Web Desc
Nuclear Receptors: Steroid Sisters
joint with Nuclear Receptors: Orphan Brothers
Organizer(s): Donald P. McDonnell and Adriana Maggi
Date: February 28 - March 04, 2004
Location: Keystone Resort, Keystone, CO, USA
Sponsored in part by the Director's Sponsor Fund
Summary of Meeting:
Upon completion of this conference, participants should be able to: - Have a general knowledge of the importance of nuclear receptors in health and disease, and as potential targets for drug discovery. - Compare the difference and similarity in the biochemical mechanisms of action used by the classic steroid/endocrine receptors and the orphan receptors. - Identify novel ligands and physiologic pathways for the orphan nuclear receptors. Characterize the latest structural/functional properties of receptors from the 3-D structures of their various domains complexed with ligands, cofactors, and DNA. - Have an understanding of the latest biological tools (e.g., animal models, novel ligands, structural information) and technologies (e.g., genomics, proteomics, ligand screening) available for nuclear receptor research. - Promote a productive interaction between academic labs and industry. - Bring together and foster the interaction between the field's leading experts and younger scientists and trainees, with a particular emphasis on the inclusion of under represented groups.
Discounted Abstract Deadline: October 28 2003
Discounted Registration Deadline: December 29 2003
We gratefully acknowledge additional support for this conference from:

X-Ceptor Therapeutics, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA106219-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Saturday, February 28 | 3:00PM - 7:00PM
Registration
Room: Longs Peak Foyer


Saturday, February 28 | 6:15PM - 7:15PM
Refreshments
Room: Longs Peak Foyer


Saturday, February 28 | 7:15PM - 7:30PM
Orientation
Room: Red Cloud/Shavano/Torreys


Saturday, February 28 | 7:30PM - 8:30PM
Keynote Address (Joint)
Room: Red Cloud/Shavano/Torreys

Speaker 2 of 2
Steven L. McKnight, University of Texas Southwestern Medical Center, USA
Reciprocal Coupling of Metabolism and Circadian Rhythm

Saturday, February 28 | 7:30PM - 8:30PM
Keynote Address (Joint)
Room: Red Cloud/Shavano/Torreys

Speaker 1 of 2
* David J. Mangelsdorf, University of Texas Southwestern Medical Center, USA

Sunday, February 29 | 7:00AM - 8:00AM
Breakfast
Room: Grays/Longs/Quandary


Sunday, February 29 | 8:00AM - 11:00AM
Neuroendocrine Regulators
This session is from Nuclear Receptors: Orphan
Room: Red Cloud

Speaker 6 of 6
Timo Kanzleiter, German Institute of Human Nutrition, Germany
Short Talk: An Orphan in the Cold: A Putative Function of Nur77 for Adaptive Thermogenesis in Brown Adipose Tissue


Sunday, February 29 | 8:00AM - 11:00AM
Neuroendocrine Regulators
This session is from Nuclear Receptors: Orphan
Room: Red Cloud

Speaker 5 of 6
Ueli Schibler, University of Geneva, Switzerland
Nuclear Receptors and Circadian Rhythms


Sunday, February 29 | 8:00AM - 11:00AM
Neuroendocrine Regulators
This session is from Nuclear Receptors: Orphan
Room: Red Cloud

Speaker 4 of 6
Orla M. Conneely, Baylor College of Medicine, USA
Essential and Redundant Roles of Nor-1 and Nur77 in Regulation of Myelopoiesis


Sunday, February 29 | 8:00AM - 11:00AM
Neuroendocrine Regulators
This session is from Nuclear Receptors: Orphan
Room: Red Cloud

Speaker 3 of 6
Thomas Perlmann, Karolinska Institutet, Ludwig Institute for Cancer Research, Sweden
Ligand-Independent Nuclear Receptors in the CNS


Sunday, February 29 | 8:00AM - 11:00AM
Neuroendocrine Regulators
This session is from Nuclear Receptors: Orphan
Room: Red Cloud

Speaker 2 of 6
Holly A. Ingraham, University of California, San Francisco, USA
Orphan Nuclear Receptors of Subfamily V – Gene Dosage Effects and Ligand Independent Modulation


Sunday, February 29 | 8:00AM - 11:00AM
Neuroendocrine Regulators
This session is from Nuclear Receptors: Orphan
Room: Red Cloud

Speaker 1 of 6
* Johan Auwerx, École Polytechnique Fédérale de Lausanne, Switzerland


