Web Desc
Emerging Mechanisms of Epigenetic Regulation
Organizer(s): Jeannie T. Lee and Vicki L. Chandler
Date: January 21 - 26, 2004
Location: Granlibakken Tahoe, Tahoe City, CA, USA
Sponsored in part by the Director's Sponsor Fund
Summary of Meeting:
EXECUTIVE SUMMARY: Epigenetics is an exciting and very rapidly moving field that impacts basic science, clinical medicine and agriculture. While an understanding of underlying processes is just beginning to emerge, basic questions about how epigenetic processes work and whether diverse processes share underlying mechanisms remain mysterious. This conference will attempt to find common themes and differences among epigenetic phenomena across all phyla (yeast, plants, animals). The meeting will emphasize the diversity of the phenomena and emerging paradigms for their control. As is becoming increasingly clear, overtly different processes find surprisingly similar strategies of regulation. Emphasis will also be placed on how epigenetic mechanisms affect clinical and agricultural interests. Upon completion of this conference, participants should be able to: - Recognize epigenetic processes across various taxa (plants, animals, yeast), including imprinting, allelic exclusion, transvection, cosuppression, quelling, and RIP/MIP. - Appreciate that these mechanisms may have evolved to regulate gene dosage, to maintain genome integrity, to defend against viruses and transposons. - Idenfity potential mediators of epigenetic phenomena such as RNA, DNA methylation, and chromatin modifiers. - Begin to recognize possible mechanistic links among diverse species and processes. - Understand how anomalies in epigenetic processes can lead to disease or and how therapeutic strategies might be design. - Emphasis is placed on imprinting disorders, genome integrity, animal cloning, cancer, and prions. - Appreciate the agricultural implications of epigenetics, such as those relating to plant viral defense mechanisms, animal cloning, and imprinting.
Discounted Abstract Deadline: September 22 2003
Discounted Registration Deadline: November 21 2003
We gratefully acknowledge additional support for this conference from:
ImprovisionMarch of Dimes FoundationNovartis Institutes for BioMedical Research
We gratefully acknowledge the generous grant for this conference provided by:

National Science Foundation (NSF)
Grant No. MCB-0353041
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Wednesday, January 21 | 3:00PM - 7:00PM
Registration
Room: Pre-Function


Wednesday, January 21 | 7:15PM - 7:30PM
Orientation
Room: Mountain/Lake Rooms


Wednesday, January 21 | 7:30PM - 8:30PM
Keynote Address
Room: Mountain/Lake Rooms

Speaker 1 of 1
Rudolf Jaenisch, Whitehead Institute for Biomedical Research, USA
Nuclear Cloning, Stem Cells and the Reprogramming of the Genome

Thursday, January 22 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Thursday, January 22 | 8:00AM - 11:00AM
Allelic Exclusion
Room: Mountain/Lake Rooms

Speaker 1 of 7
Wolf Reik, Babraham Institute, UK
Mechanisms of Imprinting and Epigenetic Reprogramming

Thursday, January 22 | 8:00AM - 11:00AM
Allelic Exclusion
Room: Mountain/Lake Rooms

Speaker 2 of 7
* Huntington F. Willard, Duke University, USA
X-Chromosome Inactivation in Mammals


Thursday, January 22 | 8:00AM - 11:00AM
Allelic Exclusion
Room: Mountain/Lake Rooms

Speaker 3 of 7
Khanh Duc Huynh, Cell Signaling Technology, USA
Short Talk: Dosage Compensation is Established from the Time of Conception in Mice

Thursday, January 22 | 8:00AM - 11:00AM
Allelic Exclusion
Room: Mountain/Lake Rooms

Speaker 4 of 7
Edith Heard, European Molecular Biology Laboratory, Germany
Short Talk: Epigenetic Dynamics of X-Chromosome Inactivation during Pre-Implantation Development of the Mouse

Thursday, January 22 | 8:00AM - 11:00AM
Allelic Exclusion
Room: Mountain/Lake Rooms

Speaker 5 of 7
Frank G. Grosveld, Erasmus University, Netherlands
Dynamics of the Globin Gene Compartment

Thursday, January 22 | 8:00AM - 11:00AM
Allelic Exclusion
Room: Mountain/Lake Rooms

Speaker 6 of 7
Ben Shykind, Columbia University, College of Physicians and Surgeons, USA
Odorant Receptor Expression: One Neuron One Allele

Thursday, January 22 | 8:00AM - 11:00AM
Allelic Exclusion
Room: Mountain/Lake Rooms

Speaker 7 of 7
Shou Serizawa, University of Tokyo, Japan
Short Talk: Negative Feedback Regulation Ensures One Receptor – One Olfactory Neuron Rule

