Web Desc
Molecular Control of Adipogenesis and Obesity
joint with Diabetes Mellitus: Molecular Signaling, Genes and Therapeutics
Organizer(s): Stephen R. Farmer and Sheila Collins
Date: March 04 - 10, 2004
Location: Fairmont Banff Springs, Banff, AB, Canada
Sponsored by Abbott Laboratories and Biovitrum AB
Summary of Meeting:
The focus of this conference is on understanding the molecular mechanisms that control the formation and function of adipose tissue as well as understanding how various physiologic processes acting through adipose tissue regulate metabolism and energy homeostasis. This is a very timely conference since there has been an alarming increase in obesity and its associated disorders (most notably type 2 diabetes) throughout the United States and the Western World during the last 10 years. It is clear now that obesity is associated with an increased risk of diabetes. From 1991 to 2000, there was a 61% increase in obesity and 49% increase in type 2 diabetes among adults of both genders. The most exciting current research in this field includes: 1. Identification of the adipocyte as an endocrine cell which acts at the center of a complex physiologic process to control overall metabolism and energy balance by secreting hormones, cytokines and other peptides that regulate functions in the hypothalamus, muscle and liver. 2. Characterization of adipocyte-specific secreted proteins such as adiponectin that act on the liver and muscle to sensitize these tissues to insulin. 3. Continued on-going research on leptin - defining its mechanism of action within the brain and in the periphery. 4. The role of circulating fatty acids and their accumulation in peripheral tissues such as liver and muscle where they contribute to the insulin resistance observed in these tissues in obese individuals. 5. Identification and characterization of the signaling pathways and transcription factors that regulate the formation of adipose tissue (adipogenesis) and thermogenesis in adipocytes and muscle cells. 6. Elucidation of the role of nuclear hormone receptors and their associated cofactors in regulating glucose and lipid homeostasis. In addition, several of these receptors are targets for drug discovery to combat obesity and to sensitize individuals to insulin. This is most elegantly illustrated by the elucidation of the mechanism of action of the thiazolidinedione family of insulin sensitizers, which are ligands for PPAR gamma (the master regulator of adipogenesis). Some of the major problems are: Understanding the contribution of genetics versus the environment and life style to obesity and type 2 diabetes. Awaiting bioinformatics from the genome and proteome progects to help elucidate some of these problems. A further understanding of the integration of insulin-responsive tissues in regulating metabolism and energy balance. To identify new hormones and peptides that mediate the signaling processes among these different tissues. To determine why visceral fat depots are linked to a higher risk of cardiovascular disease and diabetes in obese individuals. The goal of this meeting is to bring together experts in the listed areas of research to present their lastest results so that the obesity and diabetes research community can integrate this information with their own observations to begin to understand the underlying cause of obesity and its related disorders. This meeting is strengthened by the fact that it is a joint meeting with Diabetes Mellitus: Molecular Mechanisms, Genetics and New Therapies, which will facilitate an even greater interaction across additional fields of expertise.
Discounted Abstract Deadline: November 3 2003
Discounted Registration Deadline: January 5 2004
We gratefully acknowledge additional support for this conference from:

Abbott Laboratories
Biovitrum AB
TestDiet division Purina Mills LLC
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 1R13DK067025-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Thursday, March 04 | 3:00PM - 7:00PM
Registration
Room: Van Horne Foyer


Thursday, March 04 | 6:15PM - 7:15PM
Refreshments
Room: Van Horne Foyer


Thursday, March 04 | 7:15PM - 7:30PM
Orientation
Room: Van Horne Ballroom


Thursday, March 04 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Van Horne Ballroom

Speaker 3 of 3
Stephen W. Fesik, Vanderbilt University School of Medicine, USA
RNAi for Target Identification and Validation

Thursday, March 04 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Van Horne Ballroom

Speaker 2 of 3
Allen M. Spiegel, National Institutes of Health, USA
The NIDDK Agenda for Support of Diabetes and Obesity Research

Thursday, March 04 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Van Horne Ballroom

Speaker 1 of 3
* Michael P. Czech, University of Massachusetts Medical School, USA

Friday, March 05 | 6:30AM - 8:00AM
Breakfast
Room: Alberta/Cascade/Conservatory/New Brunswick


Friday, March 05 | 8:00AM - 11:15AM
The Adipocyte as an Endocrine Cell: Regulation of Regulatio
n of Energy Metabolism, Brain, Muscle, and Liver and Beta Cells (Joint)

Room: Van Horne Ballroom

Speaker 2 of 7
Jeffrey M. Friedman, Rockefeller University, USA
Leptin and the Neural Circuit Regulating Weight and Food Intakeand the Adaptive Response to Starvation - Rapid Rewiring of the Arcute Neuclus

Friday, March 05 | 8:00AM - 11:15AM
The Adipocyte as an Endocrine Cell: Regulation of Regulatio
n of Energy Metabolism, Brain, Muscle, and Liver and Beta Cells (Joint)

Room: Van Horne Ballroom

Speaker 1 of 7
* Philipp E. Scherer, University of Texas Southwestern Medical Center, USA

Friday, March 05 | 8:00AM - 11:15AM
The Adipocyte as an Endocrine Cell: Regulation of Regulatio
n of Energy Metabolism, Brain, Muscle, and Liver and Beta Cells (Joint)

