Web Desc
Mouse Models of Human Cancer
Organizer(s): Allan Balmain and Tyler Jacks
Date: February 17 - 22, 2004
Location: Keystone Resort, Keystone, CO, USA
Sponsored by Novartis Pharmaceuticals Corporation
Summary of Meeting:
The main theme of the meeting will be the exploration, using the best mouse models of the major human cancers, of questions related to the target cells for tumor development, the genetic basis to tumor susceptibility, sequential somatic genetic changes during tumor initiation promotion and progression, comparative mouse-human cancer genetics, the role of stromal/accessory cells, the immune response and cancer, and approaches to early detection using imaging or surrogate markers. A major objective will be to emphasize the parallels between mouse models and human cancers, and the advantages of these models to address questions related not only to the basic biology, but also to more practical aspects of gene discovery and therapy. Two of the sessions will be on the functions of stromal/endothelial/immune cells in cancer development to explore non-cell autonomous effects in tumor growth.
Discounted Abstract Deadline: October 16 2003
Discounted Registration Deadline: December 24 2003
We gratefully acknowledge additional support for this conference from:
AVEO Pharmaceuticals, Inc.
Cell Signaling Technology, Inc.

Novartis Pharmaceuticals Corporation
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, February 17 | 3:00PM - 7:00PM
Registration
Room: Shavano Peak Foyer


Tuesday, February 17 | 6:15PM - 7:15PM
Refreshments
Room: Shavano Peak Foyer


Tuesday, February 17 | 7:15PM - 7:30PM
Orientation
Room: Red Cloud


Tuesday, February 17 | 7:30PM - 9:30PM
Keynote Session
Room: Red Cloud

Speaker 1 of 3
* Tyler Jacks, Massachusetts Institute of Technology, USA

Tuesday, February 17 | 7:30PM - 9:30PM
Keynote Session
Room: Red Cloud

Speaker 2 of 3
J. Michael Bishop, University of California, San Francisco, USA
Mouse Models Rule

Tuesday, February 17 | 7:30PM - 9:30PM
Keynote Session
Room: Red Cloud

Speaker 3 of 3
Harold E. Varmus, Weill Cornell Medical College, USA
Making Mouse Models is Not the Same as Using Them: What We Should be Learning

Wednesday, February 18 | 7:00AM - 8:00AM
Breakfast
Room: Shavano/Torreys


Wednesday, February 18 | 8:00AM - 11:15AM
Comparative Mouse-Human Cancer Genetics
Room: Red Cloud

Speaker 1 of 7
Jeffrey E. Green, National Cancer Institute, National Institutes of Health, USA
Genomic Approaches to Define the Molecular Anatomy of Mouse Mammary Cancer Models and Their Relationship to Human Breast Cancer

Wednesday, February 18 | 8:00AM - 11:15AM
Comparative Mouse-Human Cancer Genetics
Room: Red Cloud

Speaker 2 of 7
Donna G. Albertson, University of California, San Francisco, USA
Genomic Alterations in Mouse and Human Cancers

Wednesday, February 18 | 8:00AM - 11:15AM
Comparative Mouse-Human Cancer Genetics
Room: Red Cloud

Speaker 3 of 7
* Ronald A. DePinho, University of Texas MD Anderson Cancer Center, USA
Modeling Cancer and Cancer Genomes in the Mouse

Wednesday, February 18 | 8:00AM - 11:15AM
Comparative Mouse-Human Cancer Genetics
Room: Red Cloud

Speaker 4 of 7
Tyler Jacks, Massachusetts Institute of Technology, USA
Modeling Lung Cancer in the Mouse

Wednesday, February 18 | 8:00AM - 11:15AM
Comparative Mouse-Human Cancer Genetics
Room: Red Cloud

Speaker 5 of 7
E. Alejandro Sweet-Cordero, Stanford University, USA
Short Talk

Wednesday, February 18 | 8:00AM - 11:15AM
Comparative Mouse-Human Cancer Genetics
Room: Red Cloud

Speaker 6 of 7
Alan R. Clarke, Cardiff University, UK
Short Talk: Investigating the Functional Requirement for Apc through Conditional Deletion in the Mouse

Wednesday, February 18 | 8:00AM - 11:15AM
Comparative Mouse-Human Cancer Genetics
Room: Red Cloud

Speaker 7 of 7
Matthias Hebrok, University of California, San Francisco, USA
Short Talk: Embryonic Signaling Pathways in Pancreatic Cancer