Sunday, February 29 | 8:00AM - 11:00AM
General Steroid Hormone Action
Room: Shavano/Torreys

Speaker 6 of 6
Debu Chakravarti, Northwestern University, Feinberg School of Medicine, USA
Short Talk: Translating the Histone Code of Transcription

Sunday, February 29 | 8:00AM - 11:00AM
General Steroid Hormone Action
Room: Shavano/Torreys

Speaker 5 of 6
Olli A. Jänne, University of Helsinki, Finland
Sumoylation in Androgen Receptor Signaling

Sunday, February 29 | 8:00AM - 11:00AM
General Steroid Hormone Action
Room: Shavano/Torreys

Speaker 4 of 6
Shigeaki Kato, University of Tokyo, Japan
Co-Regulator and Chromatin Remodeling Complexes for Nuclear Receptors

Sunday, February 29 | 8:00AM - 11:00AM
General Steroid Hormone Action
Room: Shavano/Torreys

Speaker 3 of 6
Donald P. McDonnell, Duke University School of Medicine, USA
The Efficacy of Agonist Activated Nuclear Receptors is Dramatically Enhanced by Exposure to Short Chain Fatty Acids in vitro and in vivo

Sunday, February 29 | 8:00AM - 11:00AM
General Steroid Hormone Action
Room: Shavano/Torreys

Speaker 2 of 6
John W. Funder, Prince Henry's Institute of Medical Research, Australia
Aldosterone, Cardiovascular Damage: The New Biology of Mineralocorticoid Receptors

Sunday, February 29 | 8:00AM - 11:00AM
General Steroid Hormone Action
Room: Shavano/Torreys

Speaker 1 of 6
* Adriana Maggi, University of Milan, Italy

Sunday, February 29 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Sunday, February 29 | 11:00AM - 1:00PM
Poster Setup
Room: Grays/Longs/Quandary


Sunday, February 29 | 1:00PM - 10:00PM
Poster Viewing
Room: Grays/Longs/Quandary


Sunday, February 29 | 3:00PM - 4:00PM
Hot Topics 1
Room: Shavano/Torreys

Speaker 3 of 5
Wilson H. Miller, Jr., McGill University, Canada
Expression of SMRTbeta Promotes Ligand-Induced Activation of Mutated and Wild-Type Retinoid Receptors

Sunday, February 29 | 3:00PM - 4:00PM
Hot Topics 1
Room: Shavano/Torreys

Speaker 2 of 5
István Szatmári, University of Debrecen, Hungary
Retinoids Affect Differentiation and Function of Human Monocyte-Derived Dendritic Cells

Sunday, February 29 | 3:00PM - 4:00PM
Hot Topics 1
Room: Shavano/Torreys

Speaker 1 of 5
* Michael J. Garabedian, New York University School of Medicine, USA

Sunday, February 29 | 3:00PM - 4:00PM
Hot Topics 1
Room: Shavano/Torreys

Speaker 4 of 5
Martin L. Privalsky, University of California, Davis, USA
Isotype-Specificity in the Nuclear Receptor/Corepressor Interaction and in Transcriptional Repression

Sunday, February 29 | 3:00PM - 4:00PM
Hot Topics 1
Room: Shavano/Torreys

Speaker 5 of 5
Rob Jam Michalides, Netherlands Cancer Institute, Netherlands
Tamoxifen Resistance by a Conformational Arrest of the Estrogen Receptor-alpha after PKA Activation in Breast Cancer: Mechanism of Anti-Estrogen Resistance in Breast Cancer

Sunday, February 29 | 3:00PM - 4:00PM
Hot Topics 1
This session is from Nuclear Receptors: Orphan
Room: Red Cloud

Speaker 1 of 5
* Holly A. Ingraham, University of California, San Francisco, USA


Sunday, February 29 | 3:00PM - 4:00PM
Hot Topics 1
This session is from Nuclear Receptors: Orphan
Room: Red Cloud

Speaker 2 of 5
Kim Jongsook Kemper, University of Illinois at Urbana-Champaign, USA
A Corepressor mSin3A-Swi/Snf Human Chromatin Remodeling Complex Mediates Repressor SHP Action in Cholesterol/Bile Acid Metabolism


Sunday, February 29 | 3:00PM - 4:00PM
Hot Topics 1
This session is from Nuclear Receptors: Orphan
Room: Red Cloud

