Web Desc
Apoptosis in Development
joint with Apoptosis in Biochemistry and Structural Biology
Organizer(s): Michael O. Hengartner, Sally A. Kornbluth and Scott W. Lowe
Date: February 03 - 08, 2004
Location: Keystone Resort, Keystone, CO, USA
Supported by Keystone Symposia
Summary of Meeting:
The importance of apoptosis in disease development is well documented. However, its role in normal development is still lagging. Nevertheless, it is clear that apoptosis plays a crucial role in development, and that pathways that mediate developmental apoptosis are often mutated in disease. We now have a quite good understanding of the identity of the proteins that mediate apoptotic cell death. What are the roles of these proteins in normal development? How similar are the programs that mediate apoptotic cell death in different tissues? How similar are the death programs in different species? Many of the apoptotic proteins are conserved through evolution. Can one thus use information gained in one species to learn about apoptosis regulation in other species? Is apoptosis the only type of programmed cell death used during development in mammals? In other species? By bringing together scientists working on the same problem but in different systems (tissues and/or species), this meeting aims to: - Allow attendees to discern which genes and aspects of apoptosis are fundamental, and which might be system-specific. - Increase the transfer of knowledge between experimental systems - such that 'rules' established in one system can be tested and verified in others. - Encourage the study of apoptosis in development to better understand apoptotic pathways that can be altered in disease states.
Discounted Abstract Deadline: October 2 2003
Discounted Registration Deadline: December 3 2003
We gratefully acknowledge additional support for this conference from:
March of Dimes Foundation
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI58469-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, February 03 | 3:00PM - 7:00PM
Registration
Room: Longs Peak Foyer


Tuesday, February 03 | 6:15PM - 7:15PM
Refreshments
Room: Longs Peak Foyer


Tuesday, February 03 | 7:15PM - 7:30PM
Orientation
Room: Longs Peak


Tuesday, February 03 | 7:30PM - 8:30PM
Keynote Address
Room: Longs Peak

Speaker 1 of 1
Shigekazu Nagata, IFReC, Osaka University, Japan
A Role of DNA Degradation in Mammalian Development


Wednesday, February 04 | 7:00AM - 8:00AM
Breakfast
Room: Torreys/Grays


Wednesday, February 04 | 8:00AM - 11:00AM
Death of the Spineless - Apoptosis in Invertebrates
Room: Longs Peak

Speaker 1 of 5
John M. Abrams, University of Texas Southwestern Medical Center, USA
Dying like Flies: Programmed and Unprogrammed Cell Death in Drosophila

Wednesday, February 04 | 8:00AM - 11:00AM
Death of the Spineless - Apoptosis in Invertebrates
Room: Longs Peak

Speaker 2 of 5
Barbara Conradt, Ludwig-Maximilians-Universitat, Germany
Cell-Death Specification in C. elegans

Wednesday, February 04 | 8:00AM - 11:00AM
Death of the Spineless - Apoptosis in Invertebrates
Room: Longs Peak

Speaker 3 of 5
Kristin White, Harvard Medical School, USA
Apoptotic Pathways in Drosophila Development

Wednesday, February 04 | 8:00AM - 11:00AM
Death of the Spineless - Apoptosis in Invertebrates
Room: Longs Peak

Speaker 4 of 5
* Michael O. Hengartner, University of Zürich, Switzerland
Apoptotic Pathways in C. elegans


Wednesday, February 04 | 8:00AM - 11:00AM
Death of the Spineless - Apoptosis in Invertebrates
Room: Longs Peak

Speaker 5 of 5
Kristen Cullen, Cell Signaling Technology, USA
Short Talk: A Role for Programmed Cell Death in Patterning the Drosophila Arista

Wednesday, February 04 | 8:00AM - 11:00AM
Caspase Activation and Inhibition
This session is from Structural Biology of Apoptosi
Room: Quandry Peak

Speaker 1 of 4
Christopher W. Akey, Boston University School of Medicine, USA
Structure of the Human Apoptosome Determined by Electron Cryo-Microscopy


