Web Desc
Rational Design of Vaccines and Immunotherapeutics
joint with Bioterrorism and Emerging Infectious Diseases: Antimicrobials, Therapeutics and Immune-Modulators
Organizer(s): Margaret A. Liu and Peter C. Doherty
Date: January 06 - 11, 2004
Location: Keystone Resort, Keystone, CO, USA
Supported by Keystone Symposia
Summary of Meeting:
The past 2 decades have seen incredible advances in the fields of immunology and molecular biology. Simultaneously, remarkable novel technologies have provided new discovery tools for understanding pathogens and pathophysiology as well as for designing new delivery systems for vaccines and pharmacologic agents. Taken all together, these insights and developments have radically transformed the options for infectious and autoimmune diseases, cancer, and allergy by enabling new targets, new delivery systems, and new types of biologicals. These new agents have the potential to be both more specifically targeted and more precise mechanistically for increased potency and to avoid adverse effects. But to date, and for a variety of reasons, there has been less synergy of all these advances than needed to yield optimal progress towards real breakthrough vaccines and immunotherapies. There is a need for a non-commercial forum that will bring together scientists from the variety of disciplines, from industry as well as academia, and from the different stages of research and development. This meeting will enable scientists from different disciplines and technological backgrounds focusing on various immunological and developmental aspects of vaccines and immunotherapeutics to advance their knowledge in these inter-related areas outside of their own specialties and will provide the opportunity for cross-fertilization and interdisciplinary collaborations. A Keystone Symposium provides an ideal environment for a comprehensive and interactive meeting. The talks are designed to cover critical recent insights that are broadly applicable, while the workshops will enable in-depth coverage of specific topics. Because new technologies and discoveries can be presented in a workshop format, this will enable maximum opportunities for catalysis in order to most rapidly benefit from these diverse insights and developments to develop new ways to harness or control the immune response to prevent or treat the variety of diseases for which the immune system plays a pathological or beneficial role.
Discounted Abstract Deadline: September 15 2003
Discounted Registration Deadline: November 6 2003
We gratefully acknowledge additional support for this conference from:

BD Technologies
Beckman Coulter Foundation, Inc.Bill & Melinda Gates FoundationColey Pharmaceutical Group, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1 U13 AI60000-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, January 06 | 3:00PM - 7:00PM
Registration
Room: Longs Foyer


Tuesday, January 06 | 6:15PM - 7:15PM
Refreshments
Room: Longs Foyer


Tuesday, January 06 | 7:15PM - 7:30PM
Orientation
Room: Grays Peak 1-3


Tuesday, January 06 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Grays Peak 1-3

Speaker 1 of 4
* Connie S. Schmaljohn, US Army Medical Research Institute of Infectious Disease, USA

Tuesday, January 06 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Grays Peak 1-3

Speaker 2 of 4
Julie L. Gerberding, Merck & Co., USA
Preparing for 'The New Normal': Innovations in Countermeasures to Combat Public Health Threats

Tuesday, January 06 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Grays Peak 1-3

Speaker 3 of 4
* Margaret A. Liu, ProTherImmune and Karolinska Institutet, USA

Tuesday, January 06 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Grays Peak 1-3

Speaker 4 of 4
Stanley A. Plotkin, Vaxconsult, LLC, USA
Rational Design of Vaccines: Revolution or Evolution?

Wednesday, January 07 | 7:00AM - 8:00AM
Breakfast
Room: Longs Peak


Wednesday, January 07 | 8:00AM - 11:00AM
T Cell Differentiation and Memory; Pathways of Antigen Proc
essing, Co-Stimulation. Session Sponsored in Part by BD Technologies.

Room: Grays Peak 1-2

Speaker 1 of 4
* Peter C. Doherty, University of Melbourne, Australia
Naïve and Memory T Cells in Viral Infections

Wednesday, January 07 | 8:00AM - 11:00AM
T Cell Differentiation and Memory; Pathways of Antigen Proc
essing, Co-Stimulation. Session Sponsored in Part by BD Technologies.

Room: Grays Peak 1-2

Speaker 2 of 4
Susan M. Kaech, The Salk Institute, USA
Pathways of Memory CD8 T Cell Differentiation

Wednesday, January 07 | 8:00AM - 11:00AM
T Cell Differentiation and Memory; Pathways of Antigen Proc
essing, Co-Stimulation. Session Sponsored in Part by BD Technologies.

Room: Grays Peak 1-2

Speaker 3 of 4
Susan L. Swain, University of Massachusetts Medical School, USA
Regulation of CD4 T Cell Memory Generation

Wednesday, January 07 | 8:00AM - 11:00AM
T Cell Differentiation and Memory; Pathways of Antigen Proc
essing, Co-Stimulation. Session Sponsored in Part by BD Technologies.