Thursday, January 22 | 9:20AM - 9:40AM
Coffee Break
Room: Pre-Function


Thursday, January 22 | 11:00AM - 1:00PM
Poster Setup
Room: Bay Room


Thursday, January 22 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay Room


Thursday, January 22 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Pre-Function


Thursday, January 22 | 5:00PM - 7:15PM
Genomic Imprinting
Room: Mountain/Lake Rooms

Speaker 1 of 6
Alexander A. Gimelbrant, Dana-Farber Cancer Institute, USA
Short Talk: Asynchronous Replication and Monoallelic Expression in Mouse

Thursday, January 22 | 5:00PM - 7:15PM
Genomic Imprinting
Room: Mountain/Lake Rooms

Speaker 2 of 6
Ueli Grossniklaus, University of Zürich, Switzerland
Genomic Imprinting during Seed Development in Arabidopsis thaliana

Thursday, January 22 | 5:00PM - 7:15PM
Genomic Imprinting
Room: Mountain/Lake Rooms

Speaker 3 of 6
Nora I. Engel, Temple University School of Medicine, USA
Regulation of Imprinting at the H19/Igf2 Locus

Thursday, January 22 | 5:00PM - 7:15PM
Genomic Imprinting
Room: Mountain/Lake Rooms

Speaker 4 of 6
Anne C. Ferguson-Smith, University of Cambridge, UK
Short Talk: Epigenetic Control at the Dlk1-Gtl2 Imprinted Domain on Mouse Distal Chromosome 12

Thursday, January 22 | 5:00PM - 7:15PM
Genomic Imprinting
Room: Mountain/Lake Rooms

Speaker 5 of 6
Christine M. Williamson, Medical Research Council, UK
Short Talk: Identification of an Imprinting Control Region and a Role for the Non-Coding Antisense, Nespas in the Gnas Imprinting Cluster

Thursday, January 22 | 5:00PM - 7:15PM
Genomic Imprinting
Room: Mountain/Lake Rooms

Speaker 6 of 6
* Denise P. Barlow, Center for Molecular Medicine, Austria
A Role for Non-Coding RNAs in Genomic Imprinting

Thursday, January 22 | 7:15PM - 8:15PM
Dinner
Room: Granhall


Thursday, January 22 | 8:00PM - 10:30PM
Poster Session 1
Room: Bay Room


Thursday, January 22 | 8:15PM - 9:15PM
Social Hour
Room: Bay Room


Friday, January 23 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Friday, January 23 | 8:00AM - 11:00AM
Unusual Epigenetic Phenomena
Room: Mountain/Lake Rooms

Speaker 1 of 6
* Carmen Sapienza, Temple University, USA
The Things that Happen between Males and Females: Lessons Learned from the DDK Mouse

Friday, January 23 | 8:00AM - 11:00AM
Unusual Epigenetic Phenomena
Room: Mountain/Lake Rooms

Speaker 2 of 6
Eric U. Selker, University of Oregon, USA
Genome Defense and DNA Methylation In Neurospora

Friday, January 23 | 8:00AM - 11:00AM
Unusual Epigenetic Phenomena
Room: Mountain/Lake Rooms

Speaker 3 of 6
Ting (C.-ting) Wu, Harvard Medical School, USA
Transvection: Dating at the Genome Level

Friday, January 23 | 8:00AM - 11:00AM
Unusual Epigenetic Phenomena
Room: Mountain/Lake Rooms

Speaker 4 of 6
Vicki L. Chandler, Minerva Schools at Keck Graduate Institute, USA
Paramutation in Maize

Friday, January 23 | 8:00AM - 11:00AM
Unusual Epigenetic Phenomena
Room: Mountain/Lake Rooms

Speaker 5 of 6
Paul D. Soloway, Cornell University, USA
Short Talk: Paramutation and Trans-Allele Methylation in Mice

Friday, January 23 | 8:00AM - 11:00AM
Unusual Epigenetic Phenomena
Room: Mountain/Lake Rooms

Speaker 6 of 6
B. Tibor Roberts, NIDDK, National Institutes of Health, USA
Short Talk: Heritable Activity: A Prion that Propagates by Covalent Auto-Activation

Friday, January 23 | 9:20AM - 9:40AM
Coffee Break
Room: Pre-Function


Friday, January 23 | 11:00AM - 1:00PM
Poster Setup
Room: Bay Room


Friday, January 23 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay Room


Friday, January 23 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Pre-Function


Friday, January 23 | 5:00PM - 7:15PM
DNA Methylation as Mediators
Room: Mountain/Lake Rooms

Speaker 1 of 5
* Timothy H. Bestor, Columbia University College of Physicians and Surgeons, USA
The Methylation Landscape of the Human Genome

Friday, January 23 | 5:00PM - 7:15PM
DNA Methylation as Mediators
Room: Mountain/Lake Rooms

