Web Desc
Molecular Biology of Cardiac Disease
joint with Cardiac Development and Congenital Heart Disease
Organizer(s): Jonathan G. Seidman and Christine E. Seidman
Date: March 07 - 12, 2004
Location: Keystone Resort, Keystone, CO, USA
Sponsored by The Director's Sponsor Fund
For important information on the coronavirus, please click here
Summary of Meeting:
Modern technologies are identifying the molecular mechanisms leading to heart disease, a leading cause of death in the United States. Over the past several years, mutations leading to some forms of hypertrophic cardiomyopathy, dilated cardiomyopathy, cardiac arrhythmias, atrial fibrillation, and congenital heart disease have been identified. The process of disease gene identification continues and we anticipate that new discoveries will be discussed at this meeting. Most of these disease gene identifications define steps in cardiac development or cardiac physiology. The identification of disease causing mutations leads to new challenges: How do these mutations cause disease? Does understanding the mechanisms that lead to disease lead to therapies? Bringing together cardiac physiologists, developmental biologists, human geneticists and cardiologists will allow interactions that should help address these questions.
Discounted Abstract Deadline: November 24 2003
Discounted Registration Deadline: January 7 2004
We gratefully acknowledge the generous grant for this conference provided by:

National Heart, Lung, and Blood Institute (NHLBI)
Grant No. 1R13HL076493-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 07 | 3:00PM - 7:00PM
Registration
Room: Longs Peak Foyer


Sunday, March 07 | 6:15PM - 7:15PM
Refreshments
Room: Longs Peak Foyer


Sunday, March 07 | 7:15PM - 7:30PM
Orientation
Room: Grays/Longs Peak


Sunday, March 07 | 7:30PM - 8:30PM
Keynote Address: Molecular Motors
Room: Grays/Longs Peak

Speaker 1 of 2
* Christine E. Seidman, Harvard Medical School, USA

Sunday, March 07 | 7:30PM - 8:30PM
Keynote Address: Molecular Motors
Room: Grays/Longs Peak

Speaker 2 of 2
James A. Spudich, Stanford University, USA
The Myosin Family of Molecular Motors: Diversity of Function and Mechanism

Monday, March 08 | 7:00AM - 8:00AM
Breakfast
Room: Shavano/Torreys


Monday, March 08 | 8:00AM - 11:00AM
Sarcomere Proteins and Hypertrophy
Room: Grays

Speaker 1 of 5
Jonathan G. Seidman, Harvard Medical School, USA
Hypertrophic Cardiomyopathy in Mice and Man


Monday, March 08 | 8:00AM - 11:00AM
Sarcomere Proteins and Hypertrophy
Room: Grays

Speaker 2 of 5
Neal D. Epstein, National Institutes of Health, USA
The Role of Myosin Light Chain Phosphorylation in Regulating the Cardiac Stretch-Activation Response

Monday, March 08 | 8:00AM - 11:00AM
Sarcomere Proteins and Hypertrophy
Room: Grays

Speaker 3 of 5
* Leslie A. Leinwand, University of Colorado Boulder, USA
Molecular Mechanisms of Cardiac Adaptations

Monday, March 08 | 8:00AM - 11:00AM
Sarcomere Proteins and Hypertrophy
Room: Grays

Speaker 4 of 5
Deborah L. Yelon, University of California, San Diego, USA
Primary and Secondary Effects of Chamber-Specific Myosin Heavy Chain Defects in Zebrafish

Monday, March 08 | 8:00AM - 11:00AM
Sarcomere Proteins and Hypertrophy
Room: Grays

Speaker 5 of 5
Sharlene M. Day, University of Pennsylvania, USA
Short Talk: Transgenic and Gene Transfer-Based Expression of Cardiac Troponin I Mutant A164H Increases Myofilament Calcium Sensitivity Under Acidic Conditions

Monday, March 08 | 8:00AM - 11:00AM
Cardiac Specification
This session is from Cardiac Development
Room: Longs Peak

Speaker 1 of 5
Manfred Frasch, Mount Sinai School of Medicine, USA
Induction and Function of T-Box Genes during Cardiac and Visceral Muscle Specification in Drosophila


