Web Desc
T Cell Development
Organizer(s): Frederick W. Alt, Harvey I. Cantor and James P. Allison
Date: February 10 - 15, 2004
Location: Fairmont Banff Springs, Banff, AB, Canada
Sponsored in part by the Director's Sponsor Fund
Summary of Meeting:
Upon completion of this conference, participants should: - Gain an updated on exciting research findings on T cell development including new advances in the elucidation of Transcription factors that regulate Th1/Th2 development; Development and selection of NK T cells; Transcriptional control of CD4/CD8 development; and factors that regulate VDJ recombination at the TCR locus - Gain insight into pivotal problems which include: the developmental relationship of suppression to effector CD4 cells and CD8 cells; Relationship of abnormalities in gene recombination to neoplasia; consensus view on development and TCR expression of CD4, CD8 and NK T cells. In the context of our objective, the goal of the meeting is to help generate new approaches to understanding transcriptional control of T cell development and also to help clarify and further develop our understanding of the relationship between dysregulated T cell development and disease mechanisms.
Discounted Abstract Deadline: October 9 2003
Discounted Registration Deadline: December 10 2003
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI058531-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, February 10 | 3:00PM - 7:00PM
Registration
Room: Van Horne Foyer


Tuesday, February 10 | 6:15PM - 7:15PM
Refreshments
Room: Van Horne Foyer


Tuesday, February 10 | 7:15PM - 7:30PM
Orientation
Room: Van Horne A


Tuesday, February 10 | 7:30PM - 8:30PM
Keynote Address
Room: Van Horne A

Speaker 1 of 1
Laurie H. Glimcher, Dana-Farber Cancer Institute, USA
Lineage Commitment in Lymphocytes


Wednesday, February 11 | 7:00AM - 8:00AM
Breakfast
Room: Alberta/New Brunswick


Wednesday, February 11 | 8:00AM - 11:15AM
Early Stem/Progenitor Development
Room: Van Horne A

Speaker 1 of 6
* Irving L. Weissman, Stanford University, USA
Normal and Leukemic Hemotopoiesis: Are Leukemias a Stem Cell Disorder or a Reacquisition of Stem Cell Characteristics

Wednesday, February 11 | 8:00AM - 11:15AM
Early Stem/Progenitor Development
Room: Van Horne A

Speaker 2 of 6
Katia Georgopoulos, Massachusetts General Hospital, USA
Transcription Factors and Early Commitment


Wednesday, February 11 | 8:00AM - 11:15AM
Early Stem/Progenitor Development
Room: Van Horne A

Speaker 3 of 6
Meinrad Busslinger, Research Institute of Molecular Pathology, Austria
Transcriptional Control of Lineage Commitment in Early Lymphophoiesis

Wednesday, February 11 | 8:00AM - 11:15AM
Early Stem/Progenitor Development
Room: Van Horne A

Speaker 4 of 6
Juan Carlos Zúñiga-Pflücker, Sunnybrook Research Institute, Canada
From Stem Cells to T Cells

Wednesday, February 11 | 8:00AM - 11:15AM
Early Stem/Progenitor Development
Room: Van Horne A

Speaker 5 of 6
Amy J. Wagers, Harvard University, USA
Short Talk: In vivo Dynamics of Hematopoietic Reconstitution following Transplant of Purified Stem and Progenitor Cells

Wednesday, February 11 | 8:00AM - 11:15AM
Early Stem/Progenitor Development
Room: Van Horne A

Speaker 6 of 6
Xiao-Hong Sun, Oklahoma Medical Research Foundation, USA
Short Talk: Notch-Induced E2A Degradation Contributes to the T versus B Lineage Decision

Wednesday, February 11 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Foyer


Wednesday, February 11 | 11:15AM - 1:00PM
Poster Setup
Room: Alberta/New Brunswick


Wednesday, February 11 | 1:00PM - 10:00PM
Poster Viewing
Room: Alberta/New Brunswick


Wednesday, February 11 | 2:00PM - 4:00PM
Workshop 1: Early Events in Commitment/Receptor Generation
Room: Van Horne A

