Past Meeting | Keystone Symposia

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Cancer and Kinases: Lessons from the Clinic (2006C2)

Web Desc
Protein Kinases and Cancer: The Promise of Molecular-Based Therapies Organizer(s): Judith S. Sebolt-Leopold and Charles L. Sawyers Date: February 24 - 29, 2004 Location: Granlibakken Tahoe, Tahoe City, CA, USA Sponsored by Amgen Inc. Summary of Meeting: Upon completion of this conference, participants should be able to: - Discuss progress made in the cancer research community showing that kinases are druggable targets. - Recognize key signal transduction pathways amenable to pharmacological intervention by kinase inhibitors. - Discuss the critical importance of translational assays in driving clinical trial design of kinase-targeted therapies. - Discuss the application of technologies, encompassing proteomics, genomics, and structural biology, for facilitating novel drug discovery. - Discuss the challenges facing oncologists in deciphering the complexities of individual tumor signaling. - Integrate multidisciplinary leaders involved in basic research, pharmaceutical discovery, and clinical oncology in order to provide all with a better understanding of the numerous steps involved in going from bench to bedside. - Develop new collaborations among the scientists in attendance as well as new insights leading to novel and effective interventions. Discounted Abstract Deadline: October 23 2003 Discounted Registration Deadline: December 23 2003 We gratefully acknowledge additional support for this conference from: Cell Signaling Technology, Inc. We gratefully acknowledge the generous grant for this conference provided by: National Cancer Institute (NCI) Grant No. 1R13CA105863-01 We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

