Web Desc
NF-kappaB: Biology and Pathology
Organizer(s): Ulrich K. Siebenlist, Anjana Rao and Sankar Ghosh
Date: January 11 - 16, 2004
Location: Snowbird Resort, Snowbird, UT, USA
Sponsored by Lilly Research Laboratories and the Director's Sponsor Fund
For important information on the coronavirus, please click here
Summary of Meeting:
Upon completion of this conference, participants should be able to: - Understand the activation mechanisms and functions of NF-kappaB transcription factors in various biologic contexts, including innate immunity. - Gain insight into the multiple modes of regulation that govern NF-kappaB activity, with a new emphasis on actions at the promoter/chromatin level. - Identify novel molecular targets for therapeutic intervention, particularly those potentially related to specific NF-kappaB-activation signals and/or specific NF-kappaB-controlled genes. - Examine the mechanisms by which NF-kappaB can be inappropriately activated in disease and the specific functions of NF-kappaB that can contribute to disease, such as its anti-apoptotic functions in promoting cancer. - Develop new collaborations among attendees, promoted by the mix of scientists with diverse backgrounds ranging from immunobiology and inflammatory diseases to signal transduction, chromatin regulation and cancer.
Discounted Abstract Deadline: September 17 2003
Discounted Registration Deadline: November 11 2003
We gratefully acknowledge additional support for this conference from:

Celgene Corporation
Educational grant from Lilly USA, LLCGlaxoSmithKline Research & Development, Ltd.
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA106223-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, January 11 | 3:00PM - 7:00PM
Registration
Room: Ballroom Mezzanine


Sunday, January 11 | 6:15PM - 7:15PM
Refreshments
Room: Ballroom Mezzanine


Sunday, January 11 | 7:15PM - 7:30PM
Orientation
Room: Ballroom 2-3


Sunday, January 11 | 7:30PM - 8:30PM
Keynote Address
Room: Ballroom 2-3

Speaker 1 of 1
Michael Karin, University of California, San Diego, USA
The IkB Kinase (IKK) – A Signaling Machine and its Role in Innate and Adaptive Immunity

Monday, January 12 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles Nest


Monday, January 12 | 8:00AM - 11:00AM
Structure and Regulation Session Sponsored in part by Celgen
e Signal Research Division

Room: Ballroom 2-3

Speaker 1 of 6
* David Baltimore, California Institute of Technology, USA

Monday, January 12 | 8:00AM - 11:00AM
Structure and Regulation Session Sponsored in part by Celgen
e Signal Research Division

Room: Ballroom 2-3

Speaker 2 of 6
Gourisankar Ghosh, University of California, San Diego, USA
PSO Homodimer: Generations and Ligand Binding

Monday, January 12 | 8:00AM - 11:00AM
Structure and Regulation Session Sponsored in part by Celgen
e Signal Research Division

Room: Ballroom 2-3

Speaker 3 of 6
Yinon M. Ben-Neriah, Hebrew University, Hadassah Medical School, Israel
Control of IkappaB Degradation

Monday, January 12 | 8:00AM - 11:00AM
Structure and Regulation Session Sponsored in part by Celgen
e Signal Research Division

Room: Ballroom 2-3

Speaker 4 of 6
Warner Craig Greene, Gladstone Institute of Virology and Immunology, USA
A Role for NF-kappaB/Rel Transcription Factors in Spatial Learning and Memory

Monday, January 12 | 8:00AM - 11:00AM
Structure and Regulation Session Sponsored in part by Celgen
e Signal Research Division

Room: Ballroom 2-3

Speaker 5 of 6
Lin Chen, University of Southern California, USA
Structural and Biochemical Analyses of NFAT Complexes

Monday, January 12 | 8:00AM - 11:00AM
Structure and Regulation Session Sponsored in part by Celgen
e Signal Research Division

Room: Ballroom 2-3

Speaker 6 of 6
Shigeki Miyamoto, University of Wisconsin, Madison, USA
Short Talk: NF-kappaB Activation by Genotoxic Stress Inducers

Monday, January 12 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Mezzanine


Monday, January 12 | 11:00AM - 1:00PM
Poster Setup
Room: Wasatch, Maybird, Superior