Wednesday, February 18 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Wednesday, February 18 | 11:15AM - 1:00PM
Poster Setup
Room: Shavano/Torreys


Wednesday, February 18 | 1:00PM - 10:00PM
Poster Viewing
Room: Shavano/Torreys


Wednesday, February 18 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Shavano Peak Foyer


Wednesday, February 18 | 5:00PM - 7:00PM
Stem Cells and Cancer
Room: Red Cloud

Speaker 1 of 4
* Elaine V. Fuchs, Rockefeller University, USA
Stem Cell Lineages of the Skin

Wednesday, February 18 | 5:00PM - 7:00PM
Stem Cells and Cancer
Room: Red Cloud

Speaker 2 of 4
Fiona M. Watt, King's College London School of Medicine, UK
Contribution of Stem Cells and Differentiated Cells to Tumors of the Epidermis

Wednesday, February 18 | 5:00PM - 7:00PM
Stem Cells and Cancer
Room: Red Cloud

Speaker 3 of 4
Robert J. Coffey, Jr., Vanderbilt University Medical Center, USA
New Insights into Progenitor Cells of the GI Tract: Less Clandestine in the Intestine

Wednesday, February 18 | 5:00PM - 7:00PM
Stem Cells and Cancer
Room: Red Cloud

Speaker 4 of 4
William M. Keyes, Cold Spring Harbor Laboratory, USA
Short Talk: P63 Ablation Activates Key Cellular Processes during Epidermal Morphogenesis

Wednesday, February 18 | 7:00PM - 8:00PM
Social Hour
Room: Shavano/Torreys


Wednesday, February 18 | 7:30PM - 10:00PM
Poster Session 1
Room: Shavano/Torreys


Thursday, February 19 | 7:00AM - 8:00AM
Breakfast
Room: Shavano/Torreys


Thursday, February 19 | 8:00AM - 11:30AM
Genetic Basis of Cancer Susceptibility
Room: Red Cloud

Speaker 1 of 6
Beverly A. Mock, NCI, National Institutes of Health, USA
Compound Defects in Cancer Susceptibility Genes Contribute to Plasmacytomagenesis

Thursday, February 19 | 8:00AM - 11:30AM
Genetic Basis of Cancer Susceptibility
Room: Red Cloud

Speaker 2 of 6
Allan Balmain, University of California, San Francisco, USA
Germline and Somatic Mutations in Mouse Models of Human Cancer

Thursday, February 19 | 8:00AM - 11:30AM
Genetic Basis of Cancer Susceptibility
Room: Red Cloud

Speaker 3 of 6
* William F. Dove, University of Wisconsin-Madison, USA
From the Apc-Min Mouse Model to Genes and Molecules Involved in Human Colon Cancer

Thursday, February 19 | 8:00AM - 11:30AM
Genetic Basis of Cancer Susceptibility
Room: Red Cloud

Speaker 4 of 6
David W. Threadgill, University of North Carolina at Chapel Hill, USA
Mouse Strain-Dependent Susceptibility to Colorectal Cancer and Colonization by the Gastrointestinal Flora

Thursday, February 19 | 8:00AM - 11:30AM
Genetic Basis of Cancer Susceptibility
Room: Red Cloud

Speaker 5 of 6
Lynn M. Matrisian, Vanderbilt University School of Medicine, USA
Mouse Models in Translational Research

Thursday, February 19 | 8:00AM - 11:30AM
Genetic Basis of Cancer Susceptibility
Room: Red Cloud

Speaker 6 of 6
Andrea I. McClatchey, Massachusetts General Hospital, USA
Short Talk: A Mouse Model of Stem Cell Derived Liver Cancer

Thursday, February 19 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Thursday, February 19 | 11:30AM - 1:00PM
Poster Setup
Room: Shavano/Torreys


Thursday, February 19 | 1:00PM - 10:00PM
Poster Viewing
Room: Shavano/Torreys


Thursday, February 19 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Shavano Peak Foyer


Thursday, February 19 | 5:00PM - 7:00PM
Tumor Imaging and Early Detection
Room: Red Cloud

Speaker 1 of 6
* Terry A. Van Dyke, National Cancer Institute, National Institutes of Health, USA

Thursday, February 19 | 5:00PM - 7:00PM
Tumor Imaging and Early Detection
Room: Red Cloud

Speaker 2 of 6
Christopher H. Contag, Institute for Quantitative Health Sciences and Engineering, USA
Advancing Mouse Models in-vivo Dynamic Imaging Systems

Thursday, February 19 | 5:00PM - 7:00PM
Tumor Imaging and Early Detection
Room: Red Cloud

