Web Desc
Translational Medicine in Autoimmunity
Organizer(s): Lloyd H. Kasper, David A. Hafler and Lucienne Chatenoud
Date: January 08 - 13, 2005
Location: Big Sky Resort, Big Sky, MT, USA
Supported by The Director's Fund
Summary of Meeting:
Recent advances in the understanding of basic mechanisms of autoimmune disease have led to the development of reagents that can potentially interfere with the disease process and limit disease progression. Some of these therapeutics have already been proven effective in the treatment of autoimmune conditions. This meeting will focus on the use of novel therapeutics for the treatment and management of several autoimmune diseases including multiple sclerosis, inflammatory bowel disease, diabetes, systemic lupus and rheumatoid arthritis. Information will be presented that highlights new findings that 'bridge' the gap between bench and bedside. Particular emphasis will be placed on the translational therapeutics between pre-clinical and Phase I/II research. This will include such topics as blocking of co-stimulation, T cell trafficking, Th1 cytokine production (IL-12 and IL-23), T cell receptor vaccination, islet cell transplantation, chemokine antagonists and signal transduction pathway inhibitors. The application of these novel approaches to specific disease process will be examined and will provide insight into clinical disease management.
Discounted Abstract Deadline: September 16 2004
Discounted Registration Deadline: November 8 2004
We gratefully acknowledge additional support for this conference from:
CrohnJDRFNational Multiple Sclerosis SocietyNovartis Institutes for BioMedical Research
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Biogen Idec
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13-AI063786-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Saturday, January 08 | 3:00PM - 7:30PM
Registration
Room: Lower Atrium


Saturday, January 08 | 6:30PM - 7:30PM
Refreshments
Room: Lower Atrium


Saturday, January 08 | 7:30PM - 8:30PM
Keynote Address
Room: Jefferson

Speaker 1 of 1
Ravinder Maini, Imperial College London, UK
Biological and Clinical Lessons Learned from TNF Blockade in Man

Sunday, January 09 | 7:00AM - 8:00AM
Breakfast
Room: Madison/Gallatin


Sunday, January 09 | 8:00AM - 11:00AM
Immunmodulation in Diabetes
Room: Jefferson

Speaker 1 of 5
Megan Sykes, Massachusetts General Hospital, USA
Induction of Allotolerance and Reversal of Autoimmune Diabetes via Mixed Chimerism

Sunday, January 09 | 8:00AM - 11:00AM
Immunmodulation in Diabetes
Room: Jefferson

Speaker 2 of 5
Matthias G. von Herrath, Novo Nordisk and La Jolla Institute for Allergy and Immunology, USA
Viral Infections can Abrogate Autoimmunity by Inducing Apoptosis of Autoaggressive T Cells

Sunday, January 09 | 8:00AM - 11:00AM
Immunmodulation in Diabetes
Room: Jefferson

Speaker 3 of 5
* Jeffrey A. Bluestone, University of California, San Francisco, USA
Immune Regulation in Diabetes - Balancing the Good with the Bad

Sunday, January 09 | 8:00AM - 11:00AM
Immunmodulation in Diabetes
Room: Jefferson

Speaker 4 of 5
George S. Eisenbarth, University of Colorado Health Sciences Center, USA
Prediction of Organ Specific Autoimmunity

Sunday, January 09 | 8:00AM - 11:00AM
Immunmodulation in Diabetes
Room: Jefferson

Speaker 5 of 5
Manuela Battaglia, TIGET, Telethon Institute for Gene Therapy, Italy
Short Talk: Rapamycin and IL-10 Block Diabetes and Induce Long Term Tolerance in NOD Mice via both CD4+CD25+ Tr and Tr1 Cells

Sunday, January 09 | 9:20AM - 9:40AM
Coffee Break
Room: Lower Atrium


Sunday, January 09 | 11:00AM - 1:00PM
Poster Setup
Room: Madison/Gallatin


Sunday, January 09 | 1:00PM - 10:00PM
Poster Viewing
Room: Madison/Gallatin


Sunday, January 09 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Lower Atrium