Room: Van Horne Ballroom

Speaker 3 of 7
Barbara B. Kahn, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
AMPK Regulates Food Intake by Responding to Leptin and Other Hormonal Signals and Nutrients in the Hypothalmus

Friday, March 05 | 8:00AM - 11:15AM
The Adipocyte as an Endocrine Cell: Regulation of Regulatio
n of Energy Metabolism, Brain, Muscle, and Liver and Beta Cells (Joint)

Room: Van Horne Ballroom

Speaker 4 of 7
Takashi Kadowaki, University of Tokyo, Japan
Adiponectin Receptors: Structure, Function and Signal Transduction Mechanism

Friday, March 05 | 8:00AM - 11:15AM
The Adipocyte as an Endocrine Cell: Regulation of Regulatio
n of Energy Metabolism, Brain, Muscle, and Liver and Beta Cells (Joint)

Room: Van Horne Ballroom

Speaker 5 of 7
Jeffrey Flier, Harvard University, USA
The Role of SOCS3 in Leptin and Insulin Action

Friday, March 05 | 8:00AM - 11:15AM
The Adipocyte as an Endocrine Cell: Regulation of Regulatio
n of Energy Metabolism, Brain, Muscle, and Liver and Beta Cells (Joint)

Room: Van Horne Ballroom

Speaker 6 of 7
Grant A. Mitchell, CHU Sainte-Justine, Canada
Short Talk: Hormone-Sensitive Lipase (HSL)-Independent Adipocyte Lipolysis during Beta Adrenergic Stimulation, Fasting and Dietary Fat Loading

Friday, March 05 | 8:00AM - 11:15AM
The Adipocyte as an Endocrine Cell: Regulation of Regulatio
n of Energy Metabolism, Brain, Muscle, and Liver and Beta Cells (Joint)

Room: Van Horne Ballroom

Speaker 7 of 7
E. Dale Abel, University of Iowa, Carver College of Medicine, USA
Short Talk: Mechanism by which Insulin Resistance Leads to Mitochondrial Dysfunction in Cardiac Muscle

Friday, March 05 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Foyer


Friday, March 05 | 11:15AM - 1:00PM
Poster Setup
Room: Alberta/Cascade/Conservatory/New Brunswick


Friday, March 05 | 1:00PM - 10:00PM
Poster Viewing
Room: Alberta/Cascade/Conservatory/New Brunswick


Friday, March 05 | 4:30PM - 4:45PM
Coffee & Snacks Available
Room: Van Horne Foyer


Friday, March 05 | 4:45PM - 7:00PM
Adipogenesis I: Signaling and Transcription Factors
Room: Van Horne C

Speaker 1 of 4
* Stephen R. Farmer, Boston University School of Medicine, USA

Friday, March 05 | 4:45PM - 7:00PM
Adipogenesis I: Signaling and Transcription Factors
Room: Van Horne C

Speaker 2 of 4
Ormond A. MacDougald, University of Michigan, USA
Role of Wnt Signaling in Development of Adipose Tissues and Bone

Friday, March 05 | 4:45PM - 7:00PM
Adipogenesis I: Signaling and Transcription Factors
Room: Van Horne C

Speaker 3 of 4
Jacqueline M. Stephens, Louisiana State University, USA
Crosstalk between STATs and PPARgamma in Adipocytes

Friday, March 05 | 4:45PM - 7:00PM
Adipogenesis I: Signaling and Transcription Factors
Room: Van Horne C

Speaker 4 of 4
Evan D. Rosen, Harvard University, USA
Transcriptional Pathways in Adipose-Selective Gene Expression

Friday, March 05 | 4:45PM - 7:00PM
Regulated Secretory Pathways in Adipocytes and Beta Cells
This session is from Diabetes Mellitus
Room: Van Horne A/B

Speaker 1 of 6
* Amira Klip, Hospital for Sick Children, Canada


Friday, March 05 | 4:45PM - 7:00PM
Regulated Secretory Pathways in Adipocytes and Beta Cells
This session is from Diabetes Mellitus
Room: Van Horne A/B

Speaker 2 of 6
Harvey Lodish, Whitehead Institute for Biomedical Research, USA
Signaling by Acrp30/ Adiponectin


Friday, March 05 | 4:45PM - 7:00PM
Regulated Secretory Pathways in Adipocytes and Beta Cells
This session is from Diabetes Mellitus
Room: Van Horne A/B

Speaker 3 of 6
Timothy E. McGraw, Weill Medical College of Cornell University, USA
GLUT4 Trafficking Pathways


Friday, March 05 | 4:45PM - 7:00PM
Regulated Secretory Pathways in Adipocytes and Beta Cells
This session is from Diabetes Mellitus
Room: Van Horne A/B

Speaker 4 of 6
Christopher J. Rhodes, AstraZeneca, USA
Regulation of Insulin Exocytosis beyond Generating Secondary Signals


Friday, March 05 | 4:45PM - 7:00PM
Regulated Secretory Pathways in Adipocytes and Beta Cells
This session is from Diabetes Mellitus
Room: Van Horne A/B