Speaker 2 of 5
Rolf Ohlsson, Karolinska Institute, Sweden
The Mechanism of Genomic Imprinting: The CTCF/BORIS Connection

Friday, January 23 | 5:00PM - 7:15PM
DNA Methylation as Mediators
Room: Mountain/Lake Rooms

Speaker 3 of 5
Steven E. Jacobsen, University of California, Los Angeles, USA
Genetics of DNA Methylation in Arabidopsis

Friday, January 23 | 5:00PM - 7:15PM
DNA Methylation as Mediators
Room: Mountain/Lake Rooms

Speaker 4 of 5
Takashi Sado, National Institute of Genetics, Japan
Short Talk: De novo DNA Methylation is Dispensable for the Initiation and Propagation of X Chromosome Inactivation

Friday, January 23 | 5:00PM - 7:15PM
DNA Methylation as Mediators
Room: Mountain/Lake Rooms

Speaker 5 of 5
Isao Suetake, Institute for Protein Research, Japan
Short Talk: DNMT3L Stimulates DNA Methylation Activity of Dnmt3a and Dnmt3b in vitro

Friday, January 23 | 7:15PM - 8:15PM
Dinner
Room: Granhall


Friday, January 23 | 8:00PM - 10:30PM
Poster Session 2
Room: Bay Room


Friday, January 23 | 8:15PM - 9:15PM
Social Hour
Room: Bay Room


Saturday, January 24 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Saturday, January 24 | 8:00AM - 11:00AM
RNA Mediators
Room: Mountain/Lake Rooms

Speaker 1 of 6
Peter Fraser, Florida State University, USA
Intergenic Transcription-Dependent Chromatin Modification is Required for Long-Range Enhancer Interactions

Saturday, January 24 | 8:00AM - 11:00AM
RNA Mediators
Room: Mountain/Lake Rooms

Speaker 2 of 6
Jeannie T. Lee, Massachusetts General Hospital / Harvard Medical School, USA
Noncoding Transcribed Elements of the X-Inactivation Center

Saturday, January 24 | 8:00AM - 11:00AM
RNA Mediators
Room: Mountain/Lake Rooms

Speaker 3 of 6
* Marjori Ann Matzke, Institute of Plant and Microbial Biology, Academy Sinica, Taiwan
Genetic Analysis of RNA Directed DNA Methylation

Saturday, January 24 | 8:00AM - 11:00AM
RNA Mediators
Room: Mountain/Lake Rooms

Speaker 4 of 6
Judith Bender, Brown University, USA
RNA Signals for DNA Methylation of Endogenous Genes in Arabidopsis

Saturday, January 24 | 8:00AM - 11:00AM
RNA Mediators
Room: Mountain/Lake Rooms

Speaker 5 of 6
Hristo B. Houbaviy, Massachusetts Institute of Technology, USA
Short Talk: An Embryonic Stem Cell-Specific microRNA Cluster

Saturday, January 24 | 8:00AM - 11:00AM
RNA Mediators
Room: Mountain/Lake Rooms

Speaker 6 of 6
Susanna Mlynarczyk-Evans, University of California, San Francisco, USA
Short Talk: X Chromosome Non-Equivalence in ES Cells Predicts Active and Inactive X Chromosome Fates

Saturday, January 24 | 9:20AM - 9:40AM
Coffee Break
Room: Pre-Function


Saturday, January 24 | 11:00AM - 1:00PM
Poster Setup
Room: Bay Room


Saturday, January 24 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay Room


Saturday, January 24 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Pre-Function


Saturday, January 24 | 5:00PM - 7:15PM
Nuclear Compartments
Room: Mountain/Lake Rooms

Speaker 1 of 6
Gary Felsenfeld, NIDDK, National Institutes of Health, USA
Vertebrate Chromatin Insulators and Boundaries

Saturday, January 24 | 5:00PM - 7:15PM
Nuclear Compartments
Room: Mountain/Lake Rooms

Speaker 2 of 6
Nancy E. Cooke, University of Pennsylvania, USA
Short Talk: Roles of LCR Determinants in Long-Range Gene Activation

Saturday, January 24 | 5:00PM - 7:15PM
Nuclear Compartments
Room: Mountain/Lake Rooms

Speaker 3 of 6
Séverine Chambeyron, Institute of Human Genetics, France
Short Talk: Altered Nuclear Organization of the Hoxb Locus upon Induction of High Levels of Transcription is not a Simple Consequence of Histone Acetylation

Saturday, January 24 | 5:00PM - 7:15PM
Nuclear Compartments
Room: Mountain/Lake Rooms

Speaker 4 of 6
Abby F. Dernburg, University of California, Berkeley, USA
Short Talk: A Novel Regulator of Large-Scale Meiotic Chromosome Dynamics in C. elegans

