Web Desc
Molecular Cell Biology of Lipid Domains
Organizer(s): Richard G.W. Anderson, Michael S. Brown and Joseph L. Goldstein
Date: March 26 - 31, 2004
Location: Fairmont Hotel Vancouver, Vancouver, BC, Canada
Supported by Keystone Symposia
Summary of Meeting:
Lipid domains are a class of membrane domains that compartmentalize signaling modules, regulate the transport of ions, molecules and macromolecular complexes to specific cellular sites, and spatially organize signal transduction in polarized cells. The purpose of this meeting is to bring together a diverse set of investigators with the goal of exploring the molecular basis of lipid domain function. The topics to be discussed include: intracellular traffic of lipid domains; role of lipid domains in bacterial and viral pathogenesis; signal transduction from lipid domains; mechanisms of protein/lipid sorting by lipid domains; lipid traffic through lipid domains: structural basis of protein function in lipid domains; biogenesis of lipid domains; biophysics of lipid lateral organization.
Discounted Abstract Deadline: November 24 2003
Discounted Registration Deadline: January 27 2004
We gratefully acknowledge additional support for this conference from:

Avanti Polar Lipids, Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Friday, March 26 | 3:00PM - 7:00PM
Registration
Room: Vancouver Island Alcove


Friday, March 26 | 6:15PM - 7:15PM
Refreshments
Room: British Ballroom


Friday, March 26 | 7:15PM - 7:30PM
Orientation
Room: Columbia Ballroom


Friday, March 26 | 7:30PM - 7:45PM
Opening Remarks

Speaker 3 of 3
Joseph L. Goldstein, University of Texas Southwestern Medical Center, USA

Friday, March 26 | 7:30PM - 7:45PM
Opening Remarks

Speaker 2 of 3
Michael S. Brown, University of Texas Southwestern Medical Center, USA

Friday, March 26 | 7:30PM - 7:45PM
Opening Remarks

Speaker 1 of 3
Richard G.W. Anderson, University of Texas Southwestern Medical Center, USA

Friday, March 26 | 7:45PM - 8:45PM
Keynote Address
Room: Columbia Ballroom

Speaker 1 of 1
Kai Simons, Max Planck Institute of Molecular Cell Biology and Genetics, Germany
Lipid Rafts: Structure and Function

Saturday, March 27 | 7:00AM - 8:00AM
Breakfast
Room: British Ballroom


Saturday, March 27 | 8:00AM - 11:00AM
Biophysics of Lipid Lateral Organization
Room: Columbia Ballroom

Speaker 5 of 5
Nicole S. Sampson, Stony Brook University, USA
Short Talk: Cholesterol Oxidase Senses Subtle Changes in Lipid Bilayer Structure

Saturday, March 27 | 8:00AM - 11:00AM
Biophysics of Lipid Lateral Organization
Room: Columbia Ballroom

Speaker 4 of 5
Ken Jacobson, University of North Carolina at Chapel Hill, USA
Detecting Lipid Domains in Living Cells

Saturday, March 27 | 8:00AM - 11:00AM
Biophysics of Lipid Lateral Organization
Room: Columbia Ballroom

Speaker 3 of 5
Akihiro Kusumi, Kyoto University, Japan
Calcium Signaling Induced by Transient Recruitment of PLCgamma to the Raft Stabilized by Clustering of GPI-Anchored Receptors: Single Molecule Observations

Saturday, March 27 | 8:00AM - 11:00AM
Biophysics of Lipid Lateral Organization
Room: Columbia Ballroom

Speaker 2 of 5
* Anne K. Kenworthy, USA
Dynamics of Lipid Rafts at the Cell Surface

Saturday, March 27 | 8:00AM - 11:00AM
Biophysics of Lipid Lateral Organization
Room: Columbia Ballroom

Speaker 1 of 5
Harden M. McConnell, Stanford University, USA
Condensed Complexes of Cholesterol and Phospholipids

Saturday, March 27 | 9:20AM - 9:40AM
Coffee Break
Room: British Columbia Foyer


Saturday, March 27 | 11:00AM - 1:00PM
Poster Setup
Room: British Ballroom


Saturday, March 27 | 1:00PM - 10:00PM
Poster Viewing
Room: British Ballroom


Saturday, March 27 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: British Columbia Foyer


Saturday, March 27 | 5:00PM - 7:00PM
Biogenesis and Maintenance of Lipid Domains: Intracellular L
ipid Transport

Room: Columbia Ballroom

Speaker 4 of 4
Raquel F. Epand, McMaster University, Canada
Short Talk: Cholesterol-Dependent Partitioning of PIP2 into Membrane Domains by the Amino Terminal Fragment of NAP-22

Saturday, March 27 | 5:00PM - 7:00PM
Biogenesis and Maintenance of Lipid Domains: Intracellular L
ipid Transport

Room: Columbia Ballroom

Speaker 3 of 4
* Richard G.W. Anderson, University of Texas Southwestern Medical Center, USA
Caveolae, Signal Transduction and Lipid Metabolism: What are the Connections?