Speaker 5 of 6
Peter A. Antinozzi, Wake Forest School of Medicine, USA
Short Talk: A RNAi-Based Genetic Screen of Mitochondrial Enzymes Identified Pyruvate Carboxylase as an Essential Gene in Facilitating Glucose-Stimulated Insulin Secretion


Friday, March 05 | 4:45PM - 7:00PM
Regulated Secretory Pathways in Adipocytes and Beta Cells
This session is from Diabetes Mellitus
Room: Van Horne A/B

Speaker 6 of 6
Ruth E. Gimeno, Eli Lilly and Company, USA
Short Talk: Deletion of FATP5 Reveals a Role for Bile Acid Recycling in Body Weight Homeostasis


Friday, March 05 | 7:30PM - 8:30PM
Social Hour
Room: Alberta/Cascade/Conservatory/New Brunswick


Friday, March 05 | 7:30PM - 10:00PM
Poster Session 1
Room: Alberta/Cascade/Conservatory/New Brunswick


Saturday, March 06 | 6:30AM - 8:00AM
Breakfast
Room: Alberta/Cascade/Conservatory/New Brunswick


Saturday, March 06 | 8:00AM - 11:00AM
Stem Cells and Development of Insulin Responsive Tissues (Jo
int)

Room: Van Horne Ballroom

Speaker 1 of 5
* Douglas A. Melton, Harvard University, USA
Stem Cells for Pancreatic Development

Saturday, March 06 | 8:00AM - 11:00AM
Stem Cells and Development of Insulin Responsive Tissues (Jo
int)

Room: Van Horne Ballroom

Speaker 2 of 5
Chris Wright, Vanderbilt University Medical Center, USA
Pancreas/Forecut Develoment - Response to PDX1 Gene Dosage

Saturday, March 06 | 8:00AM - 11:00AM
Stem Cells and Development of Insulin Responsive Tissues (Jo
int)

Room: Van Horne Ballroom

Speaker 3 of 5
Ronald M. Evans, HHMI/The Salk Institute, USA
Nuclear Receptors and the Complex Journey to Obesity

Saturday, March 06 | 8:00AM - 11:00AM
Stem Cells and Development of Insulin Responsive Tissues (Jo
int)

Room: Van Horne Ballroom

Speaker 4 of 5
Duncan Odom, University of Cambridge, UK
Short Talk: A Broad Role for HNF4alpha in Pancreatic Islet Transcription

Saturday, March 06 | 8:00AM - 11:00AM
Stem Cells and Development of Insulin Responsive Tissues (Jo
int)

Room: Van Horne Ballroom

Speaker 5 of 5
Donalyn Scheuner, University of Michigan, USA
Short Talk: Translational Control is Required to Prevent High-Fat Diet-Induced Diabetes and Obesity

Saturday, March 06 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Foyer


Saturday, March 06 | 11:00AM - 1:00PM
Poster Setup
Room: Alberta/Cascade/Conservatory/New Brunswick


Saturday, March 06 | 1:00PM - 10:00PM
Poster Viewing
Room: Alberta/Cascade/Conservatory/New Brunswick


Saturday, March 06 | 2:00PM - 4:00PM
Hot Topics 1
Room: Van Horne C

Speaker 1 of 8
Bernard Binétruy, INSERM, France
Mice Lacking ERK1 Have Less Fat and are Protected from Diet-Induced Obesity

Saturday, March 06 | 2:00PM - 4:00PM
Hot Topics 1
Room: Van Horne C

Speaker 2 of 8
Paul S. Cooke, University of Illinois at Urbana-Champaign, USA
Knockout of the Cell Cycle Regulators p27Kip1 and/or p21Cip1 Produces Adipocyte Hyperplasia and Obesity

Saturday, March 06 | 2:00PM - 4:00PM
Hot Topics 1
Room: Van Horne C

Speaker 3 of 8
Melina Fan, Addgene, USA
p160MBP Repression of PGCI in the Absence of p38 Activity

Saturday, March 06 | 2:00PM - 4:00PM
Hot Topics 1
Room: Van Horne C

Speaker 4 of 8
Jacob E. Friedman, University of Oklahoma, USA
Deletion of CCAT/Enhancer Binding Protein beta (C/EBP beta) Attenuates Diabetes and Steatotosis in Leprdb/db Mice

Saturday, March 06 | 2:00PM - 4:00PM
Hot Topics 1
Room: Van Horne C

Speaker 5 of 8
Kira R. Gantt, East Carolina University Brody School of Medicine, USA
HuR Binds and Shuttles C/EBP-beta mRNA to the Cytosol, An Early Event in Adipogenesis

Saturday, March 06 | 2:00PM - 4:00PM
Hot Topics 1
Room: Van Horne C

Speaker 6 of 8
Justin J. Rochford, University of Aberdeen, UK
ETO is a Novel Inhibitor of C/EBPbeta Involved in the Hormonal Control of Adipogenesis

Saturday, March 06 | 2:00PM - 4:00PM
Hot Topics 1
Room: Van Horne C

Speaker 7 of 8
Robert L. Kortum, National Cancer Institute, National Institutes of Health, USA
The Molecular Scaffold Kinase Suppressor of Ras 1 (KSR1) Regulates ERK Activation and Determines Adipogenic Potential

