Web Desc
Mast Cells in Physiology, Host Defense and Disease: Beyond IgE
Organizer(s): Melissa A. Brown, K. Frank Austen and Stephen J. Galli
Date: February 28 - March 04, 2004
Location: Sagebrush Inn & Suites, Taos, NM, USA
Sponsored in part by the Director's Sponsor Fund
Summary of Meeting:
Mast cells are critical effector cells in acute allergic reactions. In this setting, mast cell activation by antigen-dependent cross-linking of high affinity receptors for IgE (FcepsilonRI) induces the release of preformed molecules (such as histamine), as well as the synthesis and release of cytokines, chemokines, growth factors, leukotrienes and prostaglandins. However, mast cell functions can also be elicited by immune complexes, complement products, neuropeptides, cytokines and ligands of toll-like receptors. Accordingly, the proven or potential functions of mast cells include diverse, IgE-independent roles in host defense and disease (including autoimmune or cardiovascular disorders) as well as in physiological processes, such as regulation of epithelial barrier function and modulation of nerve function. This conference will assess what is currently known about the roles of mast cells and will consider how our understanding can be advanced by the application of new technologies and approaches to analyze and manipulate mast cell function.
Discounted Abstract Deadline: October 28 2003
Discounted Registration Deadline: December 29 2003
We gratefully acknowledge additional support for this conference from:
GlaxoSmithKline Research & Development, Ltd.
UCB Reseach/ UCB Pharma
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI058260-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program
Saturday, February 28 | 3:00PM - 7:00PM
Registration
Room: Chamisa Lobby
Saturday, February 28 | 6:15PM - 7:15PM
Refreshments
Room: Chamisa Lobby
Saturday, February 28 | 7:15PM - 7:30PM
Orientation
Room: Chamisa Ballroom 1
Sunday, February 29 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros
Sunday, February 29 | 8:00AM - 11:00AM
Mast Cell Development/Migration and in vivo Models I. Sessi
on Sponsored in part by GlaxoSmithKline Research & Development Ltd.

Room: Chamisa Ballroom 1

Speaker 1 of 5
Dean D. Metcalfe, NIAID, National Institutes of Health, USA
Regulation of Normal and Neoplastic Human Mast Cell Development
Sunday, February 29 | 8:00AM - 11:00AM
Mast Cell Development/Migration and in vivo Models I. Sessi
on Sponsored in part by GlaxoSmithKline Research & Development Ltd.

Room: Chamisa Ballroom 1

Speaker 2 of 5
Cheryl A. London, Ohio State University, USA
Canine Mast Cell Tumors: Role of C-Kit Mutations and Treatment with Kit Inhibitors
Sunday, February 29 | 8:00AM - 11:00AM
Mast Cell Development/Migration and in vivo Models I. Sessi
on Sponsored in part by GlaxoSmithKline Research & Development Ltd.

Room: Chamisa Ballroom 1

Speaker 3 of 5
* Stephen J. Galli, Stanford University, USA
Mast Cell Reconstitution of Genetically Mast-Cell-Deficient c-kit Mutant Mice as a Model for Investigating Mast Cell Biology in vivo: Insights into the Roles of Mast Cells in Health and Disease
Sunday, February 29 | 8:00AM - 11:00AM
Mast Cell Development/Migration and in vivo Models I. Sessi
on Sponsored in part by GlaxoSmithKline Research & Development Ltd.

Room: Chamisa Ballroom 1

Speaker 4 of 5
Yukihiko Kitamura, Osaka University Medical School, Japan
Regulation of Mouse Mast Cell Development by MITF
Sunday, February 29 | 8:00AM - 11:00AM
Mast Cell Development/Migration and in vivo Models I. Sessi
on Sponsored in part by GlaxoSmithKline Research & Development Ltd.