Sunday, January 09 | 5:00PM - 7:00PM
Peptide Blocking and Prevention of Autoimmunity
Room: Jefferson

Speaker 1 of 3
* Stephen D. Miller, Northwestern University Medical School, USA
Treatment of Established Relapsing EAE Using Peptide-Specific Tolerance: Cellular and Molecular Mechanisms

Sunday, January 09 | 5:00PM - 7:00PM
Peptide Blocking and Prevention of Autoimmunity
Room: Jefferson

Speaker 2 of 3
Jan D. Lünemann, University Hospital Zurich, Switzerland
Short Talk: Ubiquitous Viruses Activate Cerebrospinal Fluid T Cell Clones in Multiple Sclerosis

Sunday, January 09 | 5:00PM - 7:00PM
Peptide Blocking and Prevention of Autoimmunity
Room: Jefferson

Speaker 3 of 3
Lawrence Steinman, Stanford University, USA
Antigen Specific Therapy of Autoimmune Disease: DNA Vaccines and APL Therapy in Humans with MS and IDDM

Sunday, January 09 | 7:00PM - 8:00PM
Social Hour
Room: Madison/Gallatin


Sunday, January 09 | 7:30PM - 10:00PM
Poster Session 1
Room: Madison/Gallatin


Monday, January 10 | 7:00AM - 8:00AM
Breakfast
Room: Madison/Gallatin


Monday, January 10 | 8:00AM - 11:00AM
Therapeutic Intervention in Multiple Sclerosis
Room: Jefferson

Speaker 1 of 5
Samia J. Khoury, Brigham and Women's Hospital, USA
Costimulatory Signal Blockade from Bench to Bedside

Monday, January 10 | 8:00AM - 11:00AM
Therapeutic Intervention in Multiple Sclerosis
Room: Jefferson

Speaker 2 of 5
Randolph J. Noelle, Dartmouth College, USA
Dendritic Cells as Targets in MS

Monday, January 10 | 8:00AM - 11:00AM
Therapeutic Intervention in Multiple Sclerosis
Room: Jefferson

Speaker 3 of 5
Howard L. Weiner, Brigham and Women’s Hospital, Harvard Medical School, USA
Oral Tolerance in MS


Monday, January 10 | 8:00AM - 11:00AM
Therapeutic Intervention in Multiple Sclerosis
Room: Jefferson

Speaker 4 of 5
Amit Bar-Or, University of Pennsylvania, USA
Impact of MS Therapies on Immune-Neural Interactions

Monday, January 10 | 8:00AM - 11:00AM
Therapeutic Intervention in Multiple Sclerosis
Room: Jefferson

Speaker 5 of 5
* Lloyd H. Kasper, Geisel School of Medicine at Dartmouth, USA
Short Talk: Blocking the IL-12/23p40 Cytokine Pathway in Multiple Sclerosis

Monday, January 10 | 9:20AM - 9:40AM
Coffee Break
Room: Lower Atrium


Monday, January 10 | 11:15AM - 1:00PM
Poster Setup
Room: Madison/Gallatin


Monday, January 10 | 1:00PM - 10:00PM
Poster Viewing
Room: Madison/Gallatin


Monday, January 10 | 3:30PM - 5:00PM
Workshop 1: Selected Oral Abstracts
Room: Jefferson

Speaker 1 of 8
* Stephen L. Hauser, University of California, San Francisco, USA

Monday, January 10 | 3:30PM - 5:00PM
Workshop 1: Selected Oral Abstracts
Room: Jefferson

Speaker 2 of 8
* Samia J. Khoury, Brigham and Women's Hospital, USA

Monday, January 10 | 3:30PM - 5:00PM
Workshop 1: Selected Oral Abstracts
Room: Jefferson

Speaker 3 of 8
James Varani, University of Michigan, USA
In vitro Approach to the Preclinical Assessment of Potential Therapeutics for Psoriasis

