Web Desc
Biology of Hypoxia: The Role of Oxygen Sensing in Development, Normal Function and Disease
Organizer(s): Randall S. Johnson, Amato Giaccia and M. Celeste Simon
Date: March 25 - 30, 2004
Location: Sheraton Steamboat Resort, Steamboat Springs, CO, USA
Sponsored in part by the Director's Sponsor Fund
Summary of Meeting:
Upon completion of this conference, participants should be able to: - Understand the most current and important aspects of hypoxia research generally - Appreciate current understanding of relationships between hypoxia and angiogenesis - Understand the relationship between oxygen sensing and metabolic function, particularly as it relates to cell and tissue survival during hypoxic injury - Appreciate current thinking on the role of oxygen sensing and hypoxic response in ischemic injuries, such as stroke and myocardial infarction - Gain an understanding of current ideas about the molecular sensing and signaling mechanisms induced by hypoxia - Understand the developmental roles oxygen sensing fulfill in model organisms, and gain insights into how these are relevant to human biology/pathology. A chief objective will be to bring the very disparate groups that work on hypoxia together. There is currently no other meeting where this occurs, and it will allow, we believe, unprecedented opportunities for cross-fertilization and collaboration to occur. A number of controversies on the mechanisms and effects of oxygen exist in the current literature; this meeting will bring the various points of view into the same setting and will allow a consensus on these issues to be built.
Discounted Abstract Deadline: November 24 2003
Discounted Registration Deadline: January 26 2004
We gratefully acknowledge the generous grant for this conference provided by:

National Institute on Aging (NIA)
Grant No. 1R13AG023493-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Thursday, March 25 | 3:00PM - 7:00PM
Registration
Room: Foyer


Thursday, March 25 | 6:15PM - 7:15PM
Refreshments
Room: Foyer


Thursday, March 25 | 7:15PM - 7:30PM
Orientation
Room: Storm Peak/Mt. Werner


Thursday, March 25 | 7:30PM - 9:00PM
Presentations on Hypoxia: Current State of the Field and Fut
ure Directions
Room: Storm Peak/Mt. Werner

Speaker 3 of 3
Amato J. Giaccia, Stanford University, USA
Molecular Therapeutics Based on the Proteomic/Genomic Response in Hypoxia

Thursday, March 25 | 7:30PM - 9:00PM
Presentations on Hypoxia: Current State of the Field and Fut
ure Directions
Room: Storm Peak/Mt. Werner

Speaker 2 of 3
Randall S. Johnson, University of Cambridge, UK
The Physiology of Hypoxia: The Role of Molecular Adaptation

Thursday, March 25 | 7:30PM - 9:00PM
Presentations on Hypoxia: Current State of the Field and Fut
ure Directions
Room: Storm Peak/Mt. Werner

Speaker 1 of 3
M. Celeste Simon, University of Pennsylvania, USA
Oxygen Sensing in Development and Disease

Friday, March 26 | 7:00AM - 8:00AM
Breakfast
Room: 3 Saddles/Sevens


Friday, March 26 | 8:00AM - 11:00AM
Function of Hypoxic Response in Development I: Model Organis
ms and Mammals

Room: Storm Peak/Mt. Werner

Speaker 4 of 4
Peter F. Carmeliet, University of Leuven, VIB, Belgium
Functional Analysis of the Role of the Oxygen Sensors PHD1, PHD2 and PHD3 Using Gene-Inactivation in Mice And Morpholino-Knockdown in Zebrafish

Friday, March 26 | 8:00AM - 11:00AM
Function of Hypoxic Response in Development I: Model Organis
ms and Mammals

Room: Storm Peak/Mt. Werner

Speaker 3 of 4
* Gregg L. Semenza, Johns Hopkins University School of Medicine, USA
Regulation of Oxygen Homeostasis by Hypoxia-Inducible Factor 1

Friday, March 26 | 8:00AM - 11:00AM
Function of Hypoxic Response in Development I: Model Organis
ms and Mammals