Monday, March 08 | 8:00AM - 11:00AM
Cardiac Specification
This session is from Cardiac Development
Room: Longs Peak

Speaker 2 of 5
Andrew B. Lassar, Harvard Medical School, USA
Signaling Pathways that Regulate Heart Formation


Monday, March 08 | 8:00AM - 11:00AM
Cardiac Specification
This session is from Cardiac Development
Room: Longs Peak

Speaker 3 of 5
* Mark Mercola, Stanford University, USA
Molecular Relays for Heart Induction: Identification of Proteins that Act Downstream of Wnt Antagonists and Notch to Regulate Cardiac Cell Fate


Monday, March 08 | 8:00AM - 11:00AM
Cardiac Specification
This session is from Cardiac Development
Room: Longs Peak

Speaker 4 of 5
Richard P. Harvey, University of New South Wales, Victor Chang Cardiac Research Institute, Australia
Transcriptional Control of Cardiac Chamber Formation


Monday, March 08 | 8:00AM - 11:00AM
Cardiac Specification
This session is from Cardiac Development
Room: Longs Peak

Speaker 5 of 5
Ching-Pin Chang, Indiana University, USA
Short Talk: Repression of VEGF Expression by NFAT Underlies Initiation of Heart Valve Morphogenesis


Monday, March 08 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Monday, March 08 | 11:00AM - 1:00PM
Poster Setup
Room: Shavano/Torreys


Monday, March 08 | 1:00PM - 10:00PM
Poster Viewing
Room: Shavano/Torreys


Monday, March 08 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Longs Peak Foyer


Monday, March 08 | 5:00PM - 7:00PM
Cross Species Approach to Cardiac Development and Disease (J
oint)

Room: Grays/Longs

Speaker 1 of 5
* Jonathan G. Seidman, Harvard Medical School, USA

Monday, March 08 | 5:00PM - 7:00PM
Cross Species Approach to Cardiac Development and Disease (J
oint)

Room: Grays/Longs

Speaker 2 of 5
Eric N. Olson, University of Texas Southwestern Medical Center, USA
Transcriptional Regulation in Cardiac Development and Disease

Monday, March 08 | 5:00PM - 7:00PM
Cross Species Approach to Cardiac Development and Disease (J
oint)

Room: Grays/Longs

Speaker 3 of 5
* Deepak Srivastava, Gladstone Institutes, USA
Cardiac Developmental Genes: Implications for Childhood and Adult Disease

Monday, March 08 | 5:00PM - 7:00PM
Cross Species Approach to Cardiac Development and Disease (J
oint)

Room: Grays/Longs

Speaker 4 of 5
Christine E. Seidman, Harvard Medical School, USA
Deciphering Genetic Remodeling of the Human Heart in Zebrafish

Monday, March 08 | 5:00PM - 7:00PM
Cross Species Approach to Cardiac Development and Disease (J
oint)

Room: Grays/Longs

Speaker 5 of 5
Karl Ludwig Laugwitz, Technical University Munich, Germany
Short Talk: Identification, Renewal and Differentiation of Postnatal is l1+ Cardioblasts

Monday, March 08 | 7:00PM - 8:00PM
Social Hour
Room: Shavano/Torreys


Monday, March 08 | 7:30PM - 10:00PM
Poster Session 1
Room: Shavano/Torreys


Tuesday, March 09 | 7:00AM - 8:00AM
Breakfast
Room: Shavano/Torreys


Tuesday, March 09 | 8:00AM - 11:15AM
Electrophophysiologic Disorders
Room: Grays

Speaker 1 of 6
Kenneth R. Chien, Karolinska Institutet, Sweden
Cardiomyopathy, Conduction, and Cardioblasts: New Genetic Insights and Model Systems

Tuesday, March 09 | 8:00AM - 11:15AM
Electrophophysiologic Disorders
Room: Grays

Speaker 2 of 6
J. Kevin Donahue, Johns Hopkins University, USA
Gene Therapy for Cardiac Arrhythmias