Wednesday, February 04 | 8:00AM - 11:00AM
Caspase Activation and Inhibition
This session is from Structural Biology of Apoptosi
Room: Quandry Peak

Speaker 2 of 4
* Guy S. Salvesen, Sanford-Burnham Medical Research Institute, USA
Mechanisms of Caspase Activation: Conservation and Variation


Wednesday, February 04 | 8:00AM - 11:00AM
Caspase Activation and Inhibition
This session is from Structural Biology of Apoptosi
Room: Quandry Peak

Speaker 3 of 4
Hao Wu, Harvard Medical School, Boston Children's Hospital, USA
Structural and Biochemical Studies of p35 and XIAP


Wednesday, February 04 | 8:00AM - 11:00AM
Caspase Activation and Inhibition
This session is from Structural Biology of Apoptosi
Room: Quandry Peak

Speaker 4 of 4
Bruce A. Hay, California Institute of Technology, USA
MicroRNA Regulators of Cell Death


Wednesday, February 04 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Wednesday, February 04 | 11:00AM - 1:00PM
Poster Setup
Room: Grays Peak


Wednesday, February 04 | 1:00PM - 10:00PM
Poster Viewing
Room: Grays Peak


Wednesday, February 04 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Longs Peak Foyer


Wednesday, February 04 | 5:00PM - 7:00PM
Developmental Role of Apoptotic Genes I
Room: Longs Peak

Speaker 1 of 4
* Sally A. Kornbluth, Duke University Medical Center, USA
Regulation of Apoptosis by Reaper

Wednesday, February 04 | 5:00PM - 7:00PM
Developmental Role of Apoptotic Genes I
Room: Longs Peak

Speaker 2 of 4
Juan M. Hurle, University of Cantabria, Spain
Apoptosis during Vertebrate Limb Development

Wednesday, February 04 | 5:00PM - 7:00PM
Developmental Role of Apoptotic Genes I
Room: Longs Peak

Speaker 3 of 4
Joel H. Rothman, University of California, Santa Barbara, USA
Apoptotic Suppression in C. elegans

Wednesday, February 04 | 5:00PM - 7:00PM
Developmental Role of Apoptotic Genes I
Room: Longs Peak

Speaker 4 of 4
Erick J. Morris, Massachusetts General Hospital, USA
Short Talk: Functional Identification of a Synthetic Lethal Interaction between Aac11 and the Rb-E2F Pathway

Wednesday, February 04 | 5:00PM - 7:00PM
Death Receptor Pathway
This session is from Structural Biology of Apoptosi
Room: Quandry Peak

Speaker 1 of 3
* Vishva M. Dixit, Genentech, Inc., USA
Identification and Characterization of c-Jun Ubiquitin Ligase in Arabidopsis Photomorphogenesis


Wednesday, February 04 | 5:00PM - 7:00PM
Death Receptor Pathway
This session is from Structural Biology of Apoptosi
Room: Quandry Peak

Speaker 2 of 3
Yvonne Yvonne Jones, University of Oxford, UK
Structural Mechanisms of Death Receptor Activation


Wednesday, February 04 | 5:00PM - 7:00PM
Death Receptor Pathway
This session is from Structural Biology of Apoptosi
Room: Quandry Peak

Speaker 3 of 3
Milton H. Werner, Celtaxsys, USA
Rethinking the Conformation of the Death-Inducing Signaling Complex: A Unified Theory for Death Motif Interactions


Wednesday, February 04 | 7:00PM - 8:00PM
Social Hour
Room: Longs Peak Foyer


Wednesday, February 04 | 7:30PM - 10:00PM
Poster Session 1
Room: Grays Peak


Thursday, February 05 | 7:00AM - 8:00AM
Breakfast
Room: Torreys/Grays


Thursday, February 05 | 8:00AM - 11:00AM
Developmental Roles of Apoptotic Genes II
Room: Longs Peak

