Web Desc
G-Protein-Coupled Receptors: Evolving Concepts and Drug Discovery
Organizer(s): Paul A. Insel and Graeme Milligan
Date: February 17 - 22, 2004
Location: Taos Convention Center (meeting only), Taos, NM, USA
Sponsored by Aventis Pharmaceuticals, Inc.
Summary of Meeting:
G-protein-coupled receptors (GPCRs), which comprise one of the largest gene families identified in the human genome, also represent the largest number of currently used targets of therapeutic drugs. Recent work has indicated a number of intriguing observations in terms of GPCR structure, function and regulation, including existence of receptor homodimers and heterodimers, genetic identification of orphan GPCRs, novel receptor interacting proteins, clinically important polymorphisms and receptor mutations, mechanisms involved in receptor deactivation/desensitization, and receptor targeting/action in signaling microdomains. Definitive information about each of these topics is still being developed. This symposium will focus on these and related topics with an emphasis on use of new tools, e.g., bioinformatic approaches to evaluate GPCR family members, novel strategies to identify ligands active at GPCRs, and insights from non-mammalian/lower eukaryotic systems. Attendees will thus have the chance to learn and discuss new cutting-edge topics regarding GPCRs.
Discounted Abstract Deadline: October 16 2003
Discounted Registration Deadline: December 17 2003
We gratefully acknowledge additional support for this conference from:
Sanofi US
Synaptic Pharmaceutical Corp.
We gratefully acknowledge the generous grant for this conference provided by:

National Institute on Drug Abuse (NIDA)
Grant No. 1R13DA017912-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, February 17 | 3:00PM - 7:00PM
Registration
Room: Rio Grande Hall D


Tuesday, February 17 | 6:15PM - 7:15PM
Refreshments
Room: Rio Grande A/B/C


Tuesday, February 17 | 7:15PM - 7:30PM
Orientation
Room: Bataan


Tuesday, February 17 | 7:30PM - 8:30PM
Keynote Address
Room: Bataan

Speaker 1 of 1
Robert J. Lefkowitz, HHMI/Duke University Medical Center, USA
A Brief History of Seven Membrane Spanning Receptors

Wednesday, February 18 | 7:00AM - 8:00AM
Breakfast
Room: Rio Grande A/B/C


Wednesday, February 18 | 8:00AM - 11:15AM
GPCR Structure and Oligomerization
Room: Bataan

Speaker 7 of 7
Nagarajan Vaidehi, City of Hope National Medical Center, USA
Short Talk: First Principles Structure and Function Prediction for G Protein-Coupled Receptors

Wednesday, February 18 | 8:00AM - 11:15AM
GPCR Structure and Oligomerization
Room: Bataan

Speaker 6 of 7
Jakob S. Hansen, Novo Nordisk A/S, Denmark
Short Talk: Oligomerization of Wild Type and Non-Functional Mutant Angiotensin II Type I (AT1) Receptors Inhibits Galphaq Signaling but Not ERK Activation

Wednesday, February 18 | 8:00AM - 11:15AM
GPCR Structure and Oligomerization
Room: Bataan

Speaker 5 of 7
Graeme Milligan, University of Glasgow, UK
Receptor Dimerization

Wednesday, February 18 | 8:00AM - 11:15AM
GPCR Structure and Oligomerization
Room: Bataan

Speaker 4 of 7
Kendall J. Blumer, Washington University School of Medicine, USA
Yeast GPCR Oligomerization

Wednesday, February 18 | 8:00AM - 11:15AM
GPCR Structure and Oligomerization
Room: Bataan

Speaker 3 of 7
Michel Bouvier, University of Montreal, Canada
Functional Role of 7TM Receptor Dimerization in Transport

Wednesday, February 18 | 8:00AM - 11:15AM
GPCR Structure and Oligomerization
Room: Bataan

Speaker 2 of 7
Krzysztof Palczewski, Case Western Reserve University, USA
Rhodopsin Structure and Activation

