Web Desc
Human Genome Sequence Variation and the Inherited Basis of Common Disease
joint with Natural Variation and Quantitative Genetics in Model Organisms
Organizer(s): David M. Altshuler, Lon Cardon and Leonid Kruglyak
Date: January 08 - 13, 2004
Location: Beaver Run Resort, Breckenridge, CO, USA
Supported by Keystone Symposia
Summary of Meeting:
The goal of this meeting is to understand patterns of sequence variation in the human genome and how they impact biology and disease. Specifically, the meeting will explore how genome sequences and patterns of gene expression vary in populations, and the forces that shaped these patterns (both molecular and demographic). We will review approaches to studying complex traits in both model systems and in human populations, including the genetic architecture of common human diseases. Finally, we will review recent examples of genetic contributions to common human diseases, and the impact of such information on biology, pharmaceutical development and medicine. The goal of the joint meetings is to bring together scientists and perspectives from population genetics, quantitative genetics, human genetics, genomics and epidemiology. The synthesis of these capabilities and frameworks will surely be required to make progress in the genetic analysis of common human disease.
Discounted Abstract Deadline: October 15 2003
Discounted Registration Deadline: November 10 2003
We gratefully acknowledge additional support for this conference from:
Crohn
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Thursday, January 08 | 3:00PM - 7:00PM
Registration
Room: Foyer


Thursday, January 08 | 6:15PM - 7:15PM
Refreshments
Room: Foyer


Thursday, January 08 | 7:15PM - 7:30PM
Orientation
Room: Peaks 4-5


Thursday, January 08 | 7:30PM - 9:30PM
Keynote Session: Genetic Dissection of Complex Traits (Joint
)
Room: Peaks 4-5

Speaker 1 of 4
* David M. Altshuler, Vertex Pharmaceuticals Incorporated, USA

Thursday, January 08 | 7:30PM - 9:30PM
Keynote Session: Genetic Dissection of Complex Traits (Joint
)
Room: Peaks 4-5

Speaker 2 of 4
* Detlef Weigel, Max Planck Institute for Developmental Biology, Germany

Thursday, January 08 | 7:30PM - 9:30PM
Keynote Session: Genetic Dissection of Complex Traits (Joint
)
Room: Peaks 4-5

Speaker 3 of 4
Charles H. Langley, University of California, Davis, USA
Polymorphism and Divergence Across the Drosophila Genome

Thursday, January 08 | 7:30PM - 9:30PM
Keynote Session: Genetic Dissection of Complex Traits (Joint
)
Room: Peaks 4-5

Speaker 4 of 4
Aravinda Chakravarti, Johns Hopkins University School of Medicine, USA
The Nature of Variation in Complex Disease

Friday, January 09 | 7:00AM - 8:00AM
Breakfast
Room: Peaks 6-12


Friday, January 09 | 8:00AM - 11:00AM
Patterns of Human Genome Sequence Variation
Room: Peaks 4-5

Speaker 1 of 5
* Peter Donnelly, University of Oxford and Genomics plc, UK

Friday, January 09 | 8:00AM - 11:00AM
Patterns of Human Genome Sequence Variation
Room: Peaks 4-5

Speaker 2 of 5
Mark Daly, Massachusetts General Hospital, USA
Human Haplotype Structure

Friday, January 09 | 8:00AM - 11:00AM
Patterns of Human Genome Sequence Variation
Room: Peaks 4-5

Speaker 3 of 5
Lon Cardon, University of Oxford, UK
Haplotype Structure Across Chromosomes

Friday, January 09 | 8:00AM - 11:00AM
Patterns of Human Genome Sequence Variation
Room: Peaks 4-5

Speaker 4 of 5
Kelly A. Frazer, University of California San Diego School of Medicine, USA
Genetic Variation and Human Disease

Friday, January 09 | 8:00AM - 11:00AM
Patterns of Human Genome Sequence Variation
Room: Peaks 4-5

