Web Desc
Natural Variation and Quantitative Genetics in Model Organisms
joint with Human Genome Sequence Variation and the Inherited Basis of Common Disease
Organizer(s): Detlef Weigel and Bruce Walsh
Date: January 08 - 13, 2004
Location: Beaver Run Resort, Breckenridge, CO, USA
Supported by Keystone Symposia
For important information on the coronavirus, please click here
Summary of Meeting:
Despite tremendous advances in the genetic analysis of many biological processes, the molecular basis of the variation seen within and between species remains largely unknown. ·Standard genetic analyses in model organisms have focused on laboratory-induced mutations with large phenotypic effects, which contrasts with the variation seen in natural populations, which is mostly continuous. The phenotypic variation seen within or between closely related species also contrasts with the phenotypic variation seen between more distantly related species. It seems likely, however, that intra- and interspecific variation are two sides of the same coin, although a unifying molecular framework has not yet been developed. Now is an exciting time to revisit these questions because of several major technological advances. These include new analytical tools, such as high-throughput genotyping, new statistical and computational methods, comprehensive transcriptome and proteome profiling, as well as opportunities to compare entire genomes between closely and distantly related organisms. Understanding the molecular basis of natural variation has important implications both for understanding the evolution of new traits, as well as for understanding how selection has shaped genomes, including the human genome. The meeting will have as a major focus both animal and plant model organisms, in which the use of quantitative genetics is experiencing a renaissance. The molecular study of Quantitative Trait Loci, several of which have been traced back to individual genes, is allowing important conclusions as to the type of genes and type of changes that underlie quantitative phenotypic variation. A second focus of the meeting will be recent discoveries of how changes in key regulatory factors cause major phenotypic differences in more distantly related taxa. The overall goal of this meeting is to bring together a diverse group of investigators that includes scientists interested in the evolution of developmental diversity, quantitative geneticists and population geneticists. ·Finally, the proposed meeting, which will focus on genetic model organisms such as Drosophila and Arabidopsis, will be an excellent complement to the meeting that is to be held concurrently, on Human Genetic Diversity.
Discounted Abstract Deadline: October 15 2003
Discounted Registration Deadline: November 10 2003
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of General Medical Sciences (NIGMS)
Grant No. 1R13 GM070207-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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Program

Thursday, January 08 | 3:00PM - 7:00PM
Registration
Room: Foyer


Thursday, January 08 | 6:15PM - 7:15PM
Refreshments
Room: Foyer


Thursday, January 08 | 7:15PM - 7:30PM
Orientation
Room: Peaks 4-5


Thursday, January 08 | 7:30PM - 9:30PM
Keynote Session: Genetic Dissection of Complex Traits (Joint
)
Room: Peaks 4-5

Speaker 1 of 4
* David M. Altshuler, Vertex Pharmaceuticals Incorporated, USA

Thursday, January 08 | 7:30PM - 9:30PM
Keynote Session: Genetic Dissection of Complex Traits (Joint
)
Room: Peaks 4-5

Speaker 2 of 4
* Detlef Weigel, Max Planck Institute for Developmental Biology, Germany

Thursday, January 08 | 7:30PM - 9:30PM
Keynote Session: Genetic Dissection of Complex Traits (Joint
)
Room: Peaks 4-5

Speaker 3 of 4
Charles H. Langley, University of California, Davis, USA
Polymorphism and Divergence Across the Drosophila Genome

Thursday, January 08 | 7:30PM - 9:30PM
Keynote Session: Genetic Dissection of Complex Traits (Joint
)
Room: Peaks 4-5

Speaker 4 of 4
Aravinda Chakravarti, Johns Hopkins University School of Medicine, USA
The Nature of Variation in Complex Disease

Friday, January 09 | 7:00AM - 8:00AM
Breakfast
Room: Peaks 6-12


Friday, January 09 | 8:00AM - 11:00AM
QTL in Animals I
Room: Peaks 1-3

Speaker 1 of 5
* Trudy F.C. Mackay, North Carolina State University, USA

Friday, January 09 | 8:00AM - 11:00AM
QTL in Animals I
Room: Peaks 1-3

Speaker 2 of 5
Catherine (Katie) L. Peichel, Fred Hutchinson Cancer Research Center, USA
Genetic Analysis of Reproductive Isolation in Sticklebacks