Wednesday, February 18 | 8:00AM - 11:15AM
GPCR Structure and Oligomerization
Room: Bataan

Speaker 1 of 7
* Dianne M. Perez, Cleveland Clinic Foundation, USA

Wednesday, February 18 | 9:20AM - 9:40AM
Coffee Break
Room: Rio Grande C/D


Wednesday, February 18 | 11:15AM - 1:00PM
Poster Setup
Room: Rio Grande


Wednesday, February 18 | 1:00PM - 10:00PM
Poster Viewing
Room: Rio Grande


Wednesday, February 18 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Foyer


Wednesday, February 18 | 5:00PM - 7:00PM
GPCR Interacting Proteins
Room: Bataan

Speaker 5 of 5
Thue W. Schwartz, University of Copenhagen, Denmark
Molecular Mechanisms of Activation of 7TM Receptors

Wednesday, February 18 | 5:00PM - 7:00PM
GPCR Interacting Proteins
Room: Bataan

Speaker 4 of 5
Hyeseon Cho, National Institutes of Health, USA
Short Talk: RGS14, A Centrosomal and Nuclear-Cytoplasmic Shuttling Protein Regulates Cell Cycle Progression

Wednesday, February 18 | 5:00PM - 7:00PM
GPCR Interacting Proteins
Room: Bataan

Speaker 3 of 5
Marilyn Gist Farquhar, University of California, San Diego, USA
RGS-PX1 Connects Gs to EGF Receptor Trafficking and Down-Regulation: From Cell Biology to Mouse Genetics

Wednesday, February 18 | 5:00PM - 7:00PM
GPCR Interacting Proteins
Room: Bataan

Speaker 2 of 5
Stephen M. Lanier, Louisiana State University Health Science Center, USA
AGS Proteins, GPR Motifs and the Signals Processed by Heterotrimeric G Proteins

Wednesday, February 18 | 5:00PM - 7:00PM
GPCR Interacting Proteins
Room: Bataan

Speaker 1 of 5
* Michael P. Lisanti, University of Manchester, UK

Wednesday, February 18 | 7:00PM - 8:00PM
Social Hour
Room: Rio Grande


Wednesday, February 18 | 7:30PM - 10:00PM
Poster Session 1
Room: Rio Grande


Wednesday, February 18 | 8:00PM - 9:00PM
Cash Bar
Room: Rio Grande


Thursday, February 19 | 7:00AM - 8:00AM
Breakfast
Room: Rio Grande A/B/C


Thursday, February 19 | 8:00AM - 11:00AM
GPCR Trafficking and Regulation
Room: Bataan

Speaker 1 of 6
* Robert J. Lefkowitz, HHMI/Duke University Medical Center, USA
Regulation of Seven Membrane Spanning Receptor Trafficking by Ubiquitination

Thursday, February 19 | 8:00AM - 11:00AM
GPCR Trafficking and Regulation
Room: Bataan

Speaker 2 of 6
Mark von Zastrow, University of California, San Francisco, USA
Regulation of G Protein-Coupled Receptors by Membrane Trafficking in the Endocytic Pathway

Thursday, February 19 | 8:00AM - 11:00AM
GPCR Trafficking and Regulation
Room: Bataan

Speaker 3 of 6
Andrew B. Tobin, University of Glasgow, UK
GPCR Phosphorylation Offers a 'Flexible' Adaptive Mechanism of Regulation

Thursday, February 19 | 8:00AM - 11:00AM
GPCR Trafficking and Regulation
Room: Bataan

Speaker 4 of 6
JoAnn Trejo, University of California, San Diego, USA
Regulation of Protease-Activated Receptor-1 Signaling and Trafficking

Thursday, February 19 | 8:00AM - 11:00AM
GPCR Trafficking and Regulation
Room: Bataan

Speaker 5 of 6
Patrick M. Sexton, Monash University, Australia
Short Talk: Molecular Characterization of Receptor Activity Modifying Proteins (RAMPs)