Monday, January 12 | 1:00PM - 10:00PM
Poster Viewing
Room: Wasatch, Maybird, Superior


Monday, January 12 | 2:00PM - 4:00PM
Workshop 1: Regulatory Pathways
Room: Ballroom 2-3

Speaker 1 of 6
* Jorge Moscat, Sanford Burnham Prebys Institute, USA
Control of NF-kappaB and the Immune Response by zetaPKC and its Modulators Par-4 and p62

Monday, January 12 | 2:00PM - 4:00PM
Workshop 1: Regulatory Pathways
Room: Ballroom 2-3

Speaker 2 of 6
M. Frances Shannon, Australian National University, Australia
C-Rel, T Cell Activation and Chromatin

Monday, January 12 | 2:00PM - 4:00PM
Workshop 1: Regulatory Pathways
Room: Ballroom 2-3

Speaker 3 of 6
Mark R. Boothby, Vanderbilt University Medical Center, USA
The NF-kappaB Signaling Network in T Cell Survival and Effector Function

Monday, January 12 | 2:00PM - 4:00PM
Workshop 1: Regulatory Pathways
Room: Ballroom 2-3

Speaker 4 of 6
Guido Franzoso, Imperial College London, UK
The Control of JNK Signaling and Apoptosis by NF-kappaB

Monday, January 12 | 2:00PM - 4:00PM
Workshop 1: Regulatory Pathways
Room: Ballroom 2-3

Speaker 5 of 6
Xiaoxia Li, Cleveland Clinic Foundation, USA
Act1, A Negative Regulator in CD40- and BAFF-Mediated B Cell Survival

Monday, January 12 | 2:00PM - 4:00PM
Workshop 1: Regulatory Pathways
Room: Ballroom 2-3

Speaker 6 of 6
Jun-Ichiro Inoue, University of Tokyo, Japan
Identification of TIFA as an Adapter Protein that Links TRAF6 to IRAK-1

Monday, January 12 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Ballroom Mezzanine


Monday, January 12 | 5:00PM - 7:00PM
New Functions for NF-kappaB and NFAT
Room: Ballroom 2-3

Speaker 1 of 4
* Sankar Ghosh, Columbia University, USA

Monday, January 12 | 5:00PM - 7:00PM
New Functions for NF-kappaB and NFAT
Room: Ballroom 2-3

Speaker 2 of 4
David Baltimore, California Institute of Technology, USA
NF-KappaB in Neurons

Monday, January 12 | 5:00PM - 7:00PM
New Functions for NF-kappaB and NFAT
Room: Ballroom 2-3

Speaker 3 of 4
Inder M. Verma, The Salk Institute, USA
Regulation of NF-kappaB Activity

Monday, January 12 | 5:00PM - 7:00PM
New Functions for NF-kappaB and NFAT
Room: Ballroom 2-3

Speaker 4 of 4
Anjana Rao, La Jolla Institute for Allergy and Immunology, USA
NFAT, a Family of Transcription Factors Related to Rel/ NFkappaB

Monday, January 12 | 7:00PM - 8:00PM
Social Hour
Room: Wasatch, Maybird, Superior


Monday, January 12 | 7:30PM - 10:00PM
Poster Session 1
Room: Wasatch, Maybird, Superior


Tuesday, January 13 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles Nest


Tuesday, January 13 | 8:00AM - 11:00AM
Immunology
Room: Ballroom 2-3

Speaker 1 of 7
* Alain Israël, Institut Pasteur, France

Tuesday, January 13 | 8:00AM - 11:00AM
Immunology
Room: Ballroom 2-3

Speaker 2 of 7
Klaus Rajewsky, Max Delbrück Center for Molecular Medicine, Germany
and

Tuesday, January 13 | 8:00AM - 11:00AM
Immunology
Room: Ballroom 2-3

Speaker 3 of 7
Marc Schmidt-Supprian, Max Planck Institute of Biochemistry, Germany
IKK Signaling in Lymphocyte Differentiation and Homeostasis

Tuesday, January 13 | 8:00AM - 11:00AM
Immunology
Room: Ballroom 2-3

Speaker 4 of 7
Ulrich K. Siebenlist, NIAID, National Institutes of Health, USA
Regulatory Pathways of NF-kappaB in Biologic Context