Room: Chamisa Ballroom 1

Speaker 5 of 5
Jakub Abramson, Weizmann Institute of Science, Israel
Short Talk: Dok-1 – A Novel Control Element of the Late Mast Cell Secretory Response
Sunday, February 29 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby
Sunday, February 29 | 11:00AM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 2
Sunday, February 29 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 2
Sunday, February 29 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Chamisa Lobby
Sunday, February 29 | 5:00PM - 7:15PM
Mast Cell Development/Migration and in vivo Models II
Room: Chamisa Ballroom 1

Speaker 1 of 4
Shigeo Koyasu, Keio University School of Medicine, Japan
Role of Phosphoinositide 3-Kinase in Differentiation and Function of Mast Cells
Sunday, February 29 | 5:00PM - 7:15PM
Mast Cell Development/Migration and in vivo Models II
Room: Chamisa Ballroom 1

Speaker 2 of 4
Richard L. Stevens, Brigham and Women's Hospital, USA
Regulation of Mast Cell Maturation by RasGRP4
Sunday, February 29 | 5:00PM - 7:15PM
Mast Cell Development/Migration and in vivo Models II
Room: Chamisa Ballroom 1

Speaker 3 of 4
Michael F. Gurish, Brigham and Women's Hospital, Harvard Medical School, USA
Mast Cell Progenitor Trafficking and Expansion
Sunday, February 29 | 5:00PM - 7:15PM
Mast Cell Development/Migration and in vivo Models II
Room: Chamisa Ballroom 1

Speaker 4 of 4
* Hugh R.P. Miller, University of Edinburgh, UK
Role of TGF-b1 in the Regulation of Mast Cell Development, Phenotype and Integrin Expression
Sunday, February 29 | 7:15PM - 8:15PM
Social Hour
Room: Chamisa Ballroom 2
Sunday, February 29 | 7:30PM - 10:00PM
Poster Session 1: Mast Cell Development/Migration and in viv
o Models
Room: Chamisa Ballroom 2
Monday, March 01 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros
Monday, March 01 | 8:00AM - 11:00AM
Positive and Negative Regulation of Mast Cell Function
Room: Chamisa Ballroom 1

Speaker 1 of 5
* Jean-Pierre Kinet, Beth Israel Deaconess Medical Center and Harvard Medical School, USA
Regulation of Mast Cell Activation via FcepsilonRI
Monday, March 01 | 8:00AM - 11:00AM
Positive and Negative Regulation of Mast Cell Function
Room: Chamisa Ballroom 1

Speaker 2 of 5
Howard R. Katz, Brigham and Women's Hospital, Harvard Medical School, USA
Regulation of Adaptive and Innate Inflammation by the gp49B1 Inhibitory Receptor
Monday, March 01 | 8:00AM - 11:00AM
Positive and Negative Regulation of Mast Cell Function
Room: Chamisa Ballroom 1

Speaker 3 of 5
Beverly Koller, University of North Carolina at Chapel Hill, USA
Role of G Protein-Coupled Receptors in Regulation of Mast Cell Function
Monday, March 01 | 8:00AM - 11:00AM
Positive and Negative Regulation of Mast Cell Function
Room: Chamisa Ballroom 1

Speaker 4 of 5
Ehud Razin, Hebrew University, Hadassah Medical School, Israel
Short Talk: A Novel Function of Lysyl-tRNA Synthetase, Diadenosine Tetraphospate (Ap4A) and STAT3 as Regulators of the Activity of Microphthalmia Transcription Factor in Activated Mast Cells
Monday, March 01 | 8:00AM - 11:00AM
Positive and Negative Regulation of Mast Cell Function
Room: Chamisa Ballroom 1

Speaker 5 of 5
Frank A. Redegeld, University of Utrecht, Netherlands
Mast Cell Sensitizing Immunoglobulin Light Chains in Immediate and Delayed Hypersensitivity Reactions
Monday, March 01 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby
Monday, March 01 | 11:00AM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 2
Monday, March 01 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 2
Monday, March 01 | 2:00PM - 4:00PM
Workshop 1: Identification and Characterization of Mast Cell
Products
Room: Chamisa Ballroom 1

Speaker 1 of 6
Hirohisa Saito, National Research Institute for Child Health and Development, Japan
Transcriptome Profiling of Various Mast Cell Types
Monday, March 01 | 2:00PM - 4:00PM
Workshop 1: Identification and Characterization of Mast Cell
Products
Room: Chamisa Ballroom 1

Speaker 2 of 6
* Karl H. Nocka, Pfizer, USA
Searching for Therapeutic Targets in Human Mast Cells
Monday, March 01 | 2:00PM - 4:00PM
Workshop 1: Identification and Characterization of Mast Cell
Products
Room: Chamisa Ballroom 1