Saturday, March 06 | 2:00PM - 4:00PM
Hot Topics 1
Room: Van Horne C

Speaker 8 of 8
Chih-Hao Lee, Harvard University School of Public Health, USA
PPAR delta Facilitates VLDL-Derived Fatty Acid Catabolism in the Macrophage

Saturday, March 06 | 4:30PM - 4:45PM
Coffee & Snacks Available
Room: Van Horne Foyer


Saturday, March 06 | 4:45PM - 7:00PM
Adipogenesis II: Chromatin and Coregulators
Room: Van Horne C

Speaker 1 of 4
Robert G. Roeder, Rockefeller University, USA
Function of Diverse PPARgamma Coactivators in Adipogenesis

Saturday, March 06 | 4:45PM - 7:00PM
Adipogenesis II: Chromatin and Coregulators
Room: Van Horne C

Speaker 2 of 4
Anthony N. Imbalzano, University of Massachusetts Medical School, USA
Activation of PPARgamma2 Expression during Adipogenesis

Saturday, March 06 | 4:45PM - 7:00PM
Adipogenesis II: Chromatin and Coregulators
Room: Van Horne C

Speaker 3 of 4
* Johan Auwerx, École Polytechnique Fédérale de Lausanne, Switzerland
Cofactors and Nuclear Receptors in the Control of Adipometabolism

Saturday, March 06 | 4:45PM - 7:00PM
Adipogenesis II: Chromatin and Coregulators
Room: Van Horne C

Speaker 4 of 4
Mark Christian, Imperial College London, UK
Short Talk: RIP140 Co-Repressor is a Key Regulator of Adipose Biology

Saturday, March 06 | 4:45PM - 7:15PM
Signaling and Secretion Networks
This session is from Diabetes Mellitus
Room: Van Horne A/B

Speaker 1 of 6
* Yoshitomo Oka, Tohoku University Graduate School of Medicine, Japan


Saturday, March 06 | 4:45PM - 7:15PM
Signaling and Secretion Networks
This session is from Diabetes Mellitus
Room: Van Horne A/B

Speaker 2 of 6
David Ron, University of Cambridge, UK
Stress Signal Integration by Phosphorylated Translation Initiation Factor 2 (eIF2alpha)


Saturday, March 06 | 4:45PM - 7:15PM
Signaling and Secretion Networks
This session is from Diabetes Mellitus
Room: Van Horne A/B

Speaker 3 of 6
Morris F. White, Boston Children's Hospital, Harvard Medical School, USA
Coordinate Regulation by the IRS Proteins


Saturday, March 06 | 4:45PM - 7:15PM
Signaling and Secretion Networks
This session is from Diabetes Mellitus
Room: Van Horne A/B

Speaker 4 of 6
Michael P. Czech, University of Massachusetts Medical School, USA
Analysis of Insulin Signaling through RNAi-based Gene Silencing


Saturday, March 06 | 4:45PM - 7:15PM
Signaling and Secretion Networks
This session is from Diabetes Mellitus
Room: Van Horne A/B

Speaker 5 of 6
Morris J. Birnbaum, Pfizer Inc., USA
Regulation of Growth and Metabolism by Akt/PKB


Saturday, March 06 | 4:45PM - 7:15PM
Signaling and Secretion Networks
This session is from Diabetes Mellitus
Room: Van Horne A/B

Speaker 6 of 6
Mark W. Sleeman, Regeneron Pharmaceuticals, USA
Short Talk: Identification and Characterization of Novel Genes Associated with Obesity/Diabetes by a High-Throughput KO Process, VelociGene®


Saturday, March 06 | 7:30PM - 8:30PM
Social Hour
Room: Alberta/Cascade/Conservatory/New Brunswick


Saturday, March 06 | 7:30PM - 10:00PM
Poster Session 2
Room: Alberta/Cascade/Conservatory/New Brunswick


Sunday, March 07 | 6:30AM - 8:00AM
Breakfast
Room: Alberta/Cascade/Conservatory/New Brunswick


Sunday, March 07 | 8:00AM - 11:00AM
PPARs, Orphan Receptors and Metabolism
Room: Van Horne C

Speaker 1 of 4
Andrea L. Hevener, University of California, Los Angeles, USA
Role of Skeletal Muscle and Adipocyte PPARgamma Receptors in Insulin Sensitivity in Thiazoladinedione Action

Sunday, March 07 | 8:00AM - 11:00AM
PPARs, Orphan Receptors and Metabolism
Room: Van Horne C

Speaker 2 of 4
* Barbara C. Hansen, University of South Florida, Tampa, USA
PPAR’s and their Calorie-Restriction Mimetic Effects in Non Human Primates

Sunday, March 07 | 8:00AM - 11:00AM
PPARs, Orphan Receptors and Metabolism
Room: Van Horne C

Speaker 3 of 4
Yaacov Barak, Magee-Womens Research Institute, USA
Studies of Adipogenesis and Insulin Resistance by Genetically Manipulating PPAR gamma

Sunday, March 07 | 8:00AM - 11:00AM
PPARs, Orphan Receptors and Metabolism
Room: Van Horne C

Speaker 4 of 4
Stephen R. Farmer, Boston University School of Medicine, USA
Signaling Pathways Regulating PPARgamma Activity during Adipogenesis

