Web Desc
Lymphocyte Activation and Signaling
Organizer(s): Susan K. Pierce and Gary A. Koretzky
Date: January 08 - 13, 2004
Location: Sheraton Steamboat Resort, Steamboat Springs, Colorado, USA
Sponsored by Berlex Biosciences and the Director's Sponsor Fund
For important information on the coronavirus, please click here
Summary of Meeting:
The cells of the immune system are armed with a dizzying array of signaling receptors requiring them to integrate an enormous amount of information about their environment to mount the appropriate biologic response. Over the last several years much has been learned about the biochemical nature of the signaling cascades initiated by interactions of individual receptors with their ligands. Indeed, for many immune cell receptors the second messenger pathways have been described in exquisite detail and have been the focus of several national and international meetings. This progress presents an exciting new challenge, namely, to understand how multiple signals are integrated in the context of the entire cell to bring about the ultimate cellular response. Frameworks for understanding signaling at the level of the whole cell have been provided by important new concepts emerging in both cell and molecular biology. These concern the spatial organization of signaling receptors, the integration of signals emanating for multiple receptors and the influence of such signals on gene expression. Significantly, much of the recently gained knowledge of immune cell signaling is having a direct impact on important clinical areas including: autoimmunity, immunodeficiency, vaccines, tumor immunity, transplantation and infectious diseases. Distinguished scientists working at the cutting edge of immune cell signaling will describe their new findings and address how these issues relate to human disease. Speakers will describe the spatial organization of immune cell receptors in the plasma membrane and interactions of receptors with the cytoskeleton and molecular adaptors. The molecular nature of the integration of signals will be described for both the adaptive immune system’s antigen receptors and coreceptors as well as the innate system’s receptors. How the integrated signals ultimately affect chromatin structure and gene regulation will be described. Signaling will also be discussed in the global processes of chemotaxis, homeostasis, response to viral infection, apoptosis and immune deficiencies. Lastly, the next frontier--visualizing signaling in vivo--will be addressed. The proposed meeting will provide a view of how the initial encounter of immune cell signaling receptor with their ligands ultimately leads to the biological response be it activation, differentiation, movement, or cell death and how this knowledge is being translated to important clinical problems.
Discounted Abstract Deadline: September 16 2003
Discounted Registration Deadline: November 10 2003
We gratefully acknowledge additional support for this conference from:
Berlex Biosciences
Cell Signaling Technology, Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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Program

Thursday, January 08 | 3:00PM - 7:00PM
Registration
Room: Foyer


Thursday, January 08 | 6:15PM - 7:15PM
Refreshments
Room: Foyer


Thursday, January 08 | 7:15PM - 7:30PM
Orientation
Room: Storm Peak/Mt. Werner


Thursday, January 08 | 7:30PM - 8:30PM
Keynote Address
Room: Storm Peak/Mt. Werner

Speaker 1 of 1
Arthur Weiss, University of California, San Francisco, USA
Regulating Antigen Receptor Signaling


Friday, January 09 | 7:00AM - 8:00AM
Breakfast
Room: 3 Saddles/Sevens


Friday, January 09 | 8:00AM - 11:00AM
Spatial Organization of Immune Cell Receptors: Rafts, Polari
zation, Synapse Formation

Room: Storm Peak/Mt. Werner

Speaker 1 of 5
* Susan K. Pierce, NIAID, National Institutes of Health, USA
Spatial Organization of B Cell Signaling Receptors

Friday, January 09 | 8:00AM - 11:00AM
Spatial Organization of Immune Cell Receptors: Rafts, Polari
zation, Synapse Formation

Room: Storm Peak/Mt. Werner

Speaker 2 of 5
Abraham Kupfer, Johns Hopkins University, USA
Visualizing T Cell Activation in SMACs

Friday, January 09 | 8:00AM - 11:00AM
Spatial Organization of Immune Cell Receptors: Rafts, Polari
zation, Synapse Formation

Room: Storm Peak/Mt. Werner

Speaker 3 of 5
Michael L. Dustin, University of Oxford, UK
Molecular and Physical Dissection of the Immunological Synapse

Friday, January 09 | 8:00AM - 11:00AM
Spatial Organization of Immune Cell Receptors: Rafts, Polari
zation, Synapse Formation