Room: Grays Peak 1-2

Speaker 4 of 4
Jay A. Berzofsky, NCI, National Institutes of Health, USA
Role of IL-15 in CD8+ T Cell Memory and Avidity Maturation

Wednesday, January 07 | 8:00AM - 11:00AM
Infectious Clone Technology: What Have We Learned So Far?
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 1 of 5
* Michael J. Buchmeier, University of California Irvine, USA


Wednesday, January 07 | 8:00AM - 11:00AM
Infectious Clone Technology: What Have We Learned So Far?
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 2 of 5
Yoshihiro Kawaoka, University of Wisconsin / University of Tokyo, USA
The Power of Reverse Genetics


Wednesday, January 07 | 8:00AM - 11:00AM
Infectious Clone Technology: What Have We Learned So Far?
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 3 of 5
Adolfo García-Sastre, Mount Sinai School of Medicine, USA
Type I Interferon Antagonists of RNA Viruses: Novel Targets for Attenuation in Live Virus Vaccines


Wednesday, January 07 | 8:00AM - 11:00AM
Infectious Clone Technology: What Have We Learned So Far?
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 4 of 5
Juan Carlos de la Torre, The Scripps Research Institute, USA
Arenavirus Reverse Genetics: Implications for Novel Antiviral Strategies


Wednesday, January 07 | 8:00AM - 11:00AM
Infectious Clone Technology: What Have We Learned So Far?
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 5 of 5
Ute Stroeher, Canadian Science Centre for Human and Animal Health, Canada
Reverse Genetics Systems for High-Containment Viruses: Development and Potential Use


Wednesday, January 07 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Foyer


Wednesday, January 07 | 11:00AM - 1:00PM
Poster Setup
Room: Longs Peak


Wednesday, January 07 | 1:00PM - 10:00PM
Poster Viewing
Room: Longs Peak


Wednesday, January 07 | 2:00PM - 4:00PM
Workshop 1: Skin and Mucosal Delivery of Vaccines
Room: Grays Peak 1-2

Speaker 1 of 9
* John A. Mikszta, BD Technologies, USA

Wednesday, January 07 | 2:00PM - 4:00PM
Workshop 1: Skin and Mucosal Delivery of Vaccines
Room: Grays Peak 1-2

Speaker 2 of 9
* Peter Daddona, Zosano Pharma , Inc., USA

Wednesday, January 07 | 2:00PM - 4:00PM
Workshop 1: Skin and Mucosal Delivery of Vaccines
Room: Grays Peak 1-2

Speaker 3 of 9
Catharine M. Bosio, NIAID, National Institutes of Health, USA
Immunogenicity and Protective Efficacy of Liposome-Based Mucosal Vaccines Against Y. pestis

Wednesday, January 07 | 2:00PM - 4:00PM
Workshop 1: Skin and Mucosal Delivery of Vaccines
Room: Grays Peak 1-2

Speaker 4 of 9
Sophie Chabot, USA
A Novel Intranasal Proteosome-Based Measles Vaccine Induces Neutralizing Antibody Responses in Mice

Wednesday, January 07 | 2:00PM - 4:00PM
Workshop 1: Skin and Mucosal Delivery of Vaccines
Room: Grays Peak 1-2

Speaker 5 of 9
Lakshmi Krishnan, Institute for Biological Sciences, Canada
Delivery of Antigen in Archaeosome Adjuvant Sustains Antigen Presentation and CD8+ CTL Memory in vivo

Wednesday, January 07 | 2:00PM - 4:00PM
Workshop 1: Skin and Mucosal Delivery of Vaccines
Room: Grays Peak 1-2

Speaker 6 of 9
Thomas M. Luby, Abraxis BioScience, USA
Generation of Immune Responses by Immunization with Plasmid DNA Encapsulated in Poly (Lactide-Co-Glycolide) Microparticles is Enhanced by in vivo Electroporation

Wednesday, January 07 | 2:00PM - 4:00PM
Workshop 1: Skin and Mucosal Delivery of Vaccines
Room: Grays Peak 1-2

Speaker 7 of 9
Robert G. Ulrich, Research Institute of Infectious Diseases, USA
Evaluation of New Delivery Devices Targeting the Skin with Recombinant Protein Vaccines

Wednesday, January 07 | 2:00PM - 4:00PM
Workshop 1: Skin and Mucosal Delivery of Vaccines
Room: Grays Peak 1-2

Speaker 8 of 9
Sarah M. Hook, University of Otago, New Zealand
A Formulation Approach to Improving Vaccine Innunogenicity

Wednesday, January 07 | 2:00PM - 4:00PM
Workshop 1: Skin and Mucosal Delivery of Vaccines
Room: Grays Peak 1-2

Speaker 9 of 9
James Matriano, ALZA Corporation, USA
A Rapid and Efficient Skin Patch Technology for Vaccine Delivery

Wednesday, January 07 | 2:00PM - 4:00PM
Workshop 1: Pathogen Receptor Interactions
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 1 of 8
* Paul F. Bates, University of Pennsylvania School of Medicine, USA


Wednesday, January 07 | 2:00PM - 4:00PM
Workshop 1: Pathogen Receptor Interactions
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 2 of 8
Andrea F. Bertolotti-Ciarlet, University of Pennsylvania, USA
Cellular Processing and Antigenic Characterization of Crimean-Congo Hemorrhagic Fever Virus Glycoproteins


Wednesday, January 07 | 2:00PM - 4:00PM
Workshop 1: Pathogen Receptor Interactions
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 3 of 8
Paula M. Cannon, University of Southern California, Keck School of Medicine, USA
Use of alpha-Dystroglycan as a Receptor by the Arenaviruses


Wednesday, January 07 | 2:00PM - 4:00PM
Workshop 1: Pathogen Receptor Interactions
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 4 of 8
David M. Koelle, University of Washington, USA
Intradermal Vaccinia and Skin-Homing T-Cells


Wednesday, January 07 | 2:00PM - 4:00PM
Workshop 1: Pathogen Receptor Interactions
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 5 of 8
Mansour Mohamadzadeh, Tulane Medical School, USA
Targeting HCV NS3-NS4A to Dendritic Cells (DC) via DC-Binding Peptides Induces Potent T Cell Immunity in vivo