Sunday, March 07 | 8:00AM - 9:30AM
Insulin Signaling to GLUT4: Breaking Stories
This session is from Diabetes Mellitus
Room: Van Horne A/B

Speaker 1 of 3
* Jeffrey E. Pessin, Albert Einstein College of Medicine, USA


Sunday, March 07 | 8:00AM - 9:30AM
Insulin Signaling to GLUT4: Breaking Stories
This session is from Diabetes Mellitus
Room: Van Horne A/B

Speaker 2 of 3
Konstantin V. Kandror, Boston University School of Medicine, USA
Formation of the Insulin-Responsive Vesicles in 3T3-L1 Adipocytes


Sunday, March 07 | 8:00AM - 9:30AM
Insulin Signaling to GLUT4: Breaking Stories
This session is from Diabetes Mellitus
Room: Van Horne A/B

Speaker 3 of 3
Jonathan S. Bogan, Yale University School of Medicine, USA
Molecular Regulation of GLUT4 Trafficking


Sunday, March 07 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Foyer


Sunday, March 07 | 9:50AM - 11:15AM
Panel Discussion: PI3-Kinase-Dependent and -Independent Path
s for Insulin-Regulated GLUT4 Translocation? At what steps is it Required?
This session is from Diabetes Mellitus
Room: Van Horne A/B

Speaker 1 of 8
* Morris J. Birnbaum, Pfizer Inc., USA


Sunday, March 07 | 9:50AM - 11:15AM
Panel Discussion: PI3-Kinase-Dependent and -Independent Path
s for Insulin-Regulated GLUT4 Translocation? At what steps is it Required?
This session is from Diabetes Mellitus
Room: Van Horne A/B

Speaker 2 of 8
Alan R. Saltiel, University of California, San Diego, USA
CAP/Cb1 TC10 Pathway


Sunday, March 07 | 9:50AM - 11:15AM
Panel Discussion: PI3-Kinase-Dependent and -Independent Path
s for Insulin-Regulated GLUT4 Translocation? At what steps is it Required?
This session is from Diabetes Mellitus
Room: Van Horne A/B

Speaker 3 of 8
Jeremy M. Tavaré, University of Bristol, UK
Glut4 Translocation/Trafficking


Sunday, March 07 | 9:50AM - 11:15AM
Panel Discussion: PI3-Kinase-Dependent and -Independent Path
s for Insulin-Regulated GLUT4 Translocation? At what steps is it Required?
This session is from Diabetes Mellitus
Room: Van Horne A/B

Speaker 4 of 8
Paul F. Pilch, Boston University School of Medicine, USA
Lipid Microdomains IR Receptor and Caveolin


Sunday, March 07 | 9:50AM - 11:15AM
Panel Discussion: PI3-Kinase-Dependent and -Independent Path
s for Insulin-Regulated GLUT4 Translocation? At what steps is it Required?
This session is from Diabetes Mellitus
Room: Van Horne A/B

Speaker 5 of 8
David E. James, University of Sydney, Australia
Insulin Regulation of Glucose Transport by Akt-Dependent and Independent Pathways


Sunday, March 07 | 9:50AM - 11:15AM
Panel Discussion: PI3-Kinase-Dependent and -Independent Path
s for Insulin-Regulated GLUT4 Translocation? At what steps is it Required?
This session is from Diabetes Mellitus
Room: Van Horne A/B

Speaker 6 of 8
Amira Klip, Hospital for Sick Children, Canada
PI3-Kinase Inputs in GLUT4 Compartmentalization and Membrane Fusion


Sunday, March 07 | 9:50AM - 11:15AM
Panel Discussion: PI3-Kinase-Dependent and -Independent Path
s for Insulin-Regulated GLUT4 Translocation? At what steps is it Required?
This session is from Diabetes Mellitus
Room: Van Horne A/B

Speaker 7 of 8
Yannick Le Marchand-Brustel, INSERM, France
Pathway for Osmotic Stress Induced Glucose Uptake


Sunday, March 07 | 9:50AM - 11:15AM
Panel Discussion: PI3-Kinase-Dependent and -Independent Path
s for Insulin-Regulated GLUT4 Translocation? At what steps is it Required?
This session is from Diabetes Mellitus
Room: Van Horne A/B

Speaker 8 of 8
Jeffrey E. Pessin, Albert Einstein College of Medicine, USA
Insulin Stimulated Trafficking


Sunday, March 07 | 11:00AM - 1:00PM
Poster Setup
Room: Alberta/Cascade/Conservatory/New Brunswick


Sunday, March 07 | 1:00PM - 10:00PM
Poster Viewing
Room: Alberta/Cascade/Conservatory/New Brunswick


Sunday, March 07 | 2:00PM - 4:00PM
Hot Topics 2

Speaker 1 of 8
Hei Sook Sul, University of California, Berkeley, USA
ADSF/Resistin Inhibits Adipogenesis but Improves Insulin Sensitivity

Sunday, March 07 | 2:00PM - 4:00PM
Hot Topics 2

Speaker 2 of 8
Claire M. Steppan, University of Pennsylvania, USA
SOCS3 is a Potential Mediator of Resistin Antagonism of Insulin Action