Saturday, March 27 | 5:00PM - 7:00PM
Biogenesis and Maintenance of Lipid Domains: Intracellular L
ipid Transport

Room: Columbia Ballroom

Speaker 2 of 4
Geoffrey Chang, The Scripps Research Institute, USA
Structures of Multidrug Resistance ABC Transporter Homologs

Saturday, March 27 | 5:00PM - 7:00PM
Biogenesis and Maintenance of Lipid Domains: Intracellular L
ipid Transport

Room: Columbia Ballroom

Speaker 1 of 4
Dennis R. Voelker, National Jewish Health, USA
Protein and Lipid Motifs Regulating Lipid Traffic in Membrane Biogenesis

Saturday, March 27 | 7:00PM - 8:00PM
Social Hour
Room: British Ballroom


Saturday, March 27 | 7:30PM - 10:00PM
Poster Session 1: Biophysics of Lipid Lateral Organization/B
iogenesis and Maintenance of Lipid Domains: Intracellular Lipid Transport and Protein Function in the Bilayer
Room: British Ballroom


Sunday, March 28 | 7:00AM - 8:00AM
Breakfast
Room: British Ballroom


Sunday, March 28 | 8:00AM - 11:00AM
Biogenesis and Maintenance of Lipid Domains: Protein Functio
n in the Bilayer

Room: Columbia Ballroom

Speaker 1 of 5
Hartmut Michel, Max Planck Institute for Biophysics, Germany
Structure of Membrane Proteins: Interaction with Lipids as Found by Crystallography

Sunday, March 28 | 8:00AM - 11:00AM
Biogenesis and Maintenance of Lipid Domains: Protein Functio
n in the Bilayer

Room: Columbia Ballroom

Speaker 2 of 5
James H. Hurley, University of California, Berkeley, USA
Structural Mechanisms in Lipid Signaling and Metabolism

Sunday, March 28 | 8:00AM - 11:00AM
Biogenesis and Maintenance of Lipid Domains: Protein Functio
n in the Bilayer

Room: Columbia Ballroom

Speaker 3 of 5
* Arthur E. Johnson, Texas A & M University System Health Science Center, USA
Cholesterol-Dependent Binding, Oligomerization, and Pore Formation by a Bacterial Protein Toxin

Sunday, March 28 | 8:00AM - 11:00AM
Biogenesis and Maintenance of Lipid Domains: Protein Functio
n in the Bilayer

Room: Columbia Ballroom

Speaker 4 of 5
F. Gisou van der Goot, Federal Polytechnic School of Lausanne, Switzerland
Role of Lipid Domains in the Mode of Action of Bacterial Toxins

Sunday, March 28 | 8:00AM - 11:00AM
Biogenesis and Maintenance of Lipid Domains: Protein Functio
n in the Bilayer

Room: Columbia Ballroom

Speaker 5 of 5
Vassilis I. Zannis, Boston University School of Medicine, USA
Short Talk: Physical and Functional Interactions between apoA-I and ABCA1 Variants Explain the Structural Requirements for Lipid Efflux and Biogenesis of HDL

Sunday, March 28 | 9:20AM - 9:40AM
Coffee Break
Room: British Columbia Foyer


Sunday, March 28 | 11:00AM - 1:00PM
Poster Setup
Room: British Ballroom


Sunday, March 28 | 1:00PM - 10:00PM
Poster Viewing
Room: British Ballroom


Sunday, March 28 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: British Columbia Foyer


Sunday, March 28 | 5:00PM - 7:00PM
Mechanisms of Protein/Lipid Sorting by Lipid Domains
Room: Columbia Ballroom

Speaker 1 of 4
Richard E. Pagano, Mayo Clinic and Foundation, USA
Perturbation of Membrane Recycling by Stored Cholesterol in Niemann Pick Fibroblasts

Sunday, March 28 | 5:00PM - 7:00PM
Mechanisms of Protein/Lipid Sorting by Lipid Domains
Room: Columbia Ballroom