Speaker 1 of 10
* Kristin A. Hogquist, University of Minnesota, USA

Wednesday, February 11 | 2:00PM - 4:00PM
Workshop 1: Early Events in Commitment/Receptor Generation
Room: Van Horne A

Speaker 2 of 10
* Pierre Ferrier, Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, France

Wednesday, February 11 | 2:00PM - 4:00PM
Workshop 1: Early Events in Commitment/Receptor Generation
Room: Van Horne A

Speaker 3 of 10
Cynthia J. Guidos, University of Toronto and Hospital for Sick Children, Canada
Functions of Lunatic Fringe and Notch Signaling in T Cell Commitment and Development

Wednesday, February 11 | 2:00PM - 4:00PM
Workshop 1: Early Events in Commitment/Receptor Generation
Room: Van Horne A

Speaker 4 of 10
Christine A. Goetz, University of North Carolina at Chapel Hill, USA
STAT5 Signals Regulate B versus T Cell Lineage Commitment

Wednesday, February 11 | 2:00PM - 4:00PM
Workshop 1: Early Events in Commitment/Receptor Generation
Room: Van Horne A

Speaker 5 of 10
Thomas Serwold, Joslin Diabetes Center, USA
The beta-Catenin Signaling Pathway is Maximally Active in the Earliest Thymocyte Progenitors and is Detectable in All Later T Cell Populations

Wednesday, February 11 | 2:00PM - 4:00PM
Workshop 1: Early Events in Commitment/Receptor Generation
Room: Van Horne A

Speaker 6 of 10
Adam G. W. Matthews, Massachusetts Institute of Technology, USA
Ordered DNA Release and Target Capture in RAG Transposition

Wednesday, February 11 | 2:00PM - 4:00PM
Workshop 1: Early Events in Commitment/Receptor Generation
Room: Van Horne A

Speaker 7 of 10
Megan M. Gleason, CBR Institute for Biomedical Research, USA
Dbeta/Jbeta Recombination Substrates can serve as Markers of Vbeta Accessibility and Vbeta to DJbeta Synapsis

Wednesday, February 11 | 2:00PM - 4:00PM
Workshop 1: Early Events in Commitment/Receptor Generation
Room: Van Horne A

Speaker 8 of 10
Brian B. Haines, Merck, USA
Deletion of a TCRbeta Variable Gene Promoter Results in Aberrant Vbeta Cleavage, Failure to Shut Down Vbeta Access, and Lymphomagenesis Under Conditions of Allelic Exclusion

Wednesday, February 11 | 2:00PM - 4:00PM
Workshop 1: Early Events in Commitment/Receptor Generation
Room: Van Horne A

Speaker 9 of 10
Timothy P. Bender, University of Virginia Health System, USA
Tissue Specific Inactivation Identifies Critical Roles for c-myb at Three Points during T Cell Development

Wednesday, February 11 | 2:00PM - 4:00PM
Workshop 1: Early Events in Commitment/Receptor Generation
Room: Van Horne A

Speaker 10 of 10
Verity Erin Mick, University of Minnesota, USA
Transforming Growth Factor beta Superfamily Signaling During T Lymphocyte Development

Wednesday, February 11 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Van Horne Foyer


Wednesday, February 11 | 5:00PM - 7:15PM
Normal and Abnormal TCR Rearrangement and Repertoire Develop
ment

Room: Van Horne A

Speaker 1 of 5
* Barry P. Sleckman, University of Alabama Birmingham School of Medicine, USA
Ordered Assembly of T Cell Receptor beta Chain Genes

Wednesday, February 11 | 5:00PM - 7:15PM
Normal and Abnormal TCR Rearrangement and Repertoire Develop
ment

Room: Van Horne A

Speaker 2 of 5
Craig H. Bassing, Children's Hospital of Philadelphia, USA
Short Talk: Regulated Assembly of T Cell Receptor Beta Variable Region Exons


Wednesday, February 11 | 5:00PM - 7:15PM
Normal and Abnormal TCR Rearrangement and Repertoire Develop
ment

Room: Van Horne A

Speaker 3 of 5
Jianzhu Chen, Massachusetts Institute of Technology, USA
Short Talk: The TCRbeta Variable Gene Promoter in Vbeta Recombination, Aberrant DNA Cleavages and Tumorigenesis

