Web Desc
Angiogenesis: Novel Basic Science Insights and Human Therapy
Organizer(s): Napoleone Ferrara, Shahin Rafii and Elisabetta Dejana
Date: January 13 - 18, 2004
Location: Eldorado Hotel & Spa, Santa Fe, NM, USA
Sponsored by Abbott Laboratories and Berlex Biosciences
Summary of Meeting:
The establishment of a blood supply has been long known to be of fundamental importance for embryonic development, reproductive functions, tumorigenesis and many other proliferative processes. Over the last decade, major progress has been made in the identification of some key angiogenic inducers and several anti-angiogenic molecules. Substantial advances have been also made in the understanding of the regulation of angiogenesis by oxygen tension and other mechanisms. However, many important questions are still unanswered. For example, the traditional concept that angiogenesis occurs by sprouting of resident endothelial cells has been complemented by the finding that bone marrow-derived progenitor cells can be incorporated in the vessels, but the contribution of these elements in various pathophysiologic situations remains to be determined. Also, the identification of at least one tissue-specific angiogenic factor suggests a greater level of complexity and specialization than previously appreciated. An issue intensely debated in the field is the interplay and cooperation among soluble factors and extracellular matrix proteins to achieve not only morphogenesis but also diversity among blood vessels in different organs. In addition, clinical testing of angiogenesis inducers and inhibitors is in advanced stage and results of some pivotal trials will be known by the time the meeting takes place. The objective of this meeting is to discuss the latest basic science findings and review the status of the clinical application of angiogenic growth factors and inhibitors; learn the latest molecular and genetic findings on the regulation of angiogenesis; acquire an integrated view of the role of blood vessels in health and disease; discuss the results of then initial pivotal clinical trials in angiogenesis and anti-angiogenesis; and identify the pathological conditions that are most likely to benefit from such treatments.
Discounted Abstract Deadline: September 22 2003
Discounted Registration Deadline: November 13 2003
We gratefully acknowledge additional support for this conference from:

Abbott Laboratories
American Heart AssociationBerlex BiosciencesGenentech, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA105865-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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Program

Tuesday, January 13 | 3:00PM - 7:00PM
Registration
Room: Foyer


Tuesday, January 13 | 6:15PM - 7:15PM
Refreshments
Room: Court


Tuesday, January 13 | 7:15PM - 7:30PM
Orientation
Room: Ballroom


Tuesday, January 13 | 7:30PM - 9:30PM
Keynote Session
Room: Ballroom

Speaker 1 of 2
Kari K. Alitalo, University of Helsinki, Finland
Lymphangiogenesis: Insights to Lymphedema and Lymphatic Metastasis

Tuesday, January 13 | 7:30PM - 9:30PM
Keynote Session
Room: Ballroom

Speaker 2 of 2
William G. Kaelin, Jr., Dana-Farber Cancer Institute, USA
Molecular Pathogenesis of the Von Hippel-Lindau Hereditary Cancer Syndrome

Wednesday, January 14 | 7:00AM - 8:00AM
Breakfast
Room: Court


Wednesday, January 14 | 8:00AM - 11:00AM
Developmental Aspects of Angiogenesis
Room: Ballroom

Speaker 1 of 5
* Peter F. Carmeliet, University of Leuven, VIB, Belgium
Novel Functions of VEGF


Wednesday, January 14 | 8:00AM - 11:00AM
Developmental Aspects of Angiogenesis
Room: Ballroom

Speaker 2 of 5
Barbara L. Hempstead, Weil Cornell Medical College, USA
Angiogenic Actions of BDNF

Wednesday, January 14 | 8:00AM - 11:00AM
Developmental Aspects of Angiogenesis
Room: Ballroom

Speaker 3 of 5
Anne C. Eichmann, Yale University School of Medicine, USA
Neural Receptors in Vascular Development

Wednesday, January 14 | 8:00AM - 11:00AM
Developmental Aspects of Angiogenesis
Room: Ballroom

Speaker 4 of 5
David J. Anderson, California Institute of Technology, USA
Neuroangiogenesis and the Control of Vessel Identity

Wednesday, January 14 | 8:00AM - 11:00AM
Developmental Aspects of Angiogenesis
Room: Ballroom