Tuesday, January 13 | 8:00AM - 11:00AM
Immunology
Room: Ballroom 2-3

Speaker 5 of 7
Steve D. Gerondakis, Monash University, Australia
Rel/NF-kappaB and Call Activation in the Immune System

Tuesday, January 13 | 8:00AM - 11:00AM
Immunology
Room: Ballroom 2-3

Speaker 6 of 7
Hsiou-Chi Liou, Weill Medical College of Cornell University, USA
C-Rel in Antigen Receptor-Mediated Lymphocyte Activation and Selection

Tuesday, January 13 | 8:00AM - 11:00AM
Immunology
Room: Ballroom 2-3

Speaker 7 of 7
Céline Gélinas, Center for Advanced Biotechnology and Medicine, USA
Insights into Rel/NF-kappaB Function in the Oncogenic Transformation of Lymphocytes

Tuesday, January 13 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Mezzanine


Tuesday, January 13 | 11:00AM - 1:00PM
Poster Setup
Room: Wasatch, Maybird, Superior


Tuesday, January 13 | 1:00PM - 10:00PM
Poster Viewing
Room: Wasatch, Maybird, Superior


Tuesday, January 13 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Ballroom Mezzanine


Tuesday, January 13 | 5:00PM - 7:00PM
Innate Immunity
Room: Ballroom 2-3

Speaker 1 of 4
* Klaus Rajewsky, Max Delbrück Center for Molecular Medicine, Germany

Tuesday, January 13 | 5:00PM - 7:00PM
Innate Immunity
Room: Ballroom 2-3

Speaker 2 of 4
Akira Shizuo, Osaka University, Japan
Toll-Like Receptor Signaling

Tuesday, January 13 | 5:00PM - 7:00PM
Innate Immunity
Room: Ballroom 2-3

Speaker 3 of 4
Gabriel Nuñez, University of Michigan, USA
NODs: Cytosolic Proteins Involved in Innate Immunity and Inflammatory Disease

Tuesday, January 13 | 5:00PM - 7:00PM
Innate Immunity
Room: Ballroom 2-3

Speaker 4 of 4
Zhijian 'James' Chen, University of Texas Southwestern Medical Center, USA
Ubiquitin Signaling in the NF-kappaB Pathway

Tuesday, January 13 | 7:00PM - 8:00PM
Social Hour
Room: Wasatch, Maybird, Superior


Tuesday, January 13 | 7:30PM - 10:00PM
Poster Session 2
Room: Wasatch, Maybird, Superior


Wednesday, January 14 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles Nest


Wednesday, January 14 | 8:00AM - 11:30AM
Chromatin, Targets and Pathology
Room: Ballroom 2-3

Speaker 1 of 8
* Inder M. Verma, The Salk Institute, USA

Wednesday, January 14 | 8:00AM - 11:30AM
Chromatin, Targets and Pathology
Room: Ballroom 2-3

Speaker 2 of 8
* Michael Karin, University of California, San Diego, USA

Wednesday, January 14 | 8:00AM - 11:30AM
Chromatin, Targets and Pathology
Room: Ballroom 2-3

Speaker 3 of 8
Sankar Ghosh, Columbia University, USA
Regulation of NF-kappaB Transcriptional Activity

Wednesday, January 14 | 8:00AM - 11:30AM
Chromatin, Targets and Pathology
Room: Ballroom 2-3

Speaker 4 of 8
Albert S. Baldwin Jr., University of North Carolina School of Medicine, USA
Regulation of NF-kappaB Function by the IKKs and Other Signal Transduction Pathways

Wednesday, January 14 | 8:00AM - 11:30AM
Chromatin, Targets and Pathology
Room: Ballroom 2-3

Speaker 5 of 8
Shao-Cong Sun, University of Texas MD Anderson Cancer Center, USA
Novel Signaling Functions of NF-kappaB and IKK

Wednesday, January 14 | 8:00AM - 11:30AM
Chromatin, Targets and Pathology
Room: Ballroom 2-3

Speaker 6 of 8
Gioacchino Natoli, Humanitas University, Italy
An Essential Contribution of p65 Degradation to NF-kappaB Response Termination