Tuesday, March 09 | 8:00AM - 11:15AM
Electrophophysiologic Disorders
Room: Grays

Speaker 3 of 6
* Glenn I. Fishman, New York University School of Medicine, USA
Modeling the Conduction System

Tuesday, March 09 | 8:00AM - 11:15AM
Electrophophysiologic Disorders
Room: Grays

Speaker 4 of 6
D. Woodrow Benson, Cincinnati Children's Hospital, USA
Genetic Origins of Cardiac Arrhythmias in the Young

Tuesday, March 09 | 8:00AM - 11:15AM
Electrophophysiologic Disorders
Room: Grays

Speaker 5 of 6
Sameer S. Chopra, Vanderbilt University School of Medicine, USA
Short Talk: The Zebrafish as a Model for the Functional Analysis of Cardiac Sodium Channel alpha and beta Subunits

Tuesday, March 09 | 8:00AM - 11:15AM
Electrophophysiologic Disorders
Room: Grays

Speaker 6 of 6
Antoinette Groenewegen, Netherlands
Short Talk: Association of Human Connexin40 Gene Polymorphisms with Atrial Vulnerability for Initiation of Idiopathic Atrial Fibrillation

Tuesday, March 09 | 8:00AM - 11:00AM
Cardiac Patterning and Chamber Formation
This session is from Cardiac Development
Room: Longs Peak

Speaker 1 of 5
* Antoon F.M. Moorman, University of Amsterdam, Netherlands
Development of the Building Plan of the Heart


Tuesday, March 09 | 8:00AM - 11:00AM
Cardiac Patterning and Chamber Formation
This session is from Cardiac Development
Room: Longs Peak

Speaker 2 of 5
Didier Stainier, Max Planck Institute for Heart and Lung Research, Germany
Cardiovascular Development in Zebrafish


Tuesday, March 09 | 8:00AM - 11:00AM
Cardiac Patterning and Chamber Formation
This session is from Cardiac Development
Room: Longs Peak

Speaker 3 of 5
Margaret E. Buckingham, Institut Pasteur, France
The Origin of Myocardial Cells and their Oriented Cell Growth during Heart Morphogenesis


Tuesday, March 09 | 8:00AM - 11:00AM
Cardiac Patterning and Chamber Formation
This session is from Cardiac Development
Room: Longs Peak

Speaker 4 of 5
Jonathan A. Epstein, University of Pennsylvania, USA
The Homeodomain Only Protein, Hop, in Development, Hypertrophy and Heart Failure


Tuesday, March 09 | 8:00AM - 11:00AM
Cardiac Patterning and Chamber Formation
This session is from Cardiac Development
Room: Longs Peak

Speaker 5 of 5
Jose Luis de la Pompa, Centro Nacional de Investigaciones Cardiovasculares, Spain
Short Talk: Notch Promotes Epithelial-Mesenchymal Transition during Cardiac Development and Oncogenic Transformation


Tuesday, March 09 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Tuesday, March 09 | 11:00AM - 1:00PM
Poster Setup
Room: Shavano/Torreys


Tuesday, March 09 | 1:00PM - 10:00PM
Poster Viewing
Room: Shavano/Torreys


Tuesday, March 09 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Longs Peak Foyer


Tuesday, March 09 | 5:00PM - 7:00PM
Congenital Heart Disease/Genetics of Pediatric Heart Disease
(Joint)

Room: Grays/Longs

Speaker 1 of 5
* Christine E. Seidman, Harvard Medical School, USA

Tuesday, March 09 | 5:00PM - 7:00PM
Congenital Heart Disease/Genetics of Pediatric Heart Disease
(Joint)

Room: Grays/Longs

Speaker 2 of 5
Jeffrey A. Towbin, Cincinnati Children's Hospital Medical Center, USA
Genetics of Pediatric Cardiomyopathies and CHD

Tuesday, March 09 | 5:00PM - 7:00PM
Congenital Heart Disease/Genetics of Pediatric Heart Disease
(Joint)

Room: Grays/Longs

Speaker 3 of 5
Vidu Garg, Ohio State University/Nationwide Children's Hospital, USA
The Role of GATA4 in Congenital Heart Disease