Speaker 5 of 5
Andrew G. Clark, Cornell University, USA
Lessons from Candidate Gene Studies about the Genetics of Complex Traits

Friday, January 09 | 8:00AM - 11:00AM
QTL in Animals I
This session is from Quantitative Genetics
Room: Peaks 1-3

Speaker 1 of 5
* Trudy F.C. Mackay, North Carolina State University, USA


Friday, January 09 | 8:00AM - 11:00AM
QTL in Animals I
This session is from Quantitative Genetics
Room: Peaks 1-3

Speaker 2 of 5
Catherine (Katie) L. Peichel, Fred Hutchinson Cancer Research Center, USA
Genetic Analysis of Reproductive Isolation in Sticklebacks


Friday, January 09 | 8:00AM - 11:00AM
QTL in Animals I
This session is from Quantitative Genetics
Room: Peaks 1-3

Speaker 3 of 5
Peter D. Keightley, University of Edinburgh, UK
Analysing Quantitative Genetic Variation for Growth in Mice


Friday, January 09 | 8:00AM - 11:00AM
QTL in Animals I
This session is from Quantitative Genetics
Room: Peaks 1-3

Speaker 4 of 5
Kari J. Buck, Oregon Health & Science University, USA
Genetic Control of Physical Dependence and Associated Withdrawal Episodes in Mice


Friday, January 09 | 8:00AM - 11:00AM
QTL in Animals I
This session is from Quantitative Genetics
Room: Peaks 1-3

Speaker 5 of 5
Thomas E. Johnson, University of Colorado, USA
QTLs in Mice and Worms; Use of Recombinant Inbred Strains


Friday, January 09 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Friday, January 09 | 11:00AM - 1:00PM
Poster Setup
Room: Peaks 14-16


Friday, January 09 | 1:00PM - 10:00PM
Poster Viewing
Room: Peaks 14-16


Friday, January 09 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Foyer


Friday, January 09 | 5:00PM - 7:00PM
Exploiting Inbred Strains to Find Complex Traits (Joint)
Room: Peaks 4-5

Speaker 1 of 4
* Peter D. Keightley, University of Edinburgh, UK

Friday, January 09 | 5:00PM - 7:00PM
Exploiting Inbred Strains to Find Complex Traits (Joint)
Room: Peaks 4-5

Speaker 2 of 4
Keith R. Davis, Icoria, Inc, USA
High-Throughput Plant Gene Function Analysis in Arabidopsis

Friday, January 09 | 5:00PM - 7:00PM
Exploiting Inbred Strains to Find Complex Traits (Joint)
Room: Peaks 4-5

Speaker 3 of 4
Wayne Frankel, The Jackson Laboratory, USA
Effects of Genetic Background on Induced and Spontaneous Mouse Models for Epilepsy

Friday, January 09 | 5:00PM - 7:00PM
Exploiting Inbred Strains to Find Complex Traits (Joint)
Room: Peaks 4-5

Speaker 4 of 4
Michael P. Snyder, Stanford University School of Medicine, USA
Identification of Functional Regions in the Genomes of Yeast and Humans

Friday, January 09 | 6:45PM - 7:20PM
Comparative Genomics

Speaker 1 of 1
Eric S. Lander, Massachusetts Institute of Technology, USA

Friday, January 09 | 7:20PM - 8:00PM
Social Hour
Room: Peaks 14-16


Friday, January 09 | 7:30PM - 10:00PM
Poster Session 1
Room: Peaks 14-16


Saturday, January 10 | 7:00AM - 8:00AM
Breakfast
Room: Peaks 6-12


Saturday, January 10 | 8:00AM - 11:00AM
Molecular Forces Shaping Genome Sequence Variation
Room: Peaks 4-5

Speaker 1 of 6
* Andrew G. Clark, Cornell University, USA

Saturday, January 10 | 8:00AM - 11:00AM
Molecular Forces Shaping Genome Sequence Variation
Room: Peaks 4-5

Speaker 2 of 6
Peter Donnelly, University of Oxford and Genomics plc, UK
Understanding Fine-Scale Variation in Recombination Rates

