Web Desc
Innate Immunity to Pathogens
Organizer(s): Wayne M. Yokoyama, Christine A. Biron and Stefan H.E. Kaufmann
Date: January 08 - 13, 2005
Location: Sheraton Steamboat Resort, Steamboat Springs, Colorado, USA
Sponsored by Burroughs Wellcome Fund
For important information on the coronavirus, please click here
Summary of Meeting:
The innate immune response is critical to control of pathogens during the early phases of infection. Recent advances have elaborated the orchestrated series of events involving innate immune cells, cytokines, chemokines, and other effector molecules that are required to restrain virus, bacteria, and parasite growth and dissemination. The innate immune system also influences adaptive immune responses. This meeting will be organized around mechanistic themes that are found in innate immune responses to a wide variety of pathogens. Students, post-doctoral fellows, and investigators will benefit from learning about emerging concepts of innate immunity to pathogens that may be applicable to their own studies of immunity to other organisms, and will illuminate new areas for exploration.
Discounted Abstract Deadline: September 15 2004
Discounted Registration Deadline: November 8 2004
We gratefully acknowledge additional support for this conference from:
Burroughs Wellcome Fund
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Coley Pharmaceutical Group, Inc.

Dynavax Technologies Corporation
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1 U13 AI60000-01

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13-AI063644-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Saturday, January 08 | 3:00PM - 7:30PM
Registration
Room: Foyer


Saturday, January 08 | 6:30PM - 7:30PM
Refreshments
Room: Foyer


Saturday, January 08 | 7:30PM - 8:30PM
Keynote Address
Room: Storm Peak/Mt Werner

Speaker 1 of 1
Siamon Gordon, Chang Gung University / University of Oxford, UK
Innate Immune Recognition by Macrophages

Sunday, January 09 | 7:00AM - 8:00AM
Breakfast
Room: 3 Saddles/Sevens


Sunday, January 09 | 8:00AM - 11:00AM
Innate Immune Cytokine and Chemokine Responses
Room: Storm Peak/Mt Werner

Speaker 1 of 5
Christine A. Biron, Brown University, USA
Shaping Innate Cytokine Functions by Controlling Accessibility of STAT Signaling Pathways

Sunday, January 09 | 8:00AM - 11:00AM
Innate Immune Cytokine and Chemokine Responses
Room: Storm Peak/Mt Werner

Speaker 2 of 5
Erik Barton, Wake Forest University School of Medicine, USA
and

Sunday, January 09 | 8:00AM - 11:00AM
Innate Immune Cytokine and Chemokine Responses
Room: Storm Peak/Mt Werner

Speaker 3 of 5
Deborah J. Lenschow, Washington University School of Medicine, USA
New Roles for Interferons during Virus Infections and Approaches to IFN Mechanisms

Sunday, January 09 | 8:00AM - 11:00AM
Innate Immune Cytokine and Chemokine Responses
Room: Storm Peak/Mt Werner

Speaker 4 of 5
* Sankar Ghosh, Columbia University, USA
TLR11 and Urinary Tract Infections

Sunday, January 09 | 8:00AM - 11:00AM
Innate Immune Cytokine and Chemokine Responses
Room: Storm Peak/Mt Werner

Speaker 5 of 5
Jürg Tschopp, University of Lausanne, Switzerland
Activation of the Inflammasome by Muramyl-Dipeptide

Sunday, January 09 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Sunday, January 09 | 11:00AM - 1:00PM
Poster Setup
Room: Sunshine Peak


Sunday, January 09 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunshine Peak


Sunday, January 09 | 2:00PM - 4:00PM
Workshop 1: Cellular Responses to Pathogens
Room: Storm Peak/Mt Werner

Speaker 1 of 8
* Christine A. Biron, Brown University, USA

Sunday, January 09 | 2:00PM - 4:00PM
Workshop 1: Cellular Responses to Pathogens
Room: Storm Peak/Mt Werner

Speaker 2 of 8
Roi Gazit, Hebrew University of Jerusalem, Israel
Influenza Infection is Lethal in NKp46 Knockout Mice

Sunday, January 09 | 2:00PM - 4:00PM
Workshop 1: Cellular Responses to Pathogens
Room: Storm Peak/Mt Werner

Speaker 3 of 8
Eric C. Mossel, Colorado State University, USA
IFN-beta And IFN-gamma Synergistically Inhibit the Replication of SARS-Coronavirus

