Web Desc
Regulatory/Suppressor T Cells
Organizer(s): Ethan M. Shevach and Luciano Adorini
Date: March 10 - 15, 2004
Location: Banff Centre, Banff, Alberta, Canada
Sponsored in part by the Director's Sponsor Fund
For important information on the coronavirus, please click here
Summary of Meeting:
Although the concept of suppression mediated by T lymphocytes was originally proposed more than 30 years ago, recent studies in animal models of autoimmunity have rekindled interest in the existence of a subset of lymphocytes that specifically suppress immune responses. One population of naturally-occurring or endogenous T suppressor cells can be identified by co-expression of the CD4 and CD25 antigens. These cells suppress the activation of CD4 and CD8 T cells in vitro by an unknown cell-contact dependent mechanism. In vivo, these cells suppress autoimmune disease by both cell contact-dependent and suppressor cytokine-dependent pathways. Although these cells were originally described in the mouse, a population with identical phenotypic and functional properties has been identified in man. A second group of suppressor cells can be induced in vivo by oral exposure to antigen, by culture of T cells with cytokines (IL-10), or by pharmacologic manipulation of dendritic cell functions. These antigen-induced suppressors primarily inhibit T cell activation in vitro and in vivo by secreting suppressor cytokines. Determination of the cellular target and the molecular basis of CD4+CD25+ mediated suppression is a major area of current research. The nature of the physiologic ligand recognized by these cells is also unknown as is the breadth of their T cell repertoire. Suppressor/regulatory T cells have primarily been shown to inhibit animal models of autoimmune disease. However, recent studies have extended their range of activities to inhibition of tumor immunity, graft rejection, allergic disease, graft versus host disease, and acute and chronic infectious diseases. One critical area of future study will involve the development of protocols to enhance regulatory T cell function in vivo by pharmacologic means as such an approach should prove useful in autoimmunity, allergic disease, and graft rejection. Similarly, a related area will involve inhibition of regulatory T cell function, either transiently or permanently, by pharmacologic manipulation or treatment of animals or man with monoclonal antibodies specific for effector molecules on these cells. Protocols are now being developed for the adoptive immunotherapy of both CD4+CD25+ T cells that have been expanded in vitro and for suppressor cells that have been induced in vitro. These cells will be administered to patients with GVHD, graft rejection, and organ-specific and systemic autoimmune disease. This meeting will review all of the above issues and focus on the manipulation of regulatory T cell function in animal models of human disease as well as in disease in man.
Discounted Abstract Deadline: November 10 2003
Discounted Registration Deadline: January 12 2004
We gratefully acknowledge additional support for this conference from:
JDRFNational Multiple Sclerosis Society
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA105864-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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Program

Wednesday, March 10 | 3:00PM - 7:00PM
Registration
Room: Eric Harvie Foyer


Wednesday, March 10 | 6:15PM - 7:15PM
Refreshments
Room: Eric Harvie Foyer


Wednesday, March 10 | 7:15PM - 7:30PM
Orientation
Room: Eric Harvie Theatre


Wednesday, March 10 | 7:30PM - 8:30PM
Keynote Address
Room: Eric Harvie Theatre

Speaker 1 of 2
* Ethan M. Shevach, NIAID, National Institutes of Health, USA

Wednesday, March 10 | 7:30PM - 8:30PM
Keynote Address
Room: Eric Harvie Theatre

Speaker 2 of 2
Ronald N. Germain, NIAID, National Institutes of Health, USA
From Ts and I-J to Treg and CD25: From the Desert to the Promised Land?