Wednesday, January 07 | 2:00PM - 4:00PM
Workshop 1: Pathogen Receptor Interactions
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 6 of 8
Onesmo Mpanju, U.S. Food and Drug Administration, USA
Identification of Critical Amino Acid Residues on Ebola Virus Glycoprotein Required for Cell Entry


Wednesday, January 07 | 2:00PM - 4:00PM
Workshop 1: Pathogen Receptor Interactions
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 7 of 8
Ted C. Pierson, NIAID, National Institutes of Health, USA
Development of Novel Reporter Viruses for the Study of West Nile Virus Entry and its Inhibition


Wednesday, January 07 | 2:00PM - 4:00PM
Workshop 1: Pathogen Receptor Interactions
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 8 of 8
Christopher Premanandan, Ohio State University College of Veterinary Medicine, USA
Interactions of Bacillus anthracis Exotoxins and Cellular Receptors within the Phagolysosome


Wednesday, January 07 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Longs Foyer


Wednesday, January 07 | 5:00PM - 6:15PM
Genomics and Proteomics: Discovery of Antigens and Immune Mo
dulators (Joint)

Room: Grays Peak 1-2

Speaker 1 of 3
* Margaret A. Liu, ProTherImmune and Karolinska Institutet, USA

Wednesday, January 07 | 5:00PM - 6:15PM
Genomics and Proteomics: Discovery of Antigens and Immune Mo
dulators (Joint)

Room: Grays Peak 1-2

Speaker 2 of 3
Peter L. Andersen, Statens Serum Institut, Denmark
Post genomic insights for the design of TB vaccines for pre- and post-infection administration

Wednesday, January 07 | 5:00PM - 6:15PM
Genomics and Proteomics: Discovery of Antigens and Immune Mo
dulators (Joint)

Room: Grays Peak 1-2

Speaker 3 of 3
Daniel J. Carucci, Foundation for the National Institutes of Health, USA
Identification of Malaria Vaccine Antigens by Proteomics and Incorporation into Molecular Vaccine Development

Wednesday, January 07 | 6:15PM - 7:30PM
Genomic Responses to Infection (Joint)
Room: Grays Peak 1-2

Speaker 1 of 3
* Connie S. Schmaljohn, US Army Medical Research Institute of Infectious Disease, USA

Wednesday, January 07 | 6:15PM - 7:30PM
Genomic Responses to Infection (Joint)
Room: Grays Peak 1-2

Speaker 2 of 3
Alan Aderem, Center for Infectious Disease Research, USA
Large Scale Approaches to Dissecting the Innate Immune Response

Wednesday, January 07 | 6:15PM - 7:30PM
Genomic Responses to Infection (Joint)
Room: Grays Peak 1-2

Speaker 3 of 3
David A. Relman, Stanford University, USA
How the Host Classifies Systemic Infection

Wednesday, January 07 | 7:30PM - 8:30PM
Social Hour
Room: Longs Peak


Wednesday, January 07 | 7:30PM - 10:00PM
Poster Session 1
Room: Longs Peak


Thursday, January 08 | 7:00AM - 8:00AM
Breakfast
Room: Longs Peak


Thursday, January 08 | 8:00AM - 11:00AM
Regulating Immune Responses: New Insights into T Helper Cell
s

Room: Grays Peak 1-2

Speaker 1 of 4
Kevin J. Maloy, University of Oxford, UK
Control of Intestinal Inflammation by Regulatory T Cells

Thursday, January 08 | 8:00AM - 11:00AM
Regulating Immune Responses: New Insights into T Helper Cell
s

Room: Grays Peak 1-2

Speaker 2 of 4
Jeffrey A. Bluestone, University of California, San Francisco, USA
Pathways to Tolerance in Autoimmunity

Thursday, January 08 | 8:00AM - 11:00AM
Regulating Immune Responses: New Insights into T Helper Cell
s

Room: Grays Peak 1-2

Speaker 3 of 4
* Robert A. Seder, NIAID, National Institutes of Health, USA
Distinct Lineages of Th1 Memory Cells have Differential Survival in vivo:
Implications for Vaccine Development Against Diseases Requiring Th1 Responses


Thursday, January 08 | 8:00AM - 11:00AM
Regulating Immune Responses: New Insights into T Helper Cell
s

Room: Grays Peak 1-2

Speaker 4 of 4
Ronald N. Germain, NIAID, National Institutes of Health, USA
Self-Recognition and the Foreign Antigen Sensitivity of Naïve T Cells

Thursday, January 08 | 8:00AM - 11:00AM
New Information on Antiviral Mechanism of Action
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 1 of 5
* Robert M. Krug, University of Texas at Austin, USA


Thursday, January 08 | 8:00AM - 11:00AM
New Information on Antiviral Mechanism of Action
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 2 of 5
Raul Andino, University of California, San Francisco, USA
The Fine Line Between Genetic Plasticity and Mutagenesis


Thursday, January 08 | 8:00AM - 11:00AM
New Information on Antiviral Mechanism of Action
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 3 of 5
Erik De Clercq, Katholieke Universiteit Leuven, Belgium
Therapeutic Potential of Nucleoside/Nucleotide Analogs Against Poxvirus Infections


Thursday, January 08 | 8:00AM - 11:00AM
New Information on Antiviral Mechanism of Action
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 4 of 5
Marc S. Collett, Viropharma, Inc., USA
Antiviral Drugs for Virological Threats of Bioterrorism and Emerging Diseases