Speaker 3 of 6
Sue M. Liu, Garvan Institute of Medical Research, Australia
Discovery of Novel Inflammatory Mast Cell Genes
Monday, March 01 | 2:00PM - 4:00PM
Workshop 1: Identification and Characterization of Mast Cell
Products
Room: Chamisa Ballroom 1

Speaker 4 of 6
Amos Baruch, Genentech, Inc., USA
Identification and Characterization of Mast Cell Membrane and Secreted Hydrolases Using a Novel Functional Proteomics Approach
Monday, March 01 | 2:00PM - 4:00PM
Workshop 1: Identification and Characterization of Mast Cell
Products
Room: Chamisa Ballroom 1

Speaker 5 of 6
Anna Di Nardo, University of California, San Diego, USA
Expression and Function of Cathelicidin Antimicrobial Peptide in Mast Cells
Monday, March 01 | 2:00PM - 4:00PM
Workshop 1: Identification and Characterization of Mast Cell
Products
Room: Chamisa Ballroom 1

Speaker 6 of 6
Christine Möller, Uppsala University, Sweden
Stem Cell Factor Regulates Mast Cell Survival via Forkhead and MEK Regulated Expression and Phosphorylation of the BH3-only Pro-apoptotic Protein Bim
Monday, March 01 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Chamisa Lobby
Monday, March 01 | 5:00PM - 7:15PM
Mast Cells in Inflammation and Host Defense
Room: Chamisa Ballroom 1

Speaker 1 of 4
* K. Frank Austen, Harvard Medical School, USA
Generation of cysLTs by Mast Cells in situ - The Receptor-Mediated Action of cysLTs in situ - And the Receptors-Mediated Action of cysLTs on Human Mast Cells in vitro
Monday, March 01 | 5:00PM - 7:15PM
Mast Cells in Inflammation and Host Defense
Room: Chamisa Ballroom 1

Speaker 2 of 4
Jean S. Marshall, Dalhousie University, Canada
Selective Mediator Production by Mast Cells in Response to Pathogens and their Products
Monday, March 01 | 5:00PM - 7:15PM
Mast Cells in Inflammation and Host Defense
Room: Chamisa Ballroom 1

Speaker 3 of 4
Soman N. Abraham, Duke University Medical Center, USA
Mast Cells in Host Defense Against Bacteria
Monday, March 01 | 5:00PM - 7:15PM
Mast Cells in Inflammation and Host Defense
Room: Chamisa Ballroom 1

Speaker 4 of 4
Massimo Triggiani, University of Naples Federico II, Italy
Activation of Human Basophils and Mast Cells by Viral and Bacterial Products
Monday, March 01 | 7:15PM - 8:15PM
Social Hour
Room: Chamisa Ballroom 2
Monday, March 01 | 7:30PM - 10:00PM
Poster Session 2: Mast Cell Products and Regulation of Mast
Cell Activation
Room: Chamisa Ballroom 2
Tuesday, March 02 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros
Tuesday, March 02 | 8:00AM - 11:00AM
Roles of Mast Cells in Non-Allergic Disorders I
Room: Chamisa Ballroom 1

Speaker 1 of 5
* Melissa A. Brown, Northwestern University, USA
The Role of Mast Cells in EAE, a Rodent Model of Multiple Sclerosis
Tuesday, March 02 | 8:00AM - 11:00AM
Roles of Mast Cells in Non-Allergic Disorders I
Room: Chamisa Ballroom 1

Speaker 2 of 5
Diane Mathis, Harvard Medical School, USA
A Mast Cell-Dependent Model of Autoimmune Arthritis
Tuesday, March 02 | 8:00AM - 11:00AM
Roles of Mast Cells in Non-Allergic Disorders I
Room: Chamisa Ballroom 1

Speaker 3 of 5
J. Bruce Sundstrom, NIAID, National Institutes of Health, USA
Short Talk: Human Mast Cells as Potential Reservoirs for Persistent HIV-1 Infection
Tuesday, March 02 | 8:00AM - 11:00AM
Roles of Mast Cells in Non-Allergic Disorders I
Room: Chamisa Ballroom 1

Speaker 4 of 5
Zhi Liu, University of North Carolina at Chapel Hill, USA
Role of Mast Cells in Experimental Autoimmune Bullous Pemphigoid
Tuesday, March 02 | 8:00AM - 11:00AM
Roles of Mast Cells in Non-Allergic Disorders I
Room: Chamisa Ballroom 1