Saturday, January 10 | 8:00AM - 11:00AM
Molecular Forces Shaping Genome Sequence Variation
Room: Peaks 4-5

Speaker 3 of 6
Richard Hudson, University of Chicago, USA
Fine-Scale Mapping with Linkage Disequilibrium

Saturday, January 10 | 8:00AM - 11:00AM
Molecular Forces Shaping Genome Sequence Variation
Room: Peaks 4-5

Speaker 4 of 6
Chris Toomajian, University of Southern California, USA
The Pattern of Polymorphism in the Arabidopsis Genome

Saturday, January 10 | 8:00AM - 11:00AM
Molecular Forces Shaping Genome Sequence Variation
Room: Peaks 4-5

Speaker 5 of 6
Evan E. Eichler, HHMI/University of Washington, USA
Structural Variation and Large-Scale Polymorphism within Segmental Duplications

Saturday, January 10 | 8:00AM - 11:00AM
Molecular Forces Shaping Genome Sequence Variation
Room: Peaks 4-5

Speaker 6 of 6
Richard M. Durbin, Wellcome Trust Sanger Institute, UK
Short Talk: Significant Correspondence of Recombination Events in Pedigrees with Haplotype Block Boundaries

Saturday, January 10 | 8:00AM - 11:00AM
QTL in Animals II
This session is from Quantitative Genetics
Room: Peaks 1-3

Speaker 1 of 5
* Catherine (Katie) L. Peichel, Fred Hutchinson Cancer Research Center, USA


Saturday, January 10 | 8:00AM - 11:00AM
QTL in Animals II
This session is from Quantitative Genetics
Room: Peaks 1-3

Speaker 2 of 5
Trudy F.C. Mackay, North Carolina State University, USA
Molecular Quantitative Genetics of Drosophila Life Span


Saturday, January 10 | 8:00AM - 11:00AM
QTL in Animals II
This session is from Quantitative Genetics
Room: Peaks 1-3

Speaker 3 of 5
Chung-I Wu, Chinese Academy of Sciences, China
Molecular Genetics of Speciation


Saturday, January 10 | 8:00AM - 11:00AM
QTL in Animals II
This session is from Quantitative Genetics
Room: Peaks 1-3

Speaker 4 of 5
John H. Werren, University of Rochester, USA
Evolutionary Genetics of Species Differences in Nasonia


Saturday, January 10 | 8:00AM - 11:00AM
QTL in Animals II
This session is from Quantitative Genetics
Room: Peaks 1-3

Speaker 5 of 5
Marta L. Wayne, University of Florida, USA
Sex Dimorphism and Non-Additivity in Gene Expression in Drosophila melanogaster


Saturday, January 10 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Saturday, January 10 | 11:00AM - 1:00PM
Poster Setup
Room: Peaks 14-16


Saturday, January 10 | 1:00PM - 10:00PM
Poster Viewing
Room: Peaks 14-16


Saturday, January 10 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Foyer


Saturday, January 10 | 5:00PM - 7:00PM
Population History and Human Sequence Variation
Room: Peaks 4-5

Speaker 1 of 4
* Stephen J. O'Brien, National Cancer Institute, National Institutes of Health, USA

Saturday, January 10 | 5:00PM - 7:00PM
Population History and Human Sequence Variation
Room: Peaks 4-5

Speaker 2 of 4
David B. Goldstein, Duke University, USA
Haployptes, Human History, and Pharmacogenetics

Saturday, January 10 | 5:00PM - 7:00PM
Population History and Human Sequence Variation
Room: Peaks 4-5

Speaker 3 of 4
John Raelson, Galileo Genomics, Canada
Short Talk: General Extent of LD in the Quebec Founder Population

Saturday, January 10 | 5:00PM - 7:00PM
Population History and Human Sequence Variation
Room: Peaks 4-5

Speaker 4 of 4
Mark Patterson, Public Library of Science, UK
Short Talk: Public Library of Science

