Web Desc
Meeting the Challenges of Drug Discovery
Organizer(s): Stephen W. Fesik and Michael D. Varney
Date: January 15 - 20, 2005
Location: Fairmont Hotel Vancouver, Vancouver, BC, Canada
Sponsored by Iconix Pharmaceuticals, Inc. and ICOS Corporation
For important information on the coronavirus, please click here
Summary of Meeting:
The drug discovery process is difficult, challenging, costly, and often leads to failure. Nevertheless, it is critical that we continue to discover new drugs to meet the many unmet medical needs. To reduce the costs and improve the success of drug discovery and development, new technologies and strategies have been developed. To aid in the target identification and validation steps of the drug discovery process, RNAi technology for gene knockdown is playing an important role along with large-scale gene knockouts in animals. Novel screening approaches, high-throughput synthesis, iterative structure-based design, and in vitro toxicity assays are aiding lead identification and optimization. In addition, approaches are being developed for identifying and utilizing biomarkers in clinical trials to improve the success of drug approval. Advances have also been made in the discovery of biomolecules for the treatment of disease. In this Keystone Symposium, approaches for streamlining and improving drug discovery and development will be discussed that include enabling technologies to aid in target identification/validation and lead identification/optimization, strategies for discovering and applying DNA, RNA, and protein biomarkers in pre-clinical studies and clinical trials, and the use of biologicals to treat disease. In addition, success stories on new drug candidates will be presented.
Discounted Abstract Deadline: September 20 2004
Discounted Registration Deadline: November 15 2004
We gratefully acknowledge additional support for this conference from:
Cell Signaling Technology, Inc.Iconix Biosciences, Inc.ICOS CorporationNovartis Institutes for BioMedical Research
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Abbott Laboratories

Agouron Pharmaceuticals, Inc.

Alnylam Pharmaceuticals, Inc.

AVEO Pharmaceuticals, Inc.

Bristol-Myers Squibb Company

CeeTox Inc.

Chiron Corporation

Galapagos NV

Genentech, Inc.

Iconix Biosciences, Inc.

ICOS Corporation

Isis Pharmaceuticals, Inc.

Kalypsys, Inc.

Lexicon Pharmaceuticals Inc.

Merck Research Laboratories

Novartis Institutes for BioMedical Research

Odyssey Thera

Ozgene Pty Ltd

SGX Pharmaceuticals

Syrrx, Inc.

Vertex Pharmaceuticals Incorporated
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Saturday, January 15 | 3:00PM - 7:30PM
Registration
Room: BC Foyer


Saturday, January 15 | 6:30PM - 7:30PM
Refreshments
Room: BC Foyer


Saturday, January 15 | 7:30PM - 8:30PM
Keynote Address
Room: British

Speaker 1 of 1
Leslie J. Browne, Senesco Technologies, Inc., USA
The Future of Drug Discovery - Where Do We Go From Here?

Sunday, January 16 | 7:00AM - 8:00AM
Breakfast
Room: Columbia


Sunday, January 16 | 8:00AM - 11:00AM
Selecting the Right Targets
Room: British

Speaker 1 of 4
* Brian Zambrowicz, Regeneron, USA
Genetic Modeling of Chemical Antagonists: Genome-Scale Discovery of Drug Targets by in vivo Functional Analysis

Sunday, January 16 | 8:00AM - 11:00AM
Selecting the Right Targets
Room: British

Speaker 2 of 4
Stewart Noble, Kalypsys, Inc., USA
Driving Target Selection by Compound Profiling

Sunday, January 16 | 8:00AM - 11:00AM
Selecting the Right Targets
Room: British

Speaker 3 of 4
Frank Koentgen, Ozgene Pty Ltd, Australia
Use of RNAi for Gene Knockdown in Mice

Sunday, January 16 | 8:00AM - 11:00AM
Selecting the Right Targets
Room: British

Speaker 4 of 4
William L. Wishart, Novartis Institutes for BioMedical Research, Switzerland
RNAi/Antisense Based Drug Target Validation In Vivo.

