 3
Atsushi Kitani, NIAID, National Institutes of Health, USA
Treatment of Mucosal Inflammation with Genetically Engineered Cells Producing TGF-beta and IL-10

Thursday, April 03 | 5:00PM - 7:00PM
Effector and Regulatory Mechanisms of Mucosal Inflammation
Room: Crestone Peak

Speaker 3 of 3
Markus F. Neurath, University Hospital Erlangen, Germany

Thursday, April 03 | 5:00PM - 7:00PM
Links Between Innate and Adaptive Immunity
This session is from Hygiene, Allergy, and Asthma
Room: Red Cloud Peak

Speaker 1 of 4
Mohamed E.H. Bashir, Massachusetts General Hospital East, USA
Short Talk: Influence of Luminal Flora on Allergic Responses to Food


Thursday, April 03 | 5:00PM - 7:00PM
Links Between Innate and Adaptive Immunity
This session is from Hygiene, Allergy, and Asthma
Room: Red Cloud Peak

Speaker 2 of 4
Donald N. Cook, NIEHS, National Institutes of Health, USA
The Genetics of Innate Immunity in the Lung


Thursday, April 03 | 5:00PM - 7:00PM
Links Between Innate and Adaptive Immunity
This session is from Hygiene, Allergy, and Asthma
Room: Red Cloud Peak

Speaker 3 of 4
* Craig Gerard, Children's Hospital Harvard University, USA
Complement in Asthma


Thursday, April 03 | 5:00PM - 7:00PM
Links Between Innate and Adaptive Immunity
This session is from Hygiene, Allergy, and Asthma
Room: Red Cloud Peak

Speaker 4 of 4
Dale T. Umetsu, Genentech, Inc., USA
Regulation of Immune Response by TIMs


Thursday, April 03 | 7:00PM - 8:00PM
Social Hour
Room: Shavano/Torreys


Thursday, April 03 | 8:00PM - 10:00PM
Poster Session 2
Room: Shavano/Torreys


Friday, April 04 | 7:00AM - 8:00AM
Breakfast
Room: Grays


Friday, April 04 | 8:00AM - 11:00AM
Regulation of Mucosal Responses in the GI and Pulmonary Trac
ts (Joint)

Room: Crestone/Red Cloud

Speaker 1 of 4
* Andrew Caton, Wistar Institute, USA
CD4+ CD25+ Regulatory T cell Selection

Friday, April 04 | 8:00AM - 11:00AM
Regulation of Mucosal Responses in the GI and Pulmonary Trac
ts (Joint)

Room: Crestone/Red Cloud

Speaker 2 of 4
Kazuhiko Nakamura, Kyushu University, Japan
Expression of Cell Surface-Bound TGF-Beta and TGF-Beta-Mediated Immunosuppression by Murine and Human CD4+CD25+ Regulatory T Cells

Friday, April 04 | 8:00AM - 11:00AM
Regulation of Mucosal Responses in the GI and Pulmonary Trac
ts (Joint)

Room: Crestone/Red Cloud

Speaker 3 of 4
Fiona M. Powrie, University of Oxford, UK
Control of Immune Pathology by CD4+CD25+ TR Cells

Friday, April 04 | 8:00AM - 11:00AM
Regulation of Mucosal Responses in the GI and Pulmonary Trac
ts (Joint)

Room: Crestone/Red Cloud

Speaker 4 of 4
Anne O'Garra, Francis Crick Institute, UK
Development and Function of IL-10-Producing Regulatory CD4+ T Cells

Friday, April 04 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Friday, April 04 | 11:00AM - 1:00PM
Poster Setup
Room: Shavano/Torreys


Friday, April 04 | 1:00PM - 10:00PM
Poster Viewing
Room: Shavano/Torreys


Friday, April 04 | 2:30PM - 4:30PM
Workshop 3: Models of Mucosal Inflammation and the Immunolog
y of IBD
Room: Crestone Peak

Speaker 1 of 10
* Markus F. Neurath, University Hospital Erlangen, Germany

Friday, April 04 | 2:30PM - 4:30PM
Workshop 3: Models of Mucosal Inflammation and the Immunolog
y of IBD
Room: Crestone Peak