Wednesday, January 14 | 8:00AM - 11:30AM
Chromatin, Targets and Pathology
Room: Ballroom 2-3

Speaker 7 of 8
Gail E. Sonenshein, Boston University Medical School, USA
Roles and Regulation of NF-kappaB/Rel in Breast Cancer

Wednesday, January 14 | 8:00AM - 11:30AM
Chromatin, Targets and Pathology
Room: Ballroom 2-3

Speaker 8 of 8
Gary J. Nabel, Sanofi, USA
Murr1 Inhibits NF-kappaB Activation and Restricts HIV Replication in Resting and Activated T Cells through its Effects on the Proteasome

Wednesday, January 14 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Mezzanine


Wednesday, January 14 | 11:30AM - 1:00PM
Poster Setup
Room: Wasatch, Maybird, Superior


Wednesday, January 14 | 1:00PM - 10:00PM
Poster Viewing
Room: Wasatch, Maybird, Superior


Wednesday, January 14 | 2:00PM - 4:00PM
Workshop 2: Pathology to Clinic
Room: Ballroom 2-3

Speaker 1 of 6
* Thomas D. Gilmore, Boston University, USA
The REL Transcription Factor as a Molecular Target in Human Lymphoma

Wednesday, January 14 | 2:00PM - 4:00PM
Workshop 2: Pathology to Clinic
Room: Ballroom 2-3

Speaker 2 of 6
Guy Haegeman, Ghent University, Belgium
Repression of Inflammatory Gene Expression by Phyto-Estrogen

Wednesday, January 14 | 2:00PM - 4:00PM
Workshop 2: Pathology to Clinic
Room: Ballroom 2-3

Speaker 3 of 6
Towia A. Libermann, Beth Israel Deaconess Medical Center, USA
New Insights into the Anti-Apoptotic Function of NF-kappaB in Cancer Cells

Wednesday, January 14 | 2:00PM - 4:00PM
Workshop 2: Pathology to Clinic
Room: Ballroom 2-3

Speaker 4 of 6
Vincent M. Bours, University of Liege, Belgium
Regulation of Bcl-3 Oncogenic Potential by Phosphorylation

Wednesday, January 14 | 2:00PM - 4:00PM
Workshop 2: Pathology to Clinic
Room: Ballroom 2-3

Speaker 5 of 6
Bruce H. Horwitz, Brigham and Women's Hospital, USA
Inhibition of Pathological Inflammatory Responses by NF-kappaB Subunits p50 and p65

Wednesday, January 14 | 2:00PM - 4:00PM
Workshop 2: Pathology to Clinic
Room: Ballroom 2-3

Speaker 6 of 6
Neil D. Perkins, University of Newcastle, UK
Repression of Anti-Apoptotic Gene Expression by RelA(p65) NF-kappaB

Wednesday, January 14 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Ballroom Mezzanine


Wednesday, January 14 | 5:00PM - 7:00PM
Model Organisms
Room: Ballroom 2-3

Speaker 1 of 4
* Ulrich K. Siebenlist, NIAID, National Institutes of Health, USA

Wednesday, January 14 | 5:00PM - 7:00PM
Model Organisms
Room: Ballroom 2-3

Speaker 2 of 4
Ruth Steward, Rutgers University, USA
NF-kappaB/Rel Pathways in Drosophila.

Wednesday, January 14 | 5:00PM - 7:00PM
Model Organisms
Room: Ballroom 2-3

Speaker 3 of 4
Dominique Ferrandon, Institute of Cellular and Molecular Biology, France
Activation of NF-kappaB Members in Drosophila Immunity

Wednesday, January 14 | 5:00PM - 7:00PM
Model Organisms
Room: Ballroom 2-3

Speaker 4 of 4
Steven A. Wasserman, University of California, San Diego, USA
Toll Signaling in Drosophila

Wednesday, January 14 | 7:00PM - 8:00PM
Social Hour
Room: Wasatch, Maybird, Superior


Wednesday, January 14 | 7:30PM - 10:00PM
Poster Session 3
Room: Wasatch, Maybird, Superior


Thursday, January 15 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles Nest