Room: Storm Peak/Mt. Werner

Speaker 2 of 4
Christopher Bradfield, University of Wisconsin, USA
Understanding Hypoxia Signalling from a Superfamily Perspective

Friday, March 26 | 8:00AM - 11:00AM
Function of Hypoxic Response in Development I: Model Organis
ms and Mammals

Room: Storm Peak/Mt. Werner

Speaker 1 of 4
Robert O. Poyton, University of Colorado, Boulder, USA
Mitochondrial-Nuclear Interaction in O2 Sensing

Friday, March 26 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Friday, March 26 | 11:00AM - 1:00PM
Poster Setup
Room: Sunshine Peak


Friday, March 26 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunshine Peak


Friday, March 26 | 4:30PM - 4:45PM
Coffee & Snacks Available
Room: Foyer


Friday, March 26 | 4:45PM - 7:15PM
Function of Hypoxic Response in Development II: Mammalian Sy
stems

Room: Storm Peak/Mt. Werner

Speaker 5 of 5
David C. Beebe, Washington University, USA
Short Talk: Oxygen Regulates Lens Cell Proliferation and Governs Lens Growth in Adult Rats

Friday, March 26 | 4:45PM - 7:15PM
Function of Hypoxic Response in Development II: Mammalian Sy
stems

Room: Storm Peak/Mt. Werner

Speaker 4 of 5
Ernestina Schipani, University of Michigan, USA
Chondrogenesis and Hypoxia

Friday, March 26 | 4:45PM - 7:15PM
Function of Hypoxic Response in Development II: Mammalian Sy
stems

Room: Storm Peak/Mt. Werner

Speaker 3 of 5
Roland H. Wenger, University of Zürich, Switzerland
HIF-1, PASKIN and the Hypoxic Response in Male Germ Cell Differentiation

Friday, March 26 | 4:45PM - 7:15PM
Function of Hypoxic Response in Development II: Mammalian Sy
stems

Room: Storm Peak/Mt. Werner

Speaker 2 of 5
Jeffrey M. Arbeit, Washington University School of Medicine, USA
Persistent Neonatal Quiescent Hypervascularity Produced by Chronic Constitutive HIF-1alpha Signaling in Transgenic Mice

Friday, March 26 | 4:45PM - 7:15PM
Function of Hypoxic Response in Development II: Mammalian Sy
stems

Room: Storm Peak/Mt. Werner

Speaker 1 of 5
* Max Gassmann, University of Zürich, Switzerland
Hypoxia-Independent Erythropoietin Gene Expression

Friday, March 26 | 7:15PM - 8:15PM
Social Hour
Room: Foyer


Friday, March 26 | 7:30PM - 10:00PM
Poster Session 1
Room: Sunshine Peak


Saturday, March 27 | 7:00AM - 8:00AM
Breakfast
Room: 3 Saddles/Sevens


Saturday, March 27 | 8:00AM - 11:00AM
Pulmonary Hypoxia
Room: Storm Peak/Mt. Werner

Speaker 1 of 4
Stella Kourembanas, Children's Hospital Boston, Harvard Medical School, USA
Molecular and Cellular Responses of the Lung to Hypoxia

Saturday, March 27 | 8:00AM - 11:00AM
Pulmonary Hypoxia
Room: Storm Peak/Mt. Werner

Speaker 2 of 4
Larrisa A. Shimoda, Johns Hopkins School of Medicine, USA
Hypoxia-Induced Alterations in Smooth Muscle Cell Ion Homeostasis

Saturday, March 27 | 8:00AM - 11:00AM
Pulmonary Hypoxia
Room: Storm Peak/Mt. Werner

Speaker 3 of 4
Ivan F. McMurtry, University of Colorado Health Sciences Center, USA
Role of RhoA/Rho Kinase Signaling in Hypoxic Pulmonary Hypertension

Saturday, March 27 | 8:00AM - 11:00AM
Pulmonary Hypoxia
Room: Storm Peak/Mt. Werner