Speaker 2 of 10
* Joanne L. Viney, Pandion Therapeutics, USA

Friday, April 04 | 2:30PM - 4:30PM
Workshop 3: Models of Mucosal Inflammation and the Immunolog
y of IBD
Room: Crestone Peak

Speaker 3 of 10
Pengfei Zhou, McMaster University, Canada
Ova Feeding Prevention of Colitis in Scid-BG Mice Receiving Ova-Specific TCR Transgenic CD4+CD45RBHI T Cells was Associated With Oral Tolerance

Friday, April 04 | 2:30PM - 4:30PM
Workshop 3: Models of Mucosal Inflammation and the Immunolog
y of IBD
Room: Crestone Peak

Speaker 4 of 10
Baljit Singh, Sir William Dunn School of Pathology, UK
The Role of CD134-CD134L, CD40-CD154 Interactions and Interleukin-12 in the T Cell Transfer Model of Colitis

Friday, April 04 | 2:30PM - 4:30PM
Workshop 3: Models of Mucosal Inflammation and the Immunolog
y of IBD
Room: Crestone Peak

Speaker 5 of 10
Bo Wei, University of California, Los Angeles, USA
Mesenteric CD19+, IgM High B Cells Play a Protective Function in Galpha-i2 T Cell Transferred Colitis Mouse Model

Friday, April 04 | 2:30PM - 4:30PM
Workshop 3: Models of Mucosal Inflammation and the Immunolog
y of IBD
Room: Crestone Peak

Speaker 6 of 10
Siegfried Hapfelmeier, ETHZ, Swiss Federal Institute of Technology, Switzerland
A Murine Model for S. Typhimurium Colitis: Analyzing Mutants of both the Host and the Pathogen

Friday, April 04 | 2:30PM - 4:30PM
Workshop 3: Models of Mucosal Inflammation and the Immunolog
y of IBD
Room: Crestone Peak

Speaker 7 of 10
Jacque N. Wilk, Amgen Inc., USA
Differential Gene Expression of Cytokines and Chemokines in Intestinal Tissue of Mdr1a-/- Mice: Understanding the Mechanistic Basis of Colitis

Friday, April 04 | 2:30PM - 4:30PM
Workshop 3: Models of Mucosal Inflammation and the Immunolog
y of IBD
Room: Crestone Peak

Speaker 8 of 10
Martin H. Holtmann, Johannes Gutenberg University, Germany
Overexpression of Tumor Necrosis Factor Receptor 2 (p80) on CD4 cells Increases Experimental Colitis

Friday, April 04 | 2:30PM - 4:30PM
Workshop 3: Models of Mucosal Inflammation and the Immunolog
y of IBD
Room: Crestone Peak

Speaker 9 of 10
Mauro D'Amato, Karolinska Institute, Sweden
Integrating NOD2/CARD15 Signalling and TNF Promoter Polymorphism in Inflammatory Bowel Disease (IBD)

Friday, April 04 | 2:30PM - 4:30PM
Workshop 3: Models of Mucosal Inflammation and the Immunolog
y of IBD
Room: Crestone Peak

Speaker 10 of 10
Debby Laukens, Ghent University, Belgium
CARD15 Mutations in Patients with Spondyloarthropathy Are Linked with Disease Progression and Evolution to Crohn’s Disease

Friday, April 04 | 2:30PM - 4:30PM
Workshop 3: Immunoregulation of the Allergic Response
This session is from Hygiene, Allergy, and Asthma
Room: Red Cloud Peak

Speaker 1 of 7
* Catherine M. Hawrylowicz, King's College London, UK
A Deficiency in Glucocorticoid-Induced IL-10 Synthesis in T Cells From Glucocorticoid Resistant Asthma Patients: Immune Manipulation to Overcome this Deficiency


Friday, April 04 | 2:30PM - 4:30PM
Workshop 3: Immunoregulation of the Allergic Response
This session is from Hygiene, Allergy, and Asthma
Room: Red Cloud Peak

Speaker 2 of 7
Martin E. Dahl, AnaptysBio, USA
Persistent Viral-Induced Alteration of Chemokine Expression Contributes to the Accumulation of Dendritic Cells and CD4 T Cells in the Lungs of Mice