Monday, January 10 | 3:30PM - 5:00PM
Workshop 1: Selected Oral Abstracts
Room: Jefferson

Speaker 4 of 8
Paul W. Thompson, GlaxoSmithKline, UK
IL-10 is a PPAR-gamma Target Gene

Monday, January 10 | 3:30PM - 5:00PM
Workshop 1: Selected Oral Abstracts
Room: Jefferson

Speaker 5 of 8
Richard H. Scheuermann, J. Craig Venter Institute, USA
Immunology Data Integration through the ImmPort Data Model

Monday, January 10 | 3:30PM - 5:00PM
Workshop 1: Selected Oral Abstracts
Room: Jefferson

Speaker 6 of 8
Emma L. Masteller, Inovio Pharmaceuticals, USA
Therapeutic Potential of Endogenous Islet-Specific CD4+CD25+ Foxp3+ Regulatory T Cells Expanded from Nonobese Diabetic Mice

Monday, January 10 | 3:30PM - 5:00PM
Workshop 1: Selected Oral Abstracts
Room: Jefferson

Speaker 7 of 8
Laurie A. Minns, GlaxoSmithKline-Biologicals, USA
A Single Zwitterionic Polysaccharide from Bacteroides fragilis Prevents T. gondii-Induced Th1 Ileitis

Monday, January 10 | 3:30PM - 5:00PM
Workshop 1: Selected Oral Abstracts
Room: Jefferson

Speaker 8 of 8
Michael R. Ehrenstein, University College London, UK
Characterization of Regulatory T Cells in Rheumatoid Arthritis Before and After Treatment with Anti-TNFalpha Therapy

Monday, January 10 | 5:00PM - 5:30PM
Coffee & Snacks Available
Room: Lower Atrium


Monday, January 10 | 5:00PM - 7:00PM
B Cell Disruption in Autoimmunity
Room: Jefferson

Speaker 1 of 4
* Stephen L. Hauser, University of California, San Francisco, USA
Blocking B Cell Function

Monday, January 10 | 5:00PM - 7:00PM
B Cell Disruption in Autoimmunity
Room: Jefferson

Speaker 2 of 4
Jonathan C.W. Edwards, University College London, UK
Depleting B Cells in Rheumatoid Arthritis

Monday, January 10 | 5:00PM - 7:00PM
B Cell Disruption in Autoimmunity
Room: Jefferson

Speaker 3 of 4
Yulia Vugmeyster, Genentech, Inc., USA
Short Talk: Characterization of BR3-Fc-Mediated B-Cell Reduction in Cynomolgus Monkeys

Monday, January 10 | 5:00PM - 7:00PM
B Cell Disruption in Autoimmunity
Room: Jefferson

Speaker 4 of 4
Loren D. Erickson, Dartmouth Medical School, USA
Short Talk: B Cell Receptor Affinity is a Determinant in B Cell Lifespan and Fate

Monday, January 10 | 7:00PM - 8:00PM
Social Hour
Room: Madison/Gallatin


Monday, January 10 | 7:30PM - 10:00PM
Poster Session 2
Room: Madison/Gallatin


Tuesday, January 11 | 7:00AM - 8:00AM
Breakfast
Room: Madison/Gallatin


Tuesday, January 11 | 8:00AM - 11:00AM
Immunmodulation of Inflammatory Bowel Disease
Room: Jefferson

Speaker 1 of 5
Evan M. Beckman, Novartis Institutes for BioMedical Research, USA
Blocking Alpha 4 Integrin in Crohn's Disease

Tuesday, January 11 | 8:00AM - 11:00AM
Immunmodulation of Inflammatory Bowel Disease
Room: Jefferson

Speaker 2 of 5
Sander J. Van Deventer, Academic Medical Center, Netherlands
Inhibition of MAP Kinase for Treatment of IBD


Tuesday, January 11 | 8:00AM - 11:00AM
Immunmodulation of Inflammatory Bowel Disease
Room: Jefferson