Tuesday, March 09 | 5:00PM - 7:00PM
Congenital Heart Disease/Genetics of Pediatric Heart Disease
(Joint)

Room: Grays/Longs

Speaker 4 of 5
Cecilia W. Lo, University of Pittsburgh, USA
ENU Mutagenesis and Mouse Mutations Causing Congenital Heart Defects

Tuesday, March 09 | 5:00PM - 7:00PM
Congenital Heart Disease/Genetics of Pediatric Heart Disease
(Joint)

Room: Grays/Longs

Speaker 5 of 5
Jean-Jacques Schott, INSERM, France
Short Talk: Genetics of Valvular Diseases

Tuesday, March 09 | 7:00PM - 8:00PM
Social Hour
Room: Shavano/Torreys


Tuesday, March 09 | 7:30PM - 10:00PM
Poster Session 2
Room: Shavano/Torreys


Wednesday, March 10 | 7:00AM - 8:00AM
Breakfast
Room: Shavano/Torreys


Wednesday, March 10 | 8:00AM - 11:00AM
Cardiac Regeneration (Joint)
Room: Grays/Longs

Speaker 1 of 5
Michael D. Schneider, Imperial College London, UK
Cardiac Progenitor Cells from Adult Myocardium

Wednesday, March 10 | 8:00AM - 11:00AM
Cardiac Regeneration (Joint)
Room: Grays/Longs

Speaker 2 of 5
Bernardo Nadal-Ginard, New York Medical College, USA
Cardiac Stem Cells and Myocardial Regeneration

Wednesday, March 10 | 8:00AM - 11:00AM
Cardiac Regeneration (Joint)
Room: Grays/Longs

Speaker 3 of 5
* Nadia A. Rosenthal, The Jackson Laboratory, USA
Growth Factor Enhancement of Cardiac Regeneration

Wednesday, March 10 | 8:00AM - 11:00AM
Cardiac Regeneration (Joint)
Room: Grays/Longs

Speaker 4 of 5
Stefanie Dimmeler, University of Frankfurt, Germany
Circulating Progenitor Cells for Vasculogenesis and Cardiac Regeneration

Wednesday, March 10 | 8:00AM - 11:00AM
Cardiac Regeneration (Joint)
Room: Grays/Longs

Speaker 5 of 5
Ellen Heber-Katz, Lankenau Institute for Medical Research, USA
Short Talk: MRL Mouse Heart Healing Using Bone Marrow Chimeras Shows Host Dominance

Wednesday, March 10 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Wednesday, March 10 | 11:00AM - 1:00PM
Poster Setup
Room: Shavano/Torreys


Wednesday, March 10 | 1:00PM - 10:00PM
Poster Viewing
Room: Shavano/Torreys


Wednesday, March 10 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Longs Peak Foyer


Wednesday, March 10 | 5:00PM - 7:15PM
Signaling in Cardiac Remodeling
Room: Grays

Speaker 1 of 5
Richard T. Lee, Harvard University, USA
Mechanotransduction and Two Interesting Puzzles in Cardiomyopathy

Wednesday, March 10 | 5:00PM - 7:15PM
Signaling in Cardiac Remodeling
Room: Grays

Speaker 2 of 5
Rhonda Bassel-Duby, University of Texas Southwestern Medical Center, USA
Control of Muscle Growth and Remodeling by Calcium-Dependent Signaling

Wednesday, March 10 | 5:00PM - 7:15PM
Signaling in Cardiac Remodeling
Room: Grays

Speaker 3 of 5
* R. Sanders Williams, Duke University Medical Center, USA
Calcium Regulated Gene Transcription in Myocyte Remodeling

Wednesday, March 10 | 5:00PM - 7:15PM
Signaling in Cardiac Remodeling
Room: Grays

Speaker 4 of 5
Miei Shimura, Yokosuka City Hospital, Japan
Short Talk: Sarcalumenin, a Sarcoplasmic Reticulum Luminal Ca2+ Binding Protein Plays an Important Role in Maintaining Cardiac Function