Friday, April 04 | 2:30PM - 4:30PM
Workshop 3: Immunoregulation of the Allergic Response
This session is from Hygiene, Allergy, and Asthma
Room: Red Cloud Peak

Speaker 3 of 7
Leonie S. van Rijt, Erasmus University Medical Center, Netherlands
In Vivo Depletion and Adoptive Transfer of Dendritic Cells Reveals an Essential Role During the Secondary Response to Inhaled Antigen


Friday, April 04 | 2:30PM - 4:30PM
Workshop 3: Immunoregulation of the Allergic Response
This session is from Hygiene, Allergy, and Asthma
Room: Red Cloud Peak

Speaker 4 of 7
Hamida Hammad, Ghent University & VIB, Belgium
Signalling Through the PGD2 Receptor Inhibits Th2 Sensitization Induced by Dendritic Cells in a Murine Model of Asthma


Friday, April 04 | 2:30PM - 4:30PM
Workshop 3: Immunoregulation of the Allergic Response
This session is from Hygiene, Allergy, and Asthma
Room: Red Cloud Peak

Speaker 5 of 7
Frances E. Lund, University of Alabama at Birmingham, USA
T Cell Priming and Allergen-Induced Inflammatory Responses Are Reduced in CD38 Deficient Mice Due to Defective Dendritic Cell Migration


Friday, April 04 | 2:30PM - 4:30PM
Workshop 3: Immunoregulation of the Allergic Response
This session is from Hygiene, Allergy, and Asthma
Room: Red Cloud Peak

Speaker 6 of 7
Laura Cervi, University of Pennsylvania, USA
Dendritic Cells Can Simultaneously Induce Th1 and Th2 Responses to Distinct Antigens


Friday, April 04 | 2:30PM - 4:30PM
Workshop 3: Immunoregulation of the Allergic Response
This session is from Hygiene, Allergy, and Asthma
Room: Red Cloud Peak

Speaker 7 of 7
* Douglas S. Robinson, Imperial College London, UK
CD4+CD25+ T Cell Suppression of Allergen-Induced T Cell Responses is Deficient in Allergic Patients


Friday, April 04 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Shavano Peak Foyer


Friday, April 04 | 5:00PM - 7:00PM
New Models of Mucosal Inflammation - II
Room: Crestone Peak

Speaker 1 of 3
* Markus F. Neurath, University Hospital Erlangen, Germany
Role of T-bet in Colitis

Friday, April 04 | 5:00PM - 7:00PM
New Models of Mucosal Inflammation - II
Room: Crestone Peak

Speaker 2 of 3
Frank Heller, Germany
NKT-Cells Mediate Oxazalone Colitis, a Murine Model of Ulcerative Colitis, by the Production of IL-13

Friday, April 04 | 5:00PM - 7:00PM
New Models of Mucosal Inflammation - II
Room: Crestone Peak

Speaker 3 of 3
Cox Cornelis Terhorst, Beth Israel Deaconess Medical Center, USA
Macrophage/T Cell Communication in the Lamina Propria

Friday, April 04 | 5:00PM - 7:00PM
Allergen Structure and T Cell Response
This session is from Hygiene, Allergy, and Asthma
Room: Red Cloud Peak

Speaker 1 of 3
* Martin D. Chapman, INDOOR Biotechnologies Inc., USA
Allergen Structure/Function Relationships: Determinants of Allergenicity


Friday, April 04 | 5:00PM - 7:00PM
Allergen Structure and T Cell Response
This session is from Hygiene, Allergy, and Asthma
Room: Red Cloud Peak

Speaker 2 of 3
William Harnett, Strathclyde Institute for Pharmacy and Biomedical Sciences, UK
The Anti-Inflammatory Potential of the Filarial Nematode Secreted Product, ES-62


Friday, April 04 | 5:00PM - 7:00PM
Allergen Structure and T Cell Response
This session is from Hygiene, Allergy, and Asthma
Room: Red Cloud Peak

Speaker 3 of 3
Stephen R. Durham, National Heart and Lung Institute, UK
Immunotherapy of IgE-Mediated Disease