Friday, January 09 | 8:00AM - 11:00AM
QTL in Animals I
Room: Peaks 1-3

Speaker 3 of 5
Peter D. Keightley, University of Edinburgh, UK
Analysing Quantitative Genetic Variation for Growth in Mice

Friday, January 09 | 8:00AM - 11:00AM
QTL in Animals I
Room: Peaks 1-3

Speaker 4 of 5
Kari J. Buck, Oregon Health & Science University, USA
Genetic Control of Physical Dependence and Associated Withdrawal Episodes in Mice

Friday, January 09 | 8:00AM - 11:00AM
QTL in Animals I
Room: Peaks 1-3

Speaker 5 of 5
Thomas E. Johnson, University of Colorado, USA
QTLs in Mice and Worms; Use of Recombinant Inbred Strains


Friday, January 09 | 8:00AM - 11:00AM
Patterns of Human Genome Sequence Variation
This session is from Human Genome Sequence Variatio
Room: Peaks 4-5

Speaker 1 of 5
* Peter Donnelly, University of Oxford and Genomics plc, UK


Friday, January 09 | 8:00AM - 11:00AM
Patterns of Human Genome Sequence Variation
This session is from Human Genome Sequence Variatio
Room: Peaks 4-5

Speaker 2 of 5
Mark Daly, Massachusetts General Hospital, USA
Human Haplotype Structure


Friday, January 09 | 8:00AM - 11:00AM
Patterns of Human Genome Sequence Variation
This session is from Human Genome Sequence Variatio
Room: Peaks 4-5

Speaker 3 of 5
Lon Cardon, University of Oxford, UK
Haplotype Structure Across Chromosomes


Friday, January 09 | 8:00AM - 11:00AM
Patterns of Human Genome Sequence Variation
This session is from Human Genome Sequence Variatio
Room: Peaks 4-5

Speaker 4 of 5
Kelly A. Frazer, University of California San Diego School of Medicine, USA
Genetic Variation and Human Disease


Friday, January 09 | 8:00AM - 11:00AM
Patterns of Human Genome Sequence Variation
This session is from Human Genome Sequence Variatio
Room: Peaks 4-5

Speaker 5 of 5
Andrew G. Clark, Cornell University, USA
Lessons from Candidate Gene Studies about the Genetics of Complex Traits


Friday, January 09 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Friday, January 09 | 11:00AM - 1:00PM
Poster Setup
Room: Peaks 14-16


Friday, January 09 | 1:00PM - 10:00PM
Poster Viewing
Room: Peaks 14-16


Friday, January 09 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Foyer


Friday, January 09 | 5:00PM - 7:00PM
Exploiting Inbred Strains to Understand Complex Traits (Join
t)

Room: Peaks 4-5

Speaker 1 of 4
* Peter D. Keightley, University of Edinburgh, UK

Friday, January 09 | 5:00PM - 7:00PM
Exploiting Inbred Strains to Understand Complex Traits (Join
t)

Room: Peaks 4-5

Speaker 2 of 4
Keith R. Davis, Icoria, Inc, USA
High-Throughput Plant Gene Function Analysis in Arabidopsis

Friday, January 09 | 5:00PM - 7:00PM
Exploiting Inbred Strains to Understand Complex Traits (Join
t)

Room: Peaks 4-5

Speaker 3 of 4
Wayne Frankel, The Jackson Laboratory, USA
Effects of Genetic Background on Induced and Spontaneous, Monogenic and Polygenic Models for Epilepsy in Mice

Friday, January 09 | 5:00PM - 7:00PM
Exploiting Inbred Strains to Understand Complex Traits (Join
t)

Room: Peaks 4-5

Speaker 4 of 4
Michael P. Snyder, Stanford University School of Medicine, USA
Identification of Functional Regions in the Genomes of Yeast and Humans