Sunday, March 07 | 2:00PM - 4:00PM
Hot Topics 2

Speaker 3 of 8
Nathan E. Wolins, Washington University, USA
Adipocytes Remodel to Accommodate Rapid Triacylglycerol Synthesis and Packaging

Sunday, March 07 | 2:00PM - 4:00PM
Hot Topics 2

Speaker 4 of 8
Stuart P. Weisberg, Columbia University, USA
Obesity is Associated with Macrophage Accumulation in Adipose Tissue

Sunday, March 07 | 2:00PM - 4:00PM
Hot Topics 2

Speaker 5 of 8
Kristoffer Ström, Lund University, Sweden
Investigations into the Resistance to Diet-Induced Obesity and Adipose Tissue Insulin Resistance of Hormone-Sensitive Lipase Deficient Mice

Sunday, March 07 | 2:00PM - 4:00PM
Hot Topics 2

Speaker 6 of 8
Femke Streijger, Universitair Medisch Centrum, St. Radboud, NCMLS, Netherlands
Mice Deficient for Both Brain-Type Creatine Kinases have Smaller White Adipocytes and A Reduced Lipid Content in Brown Adipocytes

Sunday, March 07 | 2:00PM - 4:00PM
Hot Topics 2

Speaker 7 of 8
Marc R. Van Gilst, Fred Hutchinson Cancer Research Center, USA
Nuclear Hormone Receptors in C. Elegans

Sunday, March 07 | 2:00PM - 4:00PM
Hot Topics 2

Speaker 8 of 8
Peteris Alberts, Biovitrum, Sweden
The 11beta-Hydroxysteroid Dehydrogenase Type 1 Inhibitor BVT.2733 has Beneficial Effects in Three Mouse Models of Obesity and Diabetes, Including DIO Mice

Sunday, March 07 | 4:30PM - 4:45PM
Coffee & Snacks Available
Room: Van Horne Foyer


Sunday, March 07 | 4:45PM - 7:00PM
Signaling, Nuclear Factors and Glucose Homeostasis (Joint)
Room: Van Horne Ballroom

Speaker 1 of 5
* Richard W. Hanson, Case Western Reserve University School of Medicine, USA

Sunday, March 07 | 4:45PM - 7:00PM
Signaling, Nuclear Factors and Glucose Homeostasis (Joint)
Room: Van Horne Ballroom

Speaker 2 of 5
Vamsi K. Mootha, Massachusetts General Hospital, USA
Short Talk: Genomics Approaches to Human Diabetes

Sunday, March 07 | 4:45PM - 7:00PM
Signaling, Nuclear Factors and Glucose Homeostasis (Joint)
Room: Van Horne Ballroom

Speaker 3 of 5
Roger J. Davis, HHMI/University of Massachusetts Medical School, USA
Signal Transduction by Stress-Activated MAP Kinases

Sunday, March 07 | 4:45PM - 7:00PM
Signaling, Nuclear Factors and Glucose Homeostasis (Joint)
Room: Van Horne Ballroom

Speaker 4 of 5
Domenico Accili, Columbia University, USA
Regulation of Insulin-Dependent Gene Expression by the fFrkhead Transcription Factor Foxo1

Sunday, March 07 | 4:45PM - 7:00PM
Signaling, Nuclear Factors and Glucose Homeostasis (Joint)
Room: Van Horne Ballroom

Speaker 5 of 5
Gary B. Ruvkun, Massachusetts General Hospital, Harvard Medical School, USA
Fat Storage in C. Elegans

Sunday, March 07 | 7:30PM - 8:30PM
Social Hour
Room: Alberta/Cascade/Conservatory/New Brunswick


Sunday, March 07 | 7:30PM - 10:00PM
Poster Session 3
Room: Alberta/Cascade/Conservatory/New Brunswick


Monday, March 08 | 6:30AM - 8:00AM
Breakfast
Room: Alberta/Cascade/Conservatory/New Brunswick


Monday, March 08 | 8:00AM - 11:00AM
Genes and Signals Controlling White and Brown Adipocyte Func
tion

Room: Van Horne C

Speaker 1 of 4
* Sheila Collins, Vanderbilt University Medical Center, USA
Components of the PKA -> p38 MAPK Signaling Cascade in Adipocytes

Monday, March 08 | 8:00AM - 11:00AM
Genes and Signals Controlling White and Brown Adipocyte Func
tion

Room: Van Horne C

Speaker 2 of 4
Leslie P. Kozak, Polish Academy of Sciences, Poland
Genetic Variation in Regulatory Pathways Associated with Brown Adipocyte Induction

Monday, March 08 | 8:00AM - 11:00AM
Genes and Signals Controlling White and Brown Adipocyte Func
tion

Room: Van Horne C

Speaker 3 of 4
Iichiro Shimomura, Osaka University, Japan
New Molecular Target of Obesity-Related Metabolic Syndrome

Monday, March 08 | 8:00AM - 11:00AM
Genes and Signals Controlling White and Brown Adipocyte Func
tion

Room: Van Horne C

Speaker 4 of 4
Karsten Kristiansen, University of Copenhagen, Denmark
The Retinoblastoma Protein is a Regulator of White Versus Brown Adipocyte Differentiation