Thursday, January 08 | 8:00AM - 11:00AM
New Information on Antiviral Mechanism of Action
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 5 of 5
Karl Y. Hostetler, University of California, San Diego, USA
Synthesis and Evaluation of Orally Active Drugs for Orthopoxvirus Infections


Thursday, January 08 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Foyer


Thursday, January 08 | 11:00AM - 1:00PM
Poster Setup
Room: Longs Peak


Thursday, January 08 | 1:00PM - 10:00PM
Poster Viewing
Room: Longs Peak


Thursday, January 08 | 2:00PM - 4:00PM
Workshop 2: Vaccines for Developing Countries: Diseases and
Technologies
Room: Grays Peak 1-2

Speaker 1 of 7
Martin Friede, World Health Organization, Switzerland
Aerosol Delivery of Vaccines: The Measles Aerosol Project

Thursday, January 08 | 2:00PM - 4:00PM
Workshop 2: Vaccines for Developing Countries: Diseases and
Technologies
Room: Grays Peak 1-2

Speaker 2 of 7
Yukio Koide, Hamamatsu University School of Medicine, Japan
Induction of Protective Cellular Immunity Against Mycobacterium tuberculosis by Recombinant Attenuated Self-Destructing Listeria monocytogenes Strains Harboring Eukaryotic Expression Plasmids for Ag85 complex and MPB/MPT51

Thursday, January 08 | 2:00PM - 4:00PM
Workshop 2: Vaccines for Developing Countries: Diseases and
Technologies
Room: Grays Peak 1-2

Speaker 3 of 7
Sandra Verhaagh, Crucell Holland BV, Netherlands
Studies Towards an Adenovirus-Based Malaria Vaccine

Thursday, January 08 | 2:00PM - 4:00PM
Workshop 2: Vaccines for Developing Countries: Diseases and
Technologies
Room: Grays Peak 1-2

Speaker 4 of 7
Carmel B. Stober, University of Cambridge, UK
From Genomes to Vaccines for leishmaniasis

Thursday, January 08 | 2:00PM - 4:00PM
Workshop 2: Vaccines for Developing Countries: Diseases and
Technologies
Room: Grays Peak 1-2

Speaker 5 of 7
Erik Rollman, BioArctic, Sweden
HPV-16 L1 Genes with Inactivated Negative RNA Elements Induce Potent Immune Responses

Thursday, January 08 | 2:00PM - 4:00PM
Workshop 2: Vaccines for Developing Countries: Diseases and
Technologies
Room: Grays Peak 1-2

Speaker 6 of 7
Maria J. Gonzalez, The Scripps Research Institute, USA
Induction of T-Cell Immunity by a Plant Virus Vaccine

Thursday, January 08 | 2:00PM - 4:00PM
Workshop 2: Vaccines for Developing Countries: Diseases and
Technologies
Room: Grays Peak 1-2

Speaker 7 of 7
Martin Friede, World Health Organization, Switzerland
Vaccines and Technologies for Resource-Poor Settings

Thursday, January 08 | 2:00PM - 4:00PM
Workshop 2: Novel Approaches to Therapeutics
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 1 of 7
* Colleen B. Jonsson, University of Louisville, USA


Thursday, January 08 | 2:00PM - 4:00PM
Workshop 2: Novel Approaches to Therapeutics
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 2 of 7
Robert M. Krug, University of Texas at Austin, USA
Special Lecture: Novel Targets for Antivirals: The Multiple Functional Domains of the NS1 Proteins of Human Influenza Viruses


Thursday, January 08 | 2:00PM - 4:00PM
Workshop 2: Novel Approaches to Therapeutics
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 3 of 7
Jeffrey B. Arterburn, New Mexico State University, USA
New Synthetic Nucleoside Antivirals for Hantavirus


Thursday, January 08 | 2:00PM - 4:00PM
Workshop 2: Novel Approaches to Therapeutics
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 4 of 7
Frank Alexander Hamill, S.W. Foundation Biomedical Research, USA
Anti-Ebola, Anti-Lassa and Anti-SARS CoV Activity of Antimicrobial Natural Product Chemicals from Rubus apetalus


Thursday, January 08 | 2:00PM - 4:00PM
Workshop 2: Novel Approaches to Therapeutics
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 5 of 7
Lisa E. Hensley, NIAID, National Institutes of Health, USA
Evaluation of Interferon-beta as a Therapeutic Treatment for Ebola Hemorrhagic Fever in Nonhuman Primates


Thursday, January 08 | 2:00PM - 4:00PM
Workshop 2: Novel Approaches to Therapeutics
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 6 of 7
Benjamin W. Neuman, The Scripps Research Institute, USA
Arenavirus Inside Out: Cryo-EM Structural Studies of Three Arenaviruses


Thursday, January 08 | 2:00PM - 4:00PM
Workshop 2: Novel Approaches to Therapeutics
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 7 of 7
Tibor P. Keler, Celldex Therapeutics, Inc., USA
Development of Fully Human Antibody Against Anthrax Protective Antigen


Thursday, January 08 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Longs Foyer


Thursday, January 08 | 5:00PM - 7:00PM
Innate Immunity: How to Harness or Suppress It
Room: Grays Peak 1-2

Speaker 1 of 4
* Eyal Raz, University of California, San Diego, USA

Thursday, January 08 | 5:00PM - 7:00PM
Innate Immunity: How to Harness or Suppress It
Room: Grays Peak 1-2

Speaker 2 of 4
Peter Aaby, Statens Serum Institut, Denmark
Non-Targeted Effects of Vaccination: Immune Effects and Impact on Additionally Administered Vaccines