Saturday, January 10 | 5:00PM - 7:00PM
QTL in Plants I
This session is from Quantitative Genetics
Room: Peaks 1-3

Speaker 1 of 4
* Joanne Chory, The Salk Institute, USA


Saturday, January 10 | 5:00PM - 7:00PM
QTL in Plants I
This session is from Quantitative Genetics
Room: Peaks 1-3

Speaker 2 of 4
Masahiro Yano, National Institute of Agrobiological Resources, Japan
Natural Variation in Flowering Time in Rice


Saturday, January 10 | 5:00PM - 7:00PM
QTL in Plants I
This session is from Quantitative Genetics
Room: Peaks 1-3

Speaker 3 of 4
Leonie C. Moyle, University of California, Davis, USA
Salad Speciation: Genetics of Species Differences and Hybrid Incompatibility in Lycopersicon


Saturday, January 10 | 5:00PM - 7:00PM
QTL in Plants I
This session is from Quantitative Genetics
Room: Peaks 1-3

Speaker 4 of 4
Justin O. Borevitz, University of Chicago, USA
Towards the Arabidopsis Haplotype Map Using Arrays


Saturday, January 10 | 7:00PM - 8:00PM
Social Hour
Room: Peaks 14-16


Saturday, January 10 | 7:30PM - 10:00PM
Poster Session 2
Room: Peaks 14-16


Sunday, January 11 | 7:00AM - 8:00AM
Breakfast
Room: Peaks 6-12


Sunday, January 11 | 8:00AM - 11:00AM
Inherited Variation in Gene Expression (Joint)
Room: Peaks 4-5

Speaker 1 of 5
* Leonid Kruglyak, Princeton University, USA
Regulatory Variation in Yeast

Sunday, January 11 | 8:00AM - 11:00AM
Inherited Variation in Gene Expression (Joint)
Room: Peaks 4-5

Speaker 2 of 5
Kevin P. White, Tempus, Inc., USA
Evolution of Gene Expression in Drosophila

Sunday, January 11 | 8:00AM - 11:00AM
Inherited Variation in Gene Expression (Joint)
Room: Peaks 4-5

Speaker 3 of 5
Stephanie Monks, University of Washington, USA
The Genetics of Gene Expression in Mice

Sunday, January 11 | 8:00AM - 11:00AM
Inherited Variation in Gene Expression (Joint)
Room: Peaks 4-5

Speaker 4 of 5
Justin Fay, Washington University, USA
Short Talk: Genetic Variation in Gene Expression is Associated with Phenotypic Variation Sequence Divergence

Sunday, January 11 | 8:00AM - 11:00AM
Inherited Variation in Gene Expression (Joint)
Room: Peaks 4-5

Speaker 5 of 5
Matthew Rockman, New York University, USA
Short Talk: Cis-Regulated Polymorphism: Evolution, Natural Variation, and Common Disease

Sunday, January 11 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Sunday, January 11 | 11:00AM - 1:00PM
Poster Setup
Room: Peaks 14-16


Sunday, January 11 | 1:00PM - 10:00PM
Poster Viewing
Room: Peaks 14-16


Sunday, January 11 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Foyer


Sunday, January 11 | 5:00PM - 7:00PM
Genetic Architecture of Human Disease
Room: Peaks 4-5

Speaker 1 of 6
* Lon Cardon, University of Oxford, UK

Sunday, January 11 | 5:00PM - 7:00PM
Genetic Architecture of Human Disease
Room: Peaks 4-5

Speaker 2 of 6
Stephen J. O'Brien, National Cancer Institute, National Institutes of Health, USA
Architecture of Disease: Lessons from HIV Resistance

Sunday, January 11 | 5:00PM - 7:00PM
Genetic Architecture of Human Disease
Room: Peaks 4-5

Speaker 3 of 6
Nicholas Katsanis, Northwestern University Feinberg School of Medicine, USA
Modeling Oligogenic Disorders

