Web Desc
Molecular Mechanisms of HIV Pathogenesis
joint with HIV Vaccine Development: Progress and Prospects
Organizer(s): Beatrice H. Hahn, Wesley I. Sundquist, Michael H. Malim and Didier Trono
Date: April 12 - 18, 2004
Location: Whistler Conference Centre, Whistler, BC, Canada
Supported by Keystone Symposia
Summary of Meeting:
To replicate and cause disease, HIV-1 must overcome cellular and humoral immune responses, defeat innate cellular defense systems, usurp cellular factors, and reprogram the normal biology of the cell. Historically, detailed genetic analyses of viral functions and evolution have identified key viral determinants for the successful completion of each stage in the replication cycle. More recently, studies of innate antiviral and immune responses, host genetics, cell biology, and neuropathogenesis have identified host factors that HIV-1 must overcome in order to replicate. The field is now poised to combine these studies to define the molecular mechanisms that underlie important host/virus interactions, and our meeting therefore focuses on emerging concepts in the molecular mechanisms of HIV pathogenesis. Significant recent advances in this area include: the definition of a variety of envelope/receptor interactions, the development of tools for depleting cellular proteins and visualizing viral trafficking in real time, the discovery of cellular factors and genetic elements that restrict viral replication, an increased understanding of the activities of pathogenesis factors such as nef, the identification of host factors required for viral replication, assembly and budding, the development of non-pathogenic primate lentiviral models, and an increased understanding of the origins and evolution of HIV and primate lentiviruses in general. This recent progress opens the way to answering new questions: - How does the virus penetrate its target cells, once the envelope binds its receptors and undergoes an increasingly well characterized number of structural modifications? - What is the site and mechanism of uncoating, the step through which the inner components of viral cores lose their external layer, the capsid, and organize into an enzymatically active nucleoprotein complex? - How does the virus escape what increasingly appears to be a formidable attempt of the cell to repel this genetic invader? - How does the viral genome find its way to regions of the chromosome in which it is almost always successfully expressed? - How does the combination of host and viral factors modulate viral transcription and cell division, seemingly adapting it to the extracellular environment, and in some rare but critical cells resulting in latent, reactivatable gene expression? - How does the virus hijack intracellular machineries to organize the formation of new particles and promote their release from the infected cell? - What cells host the long-term reservoir of HIV that seems to preclude viral eradication in patients treated with highly active chemotherapy? - How do these cells avoid elimination by the immune system? - Why are naturally occurring SIV infections not causing disease in their natural hosts? - How can we best utilize these SIVs as tools to probe the pathogenic mechanisms of HIV? By bringing together a group of international leaders in HIV/AIDS research, new and exciting information in all of these areas will be presented, new paradigms will be established, and, perhaps, new approaches for anti-HIV therapeutics will be identified.
We gratefully acknowledge additional support for this conference from:

Bentham Science Publishers Ltd.
Bill & Melinda Gates FoundationBoehringer Ingelheim (Canada) Ltd.Office of AIDS Research, NIH
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI058790-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Monday, April 12 | 3:00PM - 7:00PM
Registration
Room: Grand Foyer


Monday, April 12 | 6:15PM - 7:15PM
Refreshments
Room: Grand Foyer


Monday, April 12 | 7:15PM - 7:30PM
Orientation
Room: Ballroom B, C


Monday, April 12 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Ballroom B, C

Speaker 1 of 3
* Norman L. Letvin, Beth Israel Deaconess Medical Center, USA

Monday, April 12 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Ballroom B, C

Speaker 2 of 3
Gary J. Nabel, Sanofi, USA
The Critical Path to an Effective AIDS Vaccine

Monday, April 12 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Ballroom B, C

Speaker 3 of 3
Wesley I. Sundquist, University of Utah School of Medicine, USA
The Biochemistry of HIV-1 Release

Tuesday, April 13 | 6:30AM - 8:00AM
Breakfast
Room: Lower Level


Tuesday, April 13 | 8:00AM - 11:00AM
HIV Entry Mechanisms and Neutralizing Antibodies (Joint)
Room: Ballroom B, C

Speaker 1 of 6
* Joseph G. Sodroski, Dana-Farber Cancer Institute, USA
Innate Intracellular Immunity to HIV-1 in Old World Monkeys

Tuesday, April 13 | 8:00AM - 11:00AM
HIV Entry Mechanisms and Neutralizing Antibodies (Joint)
Room: Ballroom B, C

Speaker 2 of 6
David C. Montefiori, Duke University Medical Center, USA
Neutralizing Antibodies Induced by Candidate HIV-1 Vaccines

Tuesday, April 13 | 8:00AM - 11:00AM
HIV Entry Mechanisms and Neutralizing Antibodies (Joint)
Room: Ballroom B, C

Speaker 3 of 6
Alexandra Trkola, University of Zürich, Switzerland
Antibodies: Surrogate or Supporter of Protective Immunity?

Tuesday, April 13 | 8:00AM - 11:00AM
HIV Entry Mechanisms and Neutralizing Antibodies (Joint)
Room: Ballroom B, C

Speaker 4 of 6
Susan Zolla-Pazner, Icahn School of Medicine at Mount Sinai, USA
The V3 Loop: Always Changing, Always the Same

Tuesday, April 13 | 8:00AM - 11:00AM
HIV Entry Mechanisms and Neutralizing Antibodies (Joint)
Room: Ballroom B, C

Speaker 5 of 6
Gregory B. Melikian, Emory University, USA
Short Talk: Dissecting the Steps of HIV ENV-Induced Fusion: Coreceptor Engagement, Fusion Pore Formation, and Pore Enlargement

Tuesday, April 13 | 8:00AM - 11:00AM
HIV Entry Mechanisms and Neutralizing Antibodies (Joint)
Room: Ballroom B, C

Speaker 6 of 6
James Mark Binley, San Diego Biomedical Research Institute, USA
Short Talk: Comprehensive Cross-Clade Neutralization Analysis of a Panel of Anti-HIV Monoclonal Antibodies and a Clade B HIV+ Plasma

Tuesday, April 13 | 9:20AM - 9:40AM
Coffee Break
Room: Grand Foyer


Tuesday, April 13 | 11:00AM - 1:00PM
Poster Setup
Room: Ballroom A, Grand Foyer


Tuesday, April 13 | 1:00PM - 10:00PM
Poster Viewing
Room: Ballroom A, Grand Foyer


Tuesday, April 13 | 2:00PM - 4:00PM
Workshop 1: HIV Accessory Protein and Assembly
Room: Garibaldi A/B
Attendance Limited to 125
Speaker 1 of 9
* Wesley I. Sundquist, University of Utah School of Medicine, USA
Following the RNA

Tuesday, April 13 | 2:00PM - 4:00PM
Workshop 1: HIV Accessory Protein and Assembly
Room: Garibaldi A/B
Attendance Limited to 125
Speaker 2 of 9
Melanie M. Ott, Gladstone Institutes, USA
SIRT1 Deacetylates the HIV Tat Protein and is Required for Tat-Mediated Transactivation of the HIV Promoter

Tuesday, April 13 | 2:00PM - 4:00PM
Workshop 1: HIV Accessory Protein and Assembly
Room: Garibaldi A/B
Attendance Limited to 125
Speaker 3 of 9
Roger J. Pomerantz, Seres Therapeutics, Inc., USA
A Dead Box Protein is as a Critical Cellular Co-Factor of HIV-1 REV: Effects on Viral Persistence and Reservoirs in Different Cell-Types