Wednesday, February 11 | 5:00PM - 7:15PM
Normal and Abnormal TCR Rearrangement and Repertoire Develop
ment

Room: Van Horne A

Speaker 4 of 5
Jean-Christophe Bories, Inserm, France
Short Talk: The Ets-1 Transcription Factor is Required for Pre-T Cell
Receptor Function and Allelic Exclusion at the TCR Beta Locus


Wednesday, February 11 | 5:00PM - 7:15PM
Normal and Abnormal TCR Rearrangement and Repertoire Develop
ment

Room: Van Horne A

Speaker 5 of 5
Michael S. Krangel, Duke University Medical Center, USA
Promoter-Directed Recombinase Targeting and the Dynamics of TCRalpha Rearrangement

Wednesday, February 11 | 7:15PM - 8:15PM
Social Hour
Room: Alberta/New Brunswick


Wednesday, February 11 | 7:30PM - 10:00PM
Poster Session 1: Early Development: Stem Cell to Thymocyte
Room: Alberta/New Brunswick


Thursday, February 12 | 7:00AM - 8:00AM
Breakfast
Room: Alberta/New Brunswick


Thursday, February 12 | 8:00AM - 11:00AM
Intrathymic T Cell Development
Room: Van Horne A

Speaker 1 of 5
* Harald von Boehmer, Harvard Medical School, USA
Surrogate TCRalpha Chain: Fact or Misconception?

Thursday, February 12 | 8:00AM - 11:00AM
Intrathymic T Cell Development
Room: Van Horne A

Speaker 2 of 5
Bernard Malissen, Centre d'Immunologie de Marseille-Luminy, France
Role of the LAT Adaptor in T Cell Development and Th1/Th2 Development

Thursday, February 12 | 8:00AM - 11:00AM
Intrathymic T Cell Development
Room: Van Horne A

Speaker 3 of 5
Gerald R. Crabtree, Stanford University, USA
Calcineurin/NFAT Signaling in Lymphocyte Development

Thursday, February 12 | 8:00AM - 11:00AM
Intrathymic T Cell Development
Room: Van Horne A

Speaker 4 of 5
Dan R. Littman, HHMI/New York University School of Medicine, USA
Role of Runx Transcription Factors in T Cell Development

Thursday, February 12 | 8:00AM - 11:00AM
Intrathymic T Cell Development
Room: Van Horne A

Speaker 5 of 5
Michel C. Nussenzweig, HHMI/Rockefeller University, USA
Short Talk: A cis Element in the Recombinase Activating Gene Locus Regulates Gene Expression by Counteracting a Distant Silencer

Thursday, February 12 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Foyer


Thursday, February 12 | 11:00AM - 1:00PM
Poster Setup
Room: Alberta/New Brunswick


Thursday, February 12 | 1:00PM - 10:00PM
Poster Viewing
Room: Alberta/New Brunswick


Thursday, February 12 | 2:00PM - 4:00PM
Workshop 2: Checkpoint in T Cell Maturation
Room: Van Horne A

Speaker 1 of 10
* B. J. Fowlkes, NIAID, National Institutes of Health, USA

Thursday, February 12 | 2:00PM - 4:00PM
Workshop 2: Checkpoint in T Cell Maturation
Room: Van Horne A

Speaker 2 of 10
* Craig H. Bassing, Children's Hospital of Philadelphia, USA

Thursday, February 12 | 2:00PM - 4:00PM
Workshop 2: Checkpoint in T Cell Maturation
Room: Van Horne A

Speaker 3 of 10
Vernon McNeil Coffield, University of North Carolina at Chapel Hill, USA
Inhibition of Galpha12/13 Signaling Blocks Thymopoiesis at the DN3 Stage of Development

Thursday, February 12 | 2:00PM - 4:00PM
Workshop 2: Checkpoint in T Cell Maturation
Room: Van Horne A

Speaker 4 of 10
Jennifer O. Manilay, University of California, Merced, USA
The Role of Kuzbanian in Notch Signaling and T Cell Development