Thursday, January 08 | 5:00PM - 7:00PM
Innate Immunity: How to Harness or Suppress It
Room: Grays Peak 1-2

Speaker 3 of 4
Dennis M. Klinman, U.S. Food and Drug Administration, USA
Progress Towards Understanding the Properties of DNA


Thursday, January 08 | 5:00PM - 7:00PM
Innate Immunity: How to Harness or Suppress It
Room: Grays Peak 1-2

Speaker 4 of 4
Heather L. Davis, Pfizer Inc., Canada
Use of CpG TLR9 Agonist as a Vaccine Adjuvant by Parental or Mucosal Routes

Thursday, January 08 | 5:00PM - 7:00PM
Impact of Receptor Binding
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 1 of 3
* John A. T. Young, F.Hoffmann-La Roche Ltd, Switzerland
Anthrax Toxin-Receptor Interactions


Thursday, January 08 | 5:00PM - 7:00PM
Impact of Receptor Binding
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 2 of 3
Paul F. Bates, University of Pennsylvania School of Medicine, USA
Interaction of Ebola Virus Glycoproteins with Host Factors


Thursday, January 08 | 5:00PM - 7:00PM
Impact of Receptor Binding
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 3 of 3
Kathryn V. Holmes, University of Colorado School of Medicine, USA
Determinants of Coronavirus Host Ranges


Thursday, January 08 | 7:00PM - 8:00PM
Social Hour
Room: Longs Peak


Thursday, January 08 | 7:30PM - 10:00PM
Poster Session 2
Room: Longs Peak


Friday, January 09 | 7:00AM - 8:00AM
Breakfast
Room: Longs Peak


Friday, January 09 | 8:00AM - 11:00AM
Delivery Systems and Mucosal Immunization
Room: Grays Peak 1-2

Speaker 1 of 4
Kam W. Leong, Johns Hopkins University in Singapore, Singapore
Formulation and Delivery Aspects of DNA Vaccination

Friday, January 09 | 8:00AM - 11:00AM
Delivery Systems and Mucosal Immunization
Room: Grays Peak 1-2

Speaker 2 of 4
Charles J. Arntzen, Biodesign Institute, Arizona State University, USA
Plant-Derived, Heat-Stable Subunit Vaccines for Oral Immunization

Friday, January 09 | 8:00AM - 11:00AM
Delivery Systems and Mucosal Immunization
Room: Grays Peak 1-2

Speaker 3 of 4
Jean-Marc Balloul, Transgene S.A., France
Antigen + Cytokine Immunotherapy for HPV-Induced Cervical Cancer

Friday, January 09 | 8:00AM - 11:00AM
Delivery Systems and Mucosal Immunization
Room: Grays Peak 1-2

Speaker 4 of 4
Thomas Lehner, Guy's, King's & St. Thomas' Hospital Medical and Dental School, UK
Innate and Adaptive Mucosal Immunity in Protection Against HIV Infection

Friday, January 09 | 8:00AM - 11:00AM
SARS: The First Year
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 1 of 5
* Peter B. Jahrling, National Institutes of Health, USA


Friday, January 09 | 8:00AM - 11:00AM
SARS: The First Year
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 2 of 5
Frank Plummer, Public Health Agency of Canada, Canada
SARS: Lessons Learned in Canada


Friday, January 09 | 8:00AM - 11:00AM
SARS: The First Year
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 3 of 5
Ralph S. Baric, University of North Carolina at Chapel Hill, USA
Reverse Genetics with a Full-Length Infectious cDNA of the Severe Acute Respiratory Disease Syndrome Coronavirus


Friday, January 09 | 8:00AM - 11:00AM
SARS: The First Year
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 4 of 5
Thomas G. Ksiazek, Centers for Disease Control, USA
Identification of a New Coronavirus Associated with Severe Acute Respiratory Syndrome (SARS)


Friday, January 09 | 8:00AM - 11:00AM
SARS: The First Year
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 5 of 5
Mark R. Denison, Vanderbilt University Medical Center, USA
SARS Coronavirus Genetics and Replication


Friday, January 09 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Foyer


Friday, January 09 | 11:00AM - 1:00PM
Poster Setup
Room: Longs Peak


Friday, January 09 | 1:00PM - 10:00PM
Poster Viewing
Room: Longs Peak


Friday, January 09 | 2:00PM - 4:00PM
Workshop 3: Mixed-Modality Vaccines, and Vaccines that Targe
t Dendritic Cells
Room: Grays Peak 1-2

Speaker 1 of 8
* Liisa K. Selin, University of Massachusetts Medical School, USA
The Significance of Heterologous Immunity for Mixed Modality Vaccines

Friday, January 09 | 2:00PM - 4:00PM
Workshop 3: Mixed-Modality Vaccines, and Vaccines that Targe
t Dendritic Cells
Room: Grays Peak 1-2

Speaker 2 of 8
Claire L. Hutchings, University of Oxford, UK
Novel Immunization Strategies using DNA, Poxvirus and Protein Demonstrate a Widely Applicable Method for Simultaneous Induction of Potent Cellular and Humoral Immunity to the Co-Administered Protein and Encoded Antigen

Friday, January 09 | 2:00PM - 4:00PM
Workshop 3: Mixed-Modality Vaccines, and Vaccines that Targe
t Dendritic Cells
Room: Grays Peak 1-2

Speaker 3 of 8
Anne C. Moore, University College Cork, Ireland
Pre-Existing Fowlpox Immunity is Less Inhibitory to Heterologous Prime-Boost Vaccine Strategies Compared to Anti-MVA Immunity