Sunday, January 09 | 2:00PM - 4:00PM
Workshop 1: Cellular Responses to Pathogens
Room: Storm Peak/Mt Werner

Speaker 4 of 8
Mark T. Orr, Infectious Disease Research Institute, USA
MyD88 and TLR9-Mediated Immunity to Herpes Simplex Virus

Sunday, January 09 | 2:00PM - 4:00PM
Workshop 1: Cellular Responses to Pathogens
Room: Storm Peak/Mt Werner

Speaker 5 of 8
Andre Boonstra, Erasmus Medical Center, Netherlands
Endogenous IL-10 Profoundly Inhibits IL-12p70 Production upon TLR Ligation by Bone Marrow-derived Myeloid and Splenic Dendritic Cells, but not Plasmacytoid Precursor Dendritic Cells

Sunday, January 09 | 2:00PM - 4:00PM
Workshop 1: Cellular Responses to Pathogens
Room: Storm Peak/Mt Werner

Speaker 6 of 8
Franck Housseau, Johns Hopkins School of Medicine, USA
A Murine type I IFN-producing Cell Subset is Endowed with Natural Killing and Antigen Presenting Functions upon TLR-9 Activation

Sunday, January 09 | 2:00PM - 4:00PM
Workshop 1: Cellular Responses to Pathogens
Room: Storm Peak/Mt Werner

Speaker 7 of 8
Mitsutoshi Yoneyama, Tokyo Metropolitan Institute of Medical Science, Japan
The CARD-Containing DExD/H Box RNA Helicase, RIG-I, Plays an Essential Role in Innate Antiviral Responses

Sunday, January 09 | 2:00PM - 4:00PM
Workshop 1: Cellular Responses to Pathogens
Room: Storm Peak/Mt Werner

Speaker 8 of 8
Anasuya Sarkar, Ohio State University, USA
ASC is a Dual Regulator in Caspase-1 Mediated Inflammation and NF-kappaB Activation

Sunday, January 09 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Foyer


Sunday, January 09 | 5:00PM - 7:00PM
Effector Molecules in Innate Immunity
Room: Storm Peak/Mt Werner

Speaker 1 of 3
Alberto Mantovani, Humanitas University, Italy
The Long Pentraxin PTX3 In Antimicrobial Innate Immunity

Sunday, January 09 | 5:00PM - 7:00PM
Effector Molecules in Innate Immunity
Room: Storm Peak/Mt Werner

Speaker 2 of 3
Arturo Zychlinsky, Max Planck Institute for Infection Biology, Germany
Neutrophils Release Extracellular Structures against Bacteria

Sunday, January 09 | 5:00PM - 7:00PM
Effector Molecules in Innate Immunity
Room: Storm Peak/Mt Werner

Speaker 3 of 3
* Elena A. Levashina, Max Planck Institute for Infection Biology, Germany
Complement-Like Proteins in Mosquito Innate Immunity and Malaria Infections

Sunday, January 09 | 7:00PM - 8:00PM
Social Hour
Room: Foyer


Sunday, January 09 | 7:30PM - 10:00PM
Poster Session 1
Room: Sunshine Peak


Monday, January 10 | 7:00AM - 8:00AM
Breakfast
Room: 3 Saddles/Sevens


Monday, January 10 | 8:00AM - 11:00AM
Innate Intracellular Responses
Room: Storm Peak/Mt Werner

Speaker 1 of 4
Anthony W. Segal, University College London, UK
The Function of the Neutrophil NADPH Oxidase is to Induce K+ and Cl- Fluxes across the Membrane of the Phagocytic Vacuole, thereby Activating Granule Enzymes to Kill and Digest Microbes

Monday, January 10 | 8:00AM - 11:00AM
Innate Intracellular Responses
Room: Storm Peak/Mt Werner

Speaker 2 of 4
Luke A. J. O'Neill, Trinity Biomedical Sciences Institute, Ireland
Toll-Like Receptor Signal Transduction

Monday, January 10 | 8:00AM - 11:00AM
Innate Intracellular Responses
Room: Storm Peak/Mt Werner

Speaker 3 of 4
* Arthur M. Krieg, Checkmate Pharmaceuticals, USA
G/U-rich RNAs, CpGs, TLRs, and Anti-Viral Defense

Monday, January 10 | 8:00AM - 11:00AM
Innate Intracellular Responses
Room: Storm Peak/Mt Werner