Speaker 5 of 5
Rong Wang, University of California, San Francisco, USA
Short Talk: Tie2-Cre-Mediated Deletion of fak Disrupts Sprouting and Intussuscepting Angiogenesis

Wednesday, January 14 | 9:20AM - 9:40AM
Coffee Break
Room: Court


Wednesday, January 14 | 11:00AM - 1:00PM
Poster Setup
Room: Sunset/Court


Wednesday, January 14 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunset/Court


Wednesday, January 14 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Court


Wednesday, January 14 | 5:00PM - 7:15PM
Assembly of the Vessel Wall
Room: Ballroom

Speaker 1 of 5
* Elisabetta Dejana, Uppsala University, Sweden
Intercellular Junctions and Endothelial Cell-to-Cell Signaling in Angiogenesis

Wednesday, January 14 | 5:00PM - 7:15PM
Assembly of the Vessel Wall
Room: Ballroom

Speaker 2 of 5
Gavin O. Thurston, Regeneron Pharmaceuticals Inc., USA
Collaborative Actions of VEGFs and Angiopoietins during Normal and Pathologic Angiogenesis, and Anti-tumor Actions of the VEGF Trap

Wednesday, January 14 | 5:00PM - 7:15PM
Assembly of the Vessel Wall
Room: Ballroom

Speaker 3 of 5
Christer Betsholtz, Uppsala University, Sweden
VEGF/PDGF Gradients and Vascular Morphogenesis

Wednesday, January 14 | 5:00PM - 7:15PM
Assembly of the Vessel Wall
Room: Ballroom

Speaker 4 of 5
Ricky Tong, Massachusetts General Hospital, USA
Short Talk: Dynamics of Vessel Normalization following VEGF Blockade

Wednesday, January 14 | 5:00PM - 7:15PM
Assembly of the Vessel Wall
Room: Ballroom

Speaker 5 of 5
Yasuhiro Ito, Kumamoto University, Japan
Short Talk: Angiopoietin-Related Protein 2 (ARP2) Promotes Angiogenesis but not Vascular Leakage

Wednesday, January 14 | 7:15PM - 8:15PM
Social Hour
Room: Sunset/Court


Wednesday, January 14 | 7:30PM - 10:00PM
Poster Session 1
Room: Sunset/Court


Thursday, January 15 | 7:00AM - 8:00AM
Breakfast
Room: Court


Thursday, January 15 | 8:00AM - 11:15AM
Signaling Pathways in Angiogenesis
Room: Ballroom

Speaker 1 of 6
* Masabumi Shibuya, University of Tokyo, Japan
VEGF Receptor Signaling Toward Cell Growth and Survival

Thursday, January 15 | 8:00AM - 11:15AM
Signaling Pathways in Angiogenesis
Room: Ballroom

Speaker 2 of 6
Carl-Henrik Heldin, Ludwig Institute for Cancer Research, Sweden
Use of PDGF Antagonists in Tumor Treatment

Thursday, January 15 | 8:00AM - 11:15AM
Signaling Pathways in Angiogenesis
Room: Ballroom

Speaker 3 of 6
Jacques Pouysségur, University of Nice, France
Hypoxia Signaling and Angiogenesis

Thursday, January 15 | 8:00AM - 11:15AM
Signaling Pathways in Angiogenesis
Room: Ballroom

Speaker 4 of 6
David A. Cheresh, University of California, San Diego, USA
Unexpected Role of VEGF in Ischemic Disease and Cancer

Thursday, January 15 | 8:00AM - 11:15AM
Signaling Pathways in Angiogenesis
Room: Ballroom

Speaker 5 of 6
David Lyden, Weill Cornell Medical College, USA
Short Talk: Recruitment of VEGFR1+ Hematopoietic Progenitors Contributes to the Establishment of Tumor Metastasis

Thursday, January 15 | 8:00AM - 11:15AM
Signaling Pathways in Angiogenesis
Room: Ballroom

Speaker 6 of 6
Steve Suchting, University of Oxford, UK
Short Talk: Robo4 is an Endothelial Specific Roundabout Receptor involved in Endothelial Cell Migration and Angiogenesis

Thursday, January 15 | 9:20AM - 9:40AM
Coffee Break
Room: Court


Thursday, January 15 | 11:15AM - 1:00PM
Poster Setup
Room: Sunset/Court


Thursday, January 15 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunset/Court


Thursday, January 15 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Court


Thursday, January 15 | 5:00PM - 7:15PM
Pathological Angiogenesis
Room: Ballroom

Speaker 1 of 4
* M. Judah Folkman, Children's Hospital Boston, USA
Can the Switch to the Angiogenic Phenotype be Prevented in Human Cancer?