Friday, January 09 | 6:45PM - 7:20PM
Comparative Genomics

Speaker 1 of 1
Eric S. Lander, Massachusetts Institute of Technology, USA

Friday, January 09 | 7:20PM - 8:00PM
Social Hour
Room: Peaks 14-16


Friday, January 09 | 7:30PM - 10:00PM
Poster Session 1
Room: Peaks 14-16


Saturday, January 10 | 7:00AM - 8:00AM
Breakfast
Room: Peaks 6-12


Saturday, January 10 | 8:00AM - 11:00AM
QTL in Animals II
Room: Peaks 1-3

Speaker 1 of 5
* Catherine (Katie) L. Peichel, Fred Hutchinson Cancer Research Center, USA

Saturday, January 10 | 8:00AM - 11:00AM
QTL in Animals II
Room: Peaks 1-3

Speaker 2 of 5
Trudy F.C. Mackay, North Carolina State University, USA
Molecular Quantitative Genetics of Drosophila Life Span

Saturday, January 10 | 8:00AM - 11:00AM
QTL in Animals II
Room: Peaks 1-3

Speaker 3 of 5
Chung-I Wu, Chinese Academy of Sciences, China
Molecular Genetics of Speciation

Saturday, January 10 | 8:00AM - 11:00AM
QTL in Animals II
Room: Peaks 1-3

Speaker 4 of 5
John H. Werren, University of Rochester, USA
Evolutionary Genetics of Species Differences in Nasonia

Saturday, January 10 | 8:00AM - 11:00AM
QTL in Animals II
Room: Peaks 1-3

Speaker 5 of 5
Marta L. Wayne, University of Florida, USA
Sex Dimorphism and Non-Additivity in Gene Expression in Drosophila melanogaster

Saturday, January 10 | 8:00AM - 11:00AM
Molecular Forces Shaping Genome Sequence Variation
This session is from Human Genome Sequence Variatio
Room: Peaks 4-5

Speaker 1 of 6
* Andrew G. Clark, Cornell University, USA


Saturday, January 10 | 8:00AM - 11:00AM
Molecular Forces Shaping Genome Sequence Variation
This session is from Human Genome Sequence Variatio
Room: Peaks 4-5

Speaker 2 of 6
Peter Donnelly, University of Oxford and Genomics plc, UK
Understanding Fine-Scale Variation in Recombination Rates


Saturday, January 10 | 8:00AM - 11:00AM
Molecular Forces Shaping Genome Sequence Variation
This session is from Human Genome Sequence Variatio
Room: Peaks 4-5

Speaker 3 of 6
Richard Hudson, University of Chicago, USA
Fine-Scale Mapping with Linkage Disequilibrium


Saturday, January 10 | 8:00AM - 11:00AM
Molecular Forces Shaping Genome Sequence Variation
This session is from Human Genome Sequence Variatio
Room: Peaks 4-5

Speaker 4 of 6
Chris Toomajian, University of Southern California, USA
The Pattern of Polymorphism in the Arabidopsis Genome


Saturday, January 10 | 8:00AM - 11:00AM
Molecular Forces Shaping Genome Sequence Variation
This session is from Human Genome Sequence Variatio
Room: Peaks 4-5

Speaker 5 of 6
Evan E. Eichler, HHMI/University of Washington, USA
Structural Variation and Large-Scale Polymorphism within Segmental Duplications


Saturday, January 10 | 8:00AM - 11:00AM
Molecular Forces Shaping Genome Sequence Variation
This session is from Human Genome Sequence Variatio
Room: Peaks 4-5

Speaker 6 of 6
Richard M. Durbin, Wellcome Trust Sanger Institute, UK
Short Talk: Significant Correspondence of Recombination Events in Pedigrees with Haplotype Block Boundaries


Saturday, January 10 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Saturday, January 10 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Foyer


Saturday, January 10 | 5:00PM - 7:00PM
QTL in Plants I
Room: Peaks 1-3

Speaker 1 of 4
* Joanne Chory, The Salk Institute, USA

Saturday, January 10 | 5:00PM - 7:00PM
QTL in Plants I
Room: Peaks 1-3

Speaker 2 of 4
Masahiro Yano, National Institute of Agrobiological Resources, Japan
Natural Variation in Flowering Time in Rice

