Web Desc
HIV Vaccine Development: Progress and Prospects
joint with Molecular Mechanisms of HIV Pathogenesis
Organizer(s): Norman L. Letvin, Nina Bhardwaj and Barney S. Graham
Date: April 12 - 18, 2004
Location: Whistler Conference Centre, Whistler, BC, Canada
Sponsored by Wyeth Vaccines Research
For important information on the coronavirus, please click here
Summary of Meeting:
The magnitude of the world-wide public health problem posed by HIV is well known. Control of the AIDS epidemic will only come with the development of a successful vaccine. The potential efficacy of both cellular and humoral immune responses in controlling HIV replication is now well documented. However, the ability of the virus to mutate away from recognition by T lymphocytes and neutralizing antibody continues to frustrate attempts to make a successful vaccine. A number of recent observations have dramatically increased the optimism of those involved in HIV vaccine development. It is now clear that vaccine-elicited cellular immune responses can contribute to containing the level of viral replication and delay the progression of clinical disease following an AIDS virus infection in nonhuman primates. It has also recently been shown that monoclonal antibodies that neutralize a diversity of HIV isolates can protect against HIV infection of nonhuman primates when passively administered to animals prior to challenge. Finally, a number of novel vaccine strategies are showing promise in early clinical trials in eliciting relevant immune responses in human volunteers. A meeting on HIV vaccines in 2004 will be extremely timely, in that data from large scale human trials of promising vaccine candidates will be available at that time for presentation. A number of early phase trials with a newer generation of vaccine candidates will also just be initiated and data will be available from those trials. Finally, new data from basic immunology and AIDS immunopathogenesis studies will be available for presentations that bear on the creation of new strategies for HIV vaccination. The Keystone HIV Vaccine Meeting has become recognized as the most important forum for presenting new data in this important area of research. The meeting is attended annually by the most important investigators in the field worldwide. There is every reason to suppose that this will continue to be the case.
Discounted Abstract Deadline: December 11 2003
Discounted Registration Deadline: February 12 2004
We have reached maximum abstract capacity for this meeting.


We gratefully acknowledge additional support for this conference from:
Beckman Coulter Foundation, Inc.Bill & Melinda Gates FoundationOffice of AIDS Research, NIHWyeth Vaccines Research
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI58748-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Monday, April 12 | 3:00PM - 7:00PM
Registration
Room: Grand Foyer


Monday, April 12 | 6:15PM - 7:15PM
Refreshments
Room: Grand Foyer


Monday, April 12 | 7:15PM - 7:30PM
Orientation
Room: Ballroom B, C


Monday, April 12 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Ballroom B, C

Speaker 1 of 3
* Norman L. Letvin, Beth Israel Deaconess Medical Center, USA

Monday, April 12 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Ballroom B, C

Speaker 2 of 3
Gary J. Nabel, Sanofi, USA
The Gene Product Murr1 Restricts HIV-1 Replication in Resting CD4+ Lymphocytes

Monday, April 12 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Ballroom B, C

Speaker 3 of 3
Wesley I. Sundquist, University of Utah School of Medicine, USA
The Biochemistry of HIV-1 Release

Tuesday, April 13 | 6:30AM - 8:00AM
Breakfast
Room: Lower Level


Tuesday, April 13 | 8:00AM - 11:00AM
HIV Entry Mechanisms and Neutralizing Antibodies (Joint)
Room: Ballroom B, C

Speaker 1 of 6
* Joseph G. Sodroski, Dana-Farber Cancer Institute, USA
Innate Intracellular Immunity to HIV-1 in Old World Monkeys

Tuesday, April 13 | 8:00AM - 11:00AM
HIV Entry Mechanisms and Neutralizing Antibodies (Joint)
Room: Ballroom B, C

Speaker 2 of 6
David C. Montefiori, Duke University Medical Center, USA
Neutralizing Antibodies Induced by Candidate HIV-1 Vaccines

Tuesday, April 13 | 8:00AM - 11:00AM
HIV Entry Mechanisms and Neutralizing Antibodies (Joint)
Room: Ballroom B, C

Speaker 3 of 6
Alexandra Trkola, University of Zürich, Switzerland
Antibodies: Surrogate or Supporter of Protective Immunity?

Tuesday, April 13 | 8:00AM - 11:00AM
HIV Entry Mechanisms and Neutralizing Antibodies (Joint)
Room: Ballroom B, C

Speaker 4 of 6
Susan Zolla-Pazner, Icahn School of Medicine at Mount Sinai, USA
The V3 Loop: Always Changing, Always the Same

Tuesday, April 13 | 8:00AM - 11:00AM
HIV Entry Mechanisms and Neutralizing Antibodies (Joint)
Room: Ballroom B, C

Speaker 5 of 6
Gregory B. Melikian, Emory University, USA
Short Talk: Dissecting the Steps of HIV ENV-Induced Fusion: Coreceptor Engagement, Fusion Pore Formation, and Pore Enlargement

Tuesday, April 13 | 8:00AM - 11:00AM
HIV Entry Mechanisms and Neutralizing Antibodies (Joint)
Room: Ballroom B, C

Speaker 6 of 6
James Mark Binley, San Diego Biomedical Research Institute, USA
Short Talk: Comprehensive Cross-Clade Neutralization Analysis of a Panel of Anti-HIV Monoclonal Antibodies and a Clade B HIV+ Plasma

Tuesday, April 13 | 9:20AM - 9:40AM
Coffee Break
Room: Grand Foyer


Tuesday, April 13 | 11:00AM - 1:00PM
Poster Setup
Room: Ballroom A, Grand Foyer


Tuesday, April 13 | 1:00PM - 10:00PM
Poster Viewing
Room: Ballroom A, Grand Foyer


Tuesday, April 13 | 2:00PM - 4:15PM
Workshop 1: HIV Envelope Structure and Neutralization
Room: Ballroom B, C

Speaker 1 of 10
* Richard T. Wyatt, IAVI Neutralizing Antibody Center, The Scripps Research Institute, USA

Tuesday, April 13 | 2:00PM - 4:15PM
Workshop 1: HIV Envelope Structure and Neutralization
Room: Ballroom B, C

Speaker 2 of 10
Barna Dey, NIAID, National Institutes of Health, USA
Characterization of Mutant HIV-1 Envelope Glycoproteins Stabilized in the CD4-Bound Conformation

Tuesday, April 13 | 2:00PM - 4:15PM
Workshop 1: HIV Envelope Structure and Neutralization
Room: Ballroom B, C

Speaker 3 of 10
Kathy P. Fernando, University of Pennsylvania, USA
HIV Env Lacking CD4 Binding as a Vaccine Approach

Tuesday, April 13 | 2:00PM - 4:15PM
Workshop 1: HIV Envelope Structure and Neutralization
Room: Ballroom B, C

Speaker 4 of 10
Marie Pancera, Fred Hutchinson Cancer Research Center, USA
Characterization of Stabilized Trimeric HIV-1 gp120 Envelope Glycoprotein

Tuesday, April 13 | 2:00PM - 4:15PM
Workshop 1: HIV Envelope Structure and Neutralization
Room: Ballroom B, C

Speaker 5 of 10
Suganya Selvarajah, The Scripps Research Institute, USA
Modified gp140 Trimers to Elicit b12-Like Antibodies

Tuesday, April 13 | 2:00PM - 4:15PM
Workshop 1: HIV Envelope Structure and Neutralization
Room: Ballroom B, C

Speaker 6 of 10
Chinglai Yang, Emory University, USA
Characterization of an HA/Gp41 Chimeric Protein: Enhanced Interaction with the Broadly Neutralizing Monoclonal Antibody 2F5 against HIV

Tuesday, April 13 | 2:00PM - 4:15PM
Workshop 1: HIV Envelope Structure and Neutralization
Room: Ballroom B, C

Speaker 7 of 10
Jason E. Hammonds, Emory University, USA
Induction of Antibody Responses to CD4-Induced Epitopes by Induced Pseudovirions and Recombinant Protein Immunogens

Tuesday, April 13 | 2:00PM - 4:15PM
Workshop 1: HIV Envelope Structure and Neutralization
Room: Ballroom B, C

Speaker 8 of 10
Jonathan M. Gershoni, Tel Aviv University, Israel
Backtracking from mAb to Epitope - A Combinatorial Approach

Tuesday, April 13 | 2:00PM - 4:15PM
Workshop 1: HIV Envelope Structure and Neutralization
Room: Ballroom B, C

Speaker 9 of 10
Carolina Herrera, Imperial College, UK
Consequences of HIV-1 Env Cleavage on Antigenicity, Infectivity, and Neutralization

Tuesday, April 13 | 2:00PM - 4:15PM
Workshop 1: HIV Envelope Structure and Neutralization
Room: Ballroom B, C

Speaker 10 of 10
Gerald V. Quinnan, Jr., Uniformed Services University Health Sciences, USA
Protection Against Rhesus Monkey Adapted-SHIV Challenge by Active Induction of HIV-1 Neutralizing Antibodies or SIV gag-Specific Cytotoxic T Cells

Tuesday, April 13 | 2:00PM - 4:00PM
Workshop 1: HIV Accessory Protein and Assembly
This session is from HIV Pathogenesis
Room: Garibaldi A/B
Attendance Limited to 125
Speaker 1 of 9
* Wesley I. Sundquist, University of Utah School of Medicine, USA
Following the RNA


Tuesday, April 13 | 2:00PM - 4:00PM
Workshop 1: HIV Accessory Protein and Assembly
This session is from HIV Pathogenesis
Room: Garibaldi A/B
Attendance Limited to 125
Speaker 2 of 9

SIRT1 Deacetylates the HIV Tat Protein and is Required for Tat-Mediated Transactivation of the HIV Promoter


Tuesday, April 13 | 2:00PM - 4:00PM
Workshop 1: HIV Accessory Protein and Assembly
This session is from HIV Pathogenesis
Room: Garibaldi A/B
Attendance Limited to 125
Speaker 3 of 9
Roger J. Pomerantz, Seres Therapeutics, Inc., USA
A Dead Box Protein is as a Critical Cellular Co-Factor of HIV-1 REV: Effects on Viral Persistence and Reservoirs in Different Cell-Types


Tuesday, April 13 | 2:00PM - 4:00PM
Workshop 1: HIV Accessory Protein and Assembly
This session is from HIV Pathogenesis
Room: Garibaldi A/B
Attendance Limited to 125
Speaker 4 of 9
Chad M. Swanson, King's College London, UK
A Link between Viral Assembly and Nuclear Export


Tuesday, April 13 | 2:00PM - 4:00PM
Workshop 1: HIV Accessory Protein and Assembly
This session is from HIV Pathogenesis
Room: Garibaldi A/B
Attendance Limited to 125
Speaker 5 of 9
Andrew J. Mouland, McGill University, Lady Davis Institute, Canada
The Specific Association of hnRNP A2 to its Cognate Response Sequence in HIV-1 RNA Implications in Viral Assembly


Tuesday, April 13 | 2:00PM - 4:00PM
Workshop 1: HIV Accessory Protein and Assembly
This session is from HIV Pathogenesis
Room: Garibaldi A/B
Attendance Limited to 125
Speaker 6 of 9
Heinrich Göttlinger, Dana Farber Cancer Institute, USA
Roles of AIP1 and ESCRT-III in HIV Budding


Tuesday, April 13 | 2:00PM - 4:00PM
Workshop 1: HIV Accessory Protein and Assembly
This session is from HIV Pathogenesis
Room: Garibaldi A/B
Attendance Limited to 125
Speaker 7 of 9
Marc C. Johnson, Cornell University, USA
Visual Comparison of Retroviral Late-Domain Phenotypes


Tuesday, April 13 | 2:00PM - 4:00PM
Workshop 1: HIV Accessory Protein and Assembly
This session is from HIV Pathogenesis
Room: Garibaldi A/B
Attendance Limited to 125
Speaker 8 of 9
Rebecca J. Loomis, University of North Carolina at Chapel Hill, USA
Citron Kinase, a RhoA Effector, Enhances HIV-1 Virion Release


Tuesday, April 13 | 2:00PM - 4:00PM
Workshop 1: HIV Accessory Protein and Assembly
This session is from HIV Pathogenesis
Room: Garibaldi A/B
Attendance Limited to 125
Speaker 9 of 9
Vicente Planelles, University of Utah, USA
The Mechanisms of HIV-1 VPR-Mediated G2 Arrest and Apoptosis: Role of the Host Cell DNA Damage Signaling Pathway


Tuesday, April 13 | 4:30PM - 4:45PM
Coffee & Snacks Available
Room: Grand Foyer


Tuesday, April 13 | 4:45PM - 7:00PM
Natural SIV Infection: Lessons from the Monkey (Joint)
Room: Ballroom B, C

Speaker 1 of 5
* Paul M. Sharp, University of Edinburgh, UK
Evolution from SIV to HIV

Tuesday, April 13 | 4:45PM - 7:00PM
Natural SIV Infection: Lessons from the Monkey (Joint)
Room: Ballroom B, C

Speaker 2 of 5
Beatrice H. Hahn, University of Pennsylvania, USA
Molecular Epidemiology of Simian Immunodeficiency Virus Infection in Wild Chimpanzees

Tuesday, April 13 | 4:45PM - 7:00PM
Natural SIV Infection: Lessons from the Monkey (Joint)
Room: Ballroom B, C

Speaker 3 of 5
Mark B. Feinberg, IAVI International AIDS Vaccine Initiative, USA
Host-Virus Relationships Underlying Non-Pathogenic SIV Infections

Tuesday, April 13 | 4:45PM - 7:00PM
Natural SIV Infection: Lessons from the Monkey (Joint)
Room: Ballroom B, C

Speaker 4 of 5
Greg J. Towers, University College London, UK
Restriction of retroviral infection by TRIM5

Tuesday, April 13 | 4:45PM - 7:00PM
Natural SIV Infection: Lessons from the Monkey (Joint)
Room: Ballroom B, C

Speaker 5 of 5
Nathaniel R. Landau, New York University School of Medicine, USA
Short Talk: Mechanism of APOBEC3G Deamination of HIV Reverse Transcripts

Tuesday, April 13 | 7:00PM - 8:00PM
Social Hour
Room: Ballroom A, Grand Foyer


Tuesday, April 13 | 7:30PM - 10:00PM
Poster Session 1
Room: Ballroom A, Grand Foyer


Wednesday, April 14 | 6:30AM - 8:00AM
Breakfast
Room: Lower Level


Wednesday, April 14 | 8:00AM - 9:30AM
Current Issues in the Clinical Evaluation of Vaccines
Room: Ballroom B

Speaker 1 of 3
John W. Shiver, Sanofi Pasteur, USA
Development of an HIV-1 Vaccine Based on Replication-Defective Adenovirus

Wednesday, April 14 | 8:00AM - 9:30AM
Current Issues in the Clinical Evaluation of Vaccines
Room: Ballroom B

Speaker 2 of 3
* Barney S. Graham, NIAID, National Institutes of Health, USA
Update of Trials of Multi-Clade DNA and Recombinant Adenovirus Vaccines


Wednesday, April 14 | 8:00AM - 9:30AM
Current Issues in the Clinical Evaluation of Vaccines
Room: Ballroom B

Speaker 3 of 3
Lawrence Corey, Fred Hutchinson Cancer Research Center, USA
Update of HVTN Clinical Trials

Wednesday, April 14 | 8:00AM - 11:00AM
HIV Genome RNA: From the Nucleus to the Plasma Membrane
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 1 of 5
* Tristram G. Parslow, Emory University, USA
The HIV-1 Genomic Dimer Interface as a Target for Structure-Based Drug Design


Wednesday, April 14 | 8:00AM - 11:00AM
HIV Genome RNA: From the Nucleus to the Plasma Membrane
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 2 of 5
Kathleen A. Boris-Lawrie, Ohio State University, USA
The Destiny of Retroviral Unspliced RNA: Ribosome or Virion?


Wednesday, April 14 | 8:00AM - 11:00AM
HIV Genome RNA: From the Nucleus to the Plasma Membrane
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 3 of 5
Casey D. Morrow, University of Alabama at Birmingham, USA
Selection of the tRNA Primer required for HIV Replication


Wednesday, April 14 | 8:00AM - 11:00AM
HIV Genome RNA: From the Nucleus to the Plasma Membrane
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 4 of 5
Chantal Ehresmann, IBMC du Centre National de la Recherche Scientifique, France
The 5' -Untranslated Region of HIV-1 Genomic RNA: Structure and Functional Implications


Wednesday, April 14 | 8:00AM - 11:00AM
HIV Genome RNA: From the Nucleus to the Plasma Membrane
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 5 of 5
James R. Williamson, The Scripps Research Institute, USA
Toward Inhibition of HIV Rev-RRE Interactions: Challenges for Targeting RNA


Wednesday, April 14 | 9:30AM - 9:50AM
Coffee Break
Room: Grand Foyer


Wednesday, April 14 | 9:50AM - 11:30AM
Roundtable Discussion: Immunogenicity Criteria for Advancing
Candidate Vaccines into Phase III Trials
Room: Ballroom B

Speaker 1 of 8
* Gary J. Nabel, Sanofi, USA

Wednesday, April 14 | 9:50AM - 11:30AM
Roundtable Discussion: Immunogenicity Criteria for Advancing
Candidate Vaccines into Phase III Trials
Room: Ballroom B

Speaker 2 of 8
Dennis R. Burton, The Scripps Research Institute, USA
Criteria for Neutralizing Antibody Responses

Wednesday, April 14 | 9:50AM - 11:30AM
Roundtable Discussion: Immunogenicity Criteria for Advancing
Candidate Vaccines into Phase III Trials
Room: Ballroom B

Speaker 3 of 8
Hana Golding, US Food and Drug Administration, USA
Regulatory Perspective

Wednesday, April 14 | 9:50AM - 11:30AM
Roundtable Discussion: Immunogenicity Criteria for Advancing
Candidate Vaccines into Phase III Trials
Room: Ballroom B

Speaker 4 of 8
Emilio A. Emini, Bill and Melinda Gates Foundation, USA
Manufacturer's Perspective

Wednesday, April 14 | 9:50AM - 11:30AM
Roundtable Discussion: Immunogenicity Criteria for Advancing
Candidate Vaccines into Phase III Trials
Room: Ballroom B

Speaker 5 of 8
John G. McNeil, Sanofi-Pasteur, USA
Clinical Perspective

Wednesday, April 14 | 9:50AM - 11:30AM
Roundtable Discussion: Immunogenicity Criteria for Advancing
Candidate Vaccines into Phase III Trials
Room: Ballroom B

Speaker 6 of 8
Steve G. Self, Fred Hutchinson Cancer Research Center, USA
Statistical Perspective

Wednesday, April 14 | 9:50AM - 11:30AM
Roundtable Discussion: Immunogenicity Criteria for Advancing
Candidate Vaccines into Phase III Trials
Room: Ballroom B

Speaker 7 of 8
Andrew J. McMichael, Oxford University, UK
Criteria for T Cell Responses

Wednesday, April 14 | 9:50AM - 11:30AM
Roundtable Discussion: Immunogenicity Criteria for Advancing
Candidate Vaccines into Phase III Trials
Room: Ballroom B

Speaker 8 of 8
John P. Moore, Weill Medical College of Cornell University, USA
Criteria for Neutralizing Antibody Responses

Wednesday, April 14 | 11:00AM - 1:00PM
Poster Setup
Room: Ballroom A, Grand Foyer


Wednesday, April 14 | 1:00PM - 10:00PM
Poster Viewing
Room: Ballroom A, Grand Foyer


Wednesday, April 14 | 2:00PM - 4:00PM
Workshop 2: Immunobiology of HIV Infection
Room: Ballroom B

Speaker 1 of 7
* Luis J. Montaner, Wistar Institute, USA

Wednesday, April 14 | 2:00PM - 4:00PM
Workshop 2: Immunobiology of HIV Infection
Room: Ballroom B

Speaker 2 of 7
David Favre, GlaxoSmithKline, USA
Generation of Dysfunctional CD8+ T Cells in the Setting of HIV Infection

Wednesday, April 14 | 2:00PM - 4:00PM
Workshop 2: Immunobiology of HIV Infection
Room: Ballroom B

Speaker 3 of 7
Daniel E. Kaufmann, University of Montreal, Canada
Promiscuous Presentation of the Same Epitopes by Different HLA Class II Alleles and Clustering of Overlapping Epitopes both Contribute to the High Frequency of Recognition by CD4 Cells of a Limited Subset of Gag and Nef HIV-1 Peptides

Wednesday, April 14 | 2:00PM - 4:00PM
Workshop 2: Immunobiology of HIV Infection
Room: Ballroom B

Speaker 4 of 7
Christian Brander, Institut de Recerca de la Sida, IrsiCaixa, Spain
HLA-B63 (B*1516/B*1517) Presents HLA-B57 Restricted CTL Epitopes and is Associated with Slow HIV Disease Progression

Wednesday, April 14 | 2:00PM - 4:00PM
Workshop 2: Immunobiology of HIV Infection
Room: Ballroom B

Speaker 5 of 7
Marie-Claire E. Gauduin, Texas Biomedical Research Institute, USA
Depletion of CD8+ Lymphocytes Results in Rebound Viremia in SIV-Infected Macaques with Undetectable Viral Replication following Early Antiretroviral Therapy

Wednesday, April 14 | 2:00PM - 4:00PM
Workshop 2: Immunobiology of HIV Infection
Room: Ballroom B

Speaker 6 of 7
David A. Garber, Emory University, USA
Enhancing the Immunogenicity of MVA-based AIDS Vaccines

Wednesday, April 14 | 2:00PM - 4:00PM
Workshop 2: Immunobiology of HIV Infection
Room: Ballroom B

Speaker 7 of 7
Shan Lu, University of Massachusetts Medical Center, USA
Immunogenicity of Monovalent and Polyvalent DNA Prime/Protein Boost Formulations Encoding Primary HIV-1 Env Antigens as Tested in Rabbits and Non-Human Primate Models

Wednesday, April 14 | 2:00PM - 4:00PM
Workshop 2: The Viral Synapse
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 1 of 9
* Michael H. Malim, King's College London, UK


Wednesday, April 14 | 2:00PM - 4:00PM
Workshop 2: The Viral Synapse
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 2 of 9
Vincent Piguet, Cardiff University, UK
DC-SIGN-Mediated Infectious Synapse Formation Enhances Transfer of HIV Infection from Dendritic Cells to T Cells


Wednesday, April 14 | 2:00PM - 4:00PM
Workshop 2: The Viral Synapse
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 3 of 9
Clare Jolly, University College London, UK
HIV-1 Exploits an Env-Induced Synapse in CD4+ T Cells


Wednesday, April 14 | 2:00PM - 4:00PM
Workshop 2: The Viral Synapse
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 4 of 9
Philippe Gallay, The Scripps Research Institute, USA
A Highly Conserved Arginine in the V3 Loop of Gp120 Governs HIV-1 Binding to Coreceptors and Syndecans


Wednesday, April 14 | 2:00PM - 4:00PM
Workshop 2: The Viral Synapse
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 5 of 9
Teunis B.H. Geijtenbeek, University of Amsterdam, Netherlands
Mechanisms of DC-Sign Mediated Function in HIV-1 Infection


Wednesday, April 14 | 2:00PM - 4:00PM
Workshop 2: The Viral Synapse
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 6 of 9
Rahm Gummuluru, Boston University School of Medicine, USA
Mechanism of DC-SIGN Mediated HIV-1 Transmission


Wednesday, April 14 | 2:00PM - 4:00PM
Workshop 2: The Viral Synapse
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 7 of 9
David McDonald, National Institute of Allergy and Infectious Disease, USA
Enhancement of HIV Infection by Activated Dendritic Cells Occurs via
Trafficking through a CD81 Enriched Compartment


Wednesday, April 14 | 2:00PM - 4:00PM
Workshop 2: The Viral Synapse
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 8 of 9
Ann-Marie M. Roy, University of California, San Francisco, USA
Impact of Coreceptor Use on HIV-1 Viral Output per Infected Cell


Wednesday, April 14 | 2:00PM - 4:00PM
Workshop 2: The Viral Synapse
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 9 of 9
John Wilkinson, Westmead Millennium Institute, Australia
Increased HIV-1 Uptake in Immature Dendritic Cells and Increased Viral Transfer to CD4+ T Cells as a Result of Inhibition of the Endosomal - Lysosomal Degradation Pathway


Wednesday, April 14 | 4:30PM - 4:45PM
Coffee & Snacks Available
Room: Grand Foyer


Wednesday, April 14 | 4:45PM - 7:00PM
Advances in Immunobiology
Room: Ballroom B

Speaker 1 of 4
Arlene H. Sharpe, Harvard Medical School, USA
Current Understanding of Immune Co-Stimulation


Wednesday, April 14 | 4:45PM - 7:00PM
Advances in Immunobiology
Room: Ballroom B

Speaker 2 of 4
* Antonio Lanzavecchia, Institute for Research in Biomedicine, Switzerland
Induction and Maintenance of Serological Memory

Wednesday, April 14 | 4:45PM - 7:00PM
Advances in Immunobiology
Room: Ballroom B

Speaker 3 of 4
Jonathan W. Yewdell, NIAID, National Institutes of Health, USA
Induction of TCD8+ Responses by Viruses

Wednesday, April 14 | 4:45PM - 7:00PM
Advances in Immunobiology
Room: Ballroom B

Speaker 4 of 4
Eli Gilboa, University of Miami, Miller School of Medicine, USA
Therapeutic Vaccination with mRNA Transfected Dendritic Cells for Cancer and Infectious Diseases

Wednesday, April 14 | 4:45PM - 7:15PM
Immediate Early Steps in Viral Entry and Uncoating
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 1 of 5
* John P. Moore, Weill Medical College of Cornell University, USA
Effect of a Small Molecule CCR5 Inhibitor on Virus Infection in the Rhesus Macaque


Wednesday, April 14 | 4:45PM - 7:15PM
Immediate Early Steps in Viral Entry and Uncoating
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 2 of 5
John A. T. Young, F.Hoffmann-La Roche Ltd, Switzerland
Cellular Factor Requirement in HIV-1 Uncoating Revealed by a Cell-Free System


Wednesday, April 14 | 4:45PM - 7:15PM
Immediate Early Steps in Viral Entry and Uncoating
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 3 of 5
Christopher Aiken, Vanderbilt University School of Medicine, USA
Capsid Disassembly and HIV-1 Infection


Wednesday, April 14 | 4:45PM - 7:15PM
Immediate Early Steps in Viral Entry and Uncoating
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 4 of 5
Thomas J. Hope, Northwestern University, USA
HIV Entry and Early Events (Cytoplasmic Trafficking)


Wednesday, April 14 | 4:45PM - 7:15PM
Immediate Early Steps in Viral Entry and Uncoating
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 5 of 5
Vineet N. KewalRamani, NCI, National Institutes of Health, USA
Cell and Molecular Requirements for DC-SIGN-Mediated HIV Transmission


Wednesday, April 14 | 7:00PM - 8:00PM
Social Hour
Room: Ballroom A, Grand Foyer


Wednesday, April 14 | 7:30PM - 10:00PM
Poster Session 2
Room: Ballroom A, Grand Foyer


Thursday, April 15 | 6:30AM - 8:00AM
Breakfast
Room: Lower Level


Thursday, April 15 | 8:00AM - 11:30AM
Innate Intracellular Antiviral Responses (Joint)
Room: Ballroom B, C

Speaker 1 of 6
Michael H. Malim, King's College London, UK
Vif, cytidine deamination and HIV replication

Thursday, April 15 | 8:00AM - 11:30AM
Innate Intracellular Antiviral Responses (Joint)
Room: Ballroom B, C

Speaker 2 of 6
Warner Craig Greene, Gladstone Institute of Virology and Immunology, USA
HIV Vif versus the Antiviral APOBEC3G Enzyme: New Insights into the Mechanism of Vif Action

Thursday, April 15 | 8:00AM - 11:30AM
Innate Intracellular Antiviral Responses (Joint)
Room: Ballroom B, C

Speaker 3 of 6
Didier Trono, Ecole Polytechnique Fédérale de Lausanne, Switzerland
Innate Intracellular defenses Against Retroelements


Thursday, April 15 | 8:00AM - 11:30AM
Innate Intracellular Antiviral Responses (Joint)
Room: Ballroom B, C

Speaker 4 of 6
* Stephen P. Goff, Columbia University, USA
Cellular Blocks to HIV and MuLV Infection

Thursday, April 15 | 8:00AM - 11:30AM
Innate Intracellular Antiviral Responses (Joint)
Room: Ballroom B, C

Speaker 5 of 6
Jonathan P. Stoye, Francis Crick Institute, UK
Fv1 and Related Retrovirus Restriction Genes

Thursday, April 15 | 8:00AM - 11:30AM
Innate Intracellular Antiviral Responses (Joint)
Room: Ballroom B, C

Speaker 6 of 6
Jaisri R. Lingappa, University of Washington, USA
HP68/RNase L Inhibitor: A Host Factor Critical for Virion Assembly

Thursday, April 15 | 9:20AM - 9:40AM
Coffee Break
Room: Grand Foyer


Thursday, April 15 | 11:00AM - 1:00PM
Poster Setup
Room: Ballroom A, Grand Foyer


Thursday, April 15 | 1:00PM - 10:00PM
Poster Viewing
Room: Ballroom A, Grand Foyer


Thursday, April 15 | 2:00PM - 4:00PM
Workshop 3: Mechanisms of Antibody-Mediated Neutralization a
nd Escape
Room: Ballroom B, C

Speaker 1 of 8
* John R. Mascola, NIAID, National Institutes of Health, USA

Thursday, April 15 | 2:00PM - 4:00PM
Workshop 3: Mechanisms of Antibody-Mediated Neutralization a
nd Escape
Room: Ballroom B, C

Speaker 2 of 8
Ruth A. McCaffrey, Seattle Biomedical Research Institute, USA
The Immunologically ‘Silent’ Face of gp120 Protects HIV-1 SF162 from Neutralization by Anti-gp120 and Anti-gp41 Antibodies

Thursday, April 15 | 2:00PM - 4:00PM
Workshop 3: Mechanisms of Antibody-Mediated Neutralization a
nd Escape
Room: Ballroom B, C

Speaker 3 of 8
Carol D. Weiss, US Food and Drug Administration, USA
Escaping Fusion Inhibition: Elusive Tactics of the HIV Envelope Glycoprotein

Thursday, April 15 | 2:00PM - 4:00PM
Workshop 3: Mechanisms of Antibody-Mediated Neutralization a
nd Escape
Room: Ballroom B, C

Speaker 4 of 8
Robert G. Whalen, Altravax, Inc., USA
Creating Improved Viral Immunogens by Directed Molecular Evolution

Thursday, April 15 | 2:00PM - 4:00PM
Workshop 3: Mechanisms of Antibody-Mediated Neutralization a
nd Escape
Room: Ballroom B, C

Speaker 5 of 8
Kelly A. Stefano Cole, University of Pittsburgh School of Medicine, USA
Characterization of Antibody Binding Properties Associated with Neutralization of SIV

Thursday, April 15 | 2:00PM - 4:00PM
Workshop 3: Mechanisms of Antibody-Mediated Neutralization a
nd Escape
Room: Ballroom B, C

Speaker 6 of 8
Ralph A. Pantophlet, Simon Fraser University, Canada
Immunofocusing: Re-Engineering Monomeric gp120 to Promote the Induction of HIV-Neutralizing Antibodies

Thursday, April 15 | 2:00PM - 4:00PM
Workshop 3: Mechanisms of Antibody-Mediated Neutralization a
nd Escape
Room: Ballroom B, C

Speaker 7 of 8
Cheryl A. Pikora, New England Regional Primate Research Center, USA
Persistence of Neutralization Resistance Despite Removal of gp120, Core, N-linked Glycosylation Sites in SIV239

Thursday, April 15 | 2:00PM - 4:00PM
Workshop 3: Mechanisms of Antibody-Mediated Neutralization a
nd Escape
Room: Ballroom B, C

Speaker 8 of 8
Miroslaw K. Gorny, New York University School of Medicine, USA
Identification of a New Neutralizing Epitope in gp120

Thursday, April 15 | 2:00PM - 4:00PM
Workshop 3: Neuro AIDS and Latency
This session is from HIV Pathogenesis
Room: Garibaldi A/B
Attendance Limited to 125
Speaker 1 of 9
* Janice E. Clements, Johns Hopkins University, USA


Thursday, April 15 | 2:00PM - 4:00PM
Workshop 3: Neuro AIDS and Latency
This session is from HIV Pathogenesis
Room: Garibaldi A/B
Attendance Limited to 125
Speaker 2 of 9
Paul R. Gorry, RMIT University, Australia
Longitudinal Analysis of nef/LTR-Deleted HIV-1 in Blood and CSF of a Long-Term Survivor who Developed HIV-Associated Dementia


Thursday, April 15 | 2:00PM - 4:00PM
Workshop 3: Neuro AIDS and Latency
This session is from HIV Pathogenesis
Room: Garibaldi A/B
Attendance Limited to 125
Speaker 3 of 9
Evelyne E. Schaeffer, Centre de Neurochimie, France
Role of the Envelope in HIV-1 Induced Direct Neuronal Cell Damage


Thursday, April 15 | 2:00PM - 4:00PM
Workshop 3: Neuro AIDS and Latency
This session is from HIV Pathogenesis
Room: Garibaldi A/B
Attendance Limited to 125
Speaker 4 of 9
Paul R. Clapham, University of Massachusetts Medical School, USA
Biological Analysis of HIV-1 R5 Envelopes Amplified by PCR from Brain and Lymph Node Tissue of AIDS Patients with Neuropathology


Thursday, April 15 | 2:00PM - 4:00PM
Workshop 3: Neuro AIDS and Latency
This session is from HIV Pathogenesis
Room: Garibaldi A/B
Attendance Limited to 125
Speaker 5 of 9
Justyna M. Dudaronek, Johns Hopkins School of Medicine, USA
Regulation of Viral Gene Expression in the CNS by Innate Immune Responses during Acute SIV Infection


Thursday, April 15 | 2:00PM - 4:00PM
Workshop 3: Neuro AIDS and Latency
This session is from HIV Pathogenesis
Room: Garibaldi A/B
Attendance Limited to 125
Speaker 6 of 9
Michael R. Nonnemacher, Drexel University College of Medicine, USA
An Enhanced Preference for a High Affinity Interaction between HIV-1 Vpr and Sequences within C/EBP Site I Correlates with HIV-1 Associated Dementia


Thursday, April 15 | 2:00PM - 4:00PM
Workshop 3: Neuro AIDS and Latency
This session is from HIV Pathogenesis
Room: Garibaldi A/B
Attendance Limited to 125
Speaker 7 of 9
Yefei Han, Johns Hopkins School of Medicine, USA
Latent HIV-1 Genomes Reside in Actively Transcribed Genes in Resting CD4+ T Cells in vivo


Thursday, April 15 | 2:00PM - 4:00PM
Workshop 3: Neuro AIDS and Latency
This session is from HIV Pathogenesis
Room: Garibaldi A/B
Attendance Limited to 125
Speaker 8 of 9
Samuel Ambler Williams, Gladstone Institute, USA
NF-kappaB/Rel Transcription Factors and the Regulation of HIV Postintegration Latency


Thursday, April 15 | 2:00PM - 4:00PM
Workshop 3: Neuro AIDS and Latency
This session is from HIV Pathogenesis
Room: Garibaldi A/B
Attendance Limited to 125
Speaker 9 of 9
Leor S. Weinberger, University of California, San Francisco, USA
Stochastic Switching in HIV-1 Tat Transactivation as a Possible Mechanism Leading to HIV-1 Proviral Latency


Thursday, April 15 | 4:30PM - 4:45PM
Coffee & Snacks Available
Room: Grand Foyer


Thursday, April 15 | 4:45PM - 7:00PM
HIV Genetic Variation (Joint)
Room: Ballroom B, C

Speaker 1 of 4
Francine McCutchan, PATH, USA
Molecular Epidemiology of the Global HIV-1 Pandemic

Thursday, April 15 | 4:45PM - 7:00PM
HIV Genetic Variation (Joint)
Room: Ballroom B, C

Speaker 2 of 4
* Bette Tina Marie Korber, Los Alamos National Laboratory, USA
Neutralization Antibody Signature Patterns in HIV Sequences

Thursday, April 15 | 4:45PM - 7:00PM
HIV Genetic Variation (Joint)
Room: Ballroom B, C

Speaker 3 of 4
Todd M. Allen, Ragon Institute of MGH, MIT and Harvard, USA
Short Talk: Stereotypic Escape from CD8T Cell Responses as a Major Driving Force of HIV-1 Sequence Evolution

Thursday, April 15 | 4:45PM - 7:00PM
HIV Genetic Variation (Joint)
Room: Ballroom B, C

Speaker 4 of 4
Dean H. Hamer, National Institutes of Health, USA
Short Talk: HIV-Specific CD4 T Cells are a Hot Spot for Viral Evolution

Thursday, April 15 | 7:00PM - 8:00PM
Social Hour
Room: Ballroom A, Grand Foyer


Thursday, April 15 | 7:30PM - 10:00PM
Poster Session 3
Room: Ballroom A, Grand Foyer


Friday, April 16 | 6:30AM - 8:00AM
Breakfast
Room: Lower Level


Friday, April 16 | 8:00AM - 11:20AM
Novel Approaches to HIV Vaccination
Room: Ballroom B

Speaker 1 of 7
Jeffrey D. Lifson, Leidos Biomedical Research, Inc., USA
Whole Inactivated AIDS Virus Virions with Functional Envelope Glycoproteins

Friday, April 16 | 8:00AM - 11:20AM
Novel Approaches to HIV Vaccination
Room: Ballroom B

Speaker 2 of 7
Richard W. Compans, Emory University, Rollins Research Center, USA
Virus-like Particles as HIV Immunogens

Friday, April 16 | 8:00AM - 11:20AM
Novel Approaches to HIV Vaccination
Room: Ballroom B

Speaker 3 of 7
* Norman L. Letvin, Beth Israel Deaconess Medical Center, USA
A Multi-Clade Envelope-Based Vaccine Strategy for HIV

Friday, April 16 | 8:00AM - 11:20AM
Novel Approaches to HIV Vaccination
Room: Ballroom B

Speaker 4 of 7
Stephen A. Udem, Wyeth Pharmaceuticals, USA
VSV as an HIV Vaccine Vector

Friday, April 16 | 8:00AM - 11:20AM
Novel Approaches to HIV Vaccination
Room: Ballroom B

Speaker 5 of 7
Hildegund C.J. Ertl, Wistar Institute, USA
Simian-Derived E1-Deleted Adenovirus Vectors for HIV Vaccination

Friday, April 16 | 8:00AM - 11:20AM
Novel Approaches to HIV Vaccination
Room: Ballroom B

Speaker 6 of 7
Dan H. Barouch, Beth Israel Deaconess Medical Center, USA
Short Talk: Low Seroprevalence of Adenovirus Serotype 35 and Immunogenicity of rAd35-Gag Vaccine in Mice with Pre-Existing Anti-Ad5 Immunity

Friday, April 16 | 8:00AM - 11:20AM
Novel Approaches to HIV Vaccination
Room: Ballroom B

Speaker 7 of 7
Adam C. Soloff, University of Pittsburgh, USA
Short Talk: Dual Adenoviral-Based Vaccination Using Serotypes 5 and 35 Induces Broad T Cell Responses to SIV which are Recalled with Heterologous Challenge

Friday, April 16 | 8:00AM - 11:00AM
Nef Function
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 1 of 5
John C. Guatelli, University of California, San Diego, USA
Nef, Intracellular Protein Trafficking, and Viral Infectivity


Friday, April 16 | 8:00AM - 11:00AM
Nef Function
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 2 of 5
* Kathleen L. Collins, University of Michigan Medical Center, USA
Nef-Mediated MHC-1 Downmodulation in T Cells


Friday, April 16 | 8:00AM - 11:00AM
Nef Function
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 3 of 5
Kalle Saksela, University of Helsinki, Finland
Cellular Activation by HIV-1 Accessory Proteins


Friday, April 16 | 8:00AM - 11:00AM
Nef Function
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 4 of 5
Andreas Stephan Baur, Germany
Nef Signaling in T Cells and HIV Replication: New Insights into the Molecular Mechanism


Friday, April 16 | 8:00AM - 11:00AM
Nef Function
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 5 of 5
Olivier Schwartz, Institut Pasteur, France
Role of HIV-1 Nef during Viral Replication in Primary Cells


Friday, April 16 | 9:20AM - 9:40AM
Coffee Break
Room: Grand Foyer


Friday, April 16 | 11:00AM - 1:00PM
Poster Setup
Room: Ballroom A, Grand Foyer


Friday, April 16 | 1:00PM - 10:00PM
Poster Viewing
Room: Ballroom A, Grand Foyer


Friday, April 16 | 2:00PM - 4:00PM
Workshop 4: HIV-Immune Evasion
Room: Ballroom B

Speaker 1 of 6
Marcus Altfeld, Heinrich-Pette-Institute, Germany
Selection, Transmission, and Reversion of an Antigen Processing CTL Escape Mutation in HIV-1

Friday, April 16 | 2:00PM - 4:00PM
Workshop 4: HIV-Immune Evasion
Room: Ballroom B

Speaker 2 of 6
Annika C. Karlsson, Karolinska Institutet, Sweden
Cellular Immune Responses and Viral Escape in HLA-A2-Positive Patients Following Primary HIV-1 Infection

Friday, April 16 | 2:00PM - 4:00PM
Workshop 4: HIV-Immune Evasion
Room: Ballroom B

Speaker 3 of 6
Sylvie Le Gall, Massachusetts General Hospital, Harvard Medical School, USA
An HLA B57-Specific Mutation Outside an Immunodominant Epitope Alters Antigen Processing and Leads to CTL Escape

Friday, April 16 | 2:00PM - 4:00PM
Workshop 4: HIV-Immune Evasion
Room: Ballroom B

Speaker 4 of 6
Todd M. Allen, Ragon Institute of MGH, MIT and Harvard, USA
CD8 T Cell Responses and Viral Escape in HIV-Infected Monozygotic Twins Infected with the Same Virus

Friday, April 16 | 2:00PM - 4:00PM
Workshop 4: HIV-Immune Evasion
Room: Ballroom B

Speaker 5 of 6
Astrid K.N. Iversen, Weatherall Institute of Molecular Medicine, UK
Functional and Structural Basis for HIV Escape from T Cell Recognition

Friday, April 16 | 2:00PM - 4:00PM
Workshop 4: HIV-Immune Evasion
Room: Ballroom B

Speaker 6 of 6
Wendy M. Blay, Seattle Biomedical Research Institute, USA
Potential N-Linked Glycosylation Sites Undergo Predictable Patterns of Variation within Constrained Regions of HIV-1 Envelope

Friday, April 16 | 2:00PM - 4:15PM
Workshop 4: HIV Entry, Early Events
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 1 of 10
* Didier Trono, Ecole Polytechnique Fédérale de Lausanne, Switzerland


Friday, April 16 | 2:00PM - 4:15PM
Workshop 4: HIV Entry, Early Events
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 2 of 10
Sophie Holuigue, Windeyer Institute of Medical Sciences, University College London, UK
Antibodies Capable of Inactivating HIV-1 Arise Coincidentally with the Initial Decline in Viral Load during acute Infection


Friday, April 16 | 2:00PM - 4:15PM
Workshop 4: HIV Entry, Early Events
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 3 of 10
Severine Bär, Deutsches Krebsforschungszentrum, germany
Dissecting Steps of gp41-Mediated Membrane Fusion by Quantitative
Assays Based on Flow Cytometry: Involvement of the Loop Region in Post Lipid Mixing Events


Friday, April 16 | 2:00PM - 4:15PM
Workshop 4: HIV Entry, Early Events
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 4 of 10
Ariberto Fassati, University College London, UK
Importin 7 Mediates Nuclear Import of HIV-1 Intracellular Reverse Transcription Complexes


Friday, April 16 | 2:00PM - 4:15PM
Workshop 4: HIV Entry, Early Events
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 5 of 10
Eric Poeschla, University of Colorado School of Medicine, USA
LEDGF/p75 Determines Cellular Trafficking of Diverse Lentiviral but not Oncoretroviral Integrase Proteins and is a Component of Functional HIV-1 Pre-Integration Complexes


Friday, April 16 | 2:00PM - 4:15PM
Workshop 4: HIV Entry, Early Events
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 6 of 10
Robert J. Gorelick, National Cancer Institute at Frederick, USA
Involvement of the HIV-1 Nucleocapsid Protein in the Synthesis and
Integration of the Viral DNA during Infection


Friday, April 16 | 2:00PM - 4:15PM
Workshop 4: HIV Entry, Early Events
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 7 of 10
Malini Mansharamani, Johns Hopkins School of Medicine, USA
Barrier-to-Autointegration Factor (BAF) Binds HIV-1 Gag and MA Proteins


Friday, April 16 | 2:00PM - 4:15PM
Workshop 4: HIV Entry, Early Events
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 8 of 10
Kelly M. Champagne, Thomas Jefferson University, USA
The Structure and Folding of a Designed HIV-1 Entry Inhibitor


Friday, April 16 | 2:00PM - 4:15PM
Workshop 4: HIV Entry, Early Events
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 9 of 10
Hugues J.P. Ryser, Boston University School of Medicine, USA
PDI-Mediated Reduction of Disulfide Bonds in Envelope Glycoprotein gp120 is Required for HIV-1 Entry


Friday, April 16 | 2:00PM - 4:15PM
Workshop 4: HIV Entry, Early Events
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 10 of 10
Alexa Raney, University of Texas Southwestern Medical Center, USA
In vitro Reconstitution of an Active Pak2/Nef Complex


Friday, April 16 | 4:30PM - 4:45PM
Coffee & Snacks Available
Room: Grand Foyer


Friday, April 16 | 4:45PM - 7:00PM
Therapeutic Vaccination of HIV-Infected Individuals
Room: Ballroom B

Speaker 1 of 4
Brigitte Autran, Hôpital Pitié-Salpétrière, UPMC, France
Therapeutic Immunization against HIV


Friday, April 16 | 4:45PM - 7:00PM
Therapeutic Vaccination of HIV-Infected Individuals
Room: Ballroom B

Speaker 2 of 4
Richard A. Koup, NIAID, National Institutes of Health, USA
Therapeutic Vaccines: Hypothesis Testing in vivo


Friday, April 16 | 4:45PM - 7:00PM
Therapeutic Vaccination of HIV-Infected Individuals
Room: Ballroom B

Speaker 3 of 4
* Nina Bhardwaj, Icahn School of Medicine at Mount Sinai, USA
Stimulating Cellular Immunity with Dendritic Cell Based Vaccines

Friday, April 16 | 4:45PM - 7:00PM
Therapeutic Vaccination of HIV-Infected Individuals
Room: Ballroom B

Speaker 4 of 4
Bruce D. Walker, Ragon Institute of MGH, MIT and Harvard, USA
Immunology and virology of controlled HIV infection


Friday, April 16 | 4:45PM - 7:00PM
NeuroAIDS
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 1 of 4
* Dana H. Gabuzda, Dana Farber Cancer Institute, USA
Mechanisms of Neuropathogenesis


Friday, April 16 | 4:45PM - 7:00PM
NeuroAIDS
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 2 of 4
Francisco González-Scarano, University of Texas Health Science Center at San Antonio, USA
Determinants of Microglial/Macrophage Tropism and Replication


Friday, April 16 | 4:45PM - 7:00PM
NeuroAIDS
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 3 of 4
Karl-Heinz Krause, University of Geneva Faculty of Medicine, Switzerland
HIV, CCR5, and Neurodegeneration


Friday, April 16 | 4:45PM - 7:00PM
NeuroAIDS
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 4 of 4
Andrew A. Lackner, Tulane National Primate Research Center, USA
Early Events in the Neuropathogenesis of AIDS


Friday, April 16 | 7:00PM - 8:00PM
Social Hour
Room: Ballroom A, Grand Foyer


Friday, April 16 | 7:30PM - 10:00PM
Poster Session 4
Room: Ballroom A, Grand Foyer


Saturday, April 17 | 6:30AM - 8:00AM
Breakfast
Room: Lower Level


Saturday, April 17 | 8:00AM - 11:00AM
Lessons for HIV Vaccine Development from other Vaccines
Room: Ballroom B

Speaker 1 of 5
William R. Jacobs, Jr., HHMI/Albert Einstein College of Medicine, USA
Novel Strategies for Vaccine Protection Against M. tuberculosis

Saturday, April 17 | 8:00AM - 11:00AM
Lessons for HIV Vaccine Development from other Vaccines
Room: Ballroom B

Speaker 2 of 5
* Kanta Subbarao, WHO Collaborating Centre for Reference and Research on Influenza, Australia
Preventing Pandemics and Newly Emerging Respiratory Viral Threats through Vaccine Development

Saturday, April 17 | 8:00AM - 11:00AM
Lessons for HIV Vaccine Development from other Vaccines
Room: Ballroom B

Speaker 3 of 5
Kathrin U. Jansen, Pfizer, USA
Status of Prophylatic Vaccines Against Cervical Cancer

Saturday, April 17 | 8:00AM - 11:00AM
Lessons for HIV Vaccine Development from other Vaccines
Room: Ballroom B

Speaker 4 of 5
Drew M. Pardoll, Johns Hopkins University School of Medicine, USA
Novel Vaccine Strategies for the Treatment of Cancer

Saturday, April 17 | 8:00AM - 11:00AM
Lessons for HIV Vaccine Development from other Vaccines
Room: Ballroom B

Speaker 5 of 5
Suzanne L. Topalian, Johns Hopkins University School of Medicine, USA
Immunotherapy of Cancer: Lessons Learned from Melanoma

Saturday, April 17 | 8:00AM - 11:00AM
HIV-1 in the Nucleus
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 1 of 5
Frederic D. Bushman, University of Pennsylvania, USA
DNA Integration by Retroviruses in the Human Genome


Saturday, April 17 | 8:00AM - 11:00AM
HIV-1 in the Nucleus
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 2 of 5
* Michael Emerman, Fred Hutchinson Cancer Research Center, USA
HIV Infection of Non-Dividing Cells


Saturday, April 17 | 8:00AM - 11:00AM
HIV-1 in the Nucleus
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 3 of 5
Katherine A. Jones, The Salk Institute, USA
The c-Ski-Interacting Protein (SKIP) Facilitates Transcription Elongation by HIV-1 Tat


Saturday, April 17 | 8:00AM - 11:00AM
HIV-1 in the Nucleus
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 4 of 5
Barbara K. Felber, NCI, National Institutes of Health, USA
HIV Posttranscriptional Regulation and Viral Latency


Saturday, April 17 | 8:00AM - 11:00AM
HIV-1 in the Nucleus
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 5 of 5
Eric M. Verdin, Buck Institute for Research on Aging, USA
Molecular Mechanisms of HIV Latency


Saturday, April 17 | 8:00AM - 12:00PM
Entertainment
Room: Ballroom A


Saturday, April 17 | 8:00AM - 12:00PM
Cash Bar
Room: Ballroom A


Saturday, April 17 | 9:20AM - 9:40AM
Coffee Break
Room: Grand Foyer


Saturday, April 17 | 4:30PM - 4:45PM
Coffee & Snacks Available
Room: Grand Foyer


Saturday, April 17 | 4:45PM - 7:00PM
Mechanisms of HIV Immune Evasion
Room: Ballroom B

Speaker 1 of 4
* George M. Shaw, University of Pennsylvania, USA
Immune Control and Escape by HIV-1: Neutralizing Antibodies

Saturday, April 17 | 4:45PM - 7:00PM
Mechanisms of HIV Immune Evasion
Room: Ballroom B

Speaker 2 of 4
Persephone Borrow, University of Oxford, UK
Escape of HIV-1 from the Primary CTL Response

Saturday, April 17 | 4:45PM - 7:00PM
Mechanisms of HIV Immune Evasion
Room: Ballroom B

Speaker 3 of 4
David I. Watkins, University of Miami, USA
SIV Escape from CTL

Saturday, April 17 | 4:45PM - 7:00PM
Mechanisms of HIV Immune Evasion
Room: Ballroom B

Speaker 4 of 4
Philip J. Goulder, University of Oxford, UK
HIV Evolution: CTL Escape Mutation and Reversion following Transmission

Saturday, April 17 | 4:45PM - 7:15PM
HIV-1 and Protein Trafficking in the Cytoplasm
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 1 of 6
* Beatrice H. Hahn, University of Pennsylvania, USA


Saturday, April 17 | 4:45PM - 7:15PM
HIV-1 and Protein Trafficking in the Cytoplasm
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 2 of 6
Mark Marsh, University College London, UK
HIV Assembly in the Endocytic Pathway


Saturday, April 17 | 4:45PM - 7:15PM
HIV-1 and Protein Trafficking in the Cytoplasm
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 3 of 6
Markus Thali, University of Vermont, USA
HIV-1 Egress is Gated Through Late Endosomal Membranes


Saturday, April 17 | 4:45PM - 7:15PM
HIV-1 and Protein Trafficking in the Cytoplasm
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 4 of 6
Ganjam V. Kalpana, Albert Einstein College of Medicine, USA
A Novel INI1/hSNF5 Associated HDAC1 Complex is Specifically Incorporated into HIV-1 Virions and is Required for Viral Early Events


Saturday, April 17 | 4:45PM - 7:15PM
HIV-1 and Protein Trafficking in the Cytoplasm
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 5 of 6
Benjamin K. Chen, Mount Sinai School of Medicine, USA
Chimeric Virus Models to Understand HIV-1 Assembly


Saturday, April 17 | 4:45PM - 7:15PM
HIV-1 and Protein Trafficking in the Cytoplasm
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 6 of 6
Paul D. Bieniasz, Rockefeller University, USA
GAG Localization and Interaction with Host Factors during Retrovirus Assembly and Budding


Saturday, April 17 | 7:00PM - 8:00PM
Social Hour
Room: Ballroom A


Sunday, April 18 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.