Tuesday, April 13 | 2:00PM - 4:00PM
Workshop 1: HIV Accessory Protein and Assembly
Room: Garibaldi A/B
Attendance Limited to 125
Speaker 4 of 9
Chad M. Swanson, King's College London, UK
A Link between Viral Assembly and Nuclear Export

Tuesday, April 13 | 2:00PM - 4:00PM
Workshop 1: HIV Accessory Protein and Assembly
Room: Garibaldi A/B
Attendance Limited to 125
Speaker 5 of 9
Andrew J. Mouland, McGill University, Lady Davis Institute, Canada
The Specific Association of hnRNP A2 to its Cognate Response Sequence in HIV-1 RNA Implications in Viral Assembly

Tuesday, April 13 | 2:00PM - 4:00PM
Workshop 1: HIV Accessory Protein and Assembly
Room: Garibaldi A/B
Attendance Limited to 125
Speaker 6 of 9
Heinrich Göttlinger, Dana Farber Cancer Institute, USA
Roles of AIP1 and ESCRT-III in HIV Budding

Tuesday, April 13 | 2:00PM - 4:00PM
Workshop 1: HIV Accessory Protein and Assembly
Room: Garibaldi A/B
Attendance Limited to 125
Speaker 7 of 9
Marc C. Johnson, Cornell University, USA
Visual Comparison of Retroviral Late-Domain Phenotypes

Tuesday, April 13 | 2:00PM - 4:00PM
Workshop 1: HIV Accessory Protein and Assembly
Room: Garibaldi A/B
Attendance Limited to 125
Speaker 8 of 9
Rebecca J. Loomis, University of North Carolina at Chapel Hill, USA
Citron Kinase, a RhoA Effector, Enhances HIV-1 Virion Release

Tuesday, April 13 | 2:00PM - 4:00PM
Workshop 1: HIV Accessory Protein and Assembly
Room: Garibaldi A/B
Attendance Limited to 125
Speaker 9 of 9
Vicente Planelles, University of Utah, USA
The Mechanisms of HIV-1 VPR-Mediated G2 Arrest and Apoptosis: Role of the Host Cell DNA Damage Signaling Pathway

Tuesday, April 13 | 2:00PM - 4:15PM
Workshop 1: HIV Envelope Structure and Neutralization
This session is from HIV Vaccine
Room: Ballroom B, C

Speaker 1 of 10
* Richard T. Wyatt, IAVI Neutralizing Antibody Center, The Scripps Research Institute, USA


Tuesday, April 13 | 2:00PM - 4:15PM
Workshop 1: HIV Envelope Structure and Neutralization
This session is from HIV Vaccine
Room: Ballroom B, C

Speaker 2 of 10
Barna Dey, NIAID, National Institutes of Health, USA
Characterization of Mutant HIV-1 Envelope Glycoproteins Stabilized in the CD4-Bound Conformation


Tuesday, April 13 | 2:00PM - 4:15PM
Workshop 1: HIV Envelope Structure and Neutralization
This session is from HIV Vaccine
Room: Ballroom B, C

Speaker 3 of 10
Kathy P. Fernando, University of Pennsylvania, USA
HIV Env Lacking CD4 Binding as a Vaccine Approach


Tuesday, April 13 | 2:00PM - 4:15PM
Workshop 1: HIV Envelope Structure and Neutralization
This session is from HIV Vaccine
Room: Ballroom B, C

Speaker 4 of 10
Marie Pancera, Fred Hutchinson Cancer Research Center, USA
Characterization of Stabilized Trimeric HIV-1 gp120 Envelope Glycoprotein


Tuesday, April 13 | 2:00PM - 4:15PM
Workshop 1: HIV Envelope Structure and Neutralization
This session is from HIV Vaccine
Room: Ballroom B, C

Speaker 5 of 10
Suganya Selvarajah, The Scripps Research Institute, USA
Modified gp140 Trimers to Elicit b12-Like Antibodies


Tuesday, April 13 | 2:00PM - 4:15PM
Workshop 1: HIV Envelope Structure and Neutralization
This session is from HIV Vaccine
Room: Ballroom B, C

Speaker 6 of 10
Chinglai Yang, Emory University, USA
Characterization of an HA/Gp41 Chimeric Protein: Enhanced Interaction with the Broadly Neutralizing Monoclonal Antibody 2F5 against HIV


Tuesday, April 13 | 2:00PM - 4:15PM
Workshop 1: HIV Envelope Structure and Neutralization
This session is from HIV Vaccine
Room: Ballroom B, C

Speaker 7 of 10
Jason E. Hammonds, Emory University, USA
Induction of Antibody Responses to CD4-Induced Epitopes by Induced Pseudovirions and Recombinant Protein Immunogens


Tuesday, April 13 | 2:00PM - 4:15PM
Workshop 1: HIV Envelope Structure and Neutralization
This session is from HIV Vaccine
Room: Ballroom B, C

Speaker 8 of 10
Jonathan M. Gershoni, Tel Aviv University, Israel
Backtracking from mAb to Epitope - A Combinatorial Approach


Tuesday, April 13 | 2:00PM - 4:15PM
Workshop 1: HIV Envelope Structure and Neutralization
This session is from HIV Vaccine
Room: Ballroom B, C

Speaker 9 of 10
Carolina Herrera, Imperial College, UK
Consequences of HIV-1 Env Cleavage on Antigenicity, Infectivity, and Neutralization


Tuesday, April 13 | 2:00PM - 4:15PM
Workshop 1: HIV Envelope Structure and Neutralization
This session is from HIV Vaccine
Room: Ballroom B, C

Speaker 10 of 10
Gerald V. Quinnan, Jr., Uniformed Services University Health Sciences, USA
Protection Against Rhesus Monkey Adapted-SHIV Challenge by Active Induction of HIV-1 Neutralizing Antibodies or SIV gag-Specific Cytotoxic T Cells


Tuesday, April 13 | 4:30PM - 4:45PM
Coffee & Snacks Available
Room: Grand Foyer


Tuesday, April 13 | 4:45PM - 7:00PM
Natural SIV Infection: Lessons from the Monkey (Joint)
Room: Ballroom B, C

Speaker 1 of 5
* Paul M. Sharp, University of Edinburgh, UK
Evolution from SIV to HIV

Tuesday, April 13 | 4:45PM - 7:00PM
Natural SIV Infection: Lessons from the Monkey (Joint)
Room: Ballroom B, C

Speaker 2 of 5
Beatrice H. Hahn, University of Pennsylvania, USA
Molecular Epidemiology of Simian Immunodeficiency Virus Infection in Wild Chimpanzees

Tuesday, April 13 | 4:45PM - 7:00PM
Natural SIV Infection: Lessons from the Monkey (Joint)
Room: Ballroom B, C

Speaker 3 of 5
Mark B. Feinberg, IAVI International AIDS Vaccine Initiative, USA
Host-Virus Relationships Underlying Non-Pathogenic SIV Infections


Tuesday, April 13 | 4:45PM - 7:00PM
Natural SIV Infection: Lessons from the Monkey (Joint)
Room: Ballroom B, C

Speaker 4 of 5
Greg J. Towers, University College London, UK
Short Talk: Species-Specific Infection of Lentiviruses

Tuesday, April 13 | 4:45PM - 7:00PM
Natural SIV Infection: Lessons from the Monkey (Joint)
Room: Ballroom B, C