Speaker 5 of 5
Philip W. Askenase, Yale University School of Medicine, USA
How Mast Cells are Activated in T Cell Immunity: Invariant Valpha14+ Jalpha18+ NKT Cells and B-1 Cells begin the Initiating Cascade
Tuesday, March 02 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby
Tuesday, March 02 | 11:00AM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 2
Tuesday, March 02 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 2
Tuesday, March 02 | 2:00PM - 4:00PM
Workshop 2: Approaches for the Analysis of Mast Cell Functio
n in vivo
Room: Chamisa Ballroom 1

Speaker 1 of 8
* Stephen J. Galli, Stanford University, USA
Tuesday, March 02 | 2:00PM - 4:00PM
Workshop 2: Approaches for the Analysis of Mast Cell Functio
n in vivo
Room: Chamisa Ballroom 1

Speaker 2 of 8
Peter Bradding, University of Leicester Medical School, UK
The Anatomical Distribution of Mast Cells in the Airway of Asthmatics: Functional Implications
Tuesday, March 02 | 2:00PM - 4:00PM
Workshop 2: Approaches for the Analysis of Mast Cell Functio
n in vivo
Room: Chamisa Ballroom 1

Speaker 3 of 8
Michele Grimbaldeston, Centre for Cancer Biology, Australia
Mast-Cell-Deficient W-sash c-kit Mutant KitW-sh/KitW-sh Mice as
a Model for Investigating Mast Cell Biology In Vivo
Tuesday, March 02 | 2:00PM - 4:00PM
Workshop 2: Approaches for the Analysis of Mast Cell Functio
n in vivo
Room: Chamisa Ballroom 1

Speaker 4 of 8
John M. Hwang, University of Calgary, Canada
Mast Cells Modulate the TH-Cell Inflammatory Response in Cutaneous Contact Sensitivity
Tuesday, March 02 | 2:00PM - 4:00PM
Workshop 2: Approaches for the Analysis of Mast Cell Functio
n in vivo
Room: Chamisa Ballroom 1

Speaker 5 of 8
Anneke Rijnierse, Utrecht University, Netherlands
The Regulatory Role of Mast Cells in a Murine Model for Inflammatory Bowel Disease
Tuesday, March 02 | 2:00PM - 4:00PM
Workshop 2: Approaches for the Analysis of Mast Cell Functio
n in vivo
Room: Chamisa Ballroom 1

Speaker 6 of 8
Kelly Monk, Oregon Health & Science University, USA
Role of Mast Cells in Neurofibromatosis Type I
Tuesday, March 02 | 2:00PM - 4:00PM
Workshop 2: Approaches for the Analysis of Mast Cell Functio
n in vivo
Room: Chamisa Ballroom 1

Speaker 7 of 8
Feng-Chun Yang, Indiana University School of Medicine, USA
Loss of the Nf1 Tumor Suppressor Gene in Schwann Cells Provides a Potent Stimulus for Mast Cell Migration Via Secretion of Soluble Kit Ligand
Tuesday, March 02 | 2:00PM - 4:00PM
Workshop 2: Approaches for the Analysis of Mast Cell Functio
n in vivo
Room: Chamisa Ballroom 1

Speaker 8 of 8
Maike K. Knackstedt, Charité, Germany
Key Role of Mast Cells in Stress-Mediated Hair Loss
Tuesday, March 02 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Chamisa Lobby
Tuesday, March 02 | 5:00PM - 7:00PM
Roles of Mast Cells in Non-Allergic Disorders II
Room: Chamisa Ballroom 1

Speaker 1 of 4
Vanessa Ott, Promega, USA
Role of LTB4 in Mast Cell-Induced T Cell Recruitment
Tuesday, March 02 | 5:00PM - 7:00PM
Roles of Mast Cells in Non-Allergic Disorders II
Room: Chamisa Ballroom 1

Speaker 2 of 4
* Petri T. Kovanen, Wihuri Research Institute, Finland
Mast Cells in Atherogenesis and its Implications
Tuesday, March 02 | 5:00PM - 7:00PM
Roles of Mast Cells in Non-Allergic Disorders II
Room: Chamisa Ballroom 1

Speaker 3 of 4
Akira Matsumori, Kyoto University, Japan
Contribution of Mast Cells in the Development of Congestive Heart Failure
Tuesday, March 02 | 5:00PM - 7:00PM
Roles of Mast Cells in Non-Allergic Disorders II
Room: Chamisa Ballroom 1