Thursday, March 11 | 7:00AM - 8:00AM
Breakfast
Room: Donald Cameron Hall


Thursday, March 11 | 8:00AM - 11:00AM
CD4+CD25+ T Cells: Properties and Function
Room: Eric Harvie Theatre

Speaker 1 of 5
* Shimon Sakaguchi, Osaka University, Japan
Naturally Arising CD25+CD4+ Regulatory T Cells in Immunologic Tolerance: Foxp3, GiTR, IL-2/CO25 in Autoimmune Disease

Thursday, March 11 | 8:00AM - 11:00AM
CD4+CD25+ T Cells: Properties and Function
Room: Eric Harvie Theatre

Speaker 2 of 5
Jocelyne Demengeot, Instituto Gulbenkian de Ciencia, Portugal
Function and Dynamic of Regulatory T Cells during Inflammatory Responses

Thursday, March 11 | 8:00AM - 11:00AM
CD4+CD25+ T Cells: Properties and Function
Room: Eric Harvie Theatre

Speaker 3 of 5
Ethan M. Shevach, NIAID, National Institutes of Health, USA
CD4+CD25+ T Cells: Regulating the Regulator

Thursday, March 11 | 8:00AM - 11:00AM
CD4+CD25+ T Cells: Properties and Function
Room: Eric Harvie Theatre

Speaker 4 of 5
Brian R. Champion, PsiOxus Therapeutics Ltd, UK
Peripheral T-Cell Regulation through the Notch Signaling Pathway

Thursday, March 11 | 8:00AM - 11:00AM
CD4+CD25+ T Cells: Properties and Function
Room: Eric Harvie Theatre

Speaker 5 of 5
Dario A. A. Vignali, University of Pittsburgh School of Medicine, USA
Short Talk: Role of LAG-3 in Regulatory T Cell Function

Thursday, March 11 | 9:20AM - 9:40AM
Coffee Break
Room: Eric Harvie Foyer


Thursday, March 11 | 11:00AM - 1:00PM
Poster Setup
Room: Max Bell 251, 252, 253


Thursday, March 11 | 1:00PM - 10:00PM
Poster Viewing
Room: Max Bell 251, 252, 253


Thursday, March 11 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Eric Harvie Foyer


Thursday, March 11 | 5:00PM - 7:15PM
Induced Regulatory T Cells: Characterization and Function
Room: Eric Harvie Theatre

Speaker 1 of 4
* Maria Grazia Roncarolo, Stanford University School of Medicine, USA
Mechanisms Underlying the Induction and Effector Function of Tr1 Cells

Thursday, March 11 | 5:00PM - 7:15PM
Induced Regulatory T Cells: Characterization and Function
Room: Eric Harvie Theatre

Speaker 2 of 4
Luciano Adorini, Intercept Pharmaceuticals, Inc., Italy
The Role of Dendritic Cells in the Induction of Regulatory T Cells

Thursday, March 11 | 5:00PM - 7:15PM
Induced Regulatory T Cells: Characterization and Function
Room: Eric Harvie Theatre

Speaker 3 of 4
Catherine M. Hawrylowicz, King's College London, UK
Pharmacologic Induction of Regulatory T Cells


Thursday, March 11 | 5:00PM - 7:15PM
Induced Regulatory T Cells: Characterization and Function
Room: Eric Harvie Theatre

Speaker 4 of 4
Richard A. Flavell, HHMI/Yale University School of Medicine, USA
Regulation of the Autoimmune Response by Suppressor T Cells and Cytokines

Thursday, March 11 | 7:15PM - 8:15PM
Social Hour
Room: Max Bell Foyer


Thursday, March 11 | 7:30PM - 10:00PM
Poster Session 1
Room: Max Bell 251, 252, 253


Thursday, March 11 | 9:00PM - 10:00PM
Workshop 1
Room: Max Bell Auditorium

Speaker 1 of 7
* Ethan M. Shevach, NIAID, National Institutes of Health, USA

Thursday, March 11 | 9:00PM - 10:00PM
Workshop 1
Room: Max Bell Auditorium

Speaker 2 of 7
* Luciano Adorini, Intercept Pharmaceuticals, Inc., Italy

Thursday, March 11 | 9:00PM - 10:00PM
Workshop 1
Room: Max Bell Auditorium

Speaker 3 of 7
Xuguang Tai, National Cancer Institute, National Institutes of Health, USA
Molecular Mapping of CD28 Costimulatory Signals Required for Treg Cell Generation

Thursday, March 11 | 9:00PM - 10:00PM
Workshop 1
Room: Max Bell Auditorium

Speaker 4 of 7
Sylvain Fisson, University of Evry Val d'Essonne, France
Homeostasis and Function of Islet Antigen-Specific Regulatory T Cells