Protein Kinases and Cancer: The Promise of Molecular-Based Therapies

Organizer(s): Judith S. Sebolt-Leopold and Charles L. Sawyers

Date: February 24 - 29, 2004
Location: Granlibakken Tahoe, Tahoe City, CA, USA

Program


Tuesday, February 24 \| 3:00PM - 7:00PM Registration Room: Pre-Function
Tuesday, February 24 \| 7:15PM - 7:30PM Orientation Room: Mountain/Lake Rooms
Tuesday, February 24 \| 7:30PM - 8:30PM Keynote Address Room: Mountain/Lake Rooms Speaker 1 of 1 Robert E. Wittes, Memorial Sloan-Kettering Cancer Center, USA A Clinical Perspective on the Future of Kinase-Targeted Therapies
Wednesday, February 25 \| 7:00AM - 8:00AM Breakfast Room: Granhall
Wednesday, February 25 \| 8:00AM - 11:15AM Therapies Targeting Growth Factor Receptors: The ErbB Family and Associated Signaling Room: Mountain/Lake Rooms Speaker 1 of 6 * Carlos L. Arteaga, Vanderbilt University School of Medicine, USA Predictors of Response and Resistance to Erbb Tyrosine Kinase Inhibitors
Wednesday, February 25 \| 8:00AM - 11:15AM Therapies Targeting Growth Factor Receptors: The ErbB Family and Associated Signaling Room: Mountain/Lake Rooms Speaker 2 of 6 Lewis A. Chodosh, University of Pennsylvania School of Medicine, USA Inducible Transgenic Models for Breast Cancer Progression and Target Validation
Wednesday, February 25 \| 8:00AM - 11:15AM Therapies Targeting Growth Factor Receptors: The ErbB Family and Associated Signaling Room: Mountain/Lake Rooms Speaker 3 of 6 Mark X. Sliwkowski, Genentech, Inc., USA Targeting Ligand Activated ErbB2/HER2 in Solid Tumors
Wednesday, February 25 \| 8:00AM - 11:15AM Therapies Targeting Growth Factor Receptors: The ErbB Family and Associated Signaling Room: Mountain/Lake Rooms Speaker 4 of 6 Tomi K. Sawyer, CMD BIoscience, USA Novel Dual Src/Abl Kinase Inhibitors for Cancer Therapy
Wednesday, February 25 \| 8:00AM - 11:15AM Therapies Targeting Growth Factor Receptors: The ErbB Family and Associated Signaling Room: Mountain/Lake Rooms Speaker 5 of 6 Geoffrey W. Krystal, Virginia Commonwealth University, USA Short Talk: The Combination of STI571 and a Novel IGF-1R Kinase Inhibitor Efficiently Blocks PI3K-Akt Activity, Inhibits Growth and Promotes Apoptosis in SCLC
Wednesday, February 25 \| 8:00AM - 11:15AM Therapies Targeting Growth Factor Receptors: The ErbB Family and Associated Signaling Room: Mountain/Lake Rooms Speaker 6 of 6 Sang Hoon Lee, ABL Bio, South Korea Short Talk: In vivo Anti-Angiogenic and Anti-Tumor Activity is Associated with Target Modulation by CHIR258, a Small Molecule Inhibitor of Receptor Tyrosine Kinases
Wednesday, February 25 \| 9:20AM - 9:40AM Coffee Break Room: Pre-Function
Wednesday, February 25 \| 11:15AM - 1:00PM Poster Setup Room: Bay Room
Wednesday, February 25 \| 1:00PM - 10:00PM Poster Viewing Room: Bay Room
Wednesday, February 25 \| 4:30PM - 5:00PM Coffee & Snacks Available Room: Pre-Function
Wednesday, February 25 \| 5:00PM - 7:15PM Additional Kinase Approaches with Therapeutic Promise Room: Mountain/Lake Rooms Speaker 1 of 4 * Douglas Hanahan, ISREC, Switzerland An Overview of Angiogenic-Directed Approaches
Wednesday, February 25 \| 5:00PM - 7:15PM Additional Kinase Approaches with Therapeutic Promise Room: Mountain/Lake Rooms Speaker 2 of 4 George F. Vande Woude, Van Andel Research Institute, USA Met-HGF/SF in Human Malignancy
Wednesday, February 25 \| 5:00PM - 7:15PM Additional Kinase Approaches with Therapeutic Promise Room: Mountain/Lake Rooms Speaker 3 of 4 Anita B. Roberts, National Institutes of Health, USA TGF-beta/Smad Signaling: Dual Tumor Suppressor and Pro-Metastatic Activities
Wednesday, February 25 \| 5:00PM - 7:15PM Additional Kinase Approaches with Therapeutic Promise Room: Mountain/Lake Rooms Speaker 4 of 4 Jonathan M. Yingling, Idera Pharmaceuticals, Inc., USA TGF-beta Receptor Kinase Inhibitors: A Novel Cancer Therapy
Wednesday, February 25 \| 7:15PM - 8:15PM Dinner Room: Granhall
Wednesday, February 25 \| 8:00PM - 10:30PM Poster Session 1 Room: Bay Room
Wednesday, February 25 \| 8:00PM - 9:00PM Social Hour Room: Bay Room
Thursday, February 26 \| 7:00AM - 8:00AM Breakfast Room: Granhall