Speaker 3 of 5
Janet M. Allen, University College Dublin, Ireland
Beyond the 48: Identification of Novel Nuclear Receptors


Sunday, February 29 | 3:00PM - 4:00PM
Hot Topics 1
This session is from Nuclear Receptors: Orphan
Room: Red Cloud

Speaker 4 of 5
Yuriy Shostak, Acropolis, USA
In vitro Genomic Selection: From the C. elegans Genome, to DAF-12 Binding Sites and Response Elements, to Target Genes


Sunday, February 29 | 3:00PM - 4:00PM
Hot Topics 1
This session is from Nuclear Receptors: Orphan
Room: Red Cloud

Speaker 5 of 5
Michael R. Downes, The Salk Institute, USA
A Chemical, Genetic and Structural Analysis of the Nuclear Bile Acid Receptor FXR


Sunday, February 29 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Longs Peak Foyer


Sunday, February 29 | 5:00PM - 7:00PM
Transcription and Chromatin (Joint)
Room: Red Cloud/Shavano/Torreys

Speaker 1 of 4
* Ronald M. Evans, HHMI/The Salk Institute, USA

Sunday, February 29 | 5:00PM - 7:00PM
Transcription and Chromatin (Joint)
Room: Red Cloud/Shavano/Torreys

Speaker 2 of 4
Beverly M. Emerson, CEDAR, OHSU Knight Cancer Institute, USA
Specificity of Gene Regulation through Chromatin

Sunday, February 29 | 5:00PM - 7:00PM
Transcription and Chromatin (Joint)
Room: Red Cloud/Shavano/Torreys

Speaker 3 of 4
Gordon L. Hager, NCI, National Institutes of Health, USA
Dynamic Interaction of Steroid Receptors with Gene Targets

Sunday, February 29 | 5:00PM - 7:00PM
Transcription and Chromatin (Joint)
Room: Red Cloud/Shavano/Torreys

Speaker 4 of 4
Robert G. Roeder, Rockefeller University, USA
Integrated Functions of Diverse Coactivators in Transcriptional Activation by Nuclear Receptors.

Sunday, February 29 | 7:00PM - 8:00PM
Social Hour
Room: Grays/Longs/Quandary


Sunday, February 29 | 7:30PM - 10:00PM
Poster Session 1
Room: Grays/Longs/Quandary


Monday, March 01 | 7:00AM - 8:00AM
Breakfast
Room: Grays/Longs/Quandary


Monday, March 01 | 8:00AM - 11:00AM
Progesterone and Estrogen Action
Room: Shavano/Torreys

Speaker 1 of 5
* Dean P. Edwards, Baylor College of Medicine, USA
Extranuclear Signaling Mechanisms and Functions of the Progesterone Receptor

Monday, March 01 | 8:00AM - 11:00AM
Progesterone and Estrogen Action
Room: Shavano/Torreys

Speaker 2 of 5
Adriana Maggi, University of Milan, Italy
Mechanisms of Estrogen Receptor Activation in vivo

Monday, March 01 | 8:00AM - 11:00AM
Progesterone and Estrogen Action
Room: Shavano/Torreys

Speaker 3 of 5
Benita S. Katzenellenbogen, University of Illinois, USA
Estrogen Receptors: Structure-Activity Relationships and Regulation of Gene Expression

Monday, March 01 | 8:00AM - 11:00AM
Progesterone and Estrogen Action
Room: Shavano/Torreys

Speaker 4 of 5
Phyllis M. Wise, University of California, Davis, USA
Novel Actions of Estrogens: Protective or Risk Factors in Brain Function

Monday, March 01 | 8:00AM - 11:00AM
Progesterone and Estrogen Action
Room: Shavano/Torreys

Speaker 5 of 5
Evan Simpson, Prince Henry's Institute, Australia
Short Talk: LRH-1 and SHP Roles in Estrogen Regulation and the Metabolic Syndrome

Monday, March 01 | 8:00AM - 11:00AM
Enterohepatic Metabolism
This session is from Nuclear Receptors: Orphan
Room: Red Cloud

Speaker 1 of 5
David D. Moore, Baylor College of Medicine, USA
Mechanisms of Action of Nongenotoxic CARcinogens


Monday, March 01 | 8:00AM - 11:00AM
Enterohepatic Metabolism
This session is from Nuclear Receptors: Orphan
Room: Red Cloud