Speaker 2 of 4
Amy Chang, University of Michigan, USA
The Role of Lipid Rafts in Targeting to and Stability at the Yeast Plasma Membrane

Sunday, March 28 | 5:00PM - 7:00PM
Mechanisms of Protein/Lipid Sorting by Lipid Domains
Room: Columbia Ballroom

Speaker 3 of 4
* Scott D. Emr, Cornell University, USA
Lipid-Based Signaling in Endosomal Protein Sorting

Sunday, March 28 | 5:00PM - 7:00PM
Mechanisms of Protein/Lipid Sorting by Lipid Domains
Room: Columbia Ballroom

Speaker 4 of 4
Rutilio A. Fratti, University of Illinois at Urbana-Champaign, USA
Short Talk: Phosphoinositide Enrichment at the Vertex Ring Domain of Yeast Vacuoles is Required for Functional SNARE Distribution and Membrane Fusion

Sunday, March 28 | 7:00PM - 8:00PM
Social Hour
Room: British Ballroom


Sunday, March 28 | 7:30PM - 10:00PM
Poster Session 2: Mechanisms of Protein/Lipid Sorting by Lip
id Domains/Role of Lipids in Protein Sorting/Intracellular Traffic of Lipid Domains
Room: British Ballroom


Monday, March 29 | 7:00AM - 8:00AM
Breakfast
Room: British Ballroom


Monday, March 29 | 8:00AM - 11:00AM
Role of Lipids in Protein Sorting
Room: Columbia Ballroom

Speaker 1 of 5
* Joseph L. Goldstein, University of Texas Southwestern Medical Center, USA
Insig-Dependent, Sterol-Regulated Membrane Proteins: Part I – SCAP

Monday, March 29 | 8:00AM - 11:00AM
Role of Lipids in Protein Sorting
Room: Columbia Ballroom

Speaker 2 of 5
* Michael S. Brown, University of Texas Southwestern Medical Center, USA
Insig-Dependent, Sterol-Regulated Membrane Proteins: Part II - HMG CoA Reductase

Monday, March 29 | 8:00AM - 11:00AM
Role of Lipids in Protein Sorting
Room: Columbia Ballroom

Speaker 3 of 5
Ian Collinson, University of Bristol, UK
Structure and Function of a Protein Conducting Channel

Monday, March 29 | 8:00AM - 11:00AM
Role of Lipids in Protein Sorting
Room: Columbia Ballroom

Speaker 4 of 5
Howard Riezman, University of Geneva, Switzerland
Mechanisms of GPI-Anchored Protein Sorting Upon Exit from the Endoplasmic Reticulum

Monday, March 29 | 8:00AM - 11:00AM
Role of Lipids in Protein Sorting
Room: Columbia Ballroom

Speaker 5 of 5
Tetsuya Takeda, Columbia University Medical Center, USA
Short Talk: Organization of a Sterol-Rich Membrane Domain by cdc15p during Cytokinesis in Fission Yeast

Monday, March 29 | 9:20AM - 9:40AM
Coffee Break
Room: British Columbia Foyer


Monday, March 29 | 11:00AM - 1:00PM
Poster Setup
Room: British Ballroom


Monday, March 29 | 1:00PM - 10:00PM
Poster Viewing
Room: British Ballroom


Monday, March 29 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: British Columbia Foyer


Monday, March 29 | 5:00PM - 7:00PM
Intracellular Traffic of Lipid Domains
Room: Columbia Ballroom

Speaker 1 of 4
* Deborah A. Brown, Stony Brook University, USA
Palmitoylation and Intracellular-Domain Interactions Both Contribute to Raft Targeting of Linker for Activation of T Cells (LAT)

Monday, March 29 | 5:00PM - 7:00PM
Intracellular Traffic of Lipid Domains
Room: Columbia Ballroom

Speaker 2 of 4
Robert G. Parton, University of Queensland, Australia
Ultrastructural Analysis of Caveolae and Lipid Raft Domains


Monday, March 29 | 5:00PM - 7:00PM
Intracellular Traffic of Lipid Domains
Room: Columbia Ballroom

Speaker 3 of 4
Jennifer A. Lippincott-Schwartz, Howard Hughes Medical Institute - Janelia Farm, USA
The Golgi Apparatus: A Two Phase Membrane System for Protein Processing, Sorting and Secretory Transport

Monday, March 29 | 5:00PM - 7:00PM
Intracellular Traffic of Lipid Domains
Room: Columbia Ballroom