Thursday, February 19 | 8:00AM - 11:00AM
GPCR Trafficking and Regulation
Room: Bataan

Speaker 6 of 6
Sarah H. Cant, University College London, UK
Short Talk: Ezrin Represents a Novel Substrate of GRK2 with a Potential Role in Regulating GPCR Internalization and Cytoskeletal Reorganization

Thursday, February 19 | 9:20AM - 9:40AM
Coffee Break
Room: Rio Grande C/D


Thursday, February 19 | 11:00AM - 1:00PM
Poster Setup
Room: Rio Grande


Thursday, February 19 | 1:00PM - 10:00PM
Poster Viewing
Room: Rio Grande


Thursday, February 19 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Foyer


Thursday, February 19 | 5:00PM - 7:00PM
GPCR Signaling Microdomains
Room: Bataan

Speaker 1 of 5
* Marilyn Gist Farquhar, University of California, San Diego, USA

Thursday, February 19 | 5:00PM - 7:00PM
GPCR Signaling Microdomains
Room: Bataan

Speaker 2 of 5
Michael P. Lisanti, University of Manchester, UK
Role of Caveolin-1 in the Modulation of Lipolysis and Lipid Droplet Formation

Thursday, February 19 | 5:00PM - 7:00PM
GPCR Signaling Microdomains
Room: Bataan

Speaker 3 of 5
Jan E. Schnitzer, Proteogenomics Research Institute for Systems Medicine (PRISM), USA
Differential Integration of Signaling and Trafficking in Caveolae and Lipid Rafts by G Proteins and GPCRs

Thursday, February 19 | 5:00PM - 7:00PM
GPCR Signaling Microdomains
Room: Bataan

Speaker 4 of 5
Susan F. Steinberg, Columbia University, USA
Beta-Adrenergic Signaling in Cardiac Membrane Microdomains

Thursday, February 19 | 5:00PM - 7:00PM
GPCR Signaling Microdomains
Room: Bataan

Speaker 5 of 5
Yann Percherancier, Université de Montréal, Canada
Short Talk: Cholesterol Modulation of beta2-Adrenergic Receptor Characteristics by Sequestration of the Adenylyl-Cyclase V/VI in Raft Membranes

Thursday, February 19 | 7:00PM - 8:00PM
Social Hour
Room: Rio Grande


Thursday, February 19 | 7:30PM - 10:00PM
Poster Session 2
Room: Rio Grande


Thursday, February 19 | 8:00PM - 9:00PM
Cash Bar
Room: Rio Grande


Friday, February 20 | 7:00AM - 8:00AM
Breakfast
Room: Rio Grande A/B/C


Friday, February 20 | 8:00AM - 11:15AM
GPCRs in Olfaction, Infection and Immunity
Room: Bataan

Speaker 1 of 7
* Thue W. Schwartz, University of Copenhagen, Denmark

Friday, February 20 | 8:00AM - 11:15AM
GPCRs in Olfaction, Infection and Immunity
Room: Bataan

Speaker 2 of 7
Linda B. Buck, Fred Hutchinson Cancer Research Center, USA
Odor Coding in Mammals

Friday, February 20 | 8:00AM - 11:15AM
GPCRs in Olfaction, Infection and Immunity
Room: Bataan

Speaker 3 of 7
Marvin C. Gershengorn, National Institutes of Health, USA
Kaposi's Sarcoma-Associated Herpesvirus GPCR

Friday, February 20 | 8:00AM - 11:15AM
GPCRs in Olfaction, Infection and Immunity
Room: Bataan

Speaker 4 of 7
Marc Parmentier, Universite Libre de Bruxelles, Belgium
Functional Characterization of New Chemoattractant Receptors

Friday, February 20 | 8:00AM - 11:15AM
GPCRs in Olfaction, Infection and Immunity
Room: Bataan