Speaker 2 of 5
Steven A. Kliewer, University of Texas Southwestern Medical Center, USA
Regulatory Actions of Enterohepatic Nuclear Receptors


Monday, March 01 | 8:00AM - 11:00AM
Enterohepatic Metabolism
This session is from Nuclear Receptors: Orphan
Room: Red Cloud

Speaker 3 of 5
Brandee Wagner, Metacrine, USA
Metabolic Regulation by Orphan Nuclear Receptors


Monday, March 01 | 8:00AM - 11:00AM
Enterohepatic Metabolism
This session is from Nuclear Receptors: Orphan
Room: Red Cloud

Speaker 4 of 5
Johan Auwerx, École Polytechnique Fédérale de Lausanne, Switzerland
Entero Hepatic Receptors and Homeostatic Control


Monday, March 01 | 8:00AM - 11:00AM
Enterohepatic Metabolism
This session is from Nuclear Receptors: Orphan
Room: Red Cloud

Speaker 5 of 5
* Frank J. Gonzalez, National Institutes of Health, USA
Short Talk: Exploring PPAR Function


Monday, March 01 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Monday, March 01 | 11:00AM - 1:00PM
Poster Setup
Room: Grays/Longs/Quandary


Monday, March 01 | 1:00PM - 10:00PM
Poster Viewing
Room: Grays/Longs/Quandary


Monday, March 01 | 3:00PM - 4:00PM
Hot Topics 2
Room: Shavano/Torreys

Speaker 1 of 4
* Carol A. Lange, University of Minnesota, USA
Progestin and Mitogen Activated Protein Kinase (MAPK) Dependent Changes in Cell Cycle Regulation in Human Breast Cancer Cells

Monday, March 01 | 3:00PM - 4:00PM
Hot Topics 2
Room: Shavano/Torreys

Speaker 2 of 4
Cem Elbi, Merrimack Pharmaceuticals, USA
Molecular Chaperones Function as Steroid Receptor Nuclear Mobility Factors

Monday, March 01 | 3:00PM - 4:00PM
Hot Topics 2
Room: Shavano/Torreys

Speaker 3 of 4
Raymond Blind, Vanderbilt University School of Medicine, USA
Regulation of Glucocorticoid Receptor-Mediated Transcriptional activation: The Role of Receptor Phosphorylation and Cofactor Recruitment

Monday, March 01 | 3:00PM - 4:00PM
Hot Topics 2
Room: Shavano/Torreys

Speaker 4 of 4
Dennis H. Dowhan, Baylor College of Medicine, USA
Regulation of Steroid Hormone Receptor Mediated Alternative Splicing by U2AF-Related Proteins CAPER & CAPERb

Monday, March 01 | 3:00PM - 4:00PM
Hot Topics 2
This session is from Nuclear Receptors: Orphan
Room: Red Cloud

Speaker 1 of 4
Toshiya Tanaka, University of Tokyo, Japan
Activation of Peroxisome Proliferator-Activated Receptor delta Induces Fatty Acid beta-oxidation in Skeletal Muscle and Attenuates Diet-Induced Obesity and Insulin Resistance


Monday, March 01 | 3:00PM - 4:00PM
Hot Topics 2
This session is from Nuclear Receptors: Orphan
Room: Red Cloud

Speaker 2 of 4
Bernard R. Pipy, France
Role of PPARgamma in Induction of Macrophage Mannose Receptor Gene Expression: Implication in the Control of Gastrointestinal Candidosis in Normal and Immunodeficient RAG-2-/- Mice


Monday, March 01 | 3:00PM - 4:00PM
Hot Topics 2
This session is from Nuclear Receptors: Orphan
Room: Red Cloud

Speaker 3 of 4
* George E.O. Muscat, University of Queensland, Australia
RORalpha (NR1F1) Regulates the Expression of Genes Involved in Lipid Catabolism, Cholesterol and Energy Homeostasis in Skeletal Muscle Cells


Monday, March 01 | 3:00PM - 4:00PM
Hot Topics 2
This session is from Nuclear Receptors: Orphan
Room: Red Cloud

Speaker 4 of 4
Wen Xie, University of Pittsburgh, USA
A Novel CAR-Mediated and CYP3A-Independent Pathway of Bile Acid Detoxification


Monday, March 01 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Longs Peak Foyer


Monday, March 01 | 5:00PM - 7:00PM
Nuclear Receptor Coregulators (Joint)
Room: Red Cloud/Shavano/Torreys

