Web Desc
Jaks and Stats: Development to Disease
Organizer(s): Robert D. Schreiber, David E. Levy and John J. O'Shea
Date: April 15 - 20, 2004
Location: Fairmont Chateau Whistler, Whistler, BC, Canada
Sponsored in part by the Director's Sponsor Fund
Summary of Meeting:
The study of the Jak-Stat signaling pathway has now reached an extremely sophisticated level. Nevertheless, significant new insights continue to rapidly emerge involving either novel pathway components or novel actions of known pathway components that have profound influences on signaling through both the Jak-Stat pathway as well as other signaling pathways. Recent work has also shown that Jak and Stats are evolutionarily conserved signaling molecules that regulate a diverse group of fundamental processes ranging from stem cell renewal and embryogenesis to organogenesis and development of hematopoietic and lymphoid cells. Furthermore their roles in preventing or promoting infectious, malignant and autoimmune diseases have now become areas of intense study and exciting new findings are being made in these areas that have wide applicability to several fields of biology. The goals of this meeting are as follows: -Identify novel interactions between members of the Jak-Stat pathway not only with one another but also with receptors and components of other signal transduction pathways with special emphasis on positive and negative acting mechanisms that regulate Jak-Stat pathway signaling. -Define the roles of the Jak-Stat pathway and its components in development of primitive and higher organisms with special emphasis being placed on model genetic organisms and on the hematopoietic and immune systems. -Discuss the various protective versus disease-promoting effects of the Jak-Stat signaling pathway in infectious and neoplastic diseases.
Discounted Abstract Deadline: December 16 2003
Discounted Registration Deadline: February 17 2004
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA108074-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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Program

Thursday, April 15 | 3:00PM - 7:00PM
Registration
Room: Macdonald Foyer


Thursday, April 15 | 6:15PM - 7:15PM
Refreshments
Room: Macdonald C


Thursday, April 15 | 7:15PM - 7:30PM
Orientation
Room: Macdonald AB


Thursday, April 15 | 7:30PM - 8:30PM
Keynote Address
Room: Macdonald AB

Speaker 1 of 1
James E. Darnell, Rockefeller University, USA
Integrating STATs in Transcriptional and Developmental Function

Friday, April 16 | 7:00AM - 8:00AM
Breakfast
Room: Macdonald C


Friday, April 16 | 8:00AM - 11:00AM
Jaks and Receptors
Room: Macdonald AB

Speaker 1 of 5
John J. O'Shea, NIAMS, National Institutes of Health, USA
Cytokine Signaling and Lymphoid Development, Differentiation and Immunoregulation

Friday, April 16 | 8:00AM - 11:00AM
Jaks and Receptors
Room: Macdonald AB

Speaker 2 of 5
* Sandra Pellegrini, Institut Pasteur, France
Jaks and Cytokine Receptor Traffic

Friday, April 16 | 8:00AM - 11:00AM
Jaks and Receptors
Room: Macdonald AB

Speaker 3 of 5
Peter C. Heinrich, RWTH Aachen University Hospital, Germany
IL-6-type Cytokine Receptor-JAK-STAT-Interactions and Modulation of Signaling

Friday, April 16 | 8:00AM - 11:00AM
Jaks and Receptors
Room: Macdonald AB

Speaker 4 of 5
Christin Carter-Su, University of Michigan Medical School, USA
Short Talk: Sites of JAK2 Autophosphorylation and Their Function in Cytokine Signaling

Friday, April 16 | 8:00AM - 11:00AM
Jaks and Receptors
Room: Macdonald AB

Speaker 5 of 5
Paul J. Hertzog, Hudson Institute of Medical Research, Australia
Short Talk: SOCI Regulation of Signalling through the Type IIFN Receptor

Friday, April 16 | 9:20AM - 9:40AM
Coffee Break
Room: Macdonald Foyer


Friday, April 16 | 11:00AM - 1:00PM
Poster Setup
Room: Macdonald C


Friday, April 16 | 1:00PM - 10:00PM
Poster Viewing
Room: Macdonald C


Friday, April 16 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Macdonald Foyer