Speaker 4 of 4
Franck J. Barrat, Hospital for Special Surgery, USA
Oligonucleotide-Based Inhibitors of Toll-Like Receptors -7, -8 and -9 and their Potential for the Treatment of Systemic Lupus Erythematosis

Monday, January 10 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Monday, January 10 | 11:00AM - 12:00PM
Poster Setup
Room: Sunshine Peak


Monday, January 10 | 11:00AM - 12:00PM
Lunch
Room: Sunshine Peak


Monday, January 10 | 11:30AM - 2:00PM
Poster Session 2
Room: Sunshine Peak


Monday, January 10 | 2:00PM - 4:00PM
Workshop 2: Recognition of Pathogens and Regulation of Host
Responses
Room: Storm Peak/Mt Werner

Speaker 1 of 8
* Gordon D. Brown, University of Aberdeen, UK
Short Talk: Dectin-1 Immunobiology

Monday, January 10 | 2:00PM - 4:00PM
Workshop 2: Recognition of Pathogens and Regulation of Host
Responses
Room: Storm Peak/Mt Werner

Speaker 2 of 8
Robert T. Wheeler, Whitehead Institute for Biomedical Research, USA
Innate Immune Recognition of Fungal Pathogens

Monday, January 10 | 2:00PM - 4:00PM
Workshop 2: Recognition of Pathogens and Regulation of Host
Responses
Room: Storm Peak/Mt Werner

Speaker 3 of 8
Jennifer Philips, Washington University School of Medicine, USA
Genome-Wide RNAi Screen in Drosophila Identifies a CD36 Family Member Required for Mycobacterial Infection

Monday, January 10 | 2:00PM - 4:00PM
Workshop 2: Recognition of Pathogens and Regulation of Host
Responses
Room: Storm Peak/Mt Werner

Speaker 4 of 8
Jin Seon S. Im, MD Anderson Cancer Center, USA
A Novel Mechanism for Modulation of CD1d-restricted NK T Cell Functions by Th2 Cytokine Skewing alpha Galactosyl Ceramide Analogs

Monday, January 10 | 2:00PM - 4:00PM
Workshop 2: Recognition of Pathogens and Regulation of Host
Responses
Room: Storm Peak/Mt Werner

Speaker 5 of 8
Masahiro Yamamoto, Osaka University, Japan
An Inducible Nuclear Protein, I kappa B zeta Regulates TLR-Mediated Gene Expression in a Two-Step Fashion

Monday, January 10 | 2:00PM - 4:00PM
Workshop 2: Recognition of Pathogens and Regulation of Host
Responses
Room: Storm Peak/Mt Werner

Speaker 6 of 8
Ashley Mansell, Monash Institute of Medical Research, Australia
SOCS-1 Targets Mal/TIRAP for Degradation to Regulate TLR-mediated Signaling.

Monday, January 10 | 2:00PM - 4:00PM
Workshop 2: Recognition of Pathogens and Regulation of Host
Responses
Room: Storm Peak/Mt Werner

Speaker 7 of 8
Senad Divanovic, Cincinnati Children's Hospital Medical Center, USA
Negative Regulation of TLR4 Signaling by RP105

Monday, January 10 | 2:00PM - 4:00PM
Workshop 2: Recognition of Pathogens and Regulation of Host
Responses
Room: Storm Peak/Mt Werner

Speaker 8 of 8
Kui Li, University of Texas Medical Branch, USA
Hepatitis C Virus NS3/4A Protease Limits TLR3-Mediated Antiviral Signaling by Specifically Targeting its Adaptor Protein, TRIF, for Proteolysis

Monday, January 10 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Foyer


Monday, January 10 | 5:00PM - 7:00PM
Viral and Microbial Interactions with Innate Immune Cells I
Room: Storm Peak/Mt Werner

Speaker 1 of 2
Stefanie N. Vogel, University of Maryland, USA
Innate Immune Responses to Microbes Initiated by Toll-Like Receptors

Monday, January 10 | 5:00PM - 7:00PM
Viral and Microbial Interactions with Innate Immune Cells I
Room: Storm Peak/Mt Werner

Speaker 2 of 2
* Marian R. Neutra, Children's Hospital Boston, USA
Innate Immunity in Organized Mucosal Lymphoid Tissues: Collaboration of Epithelial and Dendritic Cells

Tuesday, January 11 | 7:00AM - 8:00AM
Breakfast
Room: 3 Saddles/Sevens


Tuesday, January 11 | 8:00AM - 11:00AM
Viral and Microbial Interactions with Innate Immune Cells II
Room: Storm Peak/Mt Werner