Speaker 5 of 5
Nathaniel R. Landau, New York University School of Medicine, USA
Short Talk: Mechanism of APOBEC3G Deamination of HIV Reverse Transcripts

Tuesday, April 13 | 7:00PM - 8:00PM
Social Hour
Room: Ballroom A, Grand Foyer


Tuesday, April 13 | 7:30PM - 10:00PM
Poster Session 1
Room: Ballroom A, Grand Foyer


Wednesday, April 14 | 6:30AM - 8:00AM
Breakfast
Room: Lower Level


Wednesday, April 14 | 8:00AM - 11:00AM
HIV Genome RNA: From the Nucleus to the Plasma Membrane
Room: Ballroom C

Speaker 1 of 5
* Tristram G. Parslow, Emory University, USA
The HIV-1 Genomic Dimer Interface as a Target for Structure-Based Drug Design

Wednesday, April 14 | 8:00AM - 11:00AM
HIV Genome RNA: From the Nucleus to the Plasma Membrane
Room: Ballroom C

Speaker 2 of 5
Kathleen A. Boris-Lawrie, Ohio State University, USA
The Destiny of Retroviral Unspliced RNA: Ribosome or Virion?

Wednesday, April 14 | 8:00AM - 11:00AM
HIV Genome RNA: From the Nucleus to the Plasma Membrane
Room: Ballroom C

Speaker 3 of 5
Casey D. Morrow, University of Alabama at Birmingham, USA
Selection of the tRNA Primer required for HIV Replication


Wednesday, April 14 | 8:00AM - 11:00AM
HIV Genome RNA: From the Nucleus to the Plasma Membrane
Room: Ballroom C

Speaker 4 of 5
Chantal Ehresmann, IBMC du Centre National de la Recherche Scientifique, France
The 5' -Untranslated Region of HIV-1 Genomic RNA: Structure and Functional Implications

Wednesday, April 14 | 8:00AM - 11:00AM
HIV Genome RNA: From the Nucleus to the Plasma Membrane
Room: Ballroom C

Speaker 5 of 5
James R. Williamson, The Scripps Research Institute, USA
Toward Inhibition of HIV Rev-RRE Interactions: Challenges for Targeting RNA

Wednesday, April 14 | 8:00AM - 9:30AM
Current Issues in the Clinical Evaluation of Vaccines
This session is from HIV Vaccine
Room: Ballroom B

Speaker 1 of 3
John W. Shiver, Sanofi Pasteur, USA
Development of an HIV-1 Vaccine Based on Replication-Defective Adenovirus


Wednesday, April 14 | 8:00AM - 9:30AM
Current Issues in the Clinical Evaluation of Vaccines
This session is from HIV Vaccine
Room: Ballroom B

Speaker 2 of 3
* Barney S. Graham, NIAID, National Institutes of Health, USA
Update of Trials of Multi-Clade DNA and Recombinant Adenovirus Vaccines


Wednesday, April 14 | 8:00AM - 9:30AM
Current Issues in the Clinical Evaluation of Vaccines
This session is from HIV Vaccine
Room: Ballroom B

Speaker 3 of 3
Lawrence Corey, Fred Hutchinson Cancer Research Center, USA
Update of HVTN Clinical Trials


Wednesday, April 14 | 9:20AM - 9:40AM
Coffee Break
Room: Grand Foyer


Wednesday, April 14 | 9:50AM - 11:30AM
Roundtable Discussion: Immunogenicity Criteria for Advancing
Candidate Vaccines into Phase III Trials
This session is from HIV Vaccine
Room: Ballroom B

Speaker 1 of 8
* Gary J. Nabel, Sanofi, USA


Wednesday, April 14 | 9:50AM - 11:30AM
Roundtable Discussion: Immunogenicity Criteria for Advancing
Candidate Vaccines into Phase III Trials
This session is from HIV Vaccine
Room: Ballroom B

Speaker 2 of 8
Dennis R. Burton, The Scripps Research Institute, USA
Criteria for Neutralizing Antibody Responses


Wednesday, April 14 | 9:50AM - 11:30AM
Roundtable Discussion: Immunogenicity Criteria for Advancing
Candidate Vaccines into Phase III Trials
This session is from HIV Vaccine
Room: Ballroom B

Speaker 3 of 8
Hana Golding, US Food and Drug Administration, USA
Regulatory Perspective


Wednesday, April 14 | 9:50AM - 11:30AM
Roundtable Discussion: Immunogenicity Criteria for Advancing
Candidate Vaccines into Phase III Trials
This session is from HIV Vaccine
Room: Ballroom B

Speaker 4 of 8
Emilio A. Emini, Bill and Melinda Gates Foundation, USA
Manufacturer's Perspective


Wednesday, April 14 | 9:50AM - 11:30AM
Roundtable Discussion: Immunogenicity Criteria for Advancing
Candidate Vaccines into Phase III Trials
This session is from HIV Vaccine
Room: Ballroom B

Speaker 5 of 8
John G. McNeil, Sanofi-Pasteur, USA
Clinical Perspective


Wednesday, April 14 | 9:50AM - 11:30AM
Roundtable Discussion: Immunogenicity Criteria for Advancing
Candidate Vaccines into Phase III Trials
This session is from HIV Vaccine
Room: Ballroom B

Speaker 6 of 8
Steve G. Self, Fred Hutchinson Cancer Research Center, USA
Statistical Perspective


Wednesday, April 14 | 9:50AM - 11:30AM
Roundtable Discussion: Immunogenicity Criteria for Advancing
Candidate Vaccines into Phase III Trials
This session is from HIV Vaccine
Room: Ballroom B

Speaker 7 of 8
Andrew J. McMichael, Oxford University, UK
Criteria for T Cell Responses


Wednesday, April 14 | 9:50AM - 11:30AM
Roundtable Discussion: Immunogenicity Criteria for Advancing
Candidate Vaccines into Phase III Trials
This session is from HIV Vaccine
Room: Ballroom B

Speaker 8 of 8
John P. Moore, Weill Medical College of Cornell University, USA
Criteria for Neutralizing Antibody Responses


Wednesday, April 14 | 11:00AM - 1:00PM
Poster Setup
Room: Ballroom A, Grand Foyer


Wednesday, April 14 | 1:00PM - 10:00PM
Poster Viewing
Room: Ballroom A, Grand Foyer


Wednesday, April 14 | 2:00PM - 4:00PM
Workshop 2: The Viral Synapse
Room: Ballroom C

Speaker 1 of 9
* Michael H. Malim, King's College London, UK

Wednesday, April 14 | 2:00PM - 4:00PM
Workshop 2: The Viral Synapse
Room: Ballroom C

Speaker 2 of 9
Vincent Piguet, Cardiff University, UK
DC-SIGN-Mediated Infectious Synapse Formation Enhances Transfer of HIV Infection from Dendritic Cells to T Cells

Wednesday, April 14 | 2:00PM - 4:00PM
Workshop 2: The Viral Synapse
Room: Ballroom C

Speaker 3 of 9
Clare Jolly, University College London, UK
HIV-1 Exploits an Env-Induced Synapse in CD4+ T Cells

Wednesday, April 14 | 2:00PM - 4:00PM
Workshop 2: The Viral Synapse
Room: Ballroom C

Speaker 4 of 9
Philippe Gallay, The Scripps Research Institute, USA
A Highly Conserved Arginine in the V3 Loop of Gp120 Governs HIV-1 Binding to Coreceptors and Syndecans