Speaker 1 of 4
* Bert W. O'Malley, Baylor College of Medicine, USA

Monday, March 01 | 5:00PM - 7:00PM
Nuclear Receptor Coregulators (Joint)
Room: Red Cloud/Shavano/Torreys

Speaker 2 of 4
Keith R. Yamamoto, University of California, San Francisco, USA
Hormones and Response Elements: Two Receptor Ligands that Together Specify Functional Surfaces and Trascriptional Regulatory Networks

Monday, March 01 | 5:00PM - 7:00PM
Nuclear Receptor Coregulators (Joint)
Room: Red Cloud/Shavano/Torreys

Speaker 3 of 4
Christopher K. Glass, University of California, San Diego, USA
Nuclear Receptors and Inflammation

Monday, March 01 | 5:00PM - 7:00PM
Nuclear Receptor Coregulators (Joint)
Room: Red Cloud/Shavano/Torreys

Speaker 4 of 4
Bruce M. Spiegelman, Harvard Medical School, USA
OXPHOS Pathway Dysregulated in Human Diabetes is Controlled by PGC-1 Coactivation

Monday, March 01 | 7:00PM - 8:00PM
Social Hour
Room: Grays/Longs/Quandary


Monday, March 01 | 7:30PM - 10:00PM
Poster Session 2
Room: Grays/Longs/Quandary


Tuesday, March 02 | 7:00AM - 8:00AM
Breakfast
Room: Grays/Longs/Quandary


Tuesday, March 02 | 8:00AM - 11:00AM
Vitamin D and T3 Receptors
Room: Shavano/Torreys

Speaker 1 of 5
Jacques Samarut, Centre National de la Recherche Scientifique, France
Roles of Thyroid Hormone Receptor Isoforms in Mouse Development

Tuesday, March 02 | 8:00AM - 11:00AM
Vitamin D and T3 Receptors
Room: Shavano/Torreys

Speaker 2 of 5
* Leonard P. Freedman, Global Biological Standards Institute, USA
Nuclear Receptor Coactivators: It's Hip to be DRIP

Tuesday, March 02 | 8:00AM - 11:00AM
Vitamin D and T3 Receptors
Room: Shavano/Torreys

Speaker 3 of 5
Catherine C. Thompson, Pfizer, USA
Multiple Roles of the Corepressor Hairless in Nuclear Receptor Signaling

Tuesday, March 02 | 8:00AM - 11:00AM
Vitamin D and T3 Receptors
Room: Shavano/Torreys

Speaker 4 of 5
Judah S. Denburg, McMaster University, Canada
Selective Thyroid Hormone Analogs

Tuesday, March 02 | 8:00AM - 11:00AM
Vitamin D and T3 Receptors
Room: Shavano/Torreys

Speaker 5 of 5
Myles Brown, Dana-Farber Cancer Institute, USA
Short Talk: Coactivator as Oncogene

Tuesday, March 02 | 8:00AM - 11:00AM
Developmental Regulators
This session is from Nuclear Receptors: Orphan
Room: Red Cloud

Speaker 1 of 5
Carl S. Thummel, University of Utah School of Medicine, USA
Molecular Mechanisms of Hormone Signaling and Nuclear Receptor Function in Drosophila


Tuesday, March 02 | 8:00AM - 11:00AM
Developmental Regulators
This session is from Nuclear Receptors: Orphan
Room: Red Cloud

Speaker 2 of 5
Ann E. Sluder, Cambria Biosciences LLC, USA
Nematode Nuclear Receptors: Conservation, Variation and Function


Tuesday, March 02 | 8:00AM - 11:00AM
Developmental Regulators
This session is from Nuclear Receptors: Orphan
Room: Red Cloud

Speaker 3 of 5
Vincent Giguère, McGill University, Canada
Molecular Mechanisms and Functional Genomics of ERR/PGC-1 Interaction in Metabolic Control


Tuesday, March 02 | 8:00AM - 11:00AM
Developmental Regulators
This session is from Nuclear Receptors: Orphan
Room: Red Cloud

Speaker 4 of 5
Carole R. Mendelson, University of Texas Southwestern Medical Center, USA
Regulation of Mammalian Parturition by Nuclear Receptors and Coactivators


Tuesday, March 02 | 8:00AM - 11:00AM
Developmental Regulators
This session is from Nuclear Receptors: Orphan
Room: Red Cloud