Thursday, March 11 | 9:00PM - 10:00PM
Workshop 1
Room: Max Bell Auditorium

Speaker 5 of 7
Mindi R. Walker, Johnson and Johnson, USA
Induction of FoxP3 and Acquisition of T Regulatory Activity by Stimulated Human CD4+CD25- T Cells

Thursday, March 11 | 9:00PM - 10:00PM
Workshop 1
Room: Max Bell Auditorium

Speaker 6 of 7
Shuang Liang, University of Louisville Health Sciences Center, USA
CD4+CD25- Cells can be Converted into CD4+CD25+ Regulatory T Cells in the Periphery in the Absence of the Thymus

Thursday, March 11 | 9:00PM - 10:00PM
Workshop 1
Room: Max Bell Auditorium

Speaker 7 of 7
Joerg Ermann, Stanford University, USA
IL-2 Receptor Signaling in CD4+CD25+ Treg Cells

Friday, March 12 | 7:00AM - 8:00AM
Breakfast
Room: Donald Cameron Hall


Friday, March 12 | 8:00AM - 11:00AM
Induction and Maintenance of Regulatory T Cells
Room: Eric Harvie Theatre

Speaker 1 of 4
Andrew Caton, Wistar Institute, USA
CD4+ CD25+ Regulatory T Cell Selection

Friday, March 12 | 8:00AM - 11:00AM
Induction and Maintenance of Regulatory T Cells
Room: Eric Harvie Theatre

Speaker 2 of 4
* Harald von Boehmer, Harvard Medical School, USA
In vivo Lifestyle of Regulatory T Cells

Friday, March 12 | 8:00AM - 11:00AM
Induction and Maintenance of Regulatory T Cells
Room: Eric Harvie Theatre

Speaker 3 of 4
Thomas R. Malek, University of Miami School of Medicine, USA
Role of IL-2 in the Production and Maintenance of T Regulatory Cells

Friday, March 12 | 8:00AM - 11:00AM
Induction and Maintenance of Regulatory T Cells
Room: Eric Harvie Theatre

Speaker 4 of 4
Marc A. Gavin, Amgen, USA
Short Talk: A Role for Phosphodiesterase 3B in the Homeostasis of CD4+CD25+ Regulatory T Cells

Friday, March 12 | 9:20AM - 9:40AM
Coffee Break
Room: Eric Harvie Foyer


Friday, March 12 | 11:00AM - 1:00PM
Poster Setup
Room: Max Bell 251, 252, 253


Friday, March 12 | 1:00PM - 10:00PM
Poster Viewing
Room: Max Bell 251, 252, 253


Friday, March 12 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Eric Harvie Foyer


Friday, March 12 | 5:00PM - 7:00PM
CD8+ Regulatory T Cells
Room: Eric Harvie Theatre

Speaker 1 of 5
* Luciano Adorini, Intercept Pharmaceuticals, Inc., Italy

Friday, March 12 | 5:00PM - 7:00PM
CD8+ Regulatory T Cells
Room: Eric Harvie Theatre

Speaker 2 of 5
Yong-Jun Liu, Sanofi, USA
Human GITR-Ligand Preferentially Costimulate Cytotoxic CD8+ T Cells

Friday, March 12 | 5:00PM - 7:00PM
CD8+ Regulatory T Cells
Room: Eric Harvie Theatre

Speaker 3 of 5
Nicole Suciu-Foca, Columbia University, USA
CD8+CD28- Suppressor T Cells


Friday, March 12 | 5:00PM - 7:00PM
CD8+ Regulatory T Cells
Room: Eric Harvie Theatre

Speaker 4 of 5
Vipin Kumar, Torrey Pines Institute for Molecular Studies, USA
A Novel, Non-Classical MHC-Restricted CD8+ Regulatory T Cell Population Prevents Experimental Autoimmune Encephalomyelitis

Friday, March 12 | 5:00PM - 7:00PM
CD8+ Regulatory T Cells
Room: Eric Harvie Theatre