Speaker 4 of 4
Karin E. de Visser, Netherlands Cancer Institute, Netherlands
Short Talk: The Role of the Adaptive Immune System in Mast Cell Potentiation of Cancer Development
Tuesday, March 02 | 7:00PM - 8:00PM
Social Hour
Room: Chamisa Ballroom 2
Tuesday, March 02 | 7:30PM - 10:00PM
Poster Session 3: Roles of Mast Cells in Health and Disease
Room: Chamisa Ballroom 2
Wednesday, March 03 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros
Wednesday, March 03 | 8:00AM - 9:20AM
Role of Mast Cells in Non-Allergic Disorders III
Room: Chamisa Ballroom 1

Speaker 1 of 2
* Barry K. Wershil, Albert Einstein College of Medicine, USA
Role of Neuropeptides and Mast Cells in a Mouse Model of Interstitial Cystitis
Wednesday, March 03 | 8:00AM - 9:20AM
Role of Mast Cells in Non-Allergic Disorders III
Room: Chamisa Ballroom 1

Speaker 2 of 2
Juan Pablo Abonia, Brigham and Women's Hospital, USA
Short Talk: Mast Cell Activation Releases Mouse Mast Cell Protease-5 during Ischemia-Reperfusion which Mediates Cytotoxic Injury of Skeletal Muscle
Wednesday, March 03 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby
Wednesday, March 03 | 9:40AM - 11:00AM
Role of Mast Cells in Physiology and Homeostasis I
Room: Chamisa Ballroom 1

Speaker 1 of 3
* George H. Caughey, University of California, San Francisco, USA
Structure and Function of Mast Cell Serine Proteases
Wednesday, March 03 | 9:40AM - 11:00AM
Role of Mast Cells in Physiology and Homeostasis I
Room: Chamisa Ballroom 1

Speaker 2 of 3
Magnus Åbrink, Uppsala University, Sweden
Short Talk: Insights Into Mast Cell Function Based on Analyses of
mMCP-4 -/- and NDST-2 -/- Mice
Wednesday, March 03 | 9:40AM - 11:00AM
Role of Mast Cells in Physiology and Homeostasis I
Room: Chamisa Ballroom 1

Speaker 3 of 3
Bradley J. Undem, Johns Hopkins University, USA
Mast Cell-Sensory Nerve Interactions
Wednesday, March 03 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Chamisa Lobby
Wednesday, March 03 | 5:00PM - 7:15PM
Roles of Mast Cells in Physiology and Homeostasis II
Room: Chamisa Ballroom 1

Speaker 1 of 4
* Mary H. Perdue, McMaster University, Canada
Regulation of Mucosal Barrier Function by Mast Cells
Wednesday, March 03 | 5:00PM - 7:15PM
Roles of Mast Cells in Physiology and Homeostasis II
Room: Chamisa Ballroom 1

Speaker 2 of 4
Itsuro Matsumoto, Nagasaki University School of Medicine, Japan
Hypothesis Regarding the Physiological Role of Mast Cells Located in the Median Eminence in the Regulation of the Hypothalamic-Pituitary-Adrenal Response
Wednesday, March 03 | 5:00PM - 7:15PM
Roles of Mast Cells in Physiology and Homeostasis II
Room: Chamisa Ballroom 1

Speaker 3 of 4
Rae Silver, Columbia University, USA
Mast Cells in the Brain
Wednesday, March 03 | 5:00PM - 7:15PM
Roles of Mast Cells in Physiology and Homeostasis II
Room: Chamisa Ballroom 1

Speaker 4 of 4
Marcus Maurer, Charité - Universitätsmedizin Berlin, Germany
IL-15 Inhibits Mast Cell-Dependent Innate Immune Defense Against Bacteria
Wednesday, March 03 | 7:15PM - 8:15PM
Social Hour
Room: Chamisa Ballroom 2
Wednesday, March 03 | 8:00PM - 11:00PM
Entertainment
Room: Chamisa Ballroom 2
Wednesday, March 03 | 8:15PM - 11:00PM
Cash Bar
Room: Chamisa Ballroom 2
Thursday, March 04 | 10:26AM - 10:26AM
Departure


*Session Chair.