Speaker 1 of 5
* Junying Yuan, Harvard Medical School, USA
The PHD Finger of the Chromatin-Associated Protein ING2 Functions as a Nuclear Phosphoinositide Receptor

Thursday, February 05 | 8:00AM - 11:00AM
Developmental Roles of Apoptotic Genes II
Room: Longs Peak

Speaker 2 of 5
Razq Hakem, University Health Network, Canada
Role of Caspase 8 in Proliferation and Survival

Thursday, February 05 | 8:00AM - 11:00AM
Developmental Roles of Apoptotic Genes II
Room: Longs Peak

Speaker 3 of 5
Francesco Cecconi, University of Rome Tor Vergata, Italy
The Centrality of the Apoptosome in Neurodevelopment

Thursday, February 05 | 8:00AM - 11:00AM
Developmental Roles of Apoptotic Genes II
Room: Longs Peak

Speaker 4 of 5
Andreas E. Strasser, Walter and Eliza Hall Institute of Medical Research, Australia
Role of BH3-Only Pro-Apoptotic Bcl-2 Family Mmembers in Programmed Cell Death and Pathology

Thursday, February 05 | 8:00AM - 11:00AM
Developmental Roles of Apoptotic Genes II
Room: Longs Peak

Speaker 5 of 5
Maryanne Donovan, University College Cork, Ireland
Short Talk: Transcriptional Regulation of Pro-Apoptotic Bcl-2 Family Members during Retinal Development and Distinct Pathways of Photoreceptor Cell Death

Thursday, February 05 | 8:00AM - 11:00AM
Mitochondria in Apoptosis
This session is from Structural Biology of Apoptosi
Room: Quandry Peak

Speaker 1 of 5
Yigong Shi, Tsinghua University School of Medicine, China
A Re-Evaluation of the Induced Proximity Model for Caspase Activation


Thursday, February 05 | 8:00AM - 11:00AM
Mitochondria in Apoptosis
This session is from Structural Biology of Apoptosi
Room: Quandry Peak

Speaker 2 of 5
* John C. Reed, Sanofi, France
Regulation of the ER Cell Death Pathway by BI-1


Thursday, February 05 | 8:00AM - 11:00AM
Mitochondria in Apoptosis
This session is from Structural Biology of Apoptosi
Room: Quandry Peak

Speaker 3 of 5
Yoshihide Tsujimoto, Osaka University Medical School, Japan
A Role of Mitochondria in Cell Death


Thursday, February 05 | 8:00AM - 11:00AM
Mitochondria in Apoptosis
This session is from Structural Biology of Apoptosi
Room: Quandry Peak

Speaker 4 of 5
Guido Kroemer, Cordeliers Research Center, France
Biochemical Characterization of AIF-Mediated Apoptosis


Thursday, February 05 | 8:00AM - 11:00AM
Mitochondria in Apoptosis
This session is from Structural Biology of Apoptosi
Room: Quandry Peak

Speaker 5 of 5
Xiao-Ming Yin, Indiana University SOM, USA
Short Talk: An Orchestrated Activation of Multiple Mitochondrial Apoptotic Events by Bid


Thursday, February 05 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Thursday, February 05 | 11:00AM - 1:00PM
Poster Setup
Room: Grays Peak


Thursday, February 05 | 1:00PM - 10:00PM
Poster Viewing
Room: Grays Peak


Thursday, February 05 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Longs Peak Foyer


Thursday, February 05 | 5:00PM - 7:00PM
Tissue-Specific Apoptotic Regulation
Room: Longs Peak

Speaker 1 of 4
Christine J. Watson, University of Cambridge, UK
Molecular Pathways Controlling Apoptosis in Mammary Gland Involution

Thursday, February 05 | 5:00PM - 7:00PM
Tissue-Specific Apoptotic Regulation
Room: Longs Peak

Speaker 2 of 4
* Scott W. Lowe, Memorial Sloan Kettering Cancer Center, USA
Apoptosis Links Cancer Genetics and Cancer Therapy