Saturday, January 10 | 5:00PM - 7:00PM
QTL in Plants I
Room: Peaks 1-3

Speaker 3 of 4
Leonie C. Moyle, University of California, Davis, USA
Salad Speciation: Genetics of Species Differences and Hybrid Incompatibility in Lycopersicon

Saturday, January 10 | 5:00PM - 7:00PM
QTL in Plants I
Room: Peaks 1-3

Speaker 4 of 4
Justin O. Borevitz, University of Chicago, USA
Towards the Arabidopsis Haplotype Map Using Arrays

Saturday, January 10 | 5:00PM - 7:00PM
Population History and Human Sequence Variation
This session is from Human Genome Sequence Variatio
Room: Peaks 4-5

Speaker 1 of 4
* Stephen J. O'Brien, National Cancer Institute, National Institutes of Health, USA


Saturday, January 10 | 5:00PM - 7:00PM
Population History and Human Sequence Variation
This session is from Human Genome Sequence Variatio
Room: Peaks 4-5

Speaker 2 of 4
David B. Goldstein, Duke University, USA
Haployptes, Human History, and Pharmacogenetics


Saturday, January 10 | 5:00PM - 7:00PM
Population History and Human Sequence Variation
This session is from Human Genome Sequence Variatio
Room: Peaks 4-5

Speaker 3 of 4
John Raelson, Galileo Genomics, Canada
Short Talk: General Extent of LD in the Quebec Founder Population


Saturday, January 10 | 5:00PM - 7:00PM
Population History and Human Sequence Variation
This session is from Human Genome Sequence Variatio
Room: Peaks 4-5

Speaker 4 of 4
Mark Patterson, Public Library of Science, UK
Short Talk: Public Library of Science


Saturday, January 10 | 7:00PM - 8:00PM
Social Hour
Room: Peaks 14-16


Sunday, January 11 | 7:00AM - 8:00AM
Breakfast
Room: Peaks 6-12


Sunday, January 11 | 8:00AM - 11:00AM
Inherited Variation in Gene Expression (Joint)
Room: Peaks 4-5

Speaker 1 of 5
* Leonid Kruglyak, Princeton University, USA
Regulatory Variation in Yeast

Sunday, January 11 | 8:00AM - 11:00AM
Inherited Variation in Gene Expression (Joint)
Room: Peaks 4-5

Speaker 2 of 5
Kevin P. White, Tempus, Inc., USA
Evolution of Gene Expression in Drosophila

Sunday, January 11 | 8:00AM - 11:00AM
Inherited Variation in Gene Expression (Joint)
Room: Peaks 4-5

Speaker 3 of 5
Stephanie Monks, University of Washington, USA
The Genetics of Gene Expression in Mice

Sunday, January 11 | 8:00AM - 11:00AM
Inherited Variation in Gene Expression (Joint)
Room: Peaks 4-5

Speaker 4 of 5
Justin Fay, Washington University, USA
Short Talk: Genetic Variation in Gene Expression is Associated with Phenotypic Variation Sequence Divergence

Sunday, January 11 | 8:00AM - 11:00AM
Inherited Variation in Gene Expression (Joint)
Room: Peaks 4-5

Speaker 5 of 5
Matthew Rockman, New York University, USA
Short Talk: Cis-Regulated Polymorphism: Evolution, Natural Variation, and Common Disease

Sunday, January 11 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Sunday, January 11 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Foyer


Sunday, January 11 | 5:00PM - 7:00PM
QTL in Plants II
Room: Peaks 1-3

Speaker 1 of 5
* Masahiro Yano, National Institute of Agrobiological Resources, Japan

Sunday, January 11 | 5:00PM - 7:00PM
QTL in Plants II
Room: Peaks 1-3

Speaker 2 of 5
Joanne Chory, The Salk Institute, USA
and

Sunday, January 11 | 5:00PM - 7:00PM
QTL in Plants II
Room: Peaks 1-3

Speaker 3 of 5
Olivier Loudet, Institut National de La Recherche Agronomique, France
Natural Variation in Light Signaling in Arabidopsis