Wednesday, April 14 | 2:00PM - 4:00PM
Workshop 2: The Viral Synapse
Room: Ballroom C

Speaker 5 of 9
Teunis B.H. Geijtenbeek, University of Amsterdam, Netherlands
Mechanisms of DC-Sign Mediated Function in HIV-1 Infection

Wednesday, April 14 | 2:00PM - 4:00PM
Workshop 2: The Viral Synapse
Room: Ballroom C

Speaker 6 of 9
Rahm Gummuluru, Boston University School of Medicine, USA
Mechanism of DC-SIGN Mediated HIV-1 Transmission

Wednesday, April 14 | 2:00PM - 4:00PM
Workshop 2: The Viral Synapse
Room: Ballroom C

Speaker 7 of 9
David McDonald, National Institute of Allergy and Infectious Disease, USA
Enhancement of HIV Infection by Activated Dendritic Cells Occurs via
Trafficking through a CD81 Enriched Compartment


Wednesday, April 14 | 2:00PM - 4:00PM
Workshop 2: The Viral Synapse
Room: Ballroom C

Speaker 8 of 9
Ann-Marie M. Roy, University of California, San Francisco, USA
Impact of Coreceptor Use on HIV-1 Viral Output per Infected Cell

Wednesday, April 14 | 2:00PM - 4:00PM
Workshop 2: The Viral Synapse
Room: Ballroom C

Speaker 9 of 9
John Wilkinson, Westmead Millennium Institute, Australia
Increased HIV-1 Uptake in Immature Dendritic Cells and Increased Viral Transfer to CD4+ T Cells as a Result of Inhibition of the Endosomal - Lysosomal Degradation Pathway

Wednesday, April 14 | 2:00PM - 4:00PM
Workshop 2: Immunobiology of HIV Infection
This session is from HIV Vaccine
Room: Ballroom B

Speaker 1 of 7
* Luis J. Montaner, Wistar Institute, USA


Wednesday, April 14 | 2:00PM - 4:00PM
Workshop 2: Immunobiology of HIV Infection
This session is from HIV Vaccine
Room: Ballroom B

Speaker 2 of 7
David Favre, GlaxoSmithKline, USA
Generation of Dysfunctional CD8+ T Cells in the Setting of HIV Infection


Wednesday, April 14 | 2:00PM - 4:00PM
Workshop 2: Immunobiology of HIV Infection
This session is from HIV Vaccine
Room: Ballroom B

Speaker 3 of 7
Daniel E. Kaufmann, University of Montreal, Canada
Promiscuous Presentation of the Same Epitopes by Different HLA Class II Alleles and Clustering of Overlapping Epitopes both Contribute to the High Frequency of Recognition by CD4 Cells of a Limited Subset of Gag and Nef HIV-1 Peptides


Wednesday, April 14 | 2:00PM - 4:00PM
Workshop 2: Immunobiology of HIV Infection
This session is from HIV Vaccine
Room: Ballroom B

Speaker 4 of 7
Christian Brander, Institut de Recerca de la Sida, IrsiCaixa, Spain
HLA-B63 (B*1516/B*1517) Presents HLA-B57 Restricted CTL Epitopes and is Associated with Slow HIV Disease Progression


Wednesday, April 14 | 2:00PM - 4:00PM
Workshop 2: Immunobiology of HIV Infection
This session is from HIV Vaccine
Room: Ballroom B

Speaker 5 of 7
Marie-Claire E. Gauduin, Texas Biomedical Research Institute, USA
Depletion of CD8+ Lymphocytes Results in Rebound Viremia in SIV-Infected Macaques with Undetectable Viral Replication following Early Antiretroviral Therapy


Wednesday, April 14 | 2:00PM - 4:00PM
Workshop 2: Immunobiology of HIV Infection
This session is from HIV Vaccine
Room: Ballroom B

Speaker 6 of 7
David A. Garber, Emory University, USA
Enhancing the Immunogenicity of MVA-based AIDS Vaccines


Wednesday, April 14 | 2:00PM - 4:00PM
Workshop 2: Immunobiology of HIV Infection
This session is from HIV Vaccine
Room: Ballroom B

Speaker 7 of 7
Shan Lu, University of Massachusetts Medical Center, USA
Immunogenicity of Monovalent and Polyvalent DNA Prime/Protein Boost Formulations Encoding Primary HIV-1 Env Antigens as Tested in Rabbits and Non-Human Primate Models


Wednesday, April 14 | 4:30PM - 4:45PM
Coffee & Snacks Available
Room: Grand Foyer


Wednesday, April 14 | 4:45PM - 7:15PM
Immediate Early Steps in Viral Entry and Uncoating
Room: Ballroom C

Speaker 1 of 5
* John P. Moore, Weill Medical College of Cornell University, USA
Effect of a Small Molecule CCR5 Inhibitor on Virus Infection in the Rhesus Macaque

Wednesday, April 14 | 4:45PM - 7:15PM
Immediate Early Steps in Viral Entry and Uncoating
Room: Ballroom C

Speaker 2 of 5
John A. T. Young, F.Hoffmann-La Roche Ltd, Switzerland
Cellular Factor Requirement in HIV-1 Uncoating Revealed by a Cell-Free System

Wednesday, April 14 | 4:45PM - 7:15PM
Immediate Early Steps in Viral Entry and Uncoating
Room: Ballroom C

Speaker 3 of 5
Christopher Aiken, Vanderbilt University School of Medicine, USA
Capsid Disassembly and HIV-1 Infection

Wednesday, April 14 | 4:45PM - 7:15PM
Immediate Early Steps in Viral Entry and Uncoating
Room: Ballroom C

Speaker 4 of 5
Thomas J. Hope, Northwestern University, USA
HIV Entry and Early Events (Cytoplasmic Trafficking)

Wednesday, April 14 | 4:45PM - 7:15PM
Immediate Early Steps in Viral Entry and Uncoating
Room: Ballroom C

Speaker 5 of 5
Vineet N. KewalRamani, NCI, National Institutes of Health, USA
Cell and Molecular Requirements for DC-SIGN-Mediated HIV Transmission

Wednesday, April 14 | 4:45PM - 7:00PM
Advances in Immunobiology
This session is from HIV Vaccine
Room: Ballroom B

Speaker 1 of 4
Arlene H. Sharpe, Harvard Medical School, USA
Current Understanding of Immune Co-Stimulation


Wednesday, April 14 | 4:45PM - 7:00PM
Advances in Immunobiology
This session is from HIV Vaccine
Room: Ballroom B

Speaker 2 of 4
* Antonio Lanzavecchia, Institute for Research in Biomedicine, Switzerland
Induction and Maintenance of Serological Memory


Wednesday, April 14 | 4:45PM - 7:00PM
Advances in Immunobiology
This session is from HIV Vaccine
Room: Ballroom B

Speaker 3 of 4
Jonathan W. Yewdell, NIAID, National Institutes of Health, USA
Induction of TCD8+ Responses by Viruses


Wednesday, April 14 | 4:45PM - 7:00PM
Advances in Immunobiology
This session is from HIV Vaccine
Room: Ballroom B

Speaker 4 of 4
Eli Gilboa, University of Miami, Miller School of Medicine, USA
Therapeutic Vaccination with mRNA Transfected Dendritic Cells for Cancer and Infectious Diseases