Friday, January 09 | 2:00PM - 4:00PM
Workshop 3: Mixed-Modality Vaccines, and Vaccines that Targe
t Dendritic Cells
Room: Grays Peak 1-2

Speaker 4 of 8
Andreas Mörner, Public Health Agency of Sweden, Sweden
Immunogenicity and Protective Efficacy of Three Different Prime-Boost HIV-1/SIV Vaccine Regimens in Macaques

Friday, January 09 | 2:00PM - 4:00PM
Workshop 3: Mixed-Modality Vaccines, and Vaccines that Targe
t Dendritic Cells
Room: Grays Peak 1-2

Speaker 5 of 8
John Stambas, St. Jude Children's Research Hospital, USA
Robust and Long-Lived Anti-HIV Envelope Responses Following a Prime-Boost-Boost Immunization Strategy

Friday, January 09 | 2:00PM - 4:00PM
Workshop 3: Mixed-Modality Vaccines, and Vaccines that Targe
t Dendritic Cells
Room: Grays Peak 1-2

Speaker 6 of 8
† Markus Cornberg, University of Massachusetts Medical School, USA
Private Specificity of Epitope Specific TCR Repertoire may Determine Patterns of Cross-Reactive T-Cell Responses

Friday, January 09 | 2:00PM - 4:00PM
Workshop 3: Mixed-Modality Vaccines, and Vaccines that Targe
t Dendritic Cells
Room: Grays Peak 1-2

Speaker 7 of 8
Chien-Fu Hung, Johns Hopkins University, USA
Enhancing DNA Vaccine Potency by Combining a Strategy to Prolong Dendritic Cell Life with Intracellular Targeting Strategies

Friday, January 09 | 2:00PM - 4:00PM
Workshop 3: Mixed-Modality Vaccines, and Vaccines that Targe
t Dendritic Cells
Room: Grays Peak 1-2

Speaker 8 of 8
Darrell J. Irvine, Massachusetts Institute of Technology, USA
Design of Vaccines that Regulate Dendritic Cell State and Trafficking

Friday, January 09 | 2:00PM - 4:00PM
Workshop 3: SARS
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 1 of 8
* Jean L. Patterson, Southwest Foundation for Biomedical Research, USA


Friday, January 09 | 2:00PM - 4:00PM
Workshop 3: SARS
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 2 of 8
Michael J. Buchmeier, University of California Irvine, USA
Antisense Morpholino Oligomers Directed Against the 5’-End of the Genome Inhibit SARS Coronavirus Proliferation and Growth


Friday, January 09 | 2:00PM - 4:00PM
Workshop 3: SARS
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 3 of 8
Dimiter S. Dimitrov, National Institutes of Health, USA
Cloning, Expression, Purification and Characterization of Full-Length and Soluble Fragments of the SARS-CoV S Glycoprotein


Friday, January 09 | 2:00PM - 4:00PM
Workshop 3: SARS
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 4 of 8
Kurt I. Kamrud, Ceva Animal Health, USA
Development of an Alphavirus Replicon Vector Vaccine for SARS-CoV


Friday, January 09 | 2:00PM - 4:00PM
Workshop 3: SARS
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 5 of 8
Mark J. Cameron, Toronto General Hospital, Canada
Immune Responses in Patients with Severe Acute Respiratory Syndrome (SARS): Lessons from Cytokine and Gene Expression Profiling, FACS Analysis, and Epitope Mapping


Friday, January 09 | 2:00PM - 4:00PM
Workshop 3: SARS
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 6 of 8
Alessandro Sette, La Jolla Institute for Immunology, USA
Human T-Cell Epitopes in SARS


Friday, January 09 | 2:00PM - 4:00PM
Workshop 3: SARS
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 7 of 8
Graham Simmons, University of Pennsylvania, USA
Severe Acute Respiratory Syndrome-Associated Coronavirus (SARS-CoV) Encoded Spike (S) Glycoprotein Mediates Viral Entry


Friday, January 09 | 2:00PM - 4:00PM
Workshop 3: SARS
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 8 of 8
Jan terMeulen, Immune Design, USA
Mapping of Human B-Cell Epitopes on all Predicted Transmembrane Proteins of the SARS-CoV and Generation of Human Monoclonal Antibodies Against the Virus


Friday, January 09 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Longs Foyer


Friday, January 09 | 5:00PM - 7:00PM
Technologies for APC Targeting, Stimulating Specific Arms of
the Immune System

Room: Grays Peak 1-2

Speaker 1 of 3
Melissa J. Robbiani (Pope), Population Council, USA
Exploiting Dendritic Cells for Improved Vaccines

Friday, January 09 | 5:00PM - 7:00PM
Technologies for APC Targeting, Stimulating Specific Arms of
the Immune System

Room: Grays Peak 1-2

Speaker 2 of 3
* Drew M. Pardoll, Johns Hopkins University School of Medicine, USA
Targeting Different Antigen Processing Pathways for Biased Immune Responses

Friday, January 09 | 5:00PM - 7:00PM
Technologies for APC Targeting, Stimulating Specific Arms of
the Immune System

Room: Grays Peak 1-2

Speaker 3 of 3
Margaret A. Liu, ProTherImmune and Karolinska Institutet, USA

Friday, January 09 | 5:00PM - 7:00PM
Immune Therapy and Immunopotentiation of Disease
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 1 of 4
* Kathryn V. Holmes, University of Colorado School of Medicine, USA