Sunday, January 16 | 9:20AM - 9:40AM
Coffee Break
Room: BC Foyer


Sunday, January 16 | 11:00AM - 1:00PM
Poster Setup
Room: Columbia


Sunday, January 16 | 1:00PM - 10:00PM
Poster Viewing
Room: Columbia


Sunday, January 16 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: BC Foyer


Sunday, January 16 | 5:00PM - 7:00PM
Speeding up the Drug Discovery Process
Room: British

Speaker 1 of 3
* Stephen K. Burley, Rutgers University, USA
Structure-Guided Drug Discovery Using Fragment-Based Lead Identification/Lead Optimization

Sunday, January 16 | 5:00PM - 7:00PM
Speeding up the Drug Discovery Process
Room: British

Speaker 2 of 3
David J. Burns, Abbott Laboratories, USA
HTS for Expediting Drug Discovery

Sunday, January 16 | 5:00PM - 7:00PM
Speeding up the Drug Discovery Process
Room: British

Speaker 3 of 3
Gerhard Klebe, Philipps University Marburg, Germany
Virtual Ligand Screening: Successes and Limitations

Sunday, January 16 | 7:00PM - 8:00PM
Social Hour
Room: Columbia


Sunday, January 16 | 7:30PM - 10:00PM
Poster Session 1
Room: Columbia


Monday, January 17 | 7:00AM - 8:00AM
Breakfast
Room: Columbia


Monday, January 17 | 8:00AM - 11:00AM
Early Detection of Toxicity
Room: British

Speaker 1 of 4
* Stephen K. Durham, Bristol-Myers Squibb Company, USA
Addressing Drug Safety Liabilities Early in the Drug Discovery Process

Monday, January 17 | 8:00AM - 11:00AM
Early Detection of Toxicity
Room: British

Speaker 2 of 4
Kyle L. Kolaja, Celgene, USA
The Use of a Chemogenomic Reference Database to Optimize Drug Candidate Selection

Monday, January 17 | 8:00AM - 11:00AM
Early Detection of Toxicity
Room: British

Speaker 3 of 4
James M. McKim, Jr., CeeTox, USA
Incorporating in vitro Toxicity Data into Early Drug Discovery

Monday, January 17 | 8:00AM - 11:00AM
Early Detection of Toxicity
Room: British

Speaker 4 of 4
Dale E. Johnson, Emiliem, Inc., USA
Computational Approaches for the Prediction of Drug-Induced Toxicity

Monday, January 17 | 9:20AM - 9:40AM
Coffee Break
Room: BC Foyer


Monday, January 17 | 11:00AM - 1:00PM
Poster Setup
Room: Columbia


Monday, January 17 | 1:00PM - 10:00PM
Poster Viewing
Room: Columbia


Monday, January 17 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: BC Foyer


Monday, January 17 | 5:00PM - 7:00PM
More Predictive Animal Models
Room: British

Speaker 1 of 3
* Chand Khanna, National Cancer Institute, National Institutes of Health, USA
A Novel and Integrated Approach towards Cancer Drug Development: Evaluation of Early Clinical Agents in Companion Animals with Cancer

Monday, January 17 | 5:00PM - 7:00PM
More Predictive Animal Models
Room: British

Speaker 2 of 3
Irene Tracey, University of Oxford, UK
Functional Magnetic Resonance Imaging of Pain Processing in Humans - Beyond Animal Models

Monday, January 17 | 5:00PM - 7:00PM
More Predictive Animal Models
Room: British

Speaker 3 of 3
Murray O. Robinson, Molquant, Inc., USA
Inducible Tumor Models for Target Identification and Drug Discovery

Monday, January 17 | 7:00PM - 8:00PM
Social Hour
Room: Columbia


Monday, January 17 | 7:30PM - 10:00PM
Poster Session 2
Room: Columbia


Tuesday, January 18 | 7:00AM - 8:00AM
Breakfast
Room: Columbia


Tuesday, January 18 | 8:00AM - 11:00AM
Useful Tools for Decision Making in the Clinic
Room: British

Speaker 1 of 3
* Todd R. Golub, Broad Institute, USA
Genomic Information and Cancer

Tuesday, January 18 | 8:00AM - 11:00AM
Useful Tools for Decision Making in the Clinic
Room: British