Friday, April 16 | 5:00PM - 7:00PM
Stats: Structure and Function
Room: Macdonald AB

Speaker 1 of 4
George R. Stark, Case Western Reserve University, USA
Role of Unphosphorylated STAT3 in Cancer and in Response to Cytokines

Friday, April 16 | 5:00PM - 7:00PM
Stats: Structure and Function
Room: Macdonald AB

Speaker 2 of 4
* Nancy C. Reich, Stony Brook University, USA
Regulation of STAT Nuclear Trafficking

Friday, April 16 | 5:00PM - 7:00PM
Stats: Structure and Function
Room: Macdonald AB

Speaker 3 of 4
Christian W. Schindler, Columbia University, USA
Wrestling with IFNs - Wrestling with SUMO

Friday, April 16 | 5:00PM - 7:00PM
Stats: Structure and Function
Room: Macdonald AB

Speaker 4 of 4
Friedemann Horn, Universitat Leipzig, Germany
Short Talk: Stat3 Serine Phosphorylation Reevaluated

Friday, April 16 | 7:00PM - 8:00PM
Social Hour
Room: Macdonald C


Friday, April 16 | 7:30PM - 10:00PM
Poster Session 1
Room: Macdonald C


Saturday, April 17 | 7:00AM - 8:00AM
Breakfast
Room: Macdonald C


Saturday, April 17 | 8:00AM - 11:00AM
Negative Regulation
Room: Macdonald AB

Speaker 1 of 5
* Douglas J. Hilton, Walter and Eliza Hall Institute of Medical Research, Australia
SOCS Proteins Regulate the Quantity and Quality of Jak/Stat Signaling


Saturday, April 17 | 8:00AM - 11:00AM
Negative Regulation
Room: Macdonald AB

Speaker 2 of 5
Akihiko Yoshimura, Keio University, Japan
SOCS1 and SOCS3; Key Positive and Negative Regulators for Macrophage and Dendritic Cell Activation

Saturday, April 17 | 8:00AM - 11:00AM
Negative Regulation
Room: Macdonald AB

Speaker 3 of 5
Ke Shuai, University of California, Los Angeles, USA
Negative Regulation of Cytokine Signaling in the Nucleus

Saturday, April 17 | 8:00AM - 11:00AM
Negative Regulation
Room: Macdonald AB

Speaker 4 of 5
Benjamin G. Neel, Ontario Cancer Institute, Canada
Role of Shp2 in Normal and Abnormal Hematopoiesis

Saturday, April 17 | 8:00AM - 11:00AM
Negative Regulation
Room: Macdonald AB

Speaker 5 of 5
Michelle Ann Soriano, Harvard School of Public Health, USA
Short Talk: Isolation and Characterization of a Novel Negative Regulator of STAT4 Signaling

Saturday, April 17 | 9:20AM - 9:40AM
Coffee Break
Room: Macdonald Foyer


Saturday, April 17 | 11:00AM - 1:00PM
Poster Setup
Room: Macdonald C


Saturday, April 17 | 1:00PM - 10:00PM
Poster Viewing
Room: Macdonald C


Saturday, April 17 | 2:00PM - 4:00PM
Workshop 1: IRFs and Other Transcription Factors
Room: Macdonald AB

Speaker 1 of 6
* Keiko Ozato, NICHD, National Institutes of Health, USA
IRFs as Downstream Effectors of Stat-Dependent Biologic Responses

Saturday, April 17 | 2:00PM - 4:00PM
Workshop 1: IRFs and Other Transcription Factors
Room: Macdonald AB

Speaker 2 of 6
Isabelle J. Marie, New York University School of Medicine, USA
Activation of IRF7 during Pathogen Infection: Kinases, Phosphorylation Sites and Regulatory Mechanisms

Saturday, April 17 | 2:00PM - 4:00PM
Workshop 1: IRFs and Other Transcription Factors
Room: Macdonald AB

Speaker 3 of 6
Niamh E. Buckley, Queen's University, UK
IRF-7 Plays a Key Role in the BRCA 1/Interferon Gamma Mediated Apoptotic Response