Speaker 5 of 5
Eli E. Sercarz, Torrey Pines Institute for Molecular Studies, USA
Short Talk: The Optimal Targets for Regulatory T Cells Are Driver T Cell Clones

Friday, March 12 | 7:00PM - 8:00PM
Social Hour
Room: Max Bell Foyer


Friday, March 12 | 7:30PM - 10:00PM
Poster Session 2
Room: Max Bell 251, 252, 253


Friday, March 12 | 9:00PM - 10:00PM
Workshop 2
Room: Max Bell Auditorium

Speaker 1 of 7
* Ethan M. Shevach, NIAID, National Institutes of Health, USA

Friday, March 12 | 9:00PM - 10:00PM
Workshop 2
Room: Max Bell Auditorium

Speaker 2 of 7
* Luciano Adorini, Intercept Pharmaceuticals, Inc., Italy

Friday, March 12 | 9:00PM - 10:00PM
Workshop 2
Room: Max Bell Auditorium

Speaker 3 of 7
Vivian Tseveleki, Hellenic Pasteur Institute, Greece
Immunoregulatory Role of c-FLIPL in T Lymphocytes

Friday, March 12 | 9:00PM - 10:00PM
Workshop 2
Room: Max Bell Auditorium

Speaker 4 of 7
Niklas Beyersdorf, Institute for Virology and Immunobiology, Germany
Expansion and Activation of Rat CD4+CD25+ Regulatory T Cells by Superagonistic CD28-Specific Monoclonal Antibodies

Friday, March 12 | 9:00PM - 10:00PM
Workshop 2
Room: Max Bell Auditorium

Speaker 5 of 7
Kerstin Siegmund, Charité, Humboldt-Universitaet, Germany
Developmental Stage, Phenotype and Migration Distinguish Naïve- and Effector/Memory-Like CD4+ Regulatory T Cells

Friday, March 12 | 9:00PM - 10:00PM
Workshop 2
Room: Max Bell Auditorium

Speaker 6 of 7
Alistair Noble, Rayne Institute, UK
CD8+, MHC Class I-Restricted Suppressor T Cells Secrete IFN-gamma and IL-10 but Act via Cell Contact Dependent Mechanisms

Friday, March 12 | 9:00PM - 10:00PM
Workshop 2
Room: Max Bell Auditorium

Speaker 7 of 7
Chyi-Song Hsieh, Washington University, USA
Recognition of the Peripheral Self by Naturally-Arising CD25+ CD4+ T Cell Receptors

Saturday, March 13 | 7:00AM - 8:00AM
Breakfast
Room: Donald Cameron Hall


Saturday, March 13 | 8:00AM - 11:00AM
Regulation of Immunity to Tumors and Infectious Agents
Room: Eric Harvie Theatre

Speaker 1 of 5
Cornelis J. M. Melief, Leiden University Medical Center & ISA Pharmaceuticals BV, Netherlands
Induction of Effective Tumor Immunity

Saturday, March 13 | 8:00AM - 11:00AM
Regulation of Immunity to Tumors and Infectious Agents
Room: Eric Harvie Theatre

Speaker 2 of 5
Kingston H.G. Mills, Trinity College Dublin, Ireland
T Cell Mediated Regulation of Immunity to Bacteria

Saturday, March 13 | 8:00AM - 11:00AM
Regulation of Immunity to Tumors and Infectious Agents
Room: Eric Harvie Theatre

Speaker 3 of 5
Yasmine Belkaid, NIAID, National Institutes of Health, USA
Regulatory T Cells Maintain Symbiosis between Immunity and Susceptibility to Parasite Infection

Saturday, March 13 | 8:00AM - 11:00AM
Regulation of Immunity to Tumors and Infectious Agents
Room: Eric Harvie Theatre

Speaker 4 of 5
* Matthias G. von Herrath, Novo Nordisk and La Jolla Institute for Allergy and Immunology, USA
CD25+ Regulatory Cells in Viral Infections?