Speaker 2 of 3
Roger G. Ulrich, RUC Pharmaceutical Development Specialists, USA
Improving Drug Development through Molecular Profiling

Tuesday, January 18 | 8:00AM - 11:00AM
Useful Tools for Decision Making in the Clinic
Room: British

Speaker 3 of 3
Samir Hanash, Fred Hutchinson Cancer Research Center, USA
Contributions of Proteomics to the Drug Discovery Process

Tuesday, January 18 | 9:20AM - 9:40AM
Coffee Break
Room: BC Foyer


Tuesday, January 18 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: BC Foyer


Tuesday, January 18 | 5:00PM - 7:00PM
Biologics
Room: British

Speaker 1 of 3
* C. Frank Bennett, Ionis Pharmaceuticals, Inc., USA
Progress in Antisense Oligonucleotide Based Therapeutics

Tuesday, January 18 | 5:00PM - 7:00PM
Biologics
Room: British

Speaker 2 of 3
Napoleone Ferrara, University of California, San Diego, USA
Antibodies Against VEGF

Tuesday, January 18 | 5:00PM - 7:00PM
Biologics
Room: British

Speaker 3 of 3
John M. Maraganore, Alnylam Pharmaceuticals Inc., USA
Turning siRNA's into Drugs

Tuesday, January 18 | 7:00PM - 8:00PM
Social Hour
Room: Columbia


Wednesday, January 19 | 7:00AM - 8:00AM
Breakfast
Room: Columbia


Wednesday, January 19 | 8:00AM - 11:00AM
New Drug Candidates
Room: British

Speaker 1 of 4
* Stephen W. Kaldor, Quanticel Pharmaceuticals, USA
DPP IV Antagonists


Wednesday, January 19 | 8:00AM - 11:00AM
New Drug Candidates
Room: British

Speaker 2 of 4
Daria J. Hazuda, Merck Research Laboratories, USA
Pyrophosphate Mimetics: A Mechanism Based Approach to Antiviral Drug Discovery

Wednesday, January 19 | 8:00AM - 11:00AM
New Drug Candidates
Room: British

Speaker 3 of 4
John A. Thomson, Vertex Pharmaceuticals Incorporated, USA
Mechanism-Based Design of Synergistic Therapeutics for Hepatitis C

Wednesday, January 19 | 8:00AM - 11:00AM
New Drug Candidates
Room: British

Speaker 4 of 4
Joel Hayflick, USA
PI3 Kinase delta Inhibitors for the Treatment of Cancer and Autoimmune Diseases

Wednesday, January 19 | 9:20AM - 9:40AM
Coffee Break
Room: BC Foyer


Wednesday, January 19 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: BC Foyer


Wednesday, January 19 | 5:00PM - 7:00PM
Hot Breaking Stories
Room: British

Speaker 1 of 4
* Steven Elmore, Abbott Laboratories, USA
Bcl-2 Family Inhibitors for the Treatment of Cancer

Wednesday, January 19 | 5:00PM - 7:00PM
Hot Breaking Stories
Room: British

Speaker 2 of 4
Prasanna G. Alluri, University of Minnesota School of Medicine, USA
Short Talk: A Chemical Genetic Approach to Regulation of Gene Expression

Wednesday, January 19 | 5:00PM - 7:00PM
Hot Breaking Stories
Room: British

Speaker 3 of 4
Marcel Hoffmann, Crystallics, Netherlands
Short Talk: Drug Targets with Functional Diseas Relevance Discovered with Arrayed Adenoviral siRNA Libraries

Wednesday, January 19 | 5:00PM - 7:00PM
Hot Breaking Stories
Room: British

Speaker 4 of 4
John Keirn Westwick, Odyssey Thera, Inc., USA
Short Talk: Defining Drug Mechanism of Action within Human Cellular Networks

Wednesday, January 19 | 7:00PM - 8:00PM
Social Hour
Room: Columbia


Wednesday, January 19 | 8:00PM - 11:00PM
Entertainment
Room: Columbia


Wednesday, January 19 | 8:00PM - 11:00PM
Cash Bar
Room: Columbia


Thursday, January 20 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.