Speaker 5 of 7
Rob Leurs, Vrije Universiteit Amsterdam, Netherlands
Constitutive Signaling of HCMV-Encoded G-Protein Coupled Receptors

Friday, February 20 | 8:00AM - 11:15AM
GPCRs in Olfaction, Infection and Immunity
Room: Bataan

Speaker 6 of 7
Vikas Bhandawat, Duke University, USA
Short Talk: Amplification by a Single GPCR Molecule in the Olfactory Receptor Neuron

Friday, February 20 | 8:00AM - 11:15AM
GPCRs in Olfaction, Infection and Immunity
Room: Bataan

Speaker 7 of 7
Takehiko Yokomizo, Juntendo University School of Medicine, Japan
Short Talk: In vitro and in vivo Roles of Leukotriene B4 Receptors

Friday, February 20 | 9:20AM - 9:40AM
Coffee Break
Room: Rio Grande C/D


Friday, February 20 | 11:15AM - 1:00PM
Poster Setup
Room: Rio Grande


Friday, February 20 | 1:00PM - 10:00PM
Poster Viewing
Room: Rio Grande


Friday, February 20 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Foyer


Friday, February 20 | 5:00PM - 7:00PM
Late Breaking Developments
Room: Bataan

Speaker 1 of 7
* Graeme Milligan, University of Glasgow, UK

Friday, February 20 | 5:00PM - 7:00PM
Late Breaking Developments
Room: Bataan

Speaker 2 of 7
Marie Terpager, University of Copenhagen, Denmark
Short Talk: Covalent Dimerization of 7TM Receptors

Friday, February 20 | 5:00PM - 7:00PM
Late Breaking Developments
Room: Bataan

Speaker 3 of 7
Douglas P. Gladue, Stony Brook University, USA
Short Talk: Application of a Novel Two Hybrid Assay for Analysis of G Protein Coupled Receptor Interaction in vivo

Friday, February 20 | 5:00PM - 7:00PM
Late Breaking Developments
Room: Bataan

Speaker 4 of 7
Annette Gilchrist, Midwestern University, USA
Short Talk: Identification of Small Molecules Targeting Thrombin Receptor – Gq Activation

Friday, February 20 | 5:00PM - 7:00PM
Late Breaking Developments
Room: Bataan

Speaker 5 of 7
Xuanmao Jiao, Thomas Jefferson University, USA
Short Talk: Ligand-Induced Dynamic Distribution of CXCR1 and its Signaling Revealed by Living Cell Fluorescence Imaging

Friday, February 20 | 5:00PM - 7:00PM
Late Breaking Developments
Room: Bataan

Speaker 6 of 7
Martin J. Stone, Monash University, Australia
Short Talk: Soluble Mimics of Chemokine Receptors

Friday, February 20 | 5:00PM - 7:00PM
Late Breaking Developments
Room: Bataan

Speaker 7 of 7
Marcel Hoffmann, Crystallics, Netherlands
Short Talk: Biology Driven Discovery of GPCR Targets Using Arrayed Adenoviral Gain or Loss of Function Libraries

Friday, February 20 | 7:00PM - 8:00PM
Social Hour
Room: Rio Grande


Friday, February 20 | 7:30PM - 10:00PM
Poster Session 3
Room: Rio Grande


Friday, February 20 | 8:00PM - 9:00PM
Cash Bar
Room: Rio Grande


Saturday, February 21 | 7:00AM - 8:00AM
Breakfast
Room: Rio Grande A/B/C


Saturday, February 21 | 8:00AM - 11:15AM
New Technologies to Study GPCRs Session Sponsored by Synapti
c Pharmaceutical Corporation, a Lundbeck Co.

Room: Bataan

Speaker 1 of 7
* Susan F. Steinberg, Columbia University, USA

Saturday, February 21 | 8:00AM - 11:15AM
New Technologies to Study GPCRs Session Sponsored by Synapti
c Pharmaceutical Corporation, a Lundbeck Co.