Speaker 4 of 4
Leslie T. Grab, University of North Carolina at Chapel Hill, USA
Short Talk: Exosomes Provide a Conduit for Extracellular Production of Lysophosphatidic Acid by Ovarian Cancer Cells

Monday, March 29 | 7:00PM - 8:00PM
Social Hour
Room: British Ballroom


Monday, March 29 | 7:30PM - 10:00PM
Poster Session 3: Signal Transduction from Lipid Domains/Rol
e of Lipid Domains in Disease
Room: British Ballroom


Tuesday, March 30 | 7:00AM - 8:00AM
Breakfast
Room: British Ballroom


Tuesday, March 30 | 8:00AM - 11:15AM
Signal Transduction from Lipid Domains
Room: Columbia Ballroom

Speaker 1 of 6
* Linda J. Pike, Washington University School of Medicine, USA
Lipid Rafts and EGF Receptor Signaling

Tuesday, March 30 | 8:00AM - 11:15AM
Signal Transduction from Lipid Domains
Room: Columbia Ballroom

Speaker 2 of 6
Susan K. Pierce, NIAID, National Institutes of Health, USA
The Role of Lipid Domains in Regulating Immune Cell Signaling

Tuesday, March 30 | 8:00AM - 11:15AM
Signal Transduction from Lipid Domains
Room: Columbia Ballroom

Speaker 3 of 6
Philip A. Beachy, HHMI/Stanford University, USA
Cholesterol Anchors and Signal Transduction

Tuesday, March 30 | 8:00AM - 11:15AM
Signal Transduction from Lipid Domains
Room: Columbia Ballroom

Speaker 4 of 6
Suzanne Eaton, Max Planck Institute, Germany
Argosomes: Lipidic Particles that Carry Wingless and Hedgehog

Tuesday, March 30 | 8:00AM - 11:15AM
Signal Transduction from Lipid Domains
Room: Columbia Ballroom

Speaker 5 of 6
Oleg O. Glebov, MRC Laboratory of Molecular Biology, UK
Short Talk: Lipid Raft Proteins have a Random Distribution during Localized Activation of T-Cell Receptor

Tuesday, March 30 | 8:00AM - 11:15AM
Signal Transduction from Lipid Domains
Room: Columbia Ballroom

Speaker 6 of 6
Cynthia Corley Mastick, University of Nevada, USA
Short Talk: Feedback Inhibition of Src Family Kinases through Phosphorylation of Caveolin-1 and Recruitment of Csk

Tuesday, March 30 | 9:20AM - 9:40AM
Coffee Break
Room: British Columbia Foyer


Tuesday, March 30 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: British Columbia Foyer


Tuesday, March 30 | 5:00PM - 7:00PM
Role of Lipid Domains in Disease
Room: Columbia Ballroom

Speaker 1 of 5
* Ari Helenius, ETH Zurich, Switzerland
What Viruses Tell Us About Endocytosis

Tuesday, March 30 | 5:00PM - 7:00PM
Role of Lipid Domains in Disease
Room: Columbia Ballroom

Speaker 2 of 5
Soman N. Abraham, Duke University Medical Center, USA
Lipid Raft Mediated Entry and Escape of E.coli from Host Cells

Tuesday, March 30 | 5:00PM - 7:00PM
Role of Lipid Domains in Disease
Room: Columbia Ballroom

Speaker 3 of 5
Alessandra Cambi, Max Planck Institute for Biophysical Chemistry, Germany
Short Talk: Microdomains of DC-Sign are Portals for Virus Entry into Dendritic Cells

Tuesday, March 30 | 5:00PM - 7:00PM
Role of Lipid Domains in Disease
Room: Columbia Ballroom

Speaker 4 of 5
Dan J. Sillence, UK
Short Talk: The Accumulation of Glycosphingolipids in Niemann-Pick C Disease Disrupts Endosomal Transport

Tuesday, March 30 | 5:00PM - 7:00PM
Role of Lipid Domains in Disease
Room: Columbia Ballroom

Speaker 5 of 5
Maho Morishima-Kawashima, Hokkaido University, Japan
Short Talk: Gamma-Secretase Activity to Generate Abeta is Present in Rafts, but not Cholesterol-Dependent

Tuesday, March 30 | 7:00PM - 8:00PM
Social Hour
Room: British Ballroom


Tuesday, March 30 | 8:00PM - 11:00PM
Entertainment
Room: British Ballroom


Tuesday, March 30 | 8:00PM - 11:00PM
Cash Bar
Room: British Ballroom


Wednesday, March 31 | 10:26AM - 10:26AM
Departure


*Session Chair.