Saturday, March 13 | 8:00AM - 11:00AM
Regulation of Immunity to Tumors and Infectious Agents
Room: Eric Harvie Theatre

Speaker 5 of 5
Weiping Zou, University of Michigan, USA
Short Talk: Specific Recruitment of Regulatory T Cells Fosters Immune Privilege in Ovarian Carcinoma

Saturday, March 13 | 9:20AM - 9:40AM
Coffee Break
Room: Eric Harvie Foyer


Saturday, March 13 | 11:00AM - 1:00PM
Poster Setup
Room: Max Bell 251, 252, 253


Saturday, March 13 | 1:00PM - 10:00PM
Poster Viewing
Room: Max Bell 251, 252, 253


Saturday, March 13 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Eric Harvie Foyer


Saturday, March 13 | 5:00PM - 7:00PM
Regulatory T Cells in Human Disease Session Sponsored in par
t by the National Multiple Sclerosis Society

Room: Eric Harvie Theatre

Speaker 1 of 4
Alexander H. Enk, Universitäts-Hautklinik Heidelberg, Germany
In vivo Function and Manipulation of Regulatory T Cells

Saturday, March 13 | 5:00PM - 7:00PM
Regulatory T Cells in Human Disease Session Sponsored in par
t by the National Multiple Sclerosis Society

Room: Eric Harvie Theatre

Speaker 2 of 4
* David A. Hafler, Yale University School of Medicine, USA
CD4+CD25+ Regulatory T Cells are Altered in Patients with Multiple Sclerosis

Saturday, March 13 | 5:00PM - 7:00PM
Regulatory T Cells in Human Disease Session Sponsored in par
t by the National Multiple Sclerosis Society

Room: Eric Harvie Theatre

Speaker 3 of 4
Arne N. Akbar, University College London, UK
Are Human CD4+CD25+ T Cells Derived From Effector Cells?

Saturday, March 13 | 5:00PM - 7:00PM
Regulatory T Cells in Human Disease Session Sponsored in par
t by the National Multiple Sclerosis Society

Room: Eric Harvie Theatre

Speaker 4 of 4
Francesco Annunziato, University of Florence, Italy
Short Talk: Effect of CD4+CD25+ or CD8+CD25+ FOXP3-Expressing Human T Regulatory Thymocytes on the Function of Autologous TH1 and TH2 Cells

Saturday, March 13 | 7:00PM - 8:00PM
Social Hour
Room: Max Bell Foyer


Saturday, March 13 | 7:30PM - 10:00PM
Poster Session 3
Room: Max Bell 251, 252, 253


Saturday, March 13 | 9:00PM - 10:00PM
Workshop 3
Room: Max Bell Auditorium

Speaker 1 of 7
* Ethan M. Shevach, NIAID, National Institutes of Health, USA

Saturday, March 13 | 9:00PM - 10:00PM
Workshop 3
Room: Max Bell Auditorium

Speaker 2 of 7
* Luciano Adorini, Intercept Pharmaceuticals, Inc., Italy

Saturday, March 13 | 9:00PM - 10:00PM
Workshop 3
Room: Max Bell Auditorium

Speaker 3 of 7
Salvatore Albani, University of California, San Diego, USA
Epitope-Specific Immunotherapy Induces Immune Deviation of Pro-Inflammatory T Cells in Rheumatoid Arthritis

Saturday, March 13 | 9:00PM - 10:00PM
Workshop 3
Room: Max Bell Auditorium

Speaker 4 of 7
Claudia Mauri, University College London, UK
The Generation and Function of Regulatory T Cells are Defective in Rheumatoid Arthritis: Reversal by Anti-TNFalpha Therapy

Saturday, March 13 | 9:00PM - 10:00PM
Workshop 3
Room: Max Bell Auditorium

Speaker 5 of 7
Rong-Fu Wang, Baylor College of Medicine, USA
Identification of Natural Ligands for Human CD4+ Regulatory T Cells: Implication for Immunotherapy

Saturday, March 13 | 9:00PM - 10:00PM
Workshop 3
Room: Max Bell Auditorium

Speaker 6 of 7
Susmit Suvas, Oakland University, USA
Role of CD4+CD25+ Regulatory T Cells in Herpes Viral Infection