Thursday, February 26 \| 8:00AM - 11:00AM The MAP Kinase Pathway: Multiple Targets for Pharmacological Intervention Room: Mountain/Lake Rooms Speaker 1 of 5 Daniel G. Gioeli, University of Virginia, USA Signal Transduction in Prostate Cancer Progression
Thursday, February 26 \| 8:00AM - 11:00AM The MAP Kinase Pathway: Multiple Targets for Pharmacological Intervention Room: Mountain/Lake Rooms Speaker 2 of 5 * Judith Sebolt-Leopold, USA Attractiveness of Targeting MEK for Anticancer Drug Development
Thursday, February 26 \| 8:00AM - 11:00AM The MAP Kinase Pathway: Multiple Targets for Pharmacological Intervention Room: Mountain/Lake Rooms Speaker 3 of 5 Richard M. Marais, Cancer Research UK Manchester Institute, UK B-Raf Mutations in Human Cancer: Implications for Development of Improved Therapies
Thursday, February 26 \| 8:00AM - 11:00AM The MAP Kinase Pathway: Multiple Targets for Pharmacological Intervention Room: Mountain/Lake Rooms Speaker 4 of 5 Michelle Renee Ward, Chiron Corporation, USA Short Talk: Amplification of B-raf in Melanoma Cell Lines Identified Using Array Comparative Genomic Hybridization (aCGH)
Thursday, February 26 \| 8:00AM - 11:00AM The MAP Kinase Pathway: Multiple Targets for Pharmacological Intervention Room: Mountain/Lake Rooms Speaker 5 of 5 Rosalie C. Sears, Oregon Health & Science University, USA Short Talk: c-Myc Protein Degradation is Regulated by Ras Signaling Pathways, the PP2A Phosphatase and the Pin1 Prolyl Isomerase
Thursday, February 26 \| 9:20AM - 9:40AM Coffee Break Room: Pre-Function
Thursday, February 26 \| 11:00AM - 1:00PM Poster Setup Room: Bay Room
Thursday, February 26 \| 1:00PM - 10:00PM Poster Viewing Room: Bay Room
Thursday, February 26 \| 4:30PM - 5:00PM Coffee & Snacks Available Room: Pre-Function
Thursday, February 26 \| 5:00PM - 7:00PM Cell Cycle Targets Room: Mountain/Lake Rooms Speaker 1 of 4 * Edward Harlow, Constellation Pharmaceuticals, USA Synergy between Signaling Pathways
Thursday, February 26 \| 5:00PM - 7:00PM Cell Cycle Targets Room: Mountain/Lake Rooms Speaker 2 of 4 Peter L. Toogood, Lycera Corporation, USA Discovery of A Selective CDK4 Inhibitor
Thursday, February 26 \| 5:00PM - 7:00PM Cell Cycle Targets Room: Mountain/Lake Rooms Speaker 3 of 4 Nicholas J. Keen, Novartis Institutes for BioMedical Research, USA Targeting Cytokinesis and the Cell Cycle: Aurora B and CDK1/2 as Unique Targets in Cancer
Thursday, February 26 \| 5:00PM - 7:00PM Cell Cycle Targets Room: Mountain/Lake Rooms Speaker 4 of 4 Martin J.I. Andrews, Cyclacel, Ltd., UK Short Talk: Inhibition of CDK2- Cyclin A Activity by Blocking Substrate Recruitment
Thursday, February 26 \| 7:00PM - 8:00PM Dinner Room: Bay Room
Thursday, February 26 \| 8:00PM - 10:30PM Poster Session 2 Room: Bay Room
Thursday, February 26 \| 8:00PM - 9:00PM Social Hour Room: Bay Room
Friday, February 27 \| 7:00AM - 8:00AM Breakfast Room: Granhall
Friday, February 27 \| 8:00AM - 11:15AM Survival Signaling: The AKT/PI 3-Kinase Pathway Room: Mountain/Lake Rooms Speaker 1 of 5 Gordon B. Mills, University of Texas MD Anderson Cancer Center, USA Targeting the PI3K Pathway in Cancer
Friday, February 27 \| 8:00AM - 11:15AM Survival Signaling: The AKT/PI 3-Kinase Pathway Room: Mountain/Lake Rooms Speaker 2 of 5 Philip N. Tsichlis, Tufts-New England Medical Center, USA TPL-2 on a Cancer Target
Friday, February 27 \| 8:00AM - 11:15AM Survival Signaling: The AKT/PI 3-Kinase Pathway Room: Mountain/Lake Rooms Speaker 3 of 5 * Neal Rosen, Memorial Sloan-Kettering Cancer Center, USA Inhibition of AKT Activation with Ansamycins
Friday, February 27 \| 8:00AM - 11:15AM Survival Signaling: The AKT/PI 3-Kinase Pathway Room: Mountain/Lake Rooms Speaker 4 of 5 Paul Workman, Institute of Cancer Research, UK Drugging the Cancer Chaperone: Laboratory and Clinical Advances in Targeting Heat Shock Protein 90 (Hsp90)
Friday, February 27 \| 8:00AM - 11:15AM Survival Signaling: The AKT/PI 3-Kinase Pathway Room: Mountain/Lake Rooms Speaker 5 of 5 Jeremy R. Graff, Eli Lilly and Company, USA Short Talk: Anti-Tumor Activity of the PKCbeta Selective Inhibitor, LY317615: Inhibition of the PI3 Kinase/ AKT Pathway by the Primary Metabolite, LY326020
Friday, February 27 \| 9:20AM - 9:40AM Coffee Break Room: Pre-Function
Friday, February 27 \| 11:15AM - 1:00PM Poster Setup Room: Bay Room
Friday, February 27 \| 1:00PM - 10:00PM Poster Viewing Room: Bay Room