Sunday, January 11 | 5:00PM - 7:00PM
QTL in Plants II
Room: Peaks 1-3

Speaker 4 of 5
Carlos Alonso-Blanco, Centro Nacional de Biotecnologia, CSIC, Spain
Natural Variation for Life History Traits in Arabidopsis

Sunday, January 11 | 5:00PM - 7:00PM
QTL in Plants II
Room: Peaks 1-3

Speaker 5 of 5
Dani Zamir, Cornell University, USA
Real Time QTL of Tomato Yield

Sunday, January 11 | 5:00PM - 7:00PM
Genetic Architecture of Human Disease
This session is from Human Genome Sequence Variatio
Room: Peaks 4-5

Speaker 1 of 6
* Lon Cardon, University of Oxford, UK


Sunday, January 11 | 5:00PM - 7:00PM
Genetic Architecture of Human Disease
This session is from Human Genome Sequence Variatio
Room: Peaks 4-5

Speaker 2 of 6
Stephen J. O'Brien, National Cancer Institute, National Institutes of Health, USA
Architecture of Disease: Lessons from HIV Resistance


Sunday, January 11 | 5:00PM - 7:00PM
Genetic Architecture of Human Disease
This session is from Human Genome Sequence Variatio
Room: Peaks 4-5

Speaker 3 of 6
Nicholas Katsanis, Northwestern University Feinberg School of Medicine, USA
Modeling Oligogenic Disorders


Sunday, January 11 | 5:00PM - 7:00PM
Genetic Architecture of Human Disease
This session is from Human Genome Sequence Variatio
Room: Peaks 4-5

Speaker 4 of 6
John A. Phillips, Vanderbilt University School of Medicine, USA
Short Talk: PPH is a Complex Disease Caused by Rare and Common Variants


Sunday, January 11 | 5:00PM - 7:00PM
Genetic Architecture of Human Disease
This session is from Human Genome Sequence Variatio
Room: Peaks 4-5

Speaker 5 of 6
Hua Tang, University of Chicago, USA
Short Talk: Genetic Diseases and Natural Selection in Human


Sunday, January 11 | 5:00PM - 7:00PM
Genetic Architecture of Human Disease
This session is from Human Genome Sequence Variatio
Room: Peaks 4-5

Speaker 6 of 6
Örjan Carlborg, Roslin Institute, Scotland
Short Talk: The Use of Epistasis in Genetic Dissection of Complex Traits


Sunday, January 11 | 7:00PM - 8:00PM
Social Hour
Room: Peaks 14-16


Monday, January 12 | 7:00AM - 8:00AM
Breakfast
Room: Peaks 6-12


Monday, January 12 | 8:00AM - 11:00AM
Evolution of Adaptive Traits
Room: Peaks 1-3

Speaker 1 of 5
* Neelima Sinha, University of California, Davis, USA

Monday, January 12 | 8:00AM - 11:00AM
Evolution of Adaptive Traits
Room: Peaks 1-3

Speaker 2 of 5
June B. Nasrallah, Cornell University, USA
Diversification of Self-Incompatibility Genes in the Brassicaceae

Monday, January 12 | 8:00AM - 11:00AM
Evolution of Adaptive Traits
Room: Peaks 1-3

Speaker 3 of 5
Thomas Mitchell-Olds, Duke University, USA
Nucleotide Polymorphism and Quantitative Trait Variation in Arabidopsis and Related Species

Monday, January 12 | 8:00AM - 11:00AM
Evolution of Adaptive Traits
Room: Peaks 1-3

Speaker 4 of 5
Sean B. Carroll, University of Wisconsin-Madison, USA
Genetic and Developmental Mechanisms Underlying Divergent and Convergent Patterns of Evolution

Monday, January 12 | 8:00AM - 11:00AM
Evolution of Adaptive Traits
Room: Peaks 1-3

Speaker 5 of 5
Ying Tan, University of Massachusetts-Boston, USA
Molecular Evolution of Color Vision Genes in Primates