Saturday, April 17 | 2:00PM - 4:00PM
Workshop 1: IRFs and Other Transcription Factors
Room: Macdonald AB

Speaker 4 of 6
Oanh Dang, University of California, San Diego, USA
Anthrax Lethal Toxin Inhibits Activation of Interferon Regulatory Factor 3 by LPS

Saturday, April 17 | 2:00PM - 4:00PM
Workshop 1: IRFs and Other Transcription Factors
Room: Macdonald AB

Speaker 5 of 6
Mirjam J. Eckert, University of Lausanne, Switzerland
The Extreme C-Terminus of IRF-1 has an effect on its Transcriptional Activity

Saturday, April 17 | 2:00PM - 4:00PM
Workshop 1: IRFs and Other Transcription Factors
Room: Macdonald AB

Speaker 6 of 6
Lisa N. Haubein, University of Pennsylvania, USA
Regulation of Stat5 Function by c-Myb

Saturday, April 17 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Macdonald Foyer


Saturday, April 17 | 5:00PM - 7:00PM
Jak-Stat Pathway in Non-Mammalian Development
Room: Macdonald AB

Speaker 1 of 4
* Norbert Perrimon, Harvard Medical School, USA
Drosophila JAK/STAT Pathway and Septic Injury

Saturday, April 17 | 5:00PM - 7:00PM
Jak-Stat Pathway in Non-Mammalian Development
Room: Macdonald AB

Speaker 2 of 4
Jeffrey G. Williams, University of Dundee, School of Biological Sciences, UK
Functional Analysis of the Four Dictyostelium STAT Proteins and a Crystal Structure for Activated Dd-STATa in its DNA-Unbound Form

Saturday, April 17 | 5:00PM - 7:00PM
Jak-Stat Pathway in Non-Mammalian Development
Room: Macdonald AB

Speaker 3 of 4
Toshio Hirano, Osaka University Graduate School of Medicine, Japan
Jaks and Stats in Epithelial-Mesenchymal Transition of Zebrafish Gastrula Organizer

Saturday, April 17 | 5:00PM - 7:00PM
Jak-Stat Pathway in Non-Mammalian Development
Room: Macdonald AB

Speaker 4 of 4
Erika A. Bach, New York University School of Medicine, USA
Short Talk: Epidermal Growth Factor Receptor (Egfr) Signaling in the Drosophila Embryo Requires a Functional JAK/STAT Pathway

Saturday, April 17 | 7:00PM - 8:00PM
Social Hour
Room: Macdonald C


Saturday, April 17 | 7:30PM - 10:00PM
Poster Session 2
Room: Macdonald C


Sunday, April 18 | 7:00AM - 8:00AM
Breakfast
Room: Macdonald C


Sunday, April 18 | 8:00AM - 11:00AM
Jak-Stat Pathway in Mammalian Development
Room: Macdonald AB

Speaker 1 of 5
James N. Ihle, St. Jude Children's Research Hospital, USA
Stat5 Function Revisited

Sunday, April 18 | 8:00AM - 11:00AM
Jak-Stat Pathway in Mammalian Development
Room: Macdonald AB

Speaker 2 of 5
* Lothar Hennighausen, National Institutes of Health, USA
Cell-Specific and Temporal Inactivation of the Stat5 Locus in the Mouse

Sunday, April 18 | 8:00AM - 11:00AM
Jak-Stat Pathway in Mammalian Development
Room: Macdonald AB

Speaker 3 of 5
Christine J. Watson, University of Cambridge, UK
Short Talk: The Multiple Roles of Stat Factors, and their Downstream Effectors, in Regulating Differentiation, Apoptosis and Remodeling in Mammary Gland

Sunday, April 18 | 8:00AM - 11:00AM
Jak-Stat Pathway in Mammalian Development
Room: Macdonald AB

Speaker 4 of 5
Michael A. Farrar, University of Minnesota, USA
Short Talk: Differential Regulation of B and T Cell Development by STAT5

Sunday, April 18 | 8:00AM - 11:00AM
Jak-Stat Pathway in Mammalian Development
Room: Macdonald AB