Wednesday, April 14 | 7:00PM - 8:00PM
Social Hour
Room: Ballroom A, Grand Foyer


Wednesday, April 14 | 7:30PM - 10:00PM
Poster Session 2
Room: Ballroom A, Grand Foyer


Thursday, April 15 | 6:30AM - 8:00AM
Breakfast
Room: Lower Level


Thursday, April 15 | 8:00AM - 11:30AM
Innate Intracellular Antiviral Responses (Joint)
Room: Ballroom B, C

Speaker 1 of 6
Michael H. Malim, King's College London, UK
VIF and the Evasion of Host-Mediated Viral cDNA Deamination

Thursday, April 15 | 8:00AM - 11:30AM
Innate Intracellular Antiviral Responses (Joint)
Room: Ballroom B, C

Speaker 2 of 6
Warner Craig Greene, Gladstone Institute of Virology and Immunology, USA
HIV Vif versus the Antiviral APOBEC3G Enzyme: New Insights into the Mechanism of Vif Action

Thursday, April 15 | 8:00AM - 11:30AM
Innate Intracellular Antiviral Responses (Joint)
Room: Ballroom B, C

Speaker 3 of 6
Didier Trono, Ecole Polytechnique Fédérale de Lausanne, Switzerland
Innate Intracellular defenses Against Retroelements


Thursday, April 15 | 8:00AM - 11:30AM
Innate Intracellular Antiviral Responses (Joint)
Room: Ballroom B, C

Speaker 4 of 6
* Stephen P. Goff, Columbia University, USA
Cellular Blocks to HIV and MuLV Infection

Thursday, April 15 | 8:00AM - 11:30AM
Innate Intracellular Antiviral Responses (Joint)
Room: Ballroom B, C

Speaker 5 of 6
Jonathan P. Stoye, Francis Crick Institute, UK
Fv1 and Related Retrovirus Restriction Genes

Thursday, April 15 | 8:00AM - 11:30AM
Innate Intracellular Antiviral Responses (Joint)
Room: Ballroom B, C

Speaker 6 of 6
Jaisri R. Lingappa, University of Washington, USA
HP68/RNase L Inhibitor: A Host Factor Critical for Virion Assembly

Thursday, April 15 | 9:20AM - 9:40AM
Coffee Break
Room: Grand Foyer


Thursday, April 15 | 11:00AM - 1:00PM
Poster Setup
Room: Ballroom A, Grand Foyer


Thursday, April 15 | 1:00PM - 10:00PM
Poster Viewing
Room: Ballroom A, Grand Foyer


Thursday, April 15 | 2:00PM - 4:00PM
Workshop 3: Neuro AIDS and Latency
Room: Garibaldi A/B
Attendance Limited to 125
Speaker 1 of 9
* Janice E. Clements, Johns Hopkins University, USA

Thursday, April 15 | 2:00PM - 4:00PM
Workshop 3: Neuro AIDS and Latency
Room: Garibaldi A/B
Attendance Limited to 125
Speaker 2 of 9
Paul R. Gorry, RMIT University, Australia
Longitudinal Analysis of nef/LTR-Deleted HIV-1 in Blood and CSF of a Long-Term Survivor who Developed HIV-Associated Dementia

Thursday, April 15 | 2:00PM - 4:00PM
Workshop 3: Neuro AIDS and Latency
Room: Garibaldi A/B
Attendance Limited to 125
Speaker 3 of 9
Evelyne E. Schaeffer, Centre de Neurochimie, France
Role of the Envelope in HIV-1 Induced Direct Neuronal Cell Damage

Thursday, April 15 | 2:00PM - 4:00PM
Workshop 3: Neuro AIDS and Latency
Room: Garibaldi A/B
Attendance Limited to 125
Speaker 4 of 9
Paul R. Clapham, University of Massachusetts Medical School, USA
Biological Analysis of HIV-1 R5 Envelopes Amplified by PCR from Brain and Lymph Node Tissue of AIDS Patients with Neuropathology

Thursday, April 15 | 2:00PM - 4:00PM
Workshop 3: Neuro AIDS and Latency
Room: Garibaldi A/B
Attendance Limited to 125
Speaker 5 of 9
Justyna M. Dudaronek, Johns Hopkins School of Medicine, USA
Regulation of Viral Gene Expression in the CNS by Innate Immune Responses during Acute SIV Infection

Thursday, April 15 | 2:00PM - 4:00PM
Workshop 3: Neuro AIDS and Latency
Room: Garibaldi A/B
Attendance Limited to 125
Speaker 6 of 9
Michael R. Nonnemacher, Drexel University College of Medicine, USA
An Enhanced Preference for a High Affinity Interaction between HIV-1 Vpr and Sequences within C/EBP Site I Correlates with HIV-1 Associated Dementia

Thursday, April 15 | 2:00PM - 4:00PM
Workshop 3: Neuro AIDS and Latency
Room: Garibaldi A/B
Attendance Limited to 125
Speaker 7 of 9
Yefei Han, Johns Hopkins School of Medicine, USA
Latent HIV-1 Genomes Reside in Actively Transcribed Genes in Resting CD4+ T Cells in vivo

Thursday, April 15 | 2:00PM - 4:00PM
Workshop 3: Neuro AIDS and Latency
Room: Garibaldi A/B
Attendance Limited to 125
Speaker 8 of 9
Samuel Ambler Williams, Gladstone Institute, USA
NF-kappaB/Rel Transcription Factors and the Regulation of HIV Postintegration Latency

Thursday, April 15 | 2:00PM - 4:00PM
Workshop 3: Neuro AIDS and Latency
Room: Garibaldi A/B
Attendance Limited to 125
Speaker 9 of 9
Leor S. Weinberger, University of California, San Francisco, USA
Stochastic Switching in HIV-1 Tat Transactivation as a Possible Mechanism Leading to HIV-1 Proviral Latency

Thursday, April 15 | 2:00PM - 4:00PM
Workshop 3: Mechanisms of Antibody-Mediated Neutralization a
nd Escape
This session is from HIV Vaccine
Room: Ballroom B, C

Speaker 1 of 8
* John R. Mascola, NIAID, National Institutes of Health, USA


Thursday, April 15 | 2:00PM - 4:00PM
Workshop 3: Mechanisms of Antibody-Mediated Neutralization a
nd Escape
This session is from HIV Vaccine
Room: Ballroom B, C

Speaker 2 of 8
Ruth A. McCaffrey, Seattle Biomedical Research Institute, USA
The Immunologically ‘Silent’ Face of gp120 Protects HIV-1 SF162 from Neutralization by Anti-gp120 and Anti-gp41 Antibodies


Thursday, April 15 | 2:00PM - 4:00PM
Workshop 3: Mechanisms of Antibody-Mediated Neutralization a
nd Escape
This session is from HIV Vaccine
Room: Ballroom B, C

Speaker 3 of 8
Carol D. Weiss, US Food and Drug Administration, USA
Escaping Fusion Inhibition: Elusive Tactics of the HIV Envelope Glycoprotein


Thursday, April 15 | 2:00PM - 4:00PM
Workshop 3: Mechanisms of Antibody-Mediated Neutralization a
nd Escape
This session is from HIV Vaccine
Room: Ballroom B, C

Speaker 4 of 8
Robert G. Whalen, Altravax, Inc., USA
Creating Improved Viral Immunogens by Directed Molecular Evolution


Thursday, April 15 | 2:00PM - 4:00PM
Workshop 3: Mechanisms of Antibody-Mediated Neutralization a
nd Escape
This session is from HIV Vaccine
Room: Ballroom B, C