Thursday, February 12 | 2:00PM - 4:00PM
Workshop 2: Checkpoint in T Cell Maturation
Room: Van Horne A

Speaker 5 of 10
Sung-Yun Pai, Dana Farber Cancer Institute, USA
GATA-3 has Multiple Roles in Thymocyte Development

Thursday, February 12 | 2:00PM - 4:00PM
Workshop 2: Checkpoint in T Cell Maturation
Room: Van Horne A

Speaker 6 of 10
Maria Ciofani, Skirball Institute of Biomolecular Medicine, USA
Requirement for Notch Signaling during TCR beta-Selection

Thursday, February 12 | 2:00PM - 4:00PM
Workshop 2: Checkpoint in T Cell Maturation
Room: Van Horne A

Speaker 7 of 10
Christine Borowski, Access Industries, USA
pTalpha and TCRalpha are not Functionally Interchangeable as Partners of TCRbeta during T Cell cevelopment

Thursday, February 12 | 2:00PM - 4:00PM
Workshop 2: Checkpoint in T Cell Maturation
Room: Van Horne A

Speaker 8 of 10
Ian M. Catlett, University of California, San Diego, USA
Suppressor of Cytokine Signaling 1 Positively Regulates T Cell Receptor Signaling

Thursday, February 12 | 2:00PM - 4:00PM
Workshop 2: Checkpoint in T Cell Maturation
Room: Van Horne A

Speaker 9 of 10
Tetsuya Yamagata, Tempero Pharmaceuticals, USA
Down-Regulation of the CD8beta Gene by “Self' Peptide is Coupled with the Acquisition of “Innate” Properties by Differentiating Thymocytes

Thursday, February 12 | 2:00PM - 4:00PM
Workshop 2: Checkpoint in T Cell Maturation
Room: Van Horne A

Speaker 10 of 10
Herbert Kasler, University of California, San Francisco, USA
Short Talk: HDAC7 Regulates Apoptosis in Developing Thymocytes

Thursday, February 12 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Van Horne Foyer


Thursday, February 12 | 5:00PM - 7:15PM
Clonal Expansion, Stimuli and Checkpoints
Room: Van Horne A

Speaker 1 of 4
* James P. Allison, University of Texas MD Anderson Cancer Center, USA
Negative Regulation of T Cell Expansion


Thursday, February 12 | 5:00PM - 7:15PM
Clonal Expansion, Stimuli and Checkpoints
Room: Van Horne A

Speaker 2 of 4
Arlene H. Sharpe, Harvard Medical School, USA
Molecular Interaction Underlying Co-Stimulation


Thursday, February 12 | 5:00PM - 7:15PM
Clonal Expansion, Stimuli and Checkpoints
Room: Van Horne A

Speaker 3 of 4
Leo Lefrançois, University of Connecticut Health Center, USA
Regulation of T Cell Development and Homeostasis by IL-15

Thursday, February 12 | 5:00PM - 7:15PM
Clonal Expansion, Stimuli and Checkpoints
Room: Van Horne A

Speaker 4 of 4
Richard A. Flavell, HHMI/Yale University School of Medicine, USA
Cytokine Dependent Regulation of T Cell Suppression


Thursday, February 12 | 7:15PM - 8:15PM
Social Hour
Room: Alberta/New Brunswick


Thursday, February 12 | 7:30PM - 10:00PM
Poster Session 2: T Cell Subset Development and Function 1
Room: Alberta/New Brunswick


Friday, February 13 | 7:00AM - 8:00AM
Breakfast
Room: Alberta/New Brunswick


Friday, February 13 | 8:00AM - 11:00AM
Thymic and Post-Thymic Differentiation of Effector and Memor
y T Cells

Room: Van Horne A

Speaker 1 of 5
* Mitchell Kronenberg, La Jolla Institute for Allergy and Immunology, USA
Development, Specificity and Function of NKT Cells

Friday, February 13 | 8:00AM - 11:00AM
Thymic and Post-Thymic Differentiation of Effector and Memor
y T Cells

Room: Van Horne A

Speaker 2 of 5
Pamela J. Fink, University of Washington, USA
Continued Maturation of Thymic Emigrants in the Lymphoid Periphery