Room: Storm Peak/Mt. Werner

Speaker 4 of 5
Akihiro Kusumi, Kyoto University, Japan
Engagement a GPI-Anchored Protein Creates Signaling Rafts from Smaller, Transient, Lipid Rafts: A Single-Molecule Approach

Friday, January 09 | 8:00AM - 11:00AM
Spatial Organization of Immune Cell Receptors: Rafts, Polari
zation, Synapse Formation

Room: Storm Peak/Mt. Werner

Speaker 5 of 5
Edward J. Evans, University of Oxford, UK
Short Talk: Signalling Implications of the Structure of CD28:Fab Complex

Friday, January 09 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Friday, January 09 | 11:00AM - 1:00PM
Poster Setup
Room: Sunshine Peak


Friday, January 09 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunshine Peak


Friday, January 09 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Foyer


Friday, January 09 | 5:00PM - 7:00PM
Early Events in Signaling: Adaptors and the Cytoskeleton
Room: Storm Peak/Mt. Werner

Speaker 1 of 3
* Gary A. Koretzky, University of Pennsylvania School of Medicine, USA
Integration of Proximal Signals Following TCR Engagement

Friday, January 09 | 5:00PM - 7:00PM
Early Events in Signaling: Adaptors and the Cytoskeleton
Room: Storm Peak/Mt. Werner

Speaker 2 of 3
Janis K. Burkhardt, University of Pennsylvania School of Medicine, USA
Bipolar Order: Cytoskeletal Control of T Cell Activation

Friday, January 09 | 5:00PM - 7:00PM
Early Events in Signaling: Adaptors and the Cytoskeleton
Room: Storm Peak/Mt. Werner

Speaker 3 of 3
Burkhart L. Schraven, Otto-von-Guericke University Magdeburg, Germany
Transmembrane Adaptor Proteins in Lymphocyte Signaling

Friday, January 09 | 7:00PM - 8:00PM
Social Hour
Room: Foyer


Friday, January 09 | 7:30PM - 10:00PM
Poster Session 1
Room: Sunshine Peak


Saturday, January 10 | 7:00AM - 8:00AM
Breakfast
Room: 3 Saddles/Sevens


Saturday, January 10 | 8:00AM - 11:00AM
Integration and Regulation of Signaling in the Adaptive Syst
em

Room: Storm Peak/Mt. Werner

Speaker 1 of 5
Michael Reth, Albert-Ludwigs University Freiburg, Germany
Rebuilding the Signaling Pathways from the BCR

Saturday, January 10 | 8:00AM - 11:00AM
Integration and Regulation of Signaling in the Adaptive Syst
em

Room: Storm Peak/Mt. Werner

Speaker 2 of 5
Jeffrey V. Ravetch, Rockefeller University, USA
The Fc Receptors in Immune Responses

Saturday, January 10 | 8:00AM - 11:00AM
Integration and Regulation of Signaling in the Adaptive Syst
em

Room: Storm Peak/Mt. Werner

Speaker 3 of 5
Pamela L. Schwartzberg, NIAID, NHGRI, National Institutes of Health, USA
Integrating T Cell Signaling

Saturday, January 10 | 8:00AM - 11:00AM
Integration and Regulation of Signaling in the Adaptive Syst
em

Room: Storm Peak/Mt. Werner

Speaker 4 of 5
* Christopher C. Goodnow, Garvan Institute of Medical Research, Australia
Immunogenic versus Tolerogenic Signaling by Antigen Receptors

Saturday, January 10 | 8:00AM - 11:00AM
Integration and Regulation of Signaling in the Adaptive Syst
em

Room: Storm Peak/Mt. Werner

Speaker 5 of 5
Amrie C. Grammer, AMPEL BioSolutions LLC, USA
Short Talk: Abnormal Signaling Associated with a Naturally Occuring CD40 Mutation in Patients with Systemic Lupus Erythematosus

Saturday, January 10 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Saturday, January 10 | 11:00AM - 1:00PM
Poster Setup
Room: Sunshine Peak


Saturday, January 10 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunshine Peak


Saturday, January 10 | 2:00PM - 4:00PM
Workshop 1: Regulation of Signaling in the Adaptive System
Room: Storm Peak/Mt. Werner

Speaker 1 of 9
* Janis K. Burkhardt, University of Pennsylvania School of Medicine, USA