Speaker 5 of 8
Kelly A. Stefano Cole, University of Pittsburgh School of Medicine, USA
Characterization of Antibody Binding Properties Associated with Neutralization of SIV


Thursday, April 15 | 2:00PM - 4:00PM
Workshop 3: Mechanisms of Antibody-Mediated Neutralization a
nd Escape
This session is from HIV Vaccine
Room: Ballroom B, C

Speaker 6 of 8
Ralph A. Pantophlet, Simon Fraser University, Canada
Immunofocusing: Re-Engineering Monomeric gp120 to Promote the Induction of HIV-Neutralizing Antibodies


Thursday, April 15 | 2:00PM - 4:00PM
Workshop 3: Mechanisms of Antibody-Mediated Neutralization a
nd Escape
This session is from HIV Vaccine
Room: Ballroom B, C

Speaker 7 of 8
Cheryl A. Pikora, New England Regional Primate Research Center, USA
Persistence of Neutralization Resistance Despite Removal of gp120, Core, N-linked Glycosylation Sites in SIV239


Thursday, April 15 | 2:00PM - 4:00PM
Workshop 3: Mechanisms of Antibody-Mediated Neutralization a
nd Escape
This session is from HIV Vaccine
Room: Ballroom B, C

Speaker 8 of 8
Miroslaw K. Gorny, New York University School of Medicine, USA
Identification of a New Neutralizing Epitope in gp120


Thursday, April 15 | 4:30PM - 4:45PM
Coffee & Snacks Available
Room: Grand Foyer


Thursday, April 15 | 4:45PM - 7:00PM
HIV Genetic Variation (Joint)
Room: Ballroom B, C

Speaker 1 of 4
Francine McCutchan, PATH, USA
Screening for HIV-1 Dual Infection in Populations Exposed to Multiple Subtypes

Thursday, April 15 | 4:45PM - 7:00PM
HIV Genetic Variation (Joint)
Room: Ballroom B, C

Speaker 2 of 4
* Bette Tina Marie Korber, Los Alamos National Laboratory, USA
Neutralization Antibody Signature Patterns in HIV Sequences

Thursday, April 15 | 4:45PM - 7:00PM
HIV Genetic Variation (Joint)
Room: Ballroom B, C

Speaker 3 of 4
Todd M. Allen, Ragon Institute of MGH, MIT and Harvard, USA
Short Talk: Stereotypic Escape from CD8T Cell Responses as a Major Driving Force of HIV-1 Sequence Evolution

Thursday, April 15 | 4:45PM - 7:00PM
HIV Genetic Variation (Joint)
Room: Ballroom B, C

Speaker 4 of 4
Dean H. Hamer, National Institutes of Health, USA
Short Talk: HIV-Specific CD4 T Cells are a Hot Spot for Viral Evolution

Thursday, April 15 | 7:00PM - 8:00PM
Social Hour
Room: Ballroom A, Grand Foyer


Thursday, April 15 | 7:30PM - 10:00PM
Poster Session 3
Room: Ballroom A, Grand Foyer


Friday, April 16 | 6:30AM - 8:00AM
Breakfast
Room: Lower Level


Friday, April 16 | 8:00AM - 11:00AM
Nef Function
Room: Ballroom C

Speaker 1 of 5
John C. Guatelli, University of California, San Diego, USA
Nef, Intracellular Protein Trafficking, and Viral Infectivity

Friday, April 16 | 8:00AM - 11:00AM
Nef Function
Room: Ballroom C

Speaker 2 of 5
* Kathleen L. Collins, University of Michigan Medical Center, USA
Nef-Mediated MHC-1 Downmodulation in T Cells

Friday, April 16 | 8:00AM - 11:00AM
Nef Function
Room: Ballroom C

Speaker 3 of 5
Kalle Saksela, University of Helsinki, Finland
Cellular Activation by HIV-1 Accessory Proteins

Friday, April 16 | 8:00AM - 11:00AM
Nef Function
Room: Ballroom C

Speaker 4 of 5
Andreas Stephan Baur, Germany
Nef Signaling in T Cells and HIV Replication: New Insights into the Molecular Mechanism

Friday, April 16 | 8:00AM - 11:00AM
Nef Function
Room: Ballroom C

Speaker 5 of 5
Olivier Schwartz, Institut Pasteur, France
Role of HIV-1 Nef during Viral Replication in Primary Cells

Friday, April 16 | 8:00AM - 11:20AM
Novel Approaches to HIV Vaccination
This session is from HIV Vaccine
Room: Ballroom B

Speaker 1 of 7
Jeffrey D. Lifson, Leidos Biomedical Research, Inc., USA
Whole Inactivated AIDS Virus Virions with Functional Envelope Glycoproteins


Friday, April 16 | 8:00AM - 11:20AM
Novel Approaches to HIV Vaccination
This session is from HIV Vaccine
Room: Ballroom B

Speaker 2 of 7
Richard W. Compans, Emory University, Rollins Research Center, USA
Virus-like Particles as HIV Immunogens


Friday, April 16 | 8:00AM - 11:20AM
Novel Approaches to HIV Vaccination
This session is from HIV Vaccine
Room: Ballroom B

Speaker 3 of 7
* Norman L. Letvin, Beth Israel Deaconess Medical Center, USA
A Multi-Clade Envelope-Based Vaccine Strategy for HIV


Friday, April 16 | 8:00AM - 11:20AM
Novel Approaches to HIV Vaccination
This session is from HIV Vaccine
Room: Ballroom B

Speaker 4 of 7
Stephen A. Udem, Wyeth Pharmaceuticals, USA
VSV as an HIV Vaccine Vector


Friday, April 16 | 8:00AM - 11:20AM
Novel Approaches to HIV Vaccination
This session is from HIV Vaccine
Room: Ballroom B

Speaker 5 of 7
Hildegund C.J. Ertl, Wistar Institute, USA
Simian-Derived E1-Deleted Adenovirus Vectors for HIV Vaccination


Friday, April 16 | 8:00AM - 11:20AM
Novel Approaches to HIV Vaccination
This session is from HIV Vaccine
Room: Ballroom B

Speaker 6 of 7
Dan H. Barouch, Beth Israel Deaconess Medical Center, USA
Short Talk: Low Seroprevalence of Adenovirus Serotype 35 and Immunogenicity of rAd35-Gag Vaccine in Mice with Pre-Existing Anti-Ad5 Immunity


Friday, April 16 | 8:00AM - 11:20AM
Novel Approaches to HIV Vaccination
This session is from HIV Vaccine
Room: Ballroom B

Speaker 7 of 7
Adam C. Soloff, University of Pittsburgh, USA
Short Talk: Dual Adenoviral-Based Vaccination Using Serotypes 5 and 35 Induces Broad T Cell Responses to SIV which are Recalled with Heterologous Challenge


Friday, April 16 | 9:20AM - 9:40AM
Coffee Break
Room: Grand Foyer


Friday, April 16 | 11:00AM - 1:00PM
Poster Setup
Room: Ballroom A, Grand Foyer


Friday, April 16 | 1:00PM - 10:00PM
Poster Viewing
Room: Ballroom A, Grand Foyer


Friday, April 16 | 2:00PM - 4:15PM
Workshop 4: HIV Entry, Early Events
Room: Ballroom C

Speaker 1 of 10
* Didier Trono, Ecole Polytechnique Fédérale de Lausanne, Switzerland