Friday, April 04 | 7:00PM - 8:00PM
Social Hour
Room: Shavano/Torreys


Friday, April 04 | 8:00PM - 10:00PM
Poster Session 3
Room: Shavano/Torreys


Saturday, April 05 | 7:00AM - 8:00AM
Breakfast
Room: Grays


Saturday, April 05 | 8:00AM - 11:00AM
Epithelial Cell Function and Mucosal Homeostasis
Room: Crestone Peak

Speaker 1 of 4
Nadine Cerf-Bensussan, Université Paris Descartes, France
Enterocyte-Derived IL-15: A Key to Disrupted Intraepithelial Lymphocyte Homeostasis and Lymphoid Malignancies in Celiac Disease

Saturday, April 05 | 8:00AM - 11:00AM
Epithelial Cell Function and Mucosal Homeostasis
Room: Crestone Peak

Speaker 2 of 4
Hiroshi Kiyono, University of Tokyo, Japan
New Insights into Mechanisms of Allergic Diseases in the Intestinal Mucosa

Saturday, April 05 | 8:00AM - 11:00AM
Epithelial Cell Function and Mucosal Homeostasis
Room: Crestone Peak

Speaker 3 of 4
* Joanne L. Viney, Pandion Therapeutics, USA
Mucosal Inflammation in Mdr1a Deficient Mice

Saturday, April 05 | 8:00AM - 11:00AM
Epithelial Cell Function and Mucosal Homeostasis
Room: Crestone Peak

Speaker 4 of 4
Richard S. Blumberg, Brigham and Women's Hospital, USA
FcRn-Regulated Transport of Antibody and Antibody-Antigen Immune Complexes Across Intestinal Epithelial Cells during Adult Life

Saturday, April 05 | 8:00AM - 11:00AM
Development and Function of Th2 Cells
This session is from Hygiene, Allergy, and Asthma
Room: Red Cloud Peak

Speaker 1 of 5
Anuradha Ray, University of Pittsburgh School of Medicine, USA
T Cell-Dendritic Cell Interactions in Airway Inflammation and Tolerance


Saturday, April 05 | 8:00AM - 11:00AM
Development and Function of Th2 Cells
This session is from Hygiene, Allergy, and Asthma
Room: Red Cloud Peak

Speaker 2 of 5
* Fred D. Finkelman, University of Cincinnati, USA
Th2 as a Default Response


Saturday, April 05 | 8:00AM - 11:00AM
Development and Function of Th2 Cells
This session is from Hygiene, Allergy, and Asthma
Room: Red Cloud Peak

Speaker 3 of 5
Thomas B. Nutman, NIAID, National Institutes of Health, USA
The Regulation of the Human T Cell Response in the Context of Systemic Helminth Infections


Saturday, April 05 | 8:00AM - 11:00AM
Development and Function of Th2 Cells
This session is from Hygiene, Allergy, and Asthma
Room: Red Cloud Peak

Speaker 4 of 5
Yasmine Belkaid, NIAID, National Institutes of Health, USA
Regulatory T Cells, Chronic Infection and Immunity


Saturday, April 05 | 8:00AM - 11:00AM
Development and Function of Th2 Cells
This session is from Hygiene, Allergy, and Asthma
Room: Red Cloud Peak

Speaker 5 of 5
Max Woisetschläger, Novartis Research Institute, Austria
Short Talk: Modulating the Function of Dendritic Cells and IgE Class Switching by B-Cells: Dual Mode of Action of a Novel Small Molecular Weight Compound


Saturday, April 05 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Saturday, April 05 | 2:30PM - 4:30PM
Workshop 4: Airway Immunity and Novel Therapies for Experime
ntal Mucosal Disease
Room: Crestone Peak

Speaker 1 of 5
* Hiroshi Kiyono, University of Tokyo, Japan

Saturday, April 05 | 2:30PM - 4:30PM
Workshop 4: Airway Immunity and Novel Therapies for Experime
ntal Mucosal Disease
Room: Crestone Peak

Speaker 2 of 5
Muriel Pichavant, Institut Pasteur de Lille, France
Recruitment of Both Interstitial DC and Langerhans Cell Precursors by Allergen-Stimulated Bronchial Epithelial Cells: Implication of CCL20.