Thursday, January 15 | 8:00AM - 11:30AM
Pathology
Room: Ballroom 2-3

Speaker 1 of 7
* Anjana Rao, La Jolla Institute for Allergy and Immunology, USA

Thursday, January 15 | 8:00AM - 11:30AM
Pathology
Room: Ballroom 2-3

Speaker 2 of 7
Alain Israël, Institut Pasteur, France
Biochemical and Genetic Analysis of the NF-kappaB Signaling Pathway

Thursday, January 15 | 8:00AM - 11:30AM
Pathology
Room: Ballroom 2-3

Speaker 3 of 7
Claus Scheidereit, Max Delbrück Center for Molecular Medicine, Germany
Activation and Homeostatic Control of IKK and NF-kappaB in Oncogenesis and Innate Immunity

Thursday, January 15 | 8:00AM - 11:30AM
Pathology
Room: Ballroom 2-3

Speaker 4 of 7
Alexander Hoffmann, University of California, Los Angeles, USA
Mechanisms that Generate Stimulus Specificity in the NF-kappaB Pathway

Thursday, January 15 | 8:00AM - 11:30AM
Pathology
Room: Ballroom 2-3

Speaker 5 of 7
Elliott D. Kieff, Harvard University, USA
Role of TRAF6 and IRAK1 in LMP1 Induced NF-kappaB Activation

Thursday, January 15 | 8:00AM - 11:30AM
Pathology
Room: Ballroom 2-3

Speaker 6 of 7
George Mosialos, B.S.R.C. Alexander Fleming, Greece
Short Talk: Regulation of NF-kappaB by the Cylindromatosis Tumor Suppressor Gene Product

Thursday, January 15 | 8:00AM - 11:30AM
Pathology
Room: Ballroom 2-3

Speaker 7 of 7
Manolis Pasparakis, University of Cologne, Germany
Short Talk: Analysis of the Function of IKK2 and NEMO in Adult Mice by Conditional Targeting

Thursday, January 15 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Mezzanine


Thursday, January 15 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Ballroom Mezzanine


Thursday, January 15 | 5:00PM - 7:00PM
Pathology to Clinic. Session Sponsored in part by GlaxoSmit
hKline Research & Development Ltd.

Room: Ballroom 2-3

Speaker 1 of 5
* Albert S. Baldwin Jr., University of North Carolina School of Medicine, USA

Thursday, January 15 | 5:00PM - 7:00PM
Pathology to Clinic. Session Sponsored in part by GlaxoSmit
hKline Research & Development Ltd.

Room: Ballroom 2-3

Speaker 2 of 5
Louis M. Staudt, NCI, National Institutes of Health, USA
NF-kappaB as a Therapeutic Target in Lymphoma

Thursday, January 15 | 5:00PM - 7:00PM
Pathology to Clinic. Session Sponsored in part by GlaxoSmit
hKline Research & Development Ltd.

Room: Ballroom 2-3

Speaker 3 of 5
Steven E. Shoelson, Harvard Medical School, Joslin Diabetes Center, USA
Tissue-Specific Roles for IKKb/NF-kappaB in Insulin Resistance and Muscle Wasting

Thursday, January 15 | 5:00PM - 7:00PM
Pathology to Clinic. Session Sponsored in part by GlaxoSmit
hKline Research & Development Ltd.

Room: Ballroom 2-3

Speaker 4 of 5
Frank Mercurio, BioTheryX, Inc., USA
IKK-Related Kinase as a Target for Drug Therapy

Thursday, January 15 | 5:00PM - 7:00PM
Pathology to Clinic. Session Sponsored in part by GlaxoSmit
hKline Research & Development Ltd.

Room: Ballroom 2-3

Speaker 5 of 5
Carter Van Waes, NIDCD, National Institutes of Health, USA
NF-kappaB and Proteasome Inhibition in Therapy of Head and Neck Cancer

Thursday, January 15 | 7:00PM - 8:00PM
Social Hour
Room: Ballroom I/Lobby/Mezzanine I & II


Thursday, January 15 | 8:00PM - 11:00PM
Entertainment
Room: Ballroom I/Lobby/Mezzanine I & II


Thursday, January 15 | 8:00PM - 11:00PM
Cash Bar
Room: Ballroom I/Lobby/Mezzanine I & II


Friday, January 16 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.