Sunday, January 11 | 5:00PM - 7:00PM
Genetic Architecture of Human Disease
Room: Peaks 4-5

Speaker 4 of 6
John A. Phillips, Vanderbilt University School of Medicine, USA
Short Talk: PPH is a Complex Disease Caused by Rare and Common Variants

Sunday, January 11 | 5:00PM - 7:00PM
Genetic Architecture of Human Disease
Room: Peaks 4-5

Speaker 5 of 6
Hua Tang, University of Chicago, USA
Short Talk: Genetic Diseases and Natural Selection in Human

Sunday, January 11 | 5:00PM - 7:00PM
Genetic Architecture of Human Disease
Room: Peaks 4-5

Speaker 6 of 6
Örjan Carlborg, Roslin Institute, UK
Short Talk: The Use of Epistasis in Genetic Dissection of Complex Traits

Sunday, January 11 | 5:00PM - 7:00PM
QTL in Plants II
This session is from Quantitative Genetics
Room: Peaks 1-3

Speaker 1 of 5
* Masahiro Yano, National Institute of Agrobiological Resources, Japan


Sunday, January 11 | 5:00PM - 7:00PM
QTL in Plants II
This session is from Quantitative Genetics
Room: Peaks 1-3

Speaker 2 of 5
Joanne Chory, The Salk Institute, USA
and


Sunday, January 11 | 5:00PM - 7:00PM
QTL in Plants II
This session is from Quantitative Genetics
Room: Peaks 1-3

Speaker 3 of 5
Olivier Loudet, Institut National de La Recherche Agronomique, France
Natural Variation in Light Signaling in Arabidopsis


Sunday, January 11 | 5:00PM - 7:00PM
QTL in Plants II
This session is from Quantitative Genetics
Room: Peaks 1-3

Speaker 4 of 5
Carlos Alonso-Blanco, Centro Nacional de Biotecnologia, CSIC, Spain
Natural Variation for Life History Traits in Arabidopsis


Sunday, January 11 | 5:00PM - 7:00PM
QTL in Plants II
This session is from Quantitative Genetics
Room: Peaks 1-3

Speaker 5 of 5
Dani Zamir, Cornell University, USA
Real Time QTL of Tomato Yield


Sunday, January 11 | 7:00PM - 8:00PM
Social Hour
Room: Peaks 14-16


Sunday, January 11 | 7:30PM - 10:00PM
Poster Session 3
Room: Peaks 14-16


Monday, January 12 | 7:00AM - 8:00AM
Breakfast
Room: Peaks 6-12


Monday, January 12 | 8:00AM - 11:00AM
Genetic Determinants of Common Disease
Room: Peaks 4-5

Speaker 1 of 5
* Francis S. Collins, Director, National Institutes of Health, USA

Monday, January 12 | 8:00AM - 11:00AM
Genetic Determinants of Common Disease
Room: Peaks 4-5

Speaker 2 of 5
Richard P. Lifton, HHMI/Yale University School of Medicine, USA
Genetic Dissection of Hypertension

Monday, January 12 | 8:00AM - 11:00AM
Genetic Determinants of Common Disease
Room: Peaks 4-5

Speaker 3 of 5
Gilles Thomas, NCI - National Institutes of Health, USA
The Genetics of CARD15, a Susceptibility Gene for an Inflammatory Bowel Disease

Monday, January 12 | 8:00AM - 11:00AM
Genetic Determinants of Common Disease
Room: Peaks 4-5

Speaker 4 of 5
David M. Altshuler, Vertex Pharmaceuticals Incorporated, USA
Genetic Analysis of Diabetes

Monday, January 12 | 8:00AM - 11:00AM
Genetic Determinants of Common Disease
Room: Peaks 4-5

Speaker 5 of 5
David Hunter, Harvard Medical School, USA
Gene-Environment Interactions

Monday, January 12 | 8:00AM - 11:00AM
Evolution of Adaptive Traits
This session is from Quantitative Genetics
Room: Peaks 1-3