Saturday, April 05 | 2:30PM - 4:30PM
Workshop 4: Airway Immunity and Novel Therapies for Experime
ntal Mucosal Disease
Room: Crestone Peak

Speaker 3 of 5
Catherine Duez, Paster Institute of Lille, France
An IL-18 Secreting BCG Vector Prevents Allergic Airway Disease in Mice

Saturday, April 05 | 2:30PM - 4:30PM
Workshop 4: Airway Immunity and Novel Therapies for Experime
ntal Mucosal Disease
Room: Crestone Peak

Speaker 4 of 5
Anton J.M. van Oosterhout, GSK R&D, UK
Allergen Immunotherapy Induces a Suppressor Memory Response Mediated by IL-10 in a Mouse Model of Asthma

Saturday, April 05 | 2:30PM - 4:30PM
Workshop 4: Airway Immunity and Novel Therapies for Experime
ntal Mucosal Disease
Room: Crestone Peak

Speaker 5 of 5
Geetha Srikrishna, Sanford-Burnham Medical Research Institute, USA
Anti-Carboxylate Antibody mAbGB3.1 Blocks Onset of Th-1 Mediated Murine Colitis

Saturday, April 05 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Shavano Peak Foyer


Saturday, April 05 | 5:00PM - 7:00PM
Chemokines and Mucosal Function
Room: Crestone Peak

Speaker 1 of 3
Eric J. Kunkel, USA
Chemokines in B Cell Trafficking to Mucosal Tissues

Saturday, April 05 | 5:00PM - 7:00PM
Chemokines and Mucosal Function
Room: Crestone Peak

Speaker 2 of 3
Konstantinos A. Papadakis, Cedars Sinai Medical Center, USA
The Role of Thymus-Expressed Chemokine (TECK/CCL25) and CC Chemokine Receptor 9 in Small Bowel Immunity and Inflammation

Saturday, April 05 | 5:00PM - 7:00PM
Chemokines and Mucosal Function
Room: Crestone Peak

Speaker 3 of 3
* Bernhard Moser, Cardiff University School of Medicine, UK
Follicular Homing of alphabeta-T Cells and gammadelta-T Cells

Saturday, April 05 | 5:00PM - 6:30PM
Clinical Applications
This session is from Hygiene, Allergy, and Asthma
Room: Red Cloud Peak

Speaker 1 of 4
* Eyal Raz, University of California, San Diego, USA
TLR Signaling Mediates the Anti-Inflammatory Effects of Probiotics on Experimental Colitis


Saturday, April 05 | 5:00PM - 6:30PM
Clinical Applications
This session is from Hygiene, Allergy, and Asthma
Room: Red Cloud Peak

Speaker 2 of 4
Graham A.W. Rook, Royal Free and University College Medical School, UK
“Friendly” Organisms from our Evolutionary Past Act as Adjuvants for Regulatory T Cell Development


Saturday, April 05 | 5:00PM - 6:30PM
Clinical Applications
This session is from Hygiene, Allergy, and Asthma
Room: Red Cloud Peak

Speaker 3 of 4
Edith M. Hessel, Dynavax Technologies, USA
Short Talk: Pulmonary Dendritic Cells and the Regulation of Allergic Inflammation


Saturday, April 05 | 5:00PM - 6:30PM
Clinical Applications
This session is from Hygiene, Allergy, and Asthma
Room: Red Cloud Peak

Speaker 4 of 4
Gilles Marchal, Institut Pasteur, France
Short Talk: Long-Term Treatment with Freeze-Dried BCG Reduces the Recruitment of Eosinophils and DCs in a Model of Allergic Inflammation


Saturday, April 05 | 6:30PM - 7:00PM
Round Table Discussion
This session is from Hygiene, Allergy, and Asthma
Room: Red Cloud Peak


Saturday, April 05 | 7:00PM - 8:00PM
Social Hour
Room: Shavano/Torreys


Saturday, April 05 | 8:00PM - 11:00PM
Entertainment
Room: Shavano/Torreys


Saturday, April 05 | 8:00PM - 11:00PM
Cash Bar
Room: Shavano/Torreys


Sunday, April 06 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.