Saturday, March 13 | 9:00PM - 10:00PM
Workshop 3
Room: Max Bell Auditorium

Speaker 7 of 7
Robert N. Barker, University of Aberdeen, UK
Immunosuppressive Regulatory T Cells in Hodgkin Lymphoma and Epstein-Barr Virus Infection

Sunday, March 14 | 7:00AM - 8:00AM
Breakfast
Room: Donald Cameron Hall


Sunday, March 14 | 8:00AM - 11:00AM
Regulatory T Cell in Autoimmunity Session Sponsored in part
by the Juvenile Diabetes Research Foundation International

Room: Eric Harvie Theatre

Speaker 1 of 5
Kenneth S. Tung, University of Virginia, USA
Regional Lymph Node Regulation in 3dTx Mice

Sunday, March 14 | 8:00AM - 11:00AM
Regulatory T Cell in Autoimmunity Session Sponsored in part
by the Juvenile Diabetes Research Foundation International

Room: Eric Harvie Theatre

Speaker 2 of 5
Fiona M. Powrie, University of Oxford, UK
Control of Immune Pathology by Regulatory T Cells

Sunday, March 14 | 8:00AM - 11:00AM
Regulatory T Cell in Autoimmunity Session Sponsored in part
by the Juvenile Diabetes Research Foundation International

Room: Eric Harvie Theatre

Speaker 3 of 5
* Joan Goverman, University of Washington, USA
Suppression of Myelin-Specific T Cells In Vivo

Sunday, March 14 | 8:00AM - 11:00AM
Regulatory T Cell in Autoimmunity Session Sponsored in part
by the Juvenile Diabetes Research Foundation International

Room: Eric Harvie Theatre

Speaker 4 of 5
Jeffrey A. Bluestone, University of California, San Francisco, USA
Antigen-Specificity and Function of Regulatory T Cells

Sunday, March 14 | 8:00AM - 11:00AM
Regulatory T Cell in Autoimmunity Session Sponsored in part
by the Juvenile Diabetes Research Foundation International

Room: Eric Harvie Theatre

Speaker 5 of 5
Kristin V. Tarbell, Amgen, USA
Short Talk: CD25+ CD4+ T Cells, Expanded with Dendritic Cells Presenting a Single Autoantigenic Peptide, Block the Development of Diabetes in NOD Mice

Sunday, March 14 | 9:20AM - 9:40AM
Coffee Break
Room: Eric Harvie Foyer


Sunday, March 14 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Eric Harvie Foyer


Sunday, March 14 | 5:00PM - 7:00PM
Regulatory T Cells in Transplantation and GVHD
Room: Eric Harvie Theatre

Speaker 1 of 4
Kathryn J. Wood, University of Oxford, UK
Manipulation of Regulatory T Cell Function in Transplantation


Sunday, March 14 | 5:00PM - 7:00PM
Regulatory T Cells in Transplantation and GVHD
Room: Eric Harvie Theatre

Speaker 2 of 4
Bruce R. Blazar, University of Minnesota, USA
The Role of CD4+CD25+ T Regulatory (Treg) Cells in Allogeneic Bone Marrow Transplantation (BMT)

Sunday, March 14 | 5:00PM - 7:00PM
Regulatory T Cells in Transplantation and GVHD
Room: Eric Harvie Theatre

Speaker 3 of 4
* Herman Waldmann, University of Oxford, UK
Regulatory T Cells in Infectious Transplantion Tolerance

Sunday, March 14 | 5:00PM - 7:00PM
Regulatory T Cells in Transplantation and GVHD
Room: Eric Harvie Theatre

Speaker 4 of 4
Sergio A. Quezada, University College London, UK
Short Talk: Visualizing Regulatory T Cell Control of Anti CD154-Induced Graft Tolerance in vivo

Sunday, March 14 | 7:30PM - 8:30PM
Social Hour
Room: Donald Cameron Hall


Sunday, March 14 | 8:00PM - 11:00PM
Cash Bar
Room: Donald Cameron Hall


Sunday, March 14 | 8:30PM - 11:30PM
Entertainment
Room: Donald Cameron Hall


Monday, March 15 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.