Saturday, January 10 | 2:00PM - 4:00PM
Workshop 1: Regulation of Signaling in the Adaptive System
Room: Storm Peak/Mt. Werner

Speaker 2 of 9
Lisa A. Miosge, John Curtin School of Medical Research, Australia
Elevated Immunoglobulin Isotypes are a Consequence of Inefficient TCR Signaling Resulting from a slp-76 Hypomorphic Allele

Saturday, January 10 | 2:00PM - 4:00PM
Workshop 1: Regulation of Signaling in the Adaptive System
Room: Storm Peak/Mt. Werner

Speaker 3 of 9
Stephen C. Bunnell, Tufts University School of Medicine, USA
Cooperative Interactions Govern the Persistence and Translocation of the T Cell Signalosome

Saturday, January 10 | 2:00PM - 4:00PM
Workshop 1: Regulation of Signaling in the Adaptive System
Room: Storm Peak/Mt. Werner

Speaker 4 of 9
Thomas Gajewski, University of Chicago, USA
T Cell Anergy is Reversed by Active Ras and Regulated by Diacylglycerol Kinase

Saturday, January 10 | 2:00PM - 4:00PM
Workshop 1: Regulation of Signaling in the Adaptive System
Room: Storm Peak/Mt. Werner

Speaker 5 of 9
Jin H. Kim, University of North Carolina at Chapel Hill, USA
Independent Trafficking of Ig-a/b and mm is Facilitated by Dissociation of the BCR Complex

Saturday, January 10 | 2:00PM - 4:00PM
Workshop 1: Regulation of Signaling in the Adaptive System
Room: Storm Peak/Mt. Werner

Speaker 6 of 9
Ingrid Mecklenbräuker, Rockefeller University, USA
PKC delta Controls Survival of Peripheral B Cells

Saturday, January 10 | 2:00PM - 4:00PM
Workshop 1: Regulation of Signaling in the Adaptive System
Room: Storm Peak/Mt. Werner

Speaker 7 of 9
Virginia S. Shapiro, Mayo Graduate School College of Medicine, USA
Role for a Novel Adaptor, ALX, in CD28 Signaling

Saturday, January 10 | 2:00PM - 4:00PM
Workshop 1: Regulation of Signaling in the Adaptive System
Room: Storm Peak/Mt. Werner

Speaker 8 of 9
Takeshi Tsubata, Tokyo Medical and Dental University, Japan
Immunoglobulin Isotype-Specific Regulation of B Cell Antigen Receptor Signaling

Saturday, January 10 | 2:00PM - 4:00PM
Workshop 1: Regulation of Signaling in the Adaptive System
Room: Storm Peak/Mt. Werner

Speaker 9 of 9
Timothy S. Gomez, Mayo Graduate School, USA
The Large GTPase Dynamin2 Physically Interacts with Vav1 and is Required for T Cell Activation

Saturday, January 10 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Foyer


Saturday, January 10 | 5:00PM - 7:00PM
Integration of Signaling in the Innate System through Activa
ting and Inhibitory Receptors

Room: Storm Peak/Mt. Werner

Speaker 1 of 3
* David H. Raulet, University of California, Berkeley, USA
NK Receptors and the Regulation of Immunity

Saturday, January 10 | 5:00PM - 7:00PM
Integration of Signaling in the Innate System through Activa
ting and Inhibitory Receptors

Room: Storm Peak/Mt. Werner

Speaker 2 of 3
Rafi Ahmed, Emory University School of Medicine, USA
Memory CD8 T Cell Differentiation During Acute Versus Chronic Viral Infection

Saturday, January 10 | 5:00PM - 7:00PM
Integration of Signaling in the Innate System through Activa
ting and Inhibitory Receptors

Room: Storm Peak/Mt. Werner

Speaker 3 of 3
Oreste Acuto, University of Oxford, UK
Short Talk: Costimulation-Induced Protein Methylation in T Cells

Saturday, January 10 | 7:00PM - 8:00PM
Social Hour
Room: Foyer


Saturday, January 10 | 7:30PM - 10:00PM
Poster Session 2
Room: Sunshine Peak


Sunday, January 11 | 7:00AM - 8:00AM
Breakfast
Room: 3 Saddles/Sevens


Sunday, January 11 | 8:00AM - 11:00AM
Signaling through Innate System Receptors
Room: Storm Peak/Mt. Werner