Speaker 5 of 5
Valeria Poli, University of Turin, Italy
Short Talk: Non-Redundant Functions of STAT3alpha and STAT3beta revealed by Specific Ablation of Either Isoform

Sunday, April 18 | 9:20AM - 9:40AM
Coffee Break
Room: Macdonald Foyer


Sunday, April 18 | 11:00AM - 1:00PM
Poster Setup
Room: Macdonald C


Sunday, April 18 | 1:00PM - 10:00PM
Poster Viewing
Room: Macdonald C


Sunday, April 18 | 2:00PM - 4:00PM
Workshop 2: New Cytokines, Cytokine Receptors and Signaling
Regulators
Room: Macdonald AB

Speaker 1 of 7
* Paul B. Rothman, University of Iowa, USA

Sunday, April 18 | 2:00PM - 4:00PM
Workshop 2: New Cytokines, Cytokine Receptors and Signaling
Regulators
Room: Macdonald AB

Speaker 2 of 7
Alexander S. Banks, Harvard Medical School, USA
Suppressor of Cytokine Signaling-7 Deficiency Results in Decreased Body Size, Increased Growth of Pancreatic Islets, and Altered Glucose Homeostasis

Sunday, April 18 | 2:00PM - 4:00PM
Workshop 2: New Cytokines, Cytokine Receptors and Signaling
Regulators
Room: Macdonald AB

Speaker 3 of 7
Christine Brender, St. Vincent's Institute of Medical Research, Australia
Regulation of T Cell Homeostasis by SOCS1 and SOCS3

Sunday, April 18 | 2:00PM - 4:00PM
Workshop 2: New Cytokines, Cytokine Receptors and Signaling
Regulators
Room: Macdonald AB

Speaker 4 of 7
Andrei Thomas-Tikhonenko, Children's Hospital of Philadelphia and University of Pennsylvania, USA
An Essential Role of Th1 Responses and Interferon gamma/STAT1 Signaling in Infection-Mediated Anti-Angiogenesis and Suppression of Neoplastic Growth

Sunday, April 18 | 2:00PM - 4:00PM
Workshop 2: New Cytokines, Cytokine Receptors and Signaling
Regulators
Room: Macdonald AB

Speaker 5 of 7
Ana P. Costa-Pereira, Cancer Research UK, UK
Novel Signaling Requirements for the Class II HLA and Antiviral Responses to Interferon-gamma

Sunday, April 18 | 2:00PM - 4:00PM
Workshop 2: New Cytokines, Cytokine Receptors and Signaling
Regulators
Room: Macdonald AB

Speaker 6 of 7
Alejandro Villarino, University of Miami, USA
The IL-27R (WSX-1) is Required to Suppress Effector T Cell Functions during Infection

Sunday, April 18 | 2:00PM - 4:00PM
Workshop 2: New Cytokines, Cytokine Receptors and Signaling
Regulators
Room: Macdonald AB

Speaker 7 of 7
Pravin B. Sehgal, New York Medical College, USA
Disruption of Endothelial-Cell Caveolin-1/Raft Scaffolding and STAT3 Activation in the Lung during Development of Monocrotaline-Induced Pulmonary Hypertension

Sunday, April 18 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Macdonald Foyer


Sunday, April 18 | 5:00PM - 7:00PM
Jak-Stat Pathway in Immune Regulation
Room: Macdonald AB

Speaker 1 of 5
* Kenneth M. Murphy, HHMI/Washington University School of Medicine, USA
Stats in T Helper Cell Development


Sunday, April 18 | 5:00PM - 7:00PM
Jak-Stat Pathway in Immune Regulation
Room: Macdonald AB

Speaker 2 of 5
Xiaomin Chen, University of Texas MD Anderson Cancer Center, USA
Short Talk: Structural and Biochemical Studies of STAT Proteins

Sunday, April 18 | 5:00PM - 7:00PM
Jak-Stat Pathway in Immune Regulation
Room: Macdonald AB

Speaker 3 of 5
Olli J. Silvennoinen, University of Tampere, Finland
Short Talk: Regulation of Jaks and Stats in Cytokine Receptor Signaling

Sunday, April 18 | 5:00PM - 7:00PM
Jak-Stat Pathway in Immune Regulation
Room: Macdonald AB