Friday, April 16 | 2:00PM - 4:15PM
Workshop 4: HIV Entry, Early Events
Room: Ballroom C

Speaker 2 of 10
Sophie Holuigue, Windeyer Institute of Medical Sciences, University College London, UK
Antibodies Capable of Inactivating HIV-1 Arise Coincidentally with the Initial Decline in Viral Load during acute Infection

Friday, April 16 | 2:00PM - 4:15PM
Workshop 4: HIV Entry, Early Events
Room: Ballroom C

Speaker 3 of 10
Severine Bär, Deutsches Krebsforschungszentrum, germany
Dissecting Steps of gp41-Mediated Membrane Fusion by Quantitative
Assays Based on Flow Cytometry: Involvement of the Loop Region in Post Lipid Mixing Events


Friday, April 16 | 2:00PM - 4:15PM
Workshop 4: HIV Entry, Early Events
Room: Ballroom C

Speaker 4 of 10
Ariberto Fassati, University College London, UK
Importin 7 Mediates Nuclear Import of HIV-1 Intracellular Reverse Transcription Complexes

Friday, April 16 | 2:00PM - 4:15PM
Workshop 4: HIV Entry, Early Events
Room: Ballroom C

Speaker 5 of 10
Eric Poeschla, University of Colorado School of Medicine, USA
LEDGF/p75 Determines Cellular Trafficking of Diverse Lentiviral but not Oncoretroviral Integrase Proteins and is a Component of Functional HIV-1 Pre-Integration Complexes

Friday, April 16 | 2:00PM - 4:15PM
Workshop 4: HIV Entry, Early Events
Room: Ballroom C

Speaker 6 of 10
Robert J. Gorelick, National Cancer Institute at Frederick, USA
Involvement of the HIV-1 Nucleocapsid Protein in the Synthesis and
Integration of the Viral DNA during Infection


Friday, April 16 | 2:00PM - 4:15PM
Workshop 4: HIV Entry, Early Events
Room: Ballroom C

Speaker 7 of 10
Malini Mansharamani, Johns Hopkins School of Medicine, USA
Barrier-to-Autointegration Factor (BAF) Binds HIV-1 Gag and MA Proteins

Friday, April 16 | 2:00PM - 4:15PM
Workshop 4: HIV Entry, Early Events
Room: Ballroom C

Speaker 8 of 10
Kelly M. Champagne, Thomas Jefferson University, USA
The Structure and Folding of a Designed HIV-1 Entry Inhibitor

Friday, April 16 | 2:00PM - 4:15PM
Workshop 4: HIV Entry, Early Events
Room: Ballroom C

Speaker 9 of 10
Hugues J.P. Ryser, Boston University School of Medicine, USA
PDI-Mediated Reduction of Disulfide Bonds in Envelope Glycoprotein gp120 is Required for HIV-1 Entry

Friday, April 16 | 2:00PM - 4:15PM
Workshop 4: HIV Entry, Early Events
Room: Ballroom C

Speaker 10 of 10
Alexa Raney, University of Texas Southwestern Medical Center, USA
In vitro Reconstitution of an Active Pak2/Nef Complex

Friday, April 16 | 2:00PM - 4:00PM
Workshop 4: HIV-Immune Evasion
This session is from HIV Vaccine
Room: Ballroom B

Speaker 1 of 6
Marcus Altfeld, Heinrich-Pette-Institute, Germany
Selection, Transmission, and Reversion of an Antigen Processing CTL Escape Mutation in HIV-1


Friday, April 16 | 2:00PM - 4:00PM
Workshop 4: HIV-Immune Evasion
This session is from HIV Vaccine
Room: Ballroom B

Speaker 2 of 6
Annika C. Karlsson, Karolinska Institutet, Sweden
Cellular Immune Responses and Viral Escape in HLA-A2-Positive Patients Following Primary HIV-1 Infection


Friday, April 16 | 2:00PM - 4:00PM
Workshop 4: HIV-Immune Evasion
This session is from HIV Vaccine
Room: Ballroom B

Speaker 3 of 6
Sylvie Le Gall, Massachusetts General Hospital, Harvard Medical School, USA
An HLA B57-Specific Mutation Outside an Immunodominant Epitope Alters Antigen Processing and Leads to CTL Escape


Friday, April 16 | 2:00PM - 4:00PM
Workshop 4: HIV-Immune Evasion
This session is from HIV Vaccine
Room: Ballroom B

Speaker 4 of 6
Todd M. Allen, Ragon Institute of MGH, MIT and Harvard, USA
CD8 T Cell Responses and Viral Escape in HIV-Infected Monozygotic Twins Infected with the Same Virus


Friday, April 16 | 2:00PM - 4:00PM
Workshop 4: HIV-Immune Evasion
This session is from HIV Vaccine
Room: Ballroom B

Speaker 5 of 6
Astrid K.N. Iversen, Weatherall Institute of Molecular Medicine, UK
Functional and Structural Basis for HIV Escape from T Cell Recognition


Friday, April 16 | 2:00PM - 4:00PM
Workshop 4: HIV-Immune Evasion
This session is from HIV Vaccine
Room: Ballroom B

Speaker 6 of 6
Wendy M. Blay, Seattle Biomedical Research Institute, USA
Potential N-Linked Glycosylation Sites Undergo Predictable Patterns of Variation within Constrained Regions of HIV-1 Envelope


Friday, April 16 | 4:30PM - 4:45PM
Coffee & Snacks Available
Room: Grand Foyer


Friday, April 16 | 4:45PM - 7:00PM
NeuroAIDS
Room: Ballroom C

Speaker 1 of 4
* Dana H. Gabuzda, Dana Farber Cancer Institute, USA
Mechanisms of Neuropathogenesis

Friday, April 16 | 4:45PM - 7:00PM
NeuroAIDS
Room: Ballroom C

Speaker 2 of 4
Francisco González-Scarano, University of Texas Health Science Center at San Antonio, USA
Determinants of Microglial/Macrophage Tropism and Replication

Friday, April 16 | 4:45PM - 7:00PM
NeuroAIDS
Room: Ballroom C

Speaker 3 of 4
Karl-Heinz Krause, University of Geneva Faculty of Medicine, Switzerland
HIV, CCR5, and Neurodegeneration

Friday, April 16 | 4:45PM - 7:00PM
NeuroAIDS
Room: Ballroom C

Speaker 4 of 4
Andrew A. Lackner, Tulane National Primate Research Center, USA
Early Events in the Neuropathogenesis of AIDS

Friday, April 16 | 4:45PM - 7:00PM
Therapeutic Vaccination of HIV-Infected Individuals
This session is from HIV Vaccine
Room: Ballroom B

Speaker 1 of 4
Brigitte Autran, Hôpital Pitié-Salpétrière, UPMC, France
Therapeutic Immunization against HIV


Friday, April 16 | 4:45PM - 7:00PM
Therapeutic Vaccination of HIV-Infected Individuals
This session is from HIV Vaccine
Room: Ballroom B

Speaker 2 of 4
Richard A. Koup, NIAID, National Institutes of Health, USA
Therapeutic Vaccines: Hypothesis Testing in vivo


Friday, April 16 | 4:45PM - 7:00PM
Therapeutic Vaccination of HIV-Infected Individuals
This session is from HIV Vaccine
Room: Ballroom B

Speaker 3 of 4
* Nina Bhardwaj, Icahn School of Medicine at Mount Sinai, USA
Stimulating Cellular Immunity with Dendritic Cell Based Vaccines