Speaker 1 of 4
Dana Philpott, University of Toronto, Canada
NOD Proteins and Bacterial Infections

Tuesday, January 11 | 8:00AM - 11:00AM
Viral and Microbial Interactions with Innate Immune Cells II
Room: Storm Peak/Mt Werner

Speaker 2 of 4
Olivier Lantz, Institut Curie, France
Mucosal-Associated Invariant T (MAIT) Cell Selection

Tuesday, January 11 | 8:00AM - 11:00AM
Viral and Microbial Interactions with Innate Immune Cells II
Room: Storm Peak/Mt Werner

Speaker 3 of 4
Albert S. Bendelac, University of Chicago, USA
CD1-Restricted NKT Cells in Innate Recognition


Tuesday, January 11 | 8:00AM - 11:00AM
Viral and Microbial Interactions with Innate Immune Cells II
Room: Storm Peak/Mt Werner

Speaker 4 of 4
* Alan Sher, NIAID, National Institutes of Health, USA
Parasites Trigger Dendritic Cells to Activate and Polarize CD4 +T Cells by Two Distinct Pathways

Tuesday, January 11 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Tuesday, January 11 | 11:00AM - 1:00PM
Poster Setup
Room: Sunshine Peak


Tuesday, January 11 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunshine Peak


Tuesday, January 11 | 2:00PM - 4:00PM
Workshop 3: Host-Pathogen Interactions
Room: Storm Peak/Mt Werner

Speaker 1 of 9
* Stefan H. E. Kaufmann, Max Planck Institute for Infection Biology, Berlin, Germany

Tuesday, January 11 | 2:00PM - 4:00PM
Workshop 3: Host-Pathogen Interactions
Room: Storm Peak/Mt Werner

Speaker 2 of 9
Abdul Basit, Yale, USA
Essential Role of ICAM-1 and LFA-1 in LPS-Induced Neutrophil Recruitment into the Alveolar Space

Tuesday, January 11 | 2:00PM - 4:00PM
Workshop 3: Host-Pathogen Interactions
Room: Storm Peak/Mt Werner

Speaker 3 of 9
Krischan J. Hudson, University of Virginia, USA
Distinct beta 1 Integrin-binding Mechanisms of Yersinia pseudotuberculosis Adhesins Differentially Regulate Phagocytic Signaling Events in Macrophages

Tuesday, January 11 | 2:00PM - 4:00PM
Workshop 3: Host-Pathogen Interactions
Room: Storm Peak/Mt Werner

Speaker 4 of 9
Werner Solbach, University of Luebeck, Germany
Chlamydia pneumoniae Multiply in Neutrophil Granulocytes and Delay their Spontaneous Apoptosis

Tuesday, January 11 | 2:00PM - 4:00PM
Workshop 3: Host-Pathogen Interactions
Room: Storm Peak/Mt Werner

Speaker 5 of 9
Katherine C. Brittingham, US Army Medical Research Institute of Infectious Diseases, USA
Dendritic Cell Uptake of Bacillus anthracis Spores: Implications for Anthrax Pathogenesis

Tuesday, January 11 | 2:00PM - 4:00PM
Workshop 3: Host-Pathogen Interactions
Room: Storm Peak/Mt Werner

Speaker 6 of 9
Sergio Lopez-Briones, Universidad de Guanajuato, Mexico
Identification and Characterization of a Novel CD8 alpha beta + TCR gamma delta + iIEL Subset that Expands following Enteric Bacterial Infection

Tuesday, January 11 | 2:00PM - 4:00PM
Workshop 3: Host-Pathogen Interactions
Room: Storm Peak/Mt Werner

Speaker 7 of 9
Rebekah T. Taylor, Emory University, USA
The Role of Enteric Flora-Stimulated TLR Signaling in the Maturation of Isolated Lymphoid Follicles (ILF) in the Murine Small Intestine

Tuesday, January 11 | 2:00PM - 4:00PM
Workshop 3: Host-Pathogen Interactions
Room: Storm Peak/Mt Werner

Speaker 8 of 9
Christine McDonald, Cleveland Clinic, USA
Identification of a Novel Regulator of Nod2 Signaling

Tuesday, January 11 | 2:00PM - 4:00PM
Workshop 3: Host-Pathogen Interactions
Room: Storm Peak/Mt Werner