Monday, March 08 | 8:00AM - 11:15AM
Lessons from Expressed Gene and Proteome Databases
This session is from Diabetes Mellitus
Room: Van Horne A/B

Speaker 1 of 7
* Mary-Elizabeth Patti, Joslin Diabetes Center, USA


Monday, March 08 | 8:00AM - 11:15AM
Lessons from Expressed Gene and Proteome Databases
This session is from Diabetes Mellitus
Room: Van Horne A/B

Speaker 2 of 7
Klaus H. Kaestner, University of Pennsylvania School of Medicine, USA
Functional Genomics of the Beta-Cell: From Libraries to Targets


Monday, March 08 | 8:00AM - 11:15AM
Lessons from Expressed Gene and Proteome Databases
This session is from Diabetes Mellitus
Room: Van Horne A/B

Speaker 3 of 7
Silvia Corvera, University of Massachusetts Medical School, USA
Proteomic Analysis of TZD Actions


Monday, March 08 | 8:00AM - 11:15AM
Lessons from Expressed Gene and Proteome Databases
This session is from Diabetes Mellitus
Room: Van Horne A/B

Speaker 4 of 7
Alan D. Attie, University of Wisconsin-Madison, USA
Genetic and Genomic Dissection of Diabetes in Mice


Monday, March 08 | 8:00AM - 11:15AM
Lessons from Expressed Gene and Proteome Databases
This session is from Diabetes Mellitus
Room: Van Horne A/B

Speaker 5 of 7
Yoshitomo Oka, Tohoku University Graduate School of Medicine, Japan
A Role of Wolfram Syndrome Gene in Beta Cell Apoptosis and Stimulus-Secretion Coupling


Monday, March 08 | 8:00AM - 11:15AM
Lessons from Expressed Gene and Proteome Databases
This session is from Diabetes Mellitus
Room: Van Horne A/B

Speaker 6 of 7
Xiaoli Chen, National Institutes of Health, USA
Short Talk: Identification of Insulin-Regulated Secretory Proteins in Rat Adipose Cells and their Relevance to Insulin Resistance


Monday, March 08 | 8:00AM - 11:15AM
Lessons from Expressed Gene and Proteome Databases
This session is from Diabetes Mellitus
Room: Van Horne A/B

Speaker 7 of 7
Marie S. Thearle, NIH/NIDDK/PECRB, USA
Short Talk: Body Mass-Hepatic Quantitative Trait Transcripts - A Common Set of Hepatic Transcripts Regulated by Body Mass


Monday, March 08 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Foyer


Monday, March 08 | 11:00AM - 1:00PM
Poster Setup
Room: Alberta/Cascade/Conservatory/New Brunswick


Monday, March 08 | 1:00PM - 10:00PM
Poster Viewing
Room: Alberta/Cascade/Conservatory/New Brunswick


Monday, March 08 | 4:30PM - 4:45PM
Coffee & Snacks Available
Room: Van Horne Foyer


Monday, March 08 | 4:45PM - 7:30PM
Diabetes and Obesity Genes (Joint)
Room: Van Horne Ballroom

Speaker 1 of 5
* Masato Kasuga, National Center for Global Health and Medicine, Japan

Monday, March 08 | 4:45PM - 7:30PM
Diabetes and Obesity Genes (Joint)
Room: Van Horne Ballroom

Speaker 2 of 5
Vijay K. Yechoor, University of Pittsburgh, USA
Genetic Analysis of Insulin and Diabetes Regulated Gene Expression

Monday, March 08 | 4:45PM - 7:30PM
Diabetes and Obesity Genes (Joint)
Room: Van Horne Ballroom

Speaker 3 of 5
Stephen O'Rahilly, University of Cambridge, UK
Human Genetics of Extreme Phenotypes

Monday, March 08 | 4:45PM - 7:30PM
Diabetes and Obesity Genes (Joint)
Room: Van Horne Ballroom

Speaker 4 of 5
Philippe Froguel, Imperial College of London, UK
Genetics of Obesity from a Polygenic Perspective

Monday, March 08 | 4:45PM - 7:30PM
Diabetes and Obesity Genes (Joint)
Room: Van Horne Ballroom

Speaker 5 of 5
T. Keith Blackwell, Joslin Diabetes Center and Harvard Medical School, USA
Short Talk: Regulation of a Conserved Oxidative Stress Defense in C. elegans

Monday, March 08 | 7:30PM - 8:30PM
Social Hour
Room: Alberta/Cascade/Conservatory/New Brunswick


Monday, March 08 | 7:30PM - 10:00PM
Poster Session 4
Room: Alberta/Cascade/Conservatory/New Brunswick


Tuesday, March 09 | 6:30AM - 8:00AM
Breakfast
Room: Alberta/Cascade/Conservatory/New Brunswick


Tuesday, March 09 | 8:00AM - 11:00AM
Control of Lipid Metabolism. Session Sponsored in part by L
ipomics Technologies, Inc.

Room: Van Horne C

Speaker 1 of 4
Dawn L. Brasaemle, Rutgers University, USA
Perilipin and the Control of Lipolysis in Adipocytes

Tuesday, March 09 | 8:00AM - 11:00AM
Control of Lipid Metabolism. Session Sponsored in part by L
ipomics Technologies, Inc.