Thursday, February 05 | 5:00PM - 7:00PM
Tissue-Specific Apoptotic Regulation
Room: Longs Peak

Speaker 3 of 4
Malia B. Knezek, University of North Carolina at Chapel Hill, USA
Short Talk: Post-Cytochrome c Regulation of Apoptosis: Similarities between Neurons and Cardiomyoctyes

Thursday, February 05 | 5:00PM - 7:00PM
Tissue-Specific Apoptotic Regulation
Room: Longs Peak

Speaker 4 of 4
David Wallach, Weizmann Institute of Science, Israel
Exploring the in vivo Functions of Caspase-8 by Its Conditional Knockout in Mouse

Thursday, February 05 | 5:00PM - 7:00PM
Bcl-2 Family Proteins
This session is from Structural Biology of Apoptosi
Room: Quandry Peak

Speaker 1 of 4
Joseph T. Opferman, St. Jude Children's Research Hospital, USA
Gateways to Apoptosis


Thursday, February 05 | 5:00PM - 7:00PM
Bcl-2 Family Proteins
This session is from Structural Biology of Apoptosi
Room: Quandry Peak

Speaker 2 of 4
Nico Tjandra, National Institutes of Health, USA
Bax and Mitochondrial Fission


Thursday, February 05 | 5:00PM - 7:00PM
Bcl-2 Family Proteins
This session is from Structural Biology of Apoptosi
Room: Quandry Peak

Speaker 3 of 4
* Craig B. Thompson, Memorial Sloan Kettering Cancer Center, USA
Growth Factor Withdrawl Induced Cell Death: Apoptosis of Necrosis


Thursday, February 05 | 5:00PM - 7:00PM
Bcl-2 Family Proteins
This session is from Structural Biology of Apoptosi
Room: Quandry Peak

Speaker 4 of 4
David Ching Huang, Walter and Eliza Hall Institute of Medical Research, Australia
Short Talk: Interactions between Pro-Apoptotic BH3-Only Proteins and their Pro-Survival Bcl-2-Like Targets


Thursday, February 05 | 7:00PM - 8:00PM
Social Hour
Room: Longs Peak Foyer


Thursday, February 05 | 7:30PM - 10:00PM
Poster Session 2
Room: Grays Peak


Friday, February 06 | 7:00AM - 8:00AM
Breakfast
Room: Torreys/Grays


Friday, February 06 | 8:00AM - 11:00AM
Plants and Other Distant Relatives
Room: Longs Peak

Speaker 1 of 5
* Pierre Golstein, Centre d'Immunologie de Marseille-Luminy, France
Developmental Cell Death in Dictyostelium

Friday, February 06 | 8:00AM - 11:00AM
Plants and Other Distant Relatives
Room: Longs Peak

Speaker 2 of 5
Hanna Engelberg-Kulka, Hebrew University of Jerusalem, Israel
Programmed Cell Death in Bacteria

Friday, February 06 | 8:00AM - 11:00AM
Plants and Other Distant Relatives
Room: Longs Peak

Speaker 3 of 5
John Mundy, University of Copenhagen, Denmark
Arabidopsis Accelerated Cell Death 11 (Acd11): A Link between Sphingolipids and PCD

Friday, February 06 | 8:00AM - 11:00AM
Plants and Other Distant Relatives
Room: Longs Peak

Speaker 4 of 5
Luis Covarrubias, Independent National University of Mexico, Mexico
Short Talk: Growth Factor Interactions in the Activation of Interdigital Cell Death

Friday, February 06 | 8:00AM - 11:00AM
Plants and Other Distant Relatives
Room: Longs Peak

Speaker 5 of 5
Yohannes Tesfaigzi, Lovelace Respiratory Research Institute, USA
Short Talk: Regulation of Airway Epithelial Cell Homeostasis

Friday, February 06 | 8:00AM - 11:00AM
Mitochondria in Apoptosis: Therapeutic Potentials
This session is from Structural Biology of Apoptosi
Room: Quandry Peak