Friday, January 09 | 5:00PM - 7:00PM
Immune Therapy and Immunopotentiation of Disease
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 2 of 4
James D. Marks, University of California, San Francisco, USA
Recombinant Antibodies for Botulinum Neurotoxin Immunotherapy


Friday, January 09 | 5:00PM - 7:00PM
Immune Therapy and Immunopotentiation of Disease
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 3 of 4
Arturo Casadevall, Albert Einstein College of Medicine, USA
Immediate Immunity for Biological Defense - The Passive Antibody Option


Friday, January 09 | 5:00PM - 7:00PM
Immune Therapy and Immunopotentiation of Disease
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 4 of 4
Brent L. Iverson, University of Texas at Austin, USA
New Approaches to Antibody Engineering: An Improved Anti-PA Antibody


Friday, January 09 | 7:00PM - 8:00PM
Social Hour
Room: Longs Peak


Friday, January 09 | 7:30PM - 10:00PM
Poster Session 3
Room: Longs Peak


Saturday, January 10 | 7:30AM - 8:30AM
Breakfast
Room: Longs Peak


Saturday, January 10 | 8:30AM - 11:00AM
Lessons Learned from Diseases Requiring Stimulation of Immun
ity (Cancer, Preventive Vaccines)

Room: Grays Peak 1-2

Speaker 1 of 3
David B. Weiner, Wistar Institute, USA
Engineering Improved DNA Vaccine Immune Responses

Saturday, January 10 | 8:30AM - 11:00AM
Lessons Learned from Diseases Requiring Stimulation of Immun
ity (Cancer, Preventive Vaccines)

Room: Grays Peak 1-2

Speaker 2 of 3
* Nicholas P. Restifo, Lyell, USA
How Lymphodepletion Enhances Autoimmunity and Cancer Regression after the Adoptive Transfer of T Cells

Saturday, January 10 | 8:30AM - 11:00AM
Lessons Learned from Diseases Requiring Stimulation of Immun
ity (Cancer, Preventive Vaccines)

Room: Grays Peak 1-2

Speaker 3 of 3
John D. Clemens, International Vaccine Institute, South Korea
Thinking Downstream to Accelerate the Introduction of New Vaccines for Developing Countries: The Importance of Translational Research

Saturday, January 10 | 8:30AM - 11:00AM
siRNA and Gene Silencing
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 1 of 4
* Arturo Casadevall, Albert Einstein College of Medicine, USA


Saturday, January 10 | 8:30AM - 11:00AM
siRNA and Gene Silencing
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 2 of 4
Carol D. Blair, Colorado State University, USA
Exploiting RNAi to Develop Arbovirus Resistance in Mosquitoes


Saturday, January 10 | 8:30AM - 11:00AM
siRNA and Gene Silencing
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 3 of 4
Charles E. Samuel, University of California, Santa Barbara, USA
Interferon Action, Double-Stranded RNA, and Gene Silencing by RNA Interference


Saturday, January 10 | 8:30AM - 11:00AM
siRNA and Gene Silencing
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 4 of 4
Nancy J. Sullivan, NIAID, National Institutes of Health, USA
Strategies to Inhibit Ebola Virus Infection


Saturday, January 10 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Foyer


Saturday, January 10 | 2:00PM - 4:00PM
Workshop 4: Vaccines and Gene-Delivery Strategies for Biodef
ense and Emerging Diseases
Room: Grays Peak 1-2

Speaker 1 of 7
* Connie S. Schmaljohn, US Army Medical Research Institute of Infectious Disease, USA

Saturday, January 10 | 2:00PM - 4:00PM
Workshop 4: Vaccines and Gene-Delivery Strategies for Biodef
ense and Emerging Diseases
Room: Grays Peak 1-2

Speaker 2 of 7
Darrell R. Galloway, Naval Medical Research Center, USA
DNA Vaccination Against Anthrax - An Update

Saturday, January 10 | 2:00PM - 4:00PM
Workshop 4: Vaccines and Gene-Delivery Strategies for Biodef
ense and Emerging Diseases
Room: Grays Peak 1-2

Speaker 3 of 7
Manisha Gupta, Centers for Disease Control, USA
Perforin is Required for Protection against Ebola Virus Infection

Saturday, January 10 | 2:00PM - 4:00PM
Workshop 4: Vaccines and Gene-Delivery Strategies for Biodef
ense and Emerging Diseases
Room: Grays Peak 1-2

Speaker 4 of 7
Karl J. Ljungberg, Karolinska Institutet, Sweden
SARS Coronavirus Inhibited by siRNA

Saturday, January 10 | 2:00PM - 4:00PM
Workshop 4: Vaccines and Gene-Delivery Strategies for Biodef
ense and Emerging Diseases
Room: Grays Peak 1-2

Speaker 5 of 7
Michael T. Rock, Vanderbilt University Medical Center, USA
Characterization of Immune Responses after Smallpox Immunization

Saturday, January 10 | 2:00PM - 4:00PM
Workshop 4: Vaccines and Gene-Delivery Strategies for Biodef
ense and Emerging Diseases
Room: Grays Peak 1-2

Speaker 6 of 7
Alessandro Sette, La Jolla Institute for Immunology, USA
Dominance in T Cell Responses to Smallpox Vaccination

Saturday, January 10 | 2:00PM - 4:00PM
Workshop 4: Vaccines and Gene-Delivery Strategies for Biodef
ense and Emerging Diseases
Room: Grays Peak 1-2

Speaker 7 of 7
Søren Buus, University of Copenhagen, Denmark
SARS CTL Vaccine Candidates; HLA Supertype-, Genome-Wide Scanning and Biochemical Validation