Speaker 1 of 5
* Neelima Sinha, University of California, Davis, USA


Monday, January 12 | 8:00AM - 11:00AM
Evolution of Adaptive Traits
This session is from Quantitative Genetics
Room: Peaks 1-3

Speaker 2 of 5
June B. Nasrallah, Cornell University, USA
Diversification of Self-Incompatibility Genes in the Brassicaceae


Monday, January 12 | 8:00AM - 11:00AM
Evolution of Adaptive Traits
This session is from Quantitative Genetics
Room: Peaks 1-3

Speaker 3 of 5
Thomas Mitchell-Olds, Duke University, USA
Nucleotide Polymorphism and Quantitative Trait Variation in Arabidopsis and Related Species


Monday, January 12 | 8:00AM - 11:00AM
Evolution of Adaptive Traits
This session is from Quantitative Genetics
Room: Peaks 1-3

Speaker 4 of 5
Sean B. Carroll, University of Wisconsin-Madison, USA
Genetic and Developmental Mechanisms Underlying Divergent and Convergent Patterns of Evolution


Monday, January 12 | 8:00AM - 11:00AM
Evolution of Adaptive Traits
This session is from Quantitative Genetics
Room: Peaks 1-3

Speaker 5 of 5
Ying Tan, University of Massachusetts-Boston, USA
Molecular Evolution of Color Vision Genes in Primates


Monday, January 12 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Monday, January 12 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Foyer


Monday, January 12 | 5:00PM - 7:00PM
Application to Biology, Medicine and Society
Room: Peaks 4-5

Speaker 1 of 4
* Richard P. Lifton, HHMI/Yale University School of Medicine, USA

Monday, January 12 | 5:00PM - 7:00PM
Application to Biology, Medicine and Society
Room: Peaks 4-5

Speaker 2 of 4
Georgia Dunston, Howard University, USA
The GRAD Biobank: A Resource for Exploring Genome Variation and Environment Interaction in Common Complex Diseases

Monday, January 12 | 5:00PM - 7:00PM
Application to Biology, Medicine and Society
Room: Peaks 4-5

Speaker 3 of 4
Klaus Lindpaintner, F. Hoffmann-La Roche AG, Switzerland
Pharmacogenetics: A Realistic View

Monday, January 12 | 5:00PM - 7:00PM
Application to Biology, Medicine and Society
Room: Peaks 4-5

Speaker 4 of 4
Francis S. Collins, Director, National Institutes of Health, USA
Applying Genetics to Medicine and Society

Monday, January 12 | 5:00PM - 7:00PM
Variation between Distant Taxa
This session is from Quantitative Genetics
Room: Peaks 1-3

Speaker 1 of 4
* Ying Tan, University of Massachusetts-Boston, USA


Monday, January 12 | 5:00PM - 7:00PM
Variation between Distant Taxa
This session is from Quantitative Genetics
Room: Peaks 1-3

Speaker 2 of 4
Nipam H. Patel, University of California, Berkeley, USA
The Evolution of Arthropod Pattern Formation


Monday, January 12 | 5:00PM - 7:00PM
Variation between Distant Taxa
This session is from Quantitative Genetics
Room: Peaks 1-3

Speaker 3 of 4
Neelima Sinha, University of California, Davis, USA
The Development and Evolution of Leaves


Monday, January 12 | 5:00PM - 7:00PM
Variation between Distant Taxa
This session is from Quantitative Genetics
Room: Peaks 1-3

Speaker 4 of 4
Marie-Anne Felix, Institut Jacques Monod, France
Evolution of Nematode Vulva Development: A Microevolutionary Approach


Monday, January 12 | 7:00PM - 8:00PM
Social Hour
Room: Peaks 14-16


Monday, January 12 | 8:00PM - 11:00PM
Entertainment
Room: Peaks 4-5


Monday, January 12 | 8:00PM - 11:00PM
Cash Bar
Room: Peaks 4-5


Tuesday, January 13 | 10:26AM - 10:26AM
Departure


*Session Chair.