Friday, February 27 \| 4:30PM - 5:00PM Coffee & Snacks Available Room: Pre-Function
Friday, February 27 \| 5:00PM - 7:00PM Survival Signaling: Inhibition of mTOR(FRAP) Room: Mountain/Lake Rooms Speaker 1 of 4 * Manuel Hidalgo, Johns Hopkins School of Medicine, USA Overview of mTOR Biology and Therapeutic Approaches
Friday, February 27 \| 5:00PM - 7:00PM Survival Signaling: Inhibition of mTOR(FRAP) Room: Mountain/Lake Rooms Speaker 2 of 4 Pamela S. Cohen, Amo Therapeutics, USA The Clinical Promise of mTOR Targeted Therapy
Friday, February 27 \| 5:00PM - 7:00PM Survival Signaling: Inhibition of mTOR(FRAP) Room: Mountain/Lake Rooms Speaker 3 of 4 James J. Gibbons Jr., Wyeth Pharmaceuticals, USA Enhanced Sensitivity of PTEN-Deficient Tumors to mTOR Inhibition
Friday, February 27 \| 5:00PM - 7:00PM Survival Signaling: Inhibition of mTOR(FRAP) Room: Mountain/Lake Rooms Speaker 4 of 4 Amy M. Mingo-Sion, University of Colorado Health Sciences Center, USA Short Talk: Mammalian Target of Rapamycin Predominantly Regulates Insulin Receptor Substrate-1 Ser312 Phosphorylation in Breast Cancer Cells
Friday, February 27 \| 7:00PM - 8:00PM Dinner Room: Granhall
Friday, February 27 \| 8:00PM - 10:30PM Poster Session 3 Room: Bay Room
Friday, February 27 \| 8:00PM - 9:00PM Social Hour Room: Bay Room
Saturday, February 28 \| 7:00AM - 8:00AM Breakfast Room: Granhall
Saturday, February 28 \| 8:00AM - 11:15AM Impact of Technologies on Future Target Identification Room: Mountain/Lake Rooms Speaker 1 of 6 John Kuriyan, University of California, Berkeley, USA Auto-Regulation Mechanisms in c-Abl Tyrosine Kinase
Saturday, February 28 \| 8:00AM - 11:15AM Impact of Technologies on Future Target Identification Room: Mountain/Lake Rooms Speaker 2 of 6 Keith P. Wilson, Takeda California, USA Structures of Active Autoinhibited and Gleeve-Bond C-KIT
Saturday, February 28 \| 8:00AM - 11:15AM Impact of Technologies on Future Target Identification Room: Mountain/Lake Rooms Speaker 3 of 6 Natalie G. Ahn, University of Colorado, USA A Functional Proteomics Approach to Target Identification
Saturday, February 28 \| 8:00AM - 11:15AM Impact of Technologies on Future Target Identification Room: Mountain/Lake Rooms Speaker 4 of 6 * William R. Sellers, Broad Institute of MIT and Harvard, USA Phenotypic Screening of Small Molecule Libraries
Saturday, February 28 \| 8:00AM - 11:15AM Impact of Technologies on Future Target Identification Room: Mountain/Lake Rooms Speaker 5 of 6 X. Helen Hua, Enfunding Solution Inc, USA Short Talk: Enhancing Discovery of Selective Small Molecule Akt Inhibitors Using Biomarkers
Saturday, February 28 \| 8:00AM - 11:15AM Impact of Technologies on Future Target Identification Room: Mountain/Lake Rooms Speaker 6 of 6 J. Guillermo Paez, Dana Farber Cancer Institute, USA Short Talk: Kinome Re-Sequencing in Human Cancer
Saturday, February 28 \| 9:00AM - 12:00PM Entertainment Room: Mountain/Lake Rooms
Saturday, February 28 \| 9:20AM - 9:40AM Coffee Break Room: Pre-Function
Saturday, February 28 \| 4:30PM - 5:00PM Coffee & Snacks Available Room: Pre-Function
Saturday, February 28 \| 5:00PM - 7:00PM Looking Forward: The Impact of Kinase-Targeted Therapies on Patient Survival Room: Mountain/Lake Rooms Speaker 1 of 3 Roger G. Ulrich, RUC Pharmaceutical Development Specialists, USA Molecular Profiling of Adverse Drug Effects
Saturday, February 28 \| 5:00PM - 7:00PM Looking Forward: The Impact of Kinase-Targeted Therapies on Patient Survival Room: Mountain/Lake Rooms Speaker 2 of 3 Christopher E. Sims, University of California, Irvine, USA Short Talk: Advancing the Field of Signal Transduction One Cell at a Time: Analysis of Single Tumor Cells Using the Laser Micropipet System
Saturday, February 28 \| 5:00PM - 7:00PM Looking Forward: The Impact of Kinase-Targeted Therapies on Patient Survival Room: Mountain/Lake Rooms Speaker 3 of 3 * Charles L. Sawyers, Memorial Sloan-Kettering Cancer Center, USA Clinical Reality: How do Oncologists Screen for Signaling Abnormalities?
Saturday, February 28 \| 7:00PM - 8:00PM Social Hour Room: Granhall
Saturday, February 28 \| 8:00PM - 9:00PM Dinner Room: Mountain/Lake Rooms
Sunday, February 29 \| 10:26AM - 10:26AM Departure *Session Chair.