Web Desc
Molecular Targets for Cancer Therapy
Organizer(s): Sara A. Courtneidge and Frank McCormick
Date: January 06 - 11, 2005
Location: Eldorado Hotel & Spa, Santa Fe, NM, USA
Sponsored by Genentech, Inc. and Novartis Institutes for BioMedical Research
For important information on the coronavirus, please click here
Summary of Meeting:
Recent years have seen the approval of several targeted cancer therapeutics. For example, Herceptin (which targets Her2) is used for the treatment of some breast cancers, Gleevec (targeting Bcr-Abl and c-Kit) for chronic myelogenous leukemia and gastrointestinal stromal tumors, and Iressa (targeting the EGF receptor) for lung cancer. These new drugs highlight that we have entered an exciting era, in which cancer therapy involves identifying and targeting key molecular drivers of the disease. Yet many very important questions remain, including: Which are the best molecular targets? What is the role of combination therapy? And anti-angiogenesis therapy? Which animal models are most predictive of the human disease? Should we be targeting 'cancer stem cells'? The goal of this meeting is to bring together leaders from all areas of cancer research to discuss these issues surrounding the identification of new molecular targets, and the generation and testing of therapeutics directed against them.
Discounted Abstract Deadline: September 15 2004
Discounted Registration Deadline: November 8 2004
We gratefully acknowledge additional support for this conference from:
Cell Signaling Technology, Inc.Genentech, Inc.Novartis Institutes for BioMedical Research
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genentech, Inc.

Merck Research Laboratories
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13-CA112983-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Thursday, January 06 | 3:00PM - 7:30PM
Registration
Room: Zia Concourse


Thursday, January 06 | 6:30PM - 7:30PM
Refreshments
Room: Sunset Room


Thursday, January 06 | 7:30PM - 9:30PM
Keynote Session
Room: Anasazi Ballroom

Speaker 1 of 4
* Sara A. Courtneidge, Sanford-Burnham Medical Research Institute, USA

Thursday, January 06 | 7:30PM - 9:30PM
Keynote Session
Room: Anasazi Ballroom

Speaker 2 of 4
* Frank McCormick, University of California, San Francisco, USA

Thursday, January 06 | 7:30PM - 9:30PM
Keynote Session
Room: Anasazi Ballroom

Speaker 3 of 4
Mina J. Bissell, Lawrence Berkeley National Laboratory, USA
3-Dimensional Models of Cancer

Thursday, January 06 | 7:30PM - 9:30PM
Keynote Session
Room: Anasazi Ballroom

Speaker 4 of 4
Joan Massagué, Memorial Sloan Kettering Cancer Center, USA
TGF-beta and Cancer

Friday, January 07 | 7:00AM - 8:00AM
Breakfast
Room: Eldorado Court


Friday, January 07 | 8:00AM - 11:00AM
Mouse Models of Cancer. Session Sponsored by Genentech, Inc
.

Room: Anasazi Ballroom

Speaker 1 of 5
* Scott W. Lowe, Memorial Sloan Kettering Cancer Center, USA
Genetics of Drug Sensitivity and Resistance

Friday, January 07 | 8:00AM - 11:00AM
Mouse Models of Cancer. Session Sponsored by Genentech, Inc
.

Room: Anasazi Ballroom

Speaker 2 of 5
Irving L. Weissman, Stanford University, USA
Cancer Stem Cells


Friday, January 07 | 8:00AM - 11:00AM
Mouse Models of Cancer. Session Sponsored by Genentech, Inc
.

Room: Anasazi Ballroom

Speaker 3 of 5
Luis F. Parada, Memorial Sloan Kettering Cancer Center, USA
Tumors of the Nervous System

Friday, January 07 | 8:00AM - 11:00AM
Mouse Models of Cancer. Session Sponsored by Genentech, Inc
.