Friday, February 13 | 8:00AM - 11:00AM
Thymic and Post-Thymic Differentiation of Effector and Memor
y T Cells

Room: Van Horne A

Speaker 3 of 5
Rose Zamoyska, University of Edinburgh, UK
Receptor Signals that Maintain Naïve and Memory Peripheral T Cells

Friday, February 13 | 8:00AM - 11:00AM
Thymic and Post-Thymic Differentiation of Effector and Memor
y T Cells

Room: Van Horne A

Speaker 4 of 5
Susan M. Kaech, The Salk Institute, USA
Short Talk: Selective Expression of IL-7 Receptor Identifies Effector CD8 T Cells that Give Rise to Long Lived Memory Cells

Friday, February 13 | 8:00AM - 11:00AM
Thymic and Post-Thymic Differentiation of Effector and Memor
y T Cells

Room: Van Horne A

Speaker 5 of 5
Hilde Cheroutre, La Jolla Institute for Allergy and Immunology, USA
CD8alphaalpha has an Unexpected Role in Natural and Aquired Memory of CD8 T Cells

Friday, February 13 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Foyer


Friday, February 13 | 11:00AM - 1:00PM
Poster Setup
Room: Alberta/New Brunswick


Friday, February 13 | 1:00PM - 10:00PM
Poster Viewing
Room: Alberta/New Brunswick


Friday, February 13 | 2:00PM - 4:00PM
Workshop 3: T Cell Lineage Commitment
Room: Van Horne A

Speaker 1 of 9
* Kim Bottomly, Yale University School of Medicine, USA

Friday, February 13 | 2:00PM - 4:00PM
Workshop 3: T Cell Lineage Commitment
Room: Van Horne A

Speaker 2 of 9
Jose Alberola-Ila, California Institute of Technology, USA
GATA-3 Expression is Controlled by TCR Signals and Regulates CD4/CD8 Differentiation

Friday, February 13 | 2:00PM - 4:00PM
Workshop 3: T Cell Lineage Commitment
Room: Van Horne A

Speaker 3 of 9
Rafal Pacholczyk, Georgia Regents University, USA
The Kinetics of TCR and MHC/Peptide Ligand Interaction is a Crucial Determinant of Thymocyte Lineage Commitment in Addition to the Specificity of the alphabeta TCR

Friday, February 13 | 2:00PM - 4:00PM
Workshop 3: T Cell Lineage Commitment
Room: Van Horne A

Speaker 4 of 9
Rémy Bosselut, National Cancer Institute, National Institutes of Health, USA
Analyzing CD4/CD8 Lineage Differentiation in vivo by Stage-Specific Disruption of Intrathymic TCR Signaling

Friday, February 13 | 2:00PM - 4:00PM
Workshop 3: T Cell Lineage Commitment
Room: Van Horne A

Speaker 5 of 9
Marc Ehlers, Rockefeller University, USA
Runx3/AML2 Regulates CD4 and Additional Gene Expression during CD4/CD8 Lineage Commitment

Friday, February 13 | 2:00PM - 4:00PM
Workshop 3: T Cell Lineage Commitment
Room: Van Horne A

Speaker 6 of 9
Batu Erman, National Institutes of Health, USA
The Cytoplasmic Tails of the CD4 and CD8 Co-Receptors Determine the CD4:CD8 Ratio

Friday, February 13 | 2:00PM - 4:00PM
Workshop 3: T Cell Lineage Commitment
Room: Van Horne A

Speaker 7 of 9
Takashi Usui, Kyoto University, Japan
GATA-3 Suppresses Th1 Development by Down-Regulation of Stat4, Not Through Effects on IL-12R Beta2 Chain or T-bet


Friday, February 13 | 2:00PM - 4:00PM
Workshop 3: T Cell Lineage Commitment
Room: Van Horne A

Speaker 8 of 9
Osamu Kaminuma, Tokyo Metropolitan Institute of Medical Science, Japan
GATA-3 Suppresses IFN-gamma Gene Transcription Independently of Binding to the cis-Regulatory Elements

Friday, February 13 | 2:00PM - 4:00PM
Workshop 3: T Cell Lineage Commitment
Room: Van Horne A