Friday, April 16 | 4:45PM - 7:00PM
Therapeutic Vaccination of HIV-Infected Individuals
This session is from HIV Vaccine
Room: Ballroom B

Speaker 4 of 4
Bruce D. Walker, Ragon Institute of MGH, MIT and Harvard, USA
Immunology and virology of controlled HIV infection


Friday, April 16 | 7:00PM - 8:00PM
Social Hour
Room: Ballroom A, Grand Foyer


Friday, April 16 | 7:30PM - 10:00PM
Poster Session 4
Room: Ballroom A, Grand Foyer


Saturday, April 17 | 6:30AM - 8:00AM
Breakfast
Room: Lower Level


Saturday, April 17 | 8:00AM - 11:00AM
HIV-1 in the Nucleus
Room: Ballroom C

Speaker 1 of 5
Frederic D. Bushman, University of Pennsylvania, USA
DNA Integration by Retroviruses in the Human Genome

Saturday, April 17 | 8:00AM - 11:00AM
HIV-1 in the Nucleus
Room: Ballroom C

Speaker 2 of 5
* Michael Emerman, Fred Hutchinson Cancer Research Center, USA
HIV Infection of Non-Dividing Cells

Saturday, April 17 | 8:00AM - 11:00AM
HIV-1 in the Nucleus
Room: Ballroom C

Speaker 3 of 5
Katherine A. Jones, The Salk Institute, USA
The c-Ski-Interacting Protein (SKIP) Facilitates Transcription Elongation by HIV-1 Tat

Saturday, April 17 | 8:00AM - 11:00AM
HIV-1 in the Nucleus
Room: Ballroom C

Speaker 4 of 5
Barbara K. Felber, NCI, National Institutes of Health, USA
HIV Posttranscriptional Regulation and Viral Latency

Saturday, April 17 | 8:00AM - 11:00AM
HIV-1 in the Nucleus
Room: Ballroom C

Speaker 5 of 5
Eric M. Verdin, Buck Institute for Research on Aging, USA
Molecular Mechanisms of HIV Latency

Saturday, April 17 | 8:00AM - 11:00AM
Lessons for HIV Vaccine Development from other Vaccines
This session is from HIV Vaccine
Room: Ballroom B

Speaker 1 of 5
William R. Jacobs, Jr., HHMI/Albert Einstein College of Medicine, USA
Novel Strategies for Vaccine Protection Against M. tuberculosis


Saturday, April 17 | 8:00AM - 11:00AM
Lessons for HIV Vaccine Development from other Vaccines
This session is from HIV Vaccine
Room: Ballroom B

Speaker 2 of 5
* Kanta Subbarao, WHO Collaborating Centre for Reference and Research on Influenza, Australia
Preventing Pandemics and Newly Emerging Respiratory Viral Threats through Vaccine Development


Saturday, April 17 | 8:00AM - 11:00AM
Lessons for HIV Vaccine Development from other Vaccines
This session is from HIV Vaccine
Room: Ballroom B

Speaker 3 of 5
Kathrin U. Jansen, Pfizer, USA
Status of Prophylatic Vaccines Against Cervical Cancer


Saturday, April 17 | 8:00AM - 11:00AM
Lessons for HIV Vaccine Development from other Vaccines
This session is from HIV Vaccine
Room: Ballroom B

Speaker 4 of 5
Drew M. Pardoll, Johns Hopkins University School of Medicine, USA
Novel Vaccine Strategies for the Treatment of Cancer


Saturday, April 17 | 8:00AM - 11:00AM
Lessons for HIV Vaccine Development from other Vaccines
This session is from HIV Vaccine
Room: Ballroom B

Speaker 5 of 5
Suzanne L. Topalian, Johns Hopkins University School of Medicine, USA
Immunotherapy of Cancer: Lessons Learned from Melanoma


Saturday, April 17 | 9:00AM - 12:00PM
Entertainment
Room: Ballroom A


Saturday, April 17 | 9:00AM - 12:00PM
Cash Bar
Room: Ballroom A


Saturday, April 17 | 9:20AM - 9:40AM
Coffee Break
Room: Grand Foyer


Saturday, April 17 | 4:30PM - 4:45PM
Coffee & Snacks Available
Room: Grand Foyer


Saturday, April 17 | 4:45PM - 7:15PM
HIV-1 and Protein Trafficking in the Cytoplasm
Room: Ballroom C

Speaker 1 of 6
* Beatrice H. Hahn, University of Pennsylvania, USA

Saturday, April 17 | 4:45PM - 7:15PM
HIV-1 and Protein Trafficking in the Cytoplasm
Room: Ballroom C

Speaker 2 of 6
Mark Marsh, University College London, UK
HIV Assembly in the Endocytic Pathway

Saturday, April 17 | 4:45PM - 7:15PM
HIV-1 and Protein Trafficking in the Cytoplasm
Room: Ballroom C

Speaker 3 of 6
Markus Thali, University of Vermont, USA
HIV-1 Egress is Gated Through Late Endosomal Membranes

Saturday, April 17 | 4:45PM - 7:15PM
HIV-1 and Protein Trafficking in the Cytoplasm
Room: Ballroom C

Speaker 4 of 6
Ganjam V. Kalpana, Albert Einstein College of Medicine, USA
A Novel INI1/hSNF5 Associated HDAC1 Complex is Specifically Incorporated into HIV-1 Virions and is Required for Viral Early Events

Saturday, April 17 | 4:45PM - 7:15PM
HIV-1 and Protein Trafficking in the Cytoplasm
Room: Ballroom C

Speaker 5 of 6
Benjamin K. Chen, Mount Sinai School of Medicine, USA
Chimeric Virus Models to Understand HIV-1 Assembly

Saturday, April 17 | 4:45PM - 7:15PM
HIV-1 and Protein Trafficking in the Cytoplasm
Room: Ballroom C

Speaker 6 of 6
Paul D. Bieniasz, Rockefeller University, USA
GAG Localization and Interaction with Host Factors during Retrovirus Assembly and Budding

Saturday, April 17 | 4:45PM - 7:00PM
Mechanisms of HIV Immune Evasion
This session is from HIV Vaccine
Room: Ballroom B

Speaker 1 of 4
* George M. Shaw, University of Pennsylvania, USA
Immune Control and Escape by HIV-1: Neutralizing Antibodies


Saturday, April 17 | 4:45PM - 7:00PM
Mechanisms of HIV Immune Evasion
This session is from HIV Vaccine
Room: Ballroom B

Speaker 2 of 4
Persephone Borrow, University of Oxford, UK
Escape of HIV-1 from the Primary CTL Response


Saturday, April 17 | 4:45PM - 7:00PM
Mechanisms of HIV Immune Evasion
This session is from HIV Vaccine
Room: Ballroom B

Speaker 3 of 4
David I. Watkins, University of Miami, USA
SIV Escape from CTL


Saturday, April 17 | 4:45PM - 7:00PM
Mechanisms of HIV Immune Evasion
This session is from HIV Vaccine
Room: Ballroom B

Speaker 4 of 4
Philip J. Goulder, University of Oxford, UK
HIV Evolution: CTL Escape Mutation and Reversion following Transmission


Saturday, April 17 | 8:00PM - 9:00PM
Social Hour
Room: Ballroom A


Sunday, April 18 | 10:26AM - 10:26AM
Departure


*Session Chair.