Speaker 4 of 4
* Stephen L. Archer, Queen's University, Canada
O2 Sensors in the Ductus Arteriosis and the Pulmonary Artery

Saturday, March 27 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Saturday, March 27 | 11:00AM - 1:00PM
Poster Setup
Room: Sunshine Peak


Saturday, March 27 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunshine Peak


Saturday, March 27 | 2:00PM - 4:00PM
Workshop: HIF-1 and Drug Development
Room: Storm Peak/Mt. Werner

Speaker 1 of 7
* M. Celeste Simon, University of Pennsylvania, USA

Saturday, March 27 | 2:00PM - 4:00PM
Workshop: HIF-1 and Drug Development
Room: Storm Peak/Mt. Werner

Speaker 2 of 7
Alexey V. Bazarov, University of California, San Francisco, USA
Reaching for Fresh Air: Implication of HIF-1a in Astrocytoma Invasion

Saturday, March 27 | 2:00PM - 4:00PM
Workshop: HIF-1 and Drug Development
Room: Storm Peak/Mt. Werner

Speaker 3 of 7
Navdeep S. Chandel, Northwestern University, USA
Mitochondrial Electron Transport Chain Regulates HIF-1alpha Protein Stabilization Independent of Respiration

Saturday, March 27 | 2:00PM - 4:00PM
Workshop: HIF-1 and Drug Development
Room: Storm Peak/Mt. Werner

Speaker 4 of 7
Cormac Taylor, University College Dublin, Ireland
Redistribution of Intracellular Oxygen in Hypoxia by Nitric Oxide: Effect on HIF1alpha

Saturday, March 27 | 2:00PM - 4:00PM
Workshop: HIF-1 and Drug Development
Room: Storm Peak/Mt. Werner

Speaker 5 of 7
L. Eric Huang, University of Utah, USA
A Paradoxial Role for Hypoxia in Cell Growth

Saturday, March 27 | 2:00PM - 4:00PM
Workshop: HIF-1 and Drug Development
Room: Storm Peak/Mt. Werner

Speaker 6 of 7
Till Acker, University of Giessen, Germany
Regulation of HIF and HPHD Function in Malignant Brain Tumors

Saturday, March 27 | 2:00PM - 4:00PM
Workshop: HIF-1 and Drug Development
Room: Storm Peak/Mt. Werner

Speaker 7 of 7
Koh Nakayama, Sanford-Burnham Medical Research Institute, USA
Regulation of PHD Abundance by SIAH2 E3 Ligase Modulates the Expresession of HIF1alpha Level in Hypoxia

Saturday, March 27 | 4:30PM - 4:45PM
Coffee & Snacks Available
Room: Foyer


Saturday, March 27 | 4:45PM - 7:00PM
Carotid Body Sensing of Oxygen: Hypoxic Sensing and Physiolo
gy

Room: Storm Peak/Mt. Werner

Speaker 1 of 5
Nanduri R. Prabhakar, University of Chicago, USA
Plasticity in Hypoxic Sensing at the Carotid Body

Saturday, March 27 | 4:45PM - 7:00PM
Carotid Body Sensing of Oxygen: Hypoxic Sensing and Physiolo
gy

Room: Storm Peak/Mt. Werner

Speaker 2 of 5
José López-Barneó, University of Seville, Spain
Regulation of O2 Sensing by Ion Channels

Saturday, March 27 | 4:45PM - 7:00PM
Carotid Body Sensing of Oxygen: Hypoxic Sensing and Physiolo
gy

Room: Storm Peak/Mt. Werner

Speaker 3 of 5
Frank J. Giordano, Yale University, USA
HIF-1alpha in the Heart: The Good, the Bad, the Ugly

Saturday, March 27 | 4:45PM - 7:00PM
Carotid Body Sensing of Oxygen: Hypoxic Sensing and Physiolo
gy