Speaker 5 of 5
* Austin J. Cooney, Baylor College of Medicine, USA
Short Talk: Reciprocal Regulation of Oct4 Expression by the Orphan Receptors LRH-1 and GCNF


Tuesday, March 02 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Tuesday, March 02 | 11:00AM - 1:00PM
Poster Setup
Room: Grays/Longs/Quandary


Tuesday, March 02 | 1:00PM - 10:00PM
Poster Viewing
Room: Grays/Longs/Quandary


Tuesday, March 02 | 3:00PM - 4:00PM
Hot Topics 3
Room: Shavano/Torreys

Speaker 1 of 5
* Karen E. Knudsen, Thomas Jefferson University, Kimmel Cancer Center, USA

Tuesday, March 02 | 3:00PM - 4:00PM
Hot Topics 3
Room: Shavano/Torreys

Speaker 2 of 5
Kevin Link, Cincinnati Children's Hospital Medical Center, USA
SWI/SNF is Required for Co-Activator Stimulated Androgen Receptor Activation

Tuesday, March 02 | 3:00PM - 4:00PM
Hot Topics 3
Room: Shavano/Torreys

Speaker 3 of 5
Catherine F. Teyssier, INSERM EMI 0229, France
Regulation of PGC-1 Coactivator Activity by Arginine Methylation

Tuesday, March 02 | 3:00PM - 4:00PM
Hot Topics 3
Room: Shavano/Torreys

Speaker 4 of 5
Paul M. Yen, Johns Hopkins University, USA
Cyclical Recruitment of TFIIH Subunits and other Co-Activators to Thyroid Hormone Response Elements (TREs): Evidence for 'Signature' Coactivator Profiles in Target Gene Regulation

Tuesday, March 02 | 3:00PM - 4:00PM
Hot Topics 3
Room: Shavano/Torreys

Speaker 5 of 5
Michael A. Mancini, Baylor College of Medicine, USA
Transcription Factor Dynamics on Integrated Prolactin Promoter-Enhancer Arrays

Tuesday, March 02 | 3:00PM - 4:00PM
Hot Topics 3
This session is from Nuclear Receptors: Orphan
Room: Red Cloud

Speaker 1 of 5
Lena Jendeberg, Biovitrum, Sweden
Structural Insights into the Heterodimeric Complex of LXRa and RXRb Ligand-Binding Domains in a Fully Agonistic Conformation


Tuesday, March 02 | 3:00PM - 4:00PM
Hot Topics 3
This session is from Nuclear Receptors: Orphan
Room: Red Cloud

Speaker 2 of 5
Andrew I. Shulman, University of Texas Southwestern Medical Center, USA
Molecular Basis of Allosteric Ligand Activation in RXR Heterodimers


Tuesday, March 02 | 3:00PM - 4:00PM
Hot Topics 3
This session is from Nuclear Receptors: Orphan
Room: Red Cloud

Speaker 3 of 5
* Frances M. Sladek, University of California, Riverside, USA
Comparison of HNF4 Binding Sites in the Human and Mouse Genomes


Tuesday, March 02 | 3:00PM - 4:00PM
Hot Topics 3
This session is from Nuclear Receptors: Orphan
Room: Red Cloud

Speaker 4 of 5
Souphatta Sasorith, Institut de Genetique et de Biologie Moleculaire et Cellulaire(IGBMC), France
3D Nuclear Receptors Thematic Database


Tuesday, March 02 | 3:00PM - 4:00PM
Hot Topics 3
This session is from Nuclear Receptors: Orphan
Room: Red Cloud

Speaker 5 of 5
Yanhong Shi, Beckman Research Institute of City of Hope, USA
The Expression and Function of Orphan Nuclear Receptor TLX in Adult Neural Stem Cells


Tuesday, March 02 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Longs Peak Foyer


Tuesday, March 02 | 5:00PM - 7:00PM
3-D Structure (Joint)
Room: Red Cloud/Shavano/Torreys

Speaker 1 of 5
* Donald P. McDonnell, Duke University School of Medicine, USA

Tuesday, March 02 | 5:00PM - 7:00PM
3-D Structure (Joint)
Room: Red Cloud/Shavano/Torreys

Speaker 2 of 5
Timothy M. Willson, GlaxoSmithKline, USA
Are All Orphan Nuclear Receptors Good Drug Targets?