Speaker 3 of 5
* Richard S. Blumberg, Brigham and Women's Hospital, USA
Blocking PPARgamma and IBD


Tuesday, January 11 | 8:00AM - 11:00AM
Immunmodulation of Inflammatory Bowel Disease
Room: Jefferson

Speaker 4 of 5
Warren Strober, National Institutes of Health, USA
Anti-IL-12 is an Effective Approach to the Treatment of the Th1-Mediated Inflammation in Crohn’s Disease

Tuesday, January 11 | 8:00AM - 11:00AM
Immunmodulation of Inflammatory Bowel Disease
Room: Jefferson

Speaker 5 of 5
Claire L. Langrish, Takeda San Francisco, USA
Short Talk: Differential Contributions of IL-12 and IL-23 to Autoimmune Inflammation

Tuesday, January 11 | 9:20AM - 9:40AM
Coffee Break
Room: Lower Atrium


Tuesday, January 11 | 3:30PM - 5:00PM
Workshop 2: Regulatory T Cells
Room: Jefferson

Speaker 1 of 9
* Randolph J. Noelle, Dartmouth College, USA

Tuesday, January 11 | 3:30PM - 5:00PM
Workshop 2: Regulatory T Cells
Room: Jefferson

Speaker 2 of 9
* Sander J. Van Deventer, Academic Medical Center, Netherlands

Tuesday, January 11 | 3:30PM - 5:00PM
Workshop 2: Regulatory T Cells
Room: Jefferson

Speaker 3 of 9
Brian T. Fife, University of Minnesota, USA
Antigen-Specific Tolerance as a Treatment for Autoimmune Diabetes in NOD Mice

Tuesday, January 11 | 3:30PM - 5:00PM
Workshop 2: Regulatory T Cells
Room: Jefferson

Speaker 4 of 9
Shuiping Jiang, King's College London, UK
Selection and Expansion of Antigen-Specific CD4+CD25+ Regulatory T Cells: Potential Reagents for Adoptive Cell Therapy

Tuesday, January 11 | 3:30PM - 5:00PM
Workshop 2: Regulatory T Cells
Room: Jefferson

Speaker 5 of 9
Benedikt Fritzsching, German Cancer Research Center, Germany
Sensitivity of Regulatory T Cells to Apoptosis and its Translation to Multiple Sclerosis

Tuesday, January 11 | 3:30PM - 5:00PM
Workshop 2: Regulatory T Cells
Room: Jefferson

Speaker 6 of 9
David A. Horwitz, University of Southern California, USA
Infectious Tolerance in vivo: The Transfer of Antigen-Specific Regulatory T Cells Generated ex-vivo Induces Recipient CD4+CD25+ Cells with Similar Specific Suppressive Activity

Tuesday, January 11 | 3:30PM - 5:00PM
Workshop 2: Regulatory T Cells
Room: Jefferson

Speaker 7 of 9
Karin Loser, University of Muenster, Germany
Treatment of Murine Allergic Contact Hypersensitivity and Systemic Autoimmunity with in vitro Generated Regulatory T Cells

Tuesday, January 11 | 3:30PM - 5:00PM
Workshop 2: Regulatory T Cells
Room: Jefferson

Speaker 8 of 9
Xavier Valencia, Boston Pharmaceuticals, USA
CD4+CD25+ T Regulatory Cell Function in Rheumatoid Arthritis

Tuesday, January 11 | 3:30PM - 5:00PM
Workshop 2: Regulatory T Cells
Room: Jefferson

Speaker 9 of 9
Kristin V. Tarbell, Amgen, USA
Islet-Specific CD4+CD25+ Regulatory T Cells can be Expanded from a Polyclonal Repertoire by Using Dendritic Cells

Tuesday, January 11 | 5:00PM - 5:30PM
Coffee & Snacks Available
Room: Lower Atrium


Tuesday, January 11 | 5:00PM - 7:15PM
Modulating the Regulatory Response
Room: Jefferson