Speaker 9 of 9
Heidi Cheung, University of Toronto, Canada
AcPL is Essential for IL-18-Mediated Signaling

Tuesday, January 11 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Foyer


Tuesday, January 11 | 5:00PM - 7:00PM
Innate Immune Evasion by Pathogens
Room: Storm Peak/Mt Werner

Speaker 1 of 4
* Wayne M. Yokoyama, Washington University School of Medicine, USA
Natural Killer Cell Control of Viral Infection

Tuesday, January 11 | 5:00PM - 7:00PM
Innate Immune Evasion by Pathogens
Room: Storm Peak/Mt Werner

Speaker 2 of 4
Anthony R. French, Washington University, USA
Short Talk: Escape of Mutan Double Strad DIVA Virus from NIC cell Medicated Control

Tuesday, January 11 | 5:00PM - 7:00PM
Innate Immune Evasion by Pathogens
Room: Storm Peak/Mt Werner

Speaker 3 of 4
Stipan Jonjic, University of Rijeka, Faculty of Medicine, Croatia
Multiple Strategies to Evade NKG2D by MCMV

Tuesday, January 11 | 5:00PM - 7:00PM
Innate Immune Evasion by Pathogens
Room: Storm Peak/Mt Werner

Speaker 4 of 4
David H. Margulies, National Institutes of Health, USA
Short Talk: X-Ray Crystallographic Structure of the Murine Cytomegalovirus Immuno-Evasion MHC-1 Homolog m144: A Disordered Region Suggests a Natural Killer (NK) Cell Recognition Site

Tuesday, January 11 | 7:00PM - 8:00PM
Social Hour
Room: Foyer


Tuesday, January 11 | 7:30PM - 10:00PM
Poster Session 3
Room: Sunshine Peak


Wednesday, January 12 | 7:00AM - 8:00AM
Breakfast
Room: 3 Saddles/Sevens


Wednesday, January 12 | 8:00AM - 11:00AM
Innate Control of Acquired Immunity I
Room: Storm Peak/Mt Werner

Speaker 1 of 4
Laurence Zitvogel, Institut Gustave Roussy, France
Regulation of NK Cell Priming by Dendritic Cells

Wednesday, January 12 | 8:00AM - 11:00AM
Innate Control of Acquired Immunity I
Room: Storm Peak/Mt Werner

Speaker 2 of 4
Federica Sallusto, Università della Svizzera Italiana & ETH Zurich, Switzerland
Control of T Cell Immunity by Dendritic Cells

Wednesday, January 12 | 8:00AM - 11:00AM
Innate Control of Acquired Immunity I
Room: Storm Peak/Mt Werner

Speaker 3 of 4
Jonathan Sprent, Garvan Institute, Australia
Innate Control of Memory T Cell Responses


Wednesday, January 12 | 8:00AM - 11:00AM
Innate Control of Acquired Immunity I
Room: Storm Peak/Mt Werner

Speaker 4 of 4
* Bana Jabri, University of Chicago, USA
IL-15 and NKG2 Receptors: Linking Adaptive and Innate Immunity

Wednesday, January 12 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Wednesday, January 12 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Foyer


Wednesday, January 12 | 5:00PM - 7:00PM
Innate Control of Acquired Immunity II
Room: Storm Peak/Mt Werner

Speaker 1 of 3
Thomas A. Wynn, Pfizer, USA
Role of IL-13 Receptor alpha 2 in Innate Control of Acquired Immunity

Wednesday, January 12 | 5:00PM - 7:00PM
Innate Control of Acquired Immunity II
Room: Storm Peak/Mt Werner

Speaker 2 of 3
* Richard M. Locksley, HHMI/University of California, San Francisco, USA
Activating the Components of Type 2 Immunity

Wednesday, January 12 | 5:00PM - 7:00PM
Innate Control of Acquired Immunity II
Room: Storm Peak/Mt Werner

Speaker 3 of 3
Stefan H. E. Kaufmann, Max Planck Institute for Infection Biology, Berlin, Germany
Innate Response to Mycobacteria and Control of Acquired Immunity


Wednesday, January 12 | 7:00PM - 8:00PM
Social Hour
Room: Foyer


Wednesday, January 12 | 8:00PM - 11:00PM
Entertainment
Room: Sunshine Peak


Wednesday, January 12 | 8:00PM - 11:00PM
Cash Bar
Room: Sunshine Peak


Thursday, January 13 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.