Tuesday, March 02 | 5:00PM - 7:00PM
3-D Structure (Joint)
Room: Red Cloud/Shavano/Torreys

Speaker 3 of 5
Jean-Paul Renaud, NovAliX, France
Orphan Nuclear Receptor Characterization through Structural Studies

Tuesday, March 02 | 5:00PM - 7:00PM
3-D Structure (Joint)
Room: Red Cloud/Shavano/Torreys

Speaker 4 of 5
Geoffrey L. Greene, University of Chicago, USA
Short Talk: ERalpha/ERbeta Ligand Discrimination and Allosteric Communication between Ligand, Receptor and Co-Regulators

Tuesday, March 02 | 5:00PM - 7:00PM
3-D Structure (Joint)
Room: Red Cloud/Shavano/Torreys

Speaker 5 of 5
Ronald N. Margolis, NIDDK, National Institutes of Health, USA
Short Talk: The Nuclear Receptor Signaling Atlas: Building a Comprehensive Atlas of Orphan and Nuclear Receptor Function

Tuesday, March 02 | 7:00PM - 8:00PM
Social Hour
Room: Grays/Longs/Quandary


Tuesday, March 02 | 7:30PM - 10:00PM
Poster Session 3
Room: Grays/Longs/Quandary


Wednesday, March 03 | 7:00AM - 8:00AM
Breakfast
Room: Grays/Longs/Quandary


Wednesday, March 03 | 8:00AM - 11:00AM
Steroid Receptors and Disease
Room: Shavano/Torreys

Speaker 1 of 5
Frank Gannon, QIMR Berghofer Medical Research Institute, Australia
Estrogen Receptor-a Directs Cyclical Epigenetic Processes on a Natural Promoter through the Ordered, Combinatorial Recruitment of Cofactors

Wednesday, March 03 | 8:00AM - 11:00AM
Steroid Receptors and Disease
Room: Shavano/Torreys

Speaker 2 of 5
J. Wesley Pike, University of Wisconsin-Madison, USA
Molecular Actions of Vitamin D and Its Analogs in Transcriptional Regulation

Wednesday, March 03 | 8:00AM - 11:00AM
Steroid Receptors and Disease
Room: Shavano/Torreys

Speaker 3 of 5
Kenneth S. Korach, NIEHS, National Institutes of Health, USA
Physiological Disruption Due to Loss of Functional Estrogen Receptors

Wednesday, March 03 | 8:00AM - 11:00AM
Steroid Receptors and Disease
Room: Shavano/Torreys

Speaker 4 of 5
Jan-Åke Gustafsson, University of Houston, USA
New Roles of Estrogen Receptor Beta

Wednesday, March 03 | 8:00AM - 11:00AM
Steroid Receptors and Disease
Room: Shavano/Torreys

Speaker 5 of 5
* Heather A. Harris, Wyeth Pharmaceuticals, USA
Short Talk: Selective Estrogen Receptor-Beta Agonists are Potent Anti-Inflammatory Agents

Wednesday, March 03 | 8:00AM - 11:00AM
Intermediary Metabolism
This session is from Nuclear Receptors: Orphan
Room: Red Cloud

Speaker 1 of 5
David J. Mangelsdorf, University of Texas Southwestern Medical Center, USA
Orphan Brother, Where Art Thou?


Wednesday, March 03 | 8:00AM - 11:00AM
Intermediary Metabolism
This session is from Nuclear Receptors: Orphan
Room: Red Cloud

Speaker 2 of 5
Daniel Metzger, Institut de Génétique et de Biologie Molécullaire et Cellulaire, Strasbourg, France
Functional Role of RXRs and PPARgamma in Adipocytes


Wednesday, March 03 | 8:00AM - 11:00AM
Intermediary Metabolism
This session is from Nuclear Receptors: Orphan
Room: Red Cloud

Speaker 3 of 5
Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA
Nuts and Bolts of Repression


Wednesday, March 03 | 8:00AM - 11:00AM
Intermediary Metabolism
This session is from Nuclear Receptors: Orphan
Room: Red Cloud

Speaker 4 of 5
Peter Tontonoz, University of California, Los Angeles, USA
Orphan Nuclear Receptors in Atherosclerosis


Wednesday, March 03 | 8:00AM - 11:00AM
Intermediary Metabolism
This session is from Nuclear Receptors: Orphan
Room: Red Cloud

Speaker 5 of 5
* Malcolm G. Parker, Imperial College London, UK
Short Talk: Role of RIP140 Corepressor in Adipose Biology