Speaker 1 of 5
Jules A. Hoffmann, Institute of Cellular and Molecular Biology, France
Recognition and Signaling in the Immune Response of Drosophila

Sunday, January 11 | 8:00AM - 11:00AM
Signaling through Innate System Receptors
Room: Storm Peak/Mt. Werner

Speaker 2 of 5
Ruslan Medzhitov, HHMI/Yale University School of Medicine, USA
Toll Mediated Control of Adaptive Immunity

Sunday, January 11 | 8:00AM - 11:00AM
Signaling through Innate System Receptors
Room: Storm Peak/Mt. Werner

Speaker 3 of 5
* Ann Marshak-Rothstein, University of Massachusetts Medical School, USA
Toll Receptor Ligands in Systemic Autoimmune Disease

Sunday, January 11 | 8:00AM - 11:00AM
Signaling through Innate System Receptors
Room: Storm Peak/Mt. Werner

Speaker 4 of 5
Daniel M. Davis, Imperial College London, UK
Short Talk: The NK Cell Immune Synapse

Sunday, January 11 | 8:00AM - 11:00AM
Signaling through Innate System Receptors
Room: Storm Peak/Mt. Werner

Speaker 5 of 5
Christopher E. Rudd, University of Montreal, Canada
Short Talk: A Revised Model of CTLA-4 Signaling

Sunday, January 11 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Sunday, January 11 | 11:00AM - 1:00PM
Poster Setup
Room: Sunshine Peak


Sunday, January 11 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunshine Peak


Sunday, January 11 | 2:00PM - 4:00PM
Workshop 2: Immunological Memory and Effector Functions
Room: Storm Peak/Mt. Werner

Speaker 1 of 9
* Rafi Ahmed, Emory University School of Medicine, USA

Sunday, January 11 | 2:00PM - 4:00PM
Workshop 2: Immunological Memory and Effector Functions
Room: Storm Peak/Mt. Werner

Speaker 2 of 9
Shannon Anderson, University of California, San Francisco, USA
Development and Maintenance of a Memory B Cell Population

Sunday, January 11 | 2:00PM - 4:00PM
Workshop 2: Immunological Memory and Effector Functions
Room: Storm Peak/Mt. Werner

Speaker 3 of 9
Sarah E. Bell, Babraham Institute, UK
PLCgamma2 Regulates Development of Follicular and Marginal Zone B Cells through a Bcl2-Dependent Mechanism

Sunday, January 11 | 2:00PM - 4:00PM
Workshop 2: Immunological Memory and Effector Functions
Room: Storm Peak/Mt. Werner

Speaker 4 of 9
Jessica C. Fanzo, Doris Duke Charitable Foundation, USA
Requirement of IBP in T Cell Effector Function

Sunday, January 11 | 2:00PM - 4:00PM
Workshop 2: Immunological Memory and Effector Functions
Room: Storm Peak/Mt. Werner

Speaker 5 of 9
Laurent P. Malherbe, The Scripps Research Institute, USA
Impact of TCR Binding Properties on T Helper Cell Clonal Expansion and Survival in vivo

Sunday, January 11 | 2:00PM - 4:00PM
Workshop 2: Immunological Memory and Effector Functions
Room: Storm Peak/Mt. Werner

Speaker 6 of 9
Jeffrey C. Rathmell, Vanderbilt University, USA
Trophic Signal Accessibility Regulates Bax Activation, Homeostatic Proliferation, and Chemotaxis

Sunday, January 11 | 2:00PM - 4:00PM
Workshop 2: Immunological Memory and Effector Functions
Room: Storm Peak/Mt. Werner

Speaker 7 of 9
David A. Schaer, Memorial Sloan-Kettering Cancer Center, USA
TCR Signaling Defects Abrogate Lytic Function in CD8+ Tumor Infiltrating Lymphocytes

Sunday, January 11 | 2:00PM - 4:00PM
Workshop 2: Immunological Memory and Effector Functions
Room: Storm Peak/Mt. Werner

Speaker 8 of 9
Andrea L. Szymczak-Workman, St. Jude Children's Research Hospital, USA
Contrasting Requirements of AP-2-Mediated Internalization of the T Cell Receptor: CD3 Complex