Speaker 9 of 9
Tatyana Chtanova, University of California, Berkeley, USA
T Follicular Helper Cells Distinguished from Th1 and Th2 Subsets by their Expression of Certain Cytokines, Cell Surface Molecules and the Transcription Factor BCL-6

Friday, February 13 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Van Horne Foyer


Friday, February 13 | 5:00PM - 7:15PM
Development of Th1/ Th2 Cells
Room: Van Horne A

Speaker 1 of 4
Anne O'Garra, Francis Crick Institute, UK
IL-10 and TH1/TH2 Development


Friday, February 13 | 5:00PM - 7:15PM
Development of Th1/ Th2 Cells
Room: Van Horne A

Speaker 2 of 4
Richard M. Locksley, HHMI/University of California, San Francisco, USA
Activation of Cytokine Expression in Naïve Helper T Cells

Friday, February 13 | 5:00PM - 7:15PM
Development of Th1/ Th2 Cells
Room: Van Horne A

Speaker 3 of 4
Steven L. Reiner, Columbia University, USA
Transcriptional Control of Effector T Cell Fate

Friday, February 13 | 5:00PM - 7:15PM
Development of Th1/ Th2 Cells
Room: Van Horne A

Speaker 4 of 4
* Kenneth M. Murphy, HHMI/Washington University School of Medicine, USA
BTLA, an Inhibitory Receptor in Lymphocytes with Similarities to CTLA-4 and PD-1

Friday, February 13 | 7:15PM - 8:15PM
Social Hour
Room: Alberta/New Brunswick


Friday, February 13 | 7:30PM - 10:00PM
Poster Session 3: T Cell Subset Development and Function 2
Room: Alberta/New Brunswick


Saturday, February 14 | 7:00AM - 8:00AM
Breakfast
Room: Alberta/New Brunswick


Saturday, February 14 | 8:00AM - 11:00AM
Regulatory T Cells: Development and Function
Room: Van Horne A

Speaker 1 of 4
* Harvey Cantor, Dana Farber Cancer Institute, USA
Deletional and Suppressive Mechanisms that Maintain Self-Tolerance


Saturday, February 14 | 8:00AM - 11:00AM
Regulatory T Cells: Development and Function
Room: Van Horne A

Speaker 2 of 4
Hong Jiang, Columbia University, USA
Short Talk: Regulatory CD8+ T Cells Function to Maintain Peripheral Self-Tolerance and Facilitate Affinity Maturation of T Cells to Foreign Antigens

Saturday, February 14 | 8:00AM - 11:00AM
Regulatory T Cells: Development and Function
Room: Van Horne A

Speaker 3 of 4
Alexander Y. Rudensky, HHMI/Memorial Sloan Kettering Cancer Center, USA
Mechanisms of Development and Function of Regulatory CD4 T Cells

Saturday, February 14 | 8:00AM - 11:00AM
Regulatory T Cells: Development and Function
Room: Van Horne A

Speaker 4 of 4
Juan J. Lafaille, New York University School of Medicine, USA
Regulatory T Cells in Autoimmunity and Allergy

Saturday, February 14 | 9:00AM - 12:00PM
Entertainment
Room: Cascade/Conservatory


Saturday, February 14 | 9:00AM - 12:00PM
Cash Bar
Room: Cascade/Conservatory


Saturday, February 14 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Foyer


Saturday, February 14 | 2:00PM - 4:00PM
Workshop 4: Regulatory Defects and Disease
Room: Van Horne A

Speaker 1 of 10
* Nora E. Sarvetnick, University of Nebraska Medical Center, USA

Saturday, February 14 | 2:00PM - 4:00PM
Workshop 4: Regulatory Defects and Disease
Room: Van Horne A

Speaker 2 of 10
* C. Garrison Fathman, Stanford University, USA

Saturday, February 14 | 2:00PM - 4:00PM
Workshop 4: Regulatory Defects and Disease
Room: Van Horne A

Speaker 3 of 10
Roland Grenningloh, Merck Serono, Germany
Ets-1: A Key Factor for the Development of Th1 Effector Functions