Room: Bataan

Speaker 2 of 7
Dianne M. Perez, Cleveland Clinic Foundation, USA
DNA Microarrays to Define Novel alpha1-AR Signaling Networks

Saturday, February 21 | 8:00AM - 11:15AM
New Technologies to Study GPCRs Session Sponsored by Synapti
c Pharmaceutical Corporation, a Lundbeck Co.

Room: Bataan

Speaker 3 of 7
Brian K. Kobilka, Stanford University School of Medicine, USA
Spectroscopic Approaches to Study Conformational Changes in GPCRs

Saturday, February 21 | 8:00AM - 11:15AM
New Technologies to Study GPCRs Session Sponsored by Synapti
c Pharmaceutical Corporation, a Lundbeck Co.

Room: Bataan

Speaker 4 of 7
Olivier Civelli, University of California, Irvine, USA
Unraveling the Identity of Orphan GPCRs

Saturday, February 21 | 8:00AM - 11:15AM
New Technologies to Study GPCRs Session Sponsored by Synapti
c Pharmaceutical Corporation, a Lundbeck Co.

Room: Bataan

Speaker 5 of 7
James Leonard, Janssen Pharmaceuticals, USA
Moving from Genes to Screens at GPCRs

Saturday, February 21 | 8:00AM - 11:15AM
New Technologies to Study GPCRs Session Sponsored by Synapti
c Pharmaceutical Corporation, a Lundbeck Co.

Room: Bataan

Speaker 6 of 7
Isabel D. Alves, University of Arizona, USA
Short Talk: Plasmon-Waveguide Resonance Spectroscopy: A Direct Method to Study Signal Transduction Events in GPCRs

Saturday, February 21 | 8:00AM - 11:15AM
New Technologies to Study GPCRs Session Sponsored by Synapti
c Pharmaceutical Corporation, a Lundbeck Co.

Room: Bataan

Speaker 7 of 7
Larry A. Sklar, University of New Mexico, USA
Short Talk: Flow Cytometric Analyses of GPCR Assemblies and their Potential Applications in Drug Discovery

Saturday, February 21 | 9:20AM - 9:40AM
Coffee Break
Room: Rio Grande C/D


Saturday, February 21 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Foyer


Saturday, February 21 | 5:00PM - 7:00PM
GPCR Genetic Variants in Human Disease
Room: Bataan

Speaker 1 of 5
* Paul A. Insel, University of California, San Diego, USA

Saturday, February 21 | 5:00PM - 7:00PM
GPCR Genetic Variants in Human Disease
Room: Bataan

Speaker 2 of 5
Stephen B. Liggett, USF Health Personalized Medicine Institute, USA
Adrenergic Receptor Polymorphisms: Function and Disease Associations

Saturday, February 21 | 5:00PM - 7:00PM
GPCR Genetic Variants in Human Disease
Room: Bataan

Speaker 3 of 5
Mariel Birnbaumer, NIEHS, National Institutes of Health, USA
V2R Mutations and Water Balance

Saturday, February 21 | 5:00PM - 7:00PM
GPCR Genetic Variants in Human Disease
Room: Bataan

Speaker 4 of 5
Stephen J. O'Brien, National Cancer Institute, National Institutes of Health, USA
Complex Multifactorial Gene Discovery in Man

Saturday, February 21 | 5:00PM - 7:00PM
GPCR Genetic Variants in Human Disease
Room: Bataan

Speaker 5 of 5
Brinda K. Rana, University of California, San Diego, USA
Short Talk: An Approach for Detecting Genetic Epistasis at GPCRs and their Effector Loci in Complex Disease

Saturday, February 21 | 7:00PM - 8:00PM
Social Hour
Room: Rio Grande


Saturday, February 21 | 8:00PM - 11:00PM
Entertainment
Room: Rio Grande


Saturday, February 21 | 8:00PM - 11:00PM
Cash Bar
Room: Rio Grande


Sunday, February 22 | 10:26AM - 10:26AM
Departure


*Session Chair.