Wednesday, March 10 | 5:00PM - 7:15PM
Signaling in Cardiac Remodeling
Room: Grays

Speaker 5 of 5
Jonathan A. Stiber, Duke University, USA
Short Talk: Homer Proteins Influence Muscle Remodeling Through the Calcineurin Signaling Pathway

Wednesday, March 10 | 5:00PM - 7:00PM
Pharyngeal Arch and Neural Crest Development
This session is from Cardiac Development
Room: Longs Peak

Speaker 1 of 4
Erik N. Meyers, Duke University Medical Center, USA
Fgf8 Signaling in Cardiovascular Development


Wednesday, March 10 | 5:00PM - 7:00PM
Pharyngeal Arch and Neural Crest Development
This session is from Cardiac Development
Room: Longs Peak

Speaker 2 of 4
Antonio Baldini, Institute of Genetics and Biophysics, Italy
Dissection of the Cardiovascular Phenotype in Mouse Models of DiGeorge Syndrome


Wednesday, March 10 | 5:00PM - 7:00PM
Pharyngeal Arch and Neural Crest Development
This session is from Cardiac Development
Room: Longs Peak

Speaker 3 of 4
* Margaret L. Kirby, Duke University Medical Center, USA
Collaboration of Cardiac Neural Crest and Caudal Pharynx is Needed for Patterning the Preseptation Arterial Pole


Wednesday, March 10 | 5:00PM - 7:00PM
Pharyngeal Arch and Neural Crest Development
This session is from Cardiac Development
Room: Longs Peak

Speaker 4 of 4
Aaron D. Gitler, Stanford University School of Medicine, USA
Short Talk: PlexinD1 is a Novel Endothelial-Specific Semaphorin Receptor Essential for Outflow Tract Septation and Aortic Arch Artery Patterning


Wednesday, March 10 | 7:00PM - 8:00PM
Social Hour
Room: Shavano/Torreys


Wednesday, March 10 | 7:30PM - 10:00PM
Poster Session 3
Room: Shavano/Torreys


Thursday, March 11 | 7:00AM - 8:00AM
Breakfast
Room: Shavano/Torreys


Thursday, March 11 | 8:00AM - 11:15AM
Pathways to Dilated Cardiomyopathy
Room: Grays

Speaker 1 of 6
* Andrew R. Marks, Columbia University College of Physicians and Surgeons, USA
A Unifying Principle Underlying Cardiac Arrhythmias and Heart Failure

Thursday, March 11 | 8:00AM - 11:15AM
Pathways to Dilated Cardiomyopathy
Room: Grays

Speaker 2 of 6
Luisa Mestroni, University of Colorado Denver-AMC, USA
Genotype/Phenotype Correlations in Dilated Cardiomyopathy

Thursday, March 11 | 8:00AM - 11:15AM
Pathways to Dilated Cardiomyopathy
Room: Grays

Speaker 3 of 6
Kevin P. Campbell, University of Iowa, USA
Dystroglycan, Dysferlin and Cardiomyopathy

Thursday, March 11 | 8:00AM - 11:15AM
Pathways to Dilated Cardiomyopathy
Room: Grays

Speaker 4 of 6
Elizabeth M. McNally, Northwestern University, USA
Genetic Diversity in Cardiomyopathy

Thursday, March 11 | 8:00AM - 11:15AM
Pathways to Dilated Cardiomyopathy
Room: Grays

Speaker 5 of 6
David H. MacLennan, Canada
Short Talk: Identification of Biochemical Adaptations in Hyper- or Hypocontractile Hearts from Phospholamban Mutant Mice by Expression Proteomics

Thursday, March 11 | 8:00AM - 11:15AM
Pathways to Dilated Cardiomyopathy
Room: Grays

Speaker 6 of 6
Charles Redwood, University of Oxford, UK
Short Talk: Dilated Cardiomyopathy-Causing Mutations in Troponin T, Troponin C and alpha-Tropomyosin Reduce Ca2+-Sensitivity and Maximum Activation

Thursday, March 11 | 8:00AM - 11:00AM
Signaling Pathways in Cardiac Development
This session is from Cardiac Development
Room: Longs Peak