Speaker 3 of 6
Natasha Grant Deane, Vanderbilt University Medical Center, USA
Short Talk: The Use of High Field MRI to Detect and Characterize Cancer Progression in Experimental Mouse Livers

Thursday, February 19 | 5:00PM - 7:00PM
Tumor Imaging and Early Detection
Room: Red Cloud

Speaker 4 of 6
Leonard Hofstra, Maastricht University Hospital, Netherlands
Short Talk: Molecular Imaging of Apoptosis

Thursday, February 19 | 5:00PM - 7:00PM
Tumor Imaging and Early Detection
Room: Red Cloud

Speaker 5 of 6
Byron C. Hann, University of California, San Francisco, USA
Short Talk: A Murine Model for Rapid and Sensitive in vivo Tumor Detection

Thursday, February 19 | 5:00PM - 7:00PM
Tumor Imaging and Early Detection
Room: Red Cloud

Speaker 6 of 6
William G. Kaelin, Jr., Dana-Farber Cancer Institute, USA
Bioluminescent Imaging of Molecular Pathways Relevant to Cancer

Thursday, February 19 | 7:00PM - 8:00PM
Social Hour
Room: Shavano/Torreys


Thursday, February 19 | 7:30PM - 10:00PM
Poster Session 2
Room: Shavano/Torreys


Friday, February 20 | 7:00AM - 8:00AM
Breakfast
Room: Shavano/Torreys


Friday, February 20 | 8:00AM - 11:30AM
Genetically Engineered Models of Human Cancer. Session Spon
sored in part by GenPath Pharmaceuticals, Inc.

Room: Red Cloud

Speaker 1 of 5
Anton J. M. Berns, Netherlands Cancer Institute, Netherlands
Utility of Mouse Models for Human Cancer

Friday, February 20 | 8:00AM - 11:30AM
Genetically Engineered Models of Human Cancer. Session Spon
sored in part by GenPath Pharmaceuticals, Inc.

Room: Red Cloud

Speaker 2 of 5
Mariano Barbacid, Centro Nacional de Investigaciones Oncológicas, Spain
Engineering Mouse Models for Target Validation in Cancer: Cyclin-Dependent Kinases and their Inhibitors

Friday, February 20 | 8:00AM - 11:30AM
Genetically Engineered Models of Human Cancer. Session Spon
sored in part by GenPath Pharmaceuticals, Inc.

Room: Red Cloud

Speaker 3 of 5
Terry A. Van Dyke, National Cancer Institute, National Institutes of Health, USA
Modeling Cancer Mechanisms in the Mouse

Friday, February 20 | 8:00AM - 11:30AM
Genetically Engineered Models of Human Cancer. Session Spon
sored in part by GenPath Pharmaceuticals, Inc.

Room: Red Cloud

Speaker 4 of 5
* Guillermina Lozano, University of Texas MD Anderson Cancer Center, USA
Germline Mutations in the p53/Mdm2 Pathway and Cancer Development

Friday, February 20 | 8:00AM - 11:30AM
Genetically Engineered Models of Human Cancer. Session Spon
sored in part by GenPath Pharmaceuticals, Inc.

Room: Red Cloud

Speaker 5 of 5
Christopher J. Kemp, Fred Hutchinson Cancer Research Center, USA
The Genetics and Biology of Tumor Suppression by p27/Kip1

Friday, February 20 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Friday, February 20 | 11:30AM - 1:00PM
Poster Setup
Room: Shavano/Torreys


Friday, February 20 | 1:00PM - 10:00PM
Poster Viewing
Room: Shavano/Torreys


Friday, February 20 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Shavano Peak Foyer


Friday, February 20 | 5:00PM - 7:00PM
Stromal Cells and Tumor Development
Room: Red Cloud

Speaker 1 of 4
* Mary Helen Barcellos-Hoff, New York School of Medicine, USA
Non-Mutagenic Actions of Radiation Carcinogenesis in Mouse and Human Mammary Models

Friday, February 20 | 5:00PM - 7:00PM
Stromal Cells and Tumor Development
Room: Red Cloud

Speaker 2 of 4
Gerald R. Cunha, University of California, San Francisco, USA
Stromal Cell Control of Prostate Cancer Progression

Friday, February 20 | 5:00PM - 7:00PM
Stromal Cells and Tumor Development
Room: Red Cloud

Speaker 3 of 4
Erwin F. Wagner, Spanish National Cancer Research Centre, Spain
The Dual Functions of AP-1 (Fos/Jun) in Cancer Development