Speaker 1 of 5
* Stephen W. Fesik, Vanderbilt University School of Medicine, USA
Exploring the Therapeutic Potential of IAP Inhibitors


Friday, February 06 | 8:00AM - 11:00AM
Mitochondria in Apoptosis: Therapeutic Potentials
This session is from Structural Biology of Apoptosi
Room: Quandry Peak

Speaker 2 of 5
Ziwei Huang, Sanford-Burnham Medical Research Institute, USA
De Novo Design of Inhibitors of the Bcl-2 Family Proteins


Friday, February 06 | 8:00AM - 11:00AM
Mitochondria in Apoptosis: Therapeutic Potentials
This session is from Structural Biology of Apoptosi
Room: Quandry Peak

Speaker 3 of 5
Jeanne A. Hardy, University of Massachusetts Amherst, USA
Discovery of an Orphan Allosteric Site in Caspase by Tethering


Friday, February 06 | 8:00AM - 11:00AM
Mitochondria in Apoptosis: Therapeutic Potentials
This session is from Structural Biology of Apoptosi
Room: Quandry Peak

Speaker 4 of 5
Leigh Zawel, Cullinan Oncology, USA
Development of Smac Mimetics as Anti-Cancer Therapeutics


Friday, February 06 | 8:00AM - 11:00AM
Mitochondria in Apoptosis: Therapeutic Potentials
This session is from Structural Biology of Apoptosi
Room: Quandry Peak

Speaker 5 of 5
Martin Holcik, Children's Hospital-Eastern Ontario Research Institute, Canada
Short Talk: IRES-Mediated Translational Activation of Apaf1 is Essential for UV-Induced Cell Death


Friday, February 06 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Friday, February 06 | 11:00AM - 1:00PM
Poster Setup
Room: Grays Peak


Friday, February 06 | 1:00PM - 10:00PM
Poster Viewing
Room: Grays Peak


Friday, February 06 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Longs Peak Foyer


Friday, February 06 | 5:00PM - 7:00PM
The Last Word - Phagocytosis and Apoptotic Cell Degradation
Room: Longs Peak

Speaker 1 of 4
* Nathalie C. Franc, University College London, UK
Phagocytosis of Apoptotic Cells in Drosophila

Friday, February 06 | 5:00PM - 7:00PM
The Last Word - Phagocytosis and Apoptotic Cell Degradation
Room: Longs Peak

Speaker 2 of 4
Richard A. Lang, Cincinnati Children's Hospital Medical Center, USA
Macrophage-Mediated Programmed Capillary Regression is Dependent upon Wnt Signaling

Friday, February 06 | 5:00PM - 7:00PM
The Last Word - Phagocytosis and Apoptotic Cell Degradation
Room: Longs Peak

Speaker 3 of 4
Katharina Germaine D'Herde, Ghent University, Belgium
Short Talk: Internalization Mechanisms of Macrophages for Clearance of Apoptotic and Necrotic L929 Cells Studied in a Coculture System by TEM

Friday, February 06 | 5:00PM - 7:00PM
The Last Word - Phagocytosis and Apoptotic Cell Degradation
Room: Longs Peak

Speaker 4 of 4
Jens Böse, German Research Center for Biotechnology (GBF), Germany
Short Talk: Essential Functions of Ptdsr during Embryogenesis, Distinct from Apoptotic Cell Removal

Friday, February 06 | 5:00PM - 7:00PM
Late Breaking Developments
This session is from Structural Biology of Apoptosi
Room: Quandry Peak

Speaker 1 of 4
Ding Xue, University of Colorado, USA
An Important Role for Mitochondria in the Programmed Cell Death of C. elegans


Friday, February 06 | 5:00PM - 7:00PM
Late Breaking Developments
This session is from Structural Biology of Apoptosi
Room: Quandry Peak

Speaker 2 of 4
Valina L. Dawson, Johns Hopkins University School of Medicine, USA
Mechanisms of PARP-1 Dependent AIF-Mediated Cell Death