Room: Storm Peak/Mt. Werner

Speaker 4 of 5
* Kenneth Walsh, University of Virginia School of Medicine, USA
Growth Signals in the Heart and Vasculature

Saturday, March 27 | 4:45PM - 7:00PM
Carotid Body Sensing of Oxygen: Hypoxic Sensing and Physiolo
gy

Room: Storm Peak/Mt. Werner

Speaker 5 of 5
John W. Severinghaus, University of California, San Francisco, USA
Consensus Proposal for Hypoxic Ventilatory Response

Saturday, March 27 | 7:00PM - 8:00PM
Social Hour
Room: Foyer


Saturday, March 27 | 7:30PM - 10:00PM
Poster Session 2
Room: Sunshine Peak


Sunday, March 28 | 7:00AM - 8:00AM
Breakfast
Room: 3 Saddles/Sevens


Sunday, March 28 | 8:00AM - 11:00AM
Hypoxia-Induced Cell Death and Drug Discovery
Room: Storm Peak/Mt. Werner

Speaker 1 of 4
Dietmar W. Siemann, University of Florida, USA
Vascular Targeting: Induction of Ischemic Cell Death in Cancer Therapy

Sunday, March 28 | 8:00AM - 11:00AM
Hypoxia-Induced Cell Death and Drug Discovery
Room: Storm Peak/Mt. Werner

Speaker 2 of 4
Martin Brown, Stanford University, USA
Exploiting Tumor Hypoxia in Cancer Therapy

Sunday, March 28 | 8:00AM - 11:00AM
Hypoxia-Induced Cell Death and Drug Discovery
Room: Storm Peak/Mt. Werner

Speaker 3 of 4
Giovanni Melillo, Immuno-Oncology at AstraZeneca, USA
Targeting HIF-1 for Development of Cancer Therapeutics

Sunday, March 28 | 8:00AM - 11:00AM
Hypoxia-Induced Cell Death and Drug Discovery
Room: Storm Peak/Mt. Werner

Speaker 4 of 4
Mark W. Dewhirst, Duke University Medical Center, USA
Paradoxical HIF-1alpha Signaling during Tumor Reoxygenation: The Role of Free Radicals and Stress Granules

Sunday, March 28 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Sunday, March 28 | 11:00AM - 1:00PM
Poster Setup
Room: Sunshine Peak


Sunday, March 28 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunshine Peak


Sunday, March 28 | 4:30PM - 4:45PM
Coffee & Snacks Available
Room: Foyer


Sunday, March 28 | 4:45PM - 7:00PM
Hypoxia and Tumorigenesis
Room: Storm Peak/Mt. Werner

Speaker 1 of 5
* Adrian L. Harris, University of Oxford, Weatherall Institute of Molecular Medicine, UK
Hypoxia and Tumorigenesis

Sunday, March 28 | 4:45PM - 7:00PM
Hypoxia and Tumorigenesis
Room: Storm Peak/Mt. Werner

Speaker 2 of 5
William G. Kaelin, Jr., Dana-Farber Cancer Institute, USA
Molecular Pathogenesis of the von Hippel-Lindau Hereditary Cancer Syndrome

Sunday, March 28 | 4:45PM - 7:00PM
Hypoxia and Tumorigenesis
Room: Storm Peak/Mt. Werner

Speaker 3 of 5
Volker H. Haase, Vanderbilt University, USA
Functional Consequences of Conditional Inactivation of Vhl: The Role of Hif

Sunday, March 28 | 4:45PM - 7:00PM
Hypoxia and Tumorigenesis
Room: Storm Peak/Mt. Werner

Speaker 4 of 5
Peter Vaupel, University of Mainz, Germany
Tumors: Out of Oxygen, but Still Alive and Kicking

Sunday, March 28 | 4:45PM - 7:00PM
Hypoxia and Tumorigenesis
Room: Storm Peak/Mt. Werner