Speaker 1 of 5
Rolf Bodmer, Sanford-Burnham Medical Research Institute, USA
Genetic Control of Cardiac Development and Aging


Thursday, March 11 | 8:00AM - 11:00AM
Signaling Pathways in Cardiac Development
This session is from Cardiac Development
Room: Longs Peak

Speaker 2 of 5
* H. Joseph Joseph Yost, University of Utah, USA
Cell Signaling in Cardiac Left-Right Development


Thursday, March 11 | 8:00AM - 11:00AM
Signaling Pathways in Cardiac Development
This session is from Cardiac Development
Room: Longs Peak

Speaker 3 of 5
Martina Brueckner, Yale University School of Medicine, USA
Cilia are at the Heart of the Development of Left-Right Asymmetry


Thursday, March 11 | 8:00AM - 11:00AM
Signaling Pathways in Cardiac Development
This session is from Cardiac Development
Room: Longs Peak

Speaker 4 of 5
Tom Gridley, The Jackson Laboratory, USA
Notch Signaling in Cardiovascular Development and Disease


Thursday, March 11 | 8:00AM - 11:00AM
Signaling Pathways in Cardiac Development
This session is from Cardiac Development
Room: Longs Peak

Speaker 5 of 5
Deborah L. Yelon, University of California, San Diego, USA
Short Talk: Retinoic Acid Signaling Restricts the Cardiac Progenitor Pool


Thursday, March 11 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Thursday, March 11 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Longs Peak Foyer


Thursday, March 11 | 5:00PM - 7:15PM
Models of Human Heart Disease
Room: Grays

Speaker 1 of 4
Harry (Hal) C. Dietz, Johns Hopkins University School of Medicine, Blade Therapeutics, USA
Novel Insights into Pathogenesis and Therapy of Marfan Syndrome

Thursday, March 11 | 5:00PM - 7:15PM
Models of Human Heart Disease
Room: Grays

Speaker 2 of 4
Craig T. Basson, Weill Medical College of Cornell University, USA
Molecular Genetic Mechanisms Underlying PKA-Dependent Cardiac Tumorigenesis

Thursday, March 11 | 5:00PM - 7:15PM
Models of Human Heart Disease
Room: Grays

Speaker 3 of 4
* Jeffrey Robbins, Cincinnati Children's Hospital Medical Center, USA
The Desmin-Related Cardiomyopathies: Form and Function

Thursday, March 11 | 5:00PM - 7:15PM
Models of Human Heart Disease
Room: Grays

Speaker 4 of 4
Mark T. Keating, Novartis Institutes for BioMedical Research, USA
Cardiac Regeneration

Thursday, March 11 | 5:00PM - 7:00PM
Transcriptional Circuits in Cardiomyocyte Development
This session is from Cardiac Development
Room: Longs Peak

Speaker 1 of 3
* Robert J. Schwartz, Texas A&M University, USA
Serum Response Factor a Master Cardiogenic Regulatory Platform and a Novel Phosphorylatable Gene Switch Target


Thursday, March 11 | 5:00PM - 7:00PM
Transcriptional Circuits in Cardiomyocyte Development
This session is from Cardiac Development
Room: Longs Peak

Speaker 2 of 3
William T. Pu, Children's Hospital, Harvard Medical School, USA
Regulation of Heart Development by GATA4: Distinct Functional Requirements in the Endocardium and Myocardium


Thursday, March 11 | 5:00PM - 7:00PM
Transcriptional Circuits in Cardiomyocyte Development
This session is from Cardiac Development
Room: Longs Peak

Speaker 3 of 3
Robert A. Schulz, University of Texas MD Anderson Cancer Center, USA
Transcriptional Control of Heart Morphogenesis in Drosophila


Thursday, March 11 | 7:00PM - 8:00PM
Social Hour
Room: Quandary Peak


Thursday, March 11 | 8:00PM - 11:00PM
Entertainment
Room: Quandary Peak


Thursday, March 11 | 8:00PM - 11:00PM
Cash Bar
Room: Quandary Peak


Friday, March 12 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.