Saturday, January 24 | 5:00PM - 7:15PM
Nuclear Compartments
Room: Mountain/Lake Rooms

Speaker 5 of 6
Dirk Schübeler, Friedrich Miescher Institute for Biomedical Research, Switzerland
The Interplay between Histone Modifications, Transcription and DNA Replication

Saturday, January 24 | 5:00PM - 7:15PM
Nuclear Compartments
Room: Mountain/Lake Rooms

Speaker 6 of 6
* Pamela K. Geyer, University of Iowa, USA
Genome Organization and Gene Regulation: The Role of Insulators in Defining Chromatin Domains

Saturday, January 24 | 7:15PM - 8:15PM
Dinner
Room: Granhall


Saturday, January 24 | 8:00PM - 10:30PM
Poster Session 3
Room: Bay Room


Saturday, January 24 | 8:15PM - 9:15PM
Social Hour
Room: Bay Room


Sunday, January 25 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Sunday, January 25 | 8:00AM - 11:00AM
Chromatin Modifiers
Room: Mountain/Lake Rooms

Speaker 1 of 6
* Robert E. Kingston, Massachusetts General Hospital, USA
Mechanisms to Target and Spread Repression by Polycomb-Group Complexes

Sunday, January 25 | 8:00AM - 11:00AM
Chromatin Modifiers
Room: Mountain/Lake Rooms

Speaker 2 of 6
Robert A. Martienssen, Cold Spring Harbor Laboratory, USA
Transposable Elements, RNA Interference and the Origin of Heterochromatin

Sunday, January 25 | 8:00AM - 11:00AM
Chromatin Modifiers
Room: Mountain/Lake Rooms

Speaker 3 of 6
Geneviève Almouzni, Centre National de la Recherche Scientifique, France
From Nucleosome to Heterochromatin: Their Formation and Maintenance

Sunday, January 25 | 8:00AM - 11:00AM
Chromatin Modifiers
Room: Mountain/Lake Rooms

Speaker 4 of 6
Steven Henikoff, Fred Hutchinson Cancer Research Center, USA
Nucleosome Assembly Pathways and the Maintenance of Chromatin States

Sunday, January 25 | 8:00AM - 11:00AM
Chromatin Modifiers
Room: Mountain/Lake Rooms

Speaker 5 of 6
Gary Karpen, University of California, Berkeley, USA
Short Talk: Epigenetic Properties of Centromeric Chromatin

Sunday, January 25 | 8:00AM - 11:00AM
Chromatin Modifiers
Room: Mountain/Lake Rooms

Speaker 6 of 6
Nicole M. Hagemann, University of Chicago, USA
Short Talk: Genetic Analysis of the Role of Chromatin Structure in the Expression of Genes Located within the Centromeres of Arabidopsis

Sunday, January 25 | 9:00AM - 12:00PM
Entertainment
Room: Mountain/Lake Rooms


Sunday, January 25 | 9:20AM - 9:40AM
Coffee Break
Room: Pre-Function


Sunday, January 25 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Pre-Function


Sunday, January 25 | 5:00PM - 7:15PM
Clinical and Agricultural Applications
Room: Mountain/Lake Rooms

Speaker 1 of 5
Carole Charlier, University of Liège, Belgium
Polar Overdominance at the Ovine Callipyge locus Supports Trans Interaction between the Products of Reciprocally Imprinted Genes

Sunday, January 25 | 5:00PM - 7:15PM
Clinical and Agricultural Applications
Room: Mountain/Lake Rooms

Speaker 2 of 5
Victor V. Lobanenkov, NIAID, National Institutes of Health, USA
CTCF and BORIS in Cancer (Epi)genetics

Sunday, January 25 | 5:00PM - 7:15PM
Clinical and Agricultural Applications
Room: Mountain/Lake Rooms

Speaker 3 of 5
Luca Comai, University of California, Davis Genome Center, USA
Ploidy Changes and Epigenetics in Arabidopsis

Sunday, January 25 | 5:00PM - 7:15PM
Clinical and Agricultural Applications
Room: Mountain/Lake Rooms

Speaker 4 of 5
Richard Amasino, University of Wisconsin, USA
Memories of Winter: Vernalization and the Competence to Flower

Sunday, January 25 | 5:00PM - 7:15PM
Clinical and Agricultural Applications
Room: Mountain/Lake Rooms

Speaker 5 of 5
Shuang Chang, Emory University, USA
Short Talk: Identification of DOST1, a Dominant Suppressor of Methylation-Induced Transgene Silencing in Arabidopsis

Sunday, January 25 | 7:15PM - 8:15PM
Social Hour
Room: Granhall


Sunday, January 25 | 8:15PM - 9:15PM
Dinner
Room: Mountain/Lake Rooms


Monday, January 26 | 10:26AM - 10:26AM
Departure


*Session Chair.