Thursday, January 15 | 5:00PM - 7:15PM
Pathological Angiogenesis
Room: Ballroom

Speaker 2 of 4
Robert S. Kerbel, Sunnybrook Research Institute, Canada
Molecular and Cellular Basis for the Antiangiogenic Effects of Low Dose Metronomic Chemotherapy

Thursday, January 15 | 5:00PM - 7:15PM
Pathological Angiogenesis
Room: Ballroom

Speaker 3 of 4
Michael J. Detmar, ETH - Zürich, Switzerland
Tumor Lymphangiogenesis

Thursday, January 15 | 5:00PM - 7:15PM
Pathological Angiogenesis
Room: Ballroom

Speaker 4 of 4
Hellmut G. Augustin, DKFZ & Heidelberg University, Germany
Role of EphB/ephrinB Interactions during Vascular Homeostasis and Tumor Angiogenesis

Thursday, January 15 | 7:15PM - 8:15PM
Social Hour
Room: Sunset/Court


Thursday, January 15 | 7:30PM - 10:00PM
Poster Session 2
Room: Sunset/Court


Friday, January 16 | 7:00AM - 8:00AM
Breakfast
Room: Court


Friday, January 16 | 8:00AM - 11:15AM
Microenvironment and Novel Roles of the Endothelium
Room: Ballroom

Speaker 1 of 5
* Rakesh K. Jain, Massachusetts General Hospital and Harvard Medical School, USA
Angiogenesis and Lymphangiogenesis: Insights from Intravital Microscopy

Friday, January 16 | 8:00AM - 11:15AM
Microenvironment and Novel Roles of the Endothelium
Room: Ballroom

Speaker 2 of 5
Gabriele A.I. Bergers, University of Leuven, Belgium
The Microenvironment Matters: Dual Role of HIF-1a

Friday, January 16 | 8:00AM - 11:15AM
Microenvironment and Novel Roles of the Endothelium
Room: Ballroom

Speaker 3 of 5
Napoleone Ferrara, University of California, San Diego, USA
Novel Insights in the Role of VEGF and other Mediators in Endothelial Diversity

Friday, January 16 | 8:00AM - 11:15AM
Microenvironment and Novel Roles of the Endothelium
Room: Ballroom

Speaker 4 of 5
Thiennu H. Vu, University of California, San Francisco, USA
The Role of VEGF-A in Lung Development

Friday, January 16 | 8:00AM - 11:15AM
Microenvironment and Novel Roles of the Endothelium
Room: Ballroom

Speaker 5 of 5
Masataka Majima, Kitasato University School of Medicine, Japan
Short Talk: Host Stromal Prostaglandin E2-EP3 Signaling Facillitates Tumor-Associated Angiogenesis and Tumor Growth

Friday, January 16 | 9:20AM - 9:40AM
Coffee Break
Room: Court


Friday, January 16 | 11:15AM - 1:00PM
Poster Setup
Room: Sunset/Court


Friday, January 16 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunset/Court


Friday, January 16 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Court


Friday, January 16 | 5:00PM - 7:00PM
Endothelial Progenitor and Therapeutic Aspects of Angiogenes
is

Room: Ballroom

Speaker 1 of 4
* Shahin Rafii, Weill Cornell Medical College, USA
Co-Recruitment of Vascular and Angio-Competent Hematopoietic Progenitor Cells Contributes to Angiogenesis

Friday, January 16 | 5:00PM - 7:00PM
Endothelial Progenitor and Therapeutic Aspects of Angiogenes
is

Room: Ballroom

Speaker 2 of 4
Eli Keshet, Hebrew University, Israel
Conditional Organ-Specific Induction of Vegf: Insights into Adult Neovascularization and Pro-Angiogenic Therapy