Sunday, January 11 | 2:00PM - 4:00PM
Workshop 2: Immunological Memory and Effector Functions
Room: Storm Peak/Mt. Werner

Speaker 9 of 9
Yoshimasa Takahashi, National Institute of Infectious Diseases, Japan
Unique Role of p21ras Cascade on the Memory B Cell Response

Sunday, January 11 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Foyer


Sunday, January 11 | 5:00PM - 7:00PM
Late Events in Immune Cell Signaling: Chromatin Structure an
d Gene Regulation

Room: Storm Peak/Mt. Werner

Speaker 1 of 3
* Yehudit Bergman, Hebrew University Medical School, Israel
Allelic Exclusion in the Immune System

Sunday, January 11 | 5:00PM - 7:00PM
Late Events in Immune Cell Signaling: Chromatin Structure an
d Gene Regulation

Room: Storm Peak/Mt. Werner

Speaker 2 of 3
Katia Georgopoulos, Massachusetts General Hospital, USA
Regulation of Lymphocyte Development by Ikaros

Sunday, January 11 | 5:00PM - 7:00PM
Late Events in Immune Cell Signaling: Chromatin Structure an
d Gene Regulation

Room: Storm Peak/Mt. Werner

Speaker 3 of 3
Gerald R. Crabtree, Stanford University, USA
Preparing Chromatin to Receive Signals: The Earliest Step in Signal Transduction

Sunday, January 11 | 7:00PM - 8:00PM
Social Hour
Room: Foyer


Sunday, January 11 | 7:30PM - 10:00PM
Poster Session 3
Room: Sunshine Peak


Monday, January 12 | 7:00AM - 8:00AM
Breakfast
Room: 3 Saddles/Sevens


Monday, January 12 | 8:00AM - 11:00AM
Signals Controlling Biological Responses
Room: Storm Peak/Mt. Werner

Speaker 1 of 4
Philippa C. Marrack, HHMI/National Jewish Health, USA
Bim and IL-2 Related Cytokines and Lymphocyte Homeostasis


Monday, January 12 | 8:00AM - 11:00AM
Signals Controlling Biological Responses
Room: Storm Peak/Mt. Werner

Speaker 2 of 4
* Christine A. Biron, Brown University, USA
Cytokine Signals in Immune Responses to Viral Infections

Monday, January 12 | 8:00AM - 11:00AM
Signals Controlling Biological Responses
Room: Storm Peak/Mt. Werner

Speaker 3 of 4
Steven L. Reiner, Columbia University, USA
Fashioning and Re-Fashioning T Cell Fates

Monday, January 12 | 8:00AM - 11:00AM
Signals Controlling Biological Responses
Room: Storm Peak/Mt. Werner

Speaker 4 of 4
Deborah J. Fowell, University of Rochester, USA
Short Talk: TCR Signals for Regulated Cytokine Secretion

Monday, January 12 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Monday, January 12 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Foyer


Monday, January 12 | 5:00PM - 7:00PM
Signaling and Cell Activation Imaged in Living Cells and in
vivo

Room: Storm Peak/Mt. Werner

Speaker 1 of 3
Richard S. Lewis, Stanford University School of Medicine, USA
Positive Selection in 4 Dimensions: Visualizing Calcium Signals and Cell Motility in a Living Thymic Slice

Monday, January 12 | 5:00PM - 7:00PM
Signaling and Cell Activation Imaged in Living Cells and in
vivo

Room: Storm Peak/Mt. Werner

Speaker 2 of 3
Ellen A. Robey, University of California, Berkeley, USA
The Cellular Dynamics of MHC Recognition within Lymphoid Tissue

Monday, January 12 | 5:00PM - 7:00PM
Signaling and Cell Activation Imaged in Living Cells and in
vivo

Room: Storm Peak/Mt. Werner

Speaker 3 of 3
* Ronald N. Germain, NIAID, National Institutes of Health, USA
Visualizing Cell Interactions during Adaptive Immune Responses

Monday, January 12 | 7:00PM - 8:00PM
Social Hour
Room: Foyer


Monday, January 12 | 8:00PM - 11:00PM
Entertainment
Room: Sunshine/Mt. Werner


Monday, January 12 | 8:00PM - 11:00PM
Cash Bar
Room: Sunshine/Mt. Werner


Tuesday, January 13 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.