Friday, February 06 | 5:00PM - 7:00PM
Late Breaking Developments
This session is from Structural Biology of Apoptosi
Room: Quandry Peak

Speaker 3 of 4
* Jürg Tschopp, University of Lausanne, Switzerland
Activation of Initiator Caspases


Friday, February 06 | 5:00PM - 7:00PM
Late Breaking Developments
This session is from Structural Biology of Apoptosi
Room: Quandry Peak

Speaker 4 of 4
George L. McLendon, Duke University, USA
Short Talk: Novel Targets for Apoptosis


Friday, February 06 | 7:00PM - 8:00PM
Social Hour
Room: Longs Peak Foyer


Friday, February 06 | 7:30PM - 10:00PM
Poster Session 3
Room: Grays Peak


Saturday, February 07 | 7:00AM - 8:00AM
Breakfast
Room: Torreys/Grays


Saturday, February 07 | 8:00AM - 11:00AM
Regulators of Apoptosis (Joint)
Room: Longs/Quandry

Speaker 1 of 4
Gabriel Nuñez, University of Michigan, USA
The NOD Family of Proteins: Role in Apoptosis and Inflammation

Saturday, February 07 | 8:00AM - 11:00AM
Regulators of Apoptosis (Joint)
Room: Longs/Quandry

Speaker 2 of 4
J. Marie Hardwick, Johns Hopkins University Schools of Public Health and Medicine, USA
Regulation of Mitochondrial Morphology: Structure and Function

Saturday, February 07 | 8:00AM - 11:00AM
Regulators of Apoptosis (Joint)
Room: Longs/Quandry

Speaker 3 of 4
* Hermann Steller, Rockefeller University, USA
Integration of Apoptotic Signaling Pathways

Saturday, February 07 | 8:00AM - 11:00AM
Regulators of Apoptosis (Joint)
Room: Longs/Quandry

Speaker 4 of 4
Richard N. Kitsis, Albert Einstein College of Medicine, USA
Inhibition of Both Extrinsic and Intrinsic Death Pathways by Novel Death-Fold Interactions

Saturday, February 07 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Saturday, February 07 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Longs Peak Foyer


Saturday, February 07 | 5:00PM - 7:00PM
Too Hot to Print - Exciting New Developments (Joint)
Room: Longs/Quandry

Speaker 1 of 4
Gerry Melino, University of Rome ‘Tor Vergata’, Italy
Short Talk: Control of p73 Degradation in DNA Damage

Saturday, February 07 | 5:00PM - 7:00PM
Too Hot to Print - Exciting New Developments (Joint)
Room: Longs/Quandry

Speaker 2 of 4
Maya Saleh, McGill University, Canada
Short Talk: Association of a Human Caspase-12 Polymorphism with Endotoxin Hypo-Responsiveness and Severe Sepsis but not Alzheimer's Disease

Saturday, February 07 | 5:00PM - 7:00PM
Too Hot to Print - Exciting New Developments (Joint)
Room: Longs/Quandry

Speaker 3 of 4
* Douglas R. Green, St. Jude Children's Research Hospital, USA
The Caspase-Mitochondrial Axis: 25 Minutes in the Death of a Cell

Saturday, February 07 | 5:00PM - 7:00PM
Too Hot to Print - Exciting New Developments (Joint)
Room: Longs/Quandry

Speaker 4 of 4
Tak W. Mak, Campbell Family Institute for Breast Cancer, Canada
Apoptotic Gene Function in Immune System Development

Saturday, February 07 | 7:00PM - 8:00PM
Social Hour
Room: Longs Peak Foyer


Saturday, February 07 | 8:00PM - 11:00PM
Entertainment
Room: Torreys/Grays


Saturday, February 07 | 8:00PM - 11:00PM
Cash Bar
Room: Torreys/Grays


Sunday, February 08 | 10:26AM - 10:26AM
Departure


*Session Chair.