Friday, January 16 | 5:00PM - 7:00PM
Endothelial Progenitor and Therapeutic Aspects of Angiogenes
is

Room: Ballroom

Speaker 3 of 4
Ellen H. Filvaroff, Genentech, Inc., USA
Short Talk: VEGF Stimulates Bone Repair by Acting on Endothelial and Bone Cells

Friday, January 16 | 5:00PM - 7:00PM
Endothelial Progenitor and Therapeutic Aspects of Angiogenes
is

Room: Ballroom

Speaker 4 of 4
Stéphane E. Germain, INSERM, France
Short Talk: Hypoxia-Induced Gene Expression in Endothelial Cells: Identification of Angiopoietin-Like 4

Friday, January 16 | 7:00PM - 8:00PM
Social Hour
Room: Sunset/Court


Friday, January 16 | 7:30PM - 10:00PM
Poster Session 3
Room: Sunset/Court


Saturday, January 17 | 7:00AM - 8:00AM
Breakfast
Room: Court


Saturday, January 17 | 8:00AM - 11:00AM
Extracellular Matrix and Angiogenesis
Room: Ballroom

Speaker 1 of 5
* Luisa Iruela-Arispe, University of California, Los Angeles, USA
Interplay Between Matrix Metalloproteases and VEGF in the Context of Tumors


Saturday, January 17 | 8:00AM - 11:00AM
Extracellular Matrix and Angiogenesis
Room: Ballroom

Speaker 2 of 5
Raghu Kalluri, University of Texas MD Anderson Cancer Center, USA
ECM Degradome Contributes to Novel Class of Tumor Supressors

Saturday, January 17 | 8:00AM - 11:00AM
Extracellular Matrix and Angiogenesis
Room: Ballroom

Speaker 3 of 5
Judith A. Varner, University of California, San Diego, USA
Integrin a4b1 Mediates Endothelial Stem Cell Trafficking during Neovascularization

Saturday, January 17 | 8:00AM - 11:00AM
Extracellular Matrix and Angiogenesis
Room: Ballroom

Speaker 4 of 5
Jean Plouet, Hopital Lariboisiere, France
VEGF-Driven Arterialization: A New Approach for Therapy

Saturday, January 17 | 8:00AM - 11:00AM
Extracellular Matrix and Angiogenesis
Room: Ballroom

Speaker 5 of 5
Shoukat Dedhar, British Columbia Cancer Research Centre, Canada
Short Talk: An Essential Role of Integrin-Linked Kinase(ILK) in Tumor Angiogenesis

Saturday, January 17 | 9:20AM - 9:40AM
Coffee Break
Room: Court


Saturday, January 17 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Court


Saturday, January 17 | 5:00PM - 7:15PM
Clinical Trials
Room: Ballroom

Speaker 1 of 4
* William Novotny, Genentech, Inc., USA
Clinical Development of Bevacizumab (AvastinTM, a Monoclonal Antibody to Vascular Endothelial Growth Factor) in Colorectal Cancer and Other Solid Tumors

Saturday, January 17 | 5:00PM - 7:15PM
Clinical Trials
Room: Ballroom

Speaker 2 of 4
David T. Shima, University College London, UK
VEGF Inhibition in Age-Related Macular Degeneration: Phase 2/3 Pegaptanib (Macugen™) Results

Saturday, January 17 | 5:00PM - 7:15PM
Clinical Trials
Room: Ballroom

Speaker 3 of 4
Dieter Marmé, Tumor Biology Center Freiburg, Germany
The Development of Small Molecule VEGF Receptor Inhibitors

Saturday, January 17 | 5:00PM - 7:15PM
Clinical Trials
Room: Ballroom

Speaker 4 of 4
J. Anthony Ware, Eli Lilly and Company, USA
Overview of Therapeutic Angiogenesis Clinical Trials

Saturday, January 17 | 7:15PM - 8:15PM
Social Hour
Room: Sunset/Court


Saturday, January 17 | 8:00PM - 11:00PM
Entertainment
Room: Sunset/Court


Saturday, January 17 | 8:15PM - 11:00PM
Cash Bar
Room: Sunset/Court


Sunday, January 18 | 10:26AM - 10:26AM
Departure


*Session Chair.