Speaker 4 of 5
Azad Bonni, Harvard Medical School, USA
Short Talk: Deregulation of the LIFRbeta-STAT3 Signaling Pathway In Brain Tumors

Sunday, April 18 | 5:00PM - 7:00PM
Jak-Stat Pathway in Immune Regulation
Room: Macdonald AB

Speaker 5 of 5
Mariusz A. Wasik, University of Pennsylvania, USA
Short Talk: Stat3-Mediated Epigenetic Silencing of SHP-1 Phosphatase Expression in Malignant T-Cell

Sunday, April 18 | 7:00PM - 8:00PM
Social Hour
Room: Macdonald C


Sunday, April 18 | 7:30PM - 10:00PM
Poster Session 3
Room: Macdonald C


Monday, April 19 | 7:00AM - 8:00AM
Breakfast
Room: Macdonald C


Monday, April 19 | 8:00AM - 11:00AM
Jak-Stat Pathway in Cancer
Room: Macdonald AB

Speaker 1 of 5
Robert D. Schreiber, Washington University School of Medicine, USA
Stat 1 and Cancer Immunoediting

Monday, April 19 | 8:00AM - 11:00AM
Jak-Stat Pathway in Cancer
Room: Macdonald AB

Speaker 2 of 5
David E. Levy, New York University School of Medicine, USA
Multiple Distinct Mechanisms Underline the Role of Stat3 in Malignant Transformation

Monday, April 19 | 8:00AM - 11:00AM
Jak-Stat Pathway in Cancer
Room: Macdonald AB

Speaker 3 of 5
* Jacqueline F. Bromberg, Memorial Sloan Kettering Cancer Center, USA
Stats and Tumorigenesis in Epithelial Cells - Breast and Prostate Cancer

Monday, April 19 | 8:00AM - 11:00AM
Jak-Stat Pathway in Cancer
Room: Macdonald AB

Speaker 4 of 5
Richard Jove, Vaccine & Gene Therapy Institute of Florida, USA
Stats as Novel Targets for Cancer Therapy

Monday, April 19 | 8:00AM - 11:00AM
Jak-Stat Pathway in Cancer
Room: Macdonald AB

Speaker 5 of 5
Jennifer Rubin Grandis, University of Pittsburgh Eye & Ear Institute, USA
Short Talk: STAT Alterations in Head and Neck Cancer

Monday, April 19 | 9:20AM - 9:40AM
Coffee Break
Room: Macdonald Foyer


Monday, April 19 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Macdonald Foyer


Monday, April 19 | 5:00PM - 7:00PM
Jak-Stat Pathway in Infectious Disease
Room: Macdonald AB

Speaker 1 of 4
Jean-Laurent Casanova, Rockefeller University, USA
Inherited Disorders of Human Stat-1 and Infectious Diseases

Monday, April 19 | 5:00PM - 7:00PM
Jak-Stat Pathway in Infectious Disease
Room: Macdonald AB

Speaker 2 of 4
* Thomas A.F. Decker, Vienna Biocenter, University of Vienna, Austria
Interferons and Stats in Machrophage Responses to Intracellular Bacteria

Monday, April 19 | 5:00PM - 7:00PM
Jak-Stat Pathway in Infectious Disease
Room: Macdonald AB

Speaker 3 of 4
Christine A. Biron, Brown University, USA
STATs in Immune Responses to Viral Infections - Type 1 IFNs

Monday, April 19 | 5:00PM - 7:00PM
Jak-Stat Pathway in Infectious Disease
Room: Macdonald AB

Speaker 4 of 4
Curt M. Horvath, Northwestern University, USA
Short Talk: Viral Coalitions Uncover Weapons of STAT Destruction

Monday, April 19 | 7:00PM - 8:00PM
Social Hour
Room: Macdonald C


Monday, April 19 | 8:00PM - 11:00PM
Entertainment
Room: Macdonald C


Monday, April 19 | 8:00PM - 11:00PM
Cash Bar
Room: Macdonald C


Tuesday, April 20 | 10:26AM - 10:26AM
Departure


*Session Chair.