Friday, February 20 | 5:00PM - 7:00PM
Stromal Cells and Tumor Development
Room: Red Cloud

Speaker 4 of 4
Mikala Egeblad, Cold Spring Harbor Laboratory, USA
Short Talk: Real-Time Imaging of Mammary Carcinoma Progression

Friday, February 20 | 7:00PM - 8:00PM
Social Hour
Room: Shavano/Torreys


Friday, February 20 | 7:30PM - 10:00PM
Poster Session 3
Room: Shavano/Torreys


Saturday, February 21 | 7:00AM - 8:00AM
Breakfast
Room: Shavano/Torreys


Saturday, February 21 | 8:00AM - 11:00AM
Experimental Therapeutics Using Engineered Mouse Models
Room: Red Cloud

Speaker 1 of 7
* Douglas Hanahan, ISREC, Switzerland
Angiogenesis Inhibitors in Cancer Therapy

Saturday, February 21 | 8:00AM - 11:00AM
Experimental Therapeutics Using Engineered Mouse Models
Room: Red Cloud

Speaker 2 of 7
Johanna A. Joyce, University of Lausanne, Switzerland
Short Talk

Saturday, February 21 | 8:00AM - 11:00AM
Experimental Therapeutics Using Engineered Mouse Models
Room: Red Cloud

Speaker 3 of 7
Eric Holland, Memorial Sloan-Kettering Cancer Center, USA
Mouse Models of Glioma Formation and Maintenance

Saturday, February 21 | 8:00AM - 11:00AM
Experimental Therapeutics Using Engineered Mouse Models
Room: Red Cloud

Speaker 4 of 7
Scott W. Lowe, Memorial Sloan Kettering Cancer Center, USA
Linking Cancer Genetics to Cancer Therapy in Mouse Models

Saturday, February 21 | 8:00AM - 11:00AM
Experimental Therapeutics Using Engineered Mouse Models
Room: Red Cloud

Speaker 5 of 7
Pier Paolo Pandolfi, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Pokemon: The Birth and Raise of a Cancer Gene

Saturday, February 21 | 8:00AM - 11:00AM
Experimental Therapeutics Using Engineered Mouse Models
Room: Red Cloud

Speaker 6 of 7
Pernilla Roswall, Uppsala University, Sweden
Short Talk: Tumor Stroma as a Target for Therapy: Effects of TGF-beta Inhibition in Experimental Thyroid Carcinoma

Saturday, February 21 | 8:00AM - 11:00AM
Experimental Therapeutics Using Engineered Mouse Models
Room: Red Cloud

Speaker 7 of 7
Stephen N. Jones, University of Massachusetts Medical School, USA
Short Talk: Wnt5a Inhibits B Cell Proliferation and Functions as a Tumor Suppressor in Hematopoietic Tissue

Saturday, February 21 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Saturday, February 21 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Shavano Peak Foyer


Saturday, February 21 | 5:00PM - 7:00PM
Analysis of Regulatory Networks in Cancer Biology
Room: Red Cloud

Speaker 1 of 4
* Allan Balmain, University of California, San Francisco, USA

Saturday, February 21 | 5:00PM - 7:00PM
Analysis of Regulatory Networks in Cancer Biology
Room: Red Cloud

Speaker 2 of 4
Zoltan N. Oltvai, University of Pittsburgh Medical School, USA
Organization of Cellular Networks

Saturday, February 21 | 5:00PM - 7:00PM
Analysis of Regulatory Networks in Cancer Biology
Room: Red Cloud

Speaker 3 of 4
Luk Van Parijs, Massachusetts Institute of Technology, USA
Novel Tumor Suppressor Genes Revealed by a Mammalian RNA Interference Screen

Saturday, February 21 | 5:00PM - 7:00PM
Analysis of Regulatory Networks in Cancer Biology
Room: Red Cloud

Speaker 4 of 4
Kent W. Hunter, NCI, National Institutes of Health, USA
Integrating 'omic' Technologies to Interrogate the Molecular Basis of Mammary Tumor Metastasis

Saturday, February 21 | 7:00PM - 8:00PM
Social Hour
Room: Shavano/Torreys


Saturday, February 21 | 8:00PM - 11:00PM
Entertainment
Room: Shavano/Torreys


Saturday, February 21 | 8:00PM - 11:00PM
Cash Bar
Room: Shavano/Torreys


Sunday, February 22 | 10:26AM - 10:26AM
Departure


*Session Chair.