Monday, January 12 | 8:00AM - 11:00AM
Genetic Determinants of Common Disease
This session is from Human Genome Sequence Variatio
Room: Peaks 4-5

Speaker 1 of 5
* Francis S. Collins, Director, National Institutes of Health, USA


Monday, January 12 | 8:00AM - 11:00AM
Genetic Determinants of Common Disease
This session is from Human Genome Sequence Variatio
Room: Peaks 4-5

Speaker 2 of 5
Richard P. Lifton, HHMI/Yale University School of Medicine, USA
Genetic Dissection of Hypertension


Monday, January 12 | 8:00AM - 11:00AM
Genetic Determinants of Common Disease
This session is from Human Genome Sequence Variatio
Room: Peaks 4-5

Speaker 3 of 5
Gilles Thomas, NCI - National Institutes of Health, USA
The Genetics of CARD15, a Susceptibility Gene for an Inflammatory Bowel Disease


Monday, January 12 | 8:00AM - 11:00AM
Genetic Determinants of Common Disease
This session is from Human Genome Sequence Variatio
Room: Peaks 4-5

Speaker 4 of 5
David M. Altshuler, Vertex Pharmaceuticals Incorporated, USA
Genetic Analysis of Diabetes


Monday, January 12 | 8:00AM - 11:00AM
Genetic Determinants of Common Disease
This session is from Human Genome Sequence Variatio
Room: Peaks 4-5

Speaker 5 of 5
David Hunter, Harvard Medical School, USA
Gene-Environment Interactions


Monday, January 12 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Monday, January 12 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Foyer


Monday, January 12 | 5:00PM - 7:00PM
Variation between Distant Taxa
Room: Peaks 1-3

Speaker 1 of 4
* Ying Tan, University of Massachusetts-Boston, USA

Monday, January 12 | 5:00PM - 7:00PM
Variation between Distant Taxa
Room: Peaks 1-3

Speaker 2 of 4
Nipam H. Patel, University of California, Berkeley, USA
The Evolution of Arthropod Pattern Formation

Monday, January 12 | 5:00PM - 7:00PM
Variation between Distant Taxa
Room: Peaks 1-3

Speaker 3 of 4
Neelima Sinha, University of California, Davis, USA
The Development and Evolution of Leaves

Monday, January 12 | 5:00PM - 7:00PM
Variation between Distant Taxa
Room: Peaks 1-3

Speaker 4 of 4
Marie-Anne Felix, Institut Jacques Monod, France
Evolution of Nematode Vulva Development: A Microevolutionary Approach

Monday, January 12 | 5:00PM - 7:00PM
Application to Biology, Medicine and Society
This session is from Human Genome Sequence Variatio
Room: Peaks 4-5

Speaker 1 of 4
* Richard P. Lifton, HHMI/Yale University School of Medicine, USA


Monday, January 12 | 5:00PM - 7:00PM
Application to Biology, Medicine and Society
This session is from Human Genome Sequence Variatio
Room: Peaks 4-5

Speaker 2 of 4
Georgia Dunston, Howard University, USA
The GRAD Biobank: A Resource for Exploring Genome Variation and Environment Interaction in Common Complex Diseases


Monday, January 12 | 5:00PM - 7:00PM
Application to Biology, Medicine and Society
This session is from Human Genome Sequence Variatio
Room: Peaks 4-5

Speaker 3 of 4
Klaus Lindpaintner, F. Hoffmann-La Roche AG, Switzerland
Pharmacogenetics: A Realistic View


Monday, January 12 | 5:00PM - 7:00PM
Application to Biology, Medicine and Society
This session is from Human Genome Sequence Variatio
Room: Peaks 4-5

Speaker 4 of 4
Francis S. Collins, Director, National Institutes of Health, USA
Applying Genetics to Medicine and Society


Monday, January 12 | 7:00PM - 8:00PM
Social Hour
Room: Peaks 14-16


Monday, January 12 | 8:00PM - 11:00PM
Entertainment
Room: Peaks 4-5


Monday, January 12 | 8:00PM - 11:00PM
Cash Bar
Room: Peaks 4-5


Tuesday, January 13 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.