Saturday, February 14 | 2:00PM - 4:00PM
Workshop 4: Regulatory Defects and Disease
Room: Van Horne A

Speaker 4 of 10
Emily S. Venanzi, Joslin Diabetes Center, USA
Aire Influences Negative Selection and the Development of Autoimmunity

Saturday, February 14 | 2:00PM - 4:00PM
Workshop 4: Regulatory Defects and Disease
Room: Van Horne A

Speaker 5 of 10
Maureen McGargill, St Jude Children's Research Hospital, USA
Drak2, a Negative Regulator of Lymphocyte Signaling

Saturday, February 14 | 2:00PM - 4:00PM
Workshop 4: Regulatory Defects and Disease
Room: Van Horne A

Speaker 6 of 10
Noriyuki Kuroda, Institute for Enzyme Research, University of Tokushima, Japan
A Novel Enzymatic Function of AIRE

Saturday, February 14 | 2:00PM - 4:00PM
Workshop 4: Regulatory Defects and Disease
Room: Van Horne A

Speaker 7 of 10
Matthew A. Burchill, University of Minnesota, USA
STAT5 Activation Governs the IL-2-Dependant Development of CD4+CD25+ regulatory T cells

Saturday, February 14 | 2:00PM - 4:00PM
Workshop 4: Regulatory Defects and Disease
Room: Van Horne A

Speaker 8 of 10
Jianwei Li, Memorial Sloan-Kettering Cancer Center, USA
The Analysis of Low-Affinity T Cells Specific for MBP Peptide in the Development of EAE

Saturday, February 14 | 2:00PM - 4:00PM
Workshop 4: Regulatory Defects and Disease
Room: Van Horne A

Speaker 9 of 10
Emma E. Hamilton-Williams, University of Queensland, Australia
Toll-Like Receptor Ligands Lower the Precursor Frequency of Autoreactive CD8 T Cells Required for Autoimmunity, but do Not Break Cross-Tolerance

Saturday, February 14 | 2:00PM - 4:00PM
Workshop 4: Regulatory Defects and Disease
Room: Van Horne A

Speaker 10 of 10
Renu G. Jain, Grifols S.A., USA
IL-10 Nullifies CTLA-4 Inhibitory Function to Sustain Activation of Islet-Resident Diabetogenic CD4 T Cells and Development of Diabetes

Saturday, February 14 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Van Horne Foyer


Saturday, February 14 | 5:00PM - 7:15PM
Dysregulated T Cell Development: Autoimmunity and Cancer
Room: Van Horne A

Speaker 1 of 5
* Diane Mathis, Harvard Medical School, USA
Aire

Saturday, February 14 | 5:00PM - 7:15PM
Dysregulated T Cell Development: Autoimmunity and Cancer
Room: Van Horne A

Speaker 2 of 5
C. Garrison Fathman, Stanford University, USA
Short Talk: GRAIL, an E3 Ubiquitin Ligase, is Necessary for Anergy Induction in CD4+ T Cells

Saturday, February 14 | 5:00PM - 7:15PM
Dysregulated T Cell Development: Autoimmunity and Cancer
Room: Van Horne A

Speaker 3 of 5
Thomas Thomas Look, Dana-Farber Cancer Institute, USA
The Emerging Genetics of T-Cell Acute Lymphoblastic Leukemia: A Fish Tale

Saturday, February 14 | 5:00PM - 7:15PM
Dysregulated T Cell Development: Autoimmunity and Cancer
Room: Van Horne A

Speaker 4 of 5
André Nussenzweig, NCI, National Institutes of Health, USA
Checkpoint and Repair Pathways Monitoring Normal and Abnormal TCR Rearrangements

Saturday, February 14 | 5:00PM - 7:15PM
Dysregulated T Cell Development: Autoimmunity and Cancer
Room: Van Horne A

Speaker 5 of 5
Frederick W. Alt, Boston Children's Hospital, USA
Linking Histones to Cancer

Saturday, February 14 | 8:00PM - 9:00PM
Social Hour
Room: Cascade/Conservatory


Sunday, February 15 | 10:26AM - 10:26AM
Departure


*Session Chair.