Wednesday, March 03 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Wednesday, March 03 | 3:30PM - 4:30PM
Hot Topics 4
Room: Shavano/Torreys

Speaker 1 of 5
* E. Brad Thompson, University of Texas Medical Branch, USA

Wednesday, March 03 | 3:30PM - 4:30PM
Hot Topics 4
Room: Shavano/Torreys

Speaker 2 of 5
Raj Kumar, Commonwealth Medical College, USA
Induced alpha-Helix Structure in the AF1 of the Steroid Receptors Upon Direct Binding to Cofactor Protein

Wednesday, March 03 | 3:30PM - 4:30PM
Hot Topics 4
Room: Shavano/Torreys

Speaker 3 of 5
Eugene Hur, University of California, San Francisco, USA
Accommodation and Discrimination of Hydrophobic Motifs in the Androgen Receptor

Wednesday, March 03 | 3:30PM - 4:30PM
Hot Topics 4
Room: Shavano/Torreys

Speaker 4 of 5
Fraydoon Rastinejad, University of Oxford, UK
Structural Basis for Bile Acid Binding and Activation of FXR

Wednesday, March 03 | 3:30PM - 4:30PM
Hot Topics 4
Room: Shavano/Torreys

Speaker 5 of 5
Timothy R. Geistlinger, Amyris, USA
Specific Proteomimetic Inhibitors of NR:SCR

Wednesday, March 03 | 3:30PM - 4:30PM
Hot Topics 4
This session is from Nuclear Receptors: Orphan
Room: Red Cloud

Speaker 1 of 4
* Bruce Blumberg, University of California, Irvine, USA
Vitamin K2 Regulation of Bone Homeostasis is Mediated by the Steroid and Xenobiotic Receptor, SXR


Wednesday, March 03 | 3:30PM - 4:30PM
Hot Topics 4
This session is from Nuclear Receptors: Orphan
Room: Red Cloud

Speaker 2 of 4
David Hervé Volle, Institut de Génétique et de Biologie Moléculaire et Cellulaire, France
Testicular Function in LXR-Deficient Mice


Wednesday, March 03 | 3:30PM - 4:30PM
Hot Topics 4
This session is from Nuclear Receptors: Orphan
Room: Red Cloud

Speaker 3 of 4
Jae In Lee, Amgen Inc., USA
ASC-2, as an Essential Transcriptional Coactivator of the Liver X Receptors in vivo


Wednesday, March 03 | 3:30PM - 4:30PM
Hot Topics 4
This session is from Nuclear Receptors: Orphan
Room: Red Cloud

Speaker 4 of 4
Hilde Irene Nebb, University of Oslo, Norway
Liver X Receptor Signaling Pathways in Adipose Tissue


Wednesday, March 03 | 5:00PM - 5:30PM
Coffee & Snacks Available
Room: Longs Peak Foyer


Wednesday, March 03 | 5:30PM - 7:30PM
Nuclear Receptor Round-Up (Joint). Session Sponsored in par
t by X-Ceptor Therapeutics, Inc.

Room: Red Cloud/Shavano/Torreys

Speaker 1 of 3
* David J. Mangelsdorf, University of Texas Southwestern Medical Center, USA

Wednesday, March 03 | 5:30PM - 7:30PM
Nuclear Receptor Round-Up (Joint). Session Sponsored in par
t by X-Ceptor Therapeutics, Inc.

Room: Red Cloud/Shavano/Torreys

Speaker 2 of 3
Bert W. O'Malley, Baylor College of Medicine, USA
Searching for Novel and Diverse Functions of Steroid Hormone Receptor Coactivators

Wednesday, March 03 | 5:30PM - 7:30PM
Nuclear Receptor Round-Up (Joint). Session Sponsored in par
t by X-Ceptor Therapeutics, Inc.

Room: Red Cloud/Shavano/Torreys

Speaker 3 of 3
Ronald M. Evans, HHMI/The Salk Institute, USA
Nuclear Receptors: The Final Word

Wednesday, March 03 | 7:30PM - 8:00PM
Social Hour
Room: Grays/Longs/Quandary


Wednesday, March 03 | 8:00PM - 11:00PM
Entertainment
Room: Grays/Longs/Quandary


Wednesday, March 03 | 8:00PM - 11:00PM
Cash Bar
Room: Grays/Longs/Quandary


Thursday, March 04 | 10:26AM - 10:26AM
Departure


*Session Chair.