Speaker 1 of 4
Ethan M. Shevach, NIAID, National Institutes of Health, USA
Activation and Modulation of T Regulatory Function in vivo

Tuesday, January 11 | 5:00PM - 7:15PM
Modulating the Regulatory Response
Room: Jefferson

Speaker 2 of 4
* Lucienne Chatenoud, INSERM U1151, Hôpital Necker-Enfants Malades, France
Regulation in Autoimmunity

Tuesday, January 11 | 5:00PM - 7:15PM
Modulating the Regulatory Response
Room: Jefferson

Speaker 3 of 4
David A. Hafler, Yale University School of Medicine, USA
Regulatory T Cells in MS


Tuesday, January 11 | 5:00PM - 7:15PM
Modulating the Regulatory Response
Room: Jefferson

Speaker 4 of 4
Joan Goverman, University of Washington, USA
Regulating the T Cell Response To Myelin Basic Protein

Tuesday, January 11 | 7:15PM - 8:15PM
Social Hour
Room: Madison/Gallatin


Wednesday, January 12 | 7:00AM - 8:00AM
Breakfast
Room: Madison/Gallatin


Wednesday, January 12 | 8:00AM - 11:00AM
Therapeutic Intervention in Lupus and Rheumatoid Arthritis
Room: Jefferson

Speaker 1 of 5
Robert H. Carter, NIAMS, National Institutes of Health, USA
Understanding B Cell Activation

Wednesday, January 12 | 8:00AM - 11:00AM
Therapeutic Intervention in Lupus and Rheumatoid Arthritis
Room: Jefferson

Speaker 2 of 5
* Betty Diamond, Feinstein Institute for Medical Research, USA
Regulating Autoreactive B Cells

Wednesday, January 12 | 8:00AM - 11:00AM
Therapeutic Intervention in Lupus and Rheumatoid Arthritis
Room: Jefferson

Speaker 3 of 5
Anne Davidson, Feinstein Institute for Medical Research, USA
Costimulatory Blockade in Murine SLE

Wednesday, January 12 | 8:00AM - 11:00AM
Therapeutic Intervention in Lupus and Rheumatoid Arthritis
Room: Jefferson

Speaker 4 of 5
Cornelia M. Weyand, Stanford University, USA
T Cells in Rheumatoid Arthritis

Wednesday, January 12 | 8:00AM - 11:00AM
Therapeutic Intervention in Lupus and Rheumatoid Arthritis
Room: Jefferson

Speaker 5 of 5
Mieke Boots, NV Organon, Netherlands
Short Talk: Functional Characterization of a Rheumatoid Arthritis-Associated Epitope Using T Cell Hybridomas Recognizing the HLA-DR4(B1*0401)/HC gp-39 (263-275) Complex

Wednesday, January 12 | 9:20AM - 9:40AM
Coffee Break
Room: Lower Atrium


Wednesday, January 12 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Lower Atrium


Wednesday, January 12 | 5:00PM - 7:00PM
Gene Therapy in Autoimmunity
Room: Jefferson

Speaker 1 of 2
* Alan Tyndall, University Hospital Basel, Switzerland
Stem Cells Treatment of Severe Autoimmune Disease

Wednesday, January 12 | 5:00PM - 7:00PM
Gene Therapy in Autoimmunity
Room: Jefferson

Speaker 2 of 2
Carrie D. Beal, Cleveland Clinic Foundation, USA
Short Talk: Amelioration of Established EAE by an MHC Anchor Substituted Variant of PLP 139-151

Wednesday, January 12 | 7:00PM - 8:00PM
Social Hour
Room: Madison/Gallatin


Wednesday, January 12 | 8:00PM - 11:00PM
Entertainment
Room: Madison/Gallatin


Wednesday, January 12 | 8:00PM - 11:00PM
Cash Bar
Room: Madison/Gallatin


Thursday, January 13 | 10:26AM - 10:26AM
Departure


*Session Chair.