Saturday, January 10 | 2:00PM - 4:00PM
Workshop 4: Host Responses
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 1 of 9
* Barry J. Beaty, Colorado State University, USA


Saturday, January 10 | 2:00PM - 4:00PM
Workshop 4: Host Responses
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 2 of 9
Igor M. Belyakov, National Cancer Institute, National Institutes of Health, USA
Shared Modes of Protection against Poxvirus Infection by Attenuated and Conventional Smallpox Vaccine Viruses


Saturday, January 10 | 2:00PM - 4:00PM
Workshop 4: Host Responses
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 3 of 9
Jason W. Botten, The Scripps Research Institute, USA
Identification of Human Cytotoxic T Lymphocyte Epitopes Present in Lassa Virus


Saturday, January 10 | 2:00PM - 4:00PM
Workshop 4: Host Responses
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 4 of 9
Shane Crotty, La Jolla Institute for Immunology, USA
Long Term B Cell Memory in Humans after Smallpox Vaccination


Saturday, January 10 | 2:00PM - 4:00PM
Workshop 4: Host Responses
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 5 of 9
Menzo J. E. Havenga, Crucell Holland BV, Netherlands
Immunogenicity of Prototype Adenovirus-Based Ebola Vaccines in the Absence and Presence of Pre-Existing Adenovirus Immunity


Saturday, January 10 | 2:00PM - 4:00PM
Workshop 4: Host Responses
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 6 of 9
Malachy I. Okeke, University of Tromsø, Norway, Norway
Characterization of Recombinant Viruses Obtained by Co-Infection of BHK-21 Cells with a Live Vaccinia Virus Vectored Influenza Vaccine and a Naturally Occurring Cowpox Virus


Saturday, January 10 | 2:00PM - 4:00PM
Workshop 4: Host Responses
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 7 of 9
Ted M. Ross, University of Georgia, USA
Using C3d to Enhance Immune Responses to Infectious Agents


Saturday, January 10 | 2:00PM - 4:00PM
Workshop 4: Host Responses
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 8 of 9
Amy C. Shurtleff, SRI International, USA
Production and Evaluation of a DNA Vaccine Against Lassa Virus in a Guinea Pig Infection Model


Saturday, January 10 | 2:00PM - 4:00PM
Workshop 4: Host Responses
This session is from Bioterrorism
Room: Grays Peak 3

Speaker 9 of 9
Christina F. Spiropoulou, Centers for Disease Control, USA
Hantavirus Infection Stimulates the MAPK/ERK Signaling Pathway to Produce Proinflammatory Chemokines


Saturday, January 10 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Longs Foyer


Saturday, January 10 | 5:00PM - 7:00PM
Lessons Learned from Diseases Requiring Altering Immunity (A
utoimmunity, Allergy)

Room: Grays Peak 1-2

Speaker 1 of 3
* Lawrence Steinman, Stanford University, USA
Reverse Genomics: Protein Microarrays Guide Tolerizing DNA Vaccine Treatment of Autoimmune Diseases

Saturday, January 10 | 5:00PM - 7:00PM
Lessons Learned from Diseases Requiring Altering Immunity (A
utoimmunity, Allergy)

Room: Grays Peak 1-2

Speaker 2 of 3
Gabriel Nussbaum, Hebrew University of Jerusalem, Israel
HSP60 Peptide Treatment of Autoimmune Diabetes

Saturday, January 10 | 5:00PM - 7:00PM
Lessons Learned from Diseases Requiring Altering Immunity (A
utoimmunity, Allergy)

Room: Grays Peak 1-2

Speaker 3 of 3
Eyal Raz, University of California, San Diego, USA
Probiotics for Inflammatory Bowel Disease: Mystery Unfolding

Saturday, January 10 | 5:00PM - 7:00PM
Circumventing and Directing the Immune Respone with Genetic
Engineering
This session is from Bioterrorism

Room: Grays Peak 3

Speaker 1 of 4
* Charles E. Samuel, University of California, Santa Barbara, USA


Saturday, January 10 | 5:00PM - 7:00PM
Circumventing and Directing the Immune Respone with Genetic
Engineering
This session is from Bioterrorism

Room: Grays Peak 3

Speaker 2 of 4
Joel R. Haynes, LigoCyte Pharmaceuticals, Inc., USA
Genetic Adjuvants for DNA Vaccines


Saturday, January 10 | 5:00PM - 7:00PM
Circumventing and Directing the Immune Respone with Genetic
Engineering
This session is from Bioterrorism

Room: Grays Peak 3

Speaker 3 of 4
Christopher P. Locher, Maxygen, Inc., USA
Development of a Novel Vaccines using DNA Shuffling/Screening Strategies and Bacillus Spore Display


Saturday, January 10 | 5:00PM - 7:00PM
Circumventing and Directing the Immune Respone with Genetic
Engineering
This session is from Bioterrorism

Room: Grays Peak 3

Speaker 4 of 4
R. Mark L. Buller, St. Louis University, USA
IL-4 Enhancement of Poxvirus Lethality: Implications for Small Pox


Saturday, January 10 | 7:00PM - 8:00PM
Social Hour
Room: Longs Peak


Saturday, January 10 | 8:00PM - 11:00PM
Entertainment
Room: Longs Peak


Saturday, January 10 | 8:00PM - 11:00PM
Cash Bar
Room: Longs Peak


Sunday, January 11 | 10:26AM - 10:26AM
Departure


*Session Chair.