Room: Van Horne C

Speaker 2 of 4
* Rosalind A. Coleman, University of North Carolina at Chapel Hill, USA
Regulation of Triacylglycerol Biosynthesis by GPAT

Tuesday, March 09 | 8:00AM - 11:00AM
Control of Lipid Metabolism. Session Sponsored in part by L
ipomics Technologies, Inc.

Room: Van Horne C

Speaker 3 of 4
Karen Reue, University of California, Los Angeles, USA
Lipin, A Modulator of Adiposity

Tuesday, March 09 | 8:00AM - 11:00AM
Control of Lipid Metabolism. Session Sponsored in part by L
ipomics Technologies, Inc.

Room: Van Horne C

Speaker 4 of 4
Philipp E. Scherer, University of Texas Southwestern Medical Center, USA
Title to be Determined

Tuesday, March 09 | 8:00AM - 11:15AM
Role of Cytokines in Type II Diabetes and Insulin Resistance
This session is from Diabetes Mellitus
Room: Van Horne A/B

Speaker 1 of 7
* André Marette, Laval University Hospital Research Center, Canada


Tuesday, March 09 | 8:00AM - 11:15AM
Role of Cytokines in Type II Diabetes and Insulin Resistance
This session is from Diabetes Mellitus
Room: Van Horne A/B

Speaker 2 of 7
Steven E. Shoelson, Harvard Medical School, Joslin Diabetes Center, USA
Inflammation in Insulin Resistance: Pathogenic Mediator and Target for Reversal


Tuesday, March 09 | 8:00AM - 11:15AM
Role of Cytokines in Type II Diabetes and Insulin Resistance
This session is from Diabetes Mellitus
Room: Van Horne A/B

Speaker 3 of 7
Gökhan S. Hotamisligil, Harvard School of Public Health, USA
Crossroads between Inflammatory and Metabolic Pathways in Diabetes


Tuesday, March 09 | 8:00AM - 11:15AM
Role of Cytokines in Type II Diabetes and Insulin Resistance
This session is from Diabetes Mellitus
Room: Van Horne A/B

Speaker 4 of 7
D. Grahame Hardie, University of Dundee, UK
The LKBI —> AMPK Pathway: A Key Target for Anti-Diabetic Drugs


Tuesday, March 09 | 8:00AM - 11:15AM
Role of Cytokines in Type II Diabetes and Insulin Resistance
This session is from Diabetes Mellitus
Room: Van Horne A/B

Speaker 5 of 7
Roger H. Unger, University of Texas Southwestern Medical Center, USA
Lipotoxic Diseases and their Prevention by Adipocytokines


Tuesday, March 09 | 8:00AM - 11:15AM
Role of Cytokines in Type II Diabetes and Insulin Resistance
This session is from Diabetes Mellitus
Room: Van Horne A/B

Speaker 6 of 7
Matthias Hundt, La Jolla Institute for Allergy and Immunology, USA
Short Talk: Increased Insulin Sensitivity in Mice Lacking Protein Kinase C theta


Tuesday, March 09 | 8:00AM - 11:15AM
Role of Cytokines in Type II Diabetes and Insulin Resistance
This session is from Diabetes Mellitus
Room: Van Horne A/B

Speaker 7 of 7
Min Chen, NIDDK, National Institutes of Health, USA
Short Talk: Glucose Intolerance Despite Normal Insulin Secretion and Responsiveness in Mice with Muscle-Specific Gs-alpha Deficiency


Tuesday, March 09 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Foyer


Tuesday, March 09 | 4:30PM - 4:45PM
Coffee & Snacks Available
Room: Van Horne Foyer


Tuesday, March 09 | 4:45PM - 7:00PM
Metabolic Cross Talk (Joint)
Room: Van Horne Ballroom

Speaker 1 of 4
* Juleen R. Zierath, Karolinska Institutet, Sweden
Defining Limits of Metabolic Performance

Tuesday, March 09 | 4:45PM - 7:00PM
Metabolic Cross Talk (Joint)
Room: Van Horne Ballroom

Speaker 2 of 4
Gerald I. Shulman, Yale University School of Medicine, USA
Unraveling the Mechanism of Insulin Resistance in Man: Potential Role of Mitochondrial Dysfunction

Tuesday, March 09 | 4:45PM - 7:00PM
Metabolic Cross Talk (Joint)
Room: Van Horne Ballroom

Speaker 3 of 4
Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA
Update on Resistin

Tuesday, March 09 | 4:45PM - 7:00PM
Metabolic Cross Talk (Joint)
Room: Van Horne Ballroom

Speaker 4 of 4
Katja A. Lamia, The Scripps Research Institute, USA
Short Talk: p15P4KBeta Modulates Insulin Response

Tuesday, March 09 | 7:30PM - 8:30PM
Social Hour
Room: Alberta/New Brunswick/Riverview


Tuesday, March 09 | 8:00PM - 11:00PM
Entertainment
Room: Alberta/New Brunswick/Riverview


Tuesday, March 09 | 8:30PM - 11:00PM
Cash Bar
Room: Alberta/New Brunswick/Riverview


Wednesday, March 10 | 10:26AM - 10:26AM
Departure


*Session Chair.