Short Talk(s) Chosen from Abstracts

Sunday, March 28 | 7:00PM - 8:00PM
Social Hour
Room: Foyer


Sunday, March 28 | 7:30PM - 10:00PM
Poster Session 3
Room: Sunshine Peak


Monday, March 29 | 7:00AM - 8:00AM
Breakfast
Room: 3 Saddles/Sevens


Monday, March 29 | 8:00AM - 11:00AM
Signaling of Hypoxia
Room: Storm Peak/Mt. Werner

Speaker 1 of 5
Jacques Pouysségur, University of Nice, France
Interplay between Oxygen-Sensors in HIF-1 Signaling

Monday, March 29 | 8:00AM - 11:00AM
Signaling of Hypoxia
Room: Storm Peak/Mt. Werner

Speaker 2 of 5
Paul T. Schumacker, Northwestern University, USA
Reactive Oxygen Species and Signaling of Hypoxia

Monday, March 29 | 8:00AM - 11:00AM
Signaling of Hypoxia
Room: Storm Peak/Mt. Werner

Speaker 3 of 5
* Peter J. Ratcliffe, University of Oxford, UK
The Role of VHL and Protein Hydroxylation in Hypoxia Signaling

Monday, March 29 | 8:00AM - 11:00AM
Signaling of Hypoxia
Room: Storm Peak/Mt. Werner

Speaker 4 of 5
Frank S. Lee, University of Pennsylvania School of Medicine, USA
Short Talk: A P582S Polymorphism of Hypoxia Inducible Factor-1alpha (HIF-1a) Does Not Impair Pro-564 Hydroxylation

Monday, March 29 | 8:00AM - 11:00AM
Signaling of Hypoxia
Room: Storm Peak/Mt. Werner

Speaker 5 of 5
Wayne S. Zundel, University of Colorado Health Sciences Center, USA
Short Talk: Distinct Aerobic and Hypoxic Mechanisms of HIF-1 Regulation by CSN5

Monday, March 29 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Monday, March 29 | 4:30PM - 4:45PM
Coffee & Snacks Available
Room: Foyer


Monday, March 29 | 4:45PM - 7:15PM
Signaling of Hypoxia II
Room: Storm Peak/Mt. Werner

Speaker 1 of 5
Lorenz Poellinger, Karolinska Institutet, Sweden
Structure of HIF-1 and Relationship to Hypoxia Signaling


Monday, March 29 | 4:45PM - 7:15PM
Signaling of Hypoxia II
Room: Storm Peak/Mt. Werner

Speaker 2 of 5
* H. Franklin Bunn, Brigham and Women's Hospital, USA
HIF Activation and Oxygen-Dependent Gene Expression in Invertebrates

Monday, March 29 | 4:45PM - 7:15PM
Signaling of Hypoxia II
Room: Storm Peak/Mt. Werner

Speaker 3 of 5
Daniel J. Peet, University of Adelaide, Australia
Normoxic Activation of HIF2 alpha by NEMO

Monday, March 29 | 4:45PM - 7:15PM
Signaling of Hypoxia II
Room: Storm Peak/Mt. Werner

Speaker 4 of 5
Joseph A. Garcia, Columbia University Medical Center, USA
Insights from EPAS1/HIF-2a Null Mice: The Role of HIF-2 in ROS & Mitochondrial Homeostasis

Monday, March 29 | 4:45PM - 7:15PM
Signaling of Hypoxia II
Room: Storm Peak/Mt. Werner

Speaker 5 of 5
Mark A. Krasnow, Stanford University School of Medicine, USA
Genetic Dissection of Hypoxia Response Pathways in Drosophila

Monday, March 29 | 8:00PM - 9:00PM
Social Hour
Room: Foyer


Monday, March 29 | 8:00PM - 11:00PM
Entertainment
Room: Sunshine Peak/Mt. Werner


Monday, March 29 | 8:00PM - 11:00PM
Cash Bar
Room: Sunshine Peak/Mt. Werner


Tuesday, March 30 | 10:26AM - 10:26AM
Departure


*Session Chair.