Room: Anasazi Ballroom

Speaker 4 of 5
Lynda Chin, University of Texas MD Anderson Cancer Center, USA
Inducible Onco-Transgene Models for Identification of Tumor Maintenance Targets

Friday, January 07 | 8:00AM - 11:00AM
Mouse Models of Cancer. Session Sponsored by Genentech, Inc
.

Room: Anasazi Ballroom

Speaker 5 of 5
Louise R. Howe, Weill-Cornell Medical College, USA
Short Talk: HER2/neu-Induced Mammary Tumorigenesis and Angiogenesis are Reduced in Cox-2-Deficient Mice

Friday, January 07 | 9:20AM - 9:40AM
Coffee Break
Room: Zia Concourse


Friday, January 07 | 11:00AM - 1:00PM
Poster Setup
Room: Sunset Room


Friday, January 07 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunset Room


Friday, January 07 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Zia Concourse


Friday, January 07 | 5:30PM - 7:00PM
Proliferation
Room: Anasazi Ballroom

Speaker 1 of 3
* Charles J. Sherr, St. Jude Children's Research Hospital, USA
Oncogene Suppression by Arf

Friday, January 07 | 5:30PM - 7:00PM
Proliferation
Room: Anasazi Ballroom

Speaker 2 of 3
Jeffrey Settleman, Pfizer, USA
Drug-Sensitive EGF Receptor Mutations in Human Lung Cancer

Friday, January 07 | 5:30PM - 7:00PM
Proliferation
Room: Anasazi Ballroom

Speaker 3 of 3
Spiros Linardopoulos, Breakthrough Breast Cancer Research Centre, UK
Short Talk: IkappaBalpha Phosphorylation by STK15 is Critical for NF-kappaB Activation

Friday, January 07 | 7:00PM - 8:00PM
Social Hour
Room: Eldorado Court/Sunset Room


Friday, January 07 | 7:30PM - 10:00PM
Poster Session 1
Room: Sunset Room


Saturday, January 08 | 7:00AM - 8:00AM
Breakfast
Room: Eldorado Court


Saturday, January 08 | 8:00AM - 11:00AM
Genomic and Proteomic Strategies
Room: Anasazi Ballroom

Speaker 1 of 5
Richard M. Caprioli, Vanderbilt University Medical Center, USA
New Proteomic Approaches

Saturday, January 08 | 8:00AM - 11:00AM
Genomic and Proteomic Strategies
Room: Anasazi Ballroom

Speaker 2 of 5
Elise C. Kohn, National Institutes of Health, USA
Proteomics: Application to Serum and Tissue Biomarkers

Saturday, January 08 | 8:00AM - 11:00AM
Genomic and Proteomic Strategies
Room: Anasazi Ballroom

Speaker 3 of 5
Michael Stratton, Wellcome Trust Sanger Institute, UK
Mutational Screens of the Protein Kinase Gene Family in Human Cancers

Saturday, January 08 | 8:00AM - 11:00AM
Genomic and Proteomic Strategies
Room: Anasazi Ballroom

Speaker 4 of 5
* René Bernards, Netherlands Cancer Institute, Netherlands
Identification of Novel Drug Targets through Loss of Function Genetic Screens

Saturday, January 08 | 8:00AM - 11:00AM
Genomic and Proteomic Strategies
Room: Anasazi Ballroom

Speaker 5 of 5
Britta Weigelt, Netherlands Cancer Institute, Netherlands
Short Talk: Breast Cancer Lymph Node Metastasis Involves Tumor-Specific Sets of ECM-Remodeling and Growth Factor Signaling Genes

Saturday, January 08 | 9:20AM - 9:40AM
Coffee Break
Room: Zia Concourse


Saturday, January 08 | 11:00AM - 1:00PM
Poster Setup
Room: Sunset Room


Saturday, January 08 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunset Room


Saturday, January 08 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Zia Concourse


Saturday, January 08 | 5:00PM - 7:00PM
Stem Cells
Room: Anasazi Ballroom

Speaker 1 of 4
* Tyler Jacks, Massachusetts Institute of Technology, USA
Lung Cancer


Saturday, January 08 | 5:00PM - 7:00PM
Stem Cells
Room: Anasazi Ballroom

Speaker 2 of 4
Fiona M. Watt, King's College London School of Medicine, UK
Epidermal Stem Cells

Saturday, January 08 | 5:00PM - 7:00PM
Stem Cells
Room: Anasazi Ballroom

Speaker 3 of 4
Cédric Blanpain, Universite Libre de Bruxelles, Belgium
The Skin Stem Cell Niche

Saturday, January 08 | 5:00PM - 7:00PM
Stem Cells
Room: Anasazi Ballroom

Speaker 4 of 4
Ugur Ozerdem, La Jolla Institute for Molecular Medicine, USA
Short Talk: Pericytes in Angiogenesis in Neurofibromatosis Type 1

Saturday, January 08 | 7:00PM - 8:00PM
Social Hour
Room: Eldorado Court/Sunset Room


Saturday, January 08 | 7:30PM - 10:00PM
Poster Session 2
Room: Sunset Room


Sunday, January 09 | 7:00AM - 8:00AM
Breakfast
Room: Eldorado Court


Sunday, January 09 | 8:00AM - 11:00AM
Apoptosis and Cell Cycle
Room: Anasazi Ballroom

Speaker 1 of 5
* Karen H. Vousden, Francis Crick Institute, UK
The p53 Tumor Suppressor Pathway

Sunday, January 09 | 8:00AM - 11:00AM
Apoptosis and Cell Cycle
Room: Anasazi Ballroom

Speaker 2 of 5
Craig B. Thompson, Memorial Sloan Kettering Cancer Center, USA
Signaling Pathways that Promote Survival/Death of Proliferating Cells

Sunday, January 09 | 8:00AM - 11:00AM
Apoptosis and Cell Cycle
Room: Anasazi Ballroom

Speaker 3 of 5
Gerard I. Evan, University of Cambridge, UK
Determining the Requirements for Tumor Maintenance in vivo

Sunday, January 09 | 8:00AM - 11:00AM
Apoptosis and Cell Cycle
Room: Anasazi Ballroom

Speaker 4 of 5
Charles L. Sawyers, Memorial Sloan-Kettering Cancer Center, USA
ABL Kinase Inhibitor Resistance in Chronic Myeloid Leukemia: Mechanisms and Potential Solutions

Sunday, January 09 | 8:00AM - 11:00AM
Apoptosis and Cell Cycle
Room: Anasazi Ballroom

Speaker 5 of 5
Mark R. Philips, New York University Cancer Institute, USA
Short Talk: A Farnesyl-Electrostatic Switch Regulates K-Ras Association with Mitochondria and Stimulates Apoptosis

Sunday, January 09 | 9:20AM - 9:40AM
Coffee Break
Room: Zia Concourse


Sunday, January 09 | 11:00AM - 1:00PM
Poster Setup
Room: Sunset Room


Sunday, January 09 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunset Room


Sunday, January 09 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Zia Concourse


Sunday, January 09 | 5:00PM - 7:00PM
Genomic Integrity/Epigenetic Mechanisms
Room: Anasazi Ballroom

Speaker 1 of 4
* Thea D. Tlsty, University of California, San Francisco, USA
Targeting Early Events in Cancer for Prevention


Sunday, January 09 | 5:00PM - 7:00PM
Genomic Integrity/Epigenetic Mechanisms
Room: Anasazi Ballroom

Speaker 2 of 4
Victoria M. Richon, Sanofi, USA
HDAC Inhibitors in the Clinic


Sunday, January 09 | 5:00PM - 7:00PM
Genomic Integrity/Epigenetic Mechanisms
Room: Anasazi Ballroom

Speaker 3 of 4
Carl Barrett, AstraZeneca, USA
Title to be Determined

Sunday, January 09 | 5:00PM - 7:00PM
Genomic Integrity/Epigenetic Mechanisms
Room: Anasazi Ballroom

Speaker 4 of 4
Debajit K. Biswas, Dana Farber Cancer Institute, USA
Short Talk: NF-kappaB Activation as a Target Directed Therapy for Estrogen Receptor-Negative Human Breast Cancers

Sunday, January 09 | 7:00PM - 8:00PM
Social Hour
Room: Eldorado Court/Sunset Room


Sunday, January 09 | 7:30PM - 10:00PM
Poster Session 3
Room: Sunset Room


Monday, January 10 | 7:00AM - 8:00AM
Breakfast
Room: Eldorado Court


Monday, January 10 | 8:00AM - 11:00AM
Angiogenesis and Metastasis
Room: Anasazi Ballroom

Speaker 1 of 5
* Joan S. Brugge, Harvard Medical School, USA
Use of a 3D Breast Epithelial Model to Investigate Signaling Pathways that Regulate Morphogenesis and Oncogenesis

Monday, January 10 | 8:00AM - 11:00AM
Angiogenesis and Metastasis
Room: Anasazi Ballroom

Speaker 2 of 5
Napoleone Ferrara, University of California, San Diego, USA
VEGF and Tumor Angiogenesis: Basic Science and Clinical Progress

Monday, January 10 | 8:00AM - 11:00AM
Angiogenesis and Metastasis
Room: Anasazi Ballroom

Speaker 3 of 5
Zena Werb, University of California, San Francisco, USA
Metalloproteases, Inflammation and Invasion during Tumor Progression

Monday, January 10 | 8:00AM - 11:00AM
Angiogenesis and Metastasis
Room: Anasazi Ballroom

Speaker 4 of 5
Sara A. Courtneidge, Sanford-Burnham Medical Research Institute, USA
The Roles of Src and its Substrate Fish in Tumor Cell Invasion

Monday, January 10 | 8:00AM - 11:00AM
Angiogenesis and Metastasis
Room: Anasazi Ballroom

Speaker 5 of 5
Pran K. Datta, Vanderbilt University Medical Center, USA
Short Talk: A Specific Inhibitor of TGF-beta Receptor Kinase, SB-431542, as a Potent Antitumor Agent for Advanced Human Cancers

Monday, January 10 | 9:20AM - 9:40AM
Coffee Break
Room: Zia Concourse


Monday, January 10 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Zia Concourse


Monday, January 10 | 5:00PM - 7:00PM
Alternative Strategies/New Developments
Room: Anasazi Ballroom

Speaker 1 of 4
Frank McCormick, University of California, San Francisco, USA
Adenoviruses as Therapeutics


Monday, January 10 | 5:00PM - 7:00PM
Alternative Strategies/New Developments
Room: Anasazi Ballroom

Speaker 2 of 4
Patrick Lee, Dalhousie University, Canada
Reovirus Oncolysis

Monday, January 10 | 5:00PM - 7:00PM
Alternative Strategies/New Developments
Room: Anasazi Ballroom

Speaker 3 of 4
* Michelle D. Garrett, ICR Sutton, UK
New Targets/Small Molecule Drugs Heading for the Clinic

Monday, January 10 | 5:00PM - 7:00PM
Alternative Strategies/New Developments
Room: Anasazi Ballroom

Speaker 4 of 4
Nathan T. Ihle, MD Anderson Cancer Center, USA
Short Talk: Potentiation of the Antitumor Activity of Iressa by PX-866 a Novel Inhibitor of Phosphoinositide-3-Kinase

Monday, January 10 | 7:00PM - 8:00PM
Social Hour
Room: Eldorado Court/Sunset Room


Monday, January 10 | 8:00PM - 11:00PM
Entertainment
Room: Eldorado Court/Sunset Room


Monday, January 10 | 8:00PM - 11:00PM
Cash Bar
Room: Eldorado